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Journal articles on the topic 'PV 5.0'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Lindinger, Michael I., L. J. McCutcheon, G. L. Ecker, and R. J. Geor. "Heat acclimation improves regulation of plasma volume and plasma Na+ content during exercise in horses." Journal of Applied Physiology 88, no. 3 (2000): 1006–13. http://dx.doi.org/10.1152/jappl.2000.88.3.1006.

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This study determined the plasma volume (PV) and ion responses to heat acclimation and exercise in six trained Thoroughbred horses during 21 days of exposure to heat and humidity (33°C, 83% relative humidity) for 4 h/day. During the 2nd h on days 0, 3, 7, 14, and 21, horses performed a standardized treadmill test, running at 50% of peak O2uptake until pulmonary artery temperature reached 41.5°C. Heat acclimation resulted in an increase in PV from 21.3 ± 1.1 liters on day 0 to 24.3 ± 1.0 liters on day 14, returning to 22.6 ± 0.9 liters on day 21. The corresponding total plasma protein contents

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2

Ogawa, Tomoko, Yoshimi Tomita, Mineyuki Okada, et al. "Broad-spectrum detection of papillomaviruses in bovine teat papillomas and healthy teat skin." Journal of General Virology 85, no. 8 (2004): 2191–97. http://dx.doi.org/10.1099/vir.0.80086-0.

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To investigate the prevalence of bovine papillomavirus (BPV) in bovine papilloma and healthy skin, DNA extracted from teat papillomas and healthy teat skin swabs was analysed by PCR using the primer pairs FAP59/FAP64 and MY09/MY11. Papillomavirus (PV) DNA was detected in all 15 papilloma specimens using FAP59/FAP64 and in 8 of the 15 papilloma specimens using MY09/MY11. In swab samples, 21 and 8 of the 122 samples were PV DNA positive using FAP59/FAP64 and MY09/MY11, respectively. Four BPV types (BPV-1, -3, -5 and -6), two previously identified putative BPV types (BAA1 and -5) and 11 putative

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3

Narechania, Apurva, Masanori Terai, Zigui Chen, Rob DeSalle, and Robert D. Burk. "Lack of the canonical pRB-binding domain in the E7 ORF of artiodactyl papillomaviruses is associated with the development of fibropapillomas." Journal of General Virology 85, no. 5 (2004): 1243–50. http://dx.doi.org/10.1099/vir.0.19765-0.

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The L-X-C-X-E pRB-binding motif of papillomavirus (PV) E7 proteins has been implicated in the immortalization and transformation of the host cell. However, sequencing of the complete genomes of bovine papillomavirus type 3 (BPV-3), bovine papillomavirus type 5 (BPV-5), equine papillomavirus (EQPV) and reindeer (Rangifer tarandus) papillomavirus (RPV) supports the notion that the pRB-binding motif is not ubiquitous among E7 proteins in the PV proteome. Key among the animal groups that lack the pRB-binding domain are the artiodactyl PVs, including European elk PV (EEPV), deer PV (DPV), reindeer

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4

Teofili, Luciana, Maurizio Martini, Tonia Cenci, Luigi M. Larocca, and Giuseppe Leone. "Combined Muliparameter Approach to the Diagnosis of Polycythemia Vera and Essential Thrombocythemia." Blood 106, no. 11 (2005): 4950. http://dx.doi.org/10.1182/blood.v106.11.4950.4950.

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Abstract The diagnosis of Polycythemia Vera (PV) and Essential Thrombocythemia (ET) is currently performed by excluding possible causes of secondary erythrocytosis and thrombocythosis. Recently, new typical findings of Ph-negative myeloprolipherative syndromes have been described, such as the PRV-1 RNA over-expression and the Val617Phe JAK-2 mutation. In this study we evaluated the diagnostic value of endogenous erythroid colony-assay (EECs), PRV-1 RNA over-expression and JAK-2 mutation, in the screening of patients with thrombocytosys and erythrocytosis which are candidate to a more extensive

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5

Hoeg, Rasmus T., Dean A. Jobe, Krista E. Asp, et al. "Circulating Endothelial Cells and Circulating Endothelial Progenitor Cells in Polycythemia Vera." Blood 108, no. 11 (2006): 4900. http://dx.doi.org/10.1182/blood.v108.11.4900.4900.

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Abstract Background: Angiogenesis and thrombosis, two conditions associated with perturbation of the vascular endothelium and increased CECs, are frequently observed in PV. We performed this study to quantify and characterize CECs in patients with PV and to determine whether CEC profile is associated with thrombotic complications. We also quantified CEPs in a subgroup of patients. Methods: We used flow cytometry to prospectively analyze CECs and CEPs in the whole blood of healthy patients (n=20) and patients with PV (n=30; 13 treated with hydroxyurea, 12 undergoing phlebotomy alone, and 5 neve

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6

Hidalgo Lopez, Juliana, Rashmi Kanagal-Shamanna, Bryce Macek, et al. "Splicing Factor Pathway Is Rarely Mutated in Myeloid Blast Phase of PV with Dysmyelopoiesis and Ring Sideroblast." Blood 132, Supplement 1 (2018): 4309. http://dx.doi.org/10.1182/blood-2018-99-116589.

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Abstract Introduction: BP of PV presents with dyserythropoiesis, including ring sideroblasts, and bilineage dysplasia in most cases. Clonal evolution or acquisition of new cytogenetic clone(s) plays a critical role in progression to BP of PV. SF3B1 mutation is associated with 75% of MDS with ring sideroblasts (RS). We hypothesized that an increase in ring sideroblast counts is an early event in the BP evolution. We postulate that genomic lesions other than in splicing factors genes are implicated in RS development in PV during BP evolution. Methods: We identified all cases in the last 14 years

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7

Puspasari, Amalia Rahmi, Eko Nurcahya Dewi, and Laras Rianingsih. "Aplikasi Antioksidan dari Ekstrak Lamun (Cymodocea rotundata) pada Minyak Ikan Tongkol (Euthynnus affinis)." Agritech 37, no. 2 (2017): 115. http://dx.doi.org/10.22146/agritech.25324.

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Cymodocea rotundata is a seagrass, has a potential antioxidant capacity due to have flavonoid and phenolic compounds that could prevent free radicals. This research aimed was to determine the effect of different concentrations of seagrass extracts on the value of free fatty acids (FFA), peroxide value (PV), and thiobarbituric acid (TBA) during storage at room temperature. The material used in this study was swordfish which were processed into fish oil. The research was conduct through laboratory experiments using a completely randomized design (CRD) which to evaluate the effect of seagrass ext

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8

Iurlo, Alessandra, Umberto Gianelli, Alessia Moro, et al. "Early-Polycythemia Vera (e-PV) with Thrombocytosis: Clinical Characteristics, Morphological Features and JAK2V617F Mutational Status Contributing to the Differential Diagnosis with Essential Thrombocythemia." Blood 108, no. 11 (2006): 3628. http://dx.doi.org/10.1182/blood.v108.11.3628.3628.

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Abstract According to the recently published WHO classification, two well-defined stages of PV, known as polycythemic phase and post-polycythemic myelofibrosis, are clearly recognizable. A few years ago, it has been reported that erythrocytosis may develop in the course of ET, and that PV may present in the early stage of the disease with an elevated platelet count, mimicking ET. Recently, it has been suggested that PV could be preceded by an “early” phase of the disease (Thiele et al, 2005), in which the increase in the red cell mass or hemoglobin level are lower than requested for the diagno

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9

Arita, Minetaro, Takaji Wakita, and Hiroyuki Shimizu. "Characterization of pharmacologically active compounds that inhibit poliovirus and enterovirus 71 infectivity." Journal of General Virology 89, no. 10 (2008): 2518–30. http://dx.doi.org/10.1099/vir.0.2008/002915-0.

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Poliovirus (PV) and enterovirus 71 (EV71) cause severe neurological symptoms in their infections of the central nervous system. To identify compounds with anti-PV and anti-EV71 activities that would not allow the emergence of resistant mutants, we performed drug screening by utilizing a pharmacologically active compound library targeting cellular factors with PV and EV71 pseudoviruses that encapsidated luciferase-encoding replicons. We have found that metrifudil (N-[2-methylphenyl]methyl)-adenosine) (an A2 adenosine receptor agonist), N 6-benzyladenosine (an A1 adenosine receptor agonist) and

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10

Navas-Cortés, Juan A., Blanca B. Landa, Miguel A. Méndez-Rodríguez, and Rafael M. Jiménez-Díaz. "Quantitative Modeling of the Effects of Temperature and Inoculum Density of Fusarium oxysporum f. sp. ciceris Races 0 and 5 on Development of Fusarium Wilt in Chickpea Cultivars." Phytopathology® 97, no. 5 (2007): 564–73. http://dx.doi.org/10.1094/phyto-97-5-0564.

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Races 0 (Foc-0) and 5 (Foc-5) of Fusarium oxysporum f. sp. ciceris differ in virulence and induce yellowing or wilting syndrome, respectively, in chickpea. We modeled the combined effects of soil temperature and inoculum density of Foc-0 and Foc-5 on disease developed in chickpea cvs. P-2245 and PV-61 differing in susceptibility to those races, using quantitative nonlinear models. Disease development over time in the temperature range of 10 to 30°C and inoculum densities between 6 and 8,000 chlamydospores g−1 of soil was described by the Weibull function. Four response variables (the reciproca

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11

Rossi, Davide, Clara Deambrogi, Tiziana Lischetti, et al. "Hypermethylation of SH2-Containing Phosphatase-1 (SHP-1) and Suppressor of Cytokine Signaling-1 and -3 (SOCS-1 and -3) in Philadelphia Negative Chronic Myeloproliferative Disorders (Ph-CMPD)." Blood 108, no. 11 (2006): 118. http://dx.doi.org/10.1182/blood.v108.11.118.118.

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Abstract A fraction of Ph- CMPD is characterized by JAK2F617F mutation leading to constitutive JAK-STAT activation. The negative regulators of cytokine signaling SHP-1, SOCS-1 and SOCS-3 have a crucial function in the negative regulation of JAK2 activation/phosphorylation in response to EPO, G-CSF and a subset of cytokines. SHP-1, SOCS-1 and SOCS-3 may be silenced by aberrant DNA methylation in human malignancies. Here we tested chronic phase Ph- CMPD and acute myeloid leukaemia (AML) from Ph- CMPD for aberrant DNA methylation of SHP-1, SOCS-1 and SOCS-3. The study was based on: i) 85 Ph- CMPD

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12

Silver, R. T., S. Lee, A. V. Jones, et al. "The frequency of the JAK2 V617F mutation in patients with polycythemia vera and its correlation with severity of disease." Journal of Clinical Oncology 24, no. 18_suppl (2006): 6587. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.6587.

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6587 Background: The frequency of the JAK2 V617F mutation in patients with polycythemia vera (PV) has ranged from approximately 65–97% in published reports from different institutions. Moreover, its expression has been variably correlated with certain aspects of the disease. Therefore, we quantified its frequency in patients from our institution, and also determined if its presence correlated with severity or duration of disease. Methods: We used stringent criteria to diagnose the disease PV. This included an initial CR51 red blood cell mass (RBCM) and I131 plasma volume. All causes of seconda

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13

Elnahass, Yasser, Hossam K. Mahmoud, Mervat Mattar, et al. "Triple Negative Myeloproliferative Neoplasms (MPNs) Patients Show Low MPN10 Score and Lower Grades of Bone Marrow Fibrosis." Blood 128, no. 22 (2016): 5477. http://dx.doi.org/10.1182/blood.v128.22.5477.5477.

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Abstract Introduction: The vast majority ofmyeloproliferative neoplasms (MPNs) patients are characterized by a molecular genetic background and by variable symptoms reflecting disease burden that may correlate with prognosis. Aim: To study the impact of triple negative status of driver gene mutations: Janus kinase 2 (JAK2), calreticulin (CALR) and myeloproliferative leukemia virus oncogene (MPL) on disease burden and its correlation with symptom severity (MPN10 score) and degree of bone marrow (BM) fibrosis in MPNs patients. Patients and Methods: MPN Symptom Assessment Form Total Symptom Score

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14

Gowin, Krisstina L., Amylou Constance Dueck, Srdan Verstovsek, et al. "The Clinical Phenotype of Patients with Primary Myelofibrosis, Polycythemia Vera, and Essential Thrombocytosis Whom Only Manifest WHO Grade 1 Fibrosis." Blood 124, no. 21 (2014): 3208. http://dx.doi.org/10.1182/blood.v124.21.3208.3208.

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Abstract Introduction: The clinical phenotype of patients with myeloproliferative neoplasms (MPNs) including primary myelofibrosis (PMF), polycythemia vera (PV), and essential thrombocytosis (ET) who manifest WHO grade 1 (on a 0-3 scale) for intramedullary fibrosis is poorly defined, and may represent MPN patients in a transitional state. We have specifically observed patients with existing PV and ET who manifest clinical progression towards a post PV/ET phenotype (IWG-MRT criteria) yet fail to progress to a 2+ marrow fibrosis. In contrast, the 2008 WHO definition of PMF does not require a min

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15

Müller, Ralf, Nicolas Hunzelmann, Vera Baur, et al. "Targeted Immunotherapy with Rituximab Leads to a Transient Alteration of the IgG Autoantibody Profile in Pemphigus Vulgaris." Dermatology Research and Practice 2010 (2010): 1–9. http://dx.doi.org/10.1155/2010/321950.

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In pemphigus vulgaris (PV), IgG autoantibodies against the ectodomain of desmoglein 3 (Dsg3) have been shown to be directly responsible for the loss of keratinocyteadhesion. The aim of the present study was to study the effect of the B cell depleting anti-CD20 monoclonal antibody, rituximab, on the profile of pathogenic IgG against distinct regions of the Dsg3 ectodomain in 22 PV patients who were followed up clinically and serologically by Dsg3 ELISA over 12-24 months. Prior to rituximab, all the 22 PV patients showed IgG against Dsg3 (Dsc3EC1-5). Specifically, 14/22 showed IgG reactivity aga

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16

De La Cruz, Jose Pedro, Sergio Del Río, Juan Antonio López-Villodres, Maria Auxiliadora Villalobos, Nuria Jebrouni, and Jose Antonio González-Correa. "Virgin olive oil administration improves the effect of aspirin on retinal vascular pattern in experimental diabetes mellitus." British Journal of Nutrition 104, no. 4 (2010): 560–65. http://dx.doi.org/10.1017/s0007114510000929.

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The aim of the present study is to evaluate the possible influence of virgin olive oil (VOO) on the effect of acetylsalicylic acid (ASA) in platelet aggregation, prostanoid and NO production and retinal vascular pattern in rats with experimental type 1-like diabetes. We used 100 male Wistar rats that were distributed into five groups: (1) non-diabetic rats (NDR); (2) untreated diabetic rats (DR); (3) DR treated with ASA (2 mg/kg per d per os (p.o.)); (4) DR treated with VOO (0·5 ml/kg per d p.o.); (5) DR treated with ASA plus VOO. The duration of diabetes was 3 months, and each treatment was a

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17

Peslin, R., M. Rotger, R. Farre, and D. Navajas. "Assessment of respiratory pressure-volume nonlinearity in rabbits during mechanical ventilation." Journal of Applied Physiology 80, no. 5 (1996): 1637–48. http://dx.doi.org/10.1152/jappl.1996.80.5.1637.

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The volume dependence of respiratory elastance makes it difficult to recognize actual changes in lung and chest wall elastic properties in artificially ventilated subjects. We have assessed in six anesthetized, tracheotomized, and paralyzed rabbits whether reliable information on the static pressure-volume (PV) curve could be obtained from recordings performed during step variations of the end-expiratory pressure without interrupting mechanical ventilation. Pressure and flow data recorded during 5- and 10-hPa positive-pressure steps were analyzed in the time domain with a nonlinear model featu

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18

Tefferi, Ayalew, Terra L. Lasho, Alexandra P. Wolanskyj, and Ruben A. Mesa. "Neutrophil PRV-1 expression across the chronic myeloproliferative disorders and in secondary or spurious polycythemia." Blood 103, no. 9 (2004): 3547–48. http://dx.doi.org/10.1182/blood-2003-10-3505.

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Abstract Recent studies have demonstrated neutrophil overexpression of the polycythemia rubra vera-1 (PRV-1) gene in polycythemia vera (PV) but not in secondary or spurious polycythemia (SP). To validate as well as expand upon this novel observation, we conducted a prospective study of 88 subjects: 30 with PV, 22 with SP, 14 with essential thrombocythemia (ET), 12 with myelofibrosis with myeloid metaplasia (MMM), and 10 controls. To minimize interstudy methodologic differences, we used a published real-time polymerase chain reaction (PCR)-based assay. The proportion of patients with increased

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19

Raff, Rebeka, Velimir Golub, and Jurica Perko. "Comparative Analysis of an Off-grid PV System for Different Types of Batteries." International journal of electrical and computer engineering systems 9, no. 1 (2018): 11–19. http://dx.doi.org/10.32985/ijeces.9.1.3.

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The aim of this paper is to find an optimal size of different components of an off-grid PV system in the HOMER software with different types of batteries (lead-acid batteries and lithium-ion batteries). The proposed model shows the optimal size of the off-grid PV system for a holiday cottage with regard to eligibility criteria for various types of batteries and the net present cost (NPC). The observed off-grid PV system consists of PV modules, a load, a converter and batteries and it is modelled in the HOMER software. The load is modelled with a daily load diagram for the holiday cottage. For

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Giona, Fiorina, Angela Amendola, Giovanna Palumbo, et al. "Inherited and Acquired Thrombophilic Abnormalities in Patients Aged <20 Years with Bcr-Abl Negative Chronic Myeloproliferative Disorders." Blood 112, no. 11 (2008): 5249. http://dx.doi.org/10.1182/blood.v112.11.5249.5249.

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Abstract Several associated thrombophilic abnormalities have been reported in adults with Bcr-Abl negative chronic myeloproliferative disorders (CMD), mostly in essential thrombocythemia (ET) and polycythemia vera (PV), while only sporadic data are available in younger patients (pts). In order to identify coagulation abnormalities in very young pts with a diagnosis of CMD, we evaluated different thrombophilic parameters in CMD pts aged &lt;20 years (yrs) at the time of diagnosis. Lupus anticoagulant (KCT and dRVVT), functional protein C (PC), free protein S (PS) antigen, functional antithr

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PRIETO M., ESPERANZA, DONICER MONTES V., RENÉ PATIÑO P., HEYMI CUELLO P., and CARMEN REGINO G. "Desempeño productivo y comportamiento ingestivo de terneros recibiendo diferente manejo alimenticio en un sistema doble propósito, departamento de Sucre, Colombia." Revista Colombiana de Ciencia Animal - RECIA 5, no. 2 (2013): 380. http://dx.doi.org/10.24188/recia.v5.n2.2013.450.

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El objetivo de la investigación fue evaluar el desempeño productivo y el comportamiento ingestivo de terneros lactantes recibiendo diferentes tipos de manejo alimenticio, en un sistema doble propósito del departamento de Sucre. Se utilizaron 34 terneros lactantes. Al momento de iniciar la fase experimental se seleccionaron al azar veinte terneros menores de un mes de edad (20 días) con 39,4 kg (±7,8) de peso, y catorce terneros mayores de 4 meses (112 días) con 66,5 kg (±9,8) de peso. En los animales de menor edad se aplicaron los siguientes tratamientos: T1 (Ocho horas diarias con la vaca + P

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22

Karunakaran, Smitha, Ananya Chowdhury, Flavio Donato, Charles Quairiaux, Christoph M. Michel, and Pico Caroni. "Author Correction: PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation." Nature Neuroscience 21, no. 9 (2018): 1290. http://dx.doi.org/10.1038/s41593-018-0179-0.

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Tefferi, Ayalew, Shireen Sirhan, Terra L. Lasho, et al. "The Clinical and PRV-1 Expression Phenotype of Wild-Type, Heterozygous, and Homozygous JAK2 V617F in Polycythemia Vera." Blood 106, no. 11 (2005): 255. http://dx.doi.org/10.1182/blood.v106.11.255.255.

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Abstract BACKGROUND. Several studies have recently reported on the occurrence of a JAK2 V617F mutation in myeloid cells from the majority of patients with polycythemia vera (PV). The clinical relevance of this novel observation is currently under study. Similarly, there is limited information regarding the correlation of JAK2 V617F mutational status and neutrophil PRV-1 transcript level in PV, secondary polycythemia (SP) and other myeloproliferative disorders (MPD). METHODS. In a single institutional study, mutation screening for JAK2 V617F was performed in DNA derived from archived blood gran

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24

Benevolo, Giulia, Maura Nicolosi, Francesca Palandri, et al. "Bone Marrow Reticulin Fibrosis in 579 Patients with Polycythemia Vera and Essential Thrombocythemia: Effect on Clinical Outcome." Blood 128, no. 22 (2016): 3130. http://dx.doi.org/10.1182/blood.v128.22.3130.3130.

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Abstract Background: Prognostic value of bone marrow (BM) fibrosis grading in myeloproliferative neoplasm (MPN) is still debated. Polycythemia Vera (PV) and Essential Thrombocythemia (ET) are long term outcome MPN; however, they could evolve to adverse secondary myelofibrosis-MF or acute leukemia-AL. Aims and Methods: We retrospectively analyzeda cohort of 579 World Health Organization-defined PV (n=180) and ET (n=399) patients, and examined the prevalence and prognostic relevance of BM reticulin fibrosis. All patients were diagnosed between 1990 and 2013 and were recruited in Turin (n= 436) a

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Zaleski, Piotr, Marek Wojciechowski, and Andrzej Piekarowicz. "The role of Dam methylation in phase variation of Haemophilus influenzae genes involved in defence against phage infection." Microbiology 151, no. 10 (2005): 3361–69. http://dx.doi.org/10.1099/mic.0.28184-0.

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Haemophilus influenzae uses phase variation (PV) to modulate the activity of its defence systems against phage infection. The PV of the restriction–modification (R-M) system HindI, the main defence system against phage infection and incoming chromosomal and phage DNA in H. influenzae Rd, is driven by changes of the pentanucleotide repeat tract within the coding sequence of the hsdM gene and is influenced by lack of Dam methylation. Phase-variable resistance/sensitivity to phage infection correlates with changes in lipooligosaccharide (LOS) structure and occurs by slippage of tetranucleotide re

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Yassin, Mohamed A., Hanadi Rafii El-Ayoubi, and Nader Al-Dewik. "Using Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) to Evaluate Quality of Life for MPN Patients in Qatar." Blood 120, no. 21 (2012): 5069. http://dx.doi.org/10.1182/blood.v120.21.5069.5069.

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Abstract Abstract 5069 Background: Myeloproliferative neoplasms (MPNs), that is, essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF), are a group of MPNs that can lead to significant rates of morbidity and mortality among affected patients. Specifically, patients in the early stages of these illnesses (ET, PV, and early MF) can be predisposed to thrombohemorrhagic events and vascular complications. Long-term complications of MPNs (either primary MF or MF arising from an antecedent ET or PV) can include progressive cytopenias, constitutional symptoms, cachexia and wei

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Paul, Damasen Ikwaba. "Theoretical and Experimental Optical Evaluation and Comparison of Symmetric 2D CPC and V-Trough Collector for Photovoltaic Applications." International Journal of Photoenergy 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/693463.

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This paper presents theoretical and experimental optical evaluation and comparison of symmetric Compound Parabolic Concentrator (CPC) and V-trough collector. For direct optical properties comparison, both concentrators were deliberately designed to have the same geometrical concentration ratio (1.96), aperture area, absorber area, and maximum concentrator length. The theoretical optical evaluation of the CPC and V-trough collector was carried out using a ray-trace technique while the experimental optical efficiency and solar energy flux distributions were analysed using an isolated cell PV mod

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Van Bressem, Marie-Françoise, Patricia Cassonnet, Annabel Rector, et al. "Genital warts in Burmeister's porpoises: characterization of Phocoena spinipinnis papillomavirus type 1 (PsPV-1) and evidence for a second, distantly related PsPV." Journal of General Virology 88, no. 7 (2007): 1928–33. http://dx.doi.org/10.1099/vir.0.82694-0.

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We identified sequences from two distantly related papillomaviruses in genital warts from two Burmeister's porpoises, including a PV antigen-positive specimen, and characterized Phocoena spinipinnis papillomavirus type 1 (PsPV-1). The PsPV-1 genome comprises 7879 nt and presents unusual features. It lacks an E7, an E8 and a bona fide E5 open reading frame (ORF) and has a large E6 ORF. PsPV-1 L1 ORF showed the highest percentage of nucleotide identity (54–55 %) with human papillomavirus type 5, bovine papillomavirus type 3 (BPV-3) and Tursiops truncatus papillomavirus type 2 (TtPV-2). This warr

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Goto, Masaki, Kazunobu Okazaki, Yoshi-ichiro Kamijo, et al. "Protein and carbohydrate supplementation during 5-day aerobic training enhanced plasma volume expansion and thermoregulatory adaptation in young men." Journal of Applied Physiology 109, no. 4 (2010): 1247–55. http://dx.doi.org/10.1152/japplphysiol.00577.2010.

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We examined whether protein and carbohydrate (CHO) supplementation during 5-day training enhanced plasma volume (PV) expansion and thermoregulatory and cardiovascular adaptations in young men. Eighteen men [age 23 ± 4 (SD) yr] were divided into two groups according to supplements: placebo (CNT: 0.93 kcal/kg, 0.00 g protein/kg, n = 9) and protein and CHO (Pro-CHO: 3.6 kcal/kg, 0.36 protein/kg, n = 9). Subjects in both groups performed a cycling exercise at 70% peak oxygen consumption rate (V̇o2peak), 30 min/day, for 5 consecutive days at 30°C ambient temperature and 50% relative humidity and to

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Brienza, N., T. Ayuse, J. P. Revelly, C. P. O'Donnell, and J. L. Robotham. "Effects of endotoxin on isolated porcine liver: pressure-flow analysis." Journal of Applied Physiology 78, no. 3 (1995): 784–92. http://dx.doi.org/10.1152/jappl.1995.78.3.784.

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The peripheral vascular response to sepsis is characterized by a vasodilatation of the systemic arterial vessels. Pulmonary hypertension with an increase in resistance and back pressure to flow defined by pressure-flow (P-Q) relationships has been reported in experimental sepsis. We hypothesized that endotoxin can induce differential alterations in resistance and back pressure to flow in the liver venous and arterial beds. Ninety minutes after endotoxin administration in intact anesthetized pigs (n = 8), the liver was vascularly isolated and perfused. Steady-state P-Q relationships in both the

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Bizeau, Michael E., Jeffrey S. Thresher, and Michael J. Pagliassotti. "Sucrose diets increase glucose-6-phosphatase and glucose release and decrease glucokinase in hepatocytes." Journal of Applied Physiology 91, no. 5 (2001): 2041–46. http://dx.doi.org/10.1152/jappl.2001.91.5.2041.

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A high-sucrose diet (SU) decreases insulin action in the liver (Pagliassotti MJ, Shahrokhi KA, and Moscarello M. Am J Physiol Regulatory Integrative Comp Physiol 266: R1637–R1644, 1994). The present study was conducted to characterize the effect of SU on glucagon action in isolated periportal (PP) and perivenous (PV) hepatocytes by measuring glucagon-stimulated glycogenolysis and glucose release. Male rats were fed a SU (68% sucrose) or starch diet (ST, 68% starch) for 1 wk, and hepatocytes were isolated from PP or PV regions ( n = 4/diet/cell population). Hepatocytes were incubated for 1 h in

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Moliterno, Alison R., Donna M. Williams, Ophelia Rogers, Mary Ann Isaacs, and Jerry L. Spivak. "Disease Burden in the Chronic Myeloproliferative Disorders Correlates with the Stem Level of JAK2 V617F Expression." Blood 108, no. 11 (2006): 668. http://dx.doi.org/10.1182/blood.v108.11.668.668.

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Abstract The chronic myeloproliferative disorders (MPD), polycythemia vera (PV), essential thrombocytosis (ET) and idiopathic myelofibrosis (IMF) differ phenotypically but are linked by a common genetic lesion, JAK2V617F. Additional molecular lesions, host genetics or stem cell level of involvement are possible explanations for the differing myeloproliferative phenotypes associated with similar degrees of JAK2V617F. In this study, we examined the correlation between the stem cell level of JAK2V617F involvement and disease phenotype. The study population consisted of 35 PV, 14 ET and 7 IMF pati

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Mesa, Ruben, Carole B. Miller, Maureen Thyne, et al. "Impact of Myeloproliferative Neoplasms (MPNs) on Patients’ Overall Health and Productivity: Results from the MPN LANDMARK SURVEY in the United States." Blood 124, no. 21 (2014): 3183. http://dx.doi.org/10.1182/blood.v124.21.3183.3183.

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Abstract Background: Myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET), are chronic MPNs associated with a broad array of symptoms that may negatively impact patients’ quality of life (QoL). To enhance patient care, it is important to have a current and clear understanding of how MPNs affect the overall health and daily lives of patients. The MPN LANDMARK SURVEY was developed to examine patients’ perceptions of these MPNs related to disease burden, QoL, productivity, and activities of daily living (ADLs). Methods: Eligible patients diagnosed with an MPN were recrui

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Domenech, Bruno, Gema Calleja, and Jordi Olivella. "Residential Photovoltaic Profitability with Storage under the New Spanish Regulation: A Multi-Scenario Analysis." Energies 14, no. 7 (2021): 1987. http://dx.doi.org/10.3390/en14071987.

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In recent years, solar price drops and regulations have helped residential users to invest in grid-connected photovoltaic (PV) facilities. In Spain, a novel law promotes self-consumption by discounting electricity fed into the grid from the utility bill. However, the performance of PV-based facilities depends on diverse factors. The contribution of this paper is to evaluate the techno-economic performance of such installations for different considerations linked to the Spanish law. A simulation model is used to examine different representative cities, load profiles and alternative objectives:

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Hirono, Seiko, Masaji Tani, Manabu Kawai, et al. "Prognostic factors of pancreatic neck cancer." Journal of Clinical Oncology 32, no. 3_suppl (2014): 355. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.355.

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355 Background: Pancreatic neck cancer is surrounded by common hepatic artery (CHA), gastroduodenal artery (GDA) and portal vein (PV), and easily invades nerve plexus around main arteries, such as CHA, celiac trunk, and superior mesenteric artery (SMA). Therefore, the resectablity of pancreatic neck cancer is low, and the biological behaviors have been unclear. In this study, we reviewed 59 resected pancreatic neck cancer cases to identify the prognostic factors. Methods: From 2000 to 2012, 305 patients with pancreatic cancer underwent surgical resection, and in 59 patients (19%) among them wi

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Cheng, Yi-Chi, Marcos E. Duarte, and Sung Woo Kim. "179 Efficacy and safety of amino acids with biomass for growth and health of newly-weaned pigs." Journal of Animal Science 98, Supplement_3 (2020): 77. http://dx.doi.org/10.1093/jas/skaa054.138.

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Abstract The objective was to test the efficacy of L-Thr or L-Val with biomass (ThrPro or ValPro; CJ BIO, Fort Dodge, IA) on growth performance and health compared with L-Thr or L-Val (purified) in newly-weaned pigs. There were 9 dietary treatments based on NRC (2012) requirements: NC (basal diet meeting 70% of requirements for SID Thr and Val); 4 treatments based on basal diet meeting 95% of requirements: LT (with L-Thr), LV (with L-Val), PT (with ThrPro), and PV (with ValPro); HLT (fivefold L-Thr in LT), HLV (fivefold L-Val in LV), HPT (fivefold ThrPro in PT), and HPV (fivefold ValPro in PV)

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Ramalho, Ricardo Pimentel, Marcelo de Andrade Ferreira, Antonia Sherlânea Chaves Véras, Luiz Evandro de Lima, and Vitória Régia Ramos de Albuquerque Rocha. "Substituição do milho pela raspa de mandioca em dietas para vacas primíparas em lactação." Revista Brasileira de Zootecnia 35, no. 3 suppl (2006): 1221–27. http://dx.doi.org/10.1590/s1516-35982006000400037.

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Com o objetivo de avaliar a influência de níveis de substituição do milho moído pela raspa de mandioca no desempenho dos animais, no consumo e na digestibilidade dos nutrientes de dietas à base de palma forrageira (Opuntia ficus indica, Mill) e silagem de sorgo, cinco vacas primíparas da raça Holandesa (60±15 dias em lactação e 448 kg de PV inicial) foram distribuídas em um único quadrado latino (5 x 5). A raspa de mandioca substituiu 0, 25, 50, 75 e 100% do milho moído nas dietas. Os consumos e a digestibilidade de MS (em kg/dia, % do PV, g/kg0,75 do PV), MO, PB, EE, CNF, CHOT, FDA, FDN e NDT

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Meggendorfer, Manja, Tamara Alpermann, Claudia Haferlach, Wolfgang Kern, Susanne Schnittger, and Torsten Haferlach. "Comprehensive Molecular Analyses of BCR-ABL1 Negative MPN Show That PMF Is Genetically Much More Heterogeneous Than ET and PV." Blood 124, no. 21 (2014): 3224. http://dx.doi.org/10.1182/blood.v124.21.3224.3224.

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Abstract Introduction: In the WHO classification (2008) JAK2 and MPL mutations are major criteria for the diagnosis of myeloproliferative neoplasms (MPN): polycythemia vera (PV), primary myelofibrosis (PMF), and essential thrombocythemia (ET). Cytogenetic aberrations are rare in these entities. Although the prognostic impact of JAK2 mutations beside some other gene mutations has been shown in PMF patients, the driving events for establishing accelerated phase or blast crises are unknown. In recent years, novel molecular markers such as ASXL1, SRSF2, and CALR were identified and PMF was investi

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Kiladjian, Jean-Jacques, Sabrina Dupont, Bruno Cassinat та ін. "Can Peg-Interferon (IFN) α-2a Eradicate JAK2V617F-Positive Bone Marrow Progenitors in Polycythemia Vera (PV)?" Blood 112, № 11 (2008): 659. http://dx.doi.org/10.1182/blood.v112.11.659.659.

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Abstract Background: In a phase 2 trial of peg-IFN-alpha-2a, we observed disappearance of JAK2V617F in peripheral blood (PB) granulocytes in 7/29 (24%) treated PV patients using an allele specific PCR assay with a 1% sensitivity (Blood online, July 23, 2008). IFN-alpha has been shown to induce cytogenetic remission or reversion to polyclonal hematopoiesis by studies of occasional patients. The 7 cases of complete molecular remissions (CMR) we identified by V617F monitoring constitute the first cohort of patients with measurable reduction of the PV clone. The study of this cohort may allow answ

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Jinming, Song, Mohammad Omar Hussaini, Haipeng Shao, et al. "Refining Triage to Polycythaemia Vera or Primary Myelofibrosis Based on Targeted Molecular Profiling By Clinical Next Generation Sequencing." Blood 126, no. 23 (2015): 4076. http://dx.doi.org/10.1182/blood.v126.23.4076.4076.

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Abstract Background: Primary myelofibrosis (PMF) and polycythemia vera (PV) are myeloproliferative neoplasms (MPN) that can both share a similar bone marrow morphology with panmyelosis and fibrosis, posing a diagnostic challenge, particularly when the differential is between cellular phase of PMF and PV, or fibrotic PMF and post-PV myelofibrosis. Despite advances in genomic analysis, limited information is known regarding their differences in genetic profile/signature. It has been well known that constitutive tyrosine kinase activation due to JAK2 V617F mutation is seen in both PV and PMF. MPL

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Stickel, Juliane S., Daniel J. Kowalewski, Steffen Koschmieder, et al. "HLA Ligandome Analysis in Primary Polycythemia Vera (PV) Samples Shows No Tumor-Association of Naturally Presented JAK2 Ligands but Reveals a Vast Array of Novel PV-Associated HLA Ligands." Blood 124, no. 21 (2014): 4581. http://dx.doi.org/10.1182/blood.v124.21.4581.4581.

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Abstract Polycythemia vera (PV) is a myeloproliferative disorder mainly driven by the JAK2V617F mutant kinase. Except allogeneic stem cell transplantation, the current standard therapies, including novel therapies aiming for specific inhibition of JAK2 that are presently under investigation, do not offer a chance for cure. Of note, clear clinical benefits of unspecific immunotherapy with pegylated IFN-α suggest that PV might also be targeted by specific peptide based vaccination. Here we aimed to identify tumor associated HLA ligands of PV with special focus on peptides derived from JAK2. Ther

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Bang, Soo-Mee, Eun Mi Nam, Jeong Yeal Ahn, et al. "Diagnostic Usefulness of JAK2 Mutation in Manistest or Latent Polycythemia Vera and Secondary Polycythemia." Blood 108, no. 11 (2006): 4901. http://dx.doi.org/10.1182/blood.v108.11.4901.4901.

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Abstract Backgrounds: The discovery of Janus kinase 2 (JAK2) mutation make it easy to diagnose polycythemia vera (PV) in which the prevalence of this mutation is reported up to 96%. The latent PV is defined in patients who show the lower hemoglobin than WHO criteria at the time of diagnosis without any cause of secondary erythrocytosis; 17~18.5g/dL in male and 15 ~16.5g/dL in female. We investigated the mutational status of JAK2 in polycythemia vera either of latent or manifest type and secondary polycythemia. Methods : We reviewed the clinical records of 182 patients from 8 centers, who under

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Fonseca, Jose Pedro, Sunhee Oh, Clarissa Boschiero, Bonnie Watson, David Huhman, and Kirankumar S. Mysore. "The Arabidopsis Iron-Sulfur (Fe-S) Cluster Gene MFDX1 Plays a Role in Host and Nonhost Disease Resistance by Accumulation of Defense-Related Metabolites." International Journal of Molecular Sciences 22, no. 13 (2021): 7147. http://dx.doi.org/10.3390/ijms22137147.

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Until recently, genes from the iron-sulfur (Fe-S) cluster pathway were not known to have a role in plant disease resistance. The Nitrogen Fixation S (NIFS)-like 1 (NFS1) and Mitochondrial Ferredoxin-1 (MFDX1) genes are part of a set of 27 Fe-S cluster genes induced after infection with host and nonhost pathogens in Arabidopsis. A role for AtNFS1 in plant immunity was recently demonstrated. In this work, we showed that MFDX1 is also involved in plant defense. More specifically, Arabidopsis mfdx1 mutants were compromised for nonhost resistance against Pseudomonas syringae pv. tabaci, and showed

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Keith, Lisa Wolfson, Carol Boyd, Noel T. Keen, and J. E. Partridge. "Comparison of avrD alleles from Pseudomonas syringae pv. glycinea." Molecular Plant-Microbe Interactions® 10, no. 3 (1997): 416–22. http://dx.doi.org/10.1094/mpmi.1997.10.3.416.

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Avirulence gene D alleles resided on indigenous plasmids in races 0, 2, 3, 4, 5, and 6 of Pseudomonas syringae pv. glycinea (Psg), but the allele in race 1 appeared to be chromosomal. These were all nonfunctional avirulence genes because they neither induced the avirulence phenotype on Rpg4 soybean cultivars nor directed the production of syringolide elicitors when expressed in Escherichia coli cells. The predicted proteins encoded by the seven Psg avrD genes were very similar to that of a functional class II allele from P. syringae pv. phaseolicola G50 race 2, but contained mutations collecti

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Billiet, Johan, Sofie Tilleman, Jan Van Droogenbroeck, et al. "Diagnostic Utility of PRV-1 mRNA Quantification in Polycythemia Vera and Essential Thrombocythemia." Blood 104, no. 11 (2004): 4751. http://dx.doi.org/10.1182/blood.v104.11.4751.4751.

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Abstract In recent reports, granulocyte PRV-1 mRNA has been shown to be over-expressed in the majority of polycythemia vera (PV) patients and with a variable frequency in essential thrombocythemia (ET) patients. Here we evaluate PRV-1 mRNA quantification in the diagnosis of PV and ET. Following patients were included in the study: 23 PV patients; 5 secondary erythrocytosis (SE) cases, 4 by lung disease and 1 by a hemoglobinopathy (Hb San Diego); 4 relative erythrocytosis (RE) cases; and 13 ET patients. PV and ET diagnosis was made according to the WHO criteria. At time of sampling 43% of PV pa

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Savolainen-Kopra, Carita, Elena Samoilovich, Heidi Kahelin, Anna-Kaisa Hiekka, Tapani Hovi, and Merja Roivainen. "Comparison of poliovirus recombinants: accumulation of point mutations provides further advantages." Journal of General Virology 90, no. 8 (2009): 1859–68. http://dx.doi.org/10.1099/vir.0.010942-0.

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The roles of recombination and accumulation of point mutations in the origin of new poliovirus (PV) characteristics have been hypothesized, but it is not known which are essential to evolution. We studied phenotypic differences between recombinant PV strains isolated from successive stool specimens of an oral PV vaccine recipient. The studied strains included three PV2/PV1 recombinants with increasing numbers of mutations in the VP1 gene, two of the three with an amino acid change I→T in the DE-loop of VP1, their putative PV1 parent and strains Sabin 1 and 2. Growth of these viruses was examin

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Hidalgo Lopez, Juliana, Rashmi Kanagal-Shamanna, Rafael Rojas Sáurez, and Carlos E. Bueso-Ramos. "Myeloid Blast Phase of PV Can be Differentiated from De Novo AML with JAK2 Mutation By Its Adverse Cytogenetics and Distinct Molecular Profile." Blood 132, Supplement 1 (2018): 4308. http://dx.doi.org/10.1182/blood-2018-99-117615.

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Abstract Introduction: Blast phase (BP) of polycythemia Vera (PV) develops in 10-15% of cases at 10 years. Myeloid BP frequently presents with myelodysplasia (88%) and is associated with poor prognosis, median OS of 4 months. De novo JAK2 mutated (mut) AML usually presents with multilineage dysplasia and median OS of 14 months. We hypothesize that cytogenetics (CG) and molecular profile can aid in the distinction of these different entities with similar clinical phenotype. We compared the molecular profile by targeted next-generation sequencing (NGS) of de novo JAK2mut AML and JAK2mut BP of PV

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Gau, Jyh-Pyng, Chih-Cheng Chen, Chia-Jen Liu, et al. "The 46/1 Haplotype Frequency Is Not Increased in Patients of Essential Thrombocythemia with CALR Mutations." Blood 124, no. 21 (2014): 5204. http://dx.doi.org/10.1182/blood.v124.21.5204.5204.

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Abstract Purpose The frequency of 46/1 haplotype in myeloproliferative neoplasms (MPN) patients with JAK2V617F mutation or CALR mutations were determined to explore their association. Patients and Methods MPN patients were diagnosed based on WHO criteria. Allele-specific PCR and PCR with direct sequencing were utilized to identify various mutations in MPNs and genotype of the 46/1 haplotype-associated SNP (C nucleotide at rs12343867). Results From Oct 2011 to Aug 2014, 187 cases of MPN with diagnosis of polycythemia vera (PV) and essential thrombocythemia (ET) were recruited for study after ob

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Vener, Claudia, Umberto Gianelli, Paola Rafaniello Raviele, et al. "Immunohistochemical Expression of Vascular Endothelial Growth Factor Correlates with Microvessel Density in Ph− Chronic Myeloproliferative Disorders." Blood 108, no. 11 (2006): 2698. http://dx.doi.org/10.1182/blood.v108.11.2698.2698.

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Abstract There is increasing evidence that neovascularization may play an important role in hematological malignancies (particularly lymphomas, acute leukemia and myelodysplastic syndromes), but only a few studies have been performed in Ph− chronic myeloproliferative disorders (CMPDs). Increased angiogenesis has been reported in chronic idiopathic myelofibrosis (CIMF), whereas high serum levels of vascular endothelial growth factor (VEGF) have been described in Ph− CMPDs. These findings have led to the use of new therapeutic approaches aimed at directly targeting endothelial cells or VEGF. The

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Rossi, Davide, Clara Deambrogi, Daniela Capello, et al. "JAK2V617F Mutation in Leukaemic Transformation of Philadelphia Negative Chronic Myeloproliferative Disorders." Blood 108, no. 11 (2006): 3605. http://dx.doi.org/10.1182/blood.v108.11.3605.3605.

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Abstract The natural history of Philadelphia negative chronic myeloproliferative disorders (Ph- CMPD) is characterized by a chronic phase that, in a fraction of cases, may progress to acute leukaemia. The JAK2V617F mutation occurs in 70–90% of polycythaemia vera (PV) and 30–50% essential thrombocythaemia (ET) and idiopathic myelofibrosis (IMF). The aim of this study was to verify the prevalence of JAK2V617F mutation in acute myeloid leukaemia (AML) evolved from Ph- CMPD. Bone marrow samples were derived from 5 PV, 10 ET and 5 IMF patients at the time of transformation to AML. In four cases, th

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