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Journal articles on the topic 'Purine and thiamine metabolism'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Björk, Glenn R., and Kristina Nilsson. "1-Methylguanosine-Deficient tRNA of Salmonella enterica Serovar Typhimurium Affects Thiamine Metabolism." Journal of Bacteriology 185, no. 3 (2003): 750–59. http://dx.doi.org/10.1128/jb.185.3.750-759.2003.

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ABSTRACT In Salmonella enterica serovar Typhimurium a mutation in the purF gene encoding the first enzyme in the purine pathway blocks, besides the synthesis of purine, the synthesis of thiamine when glucose is used as the carbon source. On carbon sources other than glucose, a purF mutant does not require thiamine, since the alternative pyrimidine biosynthetic (APB) pathway is activated. This pathway feeds into the purine pathway just after the PurF biosynthetic step and upstream of the intermediate 4-aminoimidazolribotide, which is the common intermediate in purine and thiamine synthesis. The

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2

Christian, Todd, and Diana M. Downs. "Defects in pyruvate kinase cause a conditional increase of thiamine synthesis inSalmonella typhimurium." Canadian Journal of Microbiology 45, no. 7 (1999): 565–72. http://dx.doi.org/10.1139/w99-042.

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As genomic sequence data become more prevalent, the challenges in microbial physiology shift from identifying biochemical pathways to understanding the interactions that occur between them to create a robust but responsive metabolism. One of the most powerful methods to identify such interactions is in vivo phenotypic analysis. We have utilized thiamine synthesis as a model to detect subtle metabolic interactions due to the sensitivity allowed by the small cellular requirement for this vitamin. Although purine biosynthesis produces an intermediate in thiamine synthesis, mutants blocked in the

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3

Johnson, Samanthia R., Kelsey L. Bentley, Scott Bowdridge, and Ibukun M. Ogunade. "213 Lipopolysaccharide-induced alterations in the liver metabolome of St. Croix and Suffolk sheep." Journal of Animal Science 102, Supplement_3 (2024): 407. http://dx.doi.org/10.1093/jas/skae234.464.

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Abstract The development of resistance in parasites due to overuse of anthelmintics has resulted in a marked decrease in the efficacy of these drug classes. Recent research efforts have focused on exploring alternatives such as selection for parasite-resistant breeds with the implication that immunocompetence may align with parasite resistance. Two breeds that are often investigated are the St. Croix (STC), a resistant hair breed, and Suffolk (SUF), a susceptible wool breed sheep. The liver has a vital role in metabolism in the body and metabolizes lipopolysaccharide (LPS), which triggers whol

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4

Sahu, Umakant, Elodie Villa, Colleen R. Reczek, et al. "Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis." Science 383, no. 6690 (2024): 1484–92. http://dx.doi.org/10.1126/science.adh2771.

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Cellular purines, particularly adenosine 5′-triphosphate (ATP), fuel many metabolic reactions, but less is known about the direct effects of pyrimidines on cellular metabolism. We found that pyrimidines, but not purines, maintain pyruvate oxidation and the tricarboxylic citric acid (TCA) cycle by regulating pyruvate dehydrogenase (PDH) activity. PDH activity requires sufficient substrates and cofactors, including thiamine pyrophosphate (TPP). Depletion of cellular pyrimidines decreased TPP synthesis, a reaction carried out by TPP kinase 1 (TPK1), which reportedly uses ATP to phosphorylate thia

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Decsi, Kincső, Mostafa Ahmed, Donia Abdul-Hamid, Roquia Rizk, and Zoltán Tóth. "Verification of Seed-Priming-Induced Stress Memory by Genome-Wide Transcriptomic Analysis in Wheat (Triticum aestivum L.)." Agronomy 15, no. 6 (2025): 1365. https://doi.org/10.3390/agronomy15061365.

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In line with the latest challenges, agriculture has many options to protect against stress conditions. Seed-priming treatment was applied to winter wheat genotype AG Hurrem with Dr. Green seed-priming fertilizer, which is a commonly used seed fertilizer containing macro- and microelements. Genome-wide transcriptomic analysis was performed to examine the effects of treatments. In seed-primed plants, defense response pathways such as purine and thiamine metabolism, glutathione pathway, and phenylpropanoid biosynthesis were activated. At the same time, photosynthesis and some cellular respiration

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Miles, Lindsay S., Nadia A. Ayoub, Jessica E. Garb, Robert A. Haney, and Brian C. Verrelli. "Ovarian Transcriptomic Analyses in the Urban Human Health Pest, the Western Black Widow Spider." Genes 11, no. 1 (2020): 87. http://dx.doi.org/10.3390/genes11010087.

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Due to their abundance and ability to invade diverse environments, many arthropods have become pests of economic and health concern, especially in urban areas. Transcriptomic analyses of arthropod ovaries have provided insight into life history variation and fecundity, yet there are few studies in spiders despite their diversity within arthropods. Here, we generated a de novo ovarian transcriptome from 10 individuals of the western black widow spider (Latrodectus hesperus), a human health pest of high abundance in urban areas, to conduct comparative ovarian transcriptomic analyses. Biological

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Li, Zijian, Hao Wu, Jing Fu, et al. "Eggshell Quality Traits and Transcriptome Gene Screening Between Yunnong and Jingfen Chicken Breeds." Biology 13, no. 12 (2024): 1048. https://doi.org/10.3390/biology13121048.

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The eggshell quality traits in avian species, including Yunnong chickens (YN), are crucial for commercial and breeding purposes. The use of advanced biotechnologies, such as gene sequencing, has become increasingly common for identifying genetic markers and comparing specific traits in livestock. However, genetic markers related to eggshell traits in YN chickens remain unexplored. This study aimed to compare eggshell quality traits and identify genetic markers in YN chickens versus commercial Jingfen chickens (JF). A total of 400 chicks (200 per breed) were reared for 300 days under controlled

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Assefa, Awraris Derbie, Seong-Hoon Kim, Vimalraj Mani, Hyoung-Rai Ko, and Bum-Soo Hahn. "Metabolic Analysis of the Development of the Plant-Parasitic Cyst Nematodes Heterodera schachtii and Heterodera trifolii by Capillary Electrophoresis Time-of-Flight Mass Spectrometry." International Journal of Molecular Sciences 22, no. 19 (2021): 10488. http://dx.doi.org/10.3390/ijms221910488.

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The cyst nematodes Heterodera schachtii and Heterodera trifolii, whose major hosts are sugar beet and clover, respectively, damage a broad range of plants, resulting in significant economic losses. Nematodes synthesize metabolites for organismal development and social communication. We performed metabolic profiling of H. schachtii and H. trifolii in the egg, juvenile 2 (J2), and female stages. In all, 392 peaks were analyzed by capillary electrophoresis time-of-flight mass spectrometry, which revealed a lot of similarities among metabolomes. Aromatic amino acid metabolism, carbohydrate metabol

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Haqberdiyeva, Mohinur Xo'jaberdi qizi, and Zamira Azimovna Satimova. "THE IMPORTANCE OF VITAMINS N, P AND C IN THE HUMAN BODY BASED ON THE INTEGRATION OF THE NATURAL SCIENCES." "Science and Innovation" international scientific journal 1, no. 1 (2022): 858–69. https://doi.org/10.5281/zenodo.6539301.

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<em>Vitamins are of vital biological importance to all living organisms in nature. Therefore, the composition, structure, processes, functions and use of vitamins are important. This is because vitamins and the micro and macro compounds they contain are involved in the body's absorption and metabolism. To date, more than 30 types of such vitamins have been identified and studied. The largest group of such vitamins is B vitamins. Of the B vitamins, vitamin B1 contains several trace elements, such as C, N, and O. The micro and macro elements in vitamin B1 are involved in performing the neces

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Liu, Xiyue, Guangtian Cao, Kaifan Qiu, Yingkun Dong, and Caihong Hu. "Lactobacillus plantarum Decreased Ammonia Emissions through Modulating Cecal Microbiotain Broilers Challenged with Ammonia." Animals 13, no. 17 (2023): 2739. http://dx.doi.org/10.3390/ani13172739.

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Probiotic supplementation has become a prominent method of decreasing ammonia emissions in poultry production. The present study was conducted to investigate the influence of Lactobacillus plantarum on ammonia emission, immune responses, antioxidant capacity, cecal microflora and short chain fatty acids, and serum metabolites in broilers challenged with ammonia. A total of 360 1-day-old yellow-feathered broilers were randomly divided into three treatment groups: birds fed with a basal diet (CON), a basal diet supplemented with ammonia (AN), and a basal diet supplemented with 2.5 × 108 CFU L. p

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Seman, Zulkifli Ahmad, Azrin Ahmad, Rabiatul Adawiah Zainal Abidin, et al. "TRANSCRIPTOME SEQUENCING OF LEPISANTHES FRUTICOSA TO DISCOVER SSR MARKERS." International Journal of Research -GRANTHAALAYAH 10, no. 1 (2022): 21–33. http://dx.doi.org/10.29121/granthaalayah.v10.i1.2022.4451.

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Lepisanthes fruticosa (ceri Terengganu) is one of the important underutilized fruit plants with high value of bioactive compounds and pharmacological properties. Current studies have focused mainly on the bioactive compounds which are essential for functional food and pharmaceutical applications. However, studies on the diversity and conservation of L. fruticosa are still scarce since genomic and genetic resources for this plant species are still lacking. In this study, RNA sequencing of L. fruticosa leaf was carried out using Illumina HiSeq to identify potential unigenes and simple sequence r

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Mahlare, Mary-Jane S., Lizex Husselmann, Muinat N. Lewu, Cecilia Bester, Francis B. Lewu, and Oluwafemi James Caleb. "Analysis of the Differentially Expressed Proteins and Metabolic Pathways of Honeybush (Cyclopia subternata) in Response to Water Deficit Stress." Plants 12, no. 11 (2023): 2181. http://dx.doi.org/10.3390/plants12112181.

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Honeybush (Cyclopia spp.) is a rich source of antioxidant properties and phenolic compounds. Water availability plays a crucial role in plant metabolic processes, and it contributes to overall quality. Thus, this study aimed to investigate changes in molecular functions, cellular components, and biological processes of Cyclopia subternata exposed to different water stress conditions, which include well-watered (as Control, T1), semi-water stressed (T2), and water-deprived (T3) potted plants. Samples were also collected from a well-watered commercial farm first cultivated in 2013 (T13) and then

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13

Allen, Shara, Julie L. Zilles, and Diana M. Downs. "Metabolic Flux in Both the Purine Mononucleotide and Histidine Biosynthetic Pathways Can Influence Synthesis of the Hydroxymethyl Pyrimidine Moiety of Thiamine in Salmonella enterica." Journal of Bacteriology 184, no. 22 (2002): 6130–37. http://dx.doi.org/10.1128/jb.184.22.6130-6137.2002.

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ABSTRACT Together, the biosyntheses of histidine, purines, and thiamine pyrophosphate (TPP) contain examples of convergent, divergent, and regulatory pathway integration. Mutations in two purine biosynthetic genes (purI and purH) affect TPP biosynthesis due to flux through the purine and histidine pathways. The molecular genetic characterization of purI mutants and their respective pseudorevertants resulted in the conclusion that <1% of the wild-type activity of the PurI enzyme was sufficient for thiamine but not for purine synthesis. The respective pseudorevertants were found to be informa

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14

Evangelistella, Chiara, Alessio Valentini, Riccardo Ludovisi, et al. "De novo assembly, functional annotation, and analysis of the giant reed (Arundo donax L.) leaf transcriptome provide tools for the development of a biofuel feedstock." Biotechnology for Biofuels 10, no. 1 (2017): 138. https://doi.org/10.1186/s13068-017-0828-7.

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<strong>Background: </strong> <i>Arundo donax</i> has attracted renewed interest as a potential candidate energy crop for use in biomass-to-liquid fuel conversion processes and biorefineries. This is due to its high productivity, adaptability to marginal land conditions, and suitability for biofuel and biomaterial production. Despite its importance, the genomic resources currently available for supporting the improvement of this species are still limited.<strong>Results: </strong>We used RNA sequencing (RNA-Seq) to de novo assemble and characterize the <i>A. donax</i> leaf transcriptome. The s

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15

Enos-Berlage, Jodi L., and Diana M. Downs. "Biosynthesis of the Pyrimidine Moiety of Thiamine Independent of the PurF Enzyme (Phosphoribosylpyrophosphate Amidotransferase) in Salmonella typhimurium: Incorporation of Stable Isotope-Labeled Glycine and Formate." Journal of Bacteriology 181, no. 3 (1999): 841–48. http://dx.doi.org/10.1128/jb.181.3.841-848.1999.

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ABSTRACT Genetic analyses have suggested that the pyrimidine moiety of thiamine can be synthesized independently of the first enzyme of de novo purine synthesis, phosphoribosylpyrophosphate amidotransferase (PurF), in Salmonella typhimurium. To obtain biochemical evidence for and to further define this proposed synthesis, stable isotope labeling experiments were performed with two compounds, [2-13C]glycine and [13C]formate. These compounds are normally incorporated into thiamine pyrophosphate (TPP) via steps in the purine pathway subsequent to PurF. Gas chromatography-mass spectrometry analyse

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16

Zilles, Julie L., T. Joseph Kappock, JoAnne Stubbe, and Diana M. Downs. "Altered Pathway Routing in a Class ofSalmonella enterica Serovar Typhimurium Mutants Defective in Aminoimidazole Ribonucleotide Synthetase." Journal of Bacteriology 183, no. 7 (2001): 2234–40. http://dx.doi.org/10.1128/jb.183.7.2234-2240.2001.

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ABSTRACT In Salmonella enterica serovar Typhimurium, purine nucleotides and thiamine are synthesized by a branched pathway. The last known common intermediate, aminoimidazole ribonucleotide (AIR), is formed from formylglycinamidine ribonucleotide (FGAM) and ATP by AIR synthetase, encoded by the purI gene in S. enterica. Reduced flux through the first five steps of de novo purine synthesis results in a requirement for purines but not necessarily thiamine. To examine the relationship between the purine and thiamine biosynthetic pathways, purI mutants were made (J. L. Zilles and D. M. Downs, Gene

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17

Beck, Brian J., and Diana M. Downs. "The apbE Gene Encodes a Lipoprotein Involved in Thiamine Synthesis in Salmonella typhimurium." Journal of Bacteriology 180, no. 4 (1998): 885–91. http://dx.doi.org/10.1128/jb.180.4.885-891.1998.

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ABSTRACT Thiamine pyrophosphate is an essential cofactor that is synthesized de novo in Salmonella typhimurium. The biochemical steps and gene products involved in the conversion of aminoimidazole ribotide (AIR), a purine intermediate, to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine have yet to be elucidated. We have isolated mutations in a new locus (Escherichia coli open reading frame designation yojK) at 49 min on the S. typhimurium chromosome. Two significant phenotypes associated with lesions in this locus (apbE) were identified. First,apbE purF double mutants

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18

Zilles, Julie L., and Diana M. Downs. "A Novel Involvement of the PurG and PurI Proteins in Thiamine Synthesis Via the Alternative Pyrimidine Biosynthetic (APB) Pathway in Salmonella typhimurium." Genetics 144, no. 3 (1996): 883–92. http://dx.doi.org/10.1093/genetics/144.3.883.

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Abstract Thiamine is thought to be synthesized by two alternative pathways, one involving the first four enzymes of the purine pathway and a second that can function independently of the purine pathway. Insertion mutations in purG and purl prevent thiamine synthesis through the alternative pyrimidine biosynthetic (APB) pathway under aerobic but not anaerobic growth conditions. In contrast, point mutations in purG and purl caused one of three distinct phenotypes: Pur− Apb−, Pur− Apb+, or Pur+ Apb−. Analysis of these three mutant classes demonstrated two genetically separable functions for PurG

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19

Bazurto, Jannell V., Nicholas J. Heitman, and Diana M. Downs. "Aminoimidazole Carboxamide Ribotide Exerts Opposing Effects on Thiamine Synthesis in Salmonella enterica." Journal of Bacteriology 197, no. 17 (2015): 2821–30. http://dx.doi.org/10.1128/jb.00282-15.

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ABSTRACTInSalmonella enterica, the thiamine biosynthetic intermediate 5-aminoimidazole ribotide (AIR) can be synthesizedde novoindependently of the early purine biosynthetic reactions. This secondary route to AIR synthesis is dependent on (i) 5-amino-4-imidazolecarboxamide ribotide (AICAR) accumulation, (ii) a functional phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthetase (PurC; EC 6.3.2.6), and (iii) methionine and lysine in the growth medium. Studies presented here show that AICAR is a direct precursor to AIRin vivo. PurC-dependent conversion of AICAR to AIR was recreatedin v

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Frodyma, Michael, Aileen Rubio, and D. M. Downs. "Reduced Flux through the Purine Biosynthetic Pathway Results in an Increased Requirement for Coenzyme A in Thiamine Synthesis in Salmonella enterica Serovar Typhimurium." Journal of Bacteriology 182, no. 1 (2000): 236–40. http://dx.doi.org/10.1128/jb.182.1.236-240.2000.

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ABSTRACT Work presented here establishes a connection between cellular coenzyme A (CoA) levels and thiamine biosynthesis in Salmonella enterica serovar Typhimurium. Prior work showed thatpanE mutants (panE encodes ketopantoate reductase) had a conditional requirement for thiamine or pantothenate. Data presented herein show that the nutritional requirement ofpanE mutants for either thiamine or pantothenate is manifest only when flux through the purine biosynthetic pathway is reduced. Further, the data show that under the above conditions it is the lack of thiamine pyrophosphate, and not decreas

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Petersen, Leslie, Jodi Enos-Berlage, and Diana M. Downs. "Genetic Analysis of Metabolic Crosstalk and Its Impact on Thiamine Synthesis in Salmonella typhimurium." Genetics 143, no. 1 (1996): 37–44. http://dx.doi.org/10.1093/genetics/143.1.37.

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Abstract The first five steps in de novo purine biosynthesis are involved in the formation of the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine. We show here that the first enzyme in de novo purine biosynthesis, PurF, is required for thiamine synthesis during aerobic growth on some but not other carbon sources. We show that PurF-independent thiamine synthesis depends on the recently described alternative pyrimidine biosynthetic (APB) pathway. Null mutations in zwf (encoding glucose-6-P dehydogenase), gnd (encoding gluconate-6-P dehydrogenase), purE (encoding aminoimidazo

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22

Ramos, Itzel, E. I. Vivas, and D. M. Downs. "Mutations in the Tryptophan Operon Allow PurF-Independent Thiamine Synthesis by Altering Flux In Vivo." Journal of Bacteriology 190, no. 3 (2007): 815–22. http://dx.doi.org/10.1128/jb.00582-07.

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ABSTRACT Phosphoribosyl amine (PRA) is an intermediate in purine biosynthesis and also required for thiamine biosynthesis in Salmonella enterica. PRA is normally synthesized by phosphoribosyl pyrophosphate amidotransferase, a high-turnover enzyme of the purine biosynthetic pathway encoded by purF. However, PurF-independent PRA synthesis has been observed in strains having different genetic backgrounds and growing under diverse conditions. Genetic analysis has shown that the anthranilate synthase-phosphoribosyltransferase (AS-PRT) enzyme complex, involved in the synthesis of tryptophan, can pla

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Dougherty, Michael, and Diana M. Downs. "The stm4066 Gene Product of Salmonella enterica Serovar Typhimurium Has Aminoimidazole Riboside (AIRs) Kinase Activity and Allows AIRs To Satisfy the Thiamine Requirement of pur Mutant Strains." Journal of Bacteriology 185, no. 1 (2003): 332–39. http://dx.doi.org/10.1128/jb.185.1.332-339.2003.

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ABSTRACT In bacteria the biosynthetic pathways for purine mononucleotides and the hydroxymethyl pyrimidine moiety of thiamine share five reactions that result in the formation of aminoimidazole ribotide, the last metabolite common to both pathways. Here we describe the characterization of a Salmonella enterica mutant strain that has gained the ability to efficiently use exogenous aminoimidazole riboside (AIRs) as a source of thiamine. The lesion responsible for this phenotype is a null mutation in a transcriptional regulator of the GntR family (encoded by stm4068). Lack of this protein derepre

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Block, Alisha M., Parker C. Wiegert, Sarah B. Namugenyi, and Anna D. Tischler. "Transposon sequencing reveals metabolic pathways essential for Mycobacterium tuberculosis infection." PLOS Pathogens 20, no. 3 (2024): e1011663. http://dx.doi.org/10.1371/journal.ppat.1011663.

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New drugs are needed to shorten and simplify treatment of tuberculosis caused by Mycobacterium tuberculosis. Metabolic pathways that M. tuberculosis requires for growth or survival during infection represent potential targets for anti-tubercular drug development. Genes and metabolic pathways essential for M. tuberculosis growth in standard laboratory culture conditions have been defined by genome-wide genetic screens. However, whether M. tuberculosis requires these essential genes during infection has not been comprehensively explored because mutant strains cannot be generated using standard m

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Bazurto, Jannell V., and Diana M. Downs. "Plasticity in the Purine–Thiamine Metabolic Network of Salmonella." Genetics 187, no. 2 (2010): 623–31. http://dx.doi.org/10.1534/genetics.110.124362.

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Zimmermann, H. "Extracellular purine metabolism." Drug Development Research 39, no. 3-4 (1996): 337–52. http://dx.doi.org/10.1002/(sici)1098-2299(199611/12)39:3/4<337::aid-ddr15>3.0.co;2-z.

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Pan, Xiaohua, Xuemei Nan, Liang Yang, Linshu Jiang, and Benhai Xiong. "Thiamine status, metabolism and application in dairy cows: a review." British Journal of Nutrition 120, no. 5 (2018): 491–99. http://dx.doi.org/10.1017/s0007114518001666.

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AbstractAs the co-enzyme of pyruvate dehydrogenase andα-ketoglutarate dehydrogenase, thiamine plays a critical role in carbohydrate metabolism in dairy cows. Apart from feedstuff, microbial thiamine synthesis in the rumen is the main source for dairy cows. However, the amount of ruminal thiamine synthesis, which is influenced by dietary N levels and forage to concentrate ratio, varies greatly. Notably, when dairy cows are overfed high-grain diets, subacute ruminal acidosis (SARA) occurs and results in thiamine deficiency. Thiamine deficiency is characterised by decreased ruminal and blood thia

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Claas, Kathy, Shara Weber, and Diana M. Downs. "Lesions in the nuo Operon, Encoding NADH Dehydrogenase Complex I, Prevent PurF-Independent Thiamine Synthesis and Reduce Flux through the Oxidative Pentose Phosphate Pathway inSalmonella enterica Serovar Typhimurium." Journal of Bacteriology 182, no. 1 (2000): 228–32. http://dx.doi.org/10.1128/jb.182.1.228-232.2000.

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ABSTRACT In Salmonella enterica serovar Typhimurium, PurF-independent thiamine synthesis (or alternative pyrimidine biosynthesis) allows strains, under some growth conditions, to synthesize thiamine in the absence of the first step in the purine biosynthetic pathway. Mutations have been isolated in a number of loci that prevent this synthesis and thus result in an Apb−phenotype. Here we identify a new class of mutations that prevent PurF-independent thiamine synthesis and show that they are defective in the nuo genes, which encode the major, energy-generating NADH dehydrogenase of the cell. Da

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Poggi, V., G. Rindi, C. Patrini, B. De Vizia, G. Longo, and G. Andria. "Studies on thiamine metabolism in thiamine-responsive megaloblastic anaemia." European Journal of Pediatrics 148, no. 4 (1989): 307–11. http://dx.doi.org/10.1007/bf00444120.

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Raivio, K. O., M. Kekomäki, and P. Mäenpää. "FRUCTOSE AND PURINE METABOLISM." Acta Medica Scandinavica 192, S542 (2009): 111–14. http://dx.doi.org/10.1111/j.0954-6820.1972.tb05324.x.

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AGARWAL, RAM P., RICHARD BELL, ANNE LILLQUIST, and RONALD McCAFFREY. "Purine Metabolism in Leukemia." Annals of the New York Academy of Sciences 451, no. 1 (1985): 160–68. http://dx.doi.org/10.1111/j.1749-6632.1985.tb27107.x.

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Aleshin, Vasily A., Artem V. Artiukhov, Thilo Kaehne, Anastasia V. Graf, and Victoria I. Bunik. "Daytime Dependence of the Activity of the Rat Brain Pyruvate Dehydrogenase Corresponds to the Mitochondrial Sirtuin 3 Level and Acetylation of Brain Proteins, All Regulated by Thiamine Administration Decreasing Phosphorylation of PDHA Ser293." International Journal of Molecular Sciences 22, no. 15 (2021): 8006. http://dx.doi.org/10.3390/ijms22158006.

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Coupling glycolysis and mitochondrial tricarboxylic acid cycle, pyruvate dehydrogenase (PDH) complex (PDHC) is highly responsive to cellular demands through multiple mechanisms, including PDH phosphorylation. PDHC also produces acetyl-CoA for protein acetylation involved in circadian regulation of metabolism. Thiamine (vitamin B1) diphosphate (ThDP) is known to activate PDH as both coenzyme and inhibitor of the PDH inactivating kinases. Molecular mechanisms integrating the function of thiamine-dependent PDHC into general redox metabolism, underlie physiological fitness of a cell or an organism

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Frodyma, Michael E., and Diana Downs. "The panE Gene, Encoding Ketopantoate Reductase, Maps at 10 Minutes and Is Allelic to apbA inSalmonella typhimurium." Journal of Bacteriology 180, no. 17 (1998): 4757–59. http://dx.doi.org/10.1128/jb.180.17.4757-4759.1998.

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ABSTRACT In Salmonella typhimurium, precursors to the pyrimidine moiety of thiamine are synthesized de novo by the purine biosynthetic pathway or the alternative pyrimidine biosynthetic (APB) pathway. TheapbA gene was the first locus defined as required for function of the APB pathway (D. M. Downs and L. Petersen, J. Bacteriol. 176:4858–4864, 1994). Recent work showed the ApbA protein catalyzes the NADPH-specific reduction of ketopantoic acid to pantoic acid. This activity had previously been associated with the pantothenate biosynthetic gene panE. Although previous reports placed panE at 87 m

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Gul-Hinc, Sylwia, Anna Michno, Marlena Zyśk, Andrzej Szutowicz, Agnieszka Jankowska-Kulawy, and Anna Ronowska. "Protection of Cholinergic Neurons against Zinc Toxicity by Glial Cells in Thiamine-Deficient Media." International Journal of Molecular Sciences 22, no. 24 (2021): 13337. http://dx.doi.org/10.3390/ijms222413337.

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Brain pathologies evoked by thiamine deficiency can be aggravated by mild zinc excess. Cholinergic neurons are the most susceptible to such cytotoxic signals. Sub-toxic zinc excess aggravates the injury of neuronal SN56 cholinergic cells under mild thiamine deficiency. The excessive cell loss is caused by Zn interference with acetyl-CoA metabolism. The aim of this work was to investigate whether and how astroglial C6 cells alleviated the neurotoxicity of Zn to cultured SN56 cells in thiamine-deficient media. Low Zn concentrations did not affect astroglial C6 and primary glial cell viability in

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Pavlova, O., S. Stepanenko, L. Chehivska, M. Sambon, L. Bettendorff, and Yu Parkhomenko. "Thiamine deficiency in rats affects thiamine metabolism possibly through the formation of oxidized thiamine pyrophosphate." Biochimica et Biophysica Acta (BBA) - General Subjects 1865, no. 11 (2021): 129980. http://dx.doi.org/10.1016/j.bbagen.2021.129980.

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Archambault, Anne-Sophie, Lauar de Brito Monteiro, Lucas Starchuck, et al. "Purine catabolism regulates the production of IL-1beta in macrophages." Journal of Immunology 212, no. 1_Supplement (2024): 0286_4533. http://dx.doi.org/10.4049/jimmunol.212.supp.0286.4533.

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Abstract Activation of pro-inflammatory (M1-like) macrophages leads to the production of pro-inflammatory cytokines, such as IL-1b, TNFa and IL-6. Those cytokines are important in the control of infections, but overproduction can lead to chronic inflammation. M1-like macrophages undergo metabolic remodeling, including the upregulation of purine metabolism. Using inhibitors of purine breakdown or purine synthesis, we aimed to identify the role of purine metabolism in M1-like macrophage function. Blocking purine synthesis or purine breakdown did not affect the frequency of CD80+CD86+iNOS+macroph

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Pacei, Federico, Antonella Tesone, Nazzareno Laudi, et al. "The Relevance of Thiamine Evaluation in a Practical Setting." Nutrients 12, no. 9 (2020): 2810. http://dx.doi.org/10.3390/nu12092810.

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Thiamine is a crucial cofactor involved in the maintenance of carbohydrate metabolism and participates in multiple cellular metabolic processes. Although thiamine can be obtained from various food sources, some common food groups are deficient in thiamine, and it can be denatured by high temperature and pH. Additionally, different drugs can alter thiamine metabolism. In addition, the half-life of thiamine in the body is between 1 and 3 weeks. All these factors could provide an explanation for the relatively short period needed to develop thiamine deficiency and observe the consequent clinical

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Ramos, I., and Diana M. Downs. "Anthranilate Synthase Can Generate Sufficient Phosphoribosyl Amine for Thiamine Synthesis in Salmonella enterica." Journal of Bacteriology 185, no. 17 (2003): 5125–32. http://dx.doi.org/10.1128/jb.185.17.5125-5132.2003.

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ABSTRACT In bacteria, the biosynthetic pathway for the hydroxymethyl pyrimidine moiety of thiamine shares metabolic intermediates with purine biosynthesis. The two pathways branch after the compound aminoimidazole ribotide. Past work has shown that the first common metabolite, phosphoribosyl amine (PRA), can be generated in the absence of the first enzyme in purine biosynthesis, PurF. PurF-independent PRA synthesis is dependent on both strain background and growth conditions. Standard genetic approaches have not identified a gene product singly responsible for PurF-independent PRA formation. T

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Millichap, J. Gordon. "Purine Metabolism and Rett Syndrome." Pediatric Neurology Briefs 10, no. 1 (1996): 7. http://dx.doi.org/10.15844/pedneurbriefs-10-1-11.

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Jyssum, Sidsel. "PURINE METABOLISM IN NEISSERIA MENINGITIDIS." Acta Pathologica Microbiologica Scandinavica Section B Microbiology and Immunology 82B, no. 4 (2009): 508–20. http://dx.doi.org/10.1111/j.1699-0463.1974.tb02359.x.

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Jyssum, Sidsel. "PURINE METABOLISM IN NEISSERIA MENINGITIDIS:." Acta Pathologica Microbiologica Scandinavica Section B Microbiology and Immunology 82B, no. 6 (2009): 885–94. http://dx.doi.org/10.1111/j.1699-0463.1974.tb02387.x.

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Copelan, E. A., K. S. Waddell, S. C. Johnson, and L. Mathes. "Purine Metabolism in Feline Lymphomas." Veterinary Pathology 27, no. 2 (1990): 117–21. http://dx.doi.org/10.1177/030098589002700207.

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DeMoll, E., and T. Auffenberg. "Purine metabolism in Methanococcus vannielii." Journal of Bacteriology 175, no. 18 (1993): 5754–61. http://dx.doi.org/10.1128/jb.175.18.5754-5761.1993.

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Krug, E. C., J. J. Marr, and R. L. Berens. "Purine Metabolism in Toxoplasma gondii." Journal of Biological Chemistry 264, no. 18 (1989): 10601–7. http://dx.doi.org/10.1016/s0021-9258(18)81663-5.

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Donck, Kris. "Purine metabolism in the heart." Pharmacy World & Science 16, no. 3 (1994): 166. http://dx.doi.org/10.1007/bf01877490.

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Suchail, S., M. E. Sarciron, and A. F. Petavy. "Purine metabolism in Echinococcus multilocularis." Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 120, no. 4 (1998): 633–37. http://dx.doi.org/10.1016/s0305-0491(98)10054-8.

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JYSSUM, SIDSEL. "PURINE METABOLISM IN NEISSERIA MENINGITIDIS." Acta Pathologica Microbiologica Scandinavica Section B Microbiology 83B, no. 5 (2009): 397–406. http://dx.doi.org/10.1111/j.1699-0463.1975.tb00118.x.

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JYSSUM, SIDSEL, and KAARE JYSSUM. "PURINE METABOLISM IN NEISSERIA MENINGITIDIS." Acta Pathologica Microbiologica Scandinavica Section B Microbiology 83B, no. 5 (2009): 407–15. http://dx.doi.org/10.1111/j.1699-0463.1975.tb00119.x.

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Donck, Kris. "Purine metabolism in the heart." Pharmacy World & Science 16, no. 2 (1994): 69–76. http://dx.doi.org/10.1007/bf01880658.

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Suzuki, Takeo, Hiroshi Ashihara, and George R. Waller. "Purine and purine alkaloid metabolism in Camellia and Coffea plants." Phytochemistry 31, no. 8 (1992): 2575–84. http://dx.doi.org/10.1016/0031-9422(92)83590-u.

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