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Journal articles on the topic 'Pyranopyrimidines'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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1

Aremu, Oluwole S., Lebogang Katata-Seru, Olukayode O. Aremu, Constance R. Sewani-Rusike, and Neil Koorbanally. "Determination of radical scavenging activities of some pyrimidine derivatives." Tropical Journal of Pharmaceutical Research 19, no. 1 (2020): 45–49. http://dx.doi.org/10.4314/tjpr.v19i1.7.

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Purpose: To synthesize some pyrimidine derivatives and investigate their radical scavenging activities.
 Methods: A series of newly pyranopyrimidines derivatives and dithiopyridopyrimidinediones were synthesized by condensation of barbituric acid, malononitrile and different substituted benzaldehydes reacted with 1,4-Diazabicyclo[2.2.2] octane (DABCO) as a base. Compounds P1-7 (series 1), S1-11 (series 2) Scheme 1 and 6-amino-2-thiouracil with aromatic aldehydes in glacial acetic acid under reflux J1-13 (series 3) Scheme 2. 1H & 13C NMR, CHN, GC-MS and IR were used to characterize the
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2

Herrera, Antonio, Roberto Martínez-Alvarez, Pedro Ramiro, and John Almy. "An Easy Synthesis of Pyranopyrimidines." Monatshefte für Chemie - Chemical Monthly 137, no. 11 (2006): 1421–30. http://dx.doi.org/10.1007/s00706-006-0528-7.

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3

Bisenieks, Egils, Brigita Vigante, Ramona Petrovska, et al. "The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A." Pharmaceuticals 14, no. 10 (2021): 987. http://dx.doi.org/10.3390/ph14100987.

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The paradigm of ligand-receptor interactions postulated as “one compound—one target” has been evolving; a multi-target, pleiotropic approach is now considered to be realistic. Novel series of 1,4,5,6,7,8-hexahydro-5-oxoquinolines, pyranopyrimidines and S-alkyl derivatives of pyranopyrimidines have been synthesized in order to characterise their pleiotropic, multitarget activity on the FFA3/GPR41, FFA2/GPR43, and HCA2/GPR109A receptors. Hexahydroquinoline derivatives have been known to exhibit characteristic activity as FFA3/GPR41 ligands, but during this study we observed their impact on FFA2/
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4

El-Mekabaty, Ahmed, Hassan A. Etman, Ahmed Mosbah, and Ahmed A. Fadda. "Reactivity of Barbituric, Thiobarbituric Acids and Their Related Analogues: Synthesis of Substituted and Heterocycles-based Pyrimidines." Current Organic Chemistry 24, no. 14 (2020): 1610–42. http://dx.doi.org/10.2174/1385272824999200608134859.

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Barbituric, thiobarbituric acids and their related analogs are reactive synthons for the synthesis of drugs and biologically, and pharmaceutically active pyrimidines. The present review aimed to summarize the recent advances in the synthesis of different alkylsubstituted, fused cycles, spiro-, and binary heterocycles incorporated pyrimidine skeleton based on barbituric derivatives. In this sequence, the eco-friendly techniques under catalytic conditions were used for the diverse types of multicomponent reactions under different conditions for the synthesis of various types of heterocycles. Nan
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5

Pan, Y., A. Wu, Y. Zhu, S. Huang, J. Wan, and L. Yan. "Diastereoselective Routes to Thiazines, Oxazines and Pyranopyrimidines." Synfacts 2006, no. 10 (2006): 0999. http://dx.doi.org/10.1055/s-2006-949353.

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6

Kidwai, M., R. Venkataramanan, Rajesh K. Garg, and Kumar R. Bhushan. "Novel one pot synthesis of new pyranopyrimidines using microwaves." Journal of Chemical Research 2000, no. 12 (2000): 586–87. http://dx.doi.org/10.3184/030823400103166292.

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7

Kidwai, M., R. Venkataramanan, Rajesh K. Garg, and Kumar R. Bhushan. "ChemInform Abstract: Novel One-Pot Synthesis of New Pyranopyrimidines Using Microwaves." ChemInform 32, no. 20 (2001): no. http://dx.doi.org/10.1002/chin.200120121.

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8

Elnagdi, Mohamed Hilmy, Ramadan Maawad Abdel-Motaleb, Mona Mustafa, Mohamed Foad Zayed, and Eman Moustafa Kamel. "Studies on heterocyclic enamines: New syntheses of 4H-pyranes, pyranopyrazoles and pyranopyrimidines." Journal of Heterocyclic Chemistry 24, no. 6 (1987): 1677–81. http://dx.doi.org/10.1002/jhet.5570240635.

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9

Ahluwalia, V. K., R. Chandra, Rachna Aggarwal, and Shashi Bala Singh. "Base Catalysed Condensation of Acetone with Uracil Derivatives: One Step Synthesis of Pyranopyrimidines." Synthetic Communications 17, no. 12 (1987): 1435–40. http://dx.doi.org/10.1080/00397918708057769.

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10

Batran, Rasha Z., Dina H. Dawood, Samia A. El-Seginy, Timothy J. Maher, Kuljeet S. Gugnani, and Alejandro N. Rondon-Ortiz. "Coumarinyl pyranopyrimidines as new neuropeptide S receptor antagonists; design, synthesis, homology and molecular docking." Bioorganic Chemistry 75 (December 2017): 274–90. http://dx.doi.org/10.1016/j.bioorg.2017.09.017.

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11

Jiang, Xianxing, Yulong Sun, Jia Yao, et al. "Core Scaffold-Inspired Concise Synthesis of Chiral Spirooxindole-Pyranopyrimidines with Broad-Spectrum Anticancer Potency." Advanced Synthesis & Catalysis 354, no. 5 (2012): 917–25. http://dx.doi.org/10.1002/adsc.201100792.

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12

EL-HOSSINI, M. S., A. A. FADDA та M. N. KHODEIR. "ChemInform Abstract: Reactions of Heterocyclic β-Enaminoesters: A Novel Synthesis of Pyranopyrimidines and Related Compounds." ChemInform 22, № 12 (2010): no. http://dx.doi.org/10.1002/chin.199112215.

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13

Kamdar, Nimesh R., Dhaval D. Haveliwala, Prashant T. Mistry, and Saurabh K. Patel. "Design, synthesis and in vitro evaluation of antitubercular and antimicrobial activity of some novel pyranopyrimidines." European Journal of Medicinal Chemistry 45, no. 11 (2010): 5056–63. http://dx.doi.org/10.1016/j.ejmech.2010.08.014.

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14

Al-Omar, M. A., N. M. Khalifa, and A. E. Amr. "Synthesis and characterization of novel pyran and pyranopyrimidines linked 8-hydroxy-7-iodoquinoline-5-sulfonamide derivatives." Russian Journal of General Chemistry 87, no. 10 (2017): 2467–71. http://dx.doi.org/10.1134/s1070363217100309.

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15

Maleki, Ali, Abbas Ali Jafari, and Somayeh Yousefi. "Green cellulose-based nanocomposite catalyst: Design and facile performance in aqueous synthesis of pyranopyrimidines and pyrazolopyranopyrimidines." Carbohydrate Polymers 175 (November 2017): 409–16. http://dx.doi.org/10.1016/j.carbpol.2017.08.019.

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16

Jiang, Xianxing, Yulong Sun, Jia Yao, et al. "ChemInform Abstract: Core Scaffold-Inspired Concise Synthesis of Chiral Spirooxindole-Pyranopyrimidines with Broad-Spectrum Anticancer Potency." ChemInform 43, no. 33 (2012): no. http://dx.doi.org/10.1002/chin.201233179.

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17

Messaâd, Mehdi, Fakher Chabchoub, and Mansour Salem. "Synthese et Reactivité des Pyranopyrimidines Tosyles vis a vis du Chlorure de Thionyle: Obtention des 1,2,3,5-Thiatriazolopyrimidines." Phosphorus, Sulfur, and Silicon and the Related Elements 181, no. 11 (2006): 2529–34. http://dx.doi.org/10.1080/10426500600758324.

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18

Debbabi, Meriem, Vijaykumar D. Nimbarte, Samia Chekir, Sarra Chortani, Anis Romdhane, and Hichem Ben jannet. "Design and synthesis of novel potent anticoagulant and anti-tyrosinase pyranopyrimidines and pyranotriazolopyrimidines: Insights from molecular docking and SAR analysis." Bioorganic Chemistry 82 (February 2019): 129–38. http://dx.doi.org/10.1016/j.bioorg.2018.10.004.

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19

Yavari, Issa, Norollah Hazeri, Malek T. Maghsoodlou, and Nader Zabarjad-Shiraz. "Dynamic 1H NMR Study of Aryl-Nitrogen Single Bond and Carbon-Carbon Double Bond Rotational Energy Barriers in Two Highly Functionalized Pyranopyrimidines." Monatshefte fuer Chemie/Chemical Monthly 132, no. 6 (2001): 683–87. http://dx.doi.org/10.1007/s007060170082.

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20

FADDA, A. A., та H. M. HASSAN. "ChemInform Abstract: Reactions of Heterocyclic β-Enaminoester: Synthesis of Pyranopyrimidines and Pyrano(3′,2′:5,6)pyrimidino(2,3-c)(1,4) benzoxazine Ring System". ChemInform 22, № 8 (2010): no. http://dx.doi.org/10.1002/chin.199108214.

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21

Mohamed, Hany M., and Ashraf H. F. Abd El-Wahab. "Heteroaromatization with 4-Phenyldiazenyl-1-naphthol. Part IV: Synthesis of Some New Heterocyclic Compounds with Potential Biological Activity." Current Organic Synthesis 16, no. 6 (2019): 931–38. http://dx.doi.org/10.2174/1570179416666190719101727.

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Background: Synthetic azo compounds and their derivatives have been studied extensively due to their biological and pharmacological activities. Pyranopyridines, pyranopyrimidines and tetrazoles derivatives have emerged as a promising and attractive scaffold in the development of potent biological and pharmacological agents. Objectives: To design a series of new benzochromeno(pyridine/pyrimidine/tetrazole) derivatives and evaluate their antimicrobial activity against some bacterial strains (Gram-positive and Gram-negative) and some fungal strains. Materials and Methods: The (E)-7-(4-chloropheny
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22

Al-Sheikh, Ahmed, Masuma Begum, Bian Zhang, et al. "Molecular Diversity via Tetrasubstituted Alkenes Containing a Barbiturate Motif: Synthesis and Biological Activity." Molecules 25, no. 24 (2020): 5868. http://dx.doi.org/10.3390/molecules25245868.

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The synthesis of a molecularly diverse library of tetrasubstituted alkenes containing a barbiturate motif is described. Base-induced condensation of N1-substituted pyrimidine-2,4,6(1H,3H,5H)-triones with 5-(bis(methylthio)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione gave 3-substituted 5-(methylthio)-2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-triones (‘pyranopyrimidinones’), regioselectively. A sequence of reactions involving ring-opening of the pyran moiety, displacement of the methylthio group with an amine, re-formation of the pyran ring, and after its final cleavage with an amine, gave tetras
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23

Nagaraju, Pallava, Pedavenkatagari Narayana Reddy, Pannala Padmaja, and Vinod G. Ugale. "Synthesis, Antiproliferative Activity and Molecular Docking of New Thiazole/Benzothiazole Fused Pyranopyrimidine Derivatives." Letters in Organic Chemistry 17, no. 12 (2020): 951–58. http://dx.doi.org/10.2174/1570178617666200319114611.

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A new class of 4H,5H-benzo[4,5]thiazolo[3,2-a]pyrano[2,3-d]pyrimidin-5-one and 5H,6Hpyrano[ 2,3-d]thiazolo[3,2-a]pyrimidin-5-one derivatives were synthesized via the one-pot threecomponent reaction of 2-hydroxy-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-one and 7-hydroxy-5Hthiazolo[ 3,2-a]pyrimidin-5-one to various aromatic aldehydes and malononitrile. This domino transformation involves the formation of pyranopyrimidine ring by the formation of three C–C bonds and one C– O bond a single synthetic operation. As the products precipitate out of the reaction, simple filtration is enough to gather th
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24

Tahir, M. N., H. A. Shad, M. Haroon, M. Ashfaq, and R. J. Mancini. "A Pyranopyrimidine Derivative: Synthesis, Characterization, Hirshfeld Surface Analysis and Computational Investigation." Журнал структурной химии 64, no. 11 (2023): 118603. http://dx.doi.org/10.26902/jsc_id118603.

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A pyranopyrimidine derivative named as 10-amino-7-(2,4-diamino-6-oxidopyrimidin-1-ium-5-yl)-7H-benzo[7,8]chromeno[2,3-d]pyrimidin-9 -ium-8-olate dimethylformamide acetic acid hydrate (ADCP) is synthesized by the reaction of 2-hydroxy-1-naphthaldehyde and 2,6-diaminopyrimidin-4-ol in the presence of ethanol and dimethylformamide. The synthesized compound is characterized by single crystal X-ray diffraction technique. The molecule exists as a doubly zwitterion ion and the supramolecular assembly is stabilized by NH N, NH O and OH N bonding interactions. These intermolecular interactions are furt
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25

Tahir, M. N., H. A. Shad, M. Haroon, M. Ashfaq, and R. J. Mancini. "A Pyranopyrimidine Derivative: Synthesis, Characterization, Hirshfeld Surface Analysis and Computational Investigation." Journal of Structural Chemistry 64, no. 11 (2023): 2200–2212. http://dx.doi.org/10.1134/s0022476623110173.

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26

Mandrika, Ilona. "Search for HCA2, FFAR2 and FFAR3 receptor ligands in pyranopyrimidine and hexahydroquinoline ranges." Intrinsic Activity 5, Suppl. 2 (2017): A2.5. http://dx.doi.org/10.25006/ia.5.s2-a2.5.

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27

Tomas, A., Nguyen Huy Dung, B. Viossat, A. Esanu, and A. Rolland. "An original linkage between arabinose and a pyranopyrimidine derivative via a sulfur atom." Acta Crystallographica Section C Crystal Structure Communications 49, no. 3 (1993): 626–28. http://dx.doi.org/10.1107/s0108270192010448.

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28

M. Elsharif, Asma. "Synthesis of New Pyrimidinone Derivatives and Their Respective Biological Activity Assessment." Oriental Journal of Chemistry 35, no. 2 (2019): 658–67. http://dx.doi.org/10.13005/ojc/350221.

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Barbituric acid is converted into a pyrimidinone-incorporated pyrazolyl moiety (1), which is a key starting material. 1 can be converted into pyrimidine dione, isoxazole, pyrimidopyrimidine, and pyranopyrimidine by reacting with hydrazine hydrate and/or phenyl hydrazine, hydroxyl amine, urea, thiourea, guanidine, ethyl acetoacetate and ethyl cyanoacetate. Acylation of 1 gave an important key intermediate (7), which was condensed to form chalcone, which then underwent cycloaddition into cyclohexenes (8-13). Some newly synthesized compounds were screened as anti-diabetic agents and exhibited sig
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29

Shehab, Wesam S., Ahmed F. EL-Farargy, Abdou O. Abdelhamid, and Maged A. Aziz. "Synthesis and biological application of pyranopyrimidine derivatives catalyzed by efficient nanoparticles and their nucleoside analogues." Synthetic Communications 49, no. 24 (2019): 3560–72. http://dx.doi.org/10.1080/00397911.2019.1679538.

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30

Hafez, Hend N., Abdulrahman G. Alshammari, and Abdel-Rhman B. A. El-Gazzar. "Facile heterocyclic synthesis and antimicrobial activity of polysubstituted and condensed pyrazolopyranopyrimidine and pyrazolopyranotriazine derivatives." Acta Pharmaceutica 65, no. 4 (2015): 399–412. http://dx.doi.org/10.1515/acph-2015-0037.

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Abstract Reaction of 6-amino-3-methyl-4-(substituted phenyl)-1,4- dihydropyrano[2,3-c]pyrazole-5-carbonitrile (1) with triethylorthoformate followed by treatment with hydrazine hydrate, formic acid, acetic acid, phenylisocyanate, ammonium thiocyanate and formamide afforded the corresponding pyranopyrimidine derivatives 2-6. Cyclocondensation of 1 with cyclohexanone afforded pyrazolopyranoquinoline 7. One-pot process of diazotation and de-diazochlorination of 1 afforded pyrazolopyranotriazine derivative 8, which upon treatment with secondary amines afforded 9 and 10a- c. Condensation of 2 with
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31

Kanevskaya, I. V., A. S. Bondartsova, and O. V. Fedotova. "Biginelli Synthesis of Regioisomeric 5,6-Dihydro-4H-benzo[4,5]imidazo[1,2-a]pyranopyrimidin-4-ones." Russian Journal of Organic Chemistry 56, no. 10 (2020): 1753–57. http://dx.doi.org/10.1134/s1070428020100139.

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32

Mukherjee, Prasun, and Asish R. Das. "Spirocyclopropanes from Intramolecular Cyclopropanation of Pyranopyrazoles and Pyranopyrimidine-diones and Lewis Acid Mediated (3 + 2) Cycloadditions of Spirocyclopropylpyrazolones." Journal of Organic Chemistry 82, no. 5 (2017): 2794–802. http://dx.doi.org/10.1021/acs.joc.7b00089.

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33

Rana, Surjyakanta, Suresh Maddila, Kotaiah Yalagala, Suryanarayana Maddila, and Sreekantha B. Jonnalagadda. "Covalent Modification of Organo-Functionalized Graphene Oxide and its Scope as Catalyst for One-Pot Pyrazolo-Pyranopyrimidine Derivatives." ChemistryOpen 4, no. 6 (2015): 703–7. http://dx.doi.org/10.1002/open.201500121.

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34

Abd El-Wahab, Ashraf H. F. "Synthesis, Reactions and Evaluation of the Antimicrobial Activity of Some 4-(p-Halophenyl)-4H-naphthopyran, Pyranopyrimidine and Pyranotriazolopyrimidine Derivatives." Pharmaceuticals 5, no. 7 (2012): 745–57. http://dx.doi.org/10.3390/ph5070745.

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35

Ouf, N. H., Y. A. Selim, M. I. Sakran, and A. S. Badr El-din. "Synthesis of pyranochromene and pyranopyrimidine derivatives from substituted natural coumarin isolated from Ammi majus L. and their biological evaluation." Medicinal Chemistry Research 23, no. 3 (2013): 1180–88. http://dx.doi.org/10.1007/s00044-013-0724-z.

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36

Patil, Audumbar, Shivanand Gajare, Gajanan Rashinkar та Rajashri Salunkhe. "β-CD-SO3H: Synthesis, Characterization and Its Application for the Synthesis of Benzylpyrazolyl Naphthoquinone and Pyrazolo Pyranopyrimidine Derivatives in Water". Catalysis Letters 150, № 1 (2019): 127–37. http://dx.doi.org/10.1007/s10562-019-02928-y.

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37

FADDA, A. A., M. A. HANNA та M. M. GIRGES. "ChemInform Abstract: Reactions of Heterocyclic β-Enamino Esters. Synthesis of Pyranopyrimidine (V), Pyranopyridine (IX), and N-(Pyran-2-yl) azetidinone (XIII) Ring Systems." ChemInform 25, № 34 (2010): no. http://dx.doi.org/10.1002/chin.199434176.

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38

Moosavi-Zare, Ahmad Reza, Hamid Goudarziafshar, and Parva Fashi. "Nano-Co-[4-chlorophenyl-salicylaldimine-pyranopyrimidine dione]Cl2 as a new Schiff base complex and catalyst for the one-pot synthesis of some 4H-pyrimido[2,1-b]benzazoles." Research on Chemical Intermediates 46, no. 12 (2020): 5567–82. http://dx.doi.org/10.1007/s11164-020-04279-5.

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39

Elattar, Khaled M., Ayman Y. El-Khateeb, and Sahar E. Hamed. "Insights into the recent progress in the medicinal chemistry of pyranopyrimidine analogs." RSC Medicinal Chemistry, 2022. http://dx.doi.org/10.1039/d2md00076h.

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The current review highlights the importance of pyranopyrimidines as privileged biologically active molecules. It also discusses recent synthetic strategies for the synthesis of these compounds, the mechanism of action, and SARs.
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40

Bashar, Bashar S., Hawraa A. Kareem, Yaser Mohamed Hasan, et al. "Application of novel Fe3O4/Zn-metal organic framework magnetic nanostructures as an antimicrobial agent and magnetic nanocatalyst in the synthesis of heterocyclic compounds." Frontiers in Chemistry 10 (October 10, 2022). http://dx.doi.org/10.3389/fchem.2022.1014731.

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Using the microwave-assisted method, novel Fe3O4/Zn-metal organic framework magnetic nanostructures were synthesized. The crystallinity, thermal stability, adsorption/desorption isotherms, morphology/size distribution, and magnetic hysteresis of synthesized Fe3O4/Zn-metal organic framework magnetic nanostructures were characterized by XRD patterns, TGA curve, BET adsorption/desorption technique, SEM image, and VSM curve, respectively. After confirming the Fe3O4/Zn-metal organic framework magnetic nanostructures, its antimicrobial properties against Gram-positive bacterial, Gram-negative bacter
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41

Monem, Arezo, Davood Habibi, and Hadis Goudarzi. "An acid-based DES as a novel catalyst for the synthesis of pyranopyrimidines." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-45352-4.

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AbstractDeep eutectic solvents have countless advantages over normal solvents, and in addition to complying with the principles of green chemistry, depending on their nature, they can also act as catalysts. The use of deep eutectic solvents as acid catalysts has several advantages such as non-toxicity, a catalytic effect similar to or higher than the acid itself, and the possibility of recovery and reuse without significant loss of activity. In this project, A novel deep eutectic solvent (MTPPBr–PCAT–DES) was prepared from a one-to-one mole ratio of methyltriphenyl-phosphonium bromide (MTPPBr)
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42

Monem, Arezo, Davood Habibi, and Hadis Goudarzi. "A potential DES catalyst for the fast and green synthesis of benzochromenopyrimidines and pyranopyrimidines." Scientific Reports 14, no. 1 (2024). http://dx.doi.org/10.1038/s41598-024-69817-2.

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43

ELNAGDI, M. H., R. M. ABDEL-MOTALEB, M. MUSTAFA, M. F. ZAYED, and E. M. KAMEL. "ChemInform Abstract: Studies on Heterocyclic Enamines: New Syntheses of 4H-Pyrans, Pyranopyrazoles, and Pyranopyrimidines." ChemInform 19, no. 29 (1988). http://dx.doi.org/10.1002/chin.198829077.

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44

AHLUWALIA, V. K., R. CHANDRA, R. AGGARWAL, and S. B. SINGH. "ChemInform Abstract: Base-Catalyzed Condensation of Acetone with Uracil Derivatives: One- Step Synthesis of Pyranopyrimidines." ChemInform 19, no. 14 (1988). http://dx.doi.org/10.1002/chin.198814234.

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45

Moirangthem, Nimalini, and Warjeet S. Laitonjam. "A Facile Synthesis of 7-amino-1,3-diaryl-5- phenyl-2-thioxo-pyrano[2,3-d]pyrimidine- 4(5H)-ones." July 4, 2011. https://doi.org/10.5281/zenodo.8257.

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The reactions of arylidene derivatives such as ethylphenylmethylenemalononitrile 3a, ethylphenylmethylenecyanoacetate 3b and ethylphenylmethylenecyano-acetamide 3c with substituted thiobarbituric acids 2a-e in presence of NaOCH3 and MeOH afforded 7- amino-1,3-diaryl-5-phenyl-2-thioxo-pyrano[2,3-d]pyrimidin-4(5H)ones 4a-e and 5e by cyclocondensation.
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46

Harooni, Nasrin Saberi, Amir Hossein Ghasemi, and Hossein Naeimi. "Efficient and Mild Synthesis of Pyranopyrimidines Catalyzed by Decorated Multi-walled Carbon Nanotubes Bearing Cobalt, Nickel, and Copper Metals in Water." Journal of Cluster Science, November 5, 2022. http://dx.doi.org/10.1007/s10876-022-02374-8.

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47

Pooja, G. Sathya, and S. Banupriya. "Pyranopyrimidine: A Promising Scaffold with various Biological activities." Asian Journal of Pharmaceutical Research, March 8, 2024, 67–70. http://dx.doi.org/10.52711/2231-5691.2024.00010.

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Heterocyclic compounds are one of the most important molecules in the synthesis of pharmacologically active compounds. One of the most promising heterocycles among all is the pyranopyrimidine scaffold, that has been found in both natural and synthetic sources. It has been confirmed to possess a range of biological activity, including anti-HIV, anti-tubercular, anti-HBV, anti-dyslipidemic, anti-platelet, anti-inflammatory, antioxidant, and antibacterial properties. The objective of this review is to highlight significant pyranopyrimidine analogues with a range of biological activity.
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48

"Pyranopyrimidine–Triazole Hybrid Molecules." Synfacts 14, no. 10 (2018): 1026. http://dx.doi.org/10.1055/s-0037-1610973.

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49

Tehrani, Ramin Rezaee, Enayatollah Sheikhhosseini, Dadkhoda Ghazanfari, and Mohammadreza Akhgar. "Synthesis and Biological Examination of Novel Tetra Pyranopyrimidine Heterocycles Contained Lipophilic Spacers." Polycyclic Aromatic Compounds, April 15, 2022, 1–12. http://dx.doi.org/10.1080/10406638.2022.2059530.

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50

Nagaraju, Pallava, Pedavenkatagari Narayana Reddy, Pannala Padmaja, and Vinod G. Ugale. "Microwave assisted synthesis of thiazole/benzothiazole fused pyranopyrimidine derivatives and evaluation of their biological activity." Letters in Organic Chemistry 17 (May 17, 2020). http://dx.doi.org/10.2174/1570178617999200517130138.

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Abstract:
: A new class of phenylbenzo[4,5]thiazolo[3,2-a]pyrano[2,3-d]pyrimidin-5-one and pyrano[2,3-d]thiazolo[3,2-a]pyrimidine-5-one derivatives have been synthesized via one pot three-component reaction of 2-hydroxy-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-one and 7- hydroxy-5H-thiazolo[3,2-a]pyrimidin-5-one with various aromatic aldehydes and (E)-N-methyl-1-(methylthio)-2-nitroethenamine under microwave irradiation. This transformation involves formation of thiazole or benzothiazole fused pyranopyrimidinone ring by creation of two C–C bonds and one C–O bond in a single synthetic operation. This rapi
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