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Journal articles on the topic 'PVP K30'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Shete, Nikhil Arun, Vishwajeet M. Swami, Avinash Chaudhari, and Prachi N. Khabiya. "A Design of Experiment Approach for Optimization and Characterization of Clarithromycin Ternary System Using Spray Drying." Journal of Drug Delivery and Therapeutics 10, no. 3-s (2020): 211–20. http://dx.doi.org/10.22270/jddt.v10i3-s.4185.

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The aim of present work was to characterize Clarithromycin (CLT), Polyvinyl pyrrolidone K30 (PVP K30) and Hydroxypropyl β-cyclodextrin (HPB) ternary system so as to check the effect of complexation on solubility of CLT. Physical mixtures of a drug and polymers in several weight ratios (1:1, 1:2) were prepared to check the effect of individual polymers on solubility of CLT. Spray drying method was accustomed investigate the combined effect of PVP K30 and HPB on Drug release (DR), Dissolution efficiency (DE) and mean dissolution time (MDT) of CLT. For the preparation and optimization of ternary

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2

Shaikh, Amir A., Praveen D. Chaudhari, and Sagar S. Holkar. "A DESIGN OF EXPERIMENT APPROACH FOR OPTIMIZATION AND CHARACTERIZATION OF ETODOLAC TERNARY SYSTEM USING SPRAY DRYING." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 2 (2017): 233. http://dx.doi.org/10.22159/ijpps.2017v9i2.16087.

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<p><strong>Objective: </strong>The objective of the present investigation was to prepare and characterize Etodolac (ETO), Polyvinyl pyrrolidone K30 (PVP K30) and Hydroxypropyl β-cyclodextrin (HPB) ternary system in order to study the effect of complexation on solubility of ETO.</p><p><strong>Methods: </strong>Physical mixtures of a drug and polymers in different weight ratios (1:1, 1:2, 1:4) were prepared to study the effect of individual polymers on solubility of ETO. Spray drying method was used to investigate the combined effect of PVP K30 and HPB o

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3

Maheswari, K. M., Pavan Kumar Devineni, Sravanthi Deekonda, Salma Shaik, Naga Pravallika Uppala, and Buchi N. Nalluri. "Development and Evaluation of Mouth Dissolving Films of Amlodipine Besylate for Enhanced Therapeutic Efficacy." Journal of Pharmaceutics 2014 (March 27, 2014): 1–10. http://dx.doi.org/10.1155/2014/520949.

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The present investigation was undertaken with an objective of formulating mouth dissolving films (MDFs) of Amlodipine Besylate (AMLO) to enhance convenience and compliance of the elderly and pediatric patients for better therapeutic efficacy. Film formers like hydroxy propyl methyl cellulose (HPMC) and methyl cellulose (MC) along with film modifiers like poly vinyl pyrrolidone K30 (PVP K30), and sodium lauryl sulphate (SLS) as solubilizing agents were evaluated. The prepared MDFs were evaluated for in vitro dissolution characteristics, in vitro disintegration time, and their physicomechanical

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4

Lu, Min, Wei Wei, Wenhao Xu, Nikolay E. Polyakov, Alexandr V. Dushkin, and Weike Su. "Preparation of DNC Solid Dispersion by a Mechanochemical Method with Glycyrrhizic Acid and Polyvinylpyrrolidone to Enhance Bioavailability and Activity." Polymers 14, no. 10 (2022): 2037. http://dx.doi.org/10.3390/polym14102037.

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To exploit aqueous-soluble formulation and improve the anticoccidial activity of 4,4′-dinitrocarbanilide (DNC, active component of nicarbazin), this paper prepared DNC/GA/PVP K30 solid dispersion (SD) with glycyrrhizic acid (GA) and polyvinylpyrrolidone (PVP) K30 by a mechanical ball milling method without using any organic solvent. Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, and scanning electron microscopy were used for the solid state characterization. High performance liquid chromatography, critical micelle concentration, particle characte

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5

Wang, Jie Liang, Ai Juan Gu, and Guo Zheng Liang. "Modification of Bisphenol A Dicyanate Ester Resin with Poly Vinyl Pyrrolidone (K30)." Advanced Materials Research 217-218 (March 2011): 1497–503. http://dx.doi.org/10.4028/www.scientific.net/amr.217-218.1497.

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Poly vinyl pyrrolidone (PVP(K30)) / Bisphenol A Dicyanate ester (BADCy) blends were fabricated to increase the toughness of BADCy by blending processing in this paper. Curing parameters were determined by gelation time curves and differential scanning calorimetry (DSC) of the systems. Fourier transform infrared spectrometry (FTIR) and DSC data were employed to show the curing behavior and kinetics of the systems. Mechanical properties of the cured resin had been improved rapidly with the increasing of PVP(K30) at low mass fraction, but would decrease when mass fractions of PVP(K30) were higher

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6

Noval, Noval, and Rosyifa Rosyifa. "SOLID DISPERSION FOR INCREASING DISSOLUTION RATE OF SODIUM DICLOFENAC WITH VARIATIONS OF POLYVINYL PYRROLIDONE K30." Journal of Pharmaceutical Care Anwar Medika 3, no. 2 (2021): 86–98. http://dx.doi.org/10.36932/jpcam.v3i2.46.

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Diclofenac sodium is included in class II category based on biopharmaceutics classification system (BCS), sodium diclofenac has low solubility and high permeability. Low solubility will affect absorption of drugs in body because rate of dissolution will decrease. PVP K30 is inert carrier that dissolves easily in water and can affect solubility of an active drug substance. To know solid dispersion system increasing dissolution rate of sodium diclofenac by adding variations concentration of PVP K30. Solid dispersion uses solvent method with variations concentration of PVP K30 1:3, 1:5, 1:7 and 1

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7

Kotia, Ankit, Sunil More, Aman Yadav, et al. "Rheological Properties and Its Effect on the Lubrication Mechanism of PVP K30 and PVP 40-50 G as Artificial Synovial Fluids." Inventions 6, no. 4 (2021): 61. http://dx.doi.org/10.3390/inventions6040061.

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The effect of polyvinylpyrrolidone (PVP) on the rheological properties of joint prostheses is still unclear, despite its good lubricity and biocompatibility. In the present work, PVP K30 and PVP 40-50 G solutions at different concentrations were analyzed for rheological and lubrication properties. The rheological properties of the samples were measured at a shear rate range of 0–1800 s−1 (advanced air bearing rheometer Bohlin Gemini 2 and Plate MCR 72/92 rheometer for PVP30 and PVP 40-50 G, respectively). It was found that both the viscosity and shear stress of the samples reduced with a shear

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8

Noval, Noval, and Rosyifa Rosyifa. "Dispersi Padat untuk Peningkatan Laju Disolusi Natrium Diklofenak dengan Variasi Konsentrasi Polivinil Pirolidon K30." Jurnal Surya Medika 6, no. 2 (2021): 94–101. http://dx.doi.org/10.33084/jsm.v6i2.2125.

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Diclofenac sodium is included in the class II category based on the biopharmaceutics classification system (BCS), sodium diclofenac has low solubility and high permeability. Low solubility will affect the absorption of drugs in the body because the rate of dissolution will decrease. Polyvinyl Pyrrolidone (PVP) K30 is an inert carrier that dissolves easily in water and can affect the solubility of an active drug substance. To know solid dispersion system increasing dissolution rate of sodium diclofenac by adding variations concentration of PVP K30. Solid dispersion uses a solvent method with va

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9

Liu, Luan, Jin Hu, Yu Tian Wang, Kai Jun Wang, and Lin Su. "Preparation of Sub-Micrometre Size Platinum Particles via Chemical Reduction of Hexachloroplatinic Acid in Aqueous Solution." Advanced Materials Research 1058 (November 2014): 48–51. http://dx.doi.org/10.4028/www.scientific.net/amr.1058.48.

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The sub-micrometre size platinum particles via chemical reduction of hexachloroplatinic acid in aqueous solution was investigated by UV-Visible Spectroscopy, Transmission Electron Microscopy, X-ray diffraction and FTIR Spectroscopy. Hydrazine hydrate was used as the reducing agent, and polyvinylpyrrolidone (PVP-K30) was used for stabilizing the particles. By varying the amount of PVP-K30 the average diameter of the platinum particles could be adjusted. The TEM and XRD results revealed that the final sub-micrometre size Pt particles were the result of an aggregation of small (~5 nm) nanoparticl

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10

Zhu, Wei-Feng, Lin Zhu, Zhe Li, et al. "The Novel Use of PVP K30 as Templating Agent in Production of Porous Lactose." Pharmaceutics 13, no. 6 (2021): 814. http://dx.doi.org/10.3390/pharmaceutics13060814.

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It is necessary to prepare porous lactose in order to improve the dissolution behavior of insoluble active ingredient. In this study, polyvinylpyrrolidone K30 (PVP K30) was firstly utilized as a templating agent with different use levels in preparing porous lactose. Then, the physical properties were profoundly characterized. Finally, the porous lactose was also employed as a health functional food/drug carrier to explore the effect on the dissolution behavior of curcumin. The results confirmed that (i) porous lactose was successfully prepared using PVP K30 as templating agent; (ii) PVP K30 si

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Nur, Amran, Ermalyanti Fiskia, and Bambang Tjiroso. "Evaluation Profile In Vitro Release Gastroretentive High Density Tablet Theophylline Using Sodium Alginate and PVP." E3S Web of Conferences 328 (2021): 01001. http://dx.doi.org/10.1051/e3sconf/202132801001.

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The high-density gastroretentive dosage forms was made a high-density theophylline tablets 250 mg by wet granulation method in three formulas with combine the polymer concentration. The polymer used sodium alginate and PVP K30, where the 1st formula ratio of sodium alginate: PVP K30 (18.75%: 5%), the 2nd formula ratio of sodium alginate: PVP K30 (18.75%: 2, 5%) and 3th formula ratio of sodium alginate: PVP K30 (12.5%: 2.5%). The third formula were evaluated with weight uniformity test, size uniformity test, hardness test, drug content test, in vitro release test, as well as the determination o

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Yadav, Pankajkumar. "Abstract 10 — Enhancing Dissolution Efficiency of Ketoprofen, A Rheumatoid Arthritis Pain Management Drug, through Solid Dispersion Formulation." Journal of Clinical Rheumatology and Immunology 23, Supp01 (2023): 29. http://dx.doi.org/10.1142/s2661341723740267.

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Background Ketoprofen (KPN) is commonly prescribed drug to alleviate pain related with rheumatoid arthritis (RA). However, KETO belongs to the BCS class-II category, characterized by poor water solubility, resulting in less dissolution capability leading to limited systemic absorption. Purpose of this study was to increase aqueous solubility as well as rate of dissolution of KPN using solid-dispersion technique. Methods Two different hydrophilic carriers, D-mannitol and polyvinylpyrrolidone K30 (PVP K30) and, were utilized, in varying ratios with the drug, to formulate solid dispersions. Knead

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13

Swarup, Pallavi, and Gopal Prasad Agrawal. "Development of hesperidin solid dispersion for improved solubility and dissolution using mannitol and PVP K30 as carriers." Journal of Applied Pharmaceutical Research 12, no. 6 (2024): 192–202. https://doi.org/10.69857/joapr.v12i6.723.

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Background: Despite its six-hour half-life, Hesperidin, a bioflavonoid with therapeutic benefits, has low water solubility and bioavailability. This limits treatment. This study improved hesperidin solubility and dissolution by making solid dispersions using appropriate carriers. Methodology: Solid dispersions of hesperidin were prepared using two methods: kneading and solvent evaporation. The carriers utilized in the study were polyvinylpyrrolidone K30 (PVP K30) and mannitol. The formulations were evaluated based on various parameters, including yield, solubility, dissolution rate, drug conte

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Senthil Kumar, K. L., P D Gokulan, A. Vasanthan, et al. "Preparation and evaluation of matrix type of transdermal patches containing anti –diabetic drug." Indian Journal of Pharmacy and Pharmacology 9, no. 1 (2022): 33–38. http://dx.doi.org/10.18231/j.ijpp.2022.006.

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The current research aims to formulate and evaluated medicated transdermal patches containing an anti-diabetic drug. A good penetration enhancer would improve drug delivery from various polymer-based transdermal patches. Transdermal patches of the matrix type are made. Using various PVP K30, MC ratios and solvent evaporation techniques. All prepared formulations were tested for weight variation, thickness, drug content, moisture content, moisture uptake, flatness, and in vitro drug release. Bath F3 was optimised formula from all formulation baths shows linear zero order release for 24 hours, w

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Novia, Novia, and Noval Noval. "Pengaruh Kombinasi Polimer Polivinil Pirolidon dan Etil Selulosa terhadap Karakteristik dan Uji Penetrasi Formulasi Transdermal Patch Ekstrak Bawang Dayak (Eleutherine palmifolia (L)." Jurnal Surya Medika 7, no. 1 (2021): 173–84. http://dx.doi.org/10.33084/jsm.v7i1.2653.

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The transdermal patch can deliver the active substance with good bioavailability, then made formulations of such preparations from dayak onion extract, which has a compound content of flavonoids, with a combination of polymer PVP K30 and ethyl cellulose to produce transdermal patches with good physical evaluation and penetration. The research aims to carry out the effect and ideal formulation of transdermal patches of dayak onion extract with a combination of polymers PVP K30 and ethyl cellulose based on physical evaluation and penetration—manufacture of transdermal patches using the solvent e

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16

Rustiani, Erni, Rina Agustina, and Septia Andini. "Formulation and Pharmaceutical Quality Evaluation of Tablets Containing Extract of Cinnamomum burmannii BARK and Colocasia esculenta (L) Schott Leaves." Jurnal Mandala Pharmacon Indonesia 9, no. 1 (2023): 27–34. http://dx.doi.org/10.35311/jmpi.v9i1.292.

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Cinnamon bark (Cinnamomum burmannii) is used traditionally and has an ingredient containing cinnamic acid compounds. Colocasia esculenta (L) Schott leaves contains of flavonoids, alkaloids, tannins, saponins, steroids, and terpenoids. Both of the plants C. esculenta and C. burmannii plants have the potential as anti-diabetics because they can lower blood glucose levels. This study aims to make combination tablets of C. burmannii bark and C. esculenta leaves extract with various concentrations of PVP K30 binder. This research made four formulas with the concentration of PVP K30, namely F1 (2%),

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17

Tandel, D. B., P. A. Shah, K. G. Patel, M. C. Gohel, V. T. Thakkar, and T. R. Gandhi. "IMPROVEMENT OF DISSOLUTION RATE OF FEBUXOSTAT USING HYBRID TECHNIQUE OF SPHERICAL CRYSTALLIZATION AND SOLID DISPERSION." INDIAN DRUGS 52, no. 09 (2015): 32–39. http://dx.doi.org/10.53879/id.52.09.10274.

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The present study was carried out with an aim to improve dissolution rate of febuxostat (FBX, BCSclass II) drug. Spherical agglomerates were prepared by hybrid technique of spherical crystallization and solid dispersion using different ratios of FBX and polymer (PVP K30, HPMC E3LV and chitosan). Drug excipient compatibility study was evaluated by Fourier transform infrared spectroscopy and X-ray diffractometry. Scanning electron microscopy was used for measurement of size of agglomerate. In vitro dissolution study of prepared spherical agglomerates was compared with untreated FBX and marketed

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18

PATEL, MAHENDRA, ARPNA INDURKHYA, and MASHEER AHMED KHAN. "IMPROVEMENT OF DISSOLUTION RATE OF REPAGLINIDE BY UTILIZING SOLID DISPERSION TECHNIQUE." Current Research in Pharmaceutical Sciences 13, no. 1 (2023): 78–82. http://dx.doi.org/10.24092/crps.2023.130107.

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The recent study's objective was to prepare and evaluate the Repaglinide (RG) solid dispersion. RG is poorly water soluble, BCS class II drug. Repaglinide solid dispersion (RG-SD) was prepared by solvent evaporation method using different proportion of PVP K30. The prepared RG-SD was evaluated for solubility studies, drug content, in vitro dissolution, DSC studies and XRD studies. DSC and XRD studies results indicate that RG exists in amorphous form in solid dispersion. The solubility of pure RG was enhanced from 34.41±0.68 to 370.3±1.52 μg/mL in distilled water at 370 C. RG-SD (RG:PVP K30) (1

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Huang, Bin Bin, Dong Xu Liu, De Kun Liu, and Gang Wu. "Application of Solid Dispersion Technique to Improve Solubility and Sustain Release of Emamectin Benzoate." Molecules 24, no. 23 (2019): 4315. http://dx.doi.org/10.3390/molecules24234315.

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The solid dispersion technique, which is widely used in the medical field, was applied to prepare a pesticide dosage form of emamectin benzoate (EM). The preparation, physicochemical characterization, aqueous solubility, release dynamics, photolytic degradation, bioactivity, and sustained-release effects of the prepared EM solid dispersions were studied by a solvent method, using polymer materials as the carriers. Water-soluble polyvinyl pyrrolidone (PVP) K30 and water-insoluble polyacrylic resin (PR)III were used as the carriers. The influence of various parameters, such as different EM:PVP-K

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Chaiya, P., and T. Phaechamud. "Theophylline extended-release monolithic matrix comprising natural rubber latex as binder." IOP Conference Series: Materials Science and Engineering 1234, no. 1 (2022): 012001. http://dx.doi.org/10.1088/1757-899x/1234/1/012001.

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Abstract A major component of polymer in natural rubber latex (NRL) obtained from Hevea brasiliensis consists of poly-cis-1,4-isoprene. Poly-cis-1,4-isoprene exhibited interesting physical properties suitable for possible use as a binder in pharmaceutical solid dosage forms such as monolithic matrix tablet. The aim of this study was to study the feasibility of using NRL as the binder in theophylline anhydrous (THE)-incorporated monolithic matrix tablet in comparison with polyvinyl pyrrolidone K-30 (PVP-30). Physical properties of granules and tablets fabricated with wet granulation and tableti

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Ramadon, Delly, Lissa Florencia Putri Sutrisna, Yahdiana Harahap, et al. "Enhancing Intradermal Delivery of Lidocaine by Dissolving Microneedles: Comparison between Hyaluronic Acid and Poly(Vinyl Pyrrolidone) Backbone Polymers." Pharmaceutics 15, no. 1 (2023): 289. http://dx.doi.org/10.3390/pharmaceutics15010289.

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Lidocaine hydrochloride (LiH), an amide-type local anesthetic agent, is commonly used in dermatological procedures. LiH is categorized as a BCS (biopharmaceutics classification system) class III group, which has high solubility and poor permeability. It should be noted that, in this context, LiH is intended as a local anesthetic, so the level of LiH in systemic circulation should be minimized to avoid toxicity and unwanted side effects such as hypotension and bradycardia. This study aimed to formulate and evaluate LiH-loaded dissolving microneedles (DMNs) with different polymer bases. Moreover

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Suksaeree, Jirapornchai, Patsakorn Siripornpinyo, and Somruethai Chaiprasit. "Formulation, Characterization, and In Vitro Evaluation of Transdermal Patches for Inhibiting Crystallization of Mefenamic Acid." Journal of Drug Delivery 2017 (November 12, 2017): 1–7. http://dx.doi.org/10.1155/2017/7358042.

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The crystallization of mefenamic acid in transdermal patch is a major problem that makes the patch unstable and decreases the drug release. The additive was used to inhibit crystallization of a mefenamic acid. Among the different types of additives, polyvinylpyrrolidone (PVP) K30 and PVP K90 were studied and found to be highly effective in inhibiting the crystallization of the drug. The PVP presented as a solubilizer agent for mefenamic acid in matrix patches at the different ratio between drug : PVP, 1 : 2 and 1 : 2.5 for using PVP K30 and 1 : 1.5 and 1 : 2 for using PVP K90. The characteriza

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Sui, Xiaoyu, Yan Chu, Jie Zhang, et al. "The Effect of PVP Molecular Weight on Dissolution Behavior and Physicochemical Characterization of Glycyrrhetinic Acid Solid Dispersions." Advances in Polymer Technology 2020 (October 30, 2020): 1–13. http://dx.doi.org/10.1155/2020/8859658.

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The effect of polyvinylpyrrolidone (PVP) as glycyrrhetic acid (GA) solid dispersions carrier at different molecular weights on the dissolution behavior and physicochemical properties was investigated. PVP-GA-SDs prepared with all four molecular weight PVPs displayed good enhancement of dissolution rate and equilibrium solubility compared with pure drug and corresponding physical mixtures. The results showed that the enhancement effect of molecular weight on dissolution rate and equilibrium solubility follows PVP K 30 > PVP K 60 > PVP K 17 > PVP K 15 . In addition, the dissolution rate

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Wahyudin Bin Jamaludin, Rifka Azizia, and Aristha Novyra Putri. "FORMULASI DAN EVALUASI MASKER GEL PEEL OFF EKSTRAK ETANOL 70% DAUN SAWO MANILA (MANILKARA ZAPOTA L.)." Jurnal Ilmiah Farmasi Farmasyifa 7, no. 2 (2024): 216–27. http://dx.doi.org/10.29313/jiff.v7i2.3480.

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Ekstrak etanol 70% daun Sawo Manila (Manilkara zapota L.) mengandung senyawa flavanoid, dan fenolik memiliki aktivitas antioksidan sangat kuat dengan IC₅₀ sebesar 8,26 µg/m sehingga berpotensi dikembangkan dalam bentuk sediaan farmasi untuk kulit wajah, salah satunya yaitu masker gel peel off. Tujuan dari penelitian ini adalah untuk menentukan formula yang paling optimal berdasarkan variasi konsentrasi film forming PVA dan gelling agent PVP K30. Penelitian ini dilakukan dengan metode eksperimental dengan variasi PVA 12%, 13%, 14%, dan PVP K30 1%, 5%, 10%. Hasil penelitian organoleptis menunjuk

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Ferdousy, Sonia, BK Sajeeb, Shahida Yeasmin, and ABM Faroque. "Impact Assessment of Different Polymers on Physicochemical Properties of Ibuprofen Loaded Solid Dispersions." Dhaka University Journal of Pharmaceutical Sciences 17, no. 2 (2018): 183–90. http://dx.doi.org/10.3329/dujps.v17i2.39174.

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In the present study, solid dispersions of ibuprofen were prepared to improve aqueous solubility of ibuprofen. A series of formulations were prepared where PEG 6000 with polymers named PVP K30, cross PVP, poloxamer 237, HPMC ASLF, pregelatinized starch, Na-CMC, Eudragit L100, and kollidon IR were used in different ratios. Among 41 formulations, solid dispersions of ibuprofen in PEG 6000 with each of PVP K30, poloxamer 237, and Na-CMC at ratio of 2:9:7 revealed improved solubility of 952.73 ± 1.31, 878.18 ± 0.97, and 1263.64 ± 1.58 μg/ml, respectively. The physicochemical properties of these pr

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Park, Jin Woo, Sa-Won Lee, Jun Hak Lee, et al. "Supersaturated Liquid Formulation of Pazopanib Hydrochloride Loaded with Synergistic Precipitation Inhibitors." Molecules 29, no. 22 (2024): 5267. http://dx.doi.org/10.3390/molecules29225267.

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This study aimed to develop a supersaturated liquid formulation (SSLF) to enhance the solubility and dissolution of pazopanib hydrochloride (PZH). SSLFs were prepared by a simple stirring method in a heated silicon oil bath (70 °C). PZH showed highly pH-dependent solubility (pH 1.2 > water >> pH 4.0 and pH 6.8) at 37 °C. The SSLF containing glycerol and polyvinylpyrrolidone K30 (PVP K30) increased PZH dispersion solubility (273.66 ± 48.91 μg/mL) at pH 6.8 by more than 50-fold compared with that of glycerol alone (<5 μg/mL), and the PZH precipitate particle size was considerably sma

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Gong, Ming, and Chang An Wang. "Preparation and Characterization of Vanadium Pentoxide Hollow Microspheres with Tunable Sizes." Key Engineering Materials 697 (July 2016): 706–9. http://dx.doi.org/10.4028/www.scientific.net/kem.697.706.

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V2O5 hollow microspheres were synthesized by a one-step solvothermal method, with the assistance of PVP as the soft template, ethylene glycol (EG) as the solvent, and vanadium (iii) acetylacetonate (acac) as the metal-ions source. The samples were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), transmission electron microscopy (TEM). The size of V2O5 hollow microspheres, which can be easily tuned by using PVP of different molecular weights, was about 2.5μm, 4.5μm and 6μm when using PVP-K17, PVP-K30 and PVP-K60 as the template, respectively.

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Agung Dewantara Putra, I. Gusti Ngurah, Eka Indra Setyawan, Ni Putu Maya Ninditha, and Made Tresia Pramasta Diva. "Optimization of Non-Effervescet Floating Tablets Ranitidine HCL Formula Using Durian Seed Matrix (Durio Zibethinus Murr) Fully Gelatinized Modified Using Simplex Lattice Design Method." Eduvest - Journal of Universal Studies 3, no. 12 (2023): 2167–83. http://dx.doi.org/10.59188/eduvest.v3i12.964.

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This study investigated the use of fully gelatinated durian seed starch as an excipient in Ranitidine HCl Non-Effervescent Buoyancy Tablets (NEFT). The simplex lattice design method was used to formulate the optimum composition of the formula, including fully gelatinated durian seed starch, PVP K30, and magnesium stearate. Physically modified durian seed starch is expected to increase the release time of active substances in the body. The experiment was conducted for six months by measuring the physical properties of the granule, tablet hardness, solubility, and friability. Results showed that

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Qiao, Fangxia, Yue Zhao, Yaping Mai, et al. "Isoliquiritigenin Nanosuspension Enhances Cytostatic Effects in A549 Lung Cancer Cells." Planta Medica 86, no. 08 (2020): 538–47. http://dx.doi.org/10.1055/a-1134-3378.

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AbstractIsoliquiritigenin, a flavonoid extracted from licorice root, has been shown to be active against most cancer cells; however, its antitumor activity is limited by its poor water solubility. The aim of this study was to develop a stable isoliquiritigenin nanosuspension for enhanced solubility and to evaluate its in vitro cytostatic activity in A549 cells. The nanosuspension of isoliquiritigenin was prepared through wet media milling with HPC SSL (hydroxypropyl cellulose-SSL) and PVP K30 (polyinylpyrrolidone-K30) as stabilizers, and the samples were then characterized according to particl

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Minhas, Muhammad Usman, Kifayat Ullah Khan, Muhammad Sarfraz, et al. "Polyvinylpyrrolidone K-30-Based Crosslinked Fast Swelling Nanogels: An Impeccable Approach for Drug’s Solubility Improvement." BioMed Research International 2022 (August 26, 2022): 1–15. http://dx.doi.org/10.1155/2022/5883239.

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Poor solubility is a global issue of copious pharmaceutical industries as large number of drugs in development stage as well as already marketed products are poorly soluble which results in low dissolution and ultimately dosage increase. Current study is aimed at developing a polyvinylpyrrolidone- (PVP-K30-) based nanogel delivery system for solubility enhancement of poorly soluble drug olanzapine (OLP), as solubilization enhancement is the most noteworthy application of nanosystems. Crosslinking polymerization with subsequent condensation technique was used for the synthesis of nanogels, a hi

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Rahim, Haroon, Abdul Sadiq, Shahzeb Khan, et al. "Isolation and preliminary evaluation of Mulva Neglecta mucilage: a novel tablet binder." Brazilian Journal of Pharmaceutical Sciences 52, no. 1 (2016): 201–10. http://dx.doi.org/10.1590/s1984-82502016000100022.

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ABSTRACT The aim of this study was to evaluate binding potential of Mulva neglecta mucilage (MNM) with subsequent comparison to PVP K30. Eight batches of Diclofenac sodium tablets were prepared by wet granulation technique keeping different concentrations (4, 6, 8 & 10% w/w) of Mulva neglecta mucilage (extracted from leaves of Mulva neglecta) and PVP K30 as standard binder. The granules of formulated batches showed bulk density (g/mL) 0.49 ± 0.00 to 0.57 ± 0.00, tapped density (g/mL) 0.59 ± 0.01 to 0.70 ± 0.01, Carr's index 09.27 ± 0.95 to 19.65 ± 0.59, Hausner's ratio 1.12 ± 0.00 to 1.24

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Sharma, G. S., Vudutha Bhavani, and T. Rama Rao. "Formulation & Evaluation of Sustained Release Diclofenac Sodium Microspheres." International Journal of Health Sciences and Research 14, no. 11 (2024): 181–91. http://dx.doi.org/10.52403/ijhsr.20241120.

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The present work sought to explore the dissolution profile and release kinetics of modified release diclofenac sodium microspheres comprising sodium carboxy methyl cellulose, hydroxy propyl methyl cellulose (HPMC), and polyvinyl pyrrolidine (PVP K30). The impact of these polymers on drug release mechanism was investigated. The Ionic-gelation process was used to create nine formulations with varying quantities of polymers. The FT-IR technique was employed for analysing interactions among polymers and active medicinal molecules. Scanning electron microscopy was utilized to examine the produced m

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Mehta, Hina Deepak, Saravanakumar Kasimedu, Bharath Raj KC, and Vema Kiran4. "Optimizing Orphan Drug Rucaparib Transdermal Patches for Ovarian Cancer: A Design Expert-Based Strategy for Prolonged Drug Release." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 03 (2024): 1441–49. http://dx.doi.org/10.25258/ijddt.14.3.27.

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This study aimed to develop and characterize transdermal patches for rucaparib using a Box-Behnken design (BBD), evaluating drug permeation at 8, 12, and 24 hours, with optimization through Design Expert software. The patches were formulated with HPMC K15, ethyl cellulose, and PVP K30. The physicochemical properties and drug infusion were tested and characterized. The transdermal patches developed in this study were found to be soft and flexible, indicating good handling properties and potential for comfortable application. The patches demonstrated sustained drug release, extending beyond 24 h

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Lusiana, Retno Ariadi, Khabibi Khabibi, Rahmad Nuryanto, and Muhammad Ridho Shofwan Al Aziz. "Development and Characterization of a Chitosan and Polyvinyl Alcohol (CS/PVP)-Based Slow-Release Urea Fertilizer Membrane." Jurnal Kimia Sains dan Aplikasi 27, no. 10 (2024): 470–76. http://dx.doi.org/10.14710/jksa.27.10.470-476.

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A slow-release test of urea fertilizer was conducted using chitosan-urea (CS-U) and chitosan/polyvinyl pyrrolidone K30-urea (CS/PVP-U) membranes. The urea membrane synthesis involved a blending method, with PVP K30 added as a component. The slow-release capabilities of CS-U, CS/PVP1-U, CS/PVP2-U, CS/PVP3-U, and CS/PVP4-U membranes were compared. FTIR results showed an increased intensity of the primary NH double peak at 1587 cm-1 and 1640 cm-1, while the C=O spectrum shifted from 1640 to 1647 cm-1 and the -OH group from 3354 cm-1 to 3362 cm-1, indicating hydrogen bond formation in CS/PVP-U. XR

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Sekti, Beta Herilla, Agung Permata, and Neysa Oktadiva S. P. "FORMULASI DAN UJI STABILITAS FISIK TABLET KEMPA EKSTRAK DAUN PEPAYA ( Carica Papaya. L)." HERBAPHARMA : Journal of Herb Farmacological 4, no. 1 (2022): 53–62. http://dx.doi.org/10.55093/herbapharma.v4i1.289.

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Papaya leaf (Carica Papaya L.) is a plant that contains alkaloids, flavonoids, tripertinoids, saponins and tannins that are useful for treating diabetes. This study aims to obtain compressed tablets of papaya leaf extract and determine the effect of the concentration of PVP K30 as a binder on the physical properties of compressed tablets. The study used an experimental method, with a comparison of formula 1 = 1%, formula 2 = 3% and formula 3 = 5% and tested the physical properties of tablets. The results showed that the tablets met the requirements and only one formula did not meet the tablet

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Kumar, Sanjay, Anirudh Singh Deora, Narahari KV, and Tanveer Shaikh. "Optimizing Transdermal Patch Design: A Quality by Design Approach for Dysmenorrhea Relief." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 03 (2024): 1299–305. http://dx.doi.org/10.25258/ijddt.14.3.07.

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This study explores the potential of transdermal patches as a systemic delivery system for donepezil (DPZ), aiming to circumvent hepatic first-pass metabolism and mitigate oral administration-associated side effects. DPZ, known for its poor solubility and adverse effects, is formulated into transdermal patches using a matrix-type approach with PVP K30 and HPMC K100 polymers alongside dimethyl sulfoxide as a plasticizer. Through solvent casting on a mercury surface, the patches are prepared and assessed for physical properties and drug-excipient interactions using FTIR analysis. The results dem

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Singh, Manju, та Vijay Kumar. "Enhancing Aceclofenac Solubility and Dissolution with PVP K30 and β-Cyclodextrin". International Journal of Advanced Multidisciplinary Research and Studies 4, № 4 (2024): 125–33. http://dx.doi.org/10.62225/2583049x.2024.4.4.3012.

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Aceclofenac (AC) is a potent non-steroidal anti-inflammatory drug (NSAID) known for its anti-inflammatory, analgesic, and antipyretic properties. Its effectiveness is comparable to other NSAIDs, with a similar onset of action. As a Biopharmaceutical Classification System (BCS) Class II compound, the oral bioavailability of AC is limited by its dissolution rate in the gastrointestinal tract. Enhancing the dissolution rate of AC is crucial for improving its bioavailability and therapeutic efficacy. This study aimed to prepare and characterize solid dispersions of AC using a mixed excipient syste

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Santoso, Rahmat, Yanni Dhiani Mardhiani, and Tiwi Febriana Wulandari. "Pemanfaatan Ekstrak Daun Katuk Sauropus Androgynus (L) Merr Dalam Formulasi Sediaan Mikropartikulat Dengan Metode Ekstrusi Sferonisasi." IKRAITH-Teknologi 6, no. 3 (2022): 95–102. http://dx.doi.org/10.37817/ikraith-teknologi.v6i3.2310.

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Pelet merupakan sistem multipartikulat yang memiliki distribusi ukuran partikel 0,5 – 1,5 mm denganmetode ekstrusi sferonisasi. Keunggulan pelet adalah memiliki sifat alir yang baik, dan porositas rendah.Sediaan pelet akan dibuat minuman dengan bahan dasar ekstrak katuk. Katuk (Suaropus androgynus L)umum dikonsumsi masyarakat sebagai sayuran, karena bermanfaat sebagai laktagoga atau pelancar ASI.Pembuatan minuman pelet ekstrak katuk dengan bahan PVP K30, sukralos, dan avicel pH 102. Penelitian inidilakukan untuk membuat minuman pelet dengan memanfaatkan teknologi tepat guna ekstruder, sferonis

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Rodríguez-Espinosa, C., M. C. Martínez-Ohárriz, C. Martín, M. M. Goñi, I. Vélaz, and M. Sánchez. "Dissolution kinetics for coprecipitates of diflunisal with PVP K30." European Journal of Drug Metabolism and Pharmacokinetics 23, no. 2 (1998): 109–12. http://dx.doi.org/10.1007/bf03189324.

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Christopher Vimalson D, Parimalakrishnan S, Jeganathan N S, and Anbazhagan S. "Formulation and evaluation of Olmesartan Medoxomil solid dispersions to enhance its solubility and dissolution characteristics." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 1515–25. http://dx.doi.org/10.26452/ijrps.v11ispl4.4332.

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The objective of the present learns to improve solubility and dissolution of Olmesartan Medoxomil (OM) by improving water solubility by reliable dispersion methods using fusion method (FM) and solvent evaporation (SE) method via hydrophilic polymers PEG 6000 and PVP K30 in different ratios. Preformulation studies of OM: polymers were carried using DSC and FTIR proves that it is stable without any extra peaks, which implies no interaction among the drug and carrier. For OM in FM drug: polymer ratio was maintained in a range 1:1, 1:3, 1:5 and 1:7 w/w ratio of OM to PEG 6000 and coded as SDOM1, S

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Bajracharya, Rajiv, Jae Geun Song, Sang Hoon Lee, Seong Hoon Jeong, and Hyo-Kyung Han. "Enhanced Oral Bioavailability of MT-102, a New Anti-inflammatory Agent, via a Ternary Solid Dispersion Formulation." Pharmaceutics 14, no. 7 (2022): 1510. http://dx.doi.org/10.3390/pharmaceutics14071510.

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This study aimed to develop a solid dispersion (SD) of MT-102, a new anti-inflammatory agent, to improve its oral bioavailability. The ternary SD formulations of MT-102 (a poorly soluble extract of Isatis indigotica and Juglans mandshurica) were prepared using a solvent evaporation method with various drug/excipient ratios. Following that, the effectiveness of various SDs as an oral formulation of MT-102 was investigated using indirubin as a marker component. By forming SDs with hydrophilic polymers, the aqueous solubility of indirubin was significantly increased. SD-F4, containing drug, polox

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Sherikar, Abdulla, Mohd Usman Mohd Siddique, Mahesh More, et al. "Preparation and Evaluation of Silymarin-Loaded Solid Eutectic for Enhanced Anti-Inflammatory, Hepatoprotective Effect: In Vitro–In Vivo Prospect." Oxidative Medicine and Cellular Longevity 2021 (November 10, 2021): 1–13. http://dx.doi.org/10.1155/2021/1818538.

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Solubility of phytochemicals is a major concern for drug delivery, permeability, and their biological response. However, advancements in the novel formulation technologies have been helping to overcome these challenges. The applications of these newer technologies are easy for commercialization and high therapeutic outcomes compared to conventional formulations. Considering these facts, the present study is aimed to prepare a silymarin-loaded eutectic mixture with three different ratios of Polyvinylpyrrolidone K30 (PVP K30) and evaluating their anti-inflammatory, and hepatoprotective effects.

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Adhikari, Vaibhav, Mansi Butola, Vikash Jakhmola, Abhijeet Ojha, and Arvind Negi. "Development and evaluation of an amorphous solid dispersion-based probucol immediate-release tablet." Journal of Applied Pharmaceutical Research 13, no. 2 (2025): 164–71. https://doi.org/10.69857/joapr.v13i2.997.

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Background: In its crystalline form, probucol has an extremely low bioavailability and is a poor water-soluble drug. The main aim of this study was to enhance the solubility and dissolution rate of probucol by using a solvent evaporation method to develop a solid dispersion that contains polyvinyl pyrrolidone K30 (PVP-K30) and polyethylene glycol 6000 (PEG 6000). Methodology: The solvent evaporation method is considered superior to other techniques for preparing solid dispersions due to its ability to achieve uniform drug distribution at the molecular level. This method ensures homogeneity by

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Sudhir, M., M. Manjusha, R. R. Manjula, N. Jyothi, and N. Lakshmi Prasanthi. "PREPARATION AND EVALUATION OF IBUPROFEN LIQUID FILL FORMULATIONS FOR SOFT GELS." INDIAN DRUGS 54, no. 12 (2017): 65–68. http://dx.doi.org/10.53879/id.54.12.10873.

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The present investigation was undertaken with an objective to prepare and evaluate liquid fill formulations of non-steroidal anti-inflammatory drug, ibuprofen (IBU), in order to improve its dissolution properties and thereby its bioavailability. Liquid fill formulations were prepared by employing different co-solvents and surfactants like polyethylene glycol 400 (PEG 400), propylene glycol (PG) and polyvinylpyrrolidone (PVP K-30). The liquid fills were characterized by assay, rheology, clarity, in vitro dissolution studies and FTIR. More than 90% of the drug was released within 5 min from PVP

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Zhou, Shuwen, Qing Wang, Jun Chen, Yue Shen, Li Liu, and Cheng Wang. "Preparation and Optimization of MnO₂ Nanoparticles." Science of Advanced Materials 14, no. 5 (2022): 927–33. http://dx.doi.org/10.1166/sam.2022.4255.

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Manganese dioxide (MnO2) is one of the commonly applied inorganic material which is gaining increasing attentions in recent years. However, preparation and optimization of MnO2 nanoparticles have rarely been studied by previous studies, making the mechanisms responsible for preparation of MnO2 remaining largely unknown. Here in this study, we synthesized MnO2 through reduction of potassium permanganate (KMnO4) using different reductants, including protein, polymers and small molecule organic acids. It was suggested that, stable MnO2 nanoparticles can only be obtained in balanced synthesis/stab

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Rahim, Haroon, Mir Azam Khan, Amin Badshah, Kamran Ahmad Chishti, Salimullah Khan, and Muhammad Junaid. "Evaluation of Prunus domestica gum as a novel tablet binder." Brazilian Journal of Pharmaceutical Sciences 50, no. 1 (2014): 195–202. http://dx.doi.org/10.1590/s1984-82502011000100020.

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To evaluate binding potential of Prunus domestica gum in tablets formulations. Six tablet batches (F-1B to F-6B) were prepared by wet granulation method, containing Avicel pH 101 as diluent, sodium diclofenac as model drug using 10, 15 and 20 mg of Prunus domestica gum as binder and PVP K30 was used as standard binder. Magnesium stearate was used as lubricant. Flow properties of granules like bulk density, tapped density, Carr index, Hausner’s ratio, angle of repose as well as physical parameters of the compressed tablets including hardness, friability, thickness and disintegration time were d

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Mariam Hamid Ali and Kawther Khalid Ahmed. "Solubility and Dissolution Rate Enhancement of Bilastine by Solid Dispersion Technique." Iraqi Journal of Pharmaceutical Sciences 34, no. 1 (2025): 218–29. https://doi.org/10.31351/vol34iss1pp218-229.

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Bilastine (BLS) is non-sedating new-brand H1 antihistamine that has selective peripheral effects, the drug has a problem of an insufficient aqueous solubility and accordingly low dissolution rate, and low bioavailability. Solid dispersion (SD) is one of the most effective techniques for improving the solubility and the dissolution rate of poorly soluble drugs by the dispersion of drug within an inert hydrophilic carrier. The aim of this study is to increase the solubility and dissolution rate of the BLS using SD technique. Twenty-nine BLS SD formulas were prepared using different carrier polym

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Martino, Angelica, Jiyun Jeon, Hyun-Ho Park, Hochun Lee, and Chang-Seop Lee. "Bubble Wrap-like Carbon-Coated Rattle-Type silica@silicon Nanoparticles as Hybrid Anode Materials for Lithium-Ion Batteries via Surface-Protected Etching." Batteries 10, no. 2 (2024): 53. http://dx.doi.org/10.3390/batteries10020053.

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Severe volumetric expansion (~400%) limits practical application of silicon nanoparticles as anode materials for next-generation lithium-ion batteries (LIBs). Here, we describe the fabrication and characterization of a conformal polydopamine carbon shell encapsulating rattle-type silica@silicon nanoparticles (PDA–PEI@PVP–SiO2@Si) with a tunable void structure using a dual template strategy with TEOS and (3-aminopropyl)triethoxysilane (APTES) pretreated with polyvinylpyrrolidone (PVP K30) as SiO2 sacrificial template via a modified Stöber process. Polyethylene imine (PEI) crosslinking facilitat

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Jahangiri, Azin, Mohammad Barzegar-Jalali, Alireza Garjani, et al. "Pharmacological and histological examination of atorvastatin-PVP K30 solid dispersions." Powder Technology 286 (December 2015): 538–45. http://dx.doi.org/10.1016/j.powtec.2015.08.047.

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Martnez, P., M. M. Goñi, R. G. Cantera, C. Martin, C. Dios-Viéitez, and C. Martínez-Ohárriz. "Preparation and dissolution rate of gliquidone-PVP K30 solid dispersions." European Journal of Drug Metabolism and Pharmacokinetics 23, no. 2 (1998): 113–17. http://dx.doi.org/10.1007/bf03189325.

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