Relevant bibliographies by topics / Pwwp

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Academic literature on the topic 'Pwwp'

Author: Grafiati
Published: 4 June 2021
Last updated: 14 February 2022

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Journal articles on the topic "Pwwp"

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Wang, Rui, Jie Gao, Jiahai Zhang, Xuecheng Zhang, Chao Xu, Shanhui Liao, and Xiaoming Tu. "Solution structure of TbTFIIS2-2 PWWP domain from Trypanosoma brucei and its binding to H4K17me3 and H3K32me3." Biochemical Journal 476, no. 2 (January 31, 2019): 421–31. http://dx.doi.org/10.1042/bcj20180870.

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Abstract Posttranslational modifications (PTMs) of core histones, such as histone methylation, play critical roles in a variety of biological processes including transcription regulation, chromatin condensation and DNA repair. In T. brucei, no domain recognizing methylated histone has been identified so far. TbTFIIS2-2, as a potential transcription elongation factors in T. brucei, contains a PWWP domain in the N-terminus which shares low sequence similarity compared with other PWWP domains and is absent from other TFIIS factors. In the present study, the solution structure of TbTFIIS2-2 PWWP domain was determined by NMR spectroscopy. TbTFIIS2-2 PWWP domain adopts a global fold containing a five-strand β-barrel and two C-terminal α-helices similar to other PWWP domains. Moreover, through systematic screening, we revealed that TbTFIIS2-2 PWWP domain is able to bind H4K17me3 and H3K32me3. Meanwhile, we identified the critical residues responsible for the binding ability of TbTFIIS2-2 PWWP domain. The conserved cage formed by the aromatic amino acids in TbTFIIS2-2 PWWP domain is essential for its binding to methylated histones.
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Chen, Taiping, Naomi Tsujimoto, and En Li. "The PWWP Domain of Dnmt3a and Dnmt3b Is Required for Directing DNA Methylation to the Major Satellite Repeats at Pericentric Heterochromatin." Molecular and Cellular Biology 24, no. 20 (October 15, 2004): 9048–58. http://dx.doi.org/10.1128/mcb.24.20.9048-9058.2004.

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ABSTRACT Dnmt3a and Dnmt3b are responsible for the establishment of DNA methylation patterns during development. These proteins contain, in addition to a C-terminal catalytic domain, a unique N-terminal regulatory region that harbors conserved domains, including a PWWP domain. The PWWP domain, characterized by the presence of a highly conserved proline-tryptophan-tryptophan-proline motif, is a module of 100 to 150 amino acids found in many chromatin-associated proteins. However, the function of the PWWP domain remains largely unknown. In this study, we provide evidence that the PWWP domains of Dnmt3a and Dnmt3b are involved in functional specialization of these enzymes. We show that both endogenous and green fluorescent protein-tagged Dnmt3a and Dnmt3b are particularly concentrated in pericentric heterochromatin. Mutagenesis analysis indicates that their PWWP domains are required for their association with pericentric heterochromatin. Disruption of the PWWP domain abolishes the ability of Dnmt3a and Dnmt3b to methylate the major satellite repeats at pericentric heterochromatin. Furthermore, we demonstrate that the Dnmt3a PWWP domain has little DNA-binding ability, in contrast to the Dnmt3b PWWP domain, which binds DNA nonspecifically. Collectively, our results suggest that the PWWP domains of Dnmt3a and Dnmt3b are essential for targeting these enzymes to pericentric heterochromatin, probably via a mechanism other than protein-DNA interactions.
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Qiu, Yu, Wen Zhang, Chen Zhao, Yan Wang, Weiwei Wang, Jiahai Zhang, Zhiyong Zhang, et al. "Solution structure of the Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA." Biochemical Journal 442, no. 3 (February 24, 2012): 527–38. http://dx.doi.org/10.1042/bj20111885.

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Methylation of H4K20 (Lys20 of histone H4) plays an important role in the regulation of diverse cellular processes. In fission yeast, all three states of H4K20 methylation are catalysed by Set9. Pdp1 is a PWWP (proline-tryptophan-tryptophan-proline) domain-containing protein, which associates with Set9 to regulate its chromatin localization and methyltransferase activity towards H4K20. The structure of the Pdp1 PWWP domain, which is the first PWWP domain identified which binds to methyl-lysine at the H4K20 site, was determined in the present study by solution NMR. The Pdp1 PWWP domain adopts a classical PWWP fold, with a five-strand antiparallel β-barrel followed by three α-helices. However, it differs significantly from other PWWP domains in some structural aspects that account, in part, for its molecular recognition. Moreover, we revealed a unique binding pattern of the PWWP domain, in that the PWWP domain of Pdp1 bound not only to H4K20me3 (trimethylated Lys20 of histone H4), but also to dsDNA (double-stranded DNA) via an aromatic cage and a positively charged area respectively. EMSAs (electrophoretic mobility-shift assays) illustrated the ability of the Pdp1 PWWP domain to bind to the nucleosome core particle, and further mutagenesis experiments indicated the crucial role of this binding activity in histone H4K20 di- and tri-methylation in yeast cells. The present study may shed light on a novel mechanism of histone methylation regulation by the PWWP domain.
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Slater, Leanne M., Mark D. Allen, and Mark Bycroft. "Structural Variation in PWWP Domains." Journal of Molecular Biology 330, no. 3 (July 2003): 571–76. http://dx.doi.org/10.1016/s0022-2836(03)00470-4.

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Tan, Hong Kee, Chan-Shuo Wu, Jia Li, Zi Hui Tan, Jordan R. Hoffman, Christopher J. Fry, Henry Yang, Annalisa Di Ruscio, and Daniel G. Tenen. "DNMT3B shapes the mCA landscape and regulates mCG for promoter bivalency in human embryonic stem cells." Nucleic Acids Research 47, no. 14 (June 20, 2019): 7460–75. http://dx.doi.org/10.1093/nar/gkz520.

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Abstract DNMT3B is known as a de novo DNA methyltransferase. However, its preferential target sites for DNA methylation are largely unknown. Our analysis on ChIP-seq experiment in human embryonic stem cells (hESC) revealed that DNMT3B, mCA and H3K36me3 share the same genomic distribution profile. Deletion of DNMT3B or its histone-interacting domain (PWWP) demolished mCA in hESCs, suggesting that PWWP domain of DNMT3B directs the formation of mCA landscape. In contrast to the common presumption that PWWP guides DNMT3B-mediated mCG deposition, we found that deleting PWWP does not affect the mCG landscape. Nonetheless, DNMT3B knockout led to the formation of 2985 de novo hypomethylated regions at annotated promoter sites. Upon knockout, most of these promoters gain the bivalent marks, H3K4me3 and H3K27me3. We call them spurious bivalent promoters. Gene ontology analysis associated spurious bivalent promoters with development and cell differentiation. Overall, we found the importance of DNMT3B for shaping the mCA landscape and for maintaining the fidelity of the bivalent promoters in hESCs.
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Shun, Ming-Chieh, Yaïr Botbol, Xiang Li, Francesca Di Nunzio, Janet E. Daigle, Nan Yan, Judy Lieberman, Marc Lavigne, and Alan Engelman. "Identification and Characterization of PWWP Domain Residues Critical for LEDGF/p75 Chromatin Binding and Human Immunodeficiency Virus Type 1 Infectivity." Journal of Virology 82, no. 23 (September 17, 2008): 11555–67. http://dx.doi.org/10.1128/jvi.01561-08.

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ABSTRACT Lens epithelium-derived growth factor (LEDGF)/p75 functions as a bimodal tether during lentiviral DNA integration: its C-terminal integrase-binding domain interacts with the viral preintegration complex, whereas the N-terminal PWWP domain can bind to cellular chromatin. The molecular basis for the integrase-LEDGF/p75 interaction is understood, while the mechanism of chromatin binding is unknown. The PWWP domain is homologous to other protein interaction modules that together comprise the Tudor clan. Based on primary amino acid sequence and three-dimensional structural similarities, 24 residues of the LEDGF/p75 PWWP domain were mutagenized to garner essential details of its function during human immunodeficiency virus type 1 (HIV-1) infection. Mutating either Trp-21 or Ala-51, which line the inner wall of a hydrophobic cavity that is common to Tudor clan members, disrupts chromatin binding and virus infectivity. Consistent with a role for chromatin-associated LEDGF/p75 in stimulating integrase activity during infection, recombinant W21A protein is preferentially defective for enhancing integration into chromatinized target DNA in vitro. The A51P mutation corresponds to the S270P change in DNA methyltransferase 3B that causes human immunodeficiency, centromeric instability, and facial anomaly syndrome, revealing a critical role for this amino acid position in the chromatin binding functions of varied PWWP domains. Our results furthermore highlight the requirement for a conserved Glu in the hydrophobic core that mediates interactions between other Tudor clan members and their substrates. This initial systematic mutagenesis of a PWWP domain identifies amino acid residues critical for chromatin binding function and the consequences of their changes on HIV-1 integration and infection.
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Qin, Su, and Jinrong Min. "Structure and function of the nucleosome-binding PWWP domain." Trends in Biochemical Sciences 39, no. 11 (November 2014): 536–47. http://dx.doi.org/10.1016/j.tibs.2014.09.001.

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Ge, Ying-Zi, Min-Tie Pu, Humaira Gowher, Hai-Ping Wu, Jian-Ping Ding, Albert Jeltsch, and Guo-Liang Xu. "Chromatin Targeting ofde NovoDNA Methyltransferases by the PWWP Domain." Journal of Biological Chemistry 279, no. 24 (March 3, 2004): 25447–54. http://dx.doi.org/10.1074/jbc.m312296200.

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Kibe, Kanako, Kenjiro Shirane, Hiroaki Ohishi, Shuhei Uemura, Hidehiro Toh, and Hiroyuki Sasaki. "The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes." PLOS Genetics 17, no. 5 (May 28, 2021): e1009570. http://dx.doi.org/10.1371/journal.pgen.1009570.

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DNA methylation at CG sites is important for gene regulation and embryonic development. In mouse oocytes, de novo CG methylation requires preceding transcription-coupled histone mark H3K36me3 and is mediated by a DNA methyltransferase DNMT3A. DNMT3A has a PWWP domain, which recognizes H3K36me2/3, and heterozygous mutations in this domain, including D329A substitution, cause aberrant CG hypermethylation of regions marked by H3K27me3 in somatic cells, leading to a dwarfism phenotype. We herein demonstrate that D329A homozygous mice show greater CG hypermethylation and severer dwarfism. In oocytes, D329A substitution did not affect CG methylation of H3K36me2/3-marked regions, including maternally methylated imprinting control regions; rather, it caused aberrant hypermethylation in regions lacking H3K36me2/3, including H3K27me3-marked regions. Thus, the role of the PWWP domain in CG methylation seems similar in somatic cells and oocytes; however, there were cell-type-specific differences in affected regions. The major satellite repeat was also hypermethylated in mutant oocytes. Contrary to the CA hypomethylation in somatic cells, the mutation caused hypermethylation at CH sites, including CA sites. Surprisingly, oocytes expressing only the mutated protein could support embryonic and postnatal development. Our study reveals that the DNMT3A PWWP domain is important for suppressing aberrant CG hypermethylation in both somatic cells and oocytes but that D329A mutation has little impact on the developmental potential of oocytes.
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Zhang, Mengmeng, Ming Lei, Su Qin, Aiping Dong, Ally Yang, Yanjun Li, Peter Loppnau, Timothy R. Hughes, Jinrong Min, and Yanli Liu. "Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains." Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1864, no. 3 (March 2021): 194688. http://dx.doi.org/10.1016/j.bbagrm.2021.194688.

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Dissertations / Theses on the topic "Pwwp"

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Botbol, Yaïr. "Rôle de LEDGF/p75 au cours de l'intégration du VIH-1 dans la chromatine,et ciblage de l'intégration vers l'hétérochromatine." Paris 6, 2009. http://www.theses.fr/2009PA066703.

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L’intégration est une étape clé du cycle réplicatif du VIH-1 catalysée par l’intégrase virale, impliquant in vivo de nombreuses protéines virales et cellulaires dont LEDGF/p75. Ce cofacteur interagit directement avec l’intégrase, stimule fortement l’intégration et est indispensable à une infection productive. Dans la cellule, l’intégration cible l’ADN empaqueté dans la chromatine. Nous avons mis au point un essai d’intégration in vitro sur matrice chromatine qui a mis en évidence le rôle du domaine PWWP pour la stimulation de l'intégration dépendante de LEDGF. Nous avons de plus caractérisé les éléments structuraux de LEDGF et de ce domaine impliqués dans son interaction avec la chromatine et favorisant l’activité de LEDGF au cours de l’intégration. Ce système a permis de corréler des données in vitro avec celles obtenue sur l'effet de LEDGF au cours de l'infection par le VIH-1. Dans une seconde partie, nous avons mis au point une stratégie de ciblage de l’intégration vers des régions d’hétérochromatine. Nous avons donc construit des intégrases chimériques par fusion à l’intégrase de VIH-1 de domaines protéiques reconnaissant des motifs hétérochromatiniens. Nos résultats montrent le maintien d’une activité d’intégration de ces enzymes in vitro et in vivo. De plus, l’intégration d’un gène rapporteur apporté par ces virions subit une extinction progressive de son expression, caractéristique de l’effet négatif de variégation lié à la propagation de l’hétérochromatine environnante. Cependant, cet effet peut être levé en flanquant le transgène de séquence insulatrice. Ces résultats ouvrent des perspectives pour la réduction de la génotoxicité des vecteurs rétroviraux.
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Hohenstatt, Mareike L. [Verfasser]. "Functional Analysis of SCI1 - A PWWP domain protein involved in Polycomb group mediated gene regulation in Arabidopsis / Mareike L. Hohenstatt." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2012. http://d-nb.info/1023946963/34.

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Morchikh, Mehdi. "Identification de nouveaux partenaires du domaine PWWP de LEDGF/p75 et mise au point d'un essai cellulaire permettant d'étudier l'interaction entre l'intégrase du VIH-1 et LEDGF/p75." Paris 6, 2012. http://www.theses.fr/2012PA066332.

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L’intégration est une étape clé du cycle réplicatif du VIH-1 catalysée par l’intégrase rétrovirale. Cette étape est la cible de nouveaux inhibiteurs incorporés dans les traitements antiviraux mais l’apparition de souches virales résistantes à ces inhibiteurs conduit à rechercher de nouvelles molécules inhibitrices de cette étape. L’intégrase du VIH-1 interagit avec de nombreux cofacteurs cellulaires dont la protéine LEDGF/p75 qui est essentielle à la réplication virale. Elle stimule les activités catalytiques de l’intégrase et participe à la sélectivité d’intégration. LEDGF/p75 interagit avec l’intégrase et la chromatine via ses domaines IBD et PWWP respectivement. Mon projet a pour but d’identifier de nouvelles molécules antivirales ciblant ces deux interactions. Mes travaux de thèse m’ont tout d’abord permis d’identifier cinq séquences peptidiques cellulaires appelées PBDs (PWWP Binding Domain) interagissant avec le domaine PWWP de LEDGF/p75. La validation de ces PBDs a été effectuée par un test de complémentation protéique dans les cellules humaines, basé sur une restauration d’activité de deux domaines inactifs de la luciférase de Gaussia princeps. Deux de ces PBDs sont très prometteurs en raison de leur capacité à fixer la protéine entière du LEDGF/p75 et de leur incapacité à interagir avec des mutants de cette protéine ne fixant plus la chromatine et n’activant plus l’intégration dans cette structure cellulaire. Dans une seconde partie, j’ai établi un essai permettant de mesurer l’interaction entre l’intégrase et LEDGF/p75 directement dans les cellules. Cet essai permettra de réaliser un criblage haut débit afin d’identifier de nouvelles molécules antivirales bloquant cette interaction. Les résultats obtenus au cours de ma thèse permettent donc de proposer de nouvelles stratégies anti-VIH-1 ciblant des interactions protéiques essentielles entre ce virus et la cellule infectée
Integration is an essential step of the HIV-1 retroviral replication cycle catalysed by the viral integrase. Integrase inhibitors are undergoing clinical trials, but viruses resistant to these inhibitors have already emerged. Therefore, new integrase targets need to be identified, such as cellular integrase partners. One of them, the lens epithelium-derived growth factor (LEDGF/p75), is essential for HIV-1 replication. This protein interacts with both integrase and chromatin by his IBD and PWWP domains respectively. The purpose of my project was to identify new antiviral molecules targeting these two interactions. First, I have identified five peptides sequences interacting with the PWWP domain of the LEDGF/p75 (called PWWP Binding Domains or PBD). I have confirmed these interactions in 293T cells by a Protein Complementation Assay (PCA) based on the restored activity of two inactive fragments of the Gaussia princeps luciférase. Two PBDs are very promising due to their ability to interact with the full-length LEDGF/p75 protein and their inability to interact with LEDGF/p75 PWWP mutants affected by chromatin interaction and LEDGF-dependant activation of integration. The second part of my PhD program, I was involved in the establishment of a new assay that allowed the quantification of the LEDGF/p75 – HIV-1 integrase interaction directly in cells. This assay will be used to perform a high-throughput screen to identify new inhibitors of this interaction. Results obtained during my PhD allow the proposal new anti-HIV strategies targeting essential protein-protein interactions between this virus and infected cells
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Mikulski, Pawel [Verfasser]. "The analysis of PWWP INTERACTOR OF POLYCOMBS 1 (PWO1), a putative link between Polycomb-mediated repression and nuclear : Evolutionary studies of Polycomb-mediated repression in the unicellular algae / Pawel Mikulski." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1129685691/34.

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Mikulski, Pawel Slawomir [Verfasser]. "The analysis of PWWP INTERACTOR OF POLYCOMBS 1 (PWO1), a putative link between Polycomb-mediated repression and nuclear : Evolutionary studies of Polycomb-mediated repression in the unicellular algae / Pawel Mikulski." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1129685691/34.

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Huo, Zhao. "A Comparsion of Multiple Imputation Methods for Missing Covariate Values in Recurrent Event Data." Thesis, Uppsala universitet, Statistiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-256602.

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Multiple imputation (MI) is a commonly used approach to impute missing data. This thesis studies missing covariates in recurrent event data, and discusses ways to include the survival outcomes in the imputation model. Some MI methods under consideration are the event indicator D combined with, respectively, the right-censored event times T, the logarithm of T and the cumulative baseline hazard H0(T). After imputation, we can then proceed to the complete data analysis. The Cox proportional hazards (PH) model and the PWP model are chosen as the analysis models, and the coefficient estimates are of substantive interest. A Monte Carlo simulation study is conducted to compare different MI methods, the relative bias and mean square error will be used in the evaluation process. Furthermore, an empirical study based on cardiovascular disease event data which contains missing values will be conducted. Overall, the results show that MI based on the Nelson-Aalen estimate of H0(T) is preferred in most circumstances.
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Ghiassi-Razavi, Hediyih. "The expanded public works programme : a strategy for poverty alleviation and job creation." Diss., University of Pretoria, 2012. http://hdl.handle.net/2263/29645.

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In the context of the high unemployment and poverty rates in South Africa, this research was undertaken to explore the best practices of successful international public works programmes (PWPs) around the world. The aim was to develop a strategy for poverty alleviation and job creation with respect to the infrastructure sector of the Expanded Public Works Programme (EPWP) in South Africa. The purpose of the EPWP is to make the unemployed more employable through offering beneficiaries temporary employment and training opportunities. In the literature review, the strategy for poverty alleviation and job creation was formulated in terms of the design elements and implementation aspects of PWPs. This strategy was then used to evaluate the infrastructure sector of the EPWP. The data collection took the form of interviews with key informants who are directly involved with the infrastructure sector of the EPWP. The nature of the enquiry was qualitative, with narrative and content analysis used to explore the data. The research found that, overall, the design elements and the implementation aspects of the infrastructure sector of the EPWP are not appropriate for enabling the unemployed to become more employable on a large scale. Based on the international best practices, recommendations were then put forward as improvements which would enable the infrastructure sector of the EPWP to achieve its objectives more effectively.
Dissertation (MBA)--University of Pretoria, 2012.
Gordon Institute of Business Science (GIBS)
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Santos, Odilanei Morais dos. "Lobbying na regulação contábil e qualidade da informação: evidências do setor petrolífero." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/12/12136/tde-15042013-131336/.

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O presente trabalho teve como objetivo principal identificar os fatores determinantes à adoção de estratégias de lobbying sobre a regulação contábil do setor petrolífero, bem como avaliar a qualidade das informações contábeis das empresas desse setor. Para atender a esse objetivo, recorreu-se a três estudos direcionados para cada um dos seguintes aspectos: determinantes do lobbying e características dos grupos de interesses (estudo 1); estágio atual da qualidade da informação contábil do setor petrolífero (estudo 2) e evidências empíricas às questões do Discussion Paper Extractive Activities (estudo 3). Para operacionalizar os estudos, utilizaram-se as cartas comentários enviadas ao IASB e a base de dados da Evaluate Energy®, empregando-se diversas técnicas econométricas como regressão linear simples e múltipla, regressão logística binomial e multinomial e regressão de Poisson a diversos planos amostrais contendo informações de empresas petrolíferas. Os resultados indicam que o grupo de interesse formado pelos preparadores de demonstrações financeiras do setor petrolífero possui incentivos econômicos para realizar lobbying sobre determinada regulamentação contábil no sentido de defender seus interesses como prega a teoria da regulação econômica, notadamente quanto ao fator tamanho. Tal grupo de interesse, dentro do plano das escolhas contábeis, é favorável à utilização do custo histórico como base de valor e da possibilidade de escolha entre dois modelos contábeis concorrentes (successful efforts e full cost) e desfavoráveis às mudanças que levem ao aumento do nível de divulgação das informações. Suportando essa posição, tem-se a visão dos usuários primários das demonstrações financeiras que sugerem que as informações contábeis disponibilizadas pelas empresas petrolíferas são de qualidade, ao menos sob o prisma da relevância e conservadorismo, e indicam, ainda, que o atual conjunto de informações baseado no custo histórico é relevante para as suas decisões econômicas. Levando-se em consideração o grande apoio recebido pela proposta de ampliação das divulgações obrigatórias, aí incluída a proposta do Publish What You Pay, tem-se a rejeição por parte dos participantes do mercado de capitais indicando que os benefícios decorrentes da ampliação da divulgação não serão maiores do que os existentes, considerando as regras atuais. Em contraponto, tem-se a concepção de que a informação contábil produzida pelas empresas petrolíferas é inoportuna. Nesse particular, não se vislumbram alterações nessa constatação uma vez que a proposta de um novo modelo contábil de reconhecimento apresentada no DPEA se aproxima do método full cost, enquanto que as evidências do segundo estudo apontam para direção contrária ao sugerir que o método successful efforts gera informações mais oportunas do que o método concorrente. Assim, tem-se um cenário para se acreditar na manutenção do status quo vigente.
This paper aimed to identify the determining factors for the adoption of lobbying strategies regarding the accounting regulation of the oil sector, as well as to assess the quality of the accounting information of the companies from this sector. To meet these goals, three studies directed to each of the underlined aspects were used: determinants of the lobbying and characteristics of the interest groups (study 1); current status of the quality of accounting information from the oil sector (study 2) and empirical evidence for the questions of Discussion Paper Extractive Activities (study 3). To operationalize the studies, letters and comments sent to the IASB and the database of Evaluate Energy® were deployed, through the use of several econometric techniques such as simple and multiple linear regressions, binomial and multinomial logistic regression and Poisson regression in various sampling plans featuring information of the oil companies. The results indicate that the interest group formed by preparers of financial statements for the oil sector has economic incentives to undertake lobbying for an accounting regulation, in the sense of defending their interests according to the economic regulation theory, notably when size is taken into account. This interest group, within the plane of accounting choices, is in favor of using the historical cost as a basis of value and of the possibility of choice between two competitor accounting models (successful efforts and full cost) and unfavorable to the changes that lead to the increase of the disclosure level of the information. Supporting this position, there is the view of the primary users of financial statements that suggests that the accounting information provided by oil companies is valuable, at least from the perspective of relevance and conservatism, and indicates, yet, that the current group of information based on the historical cost is relevant to their economic decisions. Considering the huge support received by the proposal to expand the required disclosures, therein included the proposal of Publish What You Pay, there is rejection by the participants of the capital market indicating that the benefit resulting from the expansion of the disclosure shall not be greater than those already in existence, considering the current rules. In contrast, there is the view that the accounting information produced by oil companies is untimely. In this, particularly, alterations in this finding are not envisaged once the proposal of the new accounting model of recognition presented at DPEA approaches the full cost method, whereas evidence of the second study points to the opposite direction by suggesting that the successful efforts method generates more appropriate information than does the current method. Therefore, there is scenario to believe in the maintenance of the present status quo.
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Hill, Timothy D. "Relationships among language use, phonological skill, and vocabulary in English language learning preschoolers." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002575.

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Reddy, Bharat. "Elucidating the Biological Function of PWWP-Domain Containing Protein Complexes." Thesis, 2013. https://doi.org/10.7916/D81V5N5Z.

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In eukaryotes, nuclear DNA is folded with histone proteins in the form of chromatin, and this structure plays a critical role in multiple biological processes, including development, DNA damage repair, and aging. Post-translational modifications of histones, such as acetylation and methylation, are essential regulators of chromatin structure and function. Consequently, misregulation of these post-translational modifications has causal roles in numerous diseases, including multiple types of cancer. However, the mechanisms that direct the localization of histone-modifying enzymes and regulate their activities are not fully understood. This thesis focuses on the characterization of a class of proteins containing the PWWP domain. This domain is often present in chromatin proteins, and it is predicted to recognize methylated histones based on structural analysis. Here, we have demonstrated that the PWWP domain proteins in fission yeast bind to methylated histones. Additionally, we have shown that proteins with this domain form complexes with diverse histone modifying activities to regulate multiple cellular processes. Methylation of histone H4 lysine 20 (H4K20me) is essential for the activation of a DNA damage checkpoint, which blocks the progression of cell cycle to allow sufficient time for DNA damage repair. In fission yeast, only the enzyme Set9 catalyzes H4K20me, and the mechanisms that underlie the regulation of this protein are poorly characterized. Here we showed that Set9 forms a stable complex with the PWWP domain containing protein Pdp1. The PWWP domain of Pdp1 binds to H4K20me, demonstrating that the PWWP domain constitutes a novel methyl-lysine recognition motif. Moreover, the binding of PWWP domain to methylated H4K20 plays a critical role in regulating Set9 activity, thus facilitating higher degrees of H4K20 methylation. Histone H3K9 methylation is critical for heterochromatin assembly in diverse organisms. The RNAi pathway is required for the formation of pericentric heterochromatin, although the exact role that RNAi plays in heterochromatin assembly remains a topic of significant debate. We discovered that a separate PWWP domain protein, Pdp3, forms a stable complex with the H3K14 histone acetyltransferase Mst2. Interestingly eliminating the enzymatic activity of the Pdp3-Mst2 complex obviates the requirement for the RNAi machinery in pericentric heterochromatin functions. Furthermore we demonstrated that one function of RNAi during heterochromatin assembly is to exclude the Pdp3-Mst2 complex, thus maintaining low levels of RNA polymerase II localization to pericentric regions in order to retain the parental histone modification patterns for its passage through generations. Altogether, my results have firmly demonstrated that the PWWP domain is a novel class of methyl-lysine binding motifs. Moreover, in fission yeast the PWWP domain proteins form stable complexes with other chromatin proteins to regulate diverse cellular processes.
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Books on the topic "Pwwp"

1

Lindsay, Karen. Genetic characterisation of the regulatory genes of TOL plasmid pWWO. Birmingham: Universityof Birmingham, 1987.

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Kulesza, Juliusz. Reduta PWPW: Polska Wytwórnia Papierów Wartościowych w konspiracji i w Powstaniu Warszawskim. Warszawa: Instytut Wydawniczy Pax, 1989.

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Montana. Legislature. Office of the Legislative Auditor. Performance audit report, Department of Social and Rehabilitation Services: Project Work Program (PWP) [and] Job Opportunities and Basic Skills (JOBS) Program. Helena, Mont. (Rm. 135, State Capitol, Helena 59620): The Office, 1993.

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Kalfatovic, Martin R. The New Deal fine arts projects: A bibliography, 1933-1992. Metuchen, N.J: Scarecrow Press, 1994.

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Books, Golden. Batman Gnt Pww. Golden books, 1991.

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Books, Golden. Christmas Gnt Pww. Golden books, 1991.

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Books, Golden. Fern Gully Pww Bk. Golden books, 1991.

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PWP: Plot? What Plot? Dare 2 Dream Publishing, 2003.

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Books, Golden. Tiny Toons Giant Pww. Golden books, 1990.

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Books, Golden. Swamp Thing Pww Bk. Golden books, 1991.

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Book chapters on the topic "Pwwp"

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Xu, Chao, Gaofeng Cui, Maria Victoria Botuyan, and Georges Mer. "Methyllysine Recognition by the Royal Family Modules: Chromo, Tudor, MBT, Chromo Barrel, and PWWP Domains." In Histone Recognition, 49–82. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-18102-8_3.

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Chechik, Marsha, Jocelyn Simmonds, Sotirios Liaskos, Shiva Nejati, Mehrdad Sabetzadeh, and Rick Salay. "PWWM: A Personal Web Workflow Methodology." In Lecture Notes in Computer Science, 11–48. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-39995-4_2.

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Dössereck, C., and M. Reuss. "Reaktionstechnische Untersuchungen zur konjugativen Übertragung des TOL-Plasmids pWWO in Suspension und im Biofilm." In Ökologie der Abwasserorganismen, 123–33. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61423-1_9.

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Kumar, Shiv Shankar, A. Murali Krishna, and Arindam Dey. "Dynamic Properties and PWP Model Parameters of Sandy Soil for Ground Response Analysis." In Lecture Notes in Civil Engineering, 737–49. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-6564-3_61.

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Helali, Wafa, Zied Hajaiej, and Adnen Cherif. "Hybrid Feature Extraction Techniques Using TEO-PWP for Enhancement of Automatic Speech Recognition in Real Noisy Environment." In Proceedings of the 1st International Conference on Smart Innovation, Ergonomics and Applied Human Factors (SEAHF), 190–95. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-22964-1_20.

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"PWP." In Wörterbuch GeoTechnik/Dictionary Geotechnical Engineering, 865. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-33335-4_162160.

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Cole, Allan Hugh. "Living with an Illness Called Parkinson’s." In Counseling Persons with Parkinson's Disease, 53–81. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780190672928.003.0004.

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This chapter considers three matters. First, it explains how a counselor best becomes familiar with the experiences and needs of persons with Parkinson’s (PwP) by using a phenomenological approach to counseling. Second, the chapter details the nature of living with Parkinson’s, including the condition’s wide-ranging effects on quality of life. Third, the chapter shows how counselors may work with PwP using a time-limited approach after understanding the fundamental nature of Parkinson’s and what it requires in the way of supportive care. The loss-based counseling (LBC) approach is introduced. Finally, perhaps most crucial for the book as a whole, the chapter presents an argument for why thinking in terms of a person having an illness, as opposed to a disease, is most helpful. Specifically, a focus on disease prioritizes the objective physiological state, whereas a focus on illness prioritizes a person’s subjective experience of living with the disease.
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Cole, Allan Hugh. "Beginning." In Counseling Persons with Parkinson's Disease, 1–12. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780190672928.003.0001.

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Through personal narrative, this chapter details the author’s experience of first becoming aware that something was not right with his body. This experience leads to visiting his primary care doctor who tells him that she is concerned about the possibility of his having Parkinson’s disease and then refers the author to a neurologist who is a movement disorder specialist. He is examined by this neurologist, who says, “What worries me is that I think you are in the early stages of Parkinson’s disease,” but who wants the author to have a brain scan that will confirm the clinical diagnosis given his young age and subtle symptoms. The author leaves his office, drives home, and informs his wife that this doctor thinks he have Parkinson’s disease. Here begins his new life as a person with Parkinson’s (PwP).
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Tullís, B. "Measurement of Particles From Equipment and Processes: The Particles-Per-Wafer-Per Pass (Pwp) Method." In Particle Control for Semiconductor Manufacturing, 211–42. Routledge, 2018. http://dx.doi.org/10.1201/9780203744307-13.

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White, Robert E. "Soil Quality in Vineyards." In Soils for Fine Wines. Oxford University Press, 2003. http://dx.doi.org/10.1093/oso/9780195141023.003.0009.

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The soil must provide a favorable physical environment for the growth of vines—their roots and beneficial soil organisms. Some of the important properties con­tributing to this condition are infiltration rate, soil strength, available water ca­pacity, drainage, and aeration. Ideally, the infiltration rate IR should be >50 mm/hr, allowing water to enter the soil without ponding on the surface, which is predisposed to runoff and erosion. The range of infiltration rates for soils of different texture and structural condi­tion is shown in table 7.1. Typically, the soil aggregates should have a high de­gree of water stability so that when the soil is subjected to pressure from wheeled traffic or heavy rain, the aggregates do not collapse, nor do the clays deflocculate. Some of the problems associated with the collapse of wet aggregates and clay de-flocculation, and the formation of hard surface crusts when dry, are discussed in section 3.2.3. Pans that develop at depth in the soil profile, as a result of remolding of wet aggregates under wheel or cultivation pressure, can be barriers to root growth. Soil strength is synonymous with consistence, which is the resistance by the soil to deformation when subjected to a compressive shear force (box 2.2). Soil strength depends on the soil matrix potential m and bulk density BD, as illustrated in fig­ure 7.1. In situ soil strength is best measured using a penetrometer, as discussed in box 7.1. The soil strength at a ψm of −10 kPa (FC ) should be <2 MPa for easy root penetration and should not exceed 3 MPa at –1500 kPa (PWP). As shown in figure 7.1, when ψm is between −10 and −100 kPa, the soil strength increases with BD. The BD of vineyard soils can increase, particularly in the inter-row areas because of compaction by machinery, such as tractors, spray equip­ment, and harvesters. Typically, compaction occurs at depths between 20 and 25 cm and is more severe in sandy soils than in clay loams and clays (except when the clays are sodic; see section 7.2.3). Figure 7.2 shows the marked difference in soil compaction, measured by penetration resistance, under a wheel track and un­der a vine row on a sandy soil in a vineyard.
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Conference papers on the topic "Pwwp"

1

Liu, Gang, Zeng-Quan YANG, and Stephen P. Ethier. "Abstract 3102: Oncogenic PWWP-domain protein WHSC1L1 links the homeobox transcription factor IRX3 in breast cancer." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3102.

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Chen, Chun-Jung, and Li-Jin Hsu. "Abstract 2758: Domain swapping and SMYD1 interactions with the PWWP domain of human hepatoma-derived growth factor." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2758.

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Chen, Chun-Jung, and Li-Jin Hsu. "Abstract 2758: Domain swapping and SMYD1 interactions with the PWWP domain of human hepatoma-derived growth factor." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2758.

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Yu, Xin-Guo, Ki-Yong Choi, Chul-Hwa Song, Istvan Trosztel, Ivan Toth, and Gyorgy Ezsol. "MARS-KS Code Analysis of the Pressure Wave Propagation Test 0 Performed at the PMK-2 Test Facility." In 2014 22nd International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/icone22-30658.

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The pressure waves might be expected in the nuclear reactor systems due to sudden rupture of a pipe, quick opening or closure of a system valve. If generated, they can result in large mechanical loads on the RPV internal structures and pipelines, threating their integrity. This kind of phenomena is an important issue and a limiting accident case for the nuclear power plant safety, which requires extensive analysis to ensure the nuclear power plant safety. To study these phenomena, four PWP (Pressure Wave Propagation) tests have been performed in the PMK-2 test facility in MTA EK. In addition, these tests have been used to assess the capability of the MARS-KS code in simulating the PWP phenomena. Then, an input model representing the PMK-2 test facility was developed to simulate the tests. The MARS-KS simulation results are then compared with the test results. The comparison shows that the MARS code can well simulate the PWP frequencies and the initial pressure peaks as well. After the qualified assessment, the MARS-KS code is then deployed to conduct the sensitivity analysis on the effect of the break size, break time, coolant initial conditions on the PWP phenomena. The sensitivity analysis on the break sizes shows that the pressure wave amplitude is relevant to the break times: the shorter the break opening time is, the faster the pressure. The sensitivity analysis on the break sizes shows that the larger the break size is, the higher the pressure peak is.
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Yan Hao, Bibo Tu, Jianfeng Zhan, and Dan Meng. "PWP: a cluster Web portal based on MVC." In Eighth International Conference on High-Performance Computing in Asia-Pacific Region (HPCASIA'05). IEEE, 2005. http://dx.doi.org/10.1109/hpcasia.2005.81.

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Hole, Stephane, and Jacques Lewiner. "Characterization of semiconducting structures by the PWP method." In 2008 13th International Symposium on Electrets ISE 13. IEEE, 2008. http://dx.doi.org/10.1109/ise.2008.4813999.

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Ibrahim, Gusri Akhyar, Che Hassan Che Haron, Che Husna Azhari, M. A. Wahid, S. Samion, N. A. C. Sidik, and J. M. Sheriff. "Sustainable Rural Energy: Traditional Water Wheels in Padang (PWW) Indonesia." In THE 10TH ASIAN INTERNATIONAL CONFERENCE ON FLUID MACHINERY. AIP, 2010. http://dx.doi.org/10.1063/1.3464893.

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Short, Robert E., Duke Littlejohn, and Ronald Driggers. "An update on PWP enhancement for LWIR target acquisition sensors." In Infrared Imaging Systems: Design, Analysis, Modeling, and Testing XXX, edited by Keith A. Krapels and Gerald C. Holst. SPIE, 2019. http://dx.doi.org/10.1117/12.2519088.

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Cheng, Lin, Lisheng Zhong, Yue Zhang, Shitian Tan, and Jingliang Chen. "A Piezo-PWP method for charge measurement of the cell suspension." In 2009 IEEE 9th International Conference on the Properties and Applications of Dielectric Materials (ICPADM). IEEE, 2009. http://dx.doi.org/10.1109/icpadm.2009.5252243.

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Hole, S., L. A. Dissado, J. C. Fothergill, and J. Lewiner. "Direct analysis of heterogeneous insulators with the PWP and the PEA methods." In 2008 13th International Symposium on Electrets ISE 13. IEEE, 2008. http://dx.doi.org/10.1109/ise.2008.4814054.

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Reports on the topic "Pwwp"

1

Yang, Zeng-Quan. Histone Code Modulation by Oncogenic PWWP-Domain Protein in Breast Cancers. Fort Belvoir, VA: Defense Technical Information Center, August 2014. http://dx.doi.org/10.21236/ada611736.

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Yang, Zeng-Quan. Histone Code Modulation by Oncogenic PWWP-domain Protein in Breast Cancers. Fort Belvoir, VA: Defense Technical Information Center, June 2012. http://dx.doi.org/10.21236/ada564161.

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Yang, Zeng-Quan. Histone Code Modulation by Oncogenic PWWP-domain Protein in Breast Cancers. Fort Belvoir, VA: Defense Technical Information Center, June 2013. http://dx.doi.org/10.21236/ada584664.

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Yang, Zeng-Quan. Histone Code Modulation by Oncogenic PWWP-Domain Protein in Breast Cancers. Fort Belvoir, VA: Defense Technical Information Center, June 2010. http://dx.doi.org/10.21236/ada547591.

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