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Relevant bibliographies by topics / Pyrazine derivatives

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Journal articles

Academic literature on the topic 'Pyrazine derivatives'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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Journal articles on the topic "Pyrazine derivatives"

1

Hrynyshyn, Yevhenii, Hanna Musiichuk, Olena Komarovska-Porokhnyavets, et al. "Synthesis and Antimicrobial Activity of 4-Arylthio- and 4 Alkylthiofunctionalized Pyrazolo[1,5-a]pyrazines." Ukrainian Chemistry Journal 85, no. 1 (2019): 58–66. http://dx.doi.org/10.33609/0041-6045.85.1.2019.58-66.

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The reaction of pyrazolo[1,5-a]pyrazine-4(5H)ones with phosphorus tribromoxide in boiling benzene yielded 4-bromopyrazolo[1,5-a]pyrazines, and the thionation with phosphorus pentasulfide in pyridine at 90 °C led to pyrazolo[1,5-a]pyrazine-4(5H)thiones. The synthesized bromine derivatives are electrophilic, and thiones are nucleophilic substrates. Their subsequent structural modification in the first case was carried out by interaction with thiophenols, and in the second case was conducted with functional halogenoalkanes. It was shown that bromides react with substituted thiophenols in dimethyl

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2

Kučerová-Chlupáčová, Marta, Veronika Opletalová, Josef Jampílek, et al. "New Hydrophobicity Constants of Substituents in Pyrazine Rings Derived from RP-HPLC Study." Collection of Czechoslovak Chemical Communications 73, no. 1 (2008): 1–18. http://dx.doi.org/10.1135/cccc20080001.

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Pyrazine derivatives show a wide range of biological activities. 1-Pyrazin-2-ylethan-1-ones have served as food flavourants, and together with pyrazine-2-carbonitriles have been widely used as intermediates in the synthesis of various heterocyclic compounds. In our laboratory, substituted pyrazine-2-carbonitriles and 1-pyrazin-2-ylethan-1-ones have been used as intermediates for the preparation of potential antifungal and antimycobacterial drugs. Using established methods, a library of pyrazine derivatives was synthesized. Homolytic alkylation of commercially available pyrazine-2-carbonitrile

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3

Moravcová, Šárka, Vendula Fiedlerová, Jiří Tůma, Karel Musil, and Lenka Tůmová. "Effect of Selected Pyrazine Derivatives on the Production of Phenolics and Rutin in Urtica dioica and Fagopyrum esculentum." Natural Product Communications 11, no. 4 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100409.

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The effect of four pyrazine derivatives on the content of phenolic compounds in Urtica dioica L. and rutin in Fagopyrum esculentum Moench was studied. Pyrazine derivatives H1 and H2 were used on U. dioica, and derivatives S1 and S2 on F. esculentum, both separately and in combination with urea. The content of phenolic compounds in the stems of U. dioica after treatment with H2 at a concentration of 10−3 M significantly increased compared with the control and to a lower concentration of the same pyrazine derivative. In the case of S1 and S2 for F. esculentum, rutin content also increased in ste

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4

Ashraf-Khorassani, Mehdi, William M. Coleman, Michael F. Dube, and Larry T. Taylor. "Optimal Synthesis of Substituted and Branched Pyrazines via Reaction of Alpha Hydroxy Ketones with Selected Nitrogen Sources." Beiträge zur Tabakforschung International/Contributions to Tobacco Research 28, no. 6 (2019): 267–77. http://dx.doi.org/10.2478/cttr-2019-0006.

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SummaryEmployment of 1-hydroxy-acetone as a carbon source and NH4OH as a source of base and nitrogen, has enabled arrays of pyrazines to be synthesized. Reaction conditions such as temperature, time, carbon/nitrogen mole ratios and pH were optimized to maximize the quantity of pyrazines, thereby providing the synthesis of at least 19–20 structurally different pyrazines. Addition of amino acids, selected aldehydes, and hydrolyzed tobacco-derived F1 protein has positively impacted the array of pyrazines from both qualitative and quantitative aspects. Results further showed that by changing the c

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5

Jyothi, Boggavarapu, and Nannapaneni Madhavi. "Green Synthesis and Antimicrobial Activity of Some Novel N-Arylimidazo[1,2-a]pyrazine-2-Carboxamide Derivatives." Asian Journal of Chemistry 32, no. 1 (2019): 84–90. http://dx.doi.org/10.14233/ajchem.2020.22365.

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The article deals with the synthesis of some novel N-arylimidazo[1,2-a]pyrazine-2-carboxamides (7a-l) by condensation reaction of imidazo[1,2-a]pyrazine-2-carboxylic acid (5) with different aliphatic/aromatic amines (6a-l) by using 1-methylimidazole, Mukaiyama’s reagent and 2-chloro-1-methylpyridinium iodide under microwave irradiation conditions. A new series of compounds 7 have been prepared from 2-iodopyrazine (1). Compound 1 on purged with ammonia gas in the presence of Cu2O and K2CO3 furnishes pyrazin-2-amine (2), which is treated with ethyl 3-bromo-2-oxopropanoate (3) to produce ethyl im

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6

Diao, Li Xiao, Yue Zhi Cui, Xiang Jian Meng, and Xing Wu Liu. "The Two-Photon Excited Fluorescence of Pyrazine Derivatives." Advanced Materials Research 535-537 (June 2012): 1266–69. http://dx.doi.org/10.4028/www.scientific.net/amr.535-537.1266.

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A series of multi-branched pyrazine derivatives have been synthesized, of which, the two-branched one with para-branching pattern shows much enhanced two-photon absorption cross section (σ) than that with meta-branching pattern (1.8 times). The three-branched pyrazine derivative, in which the branches are at ortho- or para-position, show strong two-photon absorption properties (σ=753GM), while its s-triazine analogue TSTA, with all the branches in meta-position, exhibit too weak two-photon excited fluorescence to be detected. These results indicate great effects of branching pattern on two-pho

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7

Mager, H. I. X., and W. Berends. "Investigations on pyrazine derivatives." Recueil des Travaux Chimiques des Pays-Bas 76, no. 1 (2010): 28–34. http://dx.doi.org/10.1002/recl.19570760104.

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8

ONG, KOK TONG, ZHI-QIANG LIU, and MENG GUAN TAY. "Review on the Synthesis of Pyrazine and Its Derivatives." Borneo Journal of Resource Science and Technology 7, no. 2 (2017): 60–75. http://dx.doi.org/10.33736/bjrst.591.2017.

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Pyrazine is a kind of natural product which can be found in plants, animals, insects, marine organisms andmicroorganisms. The main function of pyrazine in living organisms is used as flavor of the raw foods. Pyrazine and its derivatives were also produced in industries mainly for fragrance, flavor and pharmaceutical applications. This review describes the historical development of pyrazine including the discovery and synthesis, to the recent synthetic approach of pyrazinium. In general, six synthetic approaches namely condensation reaction, ring closure, metal catalysis, green reaction, Mailla

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9

Das, Rina, and Dinesh Kumar Mehta. "Evaluation and Docking Study of Pyrazine Containing 1, 3, 4-Oxadiazoles Clubbed with Substituted Azetidin-2-one: A New Class of Potential Antimicrobial and Antitubercular." Drug Research 71, no. 01 (2020): 26–35. http://dx.doi.org/10.1055/a-1252-2378.

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Abstract Background Tuberculosis (TB) caused by Mycobacterium tuberculosis is one of the main killers of people all over the world. The major hurdles with existing therapy are the lengthy regimen and appearance of multi drug resistant (MDR) and extensively drug resistant (XDR) strains of M.tuberculosis. Aims The present work was aimed to synthesize and determine antitubercular and antimicrobial potential of some novel 3-chloro-4-aryl-1-[4-(5-pyrazin-2-yl[1,3,4]oxadiazole-2-ylmethoxy)-phenyl]-azetidin-2-one derivatives 7(a-h) from pyrazinoic acid as precursor, which is a well-established antitu

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10

Akune, Yoko, Risa Hirosawa, Atsushi Koseki, and Shinya Matsumoto. "Role of halogen substituents in a series of polymorphic 2,5-diamino-3,6-dicyanopyrazine derivatives with highly flexible groups." Zeitschrift für Kristallographie - Crystalline Materials 232, no. 5 (2017): 395–405. http://dx.doi.org/10.1515/zkri-2016-2007.

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AbstractThe crystal structures of the ortho-X-benzyl derivatives, where X=F, Cl, Br, I, and Me, of 2,5-bis(N,N-dibenzylamino)-3,6-dicyanopyrazine dyes (C34H24N6X4) were analysed to evaluate the effect of a systematic series of structures on the occurrence of polymorphism. Detailed crystal structure analysis indicated that the thermally stable forms of the polymorphic derivatives (Cl and Br derivatives) were close-packed, whereas those of the non-polymorphic derivatives (F and I derivatives) were stabilised by an intermolecular interaction involving the ortho-substituents. In the thermally meta

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