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Journal articles on the topic 'PvPI'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Migliore, Rossella, Loredana Ferreri, Danilo Aleo, et al. "p-Sulfonato-Calix[4]arene Micelles Stabilize a Povidone Iodine Solution: Supramolecular Interactions, Iodine Retention, and Bactericidal Activity." Nanomaterials 13, no. 2 (2023): 286. http://dx.doi.org/10.3390/nano13020286.

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Povidone iodine (PVPI) is an antiseptic widely used against a broad spectrum of pathogens. However, undesired side-effects are still associated with PVPI treatment due to the irritant effect of iodine. Reducing the concentration of a PVPI formulation could provide safer and more friendly formulations, for routine use and applications in very delicate organs such as the eye. However, managing the storage of a low-concentration solution of PVPI is challenging due to the high iodine volatility. In this study, we demonstrated that an amphiphilic p-sulfonato-calix[4]arene derivative forming micelle

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2

Grigore, Mihai, Andreea-Maria Grigore, and Adriana-Mihaela Ilieșiu. "Portal Vein Pulsatility: A Valuable Approach for Monitoring Venous Congestion and Prognostic Evaluation in Acute Decompensated Heart Failure." Diagnostics 14, no. 18 (2024): 2029. http://dx.doi.org/10.3390/diagnostics14182029.

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Background: The severity of systemic congestion is associated with increased portal vein flow pulsatility (PVP). Aim: To determine the usefulness of PVP as a marker of decongestion and prognosis in acute decompensated heart failure (ADHF) patients. Methods: 105 patients, 60% of whom were men, were hospitalized with ADHF, and their PVP index (PVPI) was calculated (maximum velocity–minimum velocity/maximum velocity) × 100 on admission and before discharge, along with their EVEREST score, inferior vena cava diameter (IVC), NT-proBNP, serum sodium, and glomerular filtration rate. A PVPI ≥ 50% was

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Peng, Kang-Wei, Ming-Ling Chang, Rong-Nan Chien, et al. "Pulmonary Vascular Permeability and Extravascular Lung Water Index in Patients with Liver Cirrhosis and Septic Shock." Journal of Clinical Medicine 13, no. 13 (2024): 3796. http://dx.doi.org/10.3390/jcm13133796.

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Backgrounds and Aims: Patients with cirrhosis are susceptible to sepsis and septic shock. Cirrhotic patients also have increased capillary permeability and are prone to developing volume overload. Patients with septic shock may have an enhanced pulmonary vascular permeability index (PVPI) and extravascular lung water index (EVLWI), both of which are associated with an unfavorable prognosis. It is plausible that pre-existing hyperpermeability may deteriorate when cirrhotic patients develop septic shock. However, it remains unknown whether PVPI and EVLWI can predict the prognosis of cirrhotic pa

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4

Mehak, Chandhok*1 Sarita Gautam2. "Evaluating The Functioning and Significance of The Pharmacovigilance Programme of India." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 2967–75. https://doi.org/10.5281/zenodo.15105150.

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Pharmacovigilance (PV) is very important in safety surveillance of drugs and Adverse Drug Reaction (ADRs) with greater public health benefits. According to WHO, pharmacovigilance is a branch of pharmacoepidemiology concerned with the epidemiology of adverse effects or other drug related problems. The current demand for improved health and extended access to needed medical care and the steadily rising global consumption of drugs demonstrate the need for durable PV systems. In 2010, Pharmacovigilance Programme of India, PvPI was started under the Ministry of Health & Family Welfare, initiall

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Dr V KALAISELVAN, Dr NISHITH KESERWANI, Dr RISHI KUMAR, Dr RAJEEV SINGH RAGHUVANSHI, and Dr KRISHNAMURTHY B. "Birth Defects with the Use of Valproate: An Impact on the Prescribing Pattern amongst the Health Care Professionals in India." Indian Journal Of Clinical Practice 35, no. 1 (2024): 20–27. http://dx.doi.org/10.59793/ijcp.v35i1.1030.

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Objective: The present study was carried out to evaluate the impact of Pharmacovigilance Programme of India (PvPI) initiative to reduce the use of sodium valproate/valproic acid (SV/VA) in the women of childbearing age group. Methods: In our questionnaire-based study, 251 health care professionals (HCPs) participated from 41 medical colleges across India, which are also working as Adverse drug reaction Monitoring Centres (AMCs) under PvPI. Results: The data collected at the National Coordination Centre (NCC) shows the significant decrease in the use of SV/VA in the women of childbearing age gr

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Tabane, Tumelo H., and Bareki S. Batlokwa. "A comparative evaluation of two approaches for loading a therapeutic agent into custom fabricated electrospun nanofiber based innovative wound bandages." Journal of Drug Delivery and Therapeutics 13, no. 11 (2023): 73–80. http://dx.doi.org/10.22270/jddt.v13i11.6254.

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In this work, we evaluated two different approaches; the pvpi_blended and the pvpi_soaked approaches, of loading a model therapeutic agent, povidone-iodine (pvpi), into innovatively fabricated, electrospun poly-Ɛ-caprolactone (PCL) nanofiber based wound bandages. The two loading approaches were compared based on the critical parameters that an excellent wound dressing material must possess; loading capacity, therapeutic agent releasing behavior and wettability. From the results, the pvpi_blended approach PCL nanofiber mats with their higher calculated pvpi loading capacities of 97.0% outperfor

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Westphal, Fernando Luiz, Luiz Carlos de Lima, Ricardo Alexandre Guimarães, Risonilce Fernandes Silva de Souza, Saulo Brasil do Couto, and Sílvia Rocha Nakajima. "Avaliação das alterações pleuropulmonares após a injeção de óleo de resina de copaíba, extrato aquoso de crajiru e polivinilpirrolidona iodado (PVPI) na pleura e parênquima pulmonar de ratos." Revista do Colégio Brasileiro de Cirurgiões 34, no. 3 (2007): 170–76. http://dx.doi.org/10.1590/s0100-69912007000300007.

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OBJETIVO: Avaliar as alterações anatomopatológicas e histopatológicas da pleura e do parênquima pulmonar após a injeção de óleo de copaíba, extrato aquoso de crajiru e polivinilpirrolidona iodado (PVPI) no espaço pleural de ratos. MÉTODO: Foram utilizados 128 Rattus norvegicus var. Wistar, machos, com peso médio 198,9g (± 24,9g), randomizados em quatro grupos: copaíba, PVPI, crajiru e simulação. As substâncias foram injetadas no espaço pleural direito dos animais, os quais foram mortos em 24 h, 48 h, 72 h e 504 h, para análise macro e microscópica da pleura visceral e pulmão direito. RESULTADO

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Sarwar, Dr Sheeraz, Dr Tania Nazir, Dr Safeena Sarwar, Dr Vishal R Tandon, and Dr Sapna Gupta. "Completeness and Quality of ADR reports published in Leading Biomedical Journals." Journal of Medical and Dental Science Research 11, no. 8 (2024): 37–44. http://dx.doi.org/10.35629/076x-11083744.

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To study the completeness of ADR reports published in leading Indian biomedical, pharmacological or medical journals.The quality and completeness of published ADR reports in leading Bio Medical Journals can prove very vital in the effective implementation of drug safety programmes in the form of PvPI in the country. It will further, go long ways to assure the quality assurance of PvPI not only at National Coordination Centre but also at the respective AMC level.

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Lusiana, Retno Ariadi, Khabibi Khabibi, Rahmad Nuryanto, and Muhammad Ridho Shofwan Al Aziz. "Development and Characterization of a Chitosan and Polyvinyl Alcohol (CS/PVP)-Based Slow-Release Urea Fertilizer Membrane." Jurnal Kimia Sains dan Aplikasi 27, no. 10 (2024): 470–76. http://dx.doi.org/10.14710/jksa.27.10.470-476.

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A slow-release test of urea fertilizer was conducted using chitosan-urea (CS-U) and chitosan/polyvinyl pyrrolidone K30-urea (CS/PVP-U) membranes. The urea membrane synthesis involved a blending method, with PVP K30 added as a component. The slow-release capabilities of CS-U, CS/PVP1-U, CS/PVP2-U, CS/PVP3-U, and CS/PVP4-U membranes were compared. FTIR results showed an increased intensity of the primary NH double peak at 1587 cm-1 and 1640 cm-1, while the C=O spectrum shifted from 1640 to 1647 cm-1 and the -OH group from 3354 cm-1 to 3362 cm-1, indicating hydrogen bond formation in CS/PVP-U. XR

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Araujo, Ivana Duval de, Giovanni Cezar Xavier Grossi, Simone Odília Fernandes Diniz, Tarcizo Afonso Nunes, Eduardo Ângelo Braga, and Valbert Nascimento Cardoso. "Effects of the povidone-iodine (PVPI) in treatment of bacterial peritonitis induced in rats." Acta Cirurgica Brasileira 25, no. 4 (2010): 322–27. http://dx.doi.org/10.1590/s0102-86502010000400004.

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PURPOSE: To evaluate the effectiveness of the use of the povidone-iodine (PVI) added to the liquid of wash of the peritoneal cavity in the reduction of bacterial absorption and in the remainder non-phagocyted bacteria in the circulating blood of rat. METHODS: Thirty four Wistar females rats were used, distributed in the following groups: A (n=10), non-treated; B (n=9), wash of the peritoneal cavity with solution of PVI to 1% in saline solution; C (n=15), wash of the cavity with saline solution. After anesthesia, it was made intraperitoneal infusion of solution of Escherichia coli labeled with

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Raghute, Latesh B., Sujata Dudhgaonkar, Kavita M. Jaiswal, Akhilesh Singh Parihar, Swapna M. Bhalerao, and Sagrika R. Jumle. "Angioedema caused by over the counter use of dicyclomine hydrochloride and paracetamol fixed dose combination in a child: a case report." International Journal of Basic & Clinical Pharmacology 7, no. 8 (2018): 1659. http://dx.doi.org/10.18203/2319-2003.ijbcp20183040.

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Authors describe a case of angioedema in a male child due to over-the-counter (OTC) use of fixed dose combination (FDC) of Tab. dicyclomine hydrochloride (20mg) and paracetamol (500mg) for abdominal pain. Use of OTC drugs in children without a doctor’s suggestion can lead to unnecessary medication use and is not free of risks. Here, there is a probable causal relationship between the suspected drug and angioedema according to WHO-UMC criteria for Causality Assessment. This case was also reported to the Pharmacovigilance Programme of India (PvPI) through PvPI ADR android application.

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Lusiana, Retno Ariadi, Riska Nurfida Annisa, Vinsencius Guntur Pandu Marcellino, Didik Setiyo Widodo, and Hasan Muhtar. "Fabrication and Characterization of Chitosan-Polyvinyl Pyrolidone K-30 for Creatinine Transport Membranes." Jurnal Kimia Sains dan Aplikasi 26, no. 10 (2023): 381–90. http://dx.doi.org/10.14710/jksa.26.10.381-390.

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The investigation of membrane-based hemodialysis is an interesting study due to its efficacy in eliminating metabolic waste compounds, such as creatinine, from the body. However, not all membrane types exhibit optimal transport capabilities, necessitating modifications. In this study, we conducted modifications on chitosan (CS) membranes by incorporating polyvinyl pyrrolidone K-30 (PVP K-30) and assessing their physicochemical characteristics. The modified membrane underwent characterization and subsequent evaluation of its transport capabilities. The primary objective of this research is to d

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Kumar, Rishi, Jai Prakash, Shashi Bhushan, Akash Deep Rawat, R. S. Ray, and Rajeev Singh Raghuvanshi. "Training and education in pharmacovigilance: The experience from the Pharmacovigilance Programme of India." Indian Journal of Pharmacology 56, no. 5 (2024): 348–57. https://doi.org/10.4103/ijp.ijp_638_22.

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Abstract For a robust Pharmacovigilance system in a country, training of healthcare professionals is of utmost importance. The training is the integral part of continual improvement in any quality management system. The present article describes the different training modules and experience from the Pharmacovigilance Programme of India (PvPI) and emphasizes that if training and education elements with special reference to pharmacovigilance are implemented for all concerned stakeholders in a healthcare system, the efficiency of deliverables will be improved and objectives of the organization ca

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Tabane, Tumelo H., and Bareki S. Batlokwa. "Fabrication of innovative wound exudates dissolvable electrospun povidone-iodine loaded poly (Ɛ-caprolactone)-poly (ethylene oxide) composite nanofiber mat based wound bandages." Journal of Drug Delivery and Therapeutics 13, no. 11 (2023): 91–101. http://dx.doi.org/10.22270/jddt.v13i11.6300.

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Changing of bandage when nursing chronic wounds is a necessary exercise that encourages effective wound healing but often the bandage gets stuck to the wound, making changing it painful and uncomfortable. Furthermore, most of the wound medicine that is usually smeared on the bandage gets thrown away with the removed bandage unused. To deal with these challenges, we fabricated an innovative, dissolvable, drug releasing bandage based on electrospun povidone iodine (pvpi) blended poly (Ɛ-caprolactone), PCL-poly (ethylene oxide), PEO, composite nanofiber mats. From the experiments, smooth, yellow

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15

Gadhade, Jyoti B., Rajesh S. Hiray, Rekha Y. Aherkar, and Kalpana U. Shah. "Pharmacovigilance programme of India: revival of the renaissance." International Journal of Basic & Clinical Pharmacology 7, no. 11 (2018): 2281. http://dx.doi.org/10.18203/2319-2003.ijbcp20184338.

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Adverse drug reactions (ADRs) are the fourth leading cause of morbidity in the world. In order to safeguard the health of the community, Pharmacovigilance Programme of India (PvPI) is implemented as the monitoring body by Indian Pharmacopoeia Commission (IPC). It is leading national authority. National Coordinating Centre (NCC) PvPI works as the World Health Organization (WHO) collaborating centre for pharmacovigilance. Adverse drug reactions are reported to NCC PvPI which are then directed towards WHO Uppsala Monitoring Centre (UMC) Sweden which is the global monitoring centre for worldwide d

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16

Wu, Shang-Heng, Jen-Fu Lin, and Rong-San Jiang. "Antibacterial Effect of Hypochlorous Acid Solution on Nasal Discharge from Patients with Chronic Rhinosinusitis." International Journal of Otolaryngology 2018 (2018): 1–5. http://dx.doi.org/10.1155/2018/8568694.

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Purpose. The antibacterial effect of hypochlorous acid (HOCl) solution on nasal secretion of patients with chronic rhinosinusitis (CRS) was investigated. Materials and Methods. Five swab specimens were collected from the middle meatus of CRS patients. The first one was placed directly in a Thanswab tube while all of the others were placed randomly into 4 glass tubes containing either HOCl solution, normal saline (NS), 75% alcohol, or povidone-iodine (PVPI) solution for one minute in the first part and for 5 minutes in the second part of the study before transfer to a Thanswab tube. Results. Ba

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Horie, Nobutaka, Mitsutoshi Iwaasa, Eiji Isotani, Shunsuke Ishizaka, Tooru Inoue, and Izumi Nagata. "Impact of Clipping versus Coiling on Postoperative Hemodynamics and Pulmonary Edema after Subarachnoid Hemorrhage." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/807064.

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Volume management is critical for assessment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH). This multicenter prospective cohort study compared the impact of surgical clipping versus endovascular coiling on postoperative hemodynamics and pulmonary edema in patients with SAH. Hemodynamic parameters were measured for 14 days using a transpulmonary thermodilution system. The study included 202 patients, including 160 who underwent clipping and 42 who underwent coiling. There were no differences in global ejection fraction (GEF), cardiac index, systemic vascular resistance in

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Shiv, Shankar, Ranjan Vivek, Singh Akriti, and Kumar Nitin. "A Prospective Study to Assess the Correlation between EVLWI and PVPI with the Severity of Lung Injury in Patients Admitted with Septic Shock in Intensive Care Unit." International Journal of Pharmaceutical and Clinical Research 14, no. 8 (2022): 912–19. https://doi.org/10.5281/zenodo.13362789.

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<strong>Aim: </strong>The aim of the present study was conducted in the Intensive Care Unit (ICU) of our institute, with an aim to assess the correlation between EVLWI and PVPI with the severity of lung injury in patients with septic shock. <strong>Methods: </strong>The present study was conducted in the Department of  Critical Care medicine (Anesthesiology), IGIMS, Patna, Bihar, India for 1 year. <strong>Results: </strong>The chest radiograph scores from both radiologists strongly correlated with EVLWI (r = 0.75 and 0.70 for observers 1 and 2, respectively, P &lt

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Lardet, Florian, Xavier Monnet, Jean-Louis Teboul, et al. "Relationship of Extravascular Lung Water and Pulmonary Vascular Permeability to Respiratory Mechanics in Patients with COVID-19-Induced ARDS." Journal of Clinical Medicine 12, no. 5 (2023): 2028. http://dx.doi.org/10.3390/jcm12052028.

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During acute respiratory distress syndrome (ARDS), the increase in pulmonary vascular permeability and lung water induced by pulmonary inflammation may be related to altered lung compliance. A better understanding of the interactions between respiratory mechanics variables and lung water or capillary permeability would allow a more personalized monitoring and adaptation of therapies for patients with ARDS. Therefore, our main objective was to investigate the relationship between extravascular lung water (EVLW) and/or pulmonary vascular permeability index (PVPI) and respiratory mechanic variabl

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Masa, Roland, István Pelsőczi-Kovács, Zoltán Aigner, Albert Oszkó, Kinga Turzó, and Krisztina Ungvári. "Surface Free Energy and Composition Changes and Ob Cellular Response to CHX-, PVPI-, and ClO2-Treated Titanium Implant Materials." Journal of Functional Biomaterials 13, no. 4 (2022): 202. http://dx.doi.org/10.3390/jfb13040202.

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The study evaluated the interaction of a titanium dental implant surface with three different antibacterial solutions: chlorhexidine, povidone-iodine, and chlorine dioxide. Implant surface decontamination is greatly challenging modern implant dentistry. Alongside mechanical cleaning, different antibacterial agents are widely used, though these could alter implant surface properties. Commercially pure (CP) grade 4 titanium (Ti) discs were treated with three different chemical agents (chlorhexidine 0.2% (CHX), povidone-iodine 10% (PVPI), chlorine dioxide 0.12% (ClO2)) for 5 min. Contact angle me

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O.M., Vergun, Rakhmetov D.B., Rakhmetova S.O., and Fishchenko V.V. "The content of nutrients and energetic value of the plant raw material of switchgrass (Panicum virgatum L.) genotypes." Plant Introduction 80 (December 1, 2018): 82–88. https://doi.org/10.5281/zenodo.2576109.

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<strong>Objective </strong>– to investigate biochemical properties of plant raw material of 1 cultivar and 14 varieties of <em>Panicum virgatum</em> L. in conditions of M.M. Gryshko National Botanical Garden of the NAS of Ukraine. <strong>Material and methods.</strong> Investigated plants were 1 cultivar and 14 varieties of <em>Panicum virgatum</em> collected in an experimental collection of Cultural Flora Department of National Botanical Garden of the NAS of Ukraine: <em>Panicum virgatum</em> f. <em>DB </em>(PVDB), <em>P. virgatum</em> f. <em>DN </em>(PVDN), <em>P. virgatum</em> f. <em>

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Ranjeet, Kumar, and kant Shashi. "A Study to Assess how Effective Extravascular Lung Water Measurement is in Controlling Lung Damage in Critical Care Units." International Journal of Pharmaceutical and Clinical Research 13, no. 3 (2021): 45–52. https://doi.org/10.5281/zenodo.14199156.

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<strong>Aim: </strong>To evaluate the use of extravascular lung water measurement in managing lung injury in intensive care unit. <strong>Methods: </strong>This was a prospective observational study conducted in the Department of Anaesthesia, Netaji Subhas Medical College and Hospital, Bihta, Patna, India for 12 months. 50 critically ill patients between 18 and 65 years of age with an admission diagnosis of septic shock with or without ARDS with Acute Physiology and Chronic Health Evaluation II ≥20 requiring mechanical ventilation were included in this study. EVLW indexed to

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Obata, Yoshiki, Junichi Takeda, Yohei Sato, Hiroyasu Ishikura, Toru Matsui, and Eiji Isotani. "A multicenter prospective cohort study of volume management after subarachnoid hemorrhage: circulatory characteristics of pulmonary edema after subarachnoid hemorrhage." Journal of Neurosurgery 125, no. 2 (2016): 254–63. http://dx.doi.org/10.3171/2015.6.jns1519.

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OBJECT Subarachnoid hemorrhage (SAH) is often accompanied by pulmonary complications, which may lead to poor outcomes and death. This study investigated the incidence and cause of pulmonary edema in patients with SAH by using hemodynamic monitoring with PiCCO-plus pulse contour analysis. METHODS A total of 204 patients with SAH were included in a multicenter prospective cohort study to investigate hemodynamic changes after surgical clipping or coil embolization of ruptured cerebral aneurysms by using a PiCCO-plus device. Changes in various hemodynamic parameters after SAH were analyzed statist

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Jain, Atul, Arpita Singh, Ajay Kumar Verma, and Manish Soni. "Assessment of awareness towards pharmacovigilance programme of india and reporting of adverse drug reactions among nurses in a tertiary care hospital." International Journal of Basic & Clinical Pharmacology 7, no. 7 (2018): 1357. http://dx.doi.org/10.18203/2319-2003.ijbcp20182682.

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Background: The success of PvPI depends upon spontaneous reporting of ADRs by health care professionals especially nurses as they are usually first contact persons for patients in case of ADRs after use of medicines. Underreporting of ADRs due to inadequate reporting culture among health care professionals is the main hindrance in the path of this programme. So, to assess the awareness, attitude and practices of nurses regarding PvPI and ADR reporting this study was undertaken.Methods: It was a cross-sectional, questionnaire-based study in which 130 nurses responded. The 12-items questionnaire

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Vedant Sheth, Dhaval Chauhan, Ganesh Sharma, and S P Srinivas Nayak. "A Study on Pharmacovigilance in the Hospitalized Pediatric Patients at Tertiary Care Hospital." Parul University Journal of Health Sciences and Research 3, no. 1 (2024): 52–64. https://doi.org/10.62373/pujhsr.2024.113.

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Pharmacovigilance is a critical aspect of public health, aiming to detect, assess, understand, and prevent adverse effects and other drug-related issues. It plays a pivotal role not only in the development phase of medications but also in post-marketing surveillance, ensuring ongoing safety and efficacy. In India, the Pharmacovigilance Programme (PvPI) spearheaded by the All India Institute of Medical Sciences (AIIMS) aims to safeguard public health by collating and analyzing data to inform regulatory interventions and communicate risks to healthcare professionals and the public. The classific

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CUI, Juan, Chun-sheng LI, Xin-hua HE, and Yu-guo SONG. "Protective effects of penehyclidine hydrochloride on acute lung injury caused by severe dichlorvos poisoning in swine." Chinese Medical Journal 126, no. 24 (2013): 4764–70. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20130230.

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Background Organophosphate poisoning is an important health problem in developing countries which causes death mainly by inducing acute lung injury. In this study, we examined the effects of penehyclidine hydrochloride (PHC), a selective M-receptor inhibitor, on dichlorvos-induced acute lung injury in swine. Methods Twenty-two female swines were randomly divided into control (n=5), dichlorvos (n=6), atropine (n=6), and PHC (n=5) groups. Hemodynamic data, extravascular lung water index (EVLWI), and pulmonary vascular permeability index (PVPI) were monitored; blood gas analysis and acetylcholine

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Paiva, Maria de Lourdes, Walquiria Gleice Nogueira da Silva, and Ingrid Felix Teixeira. "Avanços no tratamento da oftalmia neonatal / método Credé: Uma revisão integrativa." Revista Eletrônica Acervo Saúde, no. 17 (November 20, 2018): e54. http://dx.doi.org/10.25248/reas.e54.2019.

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Objetivo: O presente trabalho objetivou abordar os avanços no tratamento da Oftalmia Neonatal (ON). Método: Trata-se de uma Revisão Integrativa da literatura. Foram pesquisadas as bases de dados Biblioteca Virtual em Saúde (BVS): Scientific Electronic Library Online (SciELO), Medical Literature Analysis and Retrieval System Online (MEDLINE) e Literatura Latino Americana e do Caribe em Ciências da Saúde (LILACS) levando–se em consideração a produção científica no período de 2001 a 2018, nos idiomas português, inglês e francês. Utilizaram-se os Descritores em Ciências da Saúde (DeCS): Oftalmia N

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Patel, Nirav N., Devanshu J. Patel, and Haresh A. Desai. "Knowledge, attitude and practice of adverse drug reaction reporting among healthcare professionals of a tertiary care hospital in Gujarat." International Journal of Basic & Clinical Pharmacology 8, no. 10 (2019): 2207. http://dx.doi.org/10.18203/2319-2003.ijbcp20194256.

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Background: The objective of the present study was to assess knowledge, attitude and practice of adverse drug reaction reporting among healthcare professionals of Parul Sevashram Hospital, Parul University, Vadodara.Methods: The study was prospective, observational and questionnaire-based involving medical doctors, nurses and pharmacists of Parul Sevashram Hospital. A total number of 210 structured questionnaires were distributed among health care professionals (100 clinicians from various specialities, 100 nurses and 10 pharmacists). Written informed consent forms were obtained from participa

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S*, Singh. "Overview on Pharmacovigilance: Ensuring Medication Safety." Advances in Pharmacology and Clinical Trials 9, no. 2 (2024): 1–10. http://dx.doi.org/10.23880/apct-16000235.

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Pharmacovigilance plays a pivotal role in ensuring drug safety by monitoring and evaluating the effects of medications before and after their market launch. In India, a rapidly expanding pharmaceutical industry coupled with a diverse patient population and growing drug consumption necessitates robust pharmacovigilance measures. This abstract highlights the need for pharmacovigilance in India, emphasizing factors such as the expansion of the pharmaceutical sector, diverse patient demographics, increased drug consumption, limited awareness and reporting, regulatory compliance, globalization of c

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Sharma, Taruna, D. C. Dhasmana, Rajendra Sharma, Suman Bala, Upasana Sharma, and Upma George. "Knowledge attitude and practice of pharmacovigilance among nursing professionals in a tertiary care teaching hospital in Dehradun, Uttarakhand." International Journal of Basic & Clinical Pharmacology 6, no. 2 (2017): 414. http://dx.doi.org/10.18203/2319-2003.ijbcp20170340.

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Background: Pharmacovigilance deals with identification, assessment and prevention and reporting of adverse drug reaction (ADR), play a pivotal role in ensuring safe use of drugs. However, in spite of having well established ADR reporting system in India and worldwide, the ADR underreporting is a big challenge till date. It is therefore very important to assess the level of awareness of Pharmacovigilance among healthcare professionals to identify the factors affecting ADRs reporting. The objective of the study was to evaluate knowledge, attitude and practice of pharmacovigilance among nursing

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Aditi Chauhan, Adarsh Keshari, Saaransh Handa, and Rhea Aggarwal. "Signal to Safety: Unpacking the Pharmacovigilance Program of India (PVPI)." World Journal of Biology Pharmacy and Health Sciences 22, no. 3 (2025): 615–28. https://doi.org/10.30574/wjbphs.2025.22.3.0623.

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The Pharmacovigilance Programme of India (PVPI), established in 2010, has become a cornerstone of India’s public health strategy for drug safety. This review critically examines PVPI’s evolution, organizational structure, reporting mechanisms, and signal detection processes. Key achievements include a dramatic increase in Individual Case Safety Reports (ICSRs), the expansion of the AMC network, digital innovations such as the ADR PVPI app, and recognition as a WHO Collaborating Centre. PVPI’s regulatory interventions, such as label changes for carbamazepine-induced Stevens–Johnson Syndrome, de

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Mukhyaprana, Sudha K., Siddiraju Devipriya, and Meenakshi Thirumalaiappan. "Study of adverse drug reactions associated with antiepileptic drugs: a pharmacovigilance study using spontaneous reporting system." International Journal of Basic & Clinical Pharmacology 10, no. 9 (2021): 1125. http://dx.doi.org/10.18203/2319-2003.ijbcp20213368.

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Background: More than 25 antiepileptic drugs (AEDs) are available in the Indian market to treat epilepsy of which many have similar efficacy but differ in their tolerability and are associated with many adverse drug reactions (ADRs). ADRs are one of the most common causes of death and clinical trials are not sufficient to uncover all the ADRs, hence post-marketing surveillance or pharmacovigilance is necessary. The aim of the study was to analyze the ADRs of AEDs by spontaneous reporting system under Pharmacovigilance Program of India (PvPI).Methods: Suspected ADR reporting forms provided by P

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Mishra, Pooja Solanki, and Gopal Gudsurkar. "Cross sectional study to assess the awareness of pharmacovigilance among post graduate residents of tertiary care medical college hospital of central India." International Journal of Basic & Clinical Pharmacology 7, no. 3 (2018): 386. http://dx.doi.org/10.18203/2319-2003.ijbcp20180501.

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Background: Pharmacovigilance knowledge and awareness in post graduate student doctors is key factor for proper implementation of PvPI. This study was planned to evaluate the knowledge &awareness of pharmacovigilance in post graduate students in tertiary care centre in Indore.Methods: It was a single point cross sectional questionnaire-based study conducted in a tertiary care Institute MGM Medical College & M.Y. Hospital in the state of Madhya Pradesh at Indore. It was conducted among post graduate student doctors from various clinical departments. Total of 150 questionnaires were dist

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Muthukumar, Vithusan, Lei Shi, Ning Chai, et al. "Efficacy of Off-Label Anti-Amoebic Agents to Suppress Trophozoite Formation of Acanthamoeba spp. on Non-Nutrient Agar Escherichia Coli Plates." Microorganisms 10, no. 8 (2022): 1642. http://dx.doi.org/10.3390/microorganisms10081642.

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Acanthamoeba keratitis (AK) is a dangerous infectious disease, which is associated with a high risk of blindness for the infected patient, and for which no standard therapy exists thus far. Patients suffering from AK are thus treated, out of necessity, with an off-label therapy, using drugs designed and indicated for other diseases/purposes. Here, we tested the capability of the off-label anti-amoebic drugs chlorhexidine (CH; 0.1%), dibromopropamidine diisethionate (DD; 0.1%), hexamidine diisethionate (HD; 0.1%), miltefosine (MF; 0.0065%), natamycin (NM; 5%), polyhexamethylene biguanide (PHMB;

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Gudsurkar, Gopal, Vikalp Tiwari, and Pooja Solanki Mishra. "Assessment of knowledge, attitudes and practice among the post graduate students of dentistry and physiotherapy towards adverse drug reactions reporting and pharmacovigilance at a tertiary care centre at Indore, India." International Journal of Basic & Clinical Pharmacology 7, no. 4 (2018): 626. http://dx.doi.org/10.18203/2319-2003.ijbcp20181159.

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Background: Pharmacovigilance knowledge and training in post graduate student doctors is key factor for proper implementation of PvPI. Often the dentists and physiotherapists who are also one of the main stakeholders for ADR reporting are neglected for training and knowledge regarding pharmacovigilance. This study was planned to evaluate the knowledge and awareness of pharmacovigilance in post graduate students in tertiary care centre in Indore.Methods: It was a single point cross sectional questionnaire-based study conducted in a tertiary care Institute MGM Medical College and M.Y. Hospital i

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Vinutha, Sondi, Kuna Kamala, and Nethala Suresh. "A study of patterns of adverse drug reactions in a tertiary care hospital of Andhra Pradesh, India." International Journal of Basic & Clinical Pharmacology 8, no. 5 (2019): 860. http://dx.doi.org/10.18203/2319-2003.ijbcp20191542.

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Background: Pharmacovigilance Programme of India (PVPI) is a step towards participation in WHO programme for International Drug Safety Monitoring. Pharmacovigilance (PV) system is an integral part of drug therapy, which helps in detection, monitoring and designing strategies to minimize the occurrence of Adverse Drug Reaction (ADRs). The present study is done to study the patterns of ADRs in a tertiary care government hospital.Methods: A total of 327 suspected ADR reports submitted to the pharmacovigilance unit at department of pharmacology under PVPI were evaluated for a period of two years w

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Nanjundappa, Shiva Murthy, and Chinmaya Mahapatra. "Impact of National pharmacovigilance week: A masterstroke by IPC-PvPI." Journal of Pharmacovigilance and Drug Research 2, no. 4 (2021): 3–5. http://dx.doi.org/10.53411/jpadr.2021.2.4.2.

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Yamuna Devi M. S., Saratha Muthukumar, and Kaavya S. "Awareness among consumers on adverse drug reaction reporting system in India - A cross-sectional questionnaire-based study." International Journal of Research in Pharmaceutical Sciences 12, no. 2 (2021): 1276–82. http://dx.doi.org/10.26452/ijrps.v12i2.4677.

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The adverse drug reaction (ADR) reporting system in India came into existence in 2010 through an initiative by the Government, the Pharmacovigilance Programme of India (PvPI), considering the social and economic consequences of drug effects. Though the system is functioning effectively for almost a decade, there has been a lacuna in reporting due to the lack of awareness among the patients who are the direct consumers. Medicine side-effects reporting is the newest initiative started in 2014 by PvPI, and the forms for consumer reporting is made available in over 10 different Indian languages li

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Cardoso, Matheus Völz. "Uso de agentes antimicrobianos como solução refrigerante no ultrassom para tratamento das doenças periodontais: uma revisão de literatura." Revista da Faculdade de Odontologia - UPF 25, no. 2 (2021): 291–302. http://dx.doi.org/10.5335/rfo.v25i2.10556.

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Objetivo: revisar a literatura quanto ao uso de soluções no reservatório líquido do ultrassom (US) para o tratamento das doenças periodontais, avaliando as contribuições dessa associação e as soluções mais eficazes para essa terapêutica. Métodos: foi realizada pesquisa bibliográfica nas bases de dados Public Medline (PubMed), Lilacs, Science Direct e ISI web of knowledge. As palavras-chave utilizadas foram: “periodontal disease”, “ultrasonic”, “cooling solution”, “antimicrobial” e “irrigation”. Como critérios de inclusão, foram selecionados estudos prospectivos, retrospectivos, caso controle,

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Tan, Ruimin, Yating Yan, Huihui Yang, et al. "Clinical efficacy of ulinastatin in patients with pulmonary edema: A systematic review and meta-analysis of randomized controlled trials." Medicine 104, no. 1 (2025): e41145. https://doi.org/10.1097/md.0000000000041145.

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Objective: To methodically assess the clinical impact of ulinastatin on patients suffering from pulmonary edema. Methods: PubMed, Web of Science, Cochrane Library, Embase, Chinese National Knowledge Infrastructure (CNKI), Wanfang data, Chinese Scientific Journal Database (VIP), and Chinese Biomedical Literature Database (CBM) databases were searched using such keywords as ulinastatin, pulmonary edema, and randomized controlled trial (RCT). The search time was from the establishment of the database to August 2023. Two researchers were responsible for literature screening and data collection res

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Aishwarya, Rathod Kavita M. Jaiswal Sujata Dudhgaonkar Latesh B. Raghute Nandkishore Jaiswal. "Evaluation Of Knowledge, Attitude And Practices Of Pharmacovigilance In Health Care Professionals Of Tertiary Care Teaching Institute In Tribal Region Of Central India." British Journal of BioMedical Research 03, no. 03 (2019): 873–81. https://doi.org/10.24942/bjbmr.2019.488.

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B<strong>ackground:</strong> Adverse Drug Reactions (ADRs) are an important contributor to patient morbidity and hospitalization. Spontaneous reporting of ADRs is an important tool in pharmacovigilance. Under-reporting may increase medicine-induced morbidity and mortality among patients The success of WHO International Drug Monitoring Programme is entirely dependent on the contributions of National Pharmacovigilance centres. India has  a National pharmacovigilance Centre <strong>Aim and Objectives</strong>: To determine  the  knowledge, attitude, practices of ADR reporting and f

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Rajanna, C., J. Wang, D. Zhang, et al. "The Vibrio Pathogenicity Island of Epidemic Vibrio cholerae Forms Precise Extrachromosomal Circular Excision Products." Journal of Bacteriology 185, no. 23 (2003): 6893–901. http://dx.doi.org/10.1128/jb.185.23.6893-6901.2003.

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ABSTRACT The Vibrio pathogenicity island (VPI) in epidemic Vibrio cholerae is an essential virulence gene cluster. Like many pathogenicity islands, the VPI has at its termini a phage-like integrase gene (int), a transposase-like gene (vpiT), and phage-like attachment (att) sites, and is inserted at a tRNA-like locus (ssrA). We report that the VPI precisely excises from the chromosome and that its left and right ends join to form an extrachromosomal circular excision product (pVPI). Two-stage nested PCR analysis and DNA sequencing confirmed the int-att-vpiT junction and that the core attP of pV

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Singh, Pramod K. "Importance of ionic liquid-doped solid polymer (PVPI) electrolyte." International Journal of Sustainable Energy 30, no. 5 (2011): 270–76. http://dx.doi.org/10.1080/1478646x.2010.509502.

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Kuijpers, Han C. "Is prophylactic abdominal irrigation with polyvinylpyrrolidone iodine (PVPI) safe?" Diseases of the Colon & Rectum 28, no. 7 (1985): 481–83. http://dx.doi.org/10.1007/bf02554088.

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Sergeev, E. A., B. I. Geltser, S. M. Kh Said Shokh, V. N. Kotelnikov, and E. V. Markelova. "Assessment of indicators of pulmonary volemia and systemic inflammatory response in patients with comorbidity of chronic obstructive pulmonary disease and ischemic heart disease after coronary artery bypass grafting." Bulletin Physiology and Pathology of Respiration, no. 80 (July 16, 2021): 8–17. http://dx.doi.org/10.36604/1998-5029-2021-80-8-17.

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Inroduction. Systemic inflammatory response (SIR) is an obligatory manifestation of operational stress affecting the functional status of patients, which is important to consider in persons with comorbid pathology.Aim. Evaluation of the relationship between pulmonary volemia and SIR indicators in patients with comorbidity of chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IHD) after coronary artery bypass grafting (CABG).Materials and methods. The study included 76 IHD patients aged 53 to 77 years who underwent CABG. Among the surveyed, 2 groups were identified: 39 pat

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Konda, Vijaya Chandra Reddy, Thulasi Gokul, M. Poojitha M Poojitha, and K. Umamaheswara Rao. "Adverse Events Following Immunization to CovId-19 vaccines in A Tertiary Care Hospital – A descriptive Study." Biomedical and Pharmacology Journal 14, no. 4 (2021): 2149–56. http://dx.doi.org/10.13005/bpj/2312.

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Introduction: The pandemic due to Coronavirus disease 2019 (COVID-19) is a major health issue resulting in mortality across the globe. Multiple newer medications are being tried in treatment but with minimal success. The development of vaccines is occurring with unprecedented speed using different platforms with collaborations of academia and the pharmaceutical industries globally. These vaccines are approved for emergency use authorization by health authorities based on limited data from clinical trials. Hence, there is a need for active surveillance of vaccine recipients to monitor for safet

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Soedjono, Gunanti, Eva Harlina, Antonius H. Pudjiadi, Melpa Susanti Purba, and Setyo Jatimahardhiko Widodo. "Evaluation of ventilator on lung profile of piglets (Sus scrofa) in hypovolemic shock treated with hypervolemic crystalloid resuscitation." Veterinary World 12, no. 4 (2019): 565–71. http://dx.doi.org/10.14202/vetworld.2019.565-571.

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Aim: This study was conducted to assess the effect of ventilators on the lung profile of piglets in the hypovolemic shock before and after the excessive resuscitation of the crystalloid fluid. Materials and Methods: Five male piglets were used in this study as the models of shock, and there are four phases of treatment: Stabilization, shock of bleeding, normovolemic resuscitation, and hypervolemic resuscitation. The application of mechanical ventilation to patients who suspected of having lung injury may worsen the patient's conditions. The purpose of this study was to set the ventilator with

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Maria Fernanda Pivetta Petinati, Giselle Emilãine da Silva Reis, Katheleen Miranda dos Santos, et al. "Actions about covid-19 among dentists during the first wave of the pandemic: a cross-sectional survey." RSBO 20, no. 2 (2023): 299–307. http://dx.doi.org/10.21726/rsbo.v20i2.2107.

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The transmission of viruses between species and the emergence of viral pandemics are threats to public health and with catastrophic aftermath for the population. Objective: The objective of this research was evaluated actions of Brazilian dentists concerning covid-19 during the first wave of the pandemic. Material and methods: The survey was conducted with a web-based questionnaire, from 8th July to 8th August 2020. The participants answered questions about socio-demographic factors, followed by actions towards the covid-19, that include service offered in the pandemic period, personal protect

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Rajesh, Ramwani, Khanna Malav Puja, Saini Savita, Prakash Suman Chetan, and Mathur S.K. "A Retrospective Cross Sectional Analysis of Drug Induced Diseases in A Tertiary Care Teaching Hospital Western Rajasthan." International Journal of Pharmaceutical and Clinical Research 15, no. 7 (2023): 109–13. https://doi.org/10.5281/zenodo.11553955.

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<strong>Introduction: </strong>Adverse drug reaction (ADR) has been implicated as a leading cause of considerable morbidity and mortality worldwide. The prevalence rate of ADRs has been reported to range from 0.16 to 15.7 per cent. Drug induced diseases (DIDs) are well known but least studies. Data on DIDs from India are not available. Hence, this retrospective study was conducted. <strong>Material& Methods: </strong>The present study was conducted in the department of Pharmacology, Government Medical College Kota. It was a cross sectional retrospective observational study c

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Zufnoon, Khan, Jain Neelam, and Kulsoom Abeer. "The Future of Drug Safety: India's Pharmacovigilance Programme and Emerging Smart Approaches." International Journal of Innovative Science and Research Technology (IJISRT) 10, no. 1 (2025): 2377–84. https://doi.org/10.5281/zenodo.14869985.

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Pharmacovigilance detects, evaluates, and prevents adverse drug reactions (ADRs), one of the primary avoidable causes of sickness and death. With the National Pharmacovigilance Program (NPP) and Pharmacovigilance Program of India (PvPI), pharmacovigilance has gained popularity in India to monitor medication safety and improve public health. Despite advances, ADR underreporting, healthcare professional ignorance, and infrastructural issues exist. India has used digital transformation, mobile applications, AI, and ML to improve ADR detection, real-time monitoring, and data analysis. Blockchain t

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