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Journal articles on the topic 'Pyrazines/pharmacology'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

OHTA, Akihiro, and Yutaka AOYAGI. "Reactions and Syntheses of Pyrazines." YAKUGAKU ZASSHI 117, no. 1 (1997): 1–17. http://dx.doi.org/10.1248/yakushi1947.117.1_1.

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2

Tong, Wenhua, Shuqin Wang, Haoran Xu, Zongwei Qiao, Liming Zhao, and Ying Yang. "Interaction and Binding Kinetics of Different Substituted Pyrazines with HSA: Based on Multispectral, Physiological Activity, and Molecular Dynamics Simulations." Journal of Food Biochemistry 2024 (March 25, 2024): 1–20. http://dx.doi.org/10.1155/2024/4373558.

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Pyrazine is a kind of compound containing pyrazine ring structure, which has attracted the attention of researchers because of its special aroma and healthcare function. It is currently used in spices, pharmaceuticals, food additives, and other industries. Human serum albumin (HSA) is a transport and storage protein in the human circulatory system. Previous research reported that pyrazine can interact with albumin, but the interaction between pyrazine and HSA has not been reported. Consequently, this study is based on the multispectral method and molecular dynamics (MD) simulation, exploring t

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3

Hou, Wen, Wei Dai, Hao Huang, et al. "Pharmacological activity and mechanism of pyrazines." European Journal of Medicinal Chemistry 258 (October 2023): 115544. http://dx.doi.org/10.1016/j.ejmech.2023.115544.

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4

Bohman, Bjorn, Ryan D. Phillips, Gavin Flematti, Rod Peakall, and Russell A. Barrow. "Sharing of Pyrazine Semiochemicals between Genera of Sexually Deceptive Orchids." Natural Product Communications 8, no. 6 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800605.

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It has recently been discovered that novel di-, tri- and tetra- substituted pyrazines are semiochemicals in Drakaea, an orchid genus that secures pollination by the sexual deception of male thynnine wasps. We examined if similar pyrazines were also present in the distantly related Caladenia barbarossa, a sexually deceptive orchid that is also pollinated by a thynnine wasp. Here we report for the first time the occurrence of two pyrazines, (3,5,6-trimethylpyrazin-2-yl)methyl 3-methylbutanoate (1) and 3-(3-methylbutyl)-2,5-dimethylpyrazine (2) in the orchid genus Caladenia. The former is known a

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5

Mitsuhashi, Keiryo, Toshinobu Suzuki, and Yasushi Nagae. "Synthesis of Condenced Polycyclic Pyrazines from Diaminomaleonitrule." HETEROCYCLES 24, no. 1 (1986): 231. http://dx.doi.org/10.3987/r-1986-01-0231.

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6

OHTA, Akihiro, Hiromitsu TAKAHASHI, Naoomi MIYATA, et al. "Anti-Platelet Aggregation Activity of Some Pyrazines." Biological & Pharmaceutical Bulletin 20, no. 10 (1997): 1076–81. http://dx.doi.org/10.1248/bpb.20.1076.

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7

Ohta, Akihiro, Tokuhiro Watanabe, Kazuhiro Hayashi, et al. "Alkylation and Arylation of Pyrazines by Organotin Compounds." HETEROCYCLES 29, no. 1 (1989): 123. http://dx.doi.org/10.3987/com-88-4728.

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8

Ohta, Akihiro, Ryoichi Itoh, Yasunobu Kaneko, Haruo Koike, and Kayo Yuasa. "Alkylation and Arylation of Pyrazines by Organoboron Compounds." HETEROCYCLES 29, no. 5 (1989): 939. http://dx.doi.org/10.3987/com-89-4904.

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9

Likhosherstov, A. M., V. P. Peresada, and A. P. Skoldinov. "New route to the synthesis of octahydropyrrolo[1,2-a]pyrazines." Pharmaceutical Chemistry Journal 27, no. 10 (1993): 716–18. http://dx.doi.org/10.1007/bf00780552.

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10

Quirion, Jean-Charles, Olivier Froelich, Françoise Cossart, Martine Bonin, and Henri-Philippe Husson. "Asymmetric Synthesis of Octahydro-2H-pyrido[1,2-a]pyrazines." HETEROCYCLES 51, no. 9 (1999): 2065. http://dx.doi.org/10.3987/com-99-8544.

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11

Vercek, Bojan, Tjasa Jug, Matjaz Polak, and Tomaz Trcek. "A Novel Approach to [1,2,3]Triazolo[1,5-a]pyrazines." HETEROCYCLES 56, no. 1-2 (2002): 353. http://dx.doi.org/10.3987/com-01-s(k)47.

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12

Arnoldi, Anna, Olga Baldi, and Albert Griffini. "Pulsed Positive/Negative Chemical Ionization Mass Spectrometry of Pyrazines." HETEROCYCLES 27, no. 12 (1988): 2875. http://dx.doi.org/10.3987/com-88-4741.

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13

Peresada, V. P., I. B. Tsorin, G. Yu Kirsanova, A. M. Likhosherstov, G. G. Chichkanov, and A. P. Skoldinov. "Azacycloalkanes. 31. Arylalkylpyrrolo[1,2-a]pyrazines and their effects on ischemized myocardium." Pharmaceutical Chemistry Journal 22, no. 10 (1988): 755–59. http://dx.doi.org/10.1007/bf00763268.

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14

Lund, Eric D. "Determination of 2-Methoxy-3-alkylpyrazines in Carrot Products by Gas Chromatography/Nitrogen–Phosphorus Detection." Journal of AOAC INTERNATIONAL 77, no. 2 (1994): 416–20. http://dx.doi.org/10.1093/jaoac/77.2.416.

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Abstract The 2-methoxy-3-alkylpyrazines in 6 types of carrot products were determined by a stripping–selective trapping procedure followed by purge-and-trap gas chromatographic analysis with an NP detector. The aroma threshold of one of the principal pyrazines, 2-methoxy-3-sec-butylpyrazine, in a carrot medium was 0.19 ng/g. The concentrations of this compound in whole-carrot products were 0.43 (fresh), 0.291 (canned, cooked), and 0.224 ng/g (frozen). A diced, cooked, and freeze-dried product contained 0.070 ng/g. All of these products contained only this pyrazine. In contrast, a shredded, bag

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15

Ohta, Akihiro, Masakatsu Ohta, Yohsiaki Igarashi, Kaemi Saeki, Kayo Yuasa, and Tomoko Mori. "Ethylation of Pyrazines Using Alkylmetals, Such as Triethylaluminum, Diethylzinc, and Triethylborane." HETEROCYCLES 26, no. 9 (1987): 2449. http://dx.doi.org/10.3987/r-1987-09-2449.

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16

V. S. Kong Thoo Lin, Paul, Robert Buchan, Martin Fraser, and Derek McHattie. "The Reaction of 8-Methylpyrrolo[1,2-a]pyrazines with Dimethyl Acetylenedicarboxylate." HETEROCYCLES 31, no. 8 (1990): 1459. http://dx.doi.org/10.3987/com-90-5386.

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17

Sliwa, Henri, Muriel Doise, and Dominique Blondeau. "Syntheses of 3,8-Dihydroxyimidazo[1,2-a]pyridines and [1,2-a]pyrazines." HETEROCYCLES 34, no. 11 (1992): 2065. http://dx.doi.org/10.3987/com-92-6013.

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18

Hasegawa, Minoru, Tohru Takabatake, and Tomoyuki Miyazawa. "Synthesis of Pyrido[2,3-b]pyrazines from Pyrido[2,3-c]furoxan." HETEROCYCLES 45, no. 1 (1997): 107. http://dx.doi.org/10.3987/com-96-7640.

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19

Saito, Ryota, Shinnosuke Machida, Saori Suzuki, and Akira Katoh. "Synthesis and Spectroscopic Properties of 2,5-Bis(benzoazol-2-yl)pyrazines." HETEROCYCLES 75, no. 3 (2008): 531. http://dx.doi.org/10.3987/com-07-11226.

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20

Fraser, Martin, Robert Buchan, and Paul V. S. Kong Thoo Lin. "Synthesis and Protonation of Dipyrrolo[1,2-a:2',1'-c]pyrazines." HETEROCYCLES 28, no. 2 (1989): 857. http://dx.doi.org/10.3987/com-88-s75.

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21

Kamal, Ahmed, G. Ramakrishna, P. Raju, et al. "Synthesis and anticancer activity of oxindole derived imidazo[1,5-a]pyrazines." European Journal of Medicinal Chemistry 46, no. 6 (2011): 2427–35. http://dx.doi.org/10.1016/j.ejmech.2011.03.027.

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22

Scheiber, Pál, Gábor Tóth, Mihály V. Pilipecz, Támas R. Varga, and Péter Nemes. "Chemistry of Nitroenamines. Part 2. Synthesis of Saturated Pyrrolo-pyrimidines and -pyrazines." HETEROCYCLES 83, no. 9 (2011): 2001. http://dx.doi.org/10.3987/com-11-12246.

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23

W. K. R. Mederski, Werner, Dieter Kux, Markus Knoth, and Markus J. Schwarzkopf-Hofmann. "Pyrido[3,4-b]pyrazines. A New Application of 2-Chloro-3,4-diaminopyridine." HETEROCYCLES 60, no. 4 (2003): 925. http://dx.doi.org/10.3987/com-02-9666.

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24

S. Ibrahim, Nadia, Mona H. Mohamed, Mona M. Hussien, and Mohamed H. Elnagdi. "Nitriles in Organic Synthesis. Synthesis of New Functionally Substituted Pyrazines and Pyrroles." HETEROCYCLES 27, no. 6 (1988): 1301. http://dx.doi.org/10.3987/com-87-4451.

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25

Z. Zard, Samir, Catherine Mougin, and Julien Sançon. "A Practical Route to Pyrazines and Quinoxalines, and an Unusual Synthesis of Benzimidazoles." HETEROCYCLES 74, no. 1 (2007): 211. http://dx.doi.org/10.3987/com-07-s(w)55.

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26

Takahashi, Masahiko, and Masahiko Hatazaki. "Synthesis of Pyrazolo[3,4-b]pyrazines from 5-Amino-4-nitrosopyrazoles and Dimethylphenacylsulfonium Bromides." HETEROCYCLES 41, no. 8 (1995): 1667. http://dx.doi.org/10.3987/com-95-7046.

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27

Wang, Li-Jiao, Zhi-Xing Cao, and Li Guo. "Design, Synthesis, and Preliminary Antitumor Activity Evaluation of Novel Alkaloid Derivatives." Natural Product Communications 15, no. 2 (2020): 1934578X2090353. http://dx.doi.org/10.1177/1934578x20903534.

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A novel alkaloid scaffold was designed through scaffold-hopping strategy based on the active pyrazines alkaloid isolated previously. A total of 25 derivatives were synthesized based on this scaffold and evaluated for their antitumor activities. Among all these tested compounds, 9f exhibited most excellent antitumor activities toward H460 cells, TMD-8 cells, and MV4-11 cells in vitro by 3-(4, 5-dimethyl-2-thiazolyl)-2,5-diphenyl-2 H-tetrazolium bromide assay with IC50 values of 29.8, 14.9, and 18.8 μM, respectively.

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28

MartÃnez, Ana, Carmen Ochoa, Juan RodrÃguez, et al. "Comparative Molecular Field Analysis (CoMFA) on [6] + [6] Fused Pyrazines with Nematocide Properties." Quantitative Structure-Activity Relationships 16, no. 5 (1997): 372–76. http://dx.doi.org/10.1002/qsar.19970160504.

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29

Erker, Thomas, and Karin Trinkl. "Preparation of Thieno[2,3-b]pyrazines as Bioisosteres for Quinoxaline Derivatives wiht Reverse Transcriptase Inhibition." HETEROCYCLES 57, no. 1 (2002): 97. http://dx.doi.org/10.3987/com-01-9371.

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30

Erker, Thomas, Karin Trinkl, and Franz Pertlik. "Synthesis of Thieno[2,3-b]pyrazines via an Acylation - Deacylation Process of 3,4-Dihydro Precursors." HETEROCYCLES 60, no. 2 (2003): 337. http://dx.doi.org/10.3987/com-02-9638.

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31

Peresada, V. P., O. S. Medvedev, A. M. Likhosherstov, and A. P. Skoldinov. "Azacycloalkanes XXX. Pyrrolo [1,2-a] pyrazines with variable degrees of pyrazine ring saturation and their hypotensive activity." Pharmaceutical Chemistry Journal 21, no. 9 (1987): 619–24. http://dx.doi.org/10.1007/bf01145551.

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32

Shindo, Kimio, Tetsuo Nozoe, and Sumio Ishikawa. "Synthesis and Rections of 2,3-Dihydrocyclohepta[b][1,4]thiazines and 2,3-Dihydro-1H-cyclohepta[b]pyrazines." HETEROCYCLES 28, no. 2 (1989): 733. http://dx.doi.org/10.3987/com-88-s139.

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33

Dawidowski, Maciej, Franciszek Herold, Andrzej Chodkowski, Jerzy Kleps, Paweł Szulczyk, and Marcin Wilczek. "Synthesis and anticonvulsant activity of novel 2,6-diketopiperazine derivatives. Part 1: Perhydropyrrole[1,2-a]pyrazines." European Journal of Medicinal Chemistry 46, no. 10 (2011): 4859–69. http://dx.doi.org/10.1016/j.ejmech.2011.07.027.

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34

González-Muñiz, Rosario, Mercedes Martín-Martínez, Ma Teresa García-López, and Rosario Herranz. "Studies on the Synthesis of Substituted 3,6-Dioxoperhydropyrrolo[1,2-a]pyrazines as Non-peptide Scaffolds for Peptidomimetics." HETEROCYCLES 45, no. 9 (1997): 1723. http://dx.doi.org/10.3987/com-97-7859.

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35

K. Mohapatra, Debendra, Pradip K. Maity, Ravindra V. Ghorpade та Mukund K. Gurjar. "Synthesis of New Chiral 5,6,7,8-Tetrahydrotetrazolo[1,5-a]pyrazines from α-Amino Acid Derivatives Following “Click“ Chemistry". HETEROCYCLES 77, № 2 (2009): 865. http://dx.doi.org/10.3987/com-08-s(f)121.

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36

Katoh, Akira, Shuhei Ueda, Junko Ohkanda, Mutsumi Hirota, Hiroshi Komine, and Keiryo Mitsuhashi. "Isolation of the Intermediates and Improved Synthesis of Pyrido[1',2':1,2]imidazo[4,5-b]pyrazines and -quinoxalines." HETEROCYCLES 34, no. 10 (1992): 1965. http://dx.doi.org/10.3987/com-92-6136.

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37

Zainullina, L., M. Sadowsky, G. Mokrov, et al. "P.0864 Novel pyrrolo[1,2-a]pyrazines TSPO ligands ameliorate SH-SY5Y cells survival upon lipopolysaccharide-induced cell damage." European Neuropsychopharmacology 53 (December 2021): S631—S632. http://dx.doi.org/10.1016/j.euroneuro.2021.10.721.

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38

Caballero, Julio, Szymon Zilocchi, William Tiznado, and Simona Collina. "Docking and quantitative structure–activity relationship studies for imidazo[1,2-a]pyrazines as inhibitors of checkpoint kinase-1." Medicinal Chemistry Research 21, no. 8 (2011): 1912–20. http://dx.doi.org/10.1007/s00044-011-9714-1.

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39

Liu, Yongjuan, Xia Lu, Tian Xue, Shiyuan Hu, and Huabei Zhang. "Receptor and ligand-based 3D-QSAR study on a series of pyrazines/pyrrolidylquinazolines as inhibitors of PDE10A enzyme." Medicinal Chemistry Research 23, no. 2 (2013): 775–89. http://dx.doi.org/10.1007/s00044-013-0619-z.

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40

Huang, Shi-linag, Hua-pei Jian, Xing-yuan Wang, Zhi-shu Huang, Shi-liang Huang, and Lian-quan Gu. "A Facile Synthesis of Novel Heteropolycyclic Pyrazines and Oxazoles Mechanistic Studies of 2,3-Dihydrobenzo[de]chromene-7,8-dione with Amines." HETEROCYCLES 75, no. 7 (2008): 1773. http://dx.doi.org/10.3987/com-08-11354.

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41

Kobayashi, Kazuhiro, and Teruhiko Suzuki. "A Convenient Two-Step Synthesis of 7-Aryl-6,7-dihydrothieno[2,3-b]pyrazines from Aryl(3-chloropyrazin-2-yl)methanones." HETEROCYCLES 87, no. 7 (2013): 1507. http://dx.doi.org/10.3987/com-13-12728.

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42

Blache, Yves, Alain Gueiffier, Olivier Chavignon, et al. "Reaction of 1-Ethoxalylmethylpyrido[2,3-b]pyrazinium Bromide with Ammonium Acetate: Synthesis of Imidazo[1',2':1,2]pyrido[5,6-b]pyrazines." HETEROCYCLES 38, no. 2 (1994): 283. http://dx.doi.org/10.3987/com-93-6521.

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43

Erker, Thomas, and Karin Trinkl. "Synthesis of 1,2,4-Oxadiazolylimidazo[1,5-a]thieno[2,3-e]pyrazines as Ligands for the g-Aminobutyric Acid A/Benzodiazepine Receptor Complex." HETEROCYCLES 55, no. 10 (2001): 1963. http://dx.doi.org/10.3987/com-01-9297.

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44

Wang, Fengxia, Qi Qian, Hanyu Ma, et al. "A Comparative Analysis of the Flavor, Aroma, and Compositions in Three Levels of Stir-Frying Cyperus rotundus Using E-Tongue, E-Nose, and HS-GC-MS." Journal of Food Biochemistry 2023 (July 13, 2023): 1–13. http://dx.doi.org/10.1155/2023/7499169.

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Cyperus rotundus (CR) is the dry rhizome of the Cyperaceae plant Cyperus, which is widely used in food processing, such as curry, pickling spices, and baking goods, as well as medicinally after stir-frying. The level of stir-frying (slightly stir-frying, stir-frying yellow, and stir-frying black) has a direct impact on the flavor, aroma, and pharmacological effects of the food. However, the distinctions between various levels of stir-frying have not been studied. The purpose of this study was to develop a method that combines electronic tongue, electronic nose, and HS-GC-MS to elucidate the fl

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45

Karabela, Sophia, Ioannis Psallidas, Taylor Sherrill та ін. "Opposing effects of bortezomib-induced nuclear factor-κB inhibition on chemical lung carcinogenesis." Carcinogenesis 33, № 4 (2012): 859–67. https://doi.org/10.1093/carcin/bgs024.

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Since recent evidence indicates a requirement for epithelial nuclear factor (NF)-κB signaling in lung tumorigenesis, we investigated the impact of the NF-κB inhibitor bortezomib on lung tumor promotion and growth. We used an experimental model in which wild-type mice or mice expressing an NF-κB reporter received intraperitoneal urethane (1 g/kg) followed by twice weekly bortezomib (1 mg/kg) during distinct periods of tumor initiation/progression. Mice were serially assessed for lung NF-κB activation, inflammation and carcinogenesis. Short-term proteasome inhibition with bortezomib did not impa

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46

Huang, Boshi, Xin Liang, Cuicui Li, et al. "Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: Design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines." European Journal of Medicinal Chemistry 93 (March 2015): 330–37. http://dx.doi.org/10.1016/j.ejmech.2015.02.022.

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47

Kosulin, Karin, Elena Lam, Albert Heim, Thomas Dobner, and Estefanía Rodríguez-Burgos. "Broad-spectrum antiviral activity of the deubiquitinase inhibitor HBX against human adenoviruses." Antivir Ther 23, no. 6 (2018): 475–783. https://doi.org/10.3851/IMP3230.

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Background: Human adenoviral (HAdV) infections are usually mild and self-limited, however, several types from species A, B, C, D and E, can cause severe illnesses that have raised public health concerns in the last years. Current available anti-viral therapies have limited efficacy and severe side effects, being an urgent need the finding of new targets for specific anti-adenoviral drug design. Our previous work has shown that the small molecule compound, HBX, inhibits HAdV-type 5 (species C) replication and oncogenic transformation through inhibition of the cellular pro-viral factor ubiquitin

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48

Hodoň, Jiří, Ivo Frydrych, Zdeňka Trhlíková, et al. "Triterpenoid pyrazines and pyridines – Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs." European Journal of Medicinal Chemistry, September 2022, 114777. http://dx.doi.org/10.1016/j.ejmech.2022.114777.

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49

"Synthesis of pyrazines and imidazoles using lemon juice (Citrus limon) as a recyclable catalyst." Indian Journal of Chemistry -Section B 59, no. 12 (2020). http://dx.doi.org/10.56042/ijcb.v59i12.30086.

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50

De, Surya K. "Novel Pyrazino[2,3-b] Pyrazines as mTOR Kinase Inhibitors for Treating Cancer and Other Diseases." Current Medicinal Chemistry 31 (July 26, 2023). http://dx.doi.org/10.2174/0929867331666230726112328.

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This paper describes the synthesis of some heteroaryl compounds and compositions comprising an effective amount of one or more such compounds and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway, comprising administering an adequate amount of a heteroaryl compound to a patient in need thereof. These compounds are mTOR/PI3K/Akt pathway inhibitors.

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