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Journal articles on the topic 'PVPK-30'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Patil, Monali, Swati Waydande, and Pravin Pawar. "Design and evaluation of topical solid dispersion composite of voriconazole for the treatment of ocular keratitis." Therapeutic Delivery 10, no. 8 (2019): 481–92. http://dx.doi.org/10.4155/tde-2019-0021.

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Aim: The objective of present investigation was to increases solubility of voriconazole by using solid dispersion techniques and the development of solid dispersion-based voriconazole ophthalmic solutions. Materials & methods: The saturation solubility of solid dispersion containing polyvinylpyrrolidone K90 (PVPK-90) was found to increase the solubility of voriconazole compare other carrier like polyethylene glycol and Polyvinylpyrrolidone K 30 (PVPK-30). Solid dispersion of voriconazole was characterized by saturation solubility, Fourier-transform infrared spectroscopy and Differential sc

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2

M., Lavanya* and A. Deevan Paul. "IMPROVEMENT OF SOLUBILITY OF CEFIXIME AND OMEPRAZOLE BY SOLID DISPERSION AND SLUGGING METHOD." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 2036–41. https://doi.org/10.5281/zenodo.834616.

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In fact, it has been estimated that 40% of new chemical entities currently being discovered are poorly watersoluble. Unfortunately, many of these potential drugs area bandoned in the early stages of development due to solubility concerns. Cefixime as per BCS classification is a class IV drug with poor solubility and poor permeability. Poor solubility of drugs leads to poor absorption and hence poor bioavailability. Omeprazole as per BCS classification is a class II drug with poor solubility and good permeability. Methods, such as salt formation, complexation with cyclodextrins, solubilization

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3

Raturi, Ankita, Ganesh Bhatt, and Preeti Kothiyal. "FORMULATION AND EVALUATION OF NANOSUSPENSION OF ROSUVASTATIN CALCIUM." International Journal of Drug Regulatory Affairs 1, no. 3 (2018): 14–18. http://dx.doi.org/10.22270/ijdra.v1i3.115.

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Poor water solubility and slow dissolution rate are issues for majority of upcoming and existing biologically active compounds. The aim of present work was to increase the dissolution rate of Rosuvastatin Calcium, a poorly water soluble drug and hence improve its oral bioavailability by Nanosuspension technology. Nanosuspension is new carrier free colloidal drug delivery system with nano sized particles below 1000 nm, and considered as a great drug delivery technique to enhance the drug dissolution and solubility. In the present work Nanosuspension is made by nanoprecipitation technique in the

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4

Rao, Y. Madhusudan, Sunil Reddy, Panakanti Pavan Kumar, and Rajanarayana Kandagatla. "Formulation and Release Characteristic of a Bilayer Matrix Tablet Containing Glimepride Immediate Release Component and Metformin Hydrochloride as Sustained Release Component." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 1 (2010): 851–59. http://dx.doi.org/10.37285/ijpsn.2010.3.1.8.

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The aim of present study was to design the concept of bilayered tablets containing Glimepride for immediate release using sodium starch glycolate as super disintegrant and Metformin hydrochloride (HCl) for sustained release by using Hydroxyl propyl methyl cellulose (HPMC K 4M) and Sodium Carboxy Methyl cellulose (SCMC) as the matrix forming polymer, and PVPK-30 as binder. The tablets were evaluated for physicochemical properties. All the values were found to be satisfactory. In vitro release studies were carried out as per USP in pH 1.2 with (0.1% sodium lauryl sulphate w/v) and phosphate buff

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5

A.Ali, Yasser, and Shaimaa N. Abd-Alhammid. "Formulation and Evaluation of Ezetimibe Nanoparticles." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 24, no. 2 (2017): 11–21. http://dx.doi.org/10.31351/vol24iss2pp11-21.

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The aim of this study is to formulate and evaluate ezetimibe nanoparticles using solvent antisolvent technology. Ezetimibe is a practically water-insoluble drug which acts as a lipid lowering drug that selectively inhibits the intestinal absorption of cholesterol and related phytosterols. Ezetimibe prepared as nano particles in order to improve its solubility and dissolution rate. Thirty formulas were prepared and different stabilizing agents were used with different concentrations such as poly vinyl pyrrolidone (PVPK-30), poly vinyl alcohol (PVA), hydroxy propyl methyl cellulose E5 (HPM

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6

Shid L., Rupali, Shashikant N. Dhole, Nilesh Kulkarni, and Santosh L. Shid L. "Formulation and Evaluation of Nanosuspension Delivery System for Simvastatin." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 2 (2014): 2459–75. http://dx.doi.org/10.37285/ijpsn.2014.7.2.8.

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Poor water solubility and slow dissolution rate are issues polydispersity index. The obtained results showed that for the majority of upcoming and existing biologically active  particlesize (nm) and rate of dissolution has been improved compounds. Simvastatin is poorly water-soluble drug and when nanosuspension prepared with the higher its bioavailability is very low from its crystalline form. The concentration of PVPK-30 with the higher concentration of purpose of the present investigation was to increase the  PVP K-30 and Poloxamer-188 and lower concentration of solubility and di

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7

Shid, Rupali L., Shashikant N. Dhole, Nilesh Kulkarni, and Santosh L. Shid. "Formulation and Evaluation of Nanosuspension of Simvastatin." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 2 (2015): 2858–73. http://dx.doi.org/10.37285/ijpsn.2015.8.2.9.

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Poor water solubility and slow dissolution rate are issues for the majority of upcoming and existing biologically active compounds. Simvastatin is poorly water-soluble drug and its bioavailability is very low from its crystalline form. The purpose of this study wasto increase the solubility and dissolution rate of simvastatin by the preparation of nanosuspension by emulsification solvent diffusion method at laboratory scale. Prepared nanosus-pension was evaluated for its particle size and in vitro dissolution study and characterized by zeta potential,differential scanning calorimetry (DSC) and

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8

Shid, Rupali L., Shashikant N. Dhole, Nilesh Kulkarni, and Santosh L. Shid. "Formulation and Evaluation of Nanosuspension Formulation for Drug Delivery of Simvastatin." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 4 (2014): 2650–65. http://dx.doi.org/10.37285/ijpsn.2014.7.4.7.

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Poor water solubility and slow dissolution rate are issues drug content and polydispersity index. The obtained for the majority of upcoming and existing biologically results showed that particle size (nm) and rate of active compounds. Simvastatin is poorly water-soluble dissolution has been improved when nanosuspension drug and its bioavailability is very low from its crystalline prepared with the higher concentration of PVPK-30 and form. The purpose of the present investigation was to Poloxamer-188 and lower concentration of SLS. The increase the solubility and dissolution rate of simvastatin

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9

D.V. R. N., Bhikshapathi, Vishwaja M, Suthakaran R, Usha Sri B, and M. Ratan Seshagiri Rao. "Improvement of Solubility and Dissolution Rate of Simvastatin by Solid Dispersion Technique." International Journal of Pharmaceutical Sciences and Nanotechnology 12, no. 6 (2019): 4964–700. http://dx.doi.org/10.37285/ijpsn.2019.12.6.3.

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The aim of present work is to enhance the solubility and bioavailability of Simvastatin by solid dispersion technique and characterize the same. Preliminary solubility studies were conducted to check the solubility in different polymers. Based on the results 20 formulations prepared by solvent evaporation method with varying ratios of Kleptose HPB, Soluplus, Kolliwax GMS II, Kolliphor P188 and PVPK-30. All the formulations were analyzed for solubility, percentage yield, drug content and in vitro drug release. The formulation SD20 with enhanced solubility of 20.05 ± 0.02μg/mL in Kolliwax GMS II

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10

Reddy, P. Srikanth, V. Alagarsamy, and P. Subhash Chandra Bose. "Preparation, Characterization and In Vitro Evaluation of Nanosuspension for the Treatment of Schizophrenia." International Journal of Research and Review 10, no. 11 (2023): 40–47. http://dx.doi.org/10.52403/ijrr.20231106.

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The current study aims to construct a perphenazine oral nanosuspension utilizing the solvent evaporation technique with a variety of stabilizers and surfactants, including PVPK30, Pluronic F127, urea, and SLS. In order to obtain desired size and saturation solubility, several as well as process factors were tuned. Particle size, zeta potential, saturation solubility, dissolving rate, morphological study (SEM), and in-vitro dissolution study were all used to characterize the produced Nanosuspension. The improved formulation's (F12) zeta potential value was discovered to be -7mv, which was deter

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11

Patil, Swapnil S., Rohan D. Patil, Prakash V. Chavan, et al. "OPTIMIZATION AND CHARACTERIZATION OF FAST DISSOLVING TABLETS OF CANDESARTAN CILEXETIL PREPARED FROM SPHERICAL AGGLOMERATES." INDIAN DRUGS 61, no. 01 (2024): 46–52. http://dx.doi.org/10.53879/id.61.01.13910.

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The primary objective of this study was to develop a rapidly dissolving tablet containing an antihypertensive drug, candesartan cilexetil (CAND). The research work focused on improving solubility and in vitro dissolution of drugs using spherical agglomeration technique. Spherical agglomerates of CAND were developed using PVPK-30 as polymer and dichloromethane as bridging liquid. A spherical agglomerate of CAND was used to formulate fast dissolving tablet (FDT) with different superdisintegrants like Crospovidone and Cross carmellose sodium. The prepared powder blend was evaluated for different

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12

Pradyumna Chaudhari, Shanti Saran Koiri, Ashish Lamsal, and Roshan Kumar Mehta. "Formulation and Evaluation of Fast Disintegrating Tablet of Salbutamol Sulphate." Journal of Universal College of Medical Sciences 12, no. 02 (2024): 29–33. http://dx.doi.org/10.3126/jucms.v12i02.69619.

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INTRODUCTION When put on the tongue, fast dissolving tablets immediately dissolve, often in a matter of seconds. They do not need any additional water to make them easier to swallow. Salbutamol sulphate fast disintegrating tablets have a higher bioavailability and dissolving rate. MATERIAL AND METHODS This experimental study was conducted in the Pharmaceutic laboratory of Department of Pharmacy at Universal College of Medical Sciences, Bhairahawa, Nepal from February 2022 to July 2022. A tablet was created utilizing the direct compression method employing mannitol as a diluent and various quan

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13

Sohrab, Mohd, S. P. Mahapatra, and Shashank Tiwari. "Enhancement of Dissolution Rate of Aceclofenac by Formation of Aceclofenac-Nicotinic Acid Cocrystal using Water Soluble Polymers like PVPK-30, HPMCE5, SSG and Na-CMC." Indo Global Journal of Pharmaceutical Sciences 05, no. 03 (2015): 154–70. http://dx.doi.org/10.35652/igjps.2015.01.

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14

Challa, Taraka Ramarao, and Pathivada SaiKiranmai. "DESIGN AND DEVELOPMENT OF ANTI-INFLAMMATORY DRUG NAPROXEN SOLID DISPERSIONS AND FORMULATIONS BY FACTORIAL DESIGN APPROACH." Suranaree Journal of Science and Technology 30, no. 6 (2024): 070071(1–11). http://dx.doi.org/10.55766/sujst-2023-06-e01216.

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Naproxen is a non-steroidal anti-inflammatory (NSAID) drug that can be used as an analgesic, anti-inflammatory, and antipyretic. Objectives: The study’s major goal was to improve the drug’s solubility and dissolution rate, as well as its oral bioavailability. Methods: Physical mixture, kneading process, and solvent evaporation method were used to make Naproxen solid dispersions (SDs). Using a two-level factorial design and three independent components, X1 β-Cyclodextrin, X2: Kolliphor p-188, and X3: PVPK-30 and designed by a Design expert (DOE). The formulation was studied by flow parameters,

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15

Saroj, Neetishwar, Preeti Rawat, Priyanka Rathour, Lokesh Mani Saroj, and Rajesh Kumar. "Preparation and Evaluation of Sustained Release Colon Targeted Micropellets of Lornoxicam." Pharmaceutical Methods 8, no. 2 (2017): 75–80. https://doi.org/10.5281/zenodo.14856396.

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The aim of the present work was to develop and evaluate sustained release colon targeted micropellets of lornoxicam in order to achieve release of the drug at colon which could result in enhanced local absorption and thereby improved bio-availability. The present worker prepared micropellets of lornoxicam in nine batches using pure drug, DCP, PVPK-30 and different ratios of HPMCK-4M taking into account the direct pelletization technique. Resulted micropellets were fiilled in capsules and coated with eudragit S-100 to achieve colon targeted release. Compatibility studies were by using FTIR and

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16

Gawshinde, Arpit Gawshinde. "Formulation, development and evaluation of paracetamol tablet by moisture activated dry granulation (MADG) process." Journal of Pharmaceutical and Biological Sciences 12, no. 1 (2024): 60–67. http://dx.doi.org/10.18231/j.jpbs.2024.010.

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Paracetamol, also known as acetaminophen, is a painkiller that is popular throughout the world because it does not irritate the stomach. Paracetamol was first discovered to have both analgesic and antipyretic properties in the late nineteenth century. The aim of present work was to Formulate, develop and evaluate Paracetamol Tablets by Moisture Activated Dry Granulation (MADG) process to short manufacturing time and process variables as compared with convention process. Colloidal anhydrous silica is used in the formulation to absorb the extra moisture present in the MADG process formulation. A

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17

Mohammed, Ihsan A., and Fatima J. Al-Gawhari. "Formulation, Characterization, Optimization, and In-vitro Evaluation of Rosuvastatin as Nanofiber." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 04 (2023): 1258–66. http://dx.doi.org/10.25258/ijddt.13.4.22.

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Bioavailability is the objective for an optimum formulation. The target of the analysis is to maximize both the fluidity and disintegration profile of class II weakly compounds that are water-soluble. Anti-dyslipidemia drug rosuvastatin calcium (RC) (bioavailability 20%) through formulating as nanofibers (NFs) using electrospinning (ES) technology. Twenty formulas were prepared, and different polymers and polymer combinations with various concentrations were used such as polyethylene oxide (PEO) polyvinyl pyrrolidine (PVPK-30), and hydroxypropyl methylcellulose (HPMC). Three distinct groups of

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18

Reddy G., Govinda, Rakesh Kumar Jat, and K. M. Manjanna. "Formulation and Evaluation of Pulsatile drug delivery of Albuterol sulphate and Theophylline drugs using modified Pulsincap technology." Journal of Drug Delivery and Therapeutics 14, no. 2 (2024): 127–33. http://dx.doi.org/10.22270/jddt.v14i2.6383.

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Albuterol Sulphate and Theophylline are used as anti-asthma agents. The objective of the present investigation was to design develop and evaluate a modified pulsincap drug delivery system of Albuterol Sulphate and Theophylline for the treatment of Asthma. The body of capsule was made insoluble with water by cross linking with formaldehyde. This modified capsule was completely filled with drug with polymer such as HPMCK15M, HPMC K 100M, PVPK-30 to expel the drug after predetermined lag time. A hydrogel plug was inserted in the body of a capsule to obtain desired drug release after a lag time fo

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19

Gulabrao Bhamare, Vaibhav, and Ravindra Keshavrao Kamble. "Modified Solubility of Etodolac through Solid Dispersion and Complexation." Research Journal of Pharmacy and Technology, February 26, 2022, 683–88. http://dx.doi.org/10.52711/0974-360x.2022.00113.

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Solubility and dissolution is an essential requirement for any drug to perform well in vivo. The present research was undertaken to enhance the dissolution rate of poor water soluble drug Etodolac through solid dispersion and complexation technique. Fusion method and kneading methods were employed for solubility enhancement by Solid Dispersion technique and complexation technique respectively. PEG-6000, HPMC K4M, β-Cyclodextrin and PVPK-30 are used as carriers. Physical mixtures were prepared in different ratio of drug and carriers. The prepared blends were evaluated for solubility, drug conte

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G. Prajapati, Bhupendra, Himanshu Paliwal, and Mayuree Patel. "Fabrication and Evaluation of Polymeric Nanoparticles of Acitretin for the Solubility Enhancement." Research Journal of Pharmacy and Technology, June 26, 2023, 2655–60. http://dx.doi.org/10.52711/0974-360x.2023.00436.

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The present study was an attempt to prepare nanoparticle of Acitretin which is used in Psoriasis. The preparation of nanoparticles was done by precipitation method employing several blends of polymers such as PVPK 30, PVPK 90, Poloxamer 407 and Poloxamer 188. The oral nanoparticles were characterized for various physicochemical parameters, such as particle size analysis, drug-excipient interactions, zeta potential, saturated solubility, XRD study, in-vitro drug release, FTIR spectroscopic studies displayed that there were not any interactions between drug and excipients. The nanoparticle batch

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21

Arora, Harpreet Singh, Taranjit Kaur, Rajesh Kumar, Amar Pal Singh, and Singh Singh. "Preparation and evalution of sustained release matrix tablet of nitrofurantoin." International Journal of Pharmaceutics and Drug Analysis, February 19, 2025, 10–16. https://doi.org/10.47957/ijpda.v13i1.616.

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In the present study an attempt was made to Preparation and Evaluation of Sustained Release Matrix Tablet of Nitrofurantoin by wet granulation method using various polymers like HPMC 4000 & PVPK 30 Materials and Methods A variety of physicochemical characteristics, including rheological characteristics, weight variation, thickness, hardness, in vitro release studies, and drug content, were assessed for the prepared tablets. Results All of the physicochemical parameters met the official standards, according to studies. The extended release profile of the formulation, which has better bioava

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22

Sreedhar, Ranjan Das Bibhuti Bhusan Panigrahi And Manoj Kumar Pani. "DEVELOPMENT AND OPTIMIZATION OF BI LAYERED FLOATING TABLET OF SUCRALFATE AND METOPROLOL SUCCINATE." May 25, 2019. https://doi.org/10.5281/zenodo.3273878.

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Objective:To optimize and develop Bi layered floating tablet (SFMS) containing ulcer protective Sucralfate as immediate release layer and anti hypertensiveMetoprolol Succinate as sustained release layer. Method: 15 formulations of Sucralfate and 10 formulations of Metoprolol Succinate is taken. By changing the concentration of Superdisintigrant, Surfectants, Alkalizing agents & Binding agents of Sucralfate and changing concentrations of Alkalizing agents and Polymers of Metoprolol Succinate the OSFMS (Optimized Sucralfate and Metoprolol Succinate Formulation) is generated.. Result: Within

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23

Aftaab, Kapil Kumar, Vaishali Chauhan, Ikram, and Vaishali Rajput. "Development and evaluation of matrix type transdermal patches of Simvastatin." International Journal of Indigenous Herbs and Drugs, October 24, 2023, 40–47. http://dx.doi.org/10.46956/ijihd.v8i5.489.

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Transdermal patches are a cutting-edge drug delivery technology, as it avoids first-pass metabolism results in increased bioavailability and aid in the delivery of drug molecules into the systemic circulation at predetermined and controlled rate. Aim behind this invention was to formulate a stable, reproducible and non-infringing & examine matrix-type transdermal patches of Simvastatin by using solvent evaporation method and the formulation consist various polymer including HPMC, Ethyl Cellulose, Chitosan, PVPK-30 and Eudragit RS 100, plasticizers like glycerine, propylene glycol, an

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24

S. Patel, Sanajy, Gayatri C. Patel, and Chirag S. Patel. "Development of Liposomal Encapsulated Silver Sulfadiazine Gel for Burn Therapy." Research Journal of Pharmaceutical Dosage Forms and Technology, August 5, 2023, 175–83. http://dx.doi.org/10.52711/0975-4377.2023.00029.

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The aim of the present study was to formulate stable silver sulfadiazine (SSD) liposomal gel suitable for topical delivery with a view to increase bactericidal activity in burn therapy. SSD liposomes were formulated using thin film hydration technique. A 23 factorial design was utilized to study the effect of the molar ratio of lipid: cholesterol (X1), drug concentration (X2) and hydration volume on Encapsulation efficiency (EE%) and vesicle size. Selected batch of liposome was incorporated in to PVPK-30 and HPMCK4M gel base to prepare the liposomal gel formulation, which was evaluated for in-

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25

Lekshmi, Sethu, Therase Jose, Manju Maria Mathews, and Badmanaban R. "Formulation and evaluation of topical gels incorporated with solid dispersions of an antiinflammatory drug." Journal of Innovations in Applied Pharmaceutical Science (JIAPS), November 30, 2023, 114–19. http://dx.doi.org/10.37022/jiaps.v8i3-s.536.

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Formulation and development of a most effective product from poorly soluble drugs is one of the most challenging tasks in pharmaceutical industries. Solid dispersion is an efficient solubility enhancement method to overcome the solubility problem. The aim of this study was to formulate topical gels incorporated with solid dispersion of Aceclofenac to enhance permeability through the skin. Aceclofenac solid dispersions were prepared using suitable hydrophilic carriers to increase its aqueous solubility. In this study, solid dispersions of Aceclofenac were prepared by solvent evaporation and co-

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