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Dissertations / Theses on the topic 'Pylori therapy'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Unge, Peter. "Pharmacological therapy of Helicobacter pylori infection /." Linköping : Univ, 2002. http://www.bibl.liu.se/liupubl/disp/disp2002/med734s.pdf.

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2

Millson, Charles Edward. "Photodynamic therapy for the treatment of helicobacter pylori infection." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281686.

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3

Silva, Fernando Marcuz. "Reinfecção pelo Helicobacter pylori em pacientes brasileiros com úlcera péptica, em seguimento de 5 anos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5147/tde-01092009-135137/.

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Introdução: A reinfecção pelo Helicobacter pylori em países em desenvolvimento parece ser maior do que nos países desenvolvidos. O retratamento da bactéria e o controle periódico de cura são necessários, quando elevadas taxas de reinfecção são verificadas. O objetivo do trabalho foi determinar a taxa anual de reinfecção, em pacientes brasileiros com úlcera péptica, num seguimento de cinco anos. Métodos: Pacientes com úlcera péptica, diagnosticada por endoscopia digestiva alta e infecção pelo Helicobacter pylori documentada por histologia, teste da urease, reação em cadeia da polimerase e teste

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4

Morgner, Andrea, Ekkehard Bayerdörffer, Christian Thiede, et al. "Bedeutung der Helicobacter-pylori-Infektion für die Pathogenese und Therapie von MALT-Lymphomen des Magens." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-134075.

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Seit 1983 ist das Konzept des Mukosa-assoziierten lymphatischen Gewebes (MALT) im Magen auf dem Boden einer chronischen Helicobacter(H.)-pylori-Infektion bekannt. Viele epidemiologische, biologische und molekulargenetische Studien haben die Rolle von H. pylori in der Lymphomgenese unterstützt. Bis heute wurden weltweit mehr als 650 Patienten mit gastralem MALT-Lymphom und H.-pylori-Infektion antibiotisch behandelt. Bei etwa 75% der Fälle kann mit Hilfe dieser Therapie eine komplette Lymphomremission induziert werden. Klinische prädiktive Faktoren helfen dabei, Patienten bezüglich ihres Risikos

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5

Yu, Di. "Adenovirus for Cancer Therapy : With a Focus on its Surface Modification." Doctoral thesis, Uppsala universitet, Klinisk immunologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-203662.

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Adenovirus serotype 5 (Ad5) is widely used as an oncolytic agent for cancer therapy. However, its infectivity is highly dependent on the expression level of coxsackievirus-adenovirus receptor (CAR) on the surface of tumor cells. We engineered Ad5 virus with the protein transduction domain (PTD) from the HIV-1 Tat protein (Tat-PTD) inserted in the hypervariable region 5 (HVR5) of the hexon protein in the virus capsid. Tat-PTD-modified Ad5 shows a dramatically increased transduction level of CAR-negative cells and bypassed fiber-mediated transduction. It also overcomes the fiber-masking problem,

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6

Morgner, Andrea, Ekkehard Bayerdörffer, Christian Thiede, et al. "Bedeutung der Helicobacter-pylori-Infektion für die Pathogenese und Therapie von MALT-Lymphomen des Magens." Karger, 2002. https://tud.qucosa.de/id/qucosa%3A27560.

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Seit 1983 ist das Konzept des Mukosa-assoziierten lymphatischen Gewebes (MALT) im Magen auf dem Boden einer chronischen Helicobacter(H.)-pylori-Infektion bekannt. Viele epidemiologische, biologische und molekulargenetische Studien haben die Rolle von H. pylori in der Lymphomgenese unterstützt. Bis heute wurden weltweit mehr als 650 Patienten mit gastralem MALT-Lymphom und H.-pylori-Infektion antibiotisch behandelt. Bei etwa 75% der Fälle kann mit Hilfe dieser Therapie eine komplette Lymphomremission induziert werden. Klinische prädiktive Faktoren helfen dabei, Patienten bezüglich ihres Risikos

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7

Hiroi, Shinzo. "Impact of health insurance coverage for Helicobacter pylori gastritis on the trends in eradication therapy in Japan: retrospective observational study and simulation study based on real world data." Kyoto University, 2018. http://hdl.handle.net/2433/232454.

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8

Barbuti, Ricardo Correa. ""Doença do refluxo gastroesofágico: influência da cepa cagA do Helicobacter pylori na resposta terapêutica à inibição da bomba protônica em pacientes com esofagite erosiva leve"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5147/tde-02062006-164352/.

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Foram estudados 83 pacientes com esofagite erosiva graus I e II, pela classificação de Savary-Miller modificada, divididos em 3 grupos. Um sem Helicobacter pylori, dois outros com Helicobacter pylori, com e sem o gene cagA. Avaliou-se a participação da bactéria e de seu gene cagA, associados à estudo histopatológico de antro e corpo e à gastrinemia basal, na cicatrização da mucosa do esôfago após tratamento com pantoprazol 40 mg ao dia por 6 semanas. Verificou-se que a presença do Helicobacter pylori, independentemente da presença do gene cagA, facilita a cicatrização esofágica. Indivíduos com

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9

Rosania, Rosa [Verfasser], Ulrich [Gutachter] Peitz, and Peter [Gutachter] Konturek. "Helicobacter pylori eradication therapy is not associated with the onset of inflammatory bowel disease : a case-control study / Rosa Rosania ; Gutachter: Ulrich Peitz, Peter Konturek." Magdeburg : Universitätsbibliothek Otto-von-Guericke-Universität, 2020. http://d-nb.info/1219965499/34.

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10

Nordenstedt, Helena. "Gastroesophageal reflux : etiological factors /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-205-7/.

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11

Poltronieri-Oliveira, Ayla Blanco [UNESP]. "Efeito da infecção e da terapia de erradicação da Helicobacter pylori na expressão gênica de paciente com gastrite crônica." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/136231.

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Submitted by Ayla Blanco Poltronieri null (aylinha_bp@hotmail.com) on 2016-03-11T02:05:30Z No. of bitstreams: 1 Dissertação Pós Defesa.pdf: 1526886 bytes, checksum: b50424a42154b92cbde06c084bf0975d (MD5)<br>Approved for entry into archive by Sandra Manzano de Almeida (smanzano@marilia.unesp.br) on 2016-03-14T12:33:21Z (GMT) No. of bitstreams: 1 poltronierioliveira_ab_me_sjrp.pdf: 1526886 bytes, checksum: b50424a42154b92cbde06c084bf0975d (MD5)<br>Made available in DSpace on 2016-03-14T12:33:21Z (GMT). No. of bitstreams: 1 poltronierioliveira_ab_me_sjrp.pdf: 1526886 bytes, checksum: b50424a4

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12

Fritz, Nicola Elke. "Helicobacter-pylori-Diagnostik und -Therapie in der Routineversorgung eine Umfrage unter Ärzten und Patienten zur Evaluierung der nationalen Leitlinie /." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=962075582.

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13

Kroettinger, Annett. "Effektivität der neuen 7-Tage-Tripel-Therapie mit Esomeprazol, Rifabutin und Amoxicillin bei Infektionen mit Makrolid- und Imidazolresistenten Helicobacter pylori Stämmen." Diss., lmu, 2002. http://nbn-resolving.de/urn:nbn:de:bvb:19-6893.

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14

Kühn, Andreas. "Effektivität der verkürzten 4 Tage PPI-Triple-Therapie mit Esomeprazol, Clarithromycin und Amoxicillin bei Infektionen mit bekannter Antibiotika-Sensitivität von Helicobacter pylori." Diss., lmu, 2002. http://nbn-resolving.de/urn:nbn:de:bvb:19-121649.

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15

Huang, Chung-Huan, and 黃仲歡. "The development of nanoparticles for Helicobacter pylori eradication therapy." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/ydq9q4.

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碩士<br>國立臺灣大學<br>醫學工程學研究所<br>106<br>Helicobacter pylori (H. pylori) infection is the main cause of gastritis, gastroduodenal ulcers and gastric cancer. H. pylori eradication has been shown to have a prophylactic effect against gastric cancer. However, the long treatment time, large single dose of drug, and side effects of eradication therapy often lead to treatment failure. In this study, the magnetic nanoparticles combined with chitosan and polyacrylic acid (PAA) is used as a drug nanoparticle for H. pylori eradication therapy. The muco-adhesive property of chitosan allows nanoparticles to adh

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16

You, Shih-Lin, and 游士璘. "Cost-effectiveness Analysis of Empirical Eradication Therapy of H. pylori." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/95080065683669343116.

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碩士<br>高雄醫學大學<br>臨床藥學研究所碩士班<br>95<br>The aim of this study was to compare the cost-effectiveness of the “empirical eradication” strategy of H. pylori and the “traditional” strategy in patients with active non-complicated peptic ulcer disease over a period of one year. The numerous evidences have assessed the role of Helicobacter pylori (H. pylori) in the pathogenesis of gastric ulcers and duodenal ulcers. And there is a great decrease of ulcer recurrence after H. pylori eradication from 67% to 6% and 59% to 4% in patients with duodenal ulcers and gastric ulcers, respectively. Additionally, th

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17

Shih, Chih-An, and 石志安. "Hybrid Therapy Versus Triple Therapy in The First Line Treatment of Helicobacter Pylori Infection: A Cost-Effectiveness Analysis." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/55626335635156919285.

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碩士<br>高雄醫學大學<br>醫務管理暨醫療資訊學系碩士在職專班<br>105<br>Background Helicobacter pylori is a major cause to develop gastritis and peptic ulcer, and gastric cancer. The infection rate could be up to 80% in developing countries, and the infection rate in Taiwan is 54%. Therefore, treatment regimens for H. pylori are especially important. According to the Maastricht III Consensus Report in 2005, the first-line treatment to eradicate H. pylori is using triple therapy with a 7- to 14-day course of regimen. Unfortunately, because of the increased resistant in H. pylori, the aforementioned treatment has more than

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18

Chua, Chian Sem, and 蔡儉心. "The Adjuvant Effects of Berry Extract on Triple Therapy for Helicobacter pylori Eradication." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/06051311907760908100.

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碩士<br>臺北醫學大學<br>保健營養學研究所<br>99<br>Helicobacter pylori (H. pylori) was found in 70-90% of the population in developing countries and in 25-50% of developed countries. H. pylori is the major risk factors of gastritis, gastric ulcers, duodenal ulcers, mucosa associated lymphoid tissue lymphoma (MALToma) and gastric cancer. One-week of triple therapy is currently regarded as the gold standard for H. pylori eradication. However, the eradication rate continues to be disappointing. Large dosages of antibiotic treatment during eradication of H. pylori may induce a change in the bowel flora and lead ga

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19

Moravcová, Monika. "Rezistence kmenů Helicobacter pylori na antimikrobiální léčbu." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-304059.

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Helicobacter pylori (hereinafter referred to as H. pylori) is a gram-negative bacteria which colonises the human stomach mucosa. Its role in the aethiopathogenesis of chronic gastritis, ulcer disorders of the gastroduodenum and MALT-lymphoma has been clearly demonstrated, and in connection with the occurrence of stomach cancer it has been indicated by the World Health Organisation (WHO) as a class I carcinogen. H. pylori infection can be detected from samples of stomach mucosa taken in an endoscopic examination (rapid urease test, microscopic examination, culture), or the non-invasive method c

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20

Kuo, Chao-Hung, and 郭昭宏. "The possible pathogenesis of Helicobacter pylori-induced gastrointestinal disease based on Mongolian gerbil’s model and The rescue therapy for Helicobacter pylori infection." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/72198088672626036212.

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博士<br>高雄醫學大學<br>醫學研究所<br>97<br>Since the isolation and culture of Helicobacter pylori in 1983, this germ has been accepted as an important human pathogen for the development of gastritis, peptic ulcer, and gastric cancer. In 1994, WHO designated H. pylori as Class I carcinogen. Therefore, management of H. pylori infection is an important medical issue. Helicobacter pylori eradication rate following triple therapy is decreasing worldwide. It may be due to high antibiotics resistance rate and the adoption of Bismuth-containing regimens become popularly accepted as the second-line therapy. Howeve

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21

"Laparoscopic surgery and eradication of helicobacter pylori in the treatment strategy for perforated duodenal ulcer." 1999. http://library.cuhk.edu.hk/record=b6073221.

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by Enders Kwok Wai Ng.<br>Thesis (M.D.)--Chinese University of Hong Kong, [1999].<br>Includes bibliographical references (p. 178-203).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.

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22

"The role of UreF dimerisation in urease maturation." 2012. http://library.cuhk.edu.hk/record=b5549217.

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預激活綜合體的形成對於脲酶的成熟是必需的。所以作為預激活綜合體一部份，UreF/UreG/UreG綜合體的形成也是脲酶成熟的關鍵之一。從幽門螺桿菌UreF/UreH的晶體結構顯示出是一個由異源二聚體形成的二聚體，這UreF/UreH二聚體和幽門螺桿菌的脲酶都有擁有個獨特的二重對稱性。而UreF/UreH二聚體的長度和幽門螺桿菌脲酶獨特的二次軸上那兩個催化中心的距離很接近。這讓我們聯想到UreF/UreH二聚體的二聚化是否與脲酶的活性有關。所以跟據UreF/UreH的晶體結構，計計了三個証實可以破壞UreF二聚化的突變體(F33D/Q37A, R179A/Y183D and F33D/Q37A/R179A/Y183D)。而這些突變體與UreH的結合體都保留了和脲酶結舍的能力卻失去了和UreG結合的能力，所以都不可以結合成完整的預激活綜合體來熟化脲酶。為了UreF/UreH二聚面的虛擬篩選，AutoDock Vina和Dock6.5,這兩個篩選程式用了DUD去做了一些基準。而基於一個百分比的富集值和首個已知配體的百分比值， Dock6.5比AutoDock Vina優勝，所以會用Dock6.5來篩選可以綁定UreF的二聚分介面的分子。最後，分析Dock6.5前1排名的分子，這些分子可以跟據它們和UreF殘基的接觸分類。<br>The formation of the pre-activ

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23

"Cathelicidin is a host defense peptide in controlling helicobacter pylori survival and infection." 2013. http://library.cuhk.edu.hk/record=b5549720.

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幽門螺桿菌感染在世界範圍內普遍存在，超過50%的世界人口都曾被感染。幽門螺桿菌與胃炎，胃潰瘍，胃癌和其他胃內疾病的發生密切相關。盡管目前已有多種有效除菌的抗生素，但耐藥菌的出現仍然不可忽視。防止幽門螺桿菌感染能有效的減緩疾病進程及其相關疾病引發的死亡率。因此，新藥物或者新的藥物劑型的研發十分重要。<br>Cathelicidin是一種宿主免疫防禦系統用於抵抗不同種類病原微生物感染的生物肽。然而，其在幽門螺桿菌感染引發的炎癥中的作用仍未被揭示。本研究旨在發現Cathelicidin在幽門螺桿菌體內及體外感染中的可能抗菌作用及其機制。為了研究不同劑量Cathelicidin對幽門螺桿菌的直接抗菌作用，我們主要觀察了細菌生長，生物膜形成及細菌形態的改變。實驗結果表明，Cathelicidin可有效的抑制幽門螺桿菌的生長，破壞其生物膜形成，及在細菌胞膜形成孔狀結構，以改變其正常的超微形態。<br>在宿主抵禦幽門螺桿菌感染的機制中，自噬不僅具有抗菌活性，同時在清除胃上皮細胞內病原體的方面發揮著重要作用。然而，幽門螺桿菌則可能得益於自噬通路，並掌控自噬這一工具，進而幫助其自身的存活及感染。<br>研究發現，維生素D於體內的活性形式1,25 - 二羥維生素D3（1,25D3）可促進Cathelicidin的合成及激活自噬通路，從而發揮自身免疫來殺死在胃上皮細胞內定植的幽門螺桿菌。此外，通過RNA

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Huang, JingChuen, and 黃靖淳. "Impact of intravenous omeprazole on Helicobacter pylori eradication by triple therapy in patients with peptic ulcer bleeding." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/31849992531908377592.

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碩士<br>國立成功大學<br>臨床藥學研究所<br>88<br>Background Bleeding is a common but serious complication of peptic ulcer disease. The lethality of the first ulcer bleeding is 0.5-4 %, and an increase of 16-29 % has been observed in cases of rebleeding. There are two options to diminish the rebleeding risk of ulcer: the first, medical prevention with omeprazole, H2-antagonists, and antacid use; the second, prophylaxis of recurrent bleeding episodes by H. pylori eradication. However, there is still a lack of therapeutic options for H. pylori infection during acute ulcer bleeding, which could be star

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25

Ferreira, Marilia Pires. "Terapêutica Híbrida como tratamento de 1ª linha na erradicação de Helicobacter pylori." Master's thesis, 2020. http://hdl.handle.net/10316/97801.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Introdução e objetivos: A erradicação da infeção por Helicobacter pylori adquiriu especial relevância desde que se percebeu o seu impacto no tratamento e prevenção das complicações a que se associa, nomeadamente a doença ulcerosa péptica e as neoplasias gástricas. A par disso, o atual contexto de crescente resistência antimicrobiana torna prioritário encontrar novas soluções terapêuticas que permitam reduzir a taxa de insucesso da sua eliminação. Este estudo propôs-se, nesse sentido, a avaliar a eficácia do

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Silva, Rute Maria Amado da. "Evaluation of the antimicrobial potential of natural extracts on Helicobacter pylori." Master's thesis, 2020. http://hdl.handle.net/10316/94048.

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Dissertação de Mestrado em Bioquímica apresentada à Faculdade de Ciências e Tecnologia<br>Helicobacter pylori é uma bactéria Gram-negativa, microaerofílica e patogénica. Coloniza o epitélio gástrico, podendo induzir infeção graças a uma série de mecanismos de adaptação que desenvolveu ao coevoluir com os seres humanos. Estima-se que mais de metade da população mundial esteja infetada, com maior incidência nos países em desenvolvimento. A infeção é geralmente adquirida durante a infância e desenvolvida durante a idade adulta, dependendo da relação bactéria-hospedeiro e da patogenicidade dos seu

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27

Jin, Chuan. "Improvement of adoptive T-cell therapy for Cancer." Doctoral thesis, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300210.

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Cancer immunotherapy has recently made remarkable clinical progress. Adoptive transfer of T-cells engineered with a chimeric antigen receptor (CAR) against CD19 has been successful in treatment of B-cell leukemia. Patient’s T-cells are isolated, activated, transduced with a vector encoding the CAR molecule and then expanded before being transferred back to the patient. However some obstacles restrict its success in solid tumors. This thesis explores different aspects to improve CAR T-cells therapy of cancer. Ex vivo expanded T-cells are usually sensitive to the harsh tumor microenvironment aft

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Huang, Shu-Fen, and 黃淑芬. "A Randomized Open Trial for Comparison of Proton Pump Inhibitors, Esomeprazole versus Omeprazole, in Triple Therapy for Helicobacter pylori Infection." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/97065507987471241108.

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碩士<br>國立成功大學<br>臨床藥學研究所<br>91<br>Background: It is well established that infection with Helicobacter pylori is the important cause of peptic ulcer, and eradication of this organism not only causes regression of the associated gastritis but also enhances curing of the disease. Based on numerous management guidelines, the most proper eradication approach is triple therapy, with one anti-secretory agent in combination with two antibiotics. Esomeprazole is the S-isomer of omeprazole and the first proton pump inhibitor to be developed as an optical isomer. In Europe countries and America, esomepra

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29

Campos, Daniela Priscila Rodrigues Lopes de. "Improvement of the current therapy against Helicobacter pylori: biophysical studies of drug-membrane interactions and development of a drug delivery system." Doctoral thesis, 2018. https://hdl.handle.net/10216/113604.

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30

Campos, Daniela Priscila Rodrigues Lopes de. "Improvement of the current therapy against Helicobacter pylori: biophysical studies of drug-membrane interactions and development of a drug delivery system." Tese, 2018. https://hdl.handle.net/10216/113604.

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31

Baumann, Nicola. "Diagnostische Nachweisverfahren für Helicobacter pylori im Vergleich: Prospektive Untersuchung bei 132 Patienten der Universitätsmedizin Göttingen." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F02F-3.

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32

Borody, Thomas Julius Prof. "Development of novel therapies for gut dysbioses." Thesis, 2016. http://hdl.handle.net/10453/52985.

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University of Technology Sydney. Faculty of Science.<br>This thesis reports results of 30 years of systematic clinical investigations carried out by the author in the general area of “infection-driven inflammation”. The Centre for Digestive Diseases (CDD) endoscopy clinic was founded by the author in 1984 closely coinciding with Drs Barry Marshall and Robin Warren reporting gastric spiral bacteria with pathogenic role in ulcer disease. CDD was able to source gastric biopsies with Helicobacter pylori(HP) from numerous patients with ulcer disease creating the environment necessary for HP researc

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33

Weber, [geb Spalek] Evelyn. "Poststationäres Management Helicobacter pylori positiver Patienten im Raum Aschaffenburg." Doctoral thesis, 2018. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-156634.

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2009 wurde die deutsche S3-Leitlinie „Helicobacter pylori und gastroduodenale Ulkuskrankheit“ publiziert, in der klare Empfehlungen für die Diagnostik, die Indikationen für eine Eradikation, die Therapie und das Follow-Up beschrieben sind. Das Management der H. pylori Infektion im praktischen Alltag zeigt nach dieser Arbeit indessen ein anderes Bild. Ein Optimierungsbedarf für die Zukunft kann daraus abgeleitet werden. Diese Arbeit beschäftigt sich mit dem poststationären Management von Patienten mit einer H. pylori Infektion im Raum Aschaffenburg. Hierzu wurden 199 Patienten identifiziert, be

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Fritz, Nicola Elke [Verfasser]. "Helicobacter-pylori-Diagnostik und -Therapie in der Routineversorgung : eine Umfrage unter Ärzten und Patienten zur Evaluierung der nationalen Leitlinie / Nicola Elke Fritz." 2000. http://d-nb.info/962075582/34.

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Kroettinger, Annett [Verfasser]. "Effektivität der neuen 7-Tage-Tripel-Therapie mit Esomeprazol, Rifabutin und Amoxcillin [Amoxicillin] bei Infektionen mit Makrolid- und Imidazolresistenten Helicobacter-pylori-Stämmen / vorgelegt von Annett Kroettinger." 2002. http://d-nb.info/966094948/34.

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Kristen, Holger. "Einfluss einer probiotischen Mischkultur (BB2 und LA5) in einer Fruchtmatrix auf das gastrointestinale Wohlbefinden vor, während und nach einer antibiotischen Therapie und auf die Aktivität von Helicobacter pylori." 2006. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=015428536&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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