Log in

Relevant bibliographies by topics / Pyrazole derivatives

Contents

Journal articles
Dissertations / Theses
Books
Book chapters
Conference papers

Academic literature on the topic 'Pyrazole derivatives'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Pyrazole derivatives.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Pyrazole derivatives"

1

Abaszadeh, Mehdi, Hassan Sheibani, and Kazem Saidi. "The Condensation of (Chlorocarbonyl)phenyl Ketene with Bisnucleophiles. Synthesis of 4-Hydroxy-5-phenylpyro-[2,3-c]pyrazol-6-ones and Formation of Pyrazolo[1,2-a]pyrazole-triones by Hydrogen Exchange in Unstable Mesoionic Compounds." Australian Journal of Chemistry 63, no. 1 (2010): 92. http://dx.doi.org/10.1071/ch09344.

Full text

Abstract:

The addition of (chlorocarbonyl)phenyl ketene 2 to 5-alkylpyrazol-3(4H)-ones 1 led to the formation of 3-hydroxypyrazolo[1,2-a]pyrazole-dione/pyrazolo[1,2-a]pyrazole-trione derivatives 3. This is ascribed to hydrogen exchange in initially formed unstable, mesoionic pyrazolo[1,2-a]pyrazol-4-ium-5-olates. In contrast, condensation of the same ketene with 3-alkyl-1-phenyl-2-pyrazolin-5-ones 4 afforded 4-hydroxy-3-alkyl-1,5-diphenylpyrano[2,3-c]pyrazol-6-one derivatives 5. The latter reaction provides a new and rapid route to 4-hydroxy-2-pyrones fused to pyrazole rings, in good to excellent yields

APA, Harvard, Vancouver, ISO, and other styles

2

M., K. A. IBRAHIM, H. H. ELGHANDOUR A., S.M. ABDBL-SAYED G., and S.M. ABDEL FATTAH A. "Synthesis of Pyrazoles and Fused Pyrazoles. Novel Synthesis of Pyrano[2,3-c]pyrazole, Thieno[2,3-c]pyrazole and Pyrazolo[3,4-b ]pyridine Derivatives." Journal of Indian Chemical Society Vol. 74, Mar 1997 (1997): 206–8. https://doi.org/10.5281/zenodo.5885902.

Full text

Abstract:

Department of Chemistry, Faculty of Science, Cairo University, Giza, A. R. Egypt <em>Manuscript received 17 November 1994, revised 26 July 1995, accepted 28 September 1995</em> 3-Metbyl-1-thiocarbamoylpyrazoi-5-one (1) reacted with <em>p</em>-metbylpbenscyl bromide to give 3-metbyl-1(4-tbiazol-2-yl)pyrazol-5-one (2). Compounds 1 and 2 were reacted with reagents such as α-cyanocinnamo. benzaldehyde, elemental suJphurlmalononltrlle, benzenediazomum chloride, pyrazol-5-yl-diazonium chloride malononitriie, and ethyl acetoacetate to afford pyrano[2,3-<em>c</em>]pyrazoles (4, 6) Pyra

APA, Harvard, Vancouver, ISO, and other styles

3

Sophy, Mohamed Ahmed Elian, and Mohamed Ahmed Mahmoud Abdel Reheim. "Synthesis of Some New 1, 3, 4-Oxadiazole, Pyrazole, and Pyrimidine Bearing Thienopyrazole Moieties." Current Organic Synthesis 17, no. 8 (2020): 661–70. http://dx.doi.org/10.2174/1570179417999200730215318.

Full text

Abstract:

Aim and Objective: According to the literature survey, pyrazole is a unique template that is associated with several biological activities. This article highlighted the research work of many researchers reported in the literature for synthesis and different pharmacological activities of the pyrazole nucleus. In the present work, pyrazol- 3-one 1 was reacted with cyanoacetic acid hydrazide and elemental sulfur to afford the corresponding thieno[3,2-c]pyrazol-6-carbohydrazide 3 derivatives. The latter compound reacted with some electrophilic reagents such as DMF-DMA, triethylorthoformate, arylid

APA, Harvard, Vancouver, ISO, and other styles

4

Farooq, Saba, and Zainab Ngaini. "Chalcone Derived Pyrazole Synthesis via One-pot and Two-pot Strategies." Current Organic Chemistry 24, no. 13 (2020): 1491–506. http://dx.doi.org/10.2174/1385272824999200714101420.

Full text

Abstract:

Pyrazole is an imperative heterocyclic molecule in the synthetic and medicinal fields. Pyrazole is stable compound that is particularly used in pharmaceutical applications (i.e., anticancer, antifungal, antiviral, antimicrobial and antioxidant) and electronic industries. This review depicted the synthesis of pyrazoles derivatives by employing chalcone derivatives as a starting material via one and two-pot strategies. The one-pot strategy is an exclusive method for chalcone cyclization and oxidation, while two-pot strategy is reported through the preparation of chalcone derivatives, i.e., pyraz

APA, Harvard, Vancouver, ISO, and other styles

5

Alsayari, Abdulrhman, Yahya I. Asiri, Abdullatif Bin Muhsinah, and Mohd Zaheen Hassan. "Anticolon Cancer Properties of Pyrazole Derivatives Acting through Xanthine Oxidase Inhibition." Journal of Oncology 2021 (July 5, 2021): 1–5. http://dx.doi.org/10.1155/2021/5691982.

Full text

Abstract:

Background. Pyrazoles are an interesting class of compounds showing potent anticancer activities. Our previous studies have demonstrated the potent anticancer activity of pyrazole analogues. Therefore, we focused on developing anticancer agents through structure optimization of the pyrazolyl lead molecule. Methods. The pyrazole derivatives were prepared by the appropriate synthetic protocols. The antiproliferative activities were evaluated using a sulforhodamine B assay against three cancer cell lines. In vitro and in silico molecular docking studies employing xanthine oxidase were used to exp

APA, Harvard, Vancouver, ISO, and other styles

6

Lerner, Hans-Wolfram, Günter Margraf, Tonia Kretz, et al. "Redox Behaviour of Pyrazolyl-Substituted 1,4-Dihydroxyarenes: Formation of the Corresponding Semiquinones, Quinhydrones and Quinones." Zeitschrift für Naturforschung B 61, no. 3 (2006): 252–64. http://dx.doi.org/10.1515/znb-2006-0304.

Full text

Abstract:

Abstract Pyrazolyl-substituted 1,4-dihydroxybenzene and 1,4-dihydroxynaphthene derivatives have been synthesized by reaction of 1,4-benzoquinone and 1,4-naphthoquinone, respectively, with pyrazole. Cyclovoltammetric measurements have shown that 1,4-benzoquinone possesses the potential to oxidize 2-(pyrazol-1-yl)- and 2,5-bis(pyrazol-1-yl)-1,4-dihydroxybenzene. The 2,5-bis(pyrazol-1-yl)- 1,4-dihydroxybenzene reacts with air to give quantitatively black insoluble 2,5-bis(pyrazol-1-yl)-1,4- quinhydrone. Black crystals of 2,5-bis(pyrazol-1-yl)-1,4-quinhydrone suitable for X-ray diffraction were gr

APA, Harvard, Vancouver, ISO, and other styles

7

Alsayari, Abdulrhman, Abdullatif Bin Muhsinah, Yahya I. Asiri, et al. "Arylhydrazono/Aryldiazenyl Pyrazoles: Green One-Pot Solvent-Free Synthesis and Anticancer Evaluation." Letters in Organic Chemistry 17, no. 10 (2020): 772–78. http://dx.doi.org/10.2174/1570178617666200320104923.

Full text

Abstract:

The aim of this study was to synthesize and evaluate the biological activity of pyrazole derivatives, in particular, to perform a “greener” one-pot synthesis using a solvent-free method as an alternative strategy for synthesizing hydrazono/diazenyl-pyridine-pyrazole hybrid molecules with potential anticancer activity. Effective treatment for all types of cancers is still a long way in the future due to the severe adverse drug reactions and drug resistance associated with current drugs. Therefore, there is a pressing need to develop safer and more effective anticancer agents. In this context, s

APA, Harvard, Vancouver, ISO, and other styles

8

Farag, Awatef A., Mohamed F. El Shehry, Samir Y. Abbas, et al. "Synthesis of pyrazoles containing benzofuran and trifluoromethyl moieties as possible anti-inflammatory and analgesic agents." Zeitschrift für Naturforschung B 70, no. 7 (2015): 519–26. http://dx.doi.org/10.1515/znb-2015-0009.

Full text

Abstract:

AbstractSearching for new anti-inflammatory and analgesic agents, we have prepared a series of novel pyrazoles containing benzofuran and trifluoromethyl moieties. The pyrazole derivatives have been synthesized via two routes starting from 5-(3-(trifluoromethyl)phenyl azo) salicylaldehyde. The first route involved the synthesis of 2-acetylbenzofuran and then treatment with aldehydes to afford the corresponding chalcones. The cyclization of the latter chalcones with hydrazine hydrate led to the formation of new pyrazoline derivatives. The second route involved the synthesis of benzofuran-2-carbo

APA, Harvard, Vancouver, ISO, and other styles

9

Hrynyshyn, Yevhenii, Hanna Musiichuk, Olena Komarovska-Porokhnyavets, et al. "Synthesis and Antimicrobial Activity of 4-Arylthio- and 4 Alkylthiofunctionalized Pyrazolo[1,5-a]pyrazines." Ukrainian Chemistry Journal 85, no. 1 (2019): 58–66. http://dx.doi.org/10.33609/0041-6045.85.1.2019.58-66.

Full text

Abstract:

The reaction of pyrazolo[1,5-a]pyrazine-4(5H)ones with phosphorus tribromoxide in boiling benzene yielded 4-bromopyrazolo[1,5-a]pyrazines, and the thionation with phosphorus pentasulfide in pyridine at 90 °C led to pyrazolo[1,5-a]pyrazine-4(5H)thiones. The synthesized bromine derivatives are electrophilic, and thiones are nucleophilic substrates. Their subsequent structural modification in the first case was carried out by interaction with thiophenols, and in the second case was conducted with functional halogenoalkanes. It was shown that bromides react with substituted thiophenols in dimethyl

APA, Harvard, Vancouver, ISO, and other styles

10

M., K. A. IBRAHIM, H. H. ELGHANDOUR A., ABOU-HADEED K., and S. ABDELHAFIZ I. "Utility of Hydrazidoyl Chlorides : Synthesis of New Pyrazoles, Pyrazolo[ 3,4-d]pyridazines, Pyrazolo[4,5-b]pyridines and Pyrazolo[ 4,5-d]pyrimidine Derivatives." Journal of Indian Chemical Society Vol. 69, Jul 1992 (1992): 378–80. https://doi.org/10.5281/zenodo.6004337.

Full text

Abstract:

Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt Chemistry Department, Faculty of Science. Suez-Canal University, Ismalia, Egypt <em>Manuscript received 28 October 1991 revised 26 May 1992, accepted 3 June 1992</em> Hydrazidoyl chlorides (1) were reacted with a variety of active methylene compounds and arylidemnialononitriles .1 medium, to produce polyfunctionally substituted pyrazole derivatives (2-6 and 10). The pyrazoles (2, 3, 6 and 10) were converted into the corresponding pyrazolo[3, 4-<em>d</em>]pyridazine derivatives (7 - 9 and 14), respectively. The aminopyraiol

APA, Harvard, Vancouver, ISO, and other styles

More sources

Dissertations / Theses on the topic "Pyrazole derivatives"

1

Nakhai, Azadeh. "Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives." Stockholm, 2009. http://diss.kib.ki.se/2009/978-91-7409-687-3/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Yazici, Ceyda. "Synthesis Of 4-iodopyrazole Derivatives." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609750/index.pdf.

Full text

Abstract:

Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The electrophilic cyclization of the acetylenic hydrazones initiated by molecular iodine could provide new ways of synthesizing biologically active 4-iodopyrazole derivatives, which are important precursors for the synthesis of highly substituted pyrazole derivatives. For this reason, we investigated the synthesis of 4-iodopyrazole derivatives, such as 1-aryl- 5-alkyl/aryl-4-iodopyrazoles, star

APA, Harvard, Vancouver, ISO, and other styles

3

Gormen, Meral. "Synthesis Of Ferrocenyl Substituted Pyrazoles." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12606358/index.pdf.

Full text

Abstract:

Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The incorporation of the essential structural features of pyrazoles with a ferrocene moiety could provide new derivatives with unexpected and/or enhanced biological activities since several ferrocene derivatives have already been shown to be active against a number of tumors. For this reason, we investigated the synthesis of ferrocenyl-substituted pyrazoles, such as 1-alkyl/aryl-5-ferrocenylpyr

APA, Harvard, Vancouver, ISO, and other styles

4

Crotti, Simone. "Computer assisted synthesis and in-vitro cytotoxic evaluation of new pyrazole-fused isoquinolinoquinones derivatives as PI3K receptor antagonist with promising antitumoral activity." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/11206/.

Full text

Abstract:

The importance of pyrazole and isoquinoline-5,8-dione scaffolds in medical chemistry is underlined by the high number of drugs currently on trading that contains these active ingredients. Due to their cytotoxic capability, the interest of medicinal chemists in these heterocyclic rings has grown exponentially especially, for cancer therapy. In this project, the first synthesis of pyrazole-fused isoquinoline-5,8-diones has been developed. 1,3-Dipolar cycloaddition followed by oxidative aromatization, established by our research group, has been employed. Screening of reaction conditions and chara

APA, Harvard, Vancouver, ISO, and other styles

5

Pasin, Juliana Saibt Martins. "Atividade antipirética e antiinflamatória de derivados 5-trifluormetil-4,5-diidro-1H-1-carboxiamida pirazol em ratos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/28004.

Full text

Abstract:

A febre é um aumento regulado da temperatura corporal central, caracterizada por uma alteração no centro termorregulatório, a qual resulta da interação entre o sistema nervoso central e o imunológico. Enquanto a febre caracteriza lesão celular, infecção e inflamação, ela tem sido considerada o mais importante componente da resposta de fase aguda. Embora existam evidências de que a febre aumenta a defesa do hospedeiro, alguns estudos têm sugerido que o aumento da temperatura central a níveis febris pode ser prejudicial. Portanto, nas situações clínicas nas quais os riscos associados com a febre

APA, Harvard, Vancouver, ISO, and other styles

6

Chandanshive, Jay Zumbar <1983&gt. "Regiocontrolled Synthesis of Pyrazole Derivatives Through 1,3-Dipolar Cycloaddition Reaction And Synthesis of Helicene-Thiourea based and Polymer Supported Soos's Catalyst for Asymmetric Synthesis." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5826/1/Chandanshive_JAY_ZUMBAR_Thesis.pdf.

Full text

Abstract:

In first part we have developed a simple regiocontrolled protocol of 1,3-DC to get ring fused pyrazole derivatives. These pyrazole derivatives were synthesized using 1,3-DC between nitrile imine and various dipolarophiles such as alkynes, cyclic α,β-ketones, lactones, thiocatones and lactums. The reactions were found to be highly regiospecific. In second part we have discussed about helicene, its properties, synthesis and applications as asymmetric catalyst.Due to inherent chirality, herein we have made an attempt to synthesize the helicene-thiourea based catalyst for asymmetric catalysi

APA, Harvard, Vancouver, ISO, and other styles

7

Chandanshive, Jay Zumbar <1983&gt. "Regiocontrolled Synthesis of Pyrazole Derivatives Through 1,3-Dipolar Cycloaddition Reaction And Synthesis of Helicene-Thiourea based and Polymer Supported Soos's Catalyst for Asymmetric Synthesis." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5826/.

Full text

Abstract:

In first part we have developed a simple regiocontrolled protocol of 1,3-DC to get ring fused pyrazole derivatives. These pyrazole derivatives were synthesized using 1,3-DC between nitrile imine and various dipolarophiles such as alkynes, cyclic α,β-ketones, lactones, thiocatones and lactums. The reactions were found to be highly regiospecific. In second part we have discussed about helicene, its properties, synthesis and applications as asymmetric catalyst.Due to inherent chirality, herein we have made an attempt to synthesize the helicene-thiourea based catalyst for asymmetric catalysi

APA, Harvard, Vancouver, ISO, and other styles

8

Motson, Graham Robert. "Coordination chemistry of 3-(2'-pyridyl) pyrazole derivative ligands." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391153.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Mariappan, G. "Cardioprotective properties of pyrazotone derivatives in myocardial ischemic reperfusion injury." Thesis, University of North Bengal, 2011. http://hdl.handle.net/123456789/1501.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Dias, Sandra Isabel Godinho. "Synthesis and supramolecular phenomenon of novel pyrazine derivatives." Thesis, University of Kent, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429799.

Full text

APA, Harvard, Vancouver, ISO, and other styles

More sources

Books on the topic "Pyrazole derivatives"

1

Wiley, Richard H., and Paul F. Wiley. Pyrazolones, Pyrazolidones, and Derivatives. Wiley & Sons, Incorporated, John, 2009.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

2

Wiley, Richard H., and Paul F. Wiley. Pyrazolones, Pyrazolidones, and Derivatives. Wiley & Sons, Limited, John, 2007.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Pyrazole derivatives"

1

Niedenzu, Kurt, and Swiatoslaw Trofimenko. "Pyrazole derivatives of boron." In Topics in Current Chemistry. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/3-540-15811-1_1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Kabi, Arup K., Sattu Sravani, Raghuram Gujjarappa, et al. "Overview on Biological Activities of Pyrazole Derivatives." In Materials Horizons: From Nature to Nanomaterials. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-8399-2_7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Swarts, Steven G., Mei Zhang, Liangjie Yin, et al. "Antioxidant Properties of Select Radiation Mitigators Based on Semicarbazone and Pyrazole Derivatives of Curcumin." In Oxygen Transport to Tissue XXXII. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-7756-4_39.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Safi, Zaki S., Mohammed H. Rida, and Hassan M. Tamous. "Application of Density Functional Theory to Study the Anticorrosive Effects of Some Pyrazole Derivatives." In Corrosion Science. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003328513-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Angulwar, Jaman A. "Multicomponent Synthesis of 2-Substituted Derivatives of 6-Amino-5-Cyano-1,4-Dihydro-3-Methyl-1,4-Diphenylpyrano-[2,3-C]-Pyrazole Using Knoevenagel and Michael Addition." In Modern Green Chemistry and Heterocyclic Compounds. Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780367276942-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Fustero, Santos, Juan F. Sanz-Cervera, Antonio Simón-Fuentes, Raquel Román, Silvia Catalán, and Marcelo Murguía. "New Fluorinated Pyrazol and Uracil Derivatives: Synthesis and Biological Activity." In ACS Symposium Series. American Chemical Society, 2009. http://dx.doi.org/10.1021/bk-2009-1003.ch009.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Kang, Hyo Sim, Sun Wha Oh, and Young Soo Kang. "Comparison of Optical Properties of Pyrazoline Derivative Nanoparticles." In Solid State Phenomena. Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/3-908451-27-2.39.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Emandi, A., M. Calinescu, S. Ioachim, R. Georgescu, and I. Serban. "Synthesis and Characterization of the 2:1 Copper(II) Complexes With 4-Arylazo-Pyrazol-5-One Derivatives." In Multiphoton and Light Driven Multielectron Processes in Organics: New Phenomena, Materials and Applications. Springer Netherlands, 2000. http://dx.doi.org/10.1007/978-94-011-4056-0_36.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Caravatti, G., J. Brüggen, E. Buchdunger, et al. "Pyrrolo[2,3-d]pyrimidine and Pyrazolo[3,4-d]pyrimidine Derivatives as Selective Inhibitors of the EGF Receptor Tyrosine Kinase." In Anticancer Agents. American Chemical Society, 2001. http://dx.doi.org/10.1021/bk-2001-0796.ch014.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Pardasani, R. T., and P. Pardasani. "Magnetic properties of paradodecatungstate derivative of trinuclear copper(II) azido complex with 2-pyrazine carboxylic acid." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 8. Springer Berlin Heidelberg, 2023. http://dx.doi.org/10.1007/978-3-662-66460-5_484.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Pyrazole derivatives"

1

Gondek, E., J. Niziol, A. Danel, and J. Sanetra. "Photovoltaic effect based on pyrazole derivatives." In 2009 3rd ICTON Mediterranean Winter Conference (ICTON-MW 2009). IEEE, 2009. http://dx.doi.org/10.1109/ictonmw.2009.5385546.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Zveaghinteva, Marina, Natalia Sucman, and Fliur Macaev. "Preparation of pyrazole class derivatives by heterocyclization of 1,2,4-triazolylethanones." In Conferința științifică națională cu participare internațională "Integrare prin cercetare și inovare", dedicată Zilei Internaționale a Științei pentru Pace și Dezvoltare. Moldova State University, 2025. https://doi.org/10.59295/spd2024n.93.

Full text

Abstract:

In this work the peculiarities of the heterocyclization reaction of vinyltriazoles with the participation of hydrazine hydrate in ethanol and acetic acid are considered. Within the framework of this work it was found that the nature of the formed reaction products of the interaction of vinyltriazoles with hydrazine hydrate depends on the nature of the solvent. In boiling ethanol, 4,5-dihydro-1H-pyrazolinfunctionalized 1H-1,2,4-triazole is formed. Under acetic acid conditions, along with the formation of a pair of diastereomeric substances 4,5-dihydro-1H-pyrazoline series diastereomeric substan

APA, Harvard, Vancouver, ISO, and other styles

3

Krunić, Mihajlo J., Jelena Z. Penjišević, Slađana Kostić-Rajačić, Vladimir B. Šukalović, Deana B. Andrić, and Ivana I. Jevtić. "Pyrazole/tacrine derivatives as potential cholinesterase inhibitors." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.567k.

Full text

Abstract:

Two new tacrine/pyrazole conjugates were designed, synthesized, and pharmacologically evaluated for their inhibitory activity toward acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). A scalable and cost-efficient synthetic route was developed, and key reaction steps for the synthesis of compounds 4a,b were nucleophilic substitution of α-aroylketene dithioacetals with tacrine intermediates, followed by cyclocondensation of respective N,S-acetals with hydrazine hydrate. The preliminary pharmacological evaluation revealed high inhibitory activities of 4a,b toward AChE (180 and 259 nM

APA, Harvard, Vancouver, ISO, and other styles

4

Liu, Xiaobo, Shan Xu, and Yinhua Xiong. "Synthesis of 3-phenyl-1H-pyrazole Derivatives." In 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016). Atlantis Press, 2017. http://dx.doi.org/10.2991/emcm-16.2017.117.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Priyanka, S., S. Sivapriya, D. Sivakumar, M. Gopalakrishnan, M. Seenivasan, and H. Manikandan. "Synthesis and DFT calculation of novel pyrazole derivatives." In INTERNATIONAL CONFERENCE ON RECENT TRENDS IN APPLIED MATHEMATICAL SCIENCES (ICRTAMS-2020). AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0063016.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Adel, Mariam H., and Hiba H. Ibraheem. "Synthesis, molecular docking, and anti-tumor activity of pyrazole derivatives." In FIFTH INTERNATIONAL CONFERENCE ON APPLIED SCIENCES: ICAS2023. AIP Publishing, 2024. http://dx.doi.org/10.1063/5.0210692.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Patil, Sachin V., Manjusha B. Suryavanshi, Deepak R. Nagargoje, and Siddhant V. Kokate. "Synthesis and Antimicrobial Evaluation of Some New Pyrazole Derivatives Containing Thiazole Scaffolds." In ECSOC-25. MDPI, 2021. http://dx.doi.org/10.3390/ecsoc-25-11661.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Popusoi, Ana, Nicanor Barba, and Aurelian Gulea. "Synthesis of 1,3-Phenyl(Pyridyl)propenones with thiosemicarbazidic groups." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab03.

Full text

Abstract:

The bibliographic study of chalcones of the type 1,3-aryl(heteryl)propen-2-one with thiosemicarbazidic 4- and 1,4-disubstituted and thisemicarbazonic groups respectively gives us the information that they have a wide spectrum of biological activity, but methods of their synthesis are less described in the literature, and they became our object of study. 4,5-Dihydro-1-H-(pyrazol-3-yl)phenylhydrazinecarbothioamides 3a and 3b were obtained according to the following scheme:Reagents and reaction conditions: i, ii) 2-Py, 25oC – 24h, 90-95oC – 3h, 77-82%; iii) DMF, CH3COOH, 70-80oC, 2-3h, 60-63%. Fi

APA, Harvard, Vancouver, ISO, and other styles

9

Ali, Tarik, Somaia Abdel-Karim, Kamilia El-Mahdy, and Salah Abdel-Aziz. "Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit." In The 14th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2010. http://dx.doi.org/10.3390/ecsoc-14-00374.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Adel, Mariam H., and Hiba H. Ibraheem. "Novel pyrazole derivatives from N-substituted pyridinyl chalcones as anticancer agents: Synthesis and biological evaluation studies." In 4TH INTERNATIONAL CONFERENCE ON INNOVATION IN IOT, ROBOTICS AND AUTOMATION (IIRA 4.0). AIP Publishing, 2025. https://doi.org/10.1063/5.0254372.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!