Academic literature on the topic 'Puumala virus'
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Journal articles on the topic "Puumala virus"
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Fakhrai, Negar, Christina Mueller-Mang, Karem El-Rabadi, Georg A. Böhmig, and Christian J. Herold. "Puumala Virus Infection." Journal of Thoracic Imaging 26, no. 2 (2011): W51—W53. http://dx.doi.org/10.1097/rti.0b013e3181d29dfd.
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Billecocq, A., D. Coudrier, F. Boué, et al. "Expression of the Nucleoprotein of the Puumala Virus from the Recombinant Semliki Forest Virus Replicon: Characterization and Use as a Potential Diagnostic Tool." Clinical Diagnostic Laboratory Immunology 10, no. 4 (2003): 658–63. http://dx.doi.org/10.1128/cdli.10.4.658-663.2003.
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ABSTRACT Puumala virus (Bunyaviridae family, Hantavirus genus) causes a mild form of hemorrhagic fever with renal syndrome (HFRS) called nephropathia epidemica in northern and central Europe. Serological tests are used for diagnosis, but antigen production is difficult because the virus grows poorly in tissue culture. We expressed the N protein (nucleoprotein) of Puumala virus via the Semliki Forest virus (SFV) replicon in mammalian cells and compared its antigenic properties with those of the native antigen derived from Puumala virus-infected cells. Detection of immunoglobulin G or immunoglobulin M by enzyme-linked immunosorbent assay (ELISA), μ-capture ELISA, and indirect immunofluorescence assay was (at least) as effective with the recombinant antigen as with the native antigen when HFRS patient sera or organ washes from wild rodents were tested. No nonspecific reaction was observed. Thus, the SFV-expressed N protein of Puumala virus appears as a valid antigen, specific and sensitive for serological investigations.
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Rose, Angie, O. Vapalahti, O. Lyytikäinen, and P. Nuorti. "Patterns of Puumala virus infection in Finland." Eurosurveillance 8, no. 1 (2003): 9–13. http://dx.doi.org/10.2807/esm.08.01.00394-en.
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Puumala hantavirus infection is prevalent throughout most of Europe, and in endemic areas it may be the most common cause of acute renal failure. To evaluate trends in incidence of Puumala virus infections in Finland, we analysed national surveillance data in 12-month periods from March 1995 to February 2002. During this time, 8184 laboratory-confirmed cases were notified to the National Infectious Disease Register. Three epidemic periods were identified, for which the number of cases was more than 1400 (there were approximately 600-900 cases per non-epidemic period). The incidence of Puumala hantavirus infection varied by geographic region during the study period, and the overall number of cases may be increasing.
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Straková, Petra, Sandra Jagdmann, Linas Balčiauskas, Laima Balčiauskienė, Stephan Drewes, and Rainer G. Ulrich. "Puumala Virus in Bank Voles, Lithuania." Emerging Infectious Diseases 23, no. 1 (2017): 158–60. http://dx.doi.org/10.3201/eid2301.161400.
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Pettersson, Lisa, Jens Boman, Per Juto, Magnus Evander, and Clas Ahlm. "Outbreak of Puumala Virus Infection, Sweden." Emerging Infectious Diseases 14, no. 5 (2008): 808–10. http://dx.doi.org/10.3201/eid1405.071124.
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Finsterer, Josef, Andreas Valentin, Claudia Stöllberger, Martin Jankovic, and Christian Prainer. "Puumala virus infection with multiorgan involvement." Intensive Care Medicine 29, no. 3 (2003): 501–2. http://dx.doi.org/10.1007/s00134-002-1626-6.
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Vetter, Pauline, Arnaud G. L’Huillier, Maria F. Montalbano, et al. "Puumala Virus Infection in Family, Switzerland." Emerging Infectious Diseases 27, no. 2 (2021): 658–60. http://dx.doi.org/10.3201/eid2702.203770.
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Meisel, Helga, Anne Wolbert, Ausra Razanskiene, et al. "Development of Novel Immunoglobulin G (IgG), IgA, and IgM Enzyme Immunoassays Based on Recombinant Puumala and Dobrava Hantavirus Nucleocapsid Proteins." Clinical and Vaccine Immunology 13, no. 12 (2006): 1349–57. http://dx.doi.org/10.1128/cvi.00208-06.
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ABSTRACT Human infections with Asian and European hantaviruses can result in hemorrhagic fever with renal syndromes of differing severities characterized by renal dysfunction and sometimes by pulmonary symptoms. For the serological detection of human infections by hantaviruses relevant for Europe, we developed monoclonal antibody capture immunoglobulin G (IgG) and IgA enzyme-linked immunosorbent assays (ELISAs) based on yeast-expressed nucleocapsid proteins of Puumala and Dobrava hantaviruses. Moreover, for diagnosis of acute infections, μ-capture IgM ELISAs were established with nucleocapsid proteins expressed in Drosophila melanogaster Schneider S2 cells. The cutoff values of the ELISAs were determined by investigation of up to 500 human anti-hantavirus-negative serum samples. The specificities of the Puumala and Dobrava virus-specific IgM, IgA, and IgG ELISAs were found to be 100%. The sensitivities of these ELISAs were determined to be 100% with panels of characterized anti-Puumala or anti-Dobrava virus-positive human serum samples. In most cases, Puumala and Dobrava virus infections could be differentiated by ELISA reactivity alone, i.e., endpoint titration with homologous and heterologous antigens.
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Sironen, Tarja, Antti Vaheri, and Alexander Plyusnin. "Molecular Evolution of Puumala Hantavirus." Journal of Virology 75, no. 23 (2001): 11803–10. http://dx.doi.org/10.1128/jvi.75.23.11803-11810.2001.
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ABSTRACT Puumala virus (PUUV) is a negative-stranded RNA virus in the genusHantavirus, family Bunyaviridae. In this study, detailed phylogenetic analysis was performed on 42 complete S segment sequences of PUUV originated from several European countries, Russia, and Japan, the largest set available thus far for hantaviruses. The results show that PUUV sequences form seven distinct and well-supported genetic lineages; within these lineages, geographical clustering of genetic variants is observed. The overall phylogeny of PUUV is star-like, suggesting an early split of genetic lineages. The individual PUUV lineages appear to be independent, with the only exception to this being the Finnish and the Russian lineages that are closely connected to each other. Two strains of PUUV-like virus from Japan form the most ancestral lineage diverging from PUUV. Recombination points within the S segment were searched for and evidence for intralineage recombination events was seen in the Finnish, Russian, Danish, and Belgian lineages of PUUV. Molecular clock analysis showed that PUUV is a stable virus, evolving slowly at a rate of 0.7 × 10−7 to 2.2 × 10−6 nt substitutions per site per year.
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Tkachenko, E. A., V. G. Morozov, T. K. Dzagurova, et al. "Etiologic and clinical epidemiological features of hemorrhagic fever with renal syndrome (HFRS) in the Krasnodar Krai." Epidemiology and Infectious Diseases 21, no. 1 (2016): 22–30. http://dx.doi.org/10.17816/eid40880.
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The purpose of the study is the investigation of etiological, clinical and epidemiological features of HFRS, caused by Sochi virus in the Krasnodar area, as well as a comparative analysis of the data with those of HFRS, caused by Kurkino virus in the Central Russian regions and Puumala virus in the areas of Volga region. Materials and methods For the identification of HFRS patients, sera from more than 800 acute febrile patients residing in Krasnodar area were examined for hantavirus antibody by IFA with Puumala, Hantaan, Seoul, Sochi, Kurkino and Dobrava viruses. For primary screening there was used the indirect immunofluorescence (ELISA) method with polyvalent cultural antigen as for serotyping of positive sera according to affiliation of antibodies to various Hantaviruses species, there were used ELISA method with monovalent cultural antigens and the neutralization reaction with Puumala, Hantaan, Seoul, Sochi, Kurkino and Dobrava viruses with the use of the method of Inhibition of Focus-Forming Units assay. Clinical and epidemiological studies have been performed on the base of history cases and records of the epidemiological examination. Results of the study. During 2000 - 2013 there were identified 64 patients suffered from HFRS caused by the Sochi virus. The patients resided in 36 settlements of 10 administrative districts of the Krasnodar area. A comparative analysis of clinical, laboratory and epidemiological data of patients with HFRS-Sochi, HFRS-Kurkino and HFRS-Puumala viruses allowed to reveal differences between the clinical (frequency of registration and severity of several symptoms, severity of the course and mortality rate) and epidemiological (prevalence in rural and urban residents, occupational pattern, the seasonality of the disease, conditions of contamination) manifestations. Conclusion There was established the etiological and epidemiological importance of Sochi virus. Sochi virus causes sporadic annual incidence of HFRS in the territory of Krasnodar area. Cases of HFRS caused by the Sochi virus are differ in more severe course of the disease and high lethality rate in comparison with the other two forms of HFRS caused by Puumala and Kurkino viruses in the territory of the European part of Russia.
Dissertations / Theses on the topic "Puumala virus"
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Ahlm, Clas. "Distribution of puumala virus in Sweden." Doctoral thesis, Umeå universitet, Infektionssjukdomar, 1997. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140825.
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Puumala virus, belonging to the genus hantavirus, is the causative agent of nephropathia epidemica (NE), a relatively mild form of hemorrhagic fever with renal syndrome. Puumala virus occurs endemically in Central and Northern Europe and Western Russia. In Sweden, NE is reported from the northern and central parts but virtually not at all from the southern part of the country. The bank vole (Clethrionomys glareolus) is the main reservoir of Puumala virus and humans are infected by inhalation of aerosolized animal secreta. In northern Sweden, the density of the bank vole population varies cyclically in intervals of 3-4 years and the incidence of NE shows a covariation. The prevalence of serum antibodies to hantaviruses in northern Sweden was studied in a stratified and randomly selected adult population sample comprising 1538 subjects. As expected, the prevalence increased with age. There was no difference between men and women, which was unexpected based on a male:female ratio of > 2:1 in clinical reports. By use of an immunofiuorescent assay, a seroprevalence of 5.4% and by a newly developed enzyme-linked immunosorbent assay (ELISA) with recombinant Puumala virus nucleocapsid protein as antigen, a prevalence of 8.9% was recorded. This is about or more than ten times higher than what would be calculated from clinical reports. By use of the ELISA, an occupational risk of acquisition of Puumala virus infection was demonstrated. Serum samples from 910 farmers and 663 referent subjects living in various rural parts of Sweden were tested. Among farmers from the Puumala virus-endemic northern and central parts of the country, the seroprevalence (12.9%) was higher (p=0.01) than in referents (6.8%). In the southern part of Sweden, only 2/459 persons had antibodies. Only a limited number of children with NE had been previously reported. In a separate study, 32 children with Puumala virus infection were identified and the clinical picture of NE in children was found to be similar to that of adult cases. Variations in the prevalence of Puumala virus in the bank vole population within an endemic region are not well known. Here, a higher mean rodent density and a higher prevalence of Puumala virus-specific serum antibodies were recorded in the vicinity of households afflicted with NE than in rural control areas. The data indicated that the risk of exposure locally within an endemic region may vary widely and tentatively suggested that a threshold density of bank voles might be necessary to achieve before effective spread of Puumala virus within the rodent population may occur. There is no firm evidence of the occurrence of Puumala virus among wild living animals other than rodents. A study of Swedish moose, an animal which is ecologically well characterized, was performed. Convincing evidence of past Puumala virus infection was found in 5/260 moose originating from Puumala virus-endemic areas but in none of 167 animals from nonendemic areas. Based on the low seroprevalence recorded, moose seemed to serve as endstage hosts rather than being active parts of the enzootic circle of transmission. In conclusion, the present investigations confirmed that the exposure to Puumala virus is geographically well restricted in Sweden. Seroprevalence studies indicated that only a minor proportion of individuals infected with Puumala virus are clinically reported, with a bias in favour of men. NE was confirmed to occur in children, with a clinical picture similar to that of adults. An occupational risk was defined for acquisition of Puumala virus infection. Studies in rodents suggested that there may be wide local variations within a limited area in the risk of exposure to Puumala virus. The studies validated the usefulness of a newly developed ELISA based on recombinant nucleocapsid peptides of hantaviruses and finally, methodological progress was reached when Puumala virus was, for the first time, successfully isolated from a Scandinavian patient.<br><p>Diss. (sammanfattning) Umeå : Umeå universitet, 1998</p><br>digitalisering@umu
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Carvalho, Nicacio Cristina de. "Puumala hantavirus : immune responses and vaccines /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-156-X.
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Koudriakova, Elina. "Characterisation of the host response to Puumala virus infection." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/30771/.
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The family Hantaviridae, of the Bunyavirales order, contains many important human pathogens of which Puumala virus (PUUV) is the most widely distributed member in Europe. It causes nephropathia epidemica, a milder form of haemorrhagic fever with renal syndrome and mortality rates of up to 1% have been reported. They are enveloped viruses, with a tripartite single-stranded negative sense RNA genome, that replicate solely in the cell cytoplasm. Several factors have been proposed to play a role in hantavirus pathogenicity, including regulation of innate immune responses, cell signalling and enhancement of endothelial cell permeability. The work presented in this thesis describes biological and molecular characterisation of the mechanisms behind a hantavirus infection. Transcriptome analysis was a valuable tool that allowed the investigation of the broader picture of the effect of PUUV on the host cell. 549 and as many as 7,283 genes were differentially expressed at 24 and 48 hours post infection, respectively, in PUUV-infected cells, revealing extensive transcriptional change. By 48 hours normal cellular function appeared severely disrupted. Most genes involved in mitochondrial functioning were down-regulated, suggesting a reduced cellular energy level. Dysregulation of an important signalling hub such as mitochondria might have a more global impact on cellular functions, consistent with findings in this study. Intrinsic apoptosis pathway, which is mediated by mitochondria, appeared inhibited. Whereas, death receptor signalling was activated. Pathways associated with actin formation, organisation and signalling also appeared inhibited. Members of Rho family of GTPases, which are key regulators of actin dynamics, were down-regulated overall. Furthermore, integrin signalling, which mediates Rho GTPase activity, was also inhibited. Immunofluorescence studies revealed marked morphological changes in mitochondria and substantial remodelling of the actin cytoskeleton. Further analysis revealed a direct interaction between PUUV N protein and anillin, a scaffolding protein that mediates formation and organisation of actin filaments, suggesting a potential novel mechanism behind actin cytoskeleton reorganisation. Biological interferon (IFN) assays enabled the identification of two IFN antagonists encoded by PUUV, the cytoplasmic tail of the Gn glycoprotein and the non-structural protein, NSs. The Gn tail inhibited type I IFN induction at the level of TRAF3-TBK, in agreement with previous studies on other hantaviruses. Whereas, NSs was found to block IFN induction downstream of IRF3, suggesting it was able to disrupt transcription or translation. Utilising immunofluorescence and chromatin immunoprecipitation methods, it was found that PUUV NSs possessed a potential mechanism to inhibit transcription by blocking serine 2 phosphorylation at the C-terminal domain of RNA polymerase II in a similar manner to the previously described Bunyamwera virus NSs. The data presented in this thesis illustrates the broad range of mechanisms employed by PUUV to alter cell function to aid virus replication and subvert innate immune responses.
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Thunberg, Therese. "Study of pathogenesis and immune response in human Puumala virus infection." Doctoral thesis, Umeå universitet, Institutionen för klinisk mikrobiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-76706.
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Hantaviruses can cause two severe human diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). Hantaviruses are spread to humans mainly through inhalation of infectious virions, secreted from infected rodents. The human diseases are characterized by an increased capillary leakage syndrome. Hantaviruses are known to infect endothelial cells, but they are non-cytopathogenic. The mechanism behind human disease is not well understood, but an overactive immune response is implicated in the pathogenesis. The aim of my thesis has been to investigate parts of innate and adaptive immune responses in Puumala virus-infected patients. In paper I we found a sex difference in the cytokine profile during acute infection. Females had significantly higher plasma levels of IL-9, FGF-2, GM-CSF and lower levels of IL-8 and IP-10 compared to males. These differences may affect the activation and function of the immune response. In paper II we studied the phenotype and kinetics of NK cells. We observed that CD56dim NK cells were elevated during acute infection and that these, predominantly NKG2C+ NK cells, remained elevated for at least two months after symptom debut. Our novel finding of a prolonged NK cell response, implicates that NK cells may possess adaptive immunity features. In paper III we observed a vigorous cytotoxic T cell (CTL) response during acute infection, which contracted in parallel with decrease in viral load. The CTL response was not balanced by an increase in regulatory T cells. The T cells expressed inhibitory immunoregulatory receptors, known to dampen intrinsic T cell activity. In paper IV, we found that a low IgG response in patients was significantly associated with more severe disease, while the viral load did not affect the outcome. Our findings support the use of passive immunization as a treatment alternative for hantavirus-infected patients. In conclusion, my thesis contributes to an increased knowledge about the immune response in hantavirus-infected patients. The findings, combined with future studies, will hopefully lead to a better understanding of the pathogenesis and possible treatment alternatives.
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Khattak, Shahryar, Gholamreza Darai, Sandor Süle, and Angela Rösen-Wolff. "Characterization of Expression of Puumala Virus Nucleocapsid Protein in Transgenic Plants." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-137547.
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Transgenic plants expressing a foreign gene are a suitable system for the production of relevant immunogens in high amounts that can be used for the development of a new generation of vaccines against a variety of infectious diseases. In the present study, the expression of the nucleocapsid (N) protein of hantavirus serotype Puumala in tobacco and potato plants was investigated. Transgenic tobacco and potato plants were generated and established. These transgenic plants expressed the N protein of Puumala virus strain CG-1820. No major differences were observed when the phenotype and growth rates of transgenic plants were compared to those of normal plants. However, it was found that the leaves of transgenic tobacco plants were more slender and the tubers of transgenic potato plants were smaller than those in normal plants. In order to investigate the distribution of the expression of the foreign gene in transgenic plants, the proteins of leaves and roots of the individual transgenic tobacco and potato plants were examined by Western blot analyses. It was found that all transgenic tobacco and potato plants expressed the N protein in the leaves, whereas transgenic potato plants are able to significantly express the viral proteins also in the tubers and roots. The antigens were expressed at a level of 1 ng of protein/5 μg of dried leaves. The hantaviral recombinant N proteins obtained from transgenic tobacco and potato plants were able to elicit specific humoral and mucosal immune responses when administered intraperitoneally or orally to rabbits and mice. The expression of viral proteins in plants has two major advantages compared to other expression systems: firstly, there is no risk of contamination with mammalian viruses or other pathogens, and secondly, the production of high amounts of antigens is cheap and therefore of great economic interest<br>Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich
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Khattak, Shahryar, Gholamreza Darai, Sandor Süle, and Angela Rösen-Wolff. "Characterization of Expression of Puumala Virus Nucleocapsid Protein in Transgenic Plants." Karger, 2002. https://tud.qucosa.de/id/qucosa%3A27739.
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Transgenic plants expressing a foreign gene are a suitable system for the production of relevant immunogens in high amounts that can be used for the development of a new generation of vaccines against a variety of infectious diseases. In the present study, the expression of the nucleocapsid (N) protein of hantavirus serotype Puumala in tobacco and potato plants was investigated. Transgenic tobacco and potato plants were generated and established. These transgenic plants expressed the N protein of Puumala virus strain CG-1820. No major differences were observed when the phenotype and growth rates of transgenic plants were compared to those of normal plants. However, it was found that the leaves of transgenic tobacco plants were more slender and the tubers of transgenic potato plants were smaller than those in normal plants. In order to investigate the distribution of the expression of the foreign gene in transgenic plants, the proteins of leaves and roots of the individual transgenic tobacco and potato plants were examined by Western blot analyses. It was found that all transgenic tobacco and potato plants expressed the N protein in the leaves, whereas transgenic potato plants are able to significantly express the viral proteins also in the tubers and roots. The antigens were expressed at a level of 1 ng of protein/5 μg of dried leaves. The hantaviral recombinant N proteins obtained from transgenic tobacco and potato plants were able to elicit specific humoral and mucosal immune responses when administered intraperitoneally or orally to rabbits and mice. The expression of viral proteins in plants has two major advantages compared to other expression systems: firstly, there is no risk of contamination with mammalian viruses or other pathogens, and secondly, the production of high amounts of antigens is cheap and therefore of great economic interest.<br>Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
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Drewes, Stephan [Verfasser]. "Reservoir-driven inhomogeneous distribution of human Puumala virus cases in Central Europe / Stephan Drewes." Greifswald : Universitätsbibliothek Greifswald, 2016. http://d-nb.info/1116432986/34.
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Guivier, Emmanuel. "Variabilité de la résistance/tolérance des campagnols roussâtres à lhantavirus Puumala et conséquences épidémiologiques." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20194.
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Le campagnol roussâtre Myodes glareolus est le réservoir principal de l'hantavirus Puumala (PUUV) responsable de la néphropathie épidémique (NE) en Europe. L'objectif de cette thèse est de décrire la variabilité de la résistance / tolérance de M. glareolus à PUUV et d'explorer son rôle dans la distribution et la transmission de ce virus. Nous émettons l'hypothèse que la tolérance à PUUV favorise sa persistance et sa transmission, ce qui devrait accroître le risque d'émergence de la NE. Nous avons développé une approche gène candidat pour déterminer le rôle de trois gènes de l'immunité dans la résistance / tolérance à PUUV. L'existence d'associations positives entre les allèles du gène Drb et l'infection par PUUV d'une part et les relations négatives détectées entre le niveau d'expression du gène Tnf-α et la prévalence en PUUV d'autre part corroborent l'évolution d'une tolérance en zones d'endémie de la NE. Elle pourrait être sélectionnée en réponse au coût de la réponse inflammatoire développée contre PUUV. L'approche de génétique des populations a démontré le rôle de la dynamique des réservoirs dans l'épidémiologie de PUUV. La comparaison du polymorphisme des gènes Drb et Tnf-α et des patrons génétiques neutres semble cependant indiquer une faible influence de la sélection dans le polymorphisme de ces gènes. Ce résultat suggère un effet potentiellement important de la plasticité phénotypique dans les niveaux de résistance/tolérance observés. L'étude de la communauté d'helminthes a confirmé cette hypothèse en révélant l'impact de certaines espèces sur le risque d'infection à PUUV<br>The bank vole Myodes glareolus is the main reservoir of Puumala hantavirus (PUUV), the agent of nephropathia epidemica (NE) in Europe. This work aims at describing the variability of M. glareolus resistance / tolerance to PUUV and at exploring its role in the distribution and transmission of the virus. We hypothesized that tolerance to PUUV should favour its persistence and transmission, what could increase the risk of NE emergence.We developed a candidate gene approach to determine the role of three immune genes in the resistance / tolerance to PUUV. Both the detection of positive associations between Drb alleles and PUUV infection and the negative relationship observed between Tnf-α gene expression and PUUV prevalence corroborated the evolution of tolerance in NE endemic areas. The costly inflammatory response activated against PUUV infection could mediate this evolution.Using landscape population genetics, we revealed the role of M. glareolus population dynamics in PUUV epidemiology. The comparison of Drb and Tnf-α genetic differentiation with the neutral pattern detected at microsatellites indicated that selection weakly acted on these immune genes. This result suggested the potential effect of phenotypic plasticity in the balance of resistance/tolerance to PUUV. The study of helminth communities confirmed this hypothesis as it revealed the impact of two nematode species on the risk of PUUV infection
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Johansson, Patrik. "Implications of Local Puumala Hantavirus Genetics and Epidemiology for Diagnostics and Vaccine Development." Doctoral thesis, Umeå : Klinisk mikrobiologi, Umeå universitet, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-532.
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Bertrand-Cervi, Claire. "Evaluation d'un test rapide de détection des IgM anti Puumala virus et son intérêt dans la prise en charge du patient dans un service du centre hospitalier de Charleville-Mézières." Reims, 2009. http://www.theses.fr/2009REIMP075.
Full textBook chapters on the topic "Puumala virus"
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"Puumala-Virus." In Lexikon der Infektionskrankheiten des Menschen. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-39026-8_914.
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"Puumala Virus." In Molecular Detection of Human Viral Pathogens. CRC Press, 2016. http://dx.doi.org/10.1201/b13590-65.
Full textConference papers on the topic "Puumala virus"
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Kramer, V., EC Weiss, F. Moser, et al. "Puumala-Virus Infektion in der Spätschwangerschaft. Ein Fallbericht." In Kongressabstracts zur Gemeinsamen Jahrestagung der Österreichischen Gesellschaft für Gynäkologie und Geburtshilfe (OEGGG) und der Bayerischen Gesellschaft für Geburtshilfe und Frauenheilkunde e.V. (BGGF). Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1730487.
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