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Academic literature on the topic 'PVPK-30'
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Journal articles on the topic "PVPK-30"
1
Patil, Monali, Swati Waydande, and Pravin Pawar. "Design and evaluation of topical solid dispersion composite of voriconazole for the treatment of ocular keratitis." Therapeutic Delivery 10, no. 8 (2019): 481–92. http://dx.doi.org/10.4155/tde-2019-0021.
Full textAbstract:
Aim: The objective of present investigation was to increases solubility of voriconazole by using solid dispersion techniques and the development of solid dispersion-based voriconazole ophthalmic solutions. Materials & methods: The saturation solubility of solid dispersion containing polyvinylpyrrolidone K90 (PVPK-90) was found to increase the solubility of voriconazole compare other carrier like polyethylene glycol and Polyvinylpyrrolidone K 30 (PVPK-30). Solid dispersion of voriconazole was characterized by saturation solubility, Fourier-transform infrared spectroscopy and Differential scanning calorimetry study. Results & conclusion: The Fourier-transform infrared spectroscopy and Differential scanning calorimetry studies of voriconazole-based solid dispersion confirmed the complete changes in original polymorphic form of voriconazole. The antifungal assay showed that the maximum zone of inhibition was produced from optimized ophthalmic formulation containing sodium alginate as compared with other formulations and marketed eye drops.
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M., Lavanya* and A. Deevan Paul. "IMPROVEMENT OF SOLUBILITY OF CEFIXIME AND OMEPRAZOLE BY SOLID DISPERSION AND SLUGGING METHOD." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 2036–41. https://doi.org/10.5281/zenodo.834616.
Full textAbstract:
In fact, it has been estimated that 40% of new chemical entities currently being discovered are poorly watersoluble. Unfortunately, many of these potential drugs area bandoned in the early stages of development due to solubility concerns. Cefixime as per BCS classification is a class IV drug with poor solubility and poor permeability. Poor solubility of drugs leads to poor absorption and hence poor bioavailability. Omeprazole as per BCS classification is a class II drug with poor solubility and good permeability. Methods, such as salt formation, complexation with cyclodextrins, solubilization of drugs in solvent(s), and particle size reduction have also been utilized to improve the dissolution properties of poorly water-soluble drugs. Bioavailability of a drug can be increased by increasing the solubility of a drug. The % increase in saturation solubility with PVPK- 30 and urea was higher than other polymers and techniques. This shows that solid dispersion using solvent evaporation technique gives a better solubility of drug when compared to other techniques. This might be due to the better solubilization effect of drug and polymer with solvent over PEG-6000 and slugging method. Slugging method is next best alternative for solubilization of drug. Key Words: Omeprazole, Cefixime, PEG-6000, PVPK-30.
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Raturi, Ankita, Ganesh Bhatt, and Preeti Kothiyal. "FORMULATION AND EVALUATION OF NANOSUSPENSION OF ROSUVASTATIN CALCIUM." International Journal of Drug Regulatory Affairs 1, no. 3 (2018): 14–18. http://dx.doi.org/10.22270/ijdra.v1i3.115.
Full textAbstract:
Poor water solubility and slow dissolution rate are issues for majority of upcoming and existing biologically active compounds. The aim of present work was to increase the dissolution rate of Rosuvastatin Calcium, a poorly water soluble drug and hence improve its oral bioavailability by Nanosuspension technology. Nanosuspension is new carrier free colloidal drug delivery system with nano sized particles below 1000 nm, and considered as a great drug delivery technique to enhance the drug dissolution and solubility. In the present work Nanosuspension is made by nanoprecipitation technique in the presence of sodium lauryl sulfate as surfactant and PVPK-30 as stabilizer. Prepared Nanosuspension was evaluated for its particle size study, in vitro dissolution study and characterized by Screening Electron microscopy (SEM).
 Different concentrations of sodium lauryl sulphate (SLS) and PVPK-30 were evaluated. All formulations were in the nano size and showed marked improvement in dissolution and solubility compared to pure drug of micron size. Finally it was concluded that formulating poorly soluble drugs in the form of Nanosuspension would be a promising approach in delivery of poor water soluble drugs by oral route in a simple and effective way.
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Rao, Y. Madhusudan, Sunil Reddy, Panakanti Pavan Kumar, and Rajanarayana Kandagatla. "Formulation and Release Characteristic of a Bilayer Matrix Tablet Containing Glimepride Immediate Release Component and Metformin Hydrochloride as Sustained Release Component." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 1 (2010): 851–59. http://dx.doi.org/10.37285/ijpsn.2010.3.1.8.
Full textAbstract:
The aim of present study was to design the concept of bilayered tablets containing Glimepride for immediate release using sodium starch glycolate as super disintegrant and Metformin hydrochloride (HCl) for sustained release by using Hydroxyl propyl methyl cellulose (HPMC K 4M) and Sodium Carboxy Methyl cellulose (SCMC) as the matrix forming polymer, and PVPK-30 as binder. The tablets were evaluated for physicochemical properties. All the values were found to be satisfactory. In vitro release studies were carried out as per USP in pH 1.2 with (0.1% sodium lauryl sulphate w/v) and phosphate buffer pH 6.8 using the apparatus I. The release kinetics of Metformin HCl was evaluated using the regression coefficient analysis. The formulated tablets (F5) shows zero order release and diffusion was the dominant mechanism of drug release. The polymer (HPMC K4M, SCMC) and binder PVPK-30 had significant effect on the release of Metformin HCl matrix tablets (F5). Thus formulated bilayer tablets provided immediate release of Glimepride and Metformin HCl as sustained release over a period of 8 hours. Stability studies and FT-IR studies clearly indicated that there is no drug –polymer interaction.
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A.Ali, Yasser, and Shaimaa N. Abd-Alhammid. "Formulation and Evaluation of Ezetimibe Nanoparticles." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 24, no. 2 (2017): 11–21. http://dx.doi.org/10.31351/vol24iss2pp11-21.
Full textAbstract:
The aim of this study is to formulate and evaluate ezetimibe nanoparticles using solvent antisolvent technology. Ezetimibe is a practically water-insoluble drug which acts as a lipid lowering drug that selectively inhibits the intestinal absorption of cholesterol and related phytosterols. Ezetimibe prepared as nano particles in order to improve its solubility and dissolution rate.
 Thirty formulas were prepared and different stabilizing agents were used with different concentrations such as poly vinyl pyrrolidone (PVPK-30), poly vinyl alcohol (PVA), hydroxy propyl methyl cellulose E5 (HPMC), and poloxamer. The ratios of drug to stabilizers used to prepare the nanoparticles were 1: 2, 1:3 and 1:4.
 The prepared nanoparticles were evaluated for particle size, entrapment efficiency, dissolution study, Fourier transform infrared spectroscopy, differential scanning calorimetry, and atomic force microscopy. The percentage of drug entrapment efficiency of F1-F30 was ranged from 85% ± 1 to 98 % ± 1. On the other hand dissolution rate increasing as the particle surface area is increase due to reduction of particle size to the nano range.
 The results showed that poly vinyl pyrrolidone (PVPK-30) was found to be the best stabilizer.
 Keywords: Ezetimibe, Nanoparticles, Particle Size, poly vinyl alcohol.
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Shid L., Rupali, Shashikant N. Dhole, Nilesh Kulkarni, and Santosh L. Shid L. "Formulation and Evaluation of Nanosuspension Delivery System for Simvastatin." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 2 (2014): 2459–75. http://dx.doi.org/10.37285/ijpsn.2014.7.2.8.
Full textAbstract:
Poor water solubility and slow dissolution rate are issues polydispersity index. The obtained results showed that for the majority of upcoming and existing biologically active 
 particlesize (nm) and rate of dissolution has been improved compounds. Simvastatin is poorly water-soluble drug and when nanosuspension prepared with the higher its bioavailability is very low from its crystalline form. The concentration of PVPK-30 with the higher concentration of purpose of the present investigation was to increase the 
 PVP K-30 and Poloxamer-188 and lower concentration of solubility and dissolution rate of simvastatin by the SLS. The partical size and zeta potential of optimized preparation of nanosuspension by Emulsification Solvent formulation was found to be 258.3 nm and 23.43. The rate Diffusion Method at laboratory scale. Prepared nanosus- of dissolution of the optimized nanosuspension was pension was evaluated for its particle size and in vitro enhanced (90.02% in 60 min), relative to plain simvastatin dissolution study and characterized by zeta potential, (21% in 60 min), mainly due to the formation of nanosized differential scanning calorimetry (DSC) and X-Ray particles. These results indicate the suitability of 23 factorial diffractometry (XRD), motic digital microscopy, entrapment design for preparation of simvastatin loaded efficiency, total drug content, saturated solubility study and nanosuspension significantly improved in vitro dissolution in vivo study. A 23 factorial design was employed to study rate, and thus possibly enhance fast onset of therapeutic the effect of independent variables, amount of SLS (X1), drug effect. In vivo study shows increase in bioavailability in amount of PVPK-30 (X2) and Poloxamer-188 (X3) and nanosuspension formulation than the plain simvastatin dependent variables are total drug content and drug.
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Shid, Rupali L., Shashikant N. Dhole, Nilesh Kulkarni, and Santosh L. Shid. "Formulation and Evaluation of Nanosuspension of Simvastatin." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 2 (2015): 2858–73. http://dx.doi.org/10.37285/ijpsn.2015.8.2.9.
Full textAbstract:
Poor water solubility and slow dissolution rate are issues for the majority of upcoming and existing biologically active compounds. Simvastatin is poorly water-soluble drug and its bioavailability is very low from its crystalline form. The purpose of this study wasto increase the solubility and dissolution rate of simvastatin by the preparation of nanosuspension by emulsification solvent diffusion method at laboratory scale. Prepared nanosus-pension was evaluated for its particle size and in vitro dissolution study and characterized by zeta potential,differential scanning calorimetry (DSC) and X-Ray diffractometry (XRD), motic digital microscopy, entrapment efficiency, total drug content, saturated solubility study and in vivo study. A 23 factorial design was employed to study the effect of independent variables, amount of SLS (X1), amount of PVPK-30 (X2) and poloxamer-188 (X3) and dependent variables are total drug content and polydispersity Index. The obtained results showed that particle size (nm) and rate of dissolution has been improved when nanosuspension prepared with the higherconcentration of PVPK-30 with the higher concentration of PVP K-30 and Poloxamer-188 and lower concentration of SLS. The particle size and zeta potential of optimized formulation was found to be 258.3 nm and 23.43. The rate of dissolution of the optimized nanosuspension was enhanced (90% in 60min), relative to plain simvastatin (21% in 60 min), mainly due to the formation of nanosized particles. These results indicate the suitability of 23 factorial design for preparation of simvastatin loaded nano-suspension significantly improved in vitro dissolution rate and thus possibly enhance fast onset of therapeutic drug effect. In vivo study shows increase in bioavailability in nanosuspension formulation than the plain simvastatin drug.
8
Shid, Rupali L., Shashikant N. Dhole, Nilesh Kulkarni, and Santosh L. Shid. "Formulation and Evaluation of Nanosuspension Formulation for Drug Delivery of Simvastatin." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 4 (2014): 2650–65. http://dx.doi.org/10.37285/ijpsn.2014.7.4.7.
Full textAbstract:
Poor water solubility and slow dissolution rate are issues drug content and polydispersity index. The obtained for the majority of upcoming and existing biologically results showed that particle size (nm) and rate of active compounds. Simvastatin is poorly water-soluble dissolution has been improved when nanosuspension drug and its bioavailability is very low from its crystalline prepared with the higher concentration of PVPK-30 and form. The purpose of the present investigation was to Poloxamer-188 and lower concentration of SLS. The increase the solubility and dissolution rate of simvastatin by particle size and zeta potential of optimized formulation the preparation of nanosuspension by Emulsification was found to be 258.3 nm and 23.43. The rate of Solvent Diffusion Method at laboratory scale. Prepared dissolution of the optimized nanosuspension was nanosuspension was evaluated for its particle size and enhanced (90.02% in 60min), relative to plain simvastatin in vitro dissolution study and characterized by zeta (21% in 60 min), mainly due to the formation of nanosized potential, differential scanning calorimetry (DSC) and particles. These results indicate the suitability of 23 factorial X-Ray diffractometry (XRD), Motic digital microscopy, design for preparation of simvastatin loaded nanosus- entrapment efficiency, total drug content, saturated pension significantly improved in vitro dissolution rate, solubility study and in vivo study. A 23 factorial design was and thus possibly enhance fast onset of therapeutic drug employed to study the effect of independent variables, effect. In vivo study shows increase in bioavailability in amount of SLS (X1), amount of PVPK-30 (X2) and nanosuspension formulation than the plain simvastatin Poloxamer-188 (X3) and dependent variables are Total drug.
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D.V. R. N., Bhikshapathi, Vishwaja M, Suthakaran R, Usha Sri B, and M. Ratan Seshagiri Rao. "Improvement of Solubility and Dissolution Rate of Simvastatin by Solid Dispersion Technique." International Journal of Pharmaceutical Sciences and Nanotechnology 12, no. 6 (2019): 4964–700. http://dx.doi.org/10.37285/ijpsn.2019.12.6.3.
Full textAbstract:
The aim of present work is to enhance the solubility and bioavailability of Simvastatin by solid dispersion technique and characterize the same. Preliminary solubility studies were conducted to check the solubility in different polymers. Based on the results 20 formulations prepared by solvent evaporation method with varying ratios of Kleptose HPB, Soluplus, Kolliwax GMS II, Kolliphor P188 and PVPK-30. All the formulations were analyzed for solubility, percentage yield, drug content and in vitro drug release. The formulation SD20 with enhanced solubility of 20.05 ± 0.02μg/mL in Kolliwax GMS II, percentage yield of 99.13% and dissolution rate of 99.2 ± 2.3% within 90 min is chosen as optimized formulation. The formulation is further Characterized for Drug excipient interaction by FTIR, PXRD and SEM studies. The stability studies for 6 months indicated no significant changes in drug content or drug dissolution rate. Hence, improve dissolution characteristics of Simvastatin achieved by increasing its release and solubility through solid dispersion technique.
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Reddy, P. Srikanth, V. Alagarsamy, and P. Subhash Chandra Bose. "Preparation, Characterization and In Vitro Evaluation of Nanosuspension for the Treatment of Schizophrenia." International Journal of Research and Review 10, no. 11 (2023): 40–47. http://dx.doi.org/10.52403/ijrr.20231106.
Full textAbstract:
The current study aims to construct a perphenazine oral nanosuspension utilizing the solvent evaporation technique with a variety of stabilizers and surfactants, including PVPK30, Pluronic F127, urea, and SLS. In order to obtain desired size and saturation solubility, several as well as process factors were tuned. Particle size, zeta potential, saturation solubility, dissolving rate, morphological study (SEM), and in-vitro dissolution study were all used to characterize the produced Nanosuspension. The improved formulation's (F12) zeta potential value was discovered to be -7mv, which was determined to be within acceptable bounds. It was discovered that the average particle size of optimal formulations (F12) in nanosuspension was 118 nm. According to the in vitro investigations, formulation F12 exhibits the greatest 98.65% of the medication is released within 30 minutes. The drug was not released for minutes by any of the other formulations. Understanding how the release of drugs via Nanosuspension functioned was aided by the application of mathematical formulae that included zero out, and first out, method equation. R2 analysis revealed that the enhanced 1st order kinetics by F12. Keywords: Perphenazine, PVPK-30, Poloxamer 184, Pluronic F127, Urea, SLS.