Relevant bibliographies by topics / Purine synthesis

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Purine synthesis'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Purine synthesis"

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Hasník, Zbyněk, Radek Pohl, Blanka Klepetářová, and Michal Hocek. "Synthesis of (purin-6-yl)acetates and their transformations to 6-(2-hydroxyethyl)- and 6-(carbamoylmethyl)purines." Collection of Czechoslovak Chemical Communications 74, no. 7-8 (2009): 1035–59. http://dx.doi.org/10.1135/cccc2009042.

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A novel approach to the synthesis of (purin-6-yl)acetates was developed based on Pd-catalyzed cross-coupling reactions of 6-chloropurines with a Reformatsky reagent. Their reduction with NaBH4 and treatment with MnO2 gave 6-(2-hydroxyethyl)purines, while reactions with amines in presence of NaCN afforded 6-(carbamoylmethyl)purines. Mesylation of the 6-(2-hydroxyethyl)purines followed by nucleophilic substitutions gave rise to several 6-(2-substituted ethyl)purines. This methodology was successfully applied to the synthesis of substituted purine bases and nucleosides for cytostatic and antivira
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Itakura, M., N. Maeda, and K. Yamashita. "Increased rate of purine biosynthesis in rat liver after bilateral adrenalectomy." American Journal of Physiology-Endocrinology and Metabolism 251, no. 4 (1986): E373—E378. http://dx.doi.org/10.1152/ajpendo.1986.251.4.e373.

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In bilaterally adrenalectomized rat liver the increased rate of de novo purine synthesis was shown by the increased [14C]glycine incorporation into hepatic acid-soluble purines with unchanged rapidly miscible glycine pool size and its turnover rate and by the increased rate of chasing of radiolabeled purines. At 24 h after adrenalectomy, the rate of de novo purine synthesis increased by 70%, 5-phosphoribosyl-1-pyrophosphate (PRPP) content increased by 200%, the specific activity of amidophosphoribosyltransferase (EC 2.4.2. 14; ATase) did not change, ATP and GTP showed a 33 and 24% decrease, an
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Allen, Shara, Julie L. Zilles, and Diana M. Downs. "Metabolic Flux in Both the Purine Mononucleotide and Histidine Biosynthetic Pathways Can Influence Synthesis of the Hydroxymethyl Pyrimidine Moiety of Thiamine in Salmonella enterica." Journal of Bacteriology 184, no. 22 (2002): 6130–37. http://dx.doi.org/10.1128/jb.184.22.6130-6137.2002.

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ABSTRACT Together, the biosyntheses of histidine, purines, and thiamine pyrophosphate (TPP) contain examples of convergent, divergent, and regulatory pathway integration. Mutations in two purine biosynthetic genes (purI and purH) affect TPP biosynthesis due to flux through the purine and histidine pathways. The molecular genetic characterization of purI mutants and their respective pseudorevertants resulted in the conclusion that <1% of the wild-type activity of the PurI enzyme was sufficient for thiamine but not for purine synthesis. The respective pseudorevertants were found to be informa
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Becker, Sidney, Jonas Feldmann, Stefan Wiedemann, et al. "Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides." Science 366, no. 6461 (2019): 76–82. http://dx.doi.org/10.1126/science.aax2747.

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Theories about the origin of life require chemical pathways that allow formation of life’s key building blocks under prebiotically plausible conditions. Complex molecules like RNA must have originated from small molecules whose reactivity was guided by physico-chemical processes. RNA is constructed from purine and pyrimidine nucleosides, both of which are required for accurate information transfer, and thus Darwinian evolution. Separate pathways to purines and pyrimidines have been reported, but their concurrent syntheses remain a challenge. We report the synthesis of the pyrimidine nucleoside
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Scott, Andrew, Weihua Zhou, Kari Wilder-Romans, et al. "DDRE-28. MECHANISTIC AND THERAPEUTIC LINKS BETWEEN PURINE BIOSYNTHESIS AND DNA DAMAGE IN GLIOBLASTOMA." Neuro-Oncology Advances 3, Supplement_1 (2021): i12. http://dx.doi.org/10.1093/noajnl/vdab024.050.

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Abstract Glioblastoma (GBM) is the most common and aggressive adult brain cancer. Radiation therapy (RT) is a critical treatment modality, and development of RT resistance is the predominant cause of recurrence and mortality in GBM patients. Using cell line models as well as patient-derived xenografts and neurospheres in orthotopic brain tumor models, we have identified increased rates and dependence upon de novo purine biosynthesis as a hallmark of GBM RT resistance. More recently, we have discovered that radiation treatment acutely stimulates flux through de novo purine synthesis in cell lin
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Tomlinson, Patricia Tolson, and Carol J. Lovatt. "Nucleotide Metabolism in ‘Washington’ Navel Orange Fruit: I. Pathways of Synthesis and Catabolism." Journal of the American Society for Horticultural Science 112, no. 3 (1987): 529–35. http://dx.doi.org/10.21273/jashs.112.3.529.

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Abstract The capacity of ‘Washington’ navel orange fruit [Citrus sinensis (L.) Osbeck] to synthesize and catabolize purines and pyrimidines was assessed. De novo biosynthesis of purine nucleotide was demonstrated by [14C] bicarbonate incorporation into purine nucleotides, blockage of this process by four known inhibitors, and assimilation of radiolabeled carbon from formate, both carbons of glycine, and carbon-3 of serine into the adenine ring. De novo synthesis of pyrimidines via the orotate pathway in young fruit was demonstrated by incorporation of [14C] bicarbonate and [6-14C]orotic acid i
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Rosiers, Christine Des, Stephan Nees, and Eckehart Gerlach. "Purine metabolism in cultured aortic and coronary endothelial cells." Biochemistry and Cell Biology 67, no. 1 (1989): 8–15. http://dx.doi.org/10.1139/o89-002.

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Purine salvage pathways in cultured endothelial cells of macrovascular (pig aorta) and microvascular (guinea pig coronary system) origin were investigated by measuring the incorporation of radioactive purine bases (adenine or hypoxanthine) or nucleosides (adenosine or inosine) into purine nucleotides. These precursors were used at initial extracellular concentrations of 0.1, 5, and 500 μM. In both types of endothelial cells, purine nucleotide synthesis occurred with all four substrates. Aortic endothelial cells salvaged adenine best among purines and nucleosides when applied at 0.1 μM. At 5 an
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Šilhár, Peter, Radek Pohl, Ivan Votruba, and Michal Hocek. "Synthesis of 2-Substituted 6-(Hydroxymethyl)purine Bases and Nucleosides." Collection of Czechoslovak Chemical Communications 70, no. 10 (2005): 1669–95. http://dx.doi.org/10.1135/cccc20051669.

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A facile and efficient methodology of the synthesis of 6-(hydroxymethyl)purine derivatives (bases and nucleosides) was developed based on Pd-catalyzed cross-coupling reactions of 6-halopurines or N-protected 2-amino-6-halopurines with (benzoyloxymethyl)zinc iodide followed by deprotection. Regioselective hydroxymethylations of 2,6-dihalopurines were also studied and used for the synthesis of 2-chloro-6-(hydroxymethyl)- or 2,6-bis(hydroxymethyl)purines. The 6-(hydroxymethyl)purine ribonucleoside 5f exerted high cytostatic effect and moderate inhibition of adenosine deaminase, while all the othe
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Vorotyntsev, S. I., A. I. Bilai, and I. M. Bilai. "Disorder of purine metabolism in the etiopathogenesis of urate nephrolithiasis." Current issues in pharmacy and medicine: science and practice 16, no. 1 (2023): 90–97. http://dx.doi.org/10.14739/2409-2932.2023.1.273835.

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Urinary stone disease (USD) is a polyetiological urological disease caused by both exogenous and endogenous factors, including hereditary ones. It is characterized by the appearance of stones in the kidneys and urinary tract, and a tendency to relapse, often with a severe course. Almost 25 % of stones consist of uric acid (UA). The leading role in the pathogenesis of urate nephrolithiasis (UN) is played by disorders of purine metabolism, which are characterized by the development of hyperuricemia (HU) and hyperuricuria. The aim of the work is to review modern literary sources on the role of pu
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Hocek, Michal, Hana Dvořáková, and Ivana Císařová. "Covalent Analogues of DNA Base-Pairs and Triplets V. Synthesis of Purine-Purine and Purine-Pyrimidine Conjugates Connected by Diverse Types of Acyclic Carbon Linkages." Collection of Czechoslovak Chemical Communications 67, no. 10 (2002): 1560–78. http://dx.doi.org/10.1135/cccc20021560.

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The title 1,2-bis(purin-6-yl)acetylenes, -diacetylenes, -ethylenes and -ethanes were prepared as covalent base-pair analogues starting from 6-ethynylpurines and 6-iodopurines by the Sonogashira cross-coupling or oxidative alkyne-dimerization reactions followed by hydrogenations. 6-[(1,3-Dimethyluracil-5-yl)ethynyl]purine (11) was prepared analogously and hydrogenated to the corresponding purine-pyrimidine conjugates linked via vinylene and ethylene linkers. Unlike the cytostatic bis(purin-6-yl)acetylenes and -diacetylenes, the purine-pyrimidine conjugates were inactive. Crystal structures of b
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Dissertations / Theses on the topic "Purine synthesis"

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Buckley, Ragan. "The purine world: experimental investigations into the prebiotic synthesis of purine nucleobases and intercalation of homopurine DNA duplexes." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/48971.

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Formamide is a solvent of great interest to prebiotic chemists because it is liquid over a wide range, it is less volatile than either water or HCN, and it possesses a versatile reactivity. When formamide is heated in the presence of minerals or inorganic catalysts, a variety of products including purine nucleobases are generated. Irradiation of formamide reaction solutions with ultraviolet light increases the yield and diversity of products, and eliminates the need for a mineral catalyst. We have also performed formamide reactions in the presence of pyrite, a mineral which is likely to have b
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Gumaste, V. K. "Synthesis reactions and analysis of substituted ureas and purine alkaloids." Thesis(M.Sc.), CSIR-National Chemical Laboratory, Pune, 1989. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2306.

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Humphries, Mark Jonathon. "Synthesis and chemistry of 5-aminoimidazole ribonucleosides." Thesis, Keele University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363753.

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Hagos, Asmerom M. "Tricyclic purine analogues as antiparasitic and antiviral agents." Diss., Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-03292004-141831/unrestricted/hagos%5Fasmerom%5Fm%5F200312%5Fphd.pdf.

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Anderson, Crystal Annette. "Reactivity of Re₂(CH₃COO)₂Cl₄·2H₂O with purine DNA dinucleotides." Scholarly Commons, 2005. https://scholarlycommons.pacific.edu/uop_etds/603.

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Covalent binding of dinuclear metal carboxylate compounds to purine DNA nucleobases has been shown to be a source of anticancer activity, and has resulted in intense research to understand the coordination of metal complexes to DNA. This investigation focuses on the formation of dirhenium metal:dinucleotide complexes of purine nucleobases. To our knowledge, complexes formed by the reaction of dinuclear rhenium metal compounds with dinucleotides have not been reported in the literature.
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Turner, David Michael. "Design and synthesis of purine isosteres as inhibitors of Nek2 and CDK2." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/1908.

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Nek2 and CDK2 are serine/threonine protein kinases that are implicated in cell cycle control and cancer. The Nek family of enzymes contains 11 known serine/threonine protein kinases (Nek1-11) and are involved in mitotic cell cycle control. There is evidence that of these 11 kinases, Nek2, Nek6, Nek7 and Nek9 play an important role in the regulation of mitotic events through microtubule control. Particular interest has been placed upon Nek2, which has been shown to have a critical role in mitosis, assisting centrosome disjunction. 6-Ethnyl purine 39, was identified as a submicromolar irreversib
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Grant, Sharon. "The design and synthesis of novel purine based inhibitors of cyclin-dependent kinases." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310023.

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LAMBERTUCCI, Catia. "Synthesis, Characterization, and Biological Activity of Purine and Pyrimidine Nucleoside and Nucleotide Analogues." Doctoral thesis, Università degli Studi di Camerino, 2008. http://hdl.handle.net/11581/401762.

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Purine and pyrimidine nucleosides and nucleotides are constituents of fundamental structures of the cells. In fact, they are constituents of nucleic acids and their structure is present in several coenzymes involved in cellular reduction/oxidation processes, like nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD). Furthermore ATP is the source of energy that drive the cellular metabolic reactions. 3'-5'-cyclicadenosinemonophosphate (cAMP) acts as second messenger controlling the activation of metabolic pathways. The biological relevance of these molecules is also due
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Zhong, Minghong. "N9 Alkylation and Glycosylation of Purines; A Practical Synthesis of 2-Chloro-2'-deoxyadenosine." Diss., CLICK HERE for online access, 2004. http://contentdm.lib.byu.edu/ETD/image/etd433.pdf.

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Frame, Andrew Scott. "The synthesis of some imidazole nucleosides as potential inhibitors of de novo purine nucleotide biosynthesis." Thesis, University of Lincoln, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386384.

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Books on the topic "Purine synthesis"

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Eastwood, P. R. Synthesis of new purine anti-viral and anti-cancer agents. UMIST, 1993.

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Zürich, Eidgenössische Technische Hochschule, ed. Synthese und Eigenschaften von Oligo-2'Desoxy-1',2'-Seco-D-Ribonukleotiden, Purin-Purin-gepaarte Oligonukleotide der Homo-DNA-Reihe. [s.n.], 1993.

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N.Y.) Barbara Mathes Gallery (New York. Purism and the spirit of synthesis: [exhibition] Barbara Mathes Gallery : April 19 through May 31, 1986. The Gallery, 1986.

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Bykov, Yuri, Roman Bekker, and Mikhail Grigoriev. PEPTIDOLOGY, PEPTIDOMICS AND PEPTIDE MEDICINE — HISTORY AND PERSPECTIVES. Publishing Center RIOR, 2024. http://dx.doi.org/10.29039/02144-6.

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The book is devoted to both history and modern theory and practice of medical and veterinary use of peptides, their isolation in pure form, their laboratory chemical synthesis, as well as history of the study of the properties of various peptide substances. First it were extracts or hydrolysates from animal tissues and organs. Later it were pure peptide hormones and mediators, cytokines, antibiotics, etc. The book is intended primarily for students who are in the process of getting higher medical education in the disciplines “General Medicine”, “Pediatrics”, “Pharmacy”, “Medical Biochemistry”,
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Blidstein, Moshe. The Origenist Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198791959.003.0009.

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This chapter argues that Origen’s purity discourse was innovative on many fronts, as can be seen in his writings on sexuality, baptism, and on dietary issues. Defilement imagery concerning sexuality is especially prominent. Although Origen did not prohibit marriage, he saw sexuality as defiled, the quintessential expression of human corporeality, closely connected with sin though not synonymous with it. I argue that Origen was the first Christian thinker who integrated the notion of temporary sexual defilement found in the Hebrew Bible with the second-century Christian notion of essential sexu
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Dalbeth, Nicola. Pathophysiology of gout. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0039.

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The clinical features of gout occur in response to monosodium urate (MSU) crystals. Gout should be considered a chronic disease of MSU crystal deposition. A number of pathophysiological checkpoints are required for development of gout. First, elevated urate concentrations are required: urate overproduction and underexcretion contribute to total urate balance. Overproduction occurs due to alterations in the purine synthesis and degradation pathways. Renal underexcretion is an important cause of elevated serum urate concentrations (hyperuricaemia), and occurs through alterations in the urate tra
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Allais, Lucy. Synthesis and Binding. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198724957.003.0002.

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There are a number of reasons to think that one of Kant’s concerns in the Critique of Pure Reason is with the active role the mind must play in organizing the sensory input to enable us to experience objects, and therefore that he thinks that something like what is now called perceptual binding is necessary for us to be presented with perceptual particulars. Given the centrality of the notion of synthesis in the Critique, as well as Kant’s claim that synthesis governed by the categories is needed for us to have what he calls ‘relation to an object’, it might be thought that Kant’s notion of sy
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Araújo, Ana Cláudia Vaz de. Síntese de nanopartículas de óxido de ferro e nanocompósitos com polianilina. Brazil Publishing, 2021. http://dx.doi.org/10.31012/978-65-5861-120-2.

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In this work magnetic Fe3O4 nanoparticles were synthesized through the precipitation method from an aqueous ferrous sulfate solution under ultrasound. A 23 factorial design in duplicate was carried out to determine the best synthesis conditions and to obtain the smallest crystallite sizes. Selected conditions were ultrasound frequency of 593 kHz for 40 min in 1.0 mol L-1 NaOH medium. Average crystallite sizes were of the order of 25 nm. The phase obtained was identified by X-ray diffractometry (XRD) as magnetite. Scanning electron microscopy (SEM) showed polydisperse particles with dimensions
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Segal, David. The Preparation of Materials. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198804079.003.0008.

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Chapter 8 covers aspects of materials preparation. It stresses that the availability of high-purity silicon was essential for the semiconductor industry as were high-purity thin films. Availability of critical materials is mentioned. Specific techniques that are mentioned include the polymerase chain reaction, ion implantation, chemical vapour deposition, plasma spraying and sol-gel processing. Polymer synthesis is also described.
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Klinkenborg, Thorsten. Untersuchungen zur Synthese neuartig [6,7]-überbrückter Purine durch Anellierungsreaktionen an 6-Hydrazinopurinen und Studien zur Darstellung neuer 8-substituierter 2 ́-Desoxyguanosine. 2002.

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Book chapters on the topic "Purine synthesis"

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Zalkin, Howard. "De Novo Purine Nucleotide Synthesis." In Bacillus subtilis and Other Gram-Positive Bacteria. ASM Press, 2014. http://dx.doi.org/10.1128/9781555818388.ch24.

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Boer, P., S. Brosh, and O. Sperling. "Hormone-induced stimulation of purine synthesis." In Fortschritte der Urologie und Nephrologie. Steinkopff, 1987. http://dx.doi.org/10.1007/978-3-642-72399-5_14.

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Tsutani, Hiroshi, Teruo Yoshimura, Michihiko Uchida, Kenichi Kamiya, Takanori Ueda, and Toru Nakamura. "Purine Nucleotide Synthesis during Terminal Differentiation." In Advances in Experimental Medicine and Biology. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5673-8_69.

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Page, Theodore, and Mary Coleman. "de Novo Purine Synthesis is Increased in the Fibroblasts of Purine Autism Patients." In Advances in Experimental Medicine and Biology. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5381-6_152.

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Moran, Richard G. "Folate antimetabolites inhibitory to de novo purine synthesis." In New Drugs, Concepts and Results in Cancer Chemotherapy. Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3876-9_4.

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Gordon, Ross B., and Bryan T. Emmerson. "Inhibition of De Novo Purine Synthesis by Methylthioadenosine." In Purine and Pyrimidine Metabolism in Man V. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-1248-2_102.

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Srivastava, Prem C., Roland K. Robins, and Rich B. Meyer. "Synthesis and Properties of Purine Nucleosides and Nucleotides." In Chemistry of Nucleosides and Nucleotides. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-0995-6_2.

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Marinello, Enrico, Maria Pizzichini, Anna Di Stefano, Lucia Terzuoli, and Roberto Pagani. "Purine Nucleotide Synthesis in Rat Liver after Castration." In Advances in Experimental Medicine and Biology. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-7703-4_84.

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Rowe, Peter B., Sandra E. McEwen, and Annette Kalaizis. "Purine Nucleotide Synthesis in Cultured Rat Embryos Undergoing Organogenesis." In Purine and Pyrimidine Metabolism in Man V. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-1248-2_84.

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Snyder, Floyd F., Kuldeep Neote, Eddie Kwan, and Ellen R. Mably. "Synthesis and Turnover of Purine Nucleoside Phosphorylase in Human Lymphocytes." In Purine and Pyrimidine Metabolism in Man V. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-1248-2_40.

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Conference papers on the topic "Purine synthesis"

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Alekseev, Georgii A., and Vladimir E. Martirosov. "Synchronous Synthesis of Microwave Modulated Signal: Spectrum Purity Control & Analysis." In 2025 7th International Youth Conference on Radio Electronics, Electrical and Power Engineering (REEPE). IEEE, 2025. https://doi.org/10.1109/reepe63962.2025.10971018.

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Gonz�lez-Cazorla, Franc, Jordi Pujol, Oriol Mart�nez, Lluis Soler, and Mois�s Graells. "Assessing the economic viability of green methanol production: The critical role of CO2 purity in green methanol production." In The 35th European Symposium on Computer Aided Process Engineering. PSE Press, 2025. https://doi.org/10.69997/sct.149306.

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The growing concern over climate change and rising carbon dioxide (CO2) emissions have spurred the development of strategies to upcycle greenhouse gases. One promising solution is the synthesis of green methanol via catalytic hydrogenation of captured CO2 using renewable hydrogen (H2). This provides a versatile chemical feedstock for fuels and industrial processes while reducing CO2 levels. Recent advancements in CO2 capture technologies achieve purities ranging from 83% to 98% (v/v), enabling a sustainable integration with green hydrogen for methanol production. While research has largely foc
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Hsu, Tzu-Hao, Chi-Hsien Chang, and Tian-Li Yu. "Program Synthesis on Single-Layer Loop Behavior in Pure Functional Programming." In 2024 IEEE Congress on Evolutionary Computation (CEC). IEEE, 2024. http://dx.doi.org/10.1109/cec60901.2024.10612128.

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Bulatovski, Aleksei, and Anatoliy Zinchenko. "Enzymatic synthesis of Favipiravir riboside using recombinant purine nucleoside phosphorylase." In National Scientific Symposium With International Participation: Modern Biotechnologies – Solutions to the Challenges of the Contemporary World. Institute of Microbiology and Biotechnology, Republic of Moldova, 2021. http://dx.doi.org/10.52757/imb21.075.

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Erez, Ayelet, Eytan Ruppin, Rom Keshet, and Joo Sang Lee. "Abstract IA21: Blocking purine synthesis in cancer promotes response to immunotherapy." In Abstracts: AACR Special Conference on the Advances in Pediatric Cancer Research; September 17-20, 2019; Montreal, QC, Canada. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.pedca19-ia21.

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Maria, Catarina, João Barros, Nuno Xavier, et al. "Synthesis of New Purine Nucleosides as potential Metal Chelators and Anticholinesterase Agents." In International Electronic Conference on Medicinal Chemistry. MDPI, 2022. http://dx.doi.org/10.3390/ecmc2022-13451.

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Daineko, A. V., A. B. Bulatovski, and A. I. Zinchenko. "STUDY ON POTENTIAL ENGINEERING OF ESCHERICHIA COLI XANTHOSE PHOSPHORYLASE STRAIN-PRODUCER." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2021. http://dx.doi.org/10.46646/sakh-2021-2-38-41.

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Genetic engineering is an actively developing branch of modern biotechnology. Using the methods of genetic engineering, it is possible to construct new forms of microorganisms that can synthesize a variety of substances, including enzymes. Xanthosine phosphorylase is the second purine nucleoside phosphorylase (PNP-II) in E. coli. This enzyme performs both reactions of phosphorolysis and the synthesis of purine deoxy / ribonucleosides. Due to this ability, xanthosine phosphorylase can catalyze the reaction of the formation of nicotinamide riboside. This substance is a precursor of the most impo
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Novosjolova, Irina, Ērika Bizdēna, and Māris Turks. "Derivatives of 2,6-diazidopurine and 2,6-bis-(1,2,3-triazol-1-yl) purine as useful intermediates in the synthesis of modified purine nucleosides." In XVIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2014. http://dx.doi.org/10.1135/css201414332.

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Hocek, Michal, and Dana Hocková. "Regioselective cross-coupling reactions in the synthesis of multisubstituted purine bases and nucleosides." In XIIIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200507213.

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Birichevskaya, L. L., M. A. Vinter, A. A. Doroshevich, M. А. Khancheuski, E. I. Kvasyuk, and A. I. Zinchenko. "SYNTHESIS OF THE MODIFIED NUCLEOSIDE 8-BROMADENOSINE AND ITS PHOSPHOLIPID DERIVATIVE." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2021. http://dx.doi.org/10.46646/sakh-2021-2-20-23.

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Modified nucleoside 8-bromoadenosine possessing high reactive capacity may serve as a basic compound for the synthesis of a large number of purine antimetabolites showing potentially therapeutic activities toward several tumor and viral diseases. In this study, 8-bromoadenosine was produced by a simple eco-friendly procedure following the treatment of nucleoside precursor adenosine with aqueous bromine solution. In the course of enzymatic transphosphatidylation reaction, the first synthesis of phospholipid derivative of the above-mentioned nucleoside -5‘-(1,2-dimyristoyl phosphatidyl)-8-bromoa
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Reports on the topic "Purine synthesis"

1

Pagoria, P. F. Synthesis of pure RDX. Office of Scientific and Technical Information (OSTI), 1994. http://dx.doi.org/10.2172/10162021.

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Boecker, W., B. Mehosky, R. Rogers, R. Storm, and V. Venkateswaran. Synthesis of high purity sinterable silicon carbide powder. Office of Scientific and Technical Information (OSTI), 1989. http://dx.doi.org/10.2172/6974913.

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Greenberg, Shafrira, A. B. Lever, and Clifford C. Leznoff. Approaches Towards the Synthesis of a 2,9,16,23-Tetrasubstitutedphthalocyanine as a Pure Isomer. Defense Technical Information Center, 1988. http://dx.doi.org/10.21236/ada197366.

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National Energy Technology Laboratory. Application of a Barrier Filter at a High Purity Synthetic Graphite Plant, CRADA 99-F035, Final Report. Office of Scientific and Technical Information (OSTI), 2000. http://dx.doi.org/10.2172/784298.

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Bessen, Nathan, Diana Stamberga, and Bruce Moyer. Synthesis and Purity Specifications for N,N'-Dicyclohexyl-N"-(10-nonadecyl)guanidinium Chloride for Use in Next Generation Caustic-Side Solvent Extraction. Office of Scientific and Technical Information (OSTI), 2022. http://dx.doi.org/10.2172/1869073.

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Sukenik, Assaf, Paul Roessler, and John Ohlrogge. Biochemical and Physiological Regulation of Lipid Synthesis in Unicellular Algae with Special Emphasis on W-3 Very Long Chain Lipids. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7604932.bard.

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Various unicellular algae produce omega-3 (w3) very-long-chain polyunsaturated fatty acids (VLC-PUFA), which are rarely found in higher plants. In this research and other studies from our laboratories, it has been demonstrated that the marine unicellular alga Nannochloropsis (Eustigmatophyceae) can be used as a reliable and high quality source for the w3 VLC-PUFA eicosapentaenoic acid (EPA). This alga is widely used in mariculture systems as the primary component of the artificial food chain in fish larvae production, mainly due to its high EPA content. Furthermore, w3 fatty acids are essentia
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Busch, Ella, and Jacob Ware. The Weaponization of Deepfakes: Digital Deception on the Far-Right. ICCT, 2023. http://dx.doi.org/10.19165/2023.2.07.

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In an ever-evolving technological landscape, digital disinformation is on the rise, as are its political consequences. In this paper, we explore the creation and distribution of synthetic media by malign actors, specifically a form of artificial intelligence-machine learning (AI/ML) known as the deepfake. Individuals looking to incite political violence are increasingly turning to deepfakes–specifically deepfake video content–in order to create unrest, undermine trust in democratic institutions and authority figures, and elevate polarised political agendas. We present a new subset of individua
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Altstein, Miriam, and Ronald Nachman. Rationally designed insect neuropeptide agonists and antagonists: application for the characterization of the pyrokinin/Pban mechanisms of action in insects. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7587235.bard.

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The general objective of this BARD project focused on rationally designed insect neuropeptide (NP) agonists and antagonists, their application for the characterization of the mechanisms of action of the pyrokinin/PBAN (PK-PBAN) family and the development of biostable, bioavailable versions that can provide the basis for development of novel, environmentally-friendly pest insect control agents. The specific objectives of the study, as originally proposed, were to: (i) Test stimulatory potencies of rationally designed backbone cyclic (BBC) peptides on pheromonotropic, melanotropic, myotropic and
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Regulated Products Risk Assessment Team. Safety assessment: Synthetic Cannabidiol (CBD) as a novel food for use in food supplements. Food Standards Agency, 2024. http://dx.doi.org/10.46756/sci.fsa.fei457.

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An application was submitted to the Food Standards Agency (FSA) and Food Standards Scotland (FSS) in January 2021 from Chanelle McCoy CBD Ltd (“the applicant”) for the authorisation of synthetic cannabidiol (CBD) as a novel food. The novel food is a synthetic >98% pure form CBD which is intended to be used as food supplements for adults. For CBD a provisional Acceptable Daily Intake (ADI) of 10 mg/day has been published by the FSA and was considered in assessing this novel food. The provisional ADI (section 2.7) was recommended, subject to the existing advice to consumers that pregnant and
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Yaron, Zvi, Abigail Elizur, Martin Schreibman, and Yonathan Zohar. Advancing Puberty in the Black Carp (Mylopharyngodon piceus) and the Striped Bass (Morone saxatilis). United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7695841.bard.

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Both the genes and cDNA sequences encoding the b-subunits of black carp LH and FSH were isolated, cloned and sequenced. Sequence analysis of the bcFSHb and LHb5'flanking regions revealed that the promoter region of both genes contains canonical TATA sequences, 30 bp and 17 bp upstream of the transcription start site of FSHb and LHb genes, respectively. In addition, they include several sequences of cis-acting motifs, required for inducible and tissue-specific transcriptional regulation: the gonadotropin-specific element (GSE), GnRH responsive element (GRE), half sites of estrogen and androgen
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