Log in

Relevant bibliographies by topics / Pulsed Field Ablation / Journal articles

To see the other types of publications on this topic, follow the link: Pulsed Field Ablation.

Journal articles on the topic 'Pulsed Field Ablation'

Author: Grafiati

Published: 25 January 2025

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Pulsed Field Ablation.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Guttipatti, Pavithran, Najla Saadallah, and Elaine Y. Wan. "Pulsed Field Ablation for the Treatment of Atrial Fibrillation: A Review and a Look into its Future." Heart Surgery Forum 27, no. 2 (2024): E169—E179. http://dx.doi.org/10.59958/hsf.7141.

Full text

Abstract:

Pulsed field ablation (PFA) is a novel technology to treat atrial fibrillation (AF) utilizing electric fields to induce nonthermal irreversible electroporation of electrically active cardiac tissue to induce cardiac cell death. PFA offers improved safety benefits compared to traditional radiofrequency ablation (RFA) and cryoablation by specifically ablating only cardiac tissue. However, there are avenues for further optimization including neurological risk associated with microbubble formation and left atrial function post ablation. Various PFA devices with different electric pulse waveforms h

APA, Harvard, Vancouver, ISO, and other styles

2

Reinsch, Nico, Anna Füting, Dennis Höwel, and Kars Neven. "„Pulsed field ablation“." Herzschrittmachertherapie + Elektrophysiologie 33, no. 1 (2022): 12–18. http://dx.doi.org/10.1007/s00399-021-00833-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Bourier, Felix. "Pulsed-Field-Ablation." CardioVasc 23, no. 2 (2023): 30–32. http://dx.doi.org/10.1007/s15027-023-2967-z.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Ferencz, Arnold Béla, Zoltán Salló, László Gellér, and Nándor Szegedi. "Pulsed field ablation – Elektroporáció." Cardiologia Hungarica 54, no. 2 (2024): 104–9. http://dx.doi.org/10.26430/chungarica.2024.54.2.104.

Full text

Abstract:

A pitvarfibrilláció (AF) a leggyakoribb szívritmuszavar, amelynek kezelésében elsődleges szerepet a tüdővéna-izoláció (pulmonálisvéna-izoláció, PVI) játszik. A PVI ma már biztonságos és hatékony beavatkozásként tartható számon. Rendszerint eddig a PVI-t a termikus energia segítségével végeztük (krio-, illetve rádiófrekvenciás abláció). A pulsed field abláció (PFA), azaz elektroporáció egy új, nem termikus energiát használó abláció, amely során kialakuló elektromos mező a szívizomsejtek szelektív károsításához vezet. A preklinikai vizsgálatok kitérnek a PFA-lézió létrehozásának biztonságosságár

APA, Harvard, Vancouver, ISO, and other styles

5

Zhao, Zhihong, Yonggang Chen, Bin Wu, et al. "Pulsed-Field Ablation Using a Novel Ablation-Mapping Integrated System for Pulmonary Vein Isolation—A Preliminary Animal Study." Journal of Cardiovascular Development and Disease 9, no. 12 (2022): 425. http://dx.doi.org/10.3390/jcdd9120425.

Full text

Abstract:

Objective: The purpose of this study is to evaluate the preliminary safety and effect of a pulsed electric field (PEF) ablation system. Methods: The pulmonary veins (PVs) and superior vena cava (SVC) were isolated with the pulsed field ablation (PFA) system, which included a PEF generator and an electrode. The effects of PFA were investigated in six porcines using a novel circular catheter with combined functions (mapping/ablation) designed to work with a cardiac mapping system. The PEF generator delivered a train of biphasic pulsed electric pulses with a high amplitude (800–2000 V) and short

APA, Harvard, Vancouver, ISO, and other styles

6

Fried, Daniel, Toshimoto Kushida, Gene P. Reck, and Erhard W. Rothe. "YO A2II1/2,3/2 Vibrational State Distributions Measured after the Excimer Laser Ablation of Y2O3 Using a Laser-Initiated Pulsed Discharge as a Probe." Applied Spectroscopy 48, no. 2 (1994): 248–51. http://dx.doi.org/10.1366/0003702944028380.

Full text

Abstract:

The vibrational populations of the YO A2II- X2Σ system of YO were measured in the plasmas generated after the excimer laser ablation of Y2O3 in oxygen when both continuous and pulsed electric fields were applied. When an electric field is applied antiparallel to the direction of propagation of the ejected electrons, two luminous plumes appear, separated by several microseconds. The measured vibrational populations of the YO A2II- X2Σ system are different for each plume. The YO A2II populations were nonthermal in the first plume, representing emission from chemiluminescent reactive collisions i

APA, Harvard, Vancouver, ISO, and other styles

7

Kautzner, Josef, Jana Haskova, Jakub Cvek, Marek Adamira, and Petr Peichl. "Hypertrophic obstructive cardiomyopathy with recurrent ventricular tachycardias: from catheter ablation and stereotactic radiotherapy to heart transplant-a case report." European heart journal. Case reports 8, no. 8 (2024): art. no. ytae379. https://doi.org/10.1093/ehjcr/ytae379.

Full text

Abstract:

Background Management of hypertrophic obstructive cardiomyopathy (HOCM) is often challenging, depending on clinical manifestation. This case report illustrates the complex treatment of HOCM with associated recurrent ventricular arrhythmias.Case summary A 54-year-old female with HOCM diagnosed in 2012 underwent a failed attempt for alcohol septal ablation, implantation of an implantable cardioverter-defibrillator, and repeated radiofrequency ablations (including ablation of the septal bulge to reduce LV obstruction). For ventricular tachycardia (VT) recurrences, she had stereotactic arrhythmia

APA, Harvard, Vancouver, ISO, and other styles

8

Defaye, Pascal, and Sandrine Venier. "Hemolysis During Pulsed-Field Ablation." JACC: Clinical Electrophysiology 10, no. 7 (2024): 1672–74. http://dx.doi.org/10.1016/j.jacep.2024.06.007.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Stephen J, Beebe. "Considerations for Exploring Nanosecond Pulsed Electric Fields (nsPEFs) for Treatments of Cancer, Benign Skin Diseases, Atrial Fibrillation, and for New Mechanistic Understandings." Records of Cell & Bioscience 1, no. 1 (2024): 001–7. http://dx.doi.org/10.17352/rcb.000001.

Full text

Abstract:

Pulsed power includes acquiring electrical energy, compressing it, and releasing it in instantaneous bursts that are low in energy but very high in power. When the pulse duration is near the plasma membrane charging time constant, which is the time during which the cell interior is exposed to the applied pulsed electric field, it affects intracellular structures and functions. The technology is called nanosecond Pulsed Electric Fields (nsPEFs), nanosecond electric pulses (nsEP), or Nanopulse Stimulation (NPSTM) according to Pulse Biosciences, Inc., a company taking the technology to the market

APA, Harvard, Vancouver, ISO, and other styles

10

Qiu, Jie, Meiyan Dai, Yang Bai, and Guangzhi Chen. "Potential Application of Pulsed Field Ablation in Ventricular Arrhythmias." Medicina 59, no. 4 (2023): 723. http://dx.doi.org/10.3390/medicina59040723.

Full text

Abstract:

Pulsed field ablation (PFA) is a new ablative method for the therapy of arrhythmia. Recent preclinical and clinical studies have already demonstrated the feasibility and safety of PFA for the treatment of atrial fibrillation (AF). However, the application of PFA may not be limited to the above fields. There are some data on the application of PFA on ventricular arrhythmias (VAs), such as ventricular fibrillation (VF) and ventricular tachycardia (VT). Further, a case report about PFA has been published recently, in which PFA was successfully applied to the ablation of premature ventricular cont

APA, Harvard, Vancouver, ISO, and other styles

11

O’Brien, Barry, John Reilly, Ken Coffey, et al. "Epicardial Pulsed Field Ablation of Ganglionated Plexi: Computational and Pre-Clinical Evaluation of a Bipolar Sub-Xiphoid Catheter for the Treatment of Atrial Fibrillation." Bioengineering 11, no. 1 (2023): 18. http://dx.doi.org/10.3390/bioengineering11010018.

Full text

Abstract:

Epicardial pulsed field ablation (PFA) of ganglionated plexi (GPs) is being explored as a potential treatment for atrial fibrillation. Initial work using open-chest access with a monopolar ablation device has been completed. This study describes the early development work for a device that can be used with subxiphoid access and deliver bipolar ablation pulses. Electric field computational models have been used for the initial guidance on pulse parameters. An in vivo assessment of these ablation parameters has been performed in an open-chest canine study, while subxiphoid access and navigation

APA, Harvard, Vancouver, ISO, and other styles

12

Wojtaszczyk, Adam, Paweł Ptaszyński, and Krzysztof Kaczmarek. "Pulsed field ablation – new perspective in atrial fibrillation therapy." In a good rythm 1, no. 58 (2021): 4–7. http://dx.doi.org/10.5604/01.3001.0015.0102.

Full text

Abstract:

Atrial fibrillation (AF) is one of the most important problems in cardiology. Thermal ablation therapies are “gold standard” to treat symptomatic patients. Despite the improvements, both success rate and safety are limited by their thermal nature. Pulsed filed ablation is a new non-thermal ablation method. It is based on the phenomenon of unrecoverable permeabilization of cell membranes caused by pulses of high voltage (irreversible electroporation). Several preclinical studies suggest its safety. Clinical trials published so far have showed high efficacy. Further studies especially with longe

APA, Harvard, Vancouver, ISO, and other styles

13

Ruwald, Martin H., Arne Johannessen, Morten Lock Hansen, Rene Worck, and Jim Hansen. "Pulsed field ablation of the cavotricuspid isthmus using a multispline-electrode pulsed field ablation catheter." HeartRhythm Case Reports 8, no. 3 (2022): 147–50. http://dx.doi.org/10.1016/j.hrcr.2021.12.009.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Ezzeddine, Fatima M., Samuel J. Asirvatham, and Duy T. Nguyen. "Pulsed Field Ablation: A Comprehensive Update." Journal of Clinical Medicine 13, no. 17 (2024): 5191. http://dx.doi.org/10.3390/jcm13175191.

Full text

Abstract:

One of the recent advancements in the field of cardiac electrophysiology is pulsed field ablation (PFA). PFA is a novel energy modality that does not rely on thermal processes to achieve ablation which, in turn, results in limited collateral damage to surrounding structures. In this review, we discuss the mechanisms, safety, efficacy, and clinical applications of PFA for the management of atrial and ventricular arrhythmias. We also summarize the published pre-clinical and clinical studies regarding this new technology.

APA, Harvard, Vancouver, ISO, and other styles

15

Mathuria, Nilesh. "Pulsed-Field Ablation for Atrial Fibrillation." JACC: Clinical Electrophysiology 7, no. 5 (2021): 628–29. http://dx.doi.org/10.1016/j.jacep.2021.03.007.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Okumura, Yasuo, and Naoto Otsuka. "Pulsed Field Ablation for Atrial Fibrillation." Journal of Nihon University Medical Association 84, no. 3 (2025): 125–26. https://doi.org/10.4264/numa.84.3_125.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Scuderi, Maria, Janja Dermol-Černe, Tina Batista Napotnik, et al. "Characterization of Experimentally Observed Complex Interplay between Pulse Duration, Electrical Field Strength, and Cell Orientation on Electroporation Outcome Using a Time-Dependent Nonlinear Numerical Model." Biomolecules 13, no. 5 (2023): 727. http://dx.doi.org/10.3390/biom13050727.

Full text

Abstract:

Electroporation is a biophysical phenomenon involving an increase in cell membrane permeability to molecules after a high-pulsed electric field is applied to the tissue. Currently, electroporation is being developed for non-thermal ablation of cardiac tissue to treat arrhythmias. Cardiomyocytes have been shown to be more affected by electroporation when oriented with their long axis parallel to the applied electric field. However, recent studies demonstrate that the preferentially affected orientation depends on the pulse parameters. To gain better insight into the influence of cell orientatio

APA, Harvard, Vancouver, ISO, and other styles

18

Yavin, Hagai, Mark Prasad, Jonathan Gordon, Tolga Aksu, and Henry D. Huang. "Contemporary Trends in Pulsed Field Ablation for Cardiac Arrhythmias." Journal of Cardiovascular Development and Disease 12, no. 1 (2024): 10. https://doi.org/10.3390/jcdd12010010.

Full text

Abstract:

Pulsed field ablation (PFA) is a catheter-based procedure that utilizes short high voltage and short-duration electrical field pulses to induce tissue injury. The last decade has yielded significant scientific progress and quickened interest in PFA as an energy modality leading to the emergence of the clinical use of PFA technologies for the treatment of atrial fibrillation. It is generally agreed that more research is needed to improve our biophysical understanding of PFA for clinical cardiac applications as well as its potential as a potential alternative energy source to thermal ablation mo

APA, Harvard, Vancouver, ISO, and other styles

19

THAREJA, RAJ K., and A. K. SHARMA. "Reactive pulsed laser ablation: Plasma studies." Laser and Particle Beams 24, no. 2 (2006): 311–20. http://dx.doi.org/10.1017/s0263034606060484.

Full text

Abstract:

We report on the pulsed laser ablation of aluminum (Al) plasma in presence of ambient nitrogen to understand the formation of aluminum nitride (AlN). Formation of carbon nitride (CN) and titanium oxide (TiO) by pulsed laser-ablation of graphite and titanium targets in presence of ambient nitrogen and oxygen is also compared. We discuss the dynamics of plasma expansion based on existing models, shock and drag models, and the plasma gas interface distortion, Rayleigh-Taylor instability at various ambient pressures of nitrogen. Since Rayleigh-Taylor instability may give rise to self-generated mag

APA, Harvard, Vancouver, ISO, and other styles

20

Narkar, Akshay, Abouzar Kaboudian, Yasaman Ardershirpour, Maura Casciola, Tromondae K. Feaster, and Ksenia Blinova. "In Vitro Assay Development to Study Pulse Field Ablation Outcome Using Solanum Tuberosum." International Journal of Molecular Sciences 25, no. 16 (2024): 8967. http://dx.doi.org/10.3390/ijms25168967.

Full text

Abstract:

Exposing cells to intense and brief electric field pulses can modulate cell permeability, a phenomenon termed electroporation. When applied in medical treatments of diseases like cancer and cardiac arrhythmias, depending on level of cellular destruction, it is also referred to as irreversible electroporation (IRE) or Pulsed Field Ablation (PFA). For ablation device testing, several pulse parameters need to be characterized in a comprehensive manner to assess lesion boundary and efficacy. Overly aggressive voltages and application numbers increase animal burden. The potato tuber is a widely use

APA, Harvard, Vancouver, ISO, and other styles

21

Esser, Axel T., Kyle C. Smith, T. R. Gowrishankar, and James C. Weaver. "Towards Solid Tumor Treatment by Nanosecond Pulsed Electric Fields." Technology in Cancer Research & Treatment 8, no. 4 (2009): 289–306. http://dx.doi.org/10.1177/153303460900800406.

Full text

Abstract:

Local and drug-free solid tumor ablation by large nanosecond pulsed electric fields leads to supra-electroporation of all cellular membranes and has been observed to trigger nonthermal cell death by apoptosis. To establish pore-based effects as the underlying mechanism inducing apoptosis, we use a multicellular system model (spatial scale 100 μm) that has irregularly shaped liver cells and a multiscale liver tissue model (spatial scale 200 mm). Pore histograms for the multicellular model demonstrate the presence of only nanometer-sized pores due to nanosecond electric field pulses. The number

APA, Harvard, Vancouver, ISO, and other styles

22

Xiong, Chang-Wei, Ching-Yen Ho, and Dong-Kai Qiao. "Analysis of Direct Optical Ablation and Sequent Thermal Ablation for the Ultrashort Pulsed Laser Photo-Thermal Micromachining." Coatings 10, no. 12 (2020): 1151. http://dx.doi.org/10.3390/coatings10121151.

Full text

Abstract:

An ultra-fast pulsed laser for materials processing can obtain submicrometer- to nanometer-sized parts or patterns (precision or accuracy) because the heat cannot diffuse in time for an ultra-fast pulsed duration, and this causes a threshold of ablation in multi-photoabsorption. The optical and thermal effects significantly affect the processing quality of an ultrashort pulsed laser for materials. This study utilizes a Laplace transform method to display the optical and thermal effects on the temperature field and the ablated depth of an ultrashort pulsed laser processing of materials. The res

APA, Harvard, Vancouver, ISO, and other styles

23

Baykaner, Tina, Muhammad Fazal, and Atul Verma. "Taking the “pulse” of pulsed‐field ablation: Real‐world experience." Journal of Cardiovascular Electrophysiology 33, no. 3 (2022): 357–59. http://dx.doi.org/10.1111/jce.15348.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Gudvangen, Emily, Uma Mangalanathan, Iurii Semenov, et al. "Pulsed Electric Field Ablation of Esophageal Malignancies and Mitigating Damage to Smooth Muscle: An In Vitro Study." International Journal of Molecular Sciences 24, no. 3 (2023): 2854. http://dx.doi.org/10.3390/ijms24032854.

Full text

Abstract:

Cancer ablation therapies aim to be efficient while minimizing damage to healthy tissues. Nanosecond pulsed electric field (nsPEF) is a promising ablation modality because of its selectivity against certain cell types and reduced neuromuscular effects. We compared cell killing efficiency by PEF (100 pulses, 200 ns–10 µs duration, 10 Hz) in a panel of human esophageal cells (normal and pre-malignant epithelial and smooth muscle). Normal epithelial cells were less sensitive than the pre-malignant ones to unipolar PEF (15–20% higher LD50, p < 0.05). Smooth muscle cells (SMC) oriented randomly

APA, Harvard, Vancouver, ISO, and other styles

25

Pakhomova, Olga N., Eleni Zivla, Giedre Silkuniene, Mantas Silkunas, and Andrei G. Pakhomov. "Potentiation of Gelonin Cytotoxicity by Pulsed Electric Fields." International Journal of Molecular Sciences 26, no. 2 (2025): 458. https://doi.org/10.3390/ijms26020458.

Full text

Abstract:

Gelonin is a ribosome-inactivating protein with extreme intracellular toxicity but poor permeation into cells. Targeted disruption of cell membranes to facilitate gelonin entry is explored for cancer and tissue ablation. We demonstrate a hundreds- to thousands-fold enhancement of gelonin cytotoxicity by pulsed electric fields in the T24, U-87, and CT26 cell lines. The effective gelonin concentration to kill 50% of cells (EC50) after electroporation ranged from <1 nM to about 100 nM. For intact cells, the EC50 was unattainable even at the highest gelonin concentration of 1000 nM, which reduc

APA, Harvard, Vancouver, ISO, and other styles

26

Weyand, Sebastian, Viola Adam, Paloma Biehler, et al. "Focal Pulsed Field Ablation for Atrial Arrhythmias: Efficacy and Safety under Deep Sedation." Journal of Clinical Medicine 13, no. 2 (2024): 576. http://dx.doi.org/10.3390/jcm13020576.

Full text

Abstract:

Focal pulsed field ablation (PFA) is a novel technique for treating cardiac arrhythmias. It has demonstrated positive results in initial studies and has a good safety profile. In recent studies, PFA was often utilized for first-time pulmonary vein isolation (PVI) and was performed under general anesthesia. In our study, we assessed the feasibility, safety, acute procedural efficacy, and efficiency of focal PFA under deep sedation in patients, 80% of whom had undergone at least one left atrial ablation previously. We treated 30 patients (71 ± 7, 46% male) using the CENTAURI system for various a

APA, Harvard, Vancouver, ISO, and other styles

27

Sullivan, Andrew P., Martin Aguilar, and Zachary Laksman. "Pulsed Field Ablation: A Review of Preclinical and Clinical Studies." Bioengineering 12, no. 4 (2025): 329. https://doi.org/10.3390/bioengineering12040329.

Full text

Abstract:

Pulsed field ablation (PFA) is an emerging technology that utilizes ultra-short high-voltage electric pulses to create nanopores in cell membranes, leading to cell death through irreversible electroporation (IRE). PFA is touted to be highly tissue-selective, which may mitigate the risk of collateral injury to vital adjacent structures. In the field of cardiac electrophysiology, initial studies have shown promising results for acute pulmonary vein isolation (PVI) and lesion durability, with overall freedom from recurrent atrial arrhythmia comparable to traditional thermal ablation modalities. W

APA, Harvard, Vancouver, ISO, and other styles

28

Yu, Fengyuan, and Min Tang. "Pulsed Field Ablation in the Treatment of Cardiac Arrhythmias: A State-of-the-art Review." International Journal of Heart Rhythm 9, no. 1 (2024): 12–18. http://dx.doi.org/10.4103/ijhr.ijhr_6_24.

Full text

Abstract:

Abstract Pulsed-field ablation (PFA), specifically irreversible electroporation, induces cell membrane damage through the formation of irreversible pores, leading to apoptosis and necrosis, with applications in tumor treatment and myocardium ablation since 2007. This review is on PFA in the treatment of cardiac arrhythmias, including the basic principles, clinical applications, and hot issues of PFA. Presently, the pulsed electric field has demonstrated its effectiveness and safety in the treatment of atrial fibrillation, which is not inferior to that of traditional thermal energy. Research an

APA, Harvard, Vancouver, ISO, and other styles

29

Reddy, Vivek Y., Srinivas R. Dukkipati, Petr Neuzil, et al. "Pulsed Field Ablation of Paroxysmal Atrial Fibrillation." JACC: Clinical Electrophysiology 7, no. 5 (2021): 614–27. http://dx.doi.org/10.1016/j.jacep.2021.02.014.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Lindemann, F., S. Nedios, T. Seewöster, and G. Hindricks. "Pulmonalvenenisolation bei Vorhofflimmern mittels „pulsed field ablation“." Herz 46, no. 4 (2021): 318–22. http://dx.doi.org/10.1007/s00059-021-05047-w.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Matthee, Ashton, Zahra Aghababaie, Linley A. Nisbet, et al. "Pulsed-field ablation: An alternative ablative method for gastric electrophysiological intervention." American Journal of Physiology-Gastrointestinal and Liver Physiology, July 16, 2024. http://dx.doi.org/10.1152/ajpgi.00124.2024.

Full text

Abstract:

Pulsed-field ablation (PFA) is an emerging ablative technology that has been used successfully to eliminate cardiac arrhythmias. As a non-thermal technique it has significant benefits over traditional radio-frequency ablation with improved target tissue specificity and reduced risk of adverse events during cardiac applications. We investigated whether PFA is safe for use in the stomach and whether it could modulate gastric slow waves. Female weaner pigs were fasted overnight before anesthesia was induced using tiletamine hydrochloride (50 mg mL-1) and zolazepam hydrochloride (50 mg mL-1) and m

APA, Harvard, Vancouver, ISO, and other styles

32

Bi, Shengyu, Fenglin Jia, Chang Lv, et al. "Preclinical Study of Biphasic Asymmetric Pulsed Field Ablation." Frontiers in Cardiovascular Medicine 9 (March 24, 2022). http://dx.doi.org/10.3389/fcvm.2022.859480.

Full text

Abstract:

Pulsed field ablation (PFA) is a novel method of pulmonary venous isolation in atrial fibrillation ablation and is featured by tissue-selective ablation. Isolation is achieved via the application of high-voltage microsecond pulses that create irreversible perforations in cell membranes (i.e., electroporation). We proposed a new biphasic asymmetric pulse mode and verified the lesion persistence and safety of this mode for pulmonary vein ostia ablation in preclinical studies. We found that biphasic asymmetric pulses can effectively reduce muscle contractions and drop ablation threshold. In the e

APA, Harvard, Vancouver, ISO, and other styles

33

Mercado Montoya, M., T. Gomez Bustamante, E. Kulstad, S. Mickelsen, and A. Gonzalez Suarez. "Analysis of thermal effects from pulsed field ablation." European Heart Journal 44, Supplement_2 (2023). http://dx.doi.org/10.1093/eurheartj/ehad655.381.

Full text

Abstract:

Abstract Background Pulsed field ablation (PFA) has been described as non-thermal, but abundant data exist in oncology applications [1-3], and growing data are emerging in cardiology [4], highlighting that thermal effects are in fact present with PFA. The particular parameters (such as voltage, pulse gap, pulse number) that most influence the development of thermal energy during PFA are less clear. Purpose We sought to evaluate the thermal effects arising from pulsed field ablation of myocardial and esophageal tissue over a range of typical peak voltage operating conditions. Methods Using a th

APA, Harvard, Vancouver, ISO, and other styles

34

Mercado Montoya, M., T. Gomez Bustamante, M. Jessen, E. Kulstad, S. Mickelsen, and L. Overzet. "Quantification of hemolysis rates from pulsed field ablation." European Heart Journal 45, Supplement_1 (2024). http://dx.doi.org/10.1093/eurheartj/ehae666.387.

Full text

Abstract:

Abstract Introduction Pulsed electric fields induce hemolysis of red blood cells as a dose-dependent effect of the electric field. Voltage pulsations induce a transmembrane potential across the cell membrane and either open up or create pores in the red cells. In isotonic conditions, the pores allow passage of potassium and sodium ions but not sucrose or hemoglobin, and leakage of ions leads to an osmotic imbalance which in turn causes a colloidal hemolysis of the red cells. Objective To quantify hemolysis rates during pulsed field ablation (PFA). Methods We created a computational model of PF

APA, Harvard, Vancouver, ISO, and other styles

35

Reddy, Vivek Y., Elad Anter, Petr Peichl, et al. "First-in-Human Clinical Series of a Novel Conformable Large-Lattice Pulsed Field Ablation Catheter for Pulmonary Vein Isolation." Europace, April 8, 2024. http://dx.doi.org/10.1093/europace/euae090.

Full text

Abstract:

Abstract Background/Aims Pulsed field ablation (PFA) has significant advantages over conventional thermal ablation of atrial fibrillation (AF). This first-in-human, single-arm trial to treat paroxysmal AF (PAF) assessed the efficiency, safety, pulmonary vein isolation (PVI) durability and one-year clinical effectiveness of an 8-Fr, large-lattice, conformable single-shot PFA catheter together with a dedicated electroanatomical mapping system. Methods After rendering the PV anatomy, the PFA catheter delivered monopolar, biphasic pulse trains (5-6 secs per application; ∼4 applications per PV). Th

APA, Harvard, Vancouver, ISO, and other styles

36

Yavin, Hagai, Erez Brem, Israel Zilberman, et al. "Circular Multielectrode Pulsed Field Ablation Catheter Lasso Pulsed Field Ablation." Circulation: Arrhythmia and Electrophysiology 14, no. 2 (2021). http://dx.doi.org/10.1161/circep.120.009229.

Full text

Abstract:

Background: Pulsed field ablation (PFA) is a nonthermal energy with potential safety advantages over radiofrequency ablation. This study investigated a novel PFA system—a circular multielectrode catheter (PFA lasso) and a multichannel generator designed to work with Carto 3 mapping system. Methods: A 7.5F bidirectional circular catheter with 10 electrodes and variable expansion was designed for PFA (biphasic, 1800 Volts). This study included a total of 16 swine used to investigate the following 3 experimental aims: Aim 1 examined the feasibility to create a right atrial ablation line of block

APA, Harvard, Vancouver, ISO, and other styles

37

Tomás, García-Sánchez, Gómez Barea Mario, and Ivorra Antoni. "A computational comparison of radiofrequency and pulsed field ablation in terms of lesion morphology in the cardiac chamber." Scientific Reports 12 (September 27, 2022). https://doi.org/10.1038/s41598-022-20212-9.

Full text

Abstract:

Scientific publication on numerical modelling of two different cardiac ablation techniques. The publication compares different aspects on lesion formation between Radiofrequency Ablation and Pulsed Field Ablation

APA, Harvard, Vancouver, ISO, and other styles

38

Verma, Atul, Samuel J. Asivatham, Thomas Deneke, Quim Castellvi, and Robert E. Neal. "Primer on Pulsed Electrical Field Ablation." Circulation: Arrhythmia and Electrophysiology 14, no. 9 (2021). http://dx.doi.org/10.1161/circep.121.010086.

Full text

Abstract:

Pulsed electrical field (PEF) energy is a promising technique for catheter ablation of cardiac arrhythmias. In this article, the key aspects that need to be considered for safe and effective PEF delivery are reviewed, and their impact on clinical feasibility is discussed. The most important benefit of PEF appears to be the ability to kill cells through mechanisms that do not alter stromal proteins, sparing sensitive structures to improve safety, without sacrificing cardiomyocyte ablation efficacy. Many parameters affect PEF treatment outcomes, including pulse intensity, waveform shape, and num

APA, Harvard, Vancouver, ISO, and other styles

39

Li, Yunhao, Fengqi Xuan, Daoyang Zhang, et al. "Effects of key parameters on pulsed field ablation of atrial fibrillation: potato experiments." Frontiers in Cardiovascular Medicine 12 (February 4, 2025). https://doi.org/10.3389/fcvm.2025.1525762.

Full text

Abstract:

AimsThe study aims to investigate the impact of key parameters of pulsed field ablation (PFA) on lesion depth, including voltage (V), pulse width (PW), number of pulses (P), and ablation number (N), using potato models.MethodsPotatoes are utilized as a display of the irreversible electroporation lesion. The key ablation parameters were varied systematically to explore its influences on lesion depths.Results and conclusionThe key ablation parameters have varying degrees of influence on lesion depths, following the order of PW&gt;V; V&gt;P; PW&gt;P; N&gt;P. Lesion depths increase

APA, Harvard, Vancouver, ISO, and other styles

40

Koruth, Jacob S., Kenji Kuroki, Iwanari Kawamura, et al. "Pulsed Field Ablation Versus Radiofrequency Ablation." Circulation: Arrhythmia and Electrophysiology 13, no. 3 (2020). http://dx.doi.org/10.1161/circep.119.008303.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Wang, Yujue, Tian’an Jiang, Liting Xie, et al. "Effect of pulsed field ablation on solid tumor cells and microenvironment." Frontiers in Oncology 12 (August 23, 2022). http://dx.doi.org/10.3389/fonc.2022.899722.

Full text

Abstract:

Pulsed field ablation can increase membrane permeability and is an emerging non-thermal ablation. While ablating tumor tissues, electrical pulses not only act on the membrane structure of cells to cause irreversible electroporation, but also convert tumors into an immune active state, increase the permeability of microvessels, inhibit the proliferation of pathological blood vessels, and soften the extracellular matrix thereby inhibiting infiltrative tumor growth. Electrical pulses can alter the tumor microenvironment, making the inhibitory effect on the tumor not limited to short-term killing,

APA, Harvard, Vancouver, ISO, and other styles

42

Koruth, Jacob S., and Moritz Nies. "Ventricular Pulsed-Field Ablation." JACC: Clinical Electrophysiology, July 2023. http://dx.doi.org/10.1016/j.jacep.2023.05.021.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Li, Xinzhong, Long Huang, Jianyong Li, Senlin Huang, and Yuegang Wang. "Tricuspid isthmus ablation with pulsed-field power by linear catheter: a case report." European Heart Journal - Case Reports, December 8, 2023. http://dx.doi.org/10.1093/ehjcr/ytad601.

Full text

Abstract:

Abstract Background Pulsed-field ablation using annular or petal-shaped catheters had been proven to be effective for achieving electrical isolation of pulmonary veins in patients with atrial fibrillation. However, the utilization of linear pulse-field power for treating atrial flutter has yet to been documented. Case summary In this report, we present a case involving the successful treatment of tricuspid isthmus dependent atrial flutter treated with a linear pulsed-field catheter. The patient, a 71-year-old male, presents with an ECG indicating atrial flutter. Subsequent electrophysiological

APA, Harvard, Vancouver, ISO, and other styles

44

Wu Xiao-Dong, Chen Yan-Zhou, Han Rui, Guo Yu-Yi, Zhuang Jie, and Shi Fu-Kun. "Study on the law of diffused bubbles generated by the high-voltage pulsed electric field in liquid." Acta Physica Sinica, 2023, 0. http://dx.doi.org/10.7498/aps.72.20230443.

Full text

Abstract:

Pulsed Electric Fields (PEFs) is a novel physical energy source for the treatment of atrial fibrillation and tumor ablation, which has advantages over traditional thermal ablation, such as non-thermal, short treatment time, tissue selectivity, and low contact pressure requirements. The diffusion bubbles generated during physical ablation may lead to gas embolism and silent cerebral events(SCE), with potential hazards such as tissue damage and cerebral ischemia. Previous studies have shown that the amount of bubbles generation is correlated with the electrical properties of the treated object,

APA, Harvard, Vancouver, ISO, and other styles

45

Haettasch, R., C. Baldauf, V. Tscholl, and G. Hindricks. "Hemolysis after atrial fibrillation ablation conducted with a new point-by-point pulsed field ablation device." Europace 27, Supplement_1 (2025). https://doi.org/10.1093/europace/euaf085.175.

Full text

Abstract:

Abstract Background/Introduction Pulsed field ablation (PFA) has gained traction in recent years as an alternative to thermal ablation techniques, such as radiofrequency (RF) and cryoballoon ablation (CBA), due to its non-inferior efficacy(1) and potential safety advantages in atrial fibrillation ablation (PVI). Cardiomyocytes are particularly susceptible to electroporation, whereas non-cardiac tissues are relatively resistant to the electrical fields used in this technique(2). However, there have been reports of hemolysis and even kidney injury resulting from hemolysis following PFA with a pe

APA, Harvard, Vancouver, ISO, and other styles

46

Meng, Fanchao, Shuqi Jin, and Nian Liu. "Cardiac selectivity in pulsed field ablation." Current Opinion in Cardiology, November 28, 2024. http://dx.doi.org/10.1097/hco.0000000000001183.

Full text

Abstract:

Purpose of review This review examines the selective cardiac injury induced by pulsed electric fields during atrial fibrillation ablation. It consolidates findings from both preclinical and clinical studies on cardiac selectivity and explores the potential mechanisms behind this selectivity. Recent findings Preclinical studies indicate that pulsed electric fields cause significantly more myocardial injury compared with other tissues. Clinical studies have similarly shown that complication rates for pulsed field ablation are notably lower than those for radiofrequency and cryoballoon ablation.

APA, Harvard, Vancouver, ISO, and other styles

47

La Fazia, V., N. P. Nicola Pierucci, P. C. Paolo Compagnucci, et al. "Organization of atrial fibrillation during pulsed field ablation." Europace 27, Supplement_1 (2025). https://doi.org/10.1093/europace/euaf085.432.

Full text

Abstract:

Abstract Background Pulse Field Ablation (PFA) has been acknowledged as an effective and safe tool for ablation of Atrial Fibrillation (AF). It is known that during AF ablation, the arrhythmia may organize into atrial flutter. The left atrial posterior wall is identified as a critical source of non-Pulmonary Vein (PV) triggers that facilitate maintenance of atrial fibrillation. Objective The purpose of this study is to investigate the phenomenon of atrial flutter organization from AF during the application of PFA. Methods This prospective multicentric study encompasses 248 consecutive patients

APA, Harvard, Vancouver, ISO, and other styles

48

Jacobs, Edward J., Pedro P. Santos, and Rafael V. Davalos. "Effects of Interphase and Interpulse Delays on Tissue Impedance and Pulsed Field Ablation." Annals of Biomedical Engineering, May 16, 2025. https://doi.org/10.1007/s10439-025-03757-4.

Full text

Abstract:

Abstract Purpose High-frequency irreversible electroporation (H-FIRE) is a pulsed field ablation (PFA) technique that employs a series of high-voltage, microseconds-long positive and negative pulses, separated by interphase (d1) and interpulse (d2) delays to non-thermally ablate tissue. Previous experimental and computational data suggest an impact of delays on nerve excitation and electrochemical effects. However, the impact of delays on PFA outcomes, such as change in resistance and ablation generation, has only recently started to be elucidated. Methods While recording the applied voltage a

APA, Harvard, Vancouver, ISO, and other styles

49

Verma, Atul, David E. Haines, Lucas V. Boersma, et al. "Pulsed Field Ablation for the Treatment of Atrial Fibrillation: PULSED AF Pivotal Trial." Circulation, March 6, 2023. http://dx.doi.org/10.1161/circulationaha.123.063988.

Full text

Abstract:

BACKGROUND: Pulsed field ablation uses electrical pulses to cause nonthermal irreversible electroporation and induce cardiac cell death. Pulsed field ablation may have effectiveness comparable to traditional catheter ablation while preventing thermally mediated complications. METHODS: The PULSED AF pivotal study (Pulsed Field Ablation to Irreversibly Electroporate Tissue and Treat AF) was a prospective, global, multicenter, nonrandomized, paired single-arm study in which patients with paroxysmal (n=150) or persistent (n=150) symptomatic atrial fibrillation (AF) refractory to class I or III ant

APA, Harvard, Vancouver, ISO, and other styles

50

Kautzner, Josef, Jana Haškova, Jakub Cvek, Marek Adamíra, and Petr Peichl. "Hypertrophic obstructive cardiomyopathy with recurrent ventricular tachycardias - from catheter ablation and stereotactic radiotherapy to heart transplant: a case report." European Heart Journal - Case Reports, July 30, 2024. http://dx.doi.org/10.1093/ehjcr/ytae379.

Full text

Abstract:

Abstract Background Management of hypertrophic obstructive cardiomyopathy (HOCM) is often challenging, depending on clinical manifestation. This case report illustrates the complex treatment of HOCM with associated recurrent ventricular arrhythmias. Case summary A 54-year-old female with HOCM diagnosed in 2012 underwent a failed attempt for alcohol septal ablation, implantation of an ICD, and repeated radiofrequency ablations (including ablation of the septal bulge to reduce LV obstruction). For VT recurrences, she had stereotactic arrhythmia radioablation with subsequent epicardial cryoablati

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!