Relevant bibliographies by topics / Purine nucleoside phosphorylase. eng

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Academic literature on the topic 'Purine nucleoside phosphorylase. eng'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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Journal articles on the topic "Purine nucleoside phosphorylase. eng"

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Bzowska, Agnieszka, Lucyna Magnowska, and Zygmunt Kazimierczuk. "Synthesis of 6-Aryloxy- and 6-Arylalkoxy-2-chloropurines and Their Interactions with Purine Nucleoside Phosphorylase from Escherichia coli." Zeitschrift für Naturforschung C 54, no. 12 (1999): 1055–67. http://dx.doi.org/10.1515/znc-1999-1210.

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The phase transfer method was applied to perform the nucleophilic substitution of 2,6- dichloropurines by modified arylalkyl alcohol or phenols. Since under these conditions only the 6-halogen is exchanged, this method gives 2-chloro-6-aryloxy- and 2-chloro-6-arylalkoxypurines. 2-Chloro-6-benzylthiopurine was synthesized by alkylation of 2-chloro-6-thiopurine with benzyl bromide. The stereoisomers of 2-chloro-6-(1-phenyl-1-ethoxy)purine were obtained from R- and S-enantiomers of sec.-phenylethylalcohol and 2,6-dichloropurine. All derivatives were tested for inhibition with purified hexameric E
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Arpaia, Enrico, Patricia Benveniste, Antonio Di Cristofano, et al. "Mitochondrial Basis for Immune Deficiency." Journal of Experimental Medicine 191, no. 12 (2000): 2197–208. http://dx.doi.org/10.1084/jem.191.12.2197.

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We generated purine nucleoside phosphorylase (PNP)-deficient mice to gain insight into the mechanism of immune deficiency disease associated with PNP deficiency in humans. Similar to the human disease, PNP deficiency in mice causes an immunodeficiency that affects T lymphocytes more severely than B lymphocytes. PNP knockout mice exhibit impaired thymocyte differentiation, reduced mitogenic and allogeneic responses, and decreased numbers of maturing thymocytes and peripheral T cells. T lymphocytes of PNP-deficient mice exhibit increased apoptosis in vivo and higher sensitivity to gamma irradiat
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Gandhi, Varsha, John M. Kilpatrick, William Plunkett, et al. "A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)." Blood 106, no. 13 (2005): 4253–60. http://dx.doi.org/10.1182/blood-2005-03-1309.

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The discovery of purine nucleoside phosphorylase (PNP) deficiency and T lymphocytopenia suggested that inhibition of this enzyme could serve as a therapeutic target. Inhibitors of PNP failed until structure-based synthesis of immucillin-H (BCX-1777, forodesine), a transition-state analog of PNP. The picomolar potency for PNP, T cell-selective cytotoxicity, and animal studies provided the rationale for use of forodesine in T-cell malignancies. Five patients were treated with an intravenous infusion of forodesine (40 mg/m2) on day 1; treatment continued on day 2; forodesine was administered ever
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Nguyen, B. T., and W. Sadée. "Compartmentation of guanine nucleotide precursors for DNA synthesis." Biochemical Journal 234, no. 2 (1986): 263–69. http://dx.doi.org/10.1042/bj2340263.

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We have studied the kinetics of guanine incorporation into DNA in mouse T-lymphoma (S-49) mutant cells [PNPase (purine-nucleoside phosphorylase)- and HGPRTase (hypoxanthine: guanine phosphoribosyltransferase)-deficient] that are incapable of converting dGuo (deoxyguanosine) to Gua (guanine) ribonucleotides. Of the two possible pathways for an exogenous guanine source to reach DNA, firstly: dGuo→dGMP→dGDP→dGTP and secondly: Gua→GMP→GDP→dGDP→dGTP only the second pathway was found to be functional in providing guanine for DNA replication, although deoxyguanosine readily produced toxic cellular dG
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Pogosian, L. H., and J. I. Akopian. "Purine nucleoside phosphorylase." Biomeditsinskaya Khimiya 59, no. 5 (2013): 483–97. http://dx.doi.org/10.18097/pbmc20135905483.

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Purine nucleoside phosphorylase (PNP) is one of the most important enzymes of the purine metabolism, wich promotes the recycling of purine bases. Nowadays is the actual to search for effective inhibitors of this enzyme which is necessary for creation T-cell immunodeficient status of the organism in the organs and tissues transplantation, and chemotherapy of a number pathologies as well. For their successful practical application necessary to conduct in-depth and comprehensive study of the enzyme, namely a structure, functions, and an affinity of the reaction mechanism. In the review the contem
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Furman, Richard R., Varsha V. Gandhi, J. Claude Bennett, Shanta Bantia, and J. Michael Kilpatrick. "Intravenous Forodesine (BCX-1777), a Novel Purine Nucleoside Phosphorylase (PNP) Inhibitor, Demonstrates Clinical Activity in Phase I/II Studies in Patients with B-Cell Acute Lymphoblastic Leukemia." Blood 104, no. 11 (2004): 2743. http://dx.doi.org/10.1182/blood.v104.11.2743.2743.

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Abstract Forodesine is a potent, specific transition-state analog inhibitor of PNP with clinical activity in T-cell malignancies. Pharmacodynamic studies support that this anti-leukemic effect is mediated through the accumulation of plasma 2′-deoxyguanosine (dGuo) and intracellular Dgtp. In vitro studies indicated that B-cell acute lymphoblastic leukemia (B-ALL) cells can also accumulate Dgtp. These preclinical data led to a phase I/II multicenter dose-escalation study to evaluate forodesine in pts with various hematologic malignancies. 15 pts were treated with forodesine, including 6 with B-A
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Montgomery, John A. "Inhibitors of purine nucleoside phosphorylase." Expert Opinion on Investigational Drugs 3, no. 12 (1994): 1303–13. http://dx.doi.org/10.1517/13543784.3.12.1303.

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Pogosian, L. H., L. S. Nersesova, M. G. Gazariants, Z. S. Mkrtchian, and J. I. Akopian. "Some inhibitors of purine nucleoside phosphorylase." Biomeditsinskaya Khimiya 57, no. 5 (2011): 526–34. http://dx.doi.org/10.18097/pbmc20115705526.

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Purine nucleoside phosphorylase (PNP) catalyzes reversible phosphorolysis of purine deoxy- and ribonucleosides with formation (d)Rib-1-P and corresponding bases. PNP plays a leading role in the cell metabolism of nucleosides and nucleotides, as well as in maintaining the immune status of an organism. The major aim of the majority of studies on the PNP is the detection of highly effective inhibitors of this enzyme, derivatives of purine nucleosides used in medicine as immunosuppressors, which are essential for creating selective T-cell immunodeficiency in a human body for organ and tissue trans
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Erion, Mark D., Johanna D. Stoeckler, Wayne C. Guida, and Richard L. Walter. "Purine Nucleoside Phosphorylase. 2. Catalytic Mechanism†." Biochemistry 36, no. 39 (1997): 11735–48. http://dx.doi.org/10.1021/bi961970v.

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Šedivá, Katarina, Ivan Votruba, Antonín Holý, and Ivan Rosenberg. "Purine nucleoside phosphorylase: Isolation and characterization." Collection of Czechoslovak Chemical Communications 55, no. 12 (1990): 2987–99. http://dx.doi.org/10.1135/cccc19902987.

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Purine nucleoside phosphorylase (PNP) from mouse leukemia cells L1210 was purified to homogeneity by a combination of ion exchange and affinity chromatography using AE-Sepharose 4B and 9-(p-succinylaminobenzyl)hypoxanthine as the matrix and the ligand, respectively. The native enzyme has a molecular weight of 104 000 and consists of three subunits of equal molecular weight of 34 000. The results of isoelectric focusing showed that the enzyme is considerably microheterogeneous over the pI-range 4.0-5.8 and most likely consists of eight isozymes. The temperature and pH-optimum of phosphorolysis,
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Dissertations / Theses on the topic "Purine nucleoside phosphorylase. eng"

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Silva, Diego Oliveira Nolasco da. "Estrutura cristalográfica da Purina nucleosídeo foslorilase do Mycobacterium tuberculosis /." São José do Rio Preto : [s.n.], 2005. http://hdl.handle.net/11449/87508.

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Orientador: Walter Filgueira de Azevedo Júnior<br>Banca: Luis Fernando Delboni<br>Banca: Fernanda Canduri<br>Resumo: A Purina Nucleosídeo Fosforilase (PNP) catalisa a fosforólise de nucleosídeos de purina para suas respectivas bases e açucares (ribose ou desoxirribose) 1-fosfato. A PNP desempenha uma função central no metabolismo das purinas, normalmente operando na via de recuperação do DNA das células. Mais ainda, a PNP cliva ligações glicosídicas com inversão da configuração para produzir a-ribose 1-fosfato. Acredita-se que no organismo do Mycobacterium tuberculosis a PNP desempenha tarefas
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Kavianipour, Mohammad. "Myocardial energy metabolism in ischemic preconditioning, role of adenosine catabolism." Doctoral thesis, Umeå University, Public Health and Clinical Medicine, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-14.

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<p>Brief episodes of ischemia and reperfusion render the myocardium more resistant to necrosis from a subsequent, otherwise lethal ischemic insult. This phenomenon is called ischemic preconditioning(IP). Today, much is known about the signalling pathways involved in IP; however, the details of the final steps leading to cardioprotection, remain elusive. Adenosine (a catabolite of ATP) plays a major role in the signalling pathways of IP. Following IP there is an unexplained discrepancy between an increased adenosine production (evidenced by increased 5’-nucleotidase activity) and the successive
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Rule, S. A. R. "Synchrotron X-radiation protein crystallography and its use in the crystal structure determination of purine nucleoside phosphorylase." Thesis, Keele University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235339.

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Souza, Juliana Roberta Torini de. "Caracterização estrutural e funcional de duas Nucleosídeo Fosforilases de Schistosoma mansoni." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-26102016-153439/.

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As doenças parasitárias são uma das maiores causas de morte em países em desenvolvimento, e recebem pouca ou nenhuma atenção das indústrias farmacêuticas para o desenvolvimento de terapias. Causada pelo parasita Schistosoma mansoni a esquistossomose mansônica afeta aproximadamente 259 milhões de pessoas no mundo sendo aproximadamente 6 milhões somente no Brasil. O S. mansoni não possui a via \"de novo\" para a biossíntese de bases púricas e depende integralmente da via de salvação para o suprimento dessas bases, portanto, essa via é um alvo em potencial. Agentes capazes de bloquear a atividade
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Alvarez, Frédéric. "Synthèse de dérivés benzimidazole-4,7-diones et imidazo[4,5-g]quinoléine-4,9 diones, inhibiteurs potentiels de la purine nucléoside phosphorylase issue de Toxoplasma gondii." Lyon 1, 2002. http://www.theses.fr/2002LYO1T197.

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La 4e de couverture indique : "La toxoplasmose est une maladie parasitaire dont l'agent infectieux est Toxoplasma gondii. La purine nucléoside phosphorylase (PNP), une enzyme prenant part au métabolisme des purines, est essentielle au développement de ce parasite. Après une analyse des données de la littérature concernant les inhibiteurs connus de PNP, il nous a semblé intéressant de mettre au point des voies d'accès à de nouveaux inhibiteurs potentiels, de la famille des 2,3-dihydrobenzimidazole-4,7-diones, des benzimidazole-4,7-diones et des imidazo[4,5-g]quinoléine-4,9-diones. Dans le cas d
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Martins, Nádia Helena 1982. "Estudos estruturais e biofísicos da enzima purina nucleosídeo fosforilase hexamérica de Bacillus subtilis." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317143.

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Orientador: Mário Tyago Murakami<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-20T16:32:04Z (GMT). No. of bitstreams: 1 Martins_NadiaHelena_D.pdf: 33217097 bytes, checksum: 6cbd9ad5dcfddd06e2357b3c680cd3f6 (MD5) Previous issue date: 2011<br>Resumo: A enzima purina nucleosídeo fosforilase hexamérica de Bacillus subtilis (BsPNP233) c uma nucleosídeo fosforilase do tipo 1 , responsável pela catalise reversível da reação de guebra de urn nucleosídeo em base nitrogenada e ribose-1-fosfato na via de salvação de purinas. Essa e
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Silva, Diego Oliveira Nolasco da [UNESP]. "Estrutura cristalográfica da Purina nucleosídeo foslorilase do Mycobacterium tuberculosis." Universidade Estadual Paulista (UNESP), 2005. http://hdl.handle.net/11449/87508.

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Made available in DSpace on 2014-06-11T19:22:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2005-08-18Bitstream added on 2014-06-13T20:29:19Z : No. of bitstreams: 1 silva_don_me_sjrp.pdf: 1054782 bytes, checksum: 832047dd271670cc0bc6debdbd5dc8d8 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A Purina Nucleosídeo Fosforilase (PNP) catalisa a fosforólise de nucleosídeos de purina para suas respectivas bases e açucares (ribose ou desoxirribose) 1-fosfato. A PNP desempenha uma função central no metabolismo das purinas, normalmente operando na via de recuper
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Browning, Luke Wayne. "StCKP and potato tuber dormancy." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275074.

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Monsalve, Monica Soto. "Determinação estrutural por difração de raios X de pirrolidinas poliidroxiladas com potencial atividade inibidora de purina nucleosídeo fosforilase." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-02102017-145525/.

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Foram determinadas por meio de difração de raios x as estruturas de cinco compostos azaçúcares. Foram estudadas as interações envolvidas na formação das redes cristalinas em cada um dos compostos analisados. Foi encontrado que nos compostos azaçúcares estudados, as interações principais são as ligações de hidrogênio do tipo C-H···O e C-H···&pi;. Este comportamento foi verificado usando ferramentas como as superfícies de Hirshfeld e os gráficos de impressão digital. Realizou-se o estudo de docking molecular dos compostos azaçúcares com respeito à enzima purina nucleosídeo fosforilase (PNP). Foi
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Ranjbarian, Farahnaz. "Targets and strategies for drug development against human African sleeping sickness." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-131074.

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Trypanosoma brucei is a causative agent of African sleeping sickness. It is an extracellular parasite which circulates in the blood, lymph and eventually invades the central nervous system. There is a great need for new medicines against the disease and specific properties of nucleoside kinases in the pathogen can be exploited as targets for chemotherapy.  T. brucei contains a gene where two thymidine kinase sequences are fused into a single open reading frame. These types of tandem thymidine kinases were found only in different types of parasites, which made us to believe that it might be ben
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Book chapters on the topic "Purine nucleoside phosphorylase. eng"

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Schomburg, Dietmar, and Dörte Stephan. "Purine-nucleoside phosphorylase." In Enzyme Handbook 12. Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61117-9_207.

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Stoeckler, Johanna D., and Robert E. Parks. "Purine Nucleoside Phosphorylase." In Methods Used in Adenosine Research. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-4886-3_8.

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Braun-Falco, Markus, Henry J. Mankin, Sharon L. Wenger, et al. "Purine Nucleoside Phosphorylase Deficiency." In Encyclopedia of Molecular Mechanisms of Disease. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_1508.

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Zhang, Yang, and Steven E. Ealick. "Chapter 3. Purine Nucleoside Phosphorylase." In Computational and Structural Approaches to Drug Discovery. Royal Society of Chemistry, 2007. http://dx.doi.org/10.1039/9781847557964-00047.

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Wielgus-Kutrowska, Beata, Agnieszka Bzowska, David Shugar, et al. "cellulomonas sp. Purine Nucleoside Phosphorylase (PNP)." In Advances in Experimental Medicine and Biology. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5381-6_51.

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Lewis, Roger A., and Robert K. Haag. "Purine Nucleoside Phosphorylase of Bovine Liver Mitochondria." In Advances in Experimental Medicine and Biology. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-7703-4_41.

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Ammann, Arthur J. "Immunological Aberrations in Purine Nucleoside Phosphorylase Deficiencies." In Ciba Foundation Symposium 68 - Enzyme Defects and Immune Dysfunction. John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470720516.ch5.

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Kulikowska, E., A. Bzowska, A. Holy, L. Magnowska, and D. Shugar. "Antiviral Acyclic Nucleoside Phosphonate Analogues as Inhibitors of Purine Nucleoside Phosphorylase." In Advances in Experimental Medicine and Biology. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5381-6_143.

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Traut, Thomas W., Patricia A. Ropp, and Allen Poma. "Purine Nucleoside Phosphorylase: Allosteric Regulation of a Dissociating Enzyme." In Advances in Experimental Medicine and Biology. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-7703-4_40.

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Snyder, Floyd F., Kuldeep Neote, Eddie Kwan, and Ellen R. Mably. "Synthesis and Turnover of Purine Nucleoside Phosphorylase in Human Lymphocytes." In Purine and Pyrimidine Metabolism in Man V. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-1248-2_40.

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Conference papers on the topic "Purine nucleoside phosphorylase. eng"

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Bulatovski, Aleksei, and Anatoliy Zinchenko. "Enzymatic synthesis of Favipiravir riboside using recombinant purine nucleoside phosphorylase." In National Scientific Symposium With International Participation: Modern Biotechnologies – Solutions to the Challenges of the Contemporary World. Institute of Microbiology and Biotechnology, Republic of Moldova, 2021. http://dx.doi.org/10.52757/imb21.075.

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Kierdaszuk, Borys, and Jacek Wierzchowski. "8-Azapurines as substrates for the E. coli purine nucleoside phosphorylase – II (xanthosine phosphorylase): Does the ribosylation always go to the aza-purine N(9)?" In XIIIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200507489.

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Tofovic, S. P., J. Hu, and E. Jackson. "Purine Nucleoside Phosphorylase Inhibition Attenuates the Metabolic Syndrome and Associated Pulmonary Hypertension and Right Ventricular Dysfunction." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4197.

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Reports on the topic "Purine nucleoside phosphorylase. eng"

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Aleksandrova, N. V., E. V. Benedickaya, I. Yu Alekhina, and A. V. Aleksandrov. ROLE OF ANTIBODIES TO PURINE NUCLEOSIDE PHOSPHORYLASE IN THE DIAGNOSIS OF INFECTIOUS DISEASES IN PATIENTS WITH RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS. Планета, 2018. http://dx.doi.org/10.18411/978-5-907109-24-7-2018-xxxv-23-27.

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