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Journal articles on the topic 'Purity of Heart'
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1
Munzer, Stephen R. "Kierkegaard on Purity of Heart." International Philosophical Quarterly 56, no. 3 (2016): 315–36. http://dx.doi.org/10.5840/ipq201661466.
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Hart, James G. "Axiology as the Form of Purity of Heart." Philosophy Today 34, no. 3 (1990): 206–21. http://dx.doi.org/10.5840/philtoday199034311.
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Tucker, Travis. "Kierkegaard's Purity of Heart and the “Sunday-Monday Gap”." Theology Today 67, no. 1 (April 2010): 24–35. http://dx.doi.org/10.1177/004057361006700104.
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Basir, Amir, Philip de Groot, Paul F. Gründeman, Claudia Tersteeg, Coen Maas, Arjan Barendrecht, Joost Van Herwaarden, et al. "In Vitro Hemocompatibility Testing of Dyneema Purity Fibers in Blood Contact." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 10, no. 3 (May 2015): 195–201. http://dx.doi.org/10.1097/imi.0000000000000163.
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Objective Heart valve and vascular prosthesis implantation is a common procedure for patients with heart valve stenosis or regurgitation and dilated or obstructive vascular disease. Drawbacks of conventional valve prostheses are the requirement for anticoagulant drugs, moderate durability, and suboptimal resistance to fatigue and tear. Dyneema Purity fibers are made from ultra-high-molecular-weight polyethylene filaments and are very thin, flexible, and fatigue and abrasion resistant and have high strength. Therefore, prostheses made from Dyneema Purity fibers might be attractive for use in the minimally invasive treatment of valvular- and vascular diseases. The aim of this study was to test the hemocompatibility of Dyneema Purity fibers in contact with blood. Methods Real-time platelet adhesion in human blood of 3 volunteers was quantified after 5 minutes of perfusion on single filaments (Ø 15 μm) of Dyneema Purity and polyester fibers. Plasma thrombin generation was measured by fluoroscopy for patches of Dyneema Purity fibers and for 5 commonly used polyester and expanded polytetrafluoroethylene cardiovascular prostheses. Results Platelet adhesion per 1 mm was 6 ± 1.4 on Dyneema Purity filaments and 15 ± 3.4 on polyester filaments ( P = 0.02). Total formed thrombin and the time to peak of its maximum were noninferior for patches of Dyneema Purity fibers compared with the reference materials. Conclusions Dyneema Purity fibers are noninferior in adhesion and coagulation activation compared with commonly used cardiovascular prostheses.
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Rotberg, Robert I. "The Swedenborgian Search for African Purity." Journal of Interdisciplinary History 36, no. 2 (October 2005): 233–40. http://dx.doi.org/10.1162/0022195054741677.
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Emanuel Swedenborg, an engineer and mystic of the Enlightenment, prophesied that mankind's spiritual perfection was to be found deep in the heart of Africa. That idea unleashed a flurry of scientific and geographical inquiry among his disciples and other Swedes that has long been neglected. In addition to stimulating an era of romantic colonization in Africa, some of the activity and enthusiasm of the Swedenborgians contributed significantly to the abolitionist agitation that eventually ended the slave trade.
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Absillis, Kevin, and Jürgen Jaspers. "Beware of the weeds." International Journal of the Sociology of Language 2016, no. 242 (January 1, 2016): 1–24. http://dx.doi.org/10.1515/ijsl-2016-0031.
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AbstractResearch into linguistic purism often reflects a critical, if not contemptuous attitude towards its subject of inquiry. The reasons for this are purists’ prescriptivist stance, as well as their frequent association with ethno-linguistic nationalism, an ideology in moral disrepute. We argue that this approach of purism produces blind spots. Following Pratt’s suggestion, we reconsider linguistic purism in this article as the effect of a utopian discourse and show how a desire for (linguistic) purity is at the very heart of the project of modernity. We apply our theoretical framework to the history of purism in modern Flanders (nineteenth to twenty-first century).
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Achar, Pramod N., and David Treumann. "Purity and decomposition theorems for staggered sheaves." Journal of the Institute of Mathematics of Jussieu 11, no. 4 (April 2, 2012): 695–745. http://dx.doi.org/10.1017/s1474748011000211.
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AbstractTwo major results in the theory of ℓ-adic mixed constructible sheaves are the purity theorem (every simple perverse sheaf is pure) and the decomposition theorem (every pure object in the derived category is a direct sum of shifts of simple perverse sheaves). In this paper, we prove analogues of these results for coherent sheaves. Specifically, we work with staggered sheaves, which form the heart of a certain t-structure on the derived category of equivariant coherent sheaves. We prove, under some reasonable hypotheses, that every simple staggered sheaf is pure, and that every pure complex of coherent sheaves is a direct sum of shifts of simple staggered sheaves.
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Zaloom, Caitlin. "Mary Douglas, Purity and Danger (1966)." Public Culture 32, no. 2 (May 1, 2020): 415–22. http://dx.doi.org/10.1215/08992363-8090159.
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Mary Douglas’s masterpiece Purity and Danger holds a troubled place in the social sciences and humanities. Both classic and cast out, the book’s analysis cannot be ignored. In fact, Douglas’s thesis, “Dirt is matter out of place,” can help explain the fate of the very book that made it famous. Purity and Danger presents a probing cultural analysis. Douglas argued that social systems should be understood by what they expel but also that the true power of dirt lies in the acts of cleansing. Cultural upheaval, decolonization, and war together appeared to render Douglas’s interest in social stability naive, however, and Purity and Danger languished following its publication in 1966. Today’s politics of purity, from white nationalism to rule by imprisonment, makes Purity and Danger more necessary than ever. The tension between the search for human universals and the social and historical particularism at its heart continues to haunt social inquiry today.
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Timbie, Janet. "Purity of Heart in Early Ascetic and Monastic Literature (review)." Journal of Early Christian Studies 8, no. 1 (2000): 114–15. http://dx.doi.org/10.1353/earl.2000.0019.
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Morgan, Jeffrey. "Guilt, Self-Awareness, and the Good Will in Kierkegaard’s Confessional Discourses." Studies in Christian Ethics 33, no. 3 (January 9, 2019): 352–70. http://dx.doi.org/10.1177/0953946818822277.
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The specific aim of this article is to focus on Kierkegaard’s confessional discourses and to examine his appreciation for the experience of guilt—the feeling of guilt and the acknowledgment of guilt—in a person’s efforts to act with a good will, or what he calls ‘purity of heart’. The article offers an interpretation of what Kierkegaard means by the ‘purity of heart’ that guilt serves, and it makes an argument that in this service to ‘purity of heart’ the relationship between guilt and self-awareness is especially significant. For Kierkegaard, without the subjective feeling of guilt and without a self-reflective endorsement of that feeling, a person cannot overcome a bad or divided will; a person who strives to have a good will is a person who is able rightly to acknowledge, appropriate or endorse his or her guilt. Furthermore, Kierkegaard’s claim is not simply that this acknowledgment of guilt is a necessary precondition for a good will but that it is itself a quintessential action of a good will. The article concludes with a note of caution that while Kierkegaard does not want to make guilt a final word about a person, a word that overshadows grace and pardon, he is also very wary of the ways people fail to take their own guilt seriously and thereby forfeit the benefits of its self-disclosing power.
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Grafe, M., W. Auch-Schwelk, K. Graf, D. Terbeek, H. Hertel, M. Unkelbach, A. Hildebrandt, and E. Fleck. "Isolation and characterization of macrovascular and microvascular endothelial cells from human hearts." American Journal of Physiology-Heart and Circulatory Physiology 267, no. 6 (December 1, 1994): H2138—H2148. http://dx.doi.org/10.1152/ajpheart.1994.267.6.h2138.
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In vivo models to investigate mechanisms of local hemostasis in the macro- and microvascular coronary circulation are not available. Therefore, we established a culture system of human macro- and microvascular endothelial cells with high cellular yield and high endothelial cell purity. Microvascular endothelial cells from human hearts were isolated by enzymatic treatment of cardiac muscle preparations obtained during heart transplantation. The isolated microvessels were used to start cultures that were subsequently separated and purified from contaminating nonendothelial cells by paramagnetic beads linked to the lectin Ulex europaeus agglutinin I. Macrovascular endothelial cells were isolated from epicardial coronary arteries and purified by paramagnetic beads as well. With this method high purity (< 2% nonendothelial cells) was achieved as judged from fluorescence-activated cell sorting. Immunochemistry demonstrated the expression of several typical endothelial markers. The two endothelial cell types displayed functional heterogeneity in respect to bradykinin degradation and plasminogen activator inhibitor-1 activity. Thus the ability to selectively isolate and culture human macro- and microvascular cardiac endothelial cells provides a valuable tool to systematically investigate endothelial function in human hearts.
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Zenin, Kirill V. "ON CATEGORIES OF NEED AND PURITY OF HEART IN WORKS BY S. KIERKEGAARD." RSUH/RGGU Bulletin. Series Philosophy. Social Studies. Art Studies, no. 1 (2017): 9–20. http://dx.doi.org/10.28995/2073-6401-2017-1-9-20.
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van Wolde, Ellen. "A Prayer for Purification." Vetus Testamentum 70, no. 2 (August 28, 2019): 340–60. http://dx.doi.org/10.1163/15685330-12341388.
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Abstract This article focuses on the pivotal role of verses 12-14 in Psalm 51. In v. 13 the speaker expresses the fear that due to his transgressions God’s spirit of holiness will be taken away, because God does not tolerate impurity of any kind. For the impurity generated by the transgressions will be projected onto the sanctuary, which in this way will be defiled. Therefore, aligned with רוח קדשך in v. 13 is טהור לב in v. 12: purity is the sine qua non for God’s holy spirit to stay and keep active in the midst of the Israelites. In this view, the impure world of words and deeds is the total from which the pure ones are to be separated. It is not the purity of the heart itself, but the process of purification that is expressed here, so that the pure heart remains, cleared of sins.
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Carlisle, Clare. "Living in the Light of Religious Ideals." Royal Institute of Philosophy Supplement 68 (June 20, 2011): 245–55. http://dx.doi.org/10.1017/s1358246111000026.
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As a ‘poet of the religious’, Søren Kierkegaard sets before his reader a constellation of spiritual ideals, exquisitely painted with words and images that evoke their luminous beauty. Among these poetic icons are ideals of purity of heart; love of the neighbour; radiant self-transparency; truthfulness to oneself, to another person, or to God. Such ideals are what the ‘restless heart’ desires, and in invoking them Kierkegaard refuses to compromise on their purity – while insisting also that they are impossible to attain. It is the human condition which makes them impossible, and he is willing to describe this in dogmatic terms as original sin – sin being the refusal and loss of God, and thus also the loss of a self that has its ontological ground in its relationship to God – but he is more concerned to explore it in psychological terms. The human condition is for Kierkegaard characterised not merely by ignorance, but by wilful self-deception.
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Burton-Christie, Douglas. "The Call of the Desert: Purity of Heart and Power in Early Christian Monasticism." Pro Ecclesia: A Journal of Catholic and Evangelical Theology 7, no. 2 (May 1998): 216–34. http://dx.doi.org/10.1177/106385129800700208.
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Ferrari, Luca, and Stefan G. D. Rüdiger. "Recombinant production and purification of the human protein Tau." Protein Engineering, Design and Selection 31, no. 12 (December 1, 2018): 447–55. http://dx.doi.org/10.1093/protein/gzz010.
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Abstract Tau protein is a microtubule-stabilising protein whose aggregation is linked to Alzheimer’s Disease and other forms of dementia. Tau biology is at the heart of cytoskeletal dynamics and neurodegenerative mechanisms, making it a crucial protein to study. Tau purification, however, is challenging as Tau is disordered, which makes it difficult to produce in recombinant system and is degradation-prone. It is thus challenging to obtain pure and stable preparations of Tau. Here, we present a fast and robust protocol to purify Tau recombinantly in Escherichia coli. Our protocol allows purifying Tau either tag-less or FLAG-tagged at its N-terminus, and Tau fragments of interest. By exploiting a cleavable affinity tag and two anion exchange columns, we obtained Tau preparations of high purity, stable and suitable for in vitro studies, including aggregation experiments that resemble neurodegenerative processes.
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Irina Bryndina, Evgeniy Bryndin*,. "Hygiene and Endoecology, Light Bioenergy and Natural Ecology, Balanced Mentality and Spiritual Life as Criterion of Health." Innovative Journal of Medical and Health Science 9, no. 2 (February 28, 2019): 299–306. http://dx.doi.org/10.15520/ijmhs.v9i2.2459.
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Despite many attempts to measure health, it wasn’t offered any scale which wouldhave practical value in this plan. Absence of the uniform point of view on a problemof essence of health is obvious. A specification of essence of health – the mainmethodological problem of the doctrine about health. In article health is allocatedin independent medico-social category which is characterized by direct indicators. Inmedical community various approaches to a concept health were created: hygienic,adaptive, genetic, donozological, safe, equilibrium, physiological, on health, viable,self-regulating, endoecological, resonant, spiritual, naturalistic and the combined approaches.We will consider spiritually - naturalistic approach to a concept health.Approach is based on processes of the nature and a spiritual entity of the person. TheWorld Health Organization considers that health of the person for 75% his conductof life and a power supply system, for 10% - heredity determines, another 10% - environmentalconditions, and only for 5% of service of health care. Health of the personmost of all depends on a conduct of life. Natural and spiritual processes and a healthylifestyle help the person and society to be healthy. Purity of the person is guarantee ofhis health. Spiritual and also mental (sincere), power, physiological and anatomic purityis criterion of health of each person. The hygiene maintains anatomic health. Theendoecology maintains physiological health. The natural ecology and physical cultureprovides power purity. The orthodox psychology helps to provide mental purity. Spirituallife provides spiritual purity. The hygiene and endoecology, physical culture andnatural ecology, balanced mentality (quiet mind and quiet heart) and spiritual life area healthy lifestyle. The healthy lifestyle maintains purity and a healthy condition ofthe person.
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Kiselev, Mikhail S. "The concept of “heart” in Old Irish church literature: The case of the Apgitir chrábaid." Izvestiya of Saratov University. New Series. Series: Philosophy. Psychology. Pedagogy 21, no. 1 (March 24, 2021): 14–18. http://dx.doi.org/10.18500/1819-7671-2021-21-1-14-18.
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This paper attempts to analyze the instances and contexts of the use of the concept “heart”, which is the key concept for Christian anthropology, based on the material of Old Irish church literature, namely, on the treatise Apgitir chrábaid. The following cases of using the word “heart” in the studied text are revealed: “love for God in the heart”, “fear of God in the heart”, “purity of the heart”, “simplicity of the heart”, “confession of something in the heart”, “heart as a container of faith” , “heart as the dwelling place of God”, “heart as the place where the Truth is”. These cases are grouped by the author into types. It was done so in order to review them within the conceptual grid, built by various researchers, who utilized the idea of different semantic base for each case of the “heart” usage in Christian literature of Early Middle Ages. “Heart” usage groups were formed as 1) a physical organ 2) the emotion center 3) the intelligence center 4) the center of willpower and desires 5) the center of spiritual life and religious experience 6) the symbolic core of a human being, the synonym of a human being in general, spirit or soul in particular. An assumption is made about the presence of an intertextual connection between some fragments of the Apgitir chrábaid where the concept of “heart” is present and a number of biblical texts (Gospel of John, Epistle to the Ephesians, The Second Epistle of Peter).
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Stettler, C. "Purity of Heart in Jesus' Teaching: Mark 7:14-23 Par. as an Expression of Jesus' Basileia Ethics." Journal of Theological Studies 55, no. 2 (October 1, 2004): 467–502. http://dx.doi.org/10.1093/jts/55.2.467.
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Richardson, Philip. "What are the Spiritual Sacrifices of 1 Peter 2:5? Some Light from Philo of Alexandria." Evangelical Quarterly 87, no. 1 (April 26, 2015): 3–17. http://dx.doi.org/10.1163/27725472-08701001.
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Peter’s reference to ‘spiritual sacrifices’ in 1 Pet. 2:5 is unspecified and scholars have proposed a variety of possible solutions to identify their referent. In this paper, we shed light on this question by considering how the term may have been heard by the readers in their historical context. Most scholars consider the audience to be majority Gentile and clearly in a diaspora setting (1 Pet. 1:1). Philo, as a Hellenistic Jewish author writing to the diaspora, has much to say about spiritual sacrifices, connecting them with the rational soul of virtue, which is purified from the passions and issues in virtuous conduct. Returning to 1 Peter, we observe the wider context of 1 Pet. 2:5 emphasizes purity of heart and soul, a disciplined mind and a self-controlled avoidance of passion, which also issues in virtuous conduct. This framework would have helped the original readers to identify the spiritual sacrifices.
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Rizvi, Sajjad H. "Epistles of the Brethren of Purity. On Arithmetic and geometry." American Journal of Islam and Society 31, no. 1 (January 1, 2014): 116–20. http://dx.doi.org/10.35632/ajis.v31i1.1027.
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The significance of the epistles on a range of intellectual disciplines by thegroup of scholars known as the Brethren of Purity (Ikhwan al-Safa’) has beenknown for some time, although one might argue that their significance for aproper assessment of Islamic intellectual history has been neglected. The116 The American Journal of Islamic Social Sciences 31:1book under review is part of an exciting new project initiated by the Instituteof Ismaili Studies in London to re-edit the whole text with critical analyticaltranslations and annotations undertaken by a number of specialists aroundthe world. For those of us who specialize in Islamic intellectual history andneed texts to use in the classroom, this is an excellent and most welcome development.The companion volume edited by el-Bizri, which attempts notonly to make sense of who the Ikhwan were but also to assess their impact,demonstrates that their significance was recognized by later traditions evenwhen it was occluded. One small quibble – it would have been good to seethe Arabic and English on facing pages, which may have been logisticallyproblematic. As it is, it makes the comparison of the original text with theEnglish a bit more difficult.The two epistles translated here are the first in the sequence and constitutepart of the first section of the Rasā’il on the mathematical and propaedeuticalsciences (al-‘ulūm al-riyādīyah al-ta‘līmīyah). Nader el-Bizri, thetranslator and editor of the series, is a historian of philosophy and science inthe Islamic world and has recently been focusing on the history of geometry,mathematics, and optics and publishing widely on Ibn al-Haytham (d. 1040).These two epistles form part of the ancient quadrivium that constituted amore advanced stage of study associated with Boethius (d. 524) and wasbased upon the mathematics of Nicomachus of Gerasa, a Neopythagoreanof the first century CE: training in arithmetic, geometry, music, and astronomywere considered to be the very heart of a scientific education. After the firsttwo epistles, epistle 3 deals with astronomy, epistle 4 with cosmography,epistle 5 with music, and epistle 6 with proportions (that ties the quadriviumtogether) – and that is before they move onto the next set of propaeduetics,namely the logical organon beginning with epistles 7 and 8 (the theoreticaland practical arts) that provide a classification of the sciences on which theapproach to holism is based ...
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STOOPS, JAMIE. "CLASS AND GENDER DYNAMICS OF THE PORNOGRAPHY TRADE IN LATE NINETEENTH-CENTURY BRITAIN." Historical Journal 58, no. 1 (February 9, 2015): 137–56. http://dx.doi.org/10.1017/s0018246x14000090.
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ABSTRACTDuring the second half of the nineteenth century, British social purity campaigners framed the pornography trade as a major source of cultural and moral pollution. As in their anti-prostitution efforts, purity campaigners presented the abolition of pornography as an attempt to protect women, children, and impressionable members of the lower classes from sexual immorality. Their rhetoric and policy efforts, however, reveal deeply entrenched fears of middle-class vulnerability to the negative effects of pornographic literature and images. Building on existing obscenity studies scholarship, this article explores the role of class and gender tension in nineteenth-century pornography regulation. In contrast to the majority of work on Victorian pornography, this article focuses on the British lower classes as producers and distributors rather than consumers of pornography. In addition, this article argues for a higher level of female participation in the pornography trade than has been previously recognized. By focusing on the contradictions and biases at the heart of campaigns against pornography, this article explores the ways in which regulation efforts and discourses of obscenity were shaped by the class and gender dynamics of the pornography trade.
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Belotti, Daniela, Giuseppe Gaipa, Beatrice Bassetti, Benedetta Cabiati, Gabriella Spaltro, Ettore Biagi, Matteo Parma, et al. "Full GMP-Compliant Validation of Bone Marrow-Derived Human CD133+Cells as Advanced Therapy Medicinal Product for Refractory Ischemic Cardiomyopathy." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/473159.
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According to the European Medicine Agency (EMA) regulatory frameworks, Advanced Therapy Medicinal Products (ATMP) represent a new category of drugs in which the active ingredient consists of cells, genes, or tissues. ATMP-CD133 has been widely investigated in controlled clinical trials for cardiovascular diseases, making CD133+cells one of the most well characterized cell-derived drugs in this field. To ensure high quality and safety standards for clinical use, the manufacturing process must be accomplished in certified facilities following standard operative procedures (SOPs). In the present work, we report the fully compliant GMP-grade production of ATMP-CD133 which aims to address the treatment of chronic refractory ischemic heart failure. Starting from bone marrow (BM), ATMP-CD133 manufacturing output yielded a median of 6.66 × 106of CD133+cells (range 2.85 × 106–30.84 × 106), with a viability ranged between 96,03% and 99,97% (median 99,87%) and a median purity of CD133+cells of 90,60% (range 81,40%–96,20%). Based on these results we defined our final release criteria for ATMP-CD133: purity ≥ 70%, viability ≥ 80%, cellularity between 1 and 12 × 106cells, sterile, and endotoxin-free. The abovementioned criteria are currently applied in our Phase I clinical trial (RECARDIO Trial).
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Soergel, Wolfgang, and Matthias Wendt. "PERVERSE MOTIVES AND GRADED DERIVED CATEGORY." Journal of the Institute of Mathematics of Jussieu 17, no. 2 (February 26, 2016): 347–95. http://dx.doi.org/10.1017/s1474748016000013.
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For a variety with a Whitney stratification by affine spaces, we study categories of motivic sheaves which are constant mixed Tate along the strata. We are particularly interested in those cases where the category of mixed Tate motives over a point is equivalent to the category of finite-dimensional bigraded vector spaces. Examples of such situations include rational motives on varieties over finite fields and modules over the spectrum representing the semisimplification of de Rham cohomology for varieties over the complex numbers. We show that our categories of stratified mixed Tate motives have a natural weight structure. Under an additional assumption of pointwise purity for objects of the heart, tilting gives an equivalence between stratified mixed Tate sheaves and the bounded homotopy category of the heart of the weight structure. Specializing to the case of flag varieties, we find natural geometric interpretations of graded category ${\mathcal{O}}$ and Koszul duality.
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Lee, Claire, Jia Zang, James Cuff, Neil McGachy, Theresa K. Natishan, Christopher J. Welch, Roy Helmy, and Frank Bernardoni. "Application of Heart-Cutting 2D-LC for the Determination of Peak Purity for a Chiral Pharmaceutical Compound by HPLC." Chromatographia 76, no. 1-2 (December 20, 2012): 5–11. http://dx.doi.org/10.1007/s10337-012-2367-5.
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Li, Xuena, Yafu Yin, Bulin Du, Na Li, and Yaming Li. "The Synthesis and Evaluations of the68Ga-Lissamine Rhodamine B (LRB) as a New Radiotracer for Imaging Tumors by Positron Emission Tomography." BioMed Research International 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/8549635.
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Purpose. The aim of this study is to synthesize and evaluate68Ga-labeled Lissamine Rhodamine B (LRB) as a new radiotracer for imaging MDA-MB-231 and MCF-7 cells induced tumor mice by positron emission tomography (PET).Methods. Firstly, we performed the radio synthesis and microPET imaging of68Ga(DOTA-LRB) in athymic nude mice bearing MDA-MB-231 and MCF-7 human breast cancer xenografts. Additionally, the evaluations of18F-fluorodeoxyglucose (FDG), as a glucose metabolism radiotracer for imaging tumors in the same xenografts, have been conducted as a comparison.Results. The radiochemical purity of68Ga(DOTA-LRB) was >95%. MicroPET dynamic imaging revealed that the uptake of68Ga(DOTA-LRB) was mainly in normal organs, such as kidney, heart, liver, and brain and mainly excreted from kidney. The MDA-MB-231 and MCF-7 tumors were not clearly visible in PET images at 5, 15, 30, 40, 50, and 60 min after injection of68Ga(DOTA-LRB). The tumor uptake values of18F-FDG were3.79±0.57and1.93±0.48%ID/g in MDA-MB-231 and MCF-7 tumor xenografts, respectively.Conclusions.68Ga(DOTA-LRB) can be easily synthesized with high radiochemical purity and stability; however, it may be not an ideal PET radiotracer for imaging of MDR-positive tumors.
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Tantia, M. S., P. K. Vij, RK Vijh, P. Kumar, B. K. Joshi, A. E. Nivsarkar, and R. Sahai. "SIRI: THE CATTLE OF EASTERN HIMALAYAS." Animal Genetic Resources Information 19 (April 1996): 37–43. http://dx.doi.org/10.1017/s1014233900000778.
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SUMMARYA pilot survey was conducted in the western d.istrict of Sikkim to monitor the status of the Siri cattle breed. Data was recorded on certain morphological characters, management practices and performance of Siri animals. Measurements were recorded of body length, heart girth, body height, paunch girth, hip width, pin width, face length, face width, ear length and horns on 89 animals of age groups up to 1 year,1 to 3 years and adult. It was noted that pure Siri animals were reared only in the remote inaccessible areas. Extensive crossbreeding with Jersey semen/bulls is progressively eroding the purity of the breed. Measures to conserve the Siri cattle breed in its native ecology have been advocated.
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Seyed-Gohrab, Asghar. "Rūmī’s Antinomian Poetic Philosophy." Mawlana Rumi Review 9, no. 1-2 (January 3, 2020): 159–99. http://dx.doi.org/10.1163/25898566-00901009.
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AbstractWestern reception of Rūmī in the last few decades is intriguing, as he is commonly considered a gentle Muslim, different from other sages that Islamic culture produced. Rūmī’s otherness is often based on his powerful and peerless poetry, deploying rich wine imagery, homoerotic love metaphors, and an emphasis on the superiority of the heart and spiritual growth, and dismissing the outward and orthodox tenets. This paper argues that Rūmī belongs to a millennium-old Persian Sufism, and these poetic tropes derive from a firm antinomian tradition, functioning as strong metaphors to express religious piety by transcending all temporal dualities such as unbelief and belief, the profane and the sacred, purity and impurity, and so forth.
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Houmark, Amanda. "Subjectivity and Ambiguity: Anxiety and Love in Kierkegaard." Kierkegaard Studies Yearbook 23, no. 1 (July 26, 2018): 55–73. http://dx.doi.org/10.1515/kierke-2018-0004.
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AbstractThis paper seeks to emphasize the connection between the concepts of anxiety and love as central phenomena in both Kierkegaard’s anthropology and ethics. Through the analysis of these two concepts, which Kierkegaard says “to be in the ground of man,” this paper argues that love or purity of heart should not be seen as an alternative or solution to anxiety or ambiguity. Instead, it suggests that understanding the two concepts jointly unveils how the single individual in subjectivity is in a constant flux between entangling oneself in a self-enclosed reserve on the one hand and opening up to the risks of being on 70,000 fathoms of water and yet being joyful on the other hand.
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Qu, Xiangzhen, and Shanyong Zhu. "Effect of Bone Marrow Mesenchymal Stem Cells (BMSCs) on Cardiac Function and Ventricular Remodeling in Diabetic Rat Models Through Inhibiting MicroRNA (miR)-34a." Journal of Biomaterials and Tissue Engineering 11, no. 8 (August 1, 2021): 1490–96. http://dx.doi.org/10.1166/jbt.2021.2741.
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Diabetes mellitus (DM) is harmful to heart tissue. We transplanted bone marrow mesenchymal stem cells (BMSCs) in this study to improve the function of diabetic heart. 45 rats were divided into healthy group, DM group (treated with high-fat diet), and BMSCs group (BMSCs transplantation into the ventricular wall) followed by analysis of miR-34a and aldehyde dehydrogenase 2 (ALDH2) levels, heart function, and ventricular remodeling in the three groups of rats. BMSCs were successfully cultured with high purity, and the myocardium in the BMSCs group was successfully labeled by DAPI. The left ventricular hypertrophy index and myocardial tissue CVF of rats with DM increased significantly, suggesting that ventricular remodeling in DM rats was stimulated. However, when BMSCs were transplanted to the ventricular wall, although the ventricular remodeling was not completely avoided, apoptosis of BMSCs group was significantly reduced. MiR-34a relative level in BMSCs group was obviously elevated, whereas ALDH2 level showed opposite trend with a negative relationship. MiR-34a can effectively bind to the 3′-UTR of ALDH2 mRNA, indicating that it can directly regulate gene expression. BMSCs can promote the synthesis of ALDH2 by inhibiting the expression of miR-34a, and improve the cardiac function and ventricular remodeling of diabetic rats.
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Widisuseno, Iriyanto. "ETIKA NATURAL TAOISME DAN IMPLEMENTASINYA." HUMANIKA 23, no. 2 (December 1, 2016): 49. http://dx.doi.org/10.14710/humanika.v23i2.13645.
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Ethical life according to Taoism means a way of life back to nature. Man must be able to interpret the laws of nature in an ethical perspective, and practice in the life of others. Taoism teaches life ethics need to be equipped virtue, which has a purity of heart that is sacred, or the sincerity and willingness to live for others. Taoist virtues law contains universal values, relevant for the people of Indonesia who are experiencing erosion and weakening of the appreciation of moral values. In addition, the transition period of political culture, especially from the time period of bureaucratic power to a democratic system of popular sovereignty towards civil society. Universal values of natural ethics Taoism in line with the ethical teachings of Pancasila.
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Arghirescu, Diana. "Song Neo-Confucian Conceptions of Morality and Moral Sources (Zhu Xi): Connections with Chan Buddhism." Journal of Chinese Philosophy 47, no. 3-4 (March 3, 2020): 193–212. http://dx.doi.org/10.1163/15406253-0470304006.
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In this study of ancient Confucian, Neo-Confucian (School of Principle) and Chan Buddhist ways of thinking about morality and the moral agent, my main objective is to trace changes relating to the nature and foundation of Confucian moral thought that occurred during the Song dynasty, through a parallel reading of Neo- Confucian writings and the Platform Sutra. By using the hermeneutical method and comparative textual analysis, the essay provides evidence that these changes reflect the Chan influence on Neo- Confucianism and embody a specific Neo-Confucian spirituality. The following concepts and themes articulate the theoretical framework of the research: the moral agent and moral agency; the heart-mind, authentic nature, and the principle of coherence; types of morality (substantive and procedural); and interrelatedness, oneness and purity.
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Bizzozero, Andrea. "Beati mundicordes (Mt 5, 8). Conciencia, conocimiento y Visio Dei en Agustín antes del 411." Augustinus 64, no. 1 (2019): 13–47. http://dx.doi.org/10.5840/augustinus201964252/2532.
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This article examines the link between the purity of the heart, conscience, knowledge and uisio dei. In Mt. 5:8 the vision and knowledge of God derive from a particular situation of the human heart. The vision-heart pair invites one to reflect on the anthropological structure and the conditions of possibility of the process of knowledge. The main questions here would be: How can one know God? Which faculties does one need in order to know Him? Which are the roles of the mind, the heart and the will in this knowledge? Why Augustine uses Mt. 5:8 to speak about the knowledge of God? At the same time, the expression beati mundicordes invites one to reflect on the qualities of the human condition in order to see-know God. In other words: Which features must the heart have in order to see God? If, on the one hand, it is necessary to know the starting point of this knowledge, on the other hand, it is important to show why it is in human nature to want to see God. This article will analyze the occurrences of the quotation of Mt. 5:8 in Augustine’s works before 411 in order to understand the meaning of the expression beati mundicordes and the conditions of possibility of the uisio dei. This study will investigate the Mt. 5:8 references particularly in De fide et symbolo, De sermone domini in monte, Contra Adimantum, De diuersis quaestionibus octoginta tribus, Contra epistulam Manichaei, De agone, Contra Faustum, Contra Felicem, Sancta uirginitate, ep. 92, ep. 130 and Sermo 88.
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O'Brien, Conor. "The cleansing of the temple in early medieval Northumbria." Anglo-Saxon England 44 (December 2015): 201–20. http://dx.doi.org/10.1017/s026367510008011x.
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AbstractWhile the attitudes of Stephen of Ripon and Bede toward church-buildings have previously been contrasted, this paper argues that both shared a vision of the church as a holy place, analogous to the Jewish temple and to be kept pure from the mundane world. Their similarity of approach suggests that this concept of the church-building was widespread amongst the Northumbrian monastic elite and may partially reflect the attitudes of the laity also. The idea of the church as the place of eucharistic sacrifice probably lay at the heart of this theology of sacred place. Irish ideas about monastic holiness, traditional liturgical language and the native fascination with building in stone combined with an interest in ritual purity to give power to this use of the temple-image which went on to influence later Carolingian attitudes to churches.
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Patel, Bharat, Pravin Ram, Taslimahemad Khatri, Vijay Ram, and Pragnesh Dave. "Study of Anticoagulant Dabigatran by Analytical Instrumentation." International Letters of Chemistry, Physics and Astronomy 30 (March 2014): 233–42. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.30.233.
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Dabigatran with IUPAC name 3-({2-[(4-Carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid, which can be used to prevent strokes in those with atrial fibrillation due to causes other than heart valve disease, and at least one additional risk factor for stroke (congestive heart failure, hypertension, age, diabetes, and prior stroke), with molecular formula C34H41N7H5 was studied in detail for functional group analysis with FTIR, characteristic absorbance by UV-NIR, thermal behavior by TGA-DTA-DSC, particle size and stability of the molecule with Nano particle size analyzer. The structure was confirmed by LC-MS/MS with ESI probe and mass was found in aggregation with the reported standard values. The purity of drug was determined by Prep. HPLC analysis. FTIR analysis showed the characteristic peak of carboxylic acid, UV-NIR analysis showed that the λmax was 224 nm with methanol as a diluent, the compound was found stable in the thermal analysis, the average particle size was found to be 25.2 nm, Z-average as 0.2 nm and zeta potential as -67.6 mv hence showed excellent stability in the zeta potential analysis as per ASTM standards D4187-82, American Society of Testing and Materials, 1985.
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Titov, V. N. "Phylogenesis, structure, and functional heterogeneity of arterial bed and pathogenesis of arterial hypertension." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 16, no. 3 (June 28, 2010): 333–42. http://dx.doi.org/10.18705/1607-419x-2010-16-3-333-342.
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During early phylogenesis, each forming paracrine regulated community (future structural and functional units of body organs) included a pool of specialized cells, elements of the interstitial tissue, and local peristaltic pump. In the community the pump performed the biological functions of homeostasis and endoecology (purity of the intercellular medium); the paracrine community regulated the pump via humoral factors. Later on, the development of the biological function of locomotion required a closed circulation system in which the heart and elastic arteries, as a single functional unit, have united millions of much more ancient local peristaltic pumps. We suppose that muscular arterioles are these peristaltic pumps, and the number of paracrine communities equals the number of arterioles in the body. Phylogenetically, arterial bed consists of two segments: proximal (heart and elastic arteries) and distal (muscular arterioles). Proximal segment is regulated by the vasomotor center via sympathetic and parasympathetic innervation, and distal segment (peripheral peristaltic pumps) - by paracrine communities. When the biological function of locomotion is performed, two levels of regulation are coordinated via the mechanosensitivity of the muscular arteriolar endothelium, thus providing intense cell perfusion. In the realization of the biological function of homeostasis two mechanisms of regulation are opposing, which is crucial for the pathogenesis of arterial hypertension.
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Haynes, Tony E. "Defects and Diffusion in Silicon Technology." MRS Bulletin 25, no. 7 (July 2000): 14–15. http://dx.doi.org/10.1557/mrs2000.118.
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The silicon at the heart of highperformance integrated circuits (ICs) is the most precisely engineered material in mass production today. Crystalline silicon, purified to the level required for manufacturing modern, high-performance microelectronics (better than parts-per-billion purity), is arguably the most perfect material known. It is produced in large quantities and very economically. Continuing progress in basic silicon materials science has been central to this achievement. At the same time, access to such a perfect material and detailed knowledge of silicon's properties have provided the experimentalist with excellent opportunities to devise rather elegant experiments in whichthe parameters can be controlled very precisely. Silicon has similarly provided condensed-matter theorists with a nearly ideal test bed for new theoretical approaches. This issue of MRS Bulletin is dedicated to the materials physics that has both enabled the development of such a highly perfect material and benefited from its availability.
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Gaens, Tom. "Sic vivere est devote vivere." Church History and Religious Culture 96, no. 1-2 (2016): 13–39. http://dx.doi.org/10.1163/18712428-09601002.
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This essay outlines the theology of “modern-day” devotion, as it can be found in the works of the Carthusian monk Henry of Coesfeld (d. 1410). This theology consists of a classical Thomist framework, infused with ideas from Brabantine and Rhineland mysticism (e.g., Ruusbroec, Suso) and Carthusian spirituality, in which contempt for the world, purity of the heart, progression in the virtues, repentance and inner renewal, Eucharistic piety, meditation on Christ’s humanity and passion, “Christiformity,” and the imitation of Christ, play a central role. While pointing at the “present-day” moral decline in the religious orders and the church, Henry’s idea of devotion relates to personal reform, a process of becoming congruent with the “ancient” examples of Christ and the saints. His theology is not anti-mystical and anti-intellectual in nature, but at the same time it warns against the pitfalls of curiosity (curiositas) and the excesses of mysticism.
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Lund, Mark W. "More Than One Ever Wanted To Know About X-ray Detectors." Microscopy Today 2, no. 5 (August 1994): 8. http://dx.doi.org/10.1017/s1551929500066207.
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A combination of electron microscope and x-ray spectrometer is a very powerful tool. Not only can one see a sample in great detail, but one can determine, and even map, the chemical elements. In Part 1, I discussed some of the basics of energy dispersive x-ray spectroscopy (EDS or EDX). The heart of the spectrometer is a small piece of single crystal silicon about the size and shape of a shirt button, and about twice as thick. It has been selected for high purity, and then lithium drifted to compensate the remaining impurities.The lithium is carefully drifted into the crystal button in order to exactly compensate the impurities in the crystal that would create leakage current. This is done at about 60° C under an electric field. It is then evaluated and re-drifted for a final clean up of any uncompensated impurity atoms that remain.
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Koval, D. B., N. S. Shulyak, and L. S. Logoyda. "DEVELOPMENT AND METHODOLOGY FOR THE ESTIMATION OF LISINOPRIL AND ATORVASTATIN IN PHARMACEUTICALS." Medical and Clinical Chemistry, no. 3 (December 2, 2020): 38–42. http://dx.doi.org/10.11603/mcch.2410-681x.2020.v.i3.11532.
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Introduction. The cause of hypertension and coronary heart disease in most cases is hypercholesterolemia. Therefore, for the treatment and prevention of most pharmacotherapy regimens, antiatherosclerotic drugs are used. With a high class of recommendations and level of evidence, high efficiency for primary and secondary prevention of coronary heart disease, statins are widely used in clinical practice.
The aim of the study – to improve more rapid, simple, selective, less expensive methods of thin layer chromatography analysis of simultaneous determination of lisinopril and atorvastatin in pharmaceuticals.
Research Methods. The present study assessed mobile phases of lisinopril and atorvastatin for TLC.
Results and Discussion. Thin layer chromatography can be used to: monitor the progress of a reaction, identify compounds, determine the purity of a substance. Method of simultaneous identification of lisinopril and atorvastatin by TLC was developed. We investigated different mobile phases to optimize the development of analytical methods of lisinopril and atorvastatin by TLC. It was established that the most optimal Rf observed using mobile phase ammonia R (25 %) – propanol R (30:70, v/v). We explored the validation characteristics – specificity and suitability of the chromatographic system that met, the eligibility criteria established by the SPhU.
Conclusions. We developed chromatographic method for simultaneous determination of lisinopril and atorvastatin. Propects for future research will be aimed at developing analytical methods of analysis.
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NG, ON-CHO. "AN EARLY QING CRITIQUE OF THE PHILOSOPHY OF MIND-HEART (XIN): THE CONFUCIAN QUEST FOR DOCTRINAL PURITY AND THE DOXIC ROLE OF CHAN BUDDHISM*." Journal of Chinese Philosophy 26, no. 1 (March 1999): 89–120. http://dx.doi.org/10.1111/j.1540-6253.1999.tb00533.x.
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Ng, On-Cho. "An Early Qing Critique of the Philosophy of Mind-Heart (XIV):The Confucian Quest for Doctrinal Purity and the Doxic Role of Chan Buddhism." Journal of Chinese Philosophy 26, no. 1 (February 1, 1999): 89–120. http://dx.doi.org/10.1163/15406253-02601005.
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Ozkan, Huseyin, and Enes Kerman. "Comparative Evaluation of RNAlater Solution and Snap Frozen Methods for Gene Expression Studies in Different Tissues." Revista Romana de Medicina de Laborator 28, no. 3 (July 1, 2020): 287–97. http://dx.doi.org/10.2478/rrlm-2020-0024.
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AbstractIntroduction: Freezing of tissues with liquid nitrogen is the most common method in studies performed at the RNA level. However, the use of RNA stabilization solutions has become a popular alternative method. The aim of this study is to investigate the effectiveness of RNAlater on RNA stabilization in different tissues.Material and Methods: In this study, RNA were isolated from the lung, heart, liver and skeletal muscle tissues of rats that were frozen with liquid nitrogen (snap frozen, SF group) or stored in RNAlater solution (RL group), and the changes in concentration, purity, reference genes expression, and fold-change levels between groups were analyzed.Results: In the RL group, the concentration of RNA isolated from the liver tissues was higher (P<0.05), whereas the A260/280 ratio was lower in the heart and liver tissues (P<0.05). PPIA and SRP72 genes were found to have lower Ct values in the heart tissues of rats in the RL group (P<0.05 and P<0.001, respectively) than the SF group. Expression levels of PPIA, ACTB, and SRP72 genes across the tissues were found to be different between the groups (P<0.05). The gene expression level examined in terms of fold-change was significantly different in the RL group (upregulated up to 4 folds and downregulated about 0.5 fold) (P< 0.05).Conclusions: The results showed that RNAlater can maintain the RNA integrity and can also change the results of gene expression because it does not inhibit biological activity. The snap freezing method is more reliable because gene expression is more stable in tissues frozen with liquid nitrogen.
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Tibbits, G. F., H. Kashihara, and K. O'Reilly. "Na+-Ca2+ exchange in cardiac sarcolemma: modulation of Ca2+ affinity by exercise." American Journal of Physiology-Cell Physiology 256, no. 3 (March 1, 1989): C638—C643. http://dx.doi.org/10.1152/ajpcell.1989.256.3.c638.
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The high activity of the cardiac Na+-Ca2+ exchanger has led to the suggestion that it plays an important role in the regulation of myocardial contractility. We have proposed that exercise training increases stroke volume as a consequence of an enhanced contractility caused by an adaptation in Ca2+ transport across the cardiac plasma membrane (sarcolemma). The present study examined the possibility that the Na+-Ca2+ exchanger in heart muscle is modified in response to training. Sprague-Dawley rats (female, n = 72) were randomly divided into exercise-trained (T) and sedentary control (C) groups. As a result of the 11-wk treadmill-training paradigm, group T had a 7.6% higher (P less than 0.005) heart-to-body weight ratio and a 36% increase (P less than 0.01) in gastrocnemius mitochondrial enzyme activity. Na+-Ca2+ exchange was studied in highly purified sarcolemmal vesicles using rapid-quenching techniques. The absolute initial rate of uptake was significantly higher in T vs. C at calcium concentrations [( Ca2+]) ranging from 10 to 80 microM. This increased uptake appears to be due solely to the fact that the apparent Km of the myocardial Na+-Ca2+ exchanger for Ca2+ was significantly lower in T vs. C (15.7 +/- 1.1 vs. 36.1 +/- 2.6 microM), since the maximum velocity was unchanged. The observed increase in the affinity of the exchanger for Ca2+ is not attributable to group differences in vesicular purity, cross-contamination, or passive Ca2+ efflux. This observation is consistent with observed alterations in sarcolemmal composition in response to exercise training. We propose that the modification of the Na+-Ca2+ exchanger may play an important role in the adaptation of the heart to exercise.
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Amin, M. Ruhul, Azizul Haque, Avishek Biswas, and Taufiq Hassan Mozumder. "Preparation and labeling of technitium-99m kit In pharmaceutical grade clean room." Journal of Chemical Engineering 27, no. 2 (January 29, 2014): 31–35. http://dx.doi.org/10.3329/jce.v27i2.17798.
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Technetium-99m radiopharmaceuticals are in widespread use owing to the availability and affordability of 99Mo/99m-Tc generators and the variety of kits for formulating the desired products. Together, they provide an array of specific tools for diagnosing a large number of diseases affecting the bones and major organs of the body such as the heart, brain, liver, kidney and thyroid. Nuclear medicine requires high quality radiopharmaceuticals and kits that are safe for administration and efficacious for a given application. In Bangladesh, no commercial production was done before this. This paper presents the theoretical basis of and describes the procedures for preparing three selected kits. Details of the ingredients are also included. The procedures described here can be used to develop manuals and standard operating procedures in Bangladesh. This report is expected to serve as a guide to radiopharmaceutical manufacturing centers and centralized pharmacies involved in the production of such kits in the current environment of Bangladesh. It will be a useful resource for many hospital radio pharmacy departments that routinely use the kits to compound 99m-Tc radiopharmaceuticals. Three kits namely: MDP, DMSA and DTPA were prepared. Paper Chromatography was involved to disparate the polar and non-polar part of the kit-solution and finally gamma spectrometry (HPGe) to deduce the Radiochemical Purity (RCP). By reviewing purity values, it was found that only DMSA has passed the 95% barrier which is the required percentage for safe application. This paper suggests that the findings require more practice and involve such exquisite points, which will contribute in the production of Tc-99m vivo-kits at Radioisotope Production Division (RIPD), AERE, INST and in their projected future mass production successfully. DOI: http://dx.doi.org/10.3329/jce.v27i2.17798 Journal of Chemical Engineering, IEB Vol. ChE. 27, No. 2, December 2012: 31-35
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Stockschlaeder, Marcus A., Ali Ghodsizad, Volker Stoldt, Ludger Poll, Ruediger E. Scharf, Emmeran Gams, and Michael Klein. "Intramyocardial Injection of CD133+ Bone Marrow-Derived Stem Cells Improves Cardiac Function Long-Term in the Majority of Selected Patients with End-Stage Ischemic Heart Disease." Blood 106, no. 11 (November 16, 2005): 5480. http://dx.doi.org/10.1182/blood.v106.11.5480.5480.
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Abstract To improve tissue regeneration of ischemic myocardium, autologous bone marrow-derived stem cells have been injected intramyocardially in 10 patients with end-stage ischemic heart disease. Approx. 60 – 380 ml of bone marrow were harvested from the posterior iliac crest and processed in the operating room under GMP conditions using the automated cell selection device CliniMACS. By using the Duesseldorf protocol, the intraoperative isolation of CD133+-stem cells (1.9−10.0 x 106 cells; purity up to 97%) was achieved in less than 3 hours. Following isolation, autologous CD133+-stem cells were injected in a predefined pattern into the myocardium. Cardiac function was assessed by cardiac MRI and echocardiography three, six, and nine months postoperatively. A significant improvement of cardiac function could be documented in 7 out of 10 patients: ejection fraction (EF) before treatment: 10–22% - after 3 months: 18–30% - after 6 months: 19–30%, after 9 months: 21–31%; left ventricular enddiastolic volume (LVEDV) before treatment: 210 ± 123 ml, after 3 months: 169 ± 80 ml, after 6 months: 162 ± 82 ml, after 9 months: 175 ± 70 ml; left ventricular enddiastolic diameter (LVEDD) before treatment: 79.2 ± 7 mm, after 3 months: 57.4 ± 3 mm, after 6 months: 59.4 ± 4 mm, after 9 months: 56.2 ± 5 mm, respectively. In two patients cardiac function improved only temporarily over the first three months, 1 patient died one month after surgery due to a non-cardiac cause. In conclusion, the sole intramyocardial injection of autologous CD133+-cells proved to be safe and led to a significant gain in heart function in 7 of 10 patients, thereby avoiding or postponing (“bridging”) alternative therapies such as heart transplantaton. The benefial effects of intramyocardially injected bone marrow-derived stem cells might be explained by direcct cellular effects including neovascularization and indirect effects including the formation of growth factors promoting tissue repair.
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Jose, Jobin, Teena George, and Aaron M. Thomas. "Regulation of Stem Cell-Based Research in India in Comparison with the US, EU and other Asian Countries: Current Issues and Future Perspectives." Current Stem Cell Research & Therapy 15, no. 6 (September 30, 2020): 492–508. http://dx.doi.org/10.2174/1574888x15666200402134750.
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Stem cell therapy is applicable for repair and replacement of damaged cells and tissues. Apart from transplanting cells to the body, the stem cell therapy directs them to grow new and healthy tissues. Stem cells in the area of regenerative medicines hold tremendous promise that may help to regenerate the damaged tissues and heal various diseases like multiple sclerosis, heart diseases, Parkinson’s disease, and so on. To prove the safety, efficacy, and for the requirement of a licence for manufacturing and sale, all the stem cell therapies should pass the required criteria and undergo certain examinations of the regulatory agencies. The regulatory authorities review the manufacturing procedures of products to assure its purity and potency. This review summarizes the comparative critical evaluations of existing regulations and developments on the stem cells research in India, USA, EU and Asian regions and also discusses the challenges that have to be overcome and the important points that should be understood to position India as a source of the perspective nation in stem cells around the world.
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Muzakki, Akhmad. "TITIK TEMU EPISTEMOLOGI BARAT DAN ISLAM." ULUL ALBAB Jurnal Studi Islam 10, no. 1 (December 26, 2018): 85–106. http://dx.doi.org/10.18860/ua.v10i1.6070.
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Beside ontology and axiology, the object of philosophy of science is epistemology that discusses the truth of, the method of finding, and the reality of science. ]n epistemology, there are many schools discussing the process of finding the truth of science, such as, rationalism, empiricism, criticism, phenomenology, positivism, pragmatism etc. In the trilogy of Islamic teachings, that is, iman (faith), Islam, and ihsan (perfection), generally sciences in Islam can be classified into three branches of study: (1) Ilmu Tauhid (theology), this science makes use of intellectual ability or logic (burhani method) which is epistemologically identical with rationalism; (2) Ilmu Fiqh (Islamic laws), this frequently uses bayani method, that is, inductive and deductive framework, in epistemology this method is called empiricism; (3) Ilmu Tasawwuf (mysticism), this science uses the power and purity of heart, it is called irfani method that is similar to phenomenology in Western philosophy of science. Therefore, epistemologically, basically the development of sciences in Islam cannot be separated from Western epistemological schools, that is, rationalism, empiricism, and phenomenology as well.
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Kawaguchi, Nanako. "Stem cells for cardiac regeneration and possible roles of the transforming growth factor-β superfamily." BioMolecular Concepts 3, no. 1 (February 1, 2012): 99–106. http://dx.doi.org/10.1515/bmc.2011.049.
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AbstractHeart failure is a leading cause of death worldwide. Studies of stem cell biology are essential for developing efficient treatments. Recently, we established and characterized c-kit-positive cardiac stem cells from the adult rat heart. Using a MethoCult culture system with a methyl-cellulose-based medium, stem-like left-atrium-derived pluripotent cells could be regulated to differentiate into skeletal/cardiac myocytes or adipocytes with almost 100% purity. Microarray and pathway analyses of these cells showed that transforming growth factor-β1 (TGF-β1) and noggin were significantly involved in the differentiation switch. Furthermore, TGF-β1 may act as a regulator for this switch because it simultaneously inhibits adipogenesis and activates myogenesis in a dose-dependent manner. However, the effect of TGF-β varies with developmental stage, dosage, and timing of treatment. In the present review, the findings of recent studies, in particular the use of c-kit-positive cardiac stem cells, are discussed. The effects of the TGF-β superfamily on differentiation, especially on adipogenesis and/or myogenesis, have important implications for future regenerative medicine.
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Krasny, Lukas, Angela Paul, Patty Wai, Beatrice A. Howard, Rachael C. Natrajan, and Paul H. Huang. "Comparative proteomic assessment of matrisome enrichment methodologies." Biochemical Journal 473, no. 21 (October 27, 2016): 3979–95. http://dx.doi.org/10.1042/bcj20160686.
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The matrisome is a complex and heterogeneous collection of extracellular matrix (ECM) and ECM-associated proteins that play important roles in tissue development and homeostasis. While several strategies for matrisome enrichment have been developed, it is currently unknown how the performance of these different methodologies compares in the proteomic identification of matrisome components across multiple tissue types. In the present study, we perform a comparative proteomic assessment of two widely used decellularisation protocols and two extraction methods to characterise the matrisome in four murine organs (heart, mammary gland, lung and liver). We undertook a systematic evaluation of the performance of the individual methods on protein yield, matrisome enrichment capability and the ability to isolate core matrisome and matrisome-associated components. Our data find that sodium dodecyl sulphate (SDS) decellularisation leads to the highest matrisome enrichment efficiency, while the extraction protocol that comprises chemical and trypsin digestion of the ECM fraction consistently identifies the highest number of matrisomal proteins across all types of tissue examined. Matrisome enrichment had a clear benefit over non-enriched tissue for the comprehensive identification of matrisomal components in murine liver and heart. Strikingly, we find that all four matrisome enrichment methods led to significant losses in the soluble matrisome-associated proteins across all organs. Our findings highlight the multiple factors (including tissue type, matrisome class of interest and desired enrichment purity) that influence the choice of enrichment methodology, and we anticipate that these data will serve as a useful guide for the design of future proteomic studies of the matrisome.