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Dissertations / Theses on the topic 'Pure compounds'

Author: Grafiati

Published: 8 June 2024

Last updated: 31 July 2025

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1

Harvey, Ian. "Applications of enzymatic methods to the preparation of enantiomerically pure compounds." Thesis, University of Warwick, 1989. http://wrap.warwick.ac.uk/106588/.

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This thesis describes investigations in the field of biotransformations, concentrating on the mode of action of esterases and lipases, and the application of these systems to the production of enantiomerically pure compounds. The behaviour of pig liver esterase (PLE) in the presence of some commonly use alcohol and ketone cosolvents was examined. Methanol, ethanol and 2-butanone were found to be potent inhibitors of PLE. At low concentrations, acetone accelerated the rata of PLE catalysed hydrolysis, but is also inhibitory at higher concentrations. The effects of alcohols as product inhibitors

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2

Ellis, Michael Martin. "Formation of pure polycrystalline alpha-alumina fibers from an organo-metallic sol-gel." Thesis, Georgia Institute of Technology, 1992. http://hdl.handle.net/1853/20010.

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3

Carr, Jason A. "The Utilization of Enzymes in the Synthesis and Modification of Natural and NonNatural Compounds: A Chemo-Enzymatic Approach to Enantiomerically Pure Compounds." Scholar Commons, 2004. https://scholarcommons.usf.edu/etd/983.

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The employment of enzymes and whole cells has been important in many industries for centuries. However, it is only in the last 30 years that the use of enzymes for the synthesis of high-value fine chemicals has enjoyed increasing popularity. In fact, esterases and lipases are used almost routinely these days to provide optically active building blocks for the construction of imaginative new routes to chiral target molecules. The major topic of this work describes the utilization of enzymes (namely lipases) in the synthesis and modification of natural and non-natural compounds. Chapter 1 outlin

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4

Carr, Jason A. "The utilization of enzymes in the synthesis and modification of natural and non-natural compounds a chemo-enzymatic approach to enantiomerically pure compounds /." [Tampa, Fla.] : University of South Florida, 2004. http://purl.fcla.edu/fcla/etd/SFE0000420.

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5

Mullins, Paul Eric. "Application of COSMO-SAC to Solid Solubility in Pure and Mixed Solvent Mixtures for Organic Pharmacological Compounds." Thesis, Virginia Tech, 2007. http://hdl.handle.net/10919/31086.

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<p>In this work, we present two open literature databases, the VT-2005 Sigma Profile Database and the VT-2006 Solute Sigma Profile Database, that contain sigma profiles for 1,645 unique compounds. A sigma profile is a molecular-specific distribution of the surface-charge density, which enables the application of solvation-thermodynamic models to predict vapor-liquid and solid-liquid equilibria, and other properties. The VT-2005 Sigma Profile Database generally focuses on solvents and small molecules, while the VT-2006 Solute Sigma Profile Database primarily consists of larger, pharmaceutical

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6

Nalla, V. "Synthesis of optically pure pharamaceuticals employing aziridines / epoxides as chiral synthons and development of novel biologically active compounds based on benzopyran -4- ones." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2018. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/5854.

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7

Pradhan, Rajendra Sharad. "Formulation and in vitro release study of poly(DL-lactide) microspheres containing hydrophilic compounds, glycine and its homopeptides." Scholarly Commons, 1992. https://scholarlycommons.pacific.edu/uop_etds/2831.

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In view of current interest in several oligopeptide drugs currently being investigated for controlled implantable delivery, glycine, diglycine, triglycine, tetraglycine and pentaglycine were chosen as model compounds for encapsulation in biodegradable microspheres of DL-polylactide (DL-PLA) by a technique based on oil-in-oil emulsion and the solvent evaporation principle. A DL-polylactide concentration of 10.3% w/w and emulsifier (sorbitan sesquioleate) concentration of 0.3% v/v produced good yields of microspheres with excellent entrapment when processed under following conditions: emulsion t

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8

Abubakar, Ibrahim Babangida. "In vitro investigation on synergistic anticancer effects between vitamin E isomers, pure compounds and crude alkaloid plant extracts on human cancerous cells." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/35974/.

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Anticancer chemotherapeutic treatment using single dose has been limited due to drug resistance and potential metabolic degradation. For instance, high-dose tocotrienols undergo metabolic degradation that limits the availability of therapeutic dose thereby limiting the potency in vivo. Combined treatment of tocotrienols at low dosage has been suggested as alternative to circumventing this limitation. This study was designed to investigate the cytotoxic effects and subsequently the apoptotic mechanisms of individual doses and combined treatments at lower dosages of tocotrienols (delta and gamma

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9

Eckard, Phyllis R. "The Investigation of Primary and Secondary Modifiers in the Extraction and Separation of Neutral and Ionic Pharmaceutical Compounds with Pure and Modified Carbon Dioxide." Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/30500.

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A successful supercritical fluid extraction method includes removal of the analyte from the matrix into the bulk fluid as well as trapping or concentration of the analyte prior to analysis. In the first phase of this research, the trapping capacities of three solid-phase traps (glass beads, 50/50 (w/w) glass beads/octadecylsilica), 50/50 (w/w) Porapak Q®/glass beads) were determined as a function of trap composition for a mixture of components varying in polarity and volatility. The Porapak Q®/glass beads mixture was found to be the most successful solidphase investigated exhibiting the highes

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10

Vangani, Saroj. "Development of an in vitro dissolution model to predict the in vivo behavior of poorly soluble compounds." Scholarly Commons, 2010. https://scholarlycommons.pacific.edu/uop_etds/2412.

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One of the challenges of biopharmaceutics research is correlating in vitro drug release information with the in vivo drug profiles often known as in vitro-in vivo correlations (IVIVC). These have huge cost savings in pharmaceutical industry. This dissertation describes the development of a novel in vitro dissolution model that has been designed to evaluate the in vitro release of poorly water-soluble model compounds so as to predict their in vivo behavior. The flow through apparatus (USP 4) has been coupled with the compendial dissolution apparatus (USP 2). A bi-phasic dissolution medium has b

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11

Alajtal, Adel Imhemed. "Raman spectroscopic application for the analysis of organic compounds and minerals of astrobiological significance : the detection and discrimination of organic compounds and mineral analogues in pure and mixed samples of astrobiological significance using raman spectroscopy, XRD and scanning electron microscopy." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/4425.

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Raman spectroscopy has been used to characterise both organic and geological samples in order to build a database for the future characterization of biomarker molecules that are of astrobiological relevance. Characteristic geological features and hydrated minerals recently found on the surface of Mars by the NASA planetary rovers Spirit and Opportunity suggest that a possible biosphere could have once existed there. Analytical instrumentation protocols for the unequivocal detection of biomarkers in suitable geological matrices are critical for future unmanned explorations, including the forthc

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12

Alajtal, Adel I. "Raman spectroscopic application for the analysis of organic compounds and minerals of astrobiological significance. The detection and discrimination of organic compounds and mineral analogues in pure and mixed samples of astrobiological significance using raman spectroscopy, XRD and scanning electron microscopy." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/4425.

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Raman spectroscopy has been used to characterise both organic and geological samples in order to build a database for the future characterization of biomarker molecules that are of astrobiological relevance. Characteristic geological features and hydrated minerals recently found on the surface of Mars by the NASA planetary rovers Spirit and Opportunity suggest that a possible biosphere could have once existed there. Analytical instrumentation protocols for the unequivocal detection of biomarkers in suitable geological matrices are critical for future unmanned explorations, including the forthc

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13

Buen, Zachary. "Establishment of gas-phase thermochemical values of various small organic compounds and oligopeptides." Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/262.

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The thesis describes utilizing mass spectrometry and computational methods to study two groups of molecular systems: small organic molecules and oligopeptides. The gas-phase acidities were measured and the structures of the molecular species were calculated. The small molecules investigated included methylparaben, ibuprofen, and triclosan, all known to have some biological activity. The gas-phase acidity measurements made for these small molecules had the solvent and collisional gas pressures adjusted in order to observe their potential influences. The results obtained provide insight into the

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14

Nguyen, Hai Trung. "Transfert hydrique dans le milieu poreux réactif : Application à l’étude de séchage d’une pâte pure ettringitique au jeune âge." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSEI124/document.

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Les chapes autonivelantes sont souvent composées de ciment alumineux et de sulfate de calcium pour assurer une prise rapide. Le ciment alumineux est généralement à base de monocalcium aluminate (CA). Récemment, un nouveau ciment alumineux riche en mayénite (C12A7) a été conçu pour optimiser l’application des chapes par l’augmentation de la quantité d’ettringite formée. Le développement de l’hydratation au jeune âge (pendant les premières 24 heures) de ce type de produit est pourtant très peu connu. L’objectif principal de cette étude est d’évaluer l’interaction entre l’hydratation au jeune âge

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15

Ramírez-Vélez, Nicolás. "Parametrization of equations of state : definition of a methodology applicable to SAFT models for pure species (with and without association term) and evaluation of their influence on model performances." Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0020.

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Les modèles thermodynamiques sont au cœur des outils de modélisation en génie des procédés qui fournissent, d’une part, la description, tant qualitative que quantitative des équilibres de phase des mélanges complexes, et d’autres part, une mesure des propriétés énergétiques (enthalpies, entropies, capacités thermiques) nécessaires à l’établissement des bilans énergétique et exergétique. Ce travail s’intéresse en particulier aux équations d’état issues de la théorie statistique des fluides associés (SAFT) appliquées aux corps purs. Notre objectif principal est de proposer des méthodes de paramé

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16

Wiser, Lauren Sample. "Mechanisms of polymer adsorption in nanoparticle stabilization for poorly water soluble compounds." Scholarly Commons, 2011. https://scholarlycommons.pacific.edu/uop_etds/159.

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In this dissertation, the mechanisms of nanosuspension stabilization via polymer adsorption on nanoparticle surface were investigated. As the electrokinetic behavior and colloidal stability depend on the surface characteristics, altering the surface adsorbed polymers affords the different surface properties of nanoparticles and leads to the insight on the mechanism of nanoparticle stabilization. Drug nanosuspensions were prepared by wet milling of drug with water as medium and polymers as stabilizers. Block copolymers were evaluated based on varying the hydrophobic and hydrophilic amounts, pol

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17

Anderson, Michael D. 1980. "Novel Misfit Layer Systems: Synthesis and Characterization." Thesis, University of Oregon, 2011. http://hdl.handle.net/1794/12092.

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xxiv, 265 p. : ill. (some col.)<br>Stabilizing mechanisms and design considerations for generating misfit layer compounds with a variety of different structural motifs were explored using designed precursors consisting of elemental layers. Layer order in the precursor film and the behavior of binary reaction couples was used to avoid undesirable reaction intermediates. Electron diffraction patterns of CuCr2 Se4 were inconsistent with prior reports that this compound has the spinel structure and were more consistent with a hexagonal R 3 ̄ structure. STEM imaging also suggests CuCr2 Se4 prepa

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18

Park, Jongik. "Photoemission Study of the Rare Earth Intermetallic Compounds RNi2Ge2 (R=Eu, Gd)." Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2004. http://www.osti.gov/servlets/purl/835299-eRe3PQ/webviewable/.

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19

Yang, Ning. "Synchrotron Diffraction Studies of Spontaneous Magnetostriction in Rare Earth Transition Metal Compounds." Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2004. http://www.osti.gov/servlets/purl/835381-gxv1Km/webviewable/.

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20

Yanto, Yanto. "Evaluation of novel enoate reductases as potential biocatalyst for enantiomerically pure compound synthesis." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/39576.

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Asymmetric synthesis with biocatalyst has become an increasingly interesting and cost effective manufacturing process in fine chemicals, pharmaceuticals, and agrochemical intermediates. Enoate reductases from the Old Yellow Enzyme family offer high substrate efficiency, region, stereo-, and enantioselectivity in the catalyzed biotransformations. Asymmetric reduction of activated C=C bond is one of the most widely applied synthetic tools for the potential to generate up to two stereogenic centers in one step reaction. The thesis contributed to the development and characterization of the Old Yel

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21

Farris, Joshua Ryan. "Pure, compound, or composite humans : a constructive theological philosophical exploration of dualistic human ontology and origins." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.687270.

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As a work of constructive philosophical-theology, this disse11ation offers an account of theological anthropology by drawing from person-body substance dualism (e.g. pure, compound, and composite). To that end, I (i) philosophically defend substance dualism and parse out three kinds of substance dualism for exploration; (ii) show how substance dualism ontology persuasively accounts for the Scriptural narrative on human beings (the interface of philosophy and biblical-theology); (iii) defend person-body substance dualism as the most natural accounting for the New Testament teaching on the after

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22

Ayala, A. "Aspects of the SrO-CuO-TiO2 Ternary System Related to the Deposition of SrTiO3 and Copper-Doped SrTiO3 Thin-Film Buffer Layers." Washington, D.C : Oak Ridge, Tenn. : United States. Dept. of Energy ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2004. http://www.osti.gov/servlets/purl/836697-HiUEwz/native/.

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Thesis (Ph.D.); Submitted to the Univ. of New Mexico, Albuquerque, NM (US); 20 Dec 2004.<br>Published through the Information Bridge: DOE Scientific and Technical Information. "LA-14197-T" A. Ayala. 12/20/2004. Report is also available in paper and microfiche from NTIS.

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23

Giocondo, Maísa Pasquotto. "Avaliação da atividade apoptótica de substância pura isolada de Cryptocarya mandioccanna em células de carcinoma cervical imortalizadas pelo papilomavirus humano (HPV) /." Araraquara : [s.n.], 2007. http://hdl.handle.net/11449/89140.

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Orientador: Christiane Pienna Soares<br>Banca: Cleslei Fernando Zanelli<br>Banca: Andreimar Martins Soares<br>Resumo: Diversos estudos buscam identificar compostos com atividade seletiva para celulas tumorais e que possuam mecanismo de acao para desencadear a apoptose. Dentre as substancias isoladas de Cryptocarya sp, algumas estirilpironas, como a goniotalamina, apresentam atividade antiproliferativa e apoptogenica em diferentes linhagens celulares. No presente estudo, foram avaliadas as atividades citotoxica e pro-apoptotica da estirilpirona (criptomoscatona D2) isolada de Cryptocarya mandio

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24

Gosso, Jean-Pierre. "Spectroscopie Raman des excitations magnétiques dans les fluorures antiferromagnétiques cobalteux purs ou desordonnés par substitution." Paris 13, 1986. http://www.theses.fr/1986PA132007.

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Description des excitations magnétiques dans k::(2) cof::(4) et rb::(2) cof::(4) par un modèle multi-excitonique construit sur un hamiltonien comprenant champ cristallin, couplage spin-orbite et échange de heisenberg opérant sur le multiplet fondamental de l'ion cobalt en champ cristallin cubique. L'interprétation pour les composés désordonnés par substitution d'un ion magnétique mn se fait par fonctions de green ou modèle de champ moléculaire

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25

Giocondo, Maísa Pasquotto [UNESP]. "Avaliação da atividade apoptótica de substância pura isolada de Cryptocarya mandioccanna em células de carcinoma cervical imortalizadas pelo papilomavirus humano (HPV)." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/89140.

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Made available in DSpace on 2014-06-11T19:23:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-06-01Bitstream added on 2014-06-13T18:51:18Z : No. of bitstreams: 1 giocondo_mp_me_arafcf.pdf: 1362305 bytes, checksum: 5d252e88df73be4c96290a8a2c37f546 (MD5)<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>Universidade Estadual Paulista (UNESP)<br>Diversos estudos buscam identificar compostos com atividade seletiva para celulas tumorais e que possuam mecanismo de acao para desencadear a apoptose. Dentre as substancias isoladas de Cryptocarya sp, algumas estirilpi

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26

Folden, III Charles Marvin. "Development of odd-Z-projectile reactions for transactinide element synthesis." Berkeley, Calif. : Oak Ridge, Tenn. : Lawrence Berkeley National Laboratory ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2004. http://www.osti.gov/servlets/purl/843003-RuBpYI/native/.

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Doctoral Dissertation, Ph.D., University of California, Berkeley, Berkeley, California, USA.<br>Published through the Information Bridge: DOE Scientific and Technical Information. "LBNL--56749" Folden III, Charles Marvin. USDOE Director. Office of Science. Office of Nuclear Physics 11/04/2004. Report is also available in paper and microfiche from NTIS.

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27

Raimund, Stefan. "Sources and fluxes of volatile halogenated organic compounds in highly productive marine areas." Brest, 2010. http://www.theses.fr/2010BRES2022.

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Les Composés Halogénés Organiques Volatils (VHOC) sont des composès qui influencent largement la chimie atmosphérique et qui ont des sources naturelles et anthropiques. La production biogénique, les sources marines et les flux à l’interface air-mer de ces composés sont encore peu connues et ont fait l’objet de cette étude. Un système analytique et de nouveaux systèmes de prélèvement ont été développés. Lors d’un travail au laboratoire, il a été démontré que la communication plante-plante orchestre la formation des VHOC : une algue pré-traitée réagit moins intensément après réception d’un signa

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28

Chemla, Philippe. "Reactions diastereospecifiques de dienones fer-tricarbonyle : applications a la synthese d'alcools fonctionnalises optiquement purs." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13049.

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La methode de synthese utilisee permet d'acceder avec de bons rendements, a des composes de haute purete optique et de configuration donnee: alpha et gamma aldols et une delta -lactone fonctionnalisee en position 5. Des hydrocarbures optiquement actifs dont le centre asymetrique est eloigne de toute fonction, ont egalement ete synthetises par cette voie

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29

Maroly, Anupam. "The development of a sensitive method to study volatile organic compounds in gaseous emissions of lung cancer cell lines." Texas A&M University, 2005. http://hdl.handle.net/1969.1/2423.

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The ultimate objective of this research was to develop a low cost, reliable system that would lead to early detection of lung cancer. Tests involved the quantitation of gaseous metabolic emissions from immortalized lung cancer cell lines in order to correlate the chemical markers to be of cancerous origin. The specific aims of the project were the study of gas emissions in selected cancer cell lines and identification of volatile organic compounds (VOCs) in them. Disadvantages of earlier studies were that the measurements were not real time or state specific so that molecular identification wa

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30

Silva, Laiane Torres. "Revestimentos comestíveis à base de purê de manga e alginato de sódio para retenção de compostos voláteis em mangas minimamente processadas." Universidade Federal Rural do Semi-Árido, 2011. http://bdtd.ufersa.edu.br:80/tede/handle/tede/57.

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Made available in DSpace on 2016-08-12T19:15:20Z (GMT). No. of bitstreams: 1 LaianeTS_DISSERT.pdf: 999860 bytes, checksum: 8dc5867c70f5fc730dd9ff2cb969005b (MD5) Previous issue date: 2011-02-25<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The responses to mechanical damage caused by minimal processing can accelerate the loss of quality and modify the sensory attributes. Besides cooling, which is considered the main technique available to retard the undesirable effects of minimal processing, the use of barriers to O2/CO2 and water vapor can contribute in controlling senes

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31

Renouf, Philippe. "Synthèse asymétrique par hydrolyse enzymatique de diacétates de diénols prochiraux. Nouvelle voie d'accès à des composés optiquement purs." Rouen, 1995. http://www.theses.fr/1995ROUES048.

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Une nouvelle synthèse énantiosélective de composés chiraux originaux, possédant un centre stéréogénique quaternaire, a été mise au point, par hydrolyse enzymatique de diacétates de diénols prochiraux. En traitant les 2,4-diacétoxy-cyclohexa-1,4-diènes 3,3-disubstitués par le candida cylindracea lipase, nous obtenons les cétoacétates d'énols correspondants optiquement purs (ee>98%) avec des rendements chimiques élevés. Les excès énantiomériques ont été déterminés par RMN1H en présence de chélates de terre rare à ligands chiraux et/ou par CPG sur phase chirale. La configuration absolue de deux d

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32

PETIT, YVES. "Synthese d'hydroxy-2 esters enantiomeriquement purs a partir d'amino-2 acide : etude stereochimique de l'addition 1,4 d'organometalliques sur des systemes insatures-2,3 hydroxy-4." Paris 6, 1987. http://www.theses.fr/1987PA066578.

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Faux-Mallet, Marie-Sabine. "Extraction du gallium(iii) en milieu acide : comparaison des methodes d'extraction liquide-liquide et d'echange d'ions sur resines." Paris 6, 1988. http://www.theses.fr/1988PA066234.

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Comparaison des avantages et des inconvenients de l'extraction a l'aide de resines et de l'extraction liquide-liquide en vue de preciser leur domaine respectif d'utilisation en hydrometallurgie. Etude de la separation du gallium contenu dans les solutions d'attaque des minerais de zinc. Utilisation de la resine duolite es467 et pour l'extraction liquide-liquide de l'hydroxy-8 quinoleine et d'une alpha-hydroxy-oxime

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34

Vermassen, Aurore. "Adaptation de Staphylococcus xylosus à la matrice carnée, impact des composés nitrosés et utilisation des sources de fer." Thesis, Clermont-Ferrand 2, 2014. http://www.theses.fr/2014CLF22535/document.

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Staphylococcus xylosus est couramment utilisé comme ferment dans les produits carnés pour son rôle dans le développement de la flaveur et de la couleur. Beaucoup de propriétés technologiques ont été caractérisées in vitro. Cependant, les mécanismes moléculaires mis en place par cette bactérie pour s’adapter à une matrice carnée et aux composés nitrosés, fréquemment ajoutés dans ces produits, étaient méconnus. Pour identifier ces mécanismes, des approches de transcriptomique globale ont été mises en œuvre. S. xylosus survit dans un modèle viande en modulant l’expression de 55 % de ses gènes. Il

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35

Mailhos-Lefievre, Valèrie. "Etude de la pyrolyse des polyamides 11 et 12, purs et ignifugés par le système (decabromodiphenyle-trioxide d'antimoine) : mise en évidence d'une triple synergie brome-antimoine-azote." Paris 13, 1989. http://www.theses.fr/1989PA132003.

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36

Prouzet, Eric. "Ordre local dans de nouvelles formes de NiPS obtenues par chimie douce et par intercalation de lithium." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37617740f.

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Cherradi, Nabih Mohamed. "Propriétés de transport électronique à basse température d'alliages amorphes Au-Si et de multicouches Au/Si." Nancy 1, 1989. http://www.theses.fr/1989NAN10011.

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Étude de l'effet des interférences quantiques qui dominent à basse température les propriétés de transport électronique des systèmes désordonnés. Des alliages amorphes au::(X)SI::(1-X) et des multicouches Au-Si ont été préparées par évaporation sous vide d'or et de silicium

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38

Shi, Sheng-Hong, and 施昇宏. "The cytotoxicity of pure compounds from Danshen on U937 and HepG2 cancer cell lines." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/62619268773905619879.

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碩士<br>高苑科技大學<br>化工與生化工程研究所<br>101<br>Danshen is the most commonly used traditional Chinese traditional Chinese medicine. In modern medicine, Danshen can improve heart function, inhibit liver cell degeneration, expand coronary artery, increase coronary blood flow, and prevent myocardial ischemia. In recent years, tanshinone are also used in the treatment of cervical cancer, stomach cancer, hepatoma, lung cancer, leukemia and other diseases. Tanshinones may inhibit tumor cell proliferation, apoptosis and promote differentiation in some studies. In the study, we use U937 leukemia cells and HepG2

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Tung, Pei-Ling, and 董佩綾. "Induction of differentiation by pure compounds of Antrodia cinnamomea in human acute myeloid leukemia cells." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/98890116917118272582.

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碩士<br>國立中興大學<br>生命科學院碩士在職專班<br>100<br>Antrodia cinnamomea is a well known medicinal mushroom, and it has been shown to exhibit antioxidant and anticancer treatment effects. Cell differentiation is essential for normal growth and hematopoiesis. Inducing myelopoiesis can potentially serve as differentiation therapy for acute myeloid leukemia (AML). In this study, the ability of pure compounds purified from Antrodia cinnamomea to induce differentiation was studied in culture human myelocytic leukemia HL-60 and KG-1 cells. Treatment of HL-60 and KG-1 cells with Antcin B and Zhankuic acid C signif

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Huang, Ming-Hsien, and 黃銘賢. "A study on Cometabolic Degradation of Hydrocarbon Compounds by Pure and Mixed Cultures of Methanotrophic Bacteria." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/35760800623261829253.

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Chang, Mei Yin, and 張美音. "STUDY OF THE EXTRACTS OF PLANTAGO GENUS AND RELATED PURE COMPOUNDS FOR ANTICANCER、ANTIVIRAL AND IMMUNOMODULATORY ACTIVITIES." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/15054467145095441389.

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碩士<br>高雄醫學大學<br>醫學研究所<br>89<br>Plantago major Linn. (P. major) and Plantago asiatica Linn. (P. asiatica), are traditional Chinese herbal remedy and have been used to prevent breast cancer, conjunctivitis, hepatitis in Taiwan for hundreds of years. However, the mechanism of anti-tumor and anti-virus on both plants is still unclear. In the present study, the water crude extracts of P. major, P. asiatica and twelve related pure compounds were examined on various of herpesviruses, adenoviruses, leukemia and carcinoma cells. Results showed that P. major extract, P. asiatica extract, baicalin, and l

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Kuo, Li-Chen, та 郭力禎. "Pure compounds TR and AG within Chinese herbal medicines mediate glutamate receptors to attenuate Aβ-induced neuronal pathophysiology". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/j54snt.

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Ying, Jau-Wen, and 尹照雯. "Anti-enterovirus 71 activity and mechanism of Ge-Gen-Tang and its related pure compounds of Cinnamomum cassia." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/93855987117719325491.

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碩士<br>高雄醫學大學<br>醫學研究所<br>97<br>Abstract Enterovirus 71 (EV71) is endemic spread all of the year in the world. There is still no effective agent and vaccine could be used. In this study, we wanted to seek potential herbal candidate to prevent EV71 infection. Ge-Gen-Tang (GGT) is a traditional Chinese herbal remedy and commonly used to treat infectious disease including common cold. GGT has been found to be active against influenza virus, herpesvirus type 1, and EV71. Therefore, we tested the GGT and its related ingredients, Cinnamomum cassia Blume against EV71 by XTT reduction assay. The

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Chiu, Hung-Chih, and 邱泓智. "Anti-Alzheimer’s disease potential of extracts of Agaricus blazei and several pure compounds in PC-12 cell model." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/91527434602267018577.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>97<br>Alzheimer’s disease (AD) is the most common form of dementia caused by accumulation of amyloid-beta (Aβ) peptide in the brain, leading to elevated oxidative stress, inflammation, and neuronal loss in the brain. PC-12 cells, a neuronal-like cell line, were treated with Aβ to simulate the toxicity of Aβ towards neuron cells in AD. Several samples with high antioxidative activity including gallic acid, proanthocyanidin A2, arachidin-1, and sesamol, which is able to pass through the blood-brain-barrier (BBB), and samples with immunomodulating activities including t

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Chiu, Kun-Yuan, and 裘坤元. "The Effects and Underlying Mechanisms of the Pure Compounds Isolated from Antrodia cinnamomea on Human Urinary Tract Malignancies." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/70139918695148538856.

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博士<br>朝陽科技大學<br>應用化學系<br>104<br>Antrodia cinnamomea, a famous medicinal mushroom, known as Niuchang chih in Taiwan, exhibits anti-inflammatory, anti-oxidative, anti-angiogenic and hepatic protection properties. Several in vitro studies demonstrate the anti-cancer effects of Antrodia cinnamomea on hepatoma, lung cancer, as well as breast cancer. In this study, the effects of two active compound, Antrocin and Antcin H isolated from Antrodia cinnamomea against urological malignancies, both bladder cancer and renal cell carcinoma (RCC) were examined. Our study showed that treatment with cytotoxic

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Liu, Ya-Wei, and 劉亞薇. "Studies of Herbal Pure Compounds Tanshinone IIA and Osthole against Hepatic Fibrosis in Rats and Hepatic Stellate Cell Activation." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/84044215206360952234.

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博士<br>國立陽明大學<br>傳統醫藥研究所<br>103<br>Hepatic fibrosis is a dynamic process which ultimately leads to cirrhosis in many patients with chronic hepatic injury. However, progressive fibrosis is a reversible scarring response. Preventing activation and inflammation of hepatic stellate cells (HSCs) is the major strategy to treat hepatic fibrosis. Clinical therapies for hepatic diseases remain unsatisfactory. In the present studies, two approaches were used to investigate the potentials of Traditional Chinese Medicines (TCM) in treating hepatic fibrosis and HSC activation. Previously, our group has take

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Tzu-Ya and 吳慈雅. "Inhibitory effect of the pure compounds existing in plant polyphenols on high glucose induced human retinal pigment epithelial cell proliferation." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/67405674735402344418.

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碩士<br>中山醫學大學<br>生化暨生物科技研究所<br>96<br>High level of blood glucose could produce reactive oxygen species (ROS) to cause retinopathy. Our previous study demonstrated that Hibiscus sabdariffa aqueous extracts (HSE) and Hibiscus sabdariffa polyphenols extracts (HPE) could decelerate retinopathy in streptozotocin (STZ)-induced diabetic rats. In this study, we further examined the effect of protocatechuic acid, catechin, ferulic acid, gallic acid, quercetin and epicatechin existing in HSE in high glucose treating human retinal pigment epithelial (RPE) cells. We found that after treatment of high gluco

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"Part I. Synthetic studies of furanosesquiterpenoid tetrahydrolinderazulenes. Total synthesis of (plusmn)-echinofuran, and, Part II. Synthetic applications of chiral furyl boronates. Asymmetric synthesis of optically pure substituted furylamines." 2003. http://library.cuhk.edu.hk/record=b6073597.

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"July 2003."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2003.<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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Yang, Chien-Min, and 楊蒨旻. "The Study of Anti-Herpes Simplex Virus Activity and the Mode of action of Extracts and Pure Compounds Isolated from Phyllanthus urinaria L." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/09416854339698237698.

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博士<br>高雄醫學大學<br>藥學研究所<br>96<br>The fewer applicable of antiviral medicine, the emergence of resistant viruses, etc make a desire of searching new effective agent to manage viral infection. In this study, some extracts and pure compounds of Phyllanthus urinaria L. (Euphorbiaceae) were investigated for in vitro anti-HSV-1 and HSV-2 activities by plaque reduction assay. Results showed that the acetone, ethanol and methanol extracts inhibited HSV-2 infection more significance than that of HSV-1. All the three extracts showed more than 92.7% inhibiton against HSV-2 infection at concentration of 100

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Chun-KueiChen and 陳俊貴. "Streamwise Interaction of Burning Pure/Compound Drops." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/05572285389039370702.

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博士<br>國立成功大學<br>機械工程學系碩博士班<br>100<br>The spatial distribution of drops and the consequential interactions are influential parameters in spray combustion. Most of the available research papers on this subject were about lateral spacing effects or were performed in microgravity. Studies about upstream/downstream convective interaction of burning drops are scarce. In this study, single-component or compound drop strings of different spacing were observed in a high-temperature oxidizing environment for their flame transition, flame width variation and drop evaporation rate. As the drop fell into t

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