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Journal articles on the topic 'Pyranopyrazole'

Author: Grafiati

Published: 4 June 2025

Last updated: 15 July 2025

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1

Wagh, Shital* Dr. Prerana Jadhav Dr. Pradyumna Ige. "A Review on Pyranopyrazole as an Antibacterial Agent." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 1401–5. https://doi.org/10.5281/zenodo.12773245.

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<strong>Aim: </strong>In our review of various literary works, we have discovered numerous therapeutic properties associated with pyranopyrazole. Additionally, we have postulated that pyranopyrazole may exhibit antibacterial effects.  Pyranopyrazole derivatives are known to have biological significance, such as exhibiting anticancer, analgesic, and anti-inflammatory activities. They are also widely used in biodegradable agrochemicals and pharmaceutical constituents. Due to their applicability, the synthesis of pyranopyrazoles is currently receiving much attention. <strong>Data Source: </s

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2

Bais, Abhinav, Dinesh Chaple, Alpana Asnani, Pratyush Kumar, and Shrikant Mohurle. "Green synthesis of pyranopyrazole using microwave assisted techniques." GSC Biological and Pharmaceutical Sciences 10, no. 2 (2020): 111–19. https://doi.org/10.5281/zenodo.4280541.

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The process of drug discovery involves the identification of lead molecule, synthesis, characterization, screening, assay for therapeutic efficacy. The Pyrano[2,3-c] pyrazole are important roles in the field of pharmacological and medicinal chemistry. The pyranopyrazole are important class of hetrocyclic ring prepared by a diverse range of synthetic procedure. The water as a green solvent is most enviormentally friendly, safe and inexpensive choice to decrese pollution, toxicity and cost of reaction. The Microwave irridation to eliminate the requirement of heat, enhance the rate of reaction an

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3

Yusuf, Mohamad, and Saloni Thakur. "Multicomponent synthesis of new bis(pyranpyrazole) and their antimicrobial-antioxidant evaluations." Journal of the Serbian Chemical Society 84, no. 2 (2019): 119–28. http://dx.doi.org/10.2298/jsc171107074y.

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One-pot, three-component reactions were utilized to obtain a series of new symmetrical bis(pyranopyrazoles) built around six rigid linkers in good yields and in the short durations under normal conditions. The structures of the prepared compounds were confirmed using their IR, 1H-NMR, 13C-NMR and ESI-MS spectral parameters. The bis(pyranopyrazoles) 3b and 3f exhibited significant antimicrobial action against Klebsiella pneumoniae, Fusarium oxysporum and Penicillium glabrum at a minimum inhibitory concentration (MIC) value of 3.12 ?g mL-1, which is equivalent to the MIC of the standard drug. tr

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4

Bawa, Rashim, Nidhi Deswal, Swati Negi, Manu Dalela, Amit Kumar, and Rakesh Kumar. "Pyranopyrazole based Schiff base for rapid colorimetric detection of arginine in aqueous and real samples." RSC Advances 12, no. 19 (2022): 11942–52. http://dx.doi.org/10.1039/d2ra00091a.

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5

Pogaku, Bhadraiah, Janapati Srinu, Ramakanth Pagadala, Shyam Perugu, Radhika Mone, and Kamalaker Reddy Kamireddy. "SUSTAINABLE CONSTRUCTION OF PYRANOPYRAZOLES UTILIZING HClO4-SiO2 AS AN EFFICIENT SOLID CATALYST AND DOCKING STUDIES." RASAYAN Journal of Chemistry 17, no. 02 (2024): 531–37. http://dx.doi.org/10.31788/rjc.2024.1728826.

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This article introduces a highly proficient and environmentally friendly process for producing pyranopyrazole-5- carbonitriles with outstanding yields. This involves a multicomponent synthesis using commonly available aldehydes, malononitrile, ethyl acetoacetate, and phenylhydrazine, conducted in ethanol with perchloric acid supported on silica (HClO4-SiO2) as a solid catalyst. Utilizing HClO4-SiO2 as a reusable catalyst underscores the sustainability of this approach, offering a valuable green chemical strategy for pyranopyrazole synthesis. Characterization of the synthesized compounds was ac

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6

Bakthadoss, Manickam, and Manickam Surendar. "Cascade annulation reaction (CAR): highly diastereoselective synthesis of pyranopyrazole scaffolds." RSC Advances 10, no. 32 (2020): 19003–7. http://dx.doi.org/10.1039/d0ra03400b.

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7

Khazaei, Ardeshir, Mohammad Ali Zolfigol, Fatemeh Karimitabar, Iraj Nikokar, and Ahmad Reza Moosavi-Zare. "N,2-Dibromo-6-chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide: an efficient and homogeneous catalyst for one-pot synthesis of 4H-pyran, pyranopyrazole and pyrazolo[1,2-b]phthalazine derivatives under aqueous media." RSC Advances 5, no. 87 (2015): 71402–12. http://dx.doi.org/10.1039/c5ra10730j.

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8

D. Bhosle, Hanuman, Dattatraya N. Pansare, Ajit K. Dhas, and Rajita D. Ingle. "A FACILE SINGLE-POT SYNTHESIS OF PYRANOPYRAZOLES SCAFFOLD AS A GREEN APPROACH." RASAYAN Journal of Chemistry 17, no. 03 (2024): 855–60. http://dx.doi.org/10.31788/rjc.2024.1738818.

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A straightforward and environmentally friendly one-step method has been developed to synthesize pyranopyrazole with the aid of ultrasound in a water-based setting. This approach provides ease of operation and aligns with the tenets of green chemistry.

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9

Kumaravel, Kandhasamy, Balakrishnan Rajarathinam, and Gnanasambandam Vasuki. "Water-triggered union of multi-component reactions towards the synthesis of a 4H-chromene hybrid scaffold." RSC Advances 10, no. 49 (2020): 29109–13. http://dx.doi.org/10.1039/d0ra05105e.

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A union of multi-component reactions to construct pyrazole- and pyranopyrazole-adorned 4H-chromene from simple reactants in water at RT is reported. 2 distinct four-component reactions occur transiently to form 4 new heterocycles via 10 covalent bonds in a single step.

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10

Arbabi, Hamidreza Azari, Siavash Salek Soltani, Hasan Salehi, Shahla Rezazadeh, Afsaneh Zonouzi, and Mansoureh Toosibashi. "Convenient Synthesis of Heterocyclic Azo Dyes in the Class of Pyranopyrazoles and Chromenes." Journal of Chemical Research 42, no. 2 (2018): 68–72. http://dx.doi.org/10.3184/174751918x15177611816526.

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A series of novel azo group fused 2 H-chromenes and 4 H-chromenes were synthesised as well as pyranopyrazole derivatives via the Knoevenagel condensation reaction of C–H acid compounds with 5-(arylazo)salicylaldehydes by a nucleophilic addition to the carbonyl group followed cyclisation.

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11

Pore, D. M., P. B. Patil, D. S. Gaikwad, P. G. Hegade, J. D. Patil, and K. A. Undale. "Green access to novel spiro pyranopyrazole derivatives." Tetrahedron Letters 54, no. 44 (2013): 5876–78. http://dx.doi.org/10.1016/j.tetlet.2013.08.084.

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12

Sangle, S. L., D. R. Tope, A. V. Borhade, and S. S. Ghumare. "EFFICIENT SYNTHESIS OF PYRANOPYRAZOLE DERIVATIVES USING SILICA GRAFTED COPPER STANNATECATALYST." Journal of Advanced Scientific Research 13, no. 02 (2022): 38–43. http://dx.doi.org/10.55218/jasr.202213206.

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The CuSnO3:SiO2 catalyst was synthesized by hydrothermal method. The polycrystalline products were analyzed by using various physical investigative techniques including XRD, SEM, TEM and BET surface area. The present study deals with one-pot, four component reaction of aldehydes, malononitrile hydrazine hydrate and ethyl acetoacetate in the presence of catalytic amount of Silica grafted CuSnO3 in ethanol at 70°C to prepare series of pyranopyrazoles. This method gives high yield of pyranopyrazoles in short reaction time with economic availability of the catalyst and easy purification.

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13

Ghamari Kargar, Pouya, Ghodsieh Bagherzade, and Hossein Eshghi. "Retraction: Novel biocompatible core/shell Fe₃O₄@NFC@Co(ii) as a new catalyst in a multicomponent reaction: an efficient and sustainable methodology and novel reusable material for one-pot synthesis of 4H-pyran and pyranopyrazole in aqueous media." RSC Advances 14, no. 3 (2024): 1673. http://dx.doi.org/10.1039/d3ra90127k.

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Retraction of ‘Novel biocompatible core/shell Fe3O4@NFC@Co(ii) as a new catalyst in a multicomponent reaction: an efficient and sustainable methodology and novel reusable material for one-pot synthesis of 4H-pyran and pyranopyrazole in aqueous media’ by Pouya Ghamari Kargar et al., RSC Adv., 2020, 10, 37086–37097, https://doi.org/10.1039/D0RA04698A.

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14

Üçüncü, Muhammed, Ceren Cantürk, Erman Karakuş та ін. "A rare γ-pyranopyrazole skeleton: design, one-pot synthesis and computational study". Organic & Biomolecular Chemistry 14, № 31 (2016): 7490–94. http://dx.doi.org/10.1039/c6ob01099g.

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15

Bais Abhinav, Chaple Dinesh, Asnani Alpana, Kumar Pratyush, and Mohurle Shrikant. "Green synthesis of pyranopyrazole using microwave assisted techniques." GSC Biological and Pharmaceutical Sciences 10, no. 2 (2020): 111–19. http://dx.doi.org/10.30574/gscbps.2020.10.2.0026.

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16

Jelodar, Diana Fallah, Zoleikha Hajizadeh, and Ali Maleki. "Halloysite Nanotubes Modified by Chitosan as an Efficient and Eco-Friendly Heterogeneous Nanocatalyst for the Synthesis of Heterocyclic Compounds." Proceedings 41, no. 1 (2019): 59. http://dx.doi.org/10.3390/ecsoc-23-06615.

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In this study, halloysite nanotubes (HNTs) are modified by chitosan as a natural cationic amino polysaccharide. Halloysite nanotubes/chitosan (HNTs/Chit) were characterized by Fourier transform infrared (FT-IR) spectroscopy and energy dispersive X-ray (EDX) analysis. Also, its performance as a heterogeneous catalyst was investigated in the synthesis of pyranopyrazole derivatives. Being a reusable and easily recoverable catalyst, eco-friendliness, high efficiency, and mild reaction conditions are some advantages of the present work.

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17

Sangeeta, Har Lal Singh, Mamta Chahar, Saloni Sahal, and Sarita Khaturia. "GREENER SYNTHESIS OF PYRANOPYRAZOLE DERIVATIVES CATALYZED BY CaO NANOPARTICLES." Rasayan Journal of Chemistry 15, no. 01 (2022): 326–33. http://dx.doi.org/10.31788/rjc.2022.1516823.

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We report on the development of a novel green synthetic protocol for the series of pyrano-pyrazole derivatives (5an) in a one-pot multi-component method using CaO nanoparticles as the heterogeneous catalyst. The CaO nanoparticles were synthesized by a greener route using an economic and efficient alternative i.e. papaya leaf extract and exhibited excellent catalytic activity, and this plant-mediated synthesis of CaO nanoparticles is a very promising area of research. CaO nanoparticles can be efficiently used in the synthesis of pyrano-pyrazoles and this catalytic approach can deliver the appro

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18

Pore, D. M., P. B. Patil, D. S. Gaikwad, P. G. Hegade, J. D. Patil, and K. A. Undale. "ChemInform Abstract: Green Access to Novel Spiro Pyranopyrazole Derivatives." ChemInform 45, no. 10 (2014): no. http://dx.doi.org/10.1002/chin.201410106.

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19

Ganta, Ravi Kumar, Nagaraju Kerru, Suresh Maddila, and Sreekantha B. Jonnalagadda. "Advances in Pyranopyrazole Scaffolds’ Syntheses Using Sustainable Catalysts—A Review." Molecules 26, no. 11 (2021): 3270. http://dx.doi.org/10.3390/molecules26113270.

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Heterogeneous catalysis plays a crucial role in many chemical processes, including advanced organic preparations and the design and synthesis of new organic moieties. Efficient and sustainable catalysts are vital to ecological and fiscal viability. This is why green multicomponent reaction (MCR) approaches have gained prominence. Owing to a broad range of pharmacological applications, pyranopyrazole syntheses (through the one-pot strategy, employing sustainable heterogeneous catalysts) have received immense attention. This review aimed to emphasise recent developments in synthesising nitrogen-

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20

Guo, Rui-Yun, Zhi-Min An, Li-Ping Mo, et al. "Meglumine promoted one-pot, four-component synthesis of pyranopyrazole derivatives." Tetrahedron 69, no. 47 (2013): 9931–38. http://dx.doi.org/10.1016/j.tet.2013.09.082.

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21

Sharma, Ashok, Rajdeep Chowdhury, Subhra Dash, Badvel Pallavi, and Paritosh Shukla. "Fast Microwave Assisted Synthesis of Pyranopyrazole Derivatives as New Anticancer Agents." Current Microwave Chemistry 3, no. 1 (2015): 78–84. http://dx.doi.org/10.2174/2213335602666150116233238.

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22

Khandare, Priya M., Rajita D. Ingale, Aparna S. Taware, et al. "One Pot Synthesis and Biological Evaluation of Pyranopyrazole in Aqueous Medium." European Chemical Bulletin 6, no. 9 (2017): 410. http://dx.doi.org/10.17628/ecb.2017.6.410-414.

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23

Barqi, Mashael M., Assia Bashir, Muh ibnu sholeh, and Mohammed R. Eletmany. "Recent Developments in Pyranopyrazole Derivatives: Synthesis, Reactions, and Potential Pharmaceutical Applications." International Journal of Current Research in Science, Engineering & Technology 7, no. 3 (2024): 84–85. https://doi.org/10.30967/ijcrset/mohammed-r-eletmany/146.

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24

E. Ali, Tarik, Mohammed A. Assiri, Hafez M. El-Shaaer, et al. "Synthesis and Biological Activities of Some New Phosphorus Compounds Containing Pyranopyrazole Moiety." HETEROCYCLES 102, no. 6 (2021): 1119. http://dx.doi.org/10.3987/com-21-14448.

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25

Sonar, Jayant P., S. D. Pardeshi, S. A. Dokhe, et al. "ONE POT SYNTHESIS OF PYRANOPYRAZOLE USING SODIUM LACTATE AS AN EFFICIENT CATALYST." European Chemical Bulletin 8, no. 6 (2019): 207. http://dx.doi.org/10.17628/ecb.2019.8.207-211.

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26

Shukla, Paritosh, Ashok Sharma, Badvel Pallavi, Prabhat Nath Jha, and Rajnish Prakash Singh. "Novel Grinding Synthesis of Pyranopyrazole Analogues and Their Evaluation as Antimicrobial Agents." HETEROCYCLES 91, no. 8 (2015): 1615. http://dx.doi.org/10.3987/com-15-13222.

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27

Tangeti, Venkata Swamy, Kattaru Ramesh Babu, G. V. Siva Prasad, Tadikonda Ramu, and C. Venkata Rao. "Green chemical multicomponent approach for the synthesis of C3-pyranopyrazole-substituted coumarins." Journal of the Iranian Chemical Society 15, no. 4 (2018): 823–29. http://dx.doi.org/10.1007/s13738-017-1281-z.

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28

Guo, Rui-Yun, Zhi-Min An, Li-Ping Mo, et al. "ChemInform Abstract: Meglumine Promoted One-Pot, Four-Component Synthesis of Pyranopyrazole Derivatives." ChemInform 45, no. 15 (2014): no. http://dx.doi.org/10.1002/chin.201415159.

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29

A. Almehizia, Abdulrahman, Ahmad M. Naglah, Amer A. Zen, Tamer K. Khatab, and Ashraf S. Hassan. "TCS/ZnCl2 as a controlled reagent for the Michael addition and heterocyclic cyclization based on the phenyl pyrazolone scaffold with docking validation as a Covid-19 protease inhibitor." Bulletin of the Chemical Society of Ethiopia 38, no. 4 (2024): 1119–27. http://dx.doi.org/10.4314/bcse.v38i4.24.

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TCS/ZnCl2 is presented as a new catalyst for achieving the Michael addition adduct 5a-g by the reaction of phenyl pyrazolone 4 as the Michael donor and arylidene derivatives 3a-g as the Michael acceptor. The one-pot multi-component reaction of the same fragments' scaffolds as aldehydes 1a-g, malononitrile (2), and phenyl pyrazolone 4 with the same catalyst gives pyrano[2,3-c]pyrazole derivatives 6a-g as final products. The prepared compounds undergo docking validation as COVID-19 protease inhibitors and are compared with hydroxychloroquine as a reference drug. KEY WORDS: Pyranopyrazole, multi-

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30

Boukezzoula, Faiza, Taoues Boumoud, Boudjemaa Boumoud, and Abdelmadjid Debache. "An Efficient Organocatalyst for Environmentally benign Synthesis of Pyranopyrazole Derivatives in Aqueous Medium." Letters in Organic Chemistry 12, no. 10 (2015): 734–40. http://dx.doi.org/10.2174/1570178612666150924001127.

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31

Moosavi-Zare, Ahmad Reza, Mohammad Ali Zolfigol, Rasoul Salehi-Moratab, and Ehsan Noroozizadeh. "Catalytic application of 1-(carboxymethyl)pyridinium iodide on the synthesis of pyranopyrazole derivatives." Journal of Molecular Catalysis A: Chemical 415 (May 2016): 144–50. http://dx.doi.org/10.1016/j.molcata.2016.02.003.

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32

Nawwar, Galal A. M., Fathy M. Abdelrazek, and Randa H. Swellam. "Cinnamoylnitrile-, pyran-, and pyranopyrazole-derivatives containing the salicylanilide moiety with anticipated molluscicidal activity." Archiv der Pharmazie 324, no. 11 (1991): 875–77. http://dx.doi.org/10.1002/ardp.2503241110.

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33

Katariya, Dharmesh K., Amita K. Vyas, and Ranjan C. Khunt. "Exploring Microwave-Assisted Synthesis, Characterization, and Antimicrobial Proficiency of Pyranopyrazole-Based Quinoline Derivatives." Russian Journal of Organic Chemistry 60, S1 (2024): S59—S69. https://doi.org/10.1134/s1070428024130098.

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34

Sachdeva, Harshita, and Rekha Saroj. "ZnO Nanoparticles as an Efficient, Heterogeneous, Reusable, and Ecofriendly Catalyst for Four-Component One-Pot Green Synthesis of Pyranopyrazole Derivatives in Water." Scientific World Journal 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/680671.

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An extremely efficient catalytic protocol for the synthesis of a series of pyranopyrazole derivatives developed in a one-pot four-component approach in the presence of ZnO nanoparticles as heterogeneous catalyst using water as a green solvent is reported. Greenness of the process is well instituted as water is exploited both as reaction media and medium for synthesis of catalyst. The ZnO nanoparticles exhibited excellent catalytic activity, and the proposed methodology is capable of providing the desired products in good yield (85–90%) and short reaction time. After reaction course, ZnO nanopa

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35

Abdelattey, Mahmoud M., Zeinab R. Farag, Anouar El Hassane, Moustapha E. Moustapha, Abdelmoneim A. Makhlouf, and Ayman M. Yossef. "Synthesis, Antimicrobial Studies, and Molecular Docking Simulation of Novel Pyran, Pyrazole, and Pyranopyrazole Derivatives." Journal of Chemistry 2023 (December 7, 2023): 1–11. http://dx.doi.org/10.1155/2023/6623445.

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A group of compounds containing pyran, pyrazole, and pyranopyrazole were synthesized (2–4) using a facile and convenient protocol. The structure of the synthesized compounds was elucidated by spectroscopic and elemental analysis. In vitro antimicrobial evaluation was also performed for all synthesized derivatives against human pathogenic bacterial strains such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtilis using chloramphenicol as a reference. It was depicted that compounds 3d, 4b displayed a high degree of inhibition against Bacillus subtilis and Sta

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36

Oudghiri, Khaoula, Wafaa El Haila, Moha Taourirte, and Lahoucine Bahsis. "Exploring green catalysis with Zn(II)-chitosan-alginate beads for pyran and pyranopyrazole synthesis." International Journal of Biological Macromolecules 312 (June 2025): 144131. https://doi.org/10.1016/j.ijbiomac.2025.144131.

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37

Darabi, Mitra, Mohsen Nikoorazm, Bahman Tahmasbi, and Arash Ghorbani-Choghamarani. "Immobilization of Ni(ii) complex on the surface of mesoporous modified-KIT-6 as a new, reusable and highly efficient nanocatalyst for the synthesis of tetrazole and pyranopyrazole derivatives." RSC Advances 13, no. 18 (2023): 12572–88. http://dx.doi.org/10.1039/d2ra08269a.

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Anchoring of Ni(ii) complex onto the surface of mesoporous KIT-6 modified under mild reaction conditions as a highly efficient and reusable nanocatalyst for the synthesis of 5-substituted tetrazoles and pyranopyrazoles.

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38

Rahman, Noimur, Geetmani Singh Nongthombam, Jims World Star Rani, Ridaphun Nongrum, George Kupar Kharmawlong, and Rishanlang Nongkhlaw. "An Environment-Friendly Magnetic Organo-Nanomaterial as a Potent Catalyst in Synthesis of Pyranopyrazole Derivatives." Current Organocatalysis 5, no. 2 (2018): 150–61. http://dx.doi.org/10.2174/2213337205666180731095751.

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39

Wu, Mingshu, Qinqin Feng, Dehui Wan, and Jinya Ma. "CTACl as Catalyst for Four-Component, One-Pot Synthesis of Pyranopyrazole Derivatives in Aqueous Medium." Synthetic Communications 43, no. 12 (2013): 1721–26. http://dx.doi.org/10.1080/00397911.2012.666315.

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40

Kumar, Rakesh, Neha Yadav, Rodolfo Lavilla, et al. "Synthesis, pharmacological evaluation and molecular docking of pyranopyrazole-linked 1,4-dihydropyridines as potent positive inotropes." Molecular Diversity 21, no. 3 (2017): 533–46. http://dx.doi.org/10.1007/s11030-017-9738-7.

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41

Ismail, Magda M. F., Nagy M. Khalifa, Hoda H. Fahmy, Eman S. Nossier, and Mohamed M. Abdulla. "Design, Docking, and Synthesis of Some New Pyrazoline and Pyranopyrazole Derivatives as Anti-inflammatory Agents." Journal of Heterocyclic Chemistry 51, no. 2 (2013): 450–58. http://dx.doi.org/10.1002/jhet.1757.

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42

NAWWAR, G. A. M., F. M. ABDELRAZEK, and R. H. SWELLAM. "ChemInform Abstract: Cinnamoylnitrile, Pyran, and Pyranopyrazole Derivatives Containing the Salicylanilide Moiety with Anticipated Molluscicidal Activity." ChemInform 23, no. 22 (2010): no. http://dx.doi.org/10.1002/chin.199222164.

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43

Boukezzoula, Faiza, Taoues Boumoud, Boudjemaa Boumoud, and Abdelmadjid Debache. "ChemInform Abstract: An Efficient Organocatalyst for Environmentally Benign Synthesis of Pyranopyrazole Derivatives in Aqueous Medium." ChemInform 47, no. 11 (2016): no. http://dx.doi.org/10.1002/chin.201611071.

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44

Abdelatty, M. M., Zeinab R. Farag, Ayman M. Yossef, and Abdelmoneim A. Makhlouf. "Synthesis, characterization, in vitro antibacterial, and molecular modeling study of some pyrazole and pyranopyrazole derivatives." Fayoum Journal of Agricultural Research and Development 37, no. 3 (2023): 478–93. http://dx.doi.org/10.21608/fjard.2023.311856.

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45

Theresa, Letcy V., Savitha D. Pradeep, Deepa Sebastian, and K. Sreekumar. "Sustainable multicomponent one pot synthesis of pyranopyrazole derivatives in the presence of Lactic acid: Urea: NH4Cl." Current Research in Green and Sustainable Chemistry 4 (2021): 100194. http://dx.doi.org/10.1016/j.crgsc.2021.100194.

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46

Li, Zhipeng, Feiran Chen, Dongyang Wang, Xingtian Huang, and Yiqun Li. "Agarose Hydrogel Entrapped Trisodium Citrate Catalyzed Multicomponent Reactions for the Synthesis of Benzopyran and Pyranopyrazole Derivatives." Chinese Journal of Organic Chemistry 36, no. 4 (2016): 838. http://dx.doi.org/10.6023/cjoc201510010.

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47

Derabli, Chamseddine, Imen Boualia, Ahmed B. Abdelwahab, et al. "A cascade synthesis, in vitro cholinesterases inhibitory activity and docking studies of novel Tacrine-pyranopyrazole derivatives." Bioorganic & Medicinal Chemistry Letters 28, no. 14 (2018): 2481–84. http://dx.doi.org/10.1016/j.bmcl.2018.05.063.

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48

Moosavi-Zare, Ahmad Reza, Hamid Goudarziafshar, and Marzieh Alidadi. "Nano-Mn-[3-Nitrophenyl-Salicylaldimine-Methyl Pyranopyrazole] Cl2 as a New Schiff Base Complex and Catalyst." Polycyclic Aromatic Compounds 40, no. 3 (2019): 862–74. http://dx.doi.org/10.1080/10406638.2018.1504093.

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49

Moosavi-Zare, Ahmad Reza, Mohammad Ali Zolfigol, and Ahmad Mousavi-Tashar. "Synthesis of pyranopyrazole derivatives by in situ generation of trityl carbocation under mild and neutral media." Research on Chemical Intermediates 42, no. 10 (2016): 7305–12. http://dx.doi.org/10.1007/s11164-016-2537-4.

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Biswas, Swapan Kumar, and Debasis Das. "One-pot Synthesis of Pyrano[2,3-c]pyrazole Derivatives via Multicomponent Reactions (MCRs) and their Applications in Medicinal Chemistry." Mini-Reviews in Organic Chemistry 19, no. 5 (2022): 552–68. http://dx.doi.org/10.2174/1570193x19666211220141622.

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Abstract:

Background: Many pyrano[2,3-c]pyrazole derivatives display diverse biological activities and some of them are known as anticancer, analgesic, anticonvulsant, antimicrobial, antiinflammatory, and anti-malarial agents. In recent years, easy convergent, multicomponent reactions (MCRs) have been adopted to make highly functionalizedpyrano[2,3-c]pyrazole derivatives of biological interest. The synthesis of 1,4-dihydropyrano[2,3-c]pyrazole (1,4-DHPP, 2), 2,4- dihydropyrano[2,3-c]pyrazole (2,4-DHPP, 3), 4-hydroxypyrano[2,3-c]pyrazole (4-HPP, 4) derivatives, 1,4,4-substitied pyranopyrazole (SPP, 5) we

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