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Journal articles on the topic 'Pyrazolics derivate'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Abeed, Ahmed A. O., Talaat I. El-Emary, and Mohamed S. K. Youssef. "A Facile Synthesis and Reactions of Some Novel Pyrazole-based Heterocycles." Current Organic Synthesis 16, no. 3 (2019): 405–12. http://dx.doi.org/10.2174/1570179416666181210160908.

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<p>Aim and Objective: This work presents the synthetic capability and the exploitation of 1,3-diphenyl- 1H-pyrazole-4-carboxladehyde 1 and 5-diphenyl pyrazolyl-2-pyrazoline analogue 8 to serve as excellent precursors for the synthesis of substituted indol-2,3-dione, trizolo[3,4-a]benzazoles, thiazolo[2,3- a]benzimidazole-3-one, substituted 2-pyrazoline and pyrazole-substituted-pyrazolines using various reagents. </P><P> Materials and Methods: Using chemicals from Aldrich, Fluka, or Merck, and pure solvents, we apply the synthetic procedures for the synthesis of novel heterocy

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2

Journal, Baghdad Science. "Synthesis of New Heterocyclic Derivatives from 4-(3, 5-Dimethyl-1-phenyl-1H-pyrazol-4-ylazo)- benzoic acid." Baghdad Science Journal 7, no. 1 (2010): 727–36. http://dx.doi.org/10.21123/bsj.7.1.727-736.

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In this work pyrazolin derivatives were prepared from the diazonium chloride salt of 4-aminobenzoic acid. Azo compounds were prepared from the reaction of an ethanolic solution of sodium acetate and calculated amount of active methylene compound namely, acetyl acetone to obtain the corresponding hydrazono derivative (1). Cyclocondensation reaction of compounds (1) with hydrazine hydrate and phenyl hydrazine in boiling ethanol affording the corresponding pyrazoline-5-one derivatives of 4-aminobenzoic acid (2,3). Then compound (3) was reacted with thionyl chloride to give the corresponding acid

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3

El-Ossaily, Y. A. B., R. M. Zaki, and S. A. Metwally. "Investigation and Synthesis of Some Novel Spiro Heterocycles Related to Indoline Moiety." Journal of Scientific Research 6, no. 2 (2014): 293–307. http://dx.doi.org/10.3329/jsr.v6i2.17590.

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Reactions of indole-2,3-dione 1 with 2-mercaptobenzimidazole, o-phenylenediamine, 2-aminophenol, 2-aminobenzothiazole, 2-aminobenzimidazole and 3-methyl-1-phenyl-2-pyrazolin-5-one were carried out to give compounds spiroindolethiazetobenzimidazole 2, spirobenzimidazole(oxazole)indoline 3a,b, benzothiazol(imidazol) iminoindolinone 4a,b and methyloxoindolylidenepyrazolone 5 respectively. Compound 5 was reacted with 2-aminophenol as well as o-phenylenediamine to give new spirooxazepine and diazepine derivatives 6a,b respectively. Reaction of 5 with nitrogen nucleophiles as well as carbon nucleoph

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4

Sultan, Mohammed Ibrahim, Ahmed M. Abdula, Rana I. Faeq, and Mahdi F. Radi. "New Pyrazoline Derivatives Containing Imine Moiety: Synthesis, Characterization and Antimicrobial Study." Al-Mustansiriyah Journal of Science 32, no. 3 (2021): 8. http://dx.doi.org/10.23851/mjs.v32i3.955.

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A new series of pyrazoline derivatives (3-10) have been synthesized and characterized on the basis of FT-IR, 1H-NMR, and Mass techniques. 1-(4-Aminophenyl)-3-(pyridin-4-yl)prop-2-en-1-one (1) as a starting material was prepared by the reaction of 4-aminoacetophenone and 4-pyridinecarboxaldehyde in ethanol, using sodium hydroxide as a catalyst. Pyrazoline derivatives 2 was obtained via the cyclization reaction of compound 1 by the action of hydrazine hydrate 80% in ethanol. The target derivatives (3-8) were obtained by the reaction of pyrazoline derivative (2) with the corresponding aldehyde in

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5

Kang, Hyo Sim, Sun Wha Oh, and Young Soo Kang. "Comparison of Optical Properties of Pyrazoline Derivative Nanoparticles." Solid State Phenomena 119 (January 2007): 39–42. http://dx.doi.org/10.4028/www.scientific.net/ssp.119.39.

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We prepared various pyrazoline derivatives which possess dimethylamino-, ethoxy-, isopropyl-phenyl ring at the 5-position of pyrazoline. The nanoparticles of pyrazoline derivative ranging from tens to hundreds of nanometers by the reprecipitation method have been successfully prepared and their optical size-dependent properties have been investigated with UV-vis, fluorescence spectroscopy, DLS (Dynamic Light Scattering) and SEM. The size-dependent optical properties of pyrazoline organic nanoparticles have been observed in the order of dimethylamino- > ethoxy- > isopropyl- in electro-don

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6

Santoso, Broto. "3D-MOLECULAR SCREENING OF DIKETOPIPERAZINE DERIVATES ON Staphylococcus aureus DEHYDROSQUALENE SYNTHASE USING VINA." Pharmacon: Jurnal Farmasi Indonesia 13, no. 1 (2015): 24–29. http://dx.doi.org/10.23917/pharmacon.v13i1.23.

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Dehydrosqualene synthase enzyme has been used as protein target model for exploring docking simulation of pyrazoline analogues. One of diketopiperazine derivates that have similar structure to pyrazoline has antibacterial activity against Staphylococcus aureus (S. aureus). Vina is AutoDock- improved program that capable for molecular screening based on free-energy and binding conformation prediction between ligand and protein target. The aim of these studies is to screen diketopiperazine derivates on dehydrosqualene synthase of S. aureus using Vina. Diketopiperazine derivates, curcumin analogu

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7

Guo, Shengmei, Yuyang Zhang, Jianyan Huang, Lin Kong, and Jiaxiang Yang. "High dual-state blue emission of a functionalized pyrazoline derivative for picric acid detection." CrystEngComm 23, no. 1 (2021): 221–26. http://dx.doi.org/10.1039/d0ce01195a.

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8

Varghese, Beena, Saleh N. Al-Busafi, Fakhr Eldin O. Suliman, and Salma Al-Kindy. "Study on the Reactivity of Amino Acid Chemosensor, NPFNP, with Ethanol: Structural Elucidation through Single Crystal XRD and DFT Calculations." Sultan Qaboos University Journal for Science [SQUJS] 22, no. 1 (2017): 16. http://dx.doi.org/10.24200/squjs.vol22iss1pp16-28.

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A novel ethoxy derivative of an amino acid chemosensor, 3-naphthyl-1-phenyl-5-(2ʹ-fluoro-5ʹ-nitrophenyl)-2-pyrazoline (NPFNP), has been synthesized and characterized by different spectroscopic methods. A single crystal of the ethoxy derivative, 3-naphthyl-1-phenyl-5-(2ʹ-ethoxy-5ʹ-nitrophenyl)-2-pyrazoline NPENP, has been obtained and characterized. The structure holds interest as it carries biologically active pyrazoline as a central ring attaching to electron donating and withdrawing substituents. The major motivation for this work was to gain detailed insight into the structural parameters o

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9

Duong Khanh, Linh, My Hanh Trinh Thi, Thuy Quynh Bui Thi, Trung Vu Quoc, Vuong Nguyen Thien, and Luc Van Meervelt. "Synthesis, crystal structure and Hirshfeld surface analysis of 4-[3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-5-yl]-2-methoxyphenol monohydrate." Acta Crystallographica Section E Crystallographic Communications 75, no. 11 (2019): 1590–94. http://dx.doi.org/10.1107/s2056989019013379.

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In the title pyrazoline derivative, C16H16N2O3·H2O, the pyrazoline ring has an envelope conformation with the substituted sp 2 C atom on the flap. The pyrazoline ring makes angles of 86.73 (12) and 13.44 (12)° with the trisubstituted and disubstituted benzene rings, respectively. In the crystal structure, the molecules are connected into chains running in the b-axis direction by O—H...N hydrogen bonding. Parallel chains interact through N—H...O hydrogen bonds and π–π stacking of the trisubstituted phenyl rings. The major contribution to the surface contacts are H...H contacts (44.3%) as conclu

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10

Szukalski, Adam, Maria Moffa, Andrea Camposeo, Dario Pisignano, and Jaroslaw Mysliwiec. "All-optical switching in dye-doped DNA nanofibers." Journal of Materials Chemistry C 7, no. 1 (2019): 170–76. http://dx.doi.org/10.1039/c8tc04677h.

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11

Nath, Chandrani, Vishnu Nayak Badavath, Abhishek Thakur, et al. "Curcumin-based pyrazoline analogues as selective inhibitors of human monoamine oxidase A." MedChemComm 9, no. 7 (2018): 1164–71. http://dx.doi.org/10.1039/c8md00196k.

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12

Mistry, Rakesh N., and K. R. Desai. "Studies on Synthesis of Some Novel Heterocyclic Chalcone, Pyrazoline, Pyrimidine - 2 - One, Pyrimidine - 2 - Thione,para-Acetanilide Sulphonyl and Benzoyl Derivatives and their Antimicrobial Activity." E-Journal of Chemistry 2, no. 1 (2005): 30–41. http://dx.doi.org/10.1155/2005/953107.

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1, 2 - Dichloro benzene on chlorosulphonation by chlorosulphonic acid gives 1, 2 - [dichloro] - benzene sulphonyl chloride which on condensation withp–amino acetophenone gives 1-[acetyl] - 1’ , 2’ - [dichloro] - dibenz sulphonamide derivative. This derivative undergo condensation with 2,4- dichloro benzaldehyde gives 1- [3” - (sub. phenyl) - 2” - propene - 1” - one] - 1’ , 2’ - [dichloro] - dibenz sulphonamide derivative which on reaction with 99% hydrazine hydrate and glacial acetic acid gives 1-[acetyl]-3- [1’ , 2’ - (dichloro) - dibenz sulphonamide] -5 - [2” , 4” - dichloro phenyl] - 2 - py

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13

Yu, Xinzhang, Yu-Zhu Shang, Yu-Fei Cheng, Jun Tian, Yulan Niu та Wen-Chao Gao. "Synthesis of 4-chalcogenyl pyrazoles via electrophilic chalcogenation/cyclization of α,β-alkynic hydrazones". Organic & Biomolecular Chemistry 18, № 9 (2020): 1806–11. http://dx.doi.org/10.1039/d0ob00050g.

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14

El-Alali, Abdullah, and Ahmed S. Al-Kamali. "Reactions of 1,3-dipolar aldazines and ketazines with the dipolarophile dimethyl acetylenedicarboxylate." Canadian Journal of Chemistry 80, no. 10 (2002): 1293–301. http://dx.doi.org/10.1139/v02-169.

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The prepared aldazines (aldehyde azines) and ketazines (ketone azines) were allowed to react with 2 mol of the acetylene derivative. The first products formed were pentalene azine derivatives, which in some cases underwent skeletal rearrangment into acyclic tetraene azines. The latter underwent, in the case of some aldazine products, further skeletal rearrangment into N-allyl pyrazoles. The occurence of these rearrangments is dependant on the nature of the aldehydes or ketones used.Key words: dimethyl acetylenedicarboxylate (DMAD), aldazines, ketazines, N-allyl pyrazoles.

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15

Kreutzberger, Alfred, and Karl Kolter. "Entzündungshemmende Wirkstoffe, 10. Mitt.1). 1-(4-Chlorphenyl)-2-pyrazolin-5-on-Derivate." Archiv der Pharmazie 319, no. 10 (1986): 865–71. http://dx.doi.org/10.1002/ardp.19863191002.

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16

Aggarwal, Shilpy, Deepika Paliwal, Dhirender Kaushik, Girish Kumar Gupta, and Ajay Kumar. "Synthesis, Antimalarial Evaluation and SAR Study of Some 1,3,5-Trisubstituted Pyrazoline Derivatives." Letters in Organic Chemistry 16, no. 10 (2019): 807–17. http://dx.doi.org/10.2174/1570178616666190212145754.

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The synthesis of a novel series of 1,3,5-trisubstitiuted pyrazoline was achieved by refluxing chalcone derivative with different heteroaryl hydrazines. The newly synthesized compounds were characterized by 1H NMR, 13CNMR, mass spectral and elemental analysis data. The synthetic series of novel pyrazoline hybrids was screened for in vitro schizont maturation assay against chloroquine sensitive 3D7 strain of Plasmodium falciparum. Most of the compounds showed promising in vitro antimalarial activity against CQ sensitive strain. The preliminary structure-activity relationship study showed that qu

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17

Yasuhara, Akio, Jason K. Dennis, and Takayuki Shibamoto. "Development and Validation of New Analytical Method for Acrolein in Air." Journal of AOAC INTERNATIONAL 72, no. 5 (1989): 749–51. http://dx.doi.org/10.1093/jaoac/72.5.749.

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Abstract A new method was developed to determine vapor-phase acrolein in air samples. Air containing vapor-phase acrolein was purged into impingers filled with a dichloromethane solution of JV-methylhydrazine. The resulting derivative, l-methyl-2-pyrazoline, was analyzed by gas chromatography using a nitrogen-phosphorous detector (NPD). The detection limit was 8.9 pg 1-methyl-2-pyrazoline, equivalent to 5.9 pg acrolein. The recovery efficiencies of vapor-phase acrolein were 98.0 ± 2.9% and 100.3 ± 3.1% for 150 and 15 μg, respectively. This method was satisfactorily applied for determination of

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18

Hennig, Lothar, Detlef Bendler, Rainer Haeßtner, and Gerhard Mann. "Kompressionseffekte sterisch gehinderter Methylgruppen von Derivaten 4-C-substituierter 2-Pyrazolin-5-one." Zeitschrift für Chemie 28, no. 1 (2010): 27. http://dx.doi.org/10.1002/zfch.19880280109.

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19

Kucybala, Z., and J. Gaca. "Untersuchungen zur Reaktion von Pyrazolon-Azomethin-Farbstoffen mit 2-Pyrazolin-5-on-Derivaten." Journal f�r Praktische Chemie 330, no. 3 (1988): 435–39. http://dx.doi.org/10.1002/prac.19883300314.

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20

Kantlehner, Willi, Jochen Mezger, Rüdiger Stieglitz, et al. "Orthoamide, LXV [1]. Kondensationsreaktionen von Amidinen, Guanidinen, Hydrazin und Hydrazin-Derivaten mit Orthoamiden von Alkincarbonsäuren / Orthoamides,LXV [1]. Condensation Reactions of Amidines, Guanidines, Hydrazine and Hydrazine Derivatives with Orthoamides of Alkyne Carboxylic Acids." Zeitschrift für Naturforschung B 62, no. 8 (2007): 1015–29. http://dx.doi.org/10.1515/znb-2007-0804.

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The orthoamide derivatives 4 react with amidines 10 and guanidines 11 to give 4-dimethylaminopyrimidines 12. The 3-dimethylamino-pyrazoles 13a - c can be prepared from orthoamides 4 and hydrazine. The hydrazine derivative 14, whose constitution was established by crystal structure analysis, is obtained in low yield when hydrazine is added dropwise to a boiling solution of 4d in THF.Methyl- and phenylhydrazine, undergo reaction with the orthoamides 4a, c yielding mixtures of the isomeric pyrazoles 19 and 20. The reaction of 4c with acylhydrazines 21a - e affords the pyrazole 13b. The pyrazole 2

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21

Lhoták, Pavel, Antonín Kurfürst, and Petr Nádeník. "The Synthetic Use of 2-(4'-Acetylbiphenyl-4-yl)-5-phenyl-1,3,4-oxadiazole for Preparation of New Heterocyclic Luminophores." Collection of Czechoslovak Chemical Communications 57, no. 2 (1992): 385–92. http://dx.doi.org/10.1135/cccc19920385.

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2-(4'-Acetylbiphenyl-4-yl)-5-phenyl-1,3,4-oxadiazole (I) was converted into α,β-unsaturated ketone II and pyridinium salt IV, which were used in preparation of triarylpyridines XIII-XIX by Kröhnke's method. Also the diketones V-VIII were obtained from derivative I and served as precursors for the synthesis of pyrazoles IX-XII. The discussion of 1H NMR spectra and luminescent properties of prepared bifluorophoric heterocyclic systems is given.

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22

Muhammad, Zeinab A., Fatimah Alshehrei, Mohie E. M. Zayed, Thoraya A. Farghaly, and Magda A. Abdallah. "Synthesis of Novel Bis-pyrazole Derivatives as Antimicrobial Agents." Mini-Reviews in Medicinal Chemistry 19, no. 15 (2019): 1276–90. http://dx.doi.org/10.2174/1389557519666190313095545.

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Background: bis-heterocycles especially those containing pyrazole moiety display much better antibacterial activity than mono heterocycles. Objective: Herein, we synthesised a series of new bis-pyrazoles and investigated their antimicrobial agents. Methods: A novel series of bis-pyrazole derivatives have been synthesized in good yield by coupling reaction of cyanoacetic acid 4-[(2-cyano-acetyl)-hydrazonomethyl]-benzylidene-hydrazide with a number of diazonium salts of aromatic amines in DMF in the presence of NaOH. Refluxing of the produced hydrazones with hydrazine-hydrate in ethanolic soluti

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23

Patel, Pineshkumar N., and Denish C. Karia. "Synthesis and Antimicrobial Activity of Novel Series of Diversely Substituted Acetyl Pyrazoline Bearing Biphenyl Carbonitrile Motif." International Letters of Chemistry, Physics and Astronomy 69 (August 2016): 42–48. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.69.42.

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Novel series of diversely substituted acetyl pyrazoline having biphenyl carbonitrile motif have been synthesized. The reaction of 2-cyno-4’-bromomethyl biphenyl with1-(4-hydroxy-phenyl)-ethanone resulted in acetophenone derivative of biphenyl-2-carbonitrile. This acetophenone derivative was condensed with substituted aromatic aldehyde in mixed solvent resulted in various substituted chalcones. These chalcones were further cyclized using hydrazine hydrate in presence of glacial acetic acid to produce titled compound derivatives. The chemical structures of synthesized compounds were elucidated b

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24

Farghaly, A. M., I. Chaaban, M. A. Khalil, and A. A. Behkit. "Non-Steroidal Antiinflammatory Agents, II1): Synthesis of Novel Pyrazole and Pyrazoline Derivatives of 4(3H)-Quinazolinone Nicht-steroidale Antiphlogistika, 2. Mitt.1): Synthese neuer Pyrazol- und Pyrazolin-Derivate des 4(3H)-Chinazolinons." Archiv der Pharmazie 323, no. 5 (1990): 311–15. http://dx.doi.org/10.1002/ardp.19903230511.

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25

Fahim, Asmaa Mahmoud, Ahmad Mahmoud Farag, Mohamed Rabie Shaaban, and Eman Ali Ragab. "Synthesis and DFT study of novel pyrazole, thiophene, 1,3-thiazole and 1,3,4-thiadiazole derivatives." European Journal of Chemistry 9, no. 1 (2018): 30–38. http://dx.doi.org/10.5155/eurjchem.9.1.30-38.1675.

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Regioselective facile synthesis of innovative heterocycles from the reaction of 2-cyano-N-cyclohexylacetamide (3) with hydrazonoyl chloride (4) in basic condition afforded amino pyrazole derivative 6. The behavior of acetamide 3 with phenylisothiocyanate in DMF/KOH surveyed by addition of the α-halo ketones to yeild the corresponding thiophene derivative 13a, 13b, 16, 18 and 1,3-thiazoles 21. Reaction of intermediate potassium salt 9 with hydrazonoyl chloride 22a-e furnished the corresponding 1,2,4-thiadiazoles 24a-e. Density functional theory (DFT) calculations at the B3LYP and HF techniques

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26

Taj, Tasneem, Ravindra Kamble, T. M. Gireesh, and Ravindra Hunnur. "Facile syntheses of Mannich bases of 3-[p-(5'-aryl-pyrazolin-3'-yl)]-phenylsydnones, as anti-tubercular and anti-microbial agents, under ionic liquid/TBAB catalytic conditions." Journal of the Serbian Chemical Society 76, no. 8 (2011): 1069–79. http://dx.doi.org/10.2298/jsc100708085t.

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% MIC % antitubercular activity KR nema Novel methylene bridged Mannich bases 2(a-j) were synthesized in good to excellent yields from the pyrazoline derivative (1) using various primary/secondary amines, 37 % formalin in presence of ionic liquids/TBas catalyst. The structures of the newly synthesized compounds were confirmed by IR, 1H- and 13C-NMR and GC-MS spectroscopy, as well as elemental analysis. The title compounds were screened for their anti-tubercular and antimicrobial activities. Some of the compounds exhibited very good anti-tubercular, antifungal and antibacterial activities.

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27

Chen, Kun, Ya-Liang Zhang, Jing Fan, Xiang Ma, Ya-Juan Qin, and Hai-Liang Zhu. "Novel nicotinoyl pyrazoline derivates bearing N-methyl indole moiety as antitumor agents: Design, synthesis and evaluation." European Journal of Medicinal Chemistry 156 (August 2018): 722–37. http://dx.doi.org/10.1016/j.ejmech.2018.07.044.

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28

Ortiz-León, Adriana, J. Martín Torres-Valencia, J. Jesús Manríquez-Torres, et al. "Diastereoselective Addition of Diazomethane to Zaluzanin A." Natural Product Communications 9, no. 6 (2014): 1934578X1400900. http://dx.doi.org/10.1177/1934578x1400900605.

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The diastereoselectivity of diazomethane addition to the conjugated double bond of α,β-unsaturated sesquiterpene lactones was explored using zaluzanin A (1) as a model. Thus, the absolute configuration of 1 was assured by X-ray diffraction analysis including evaluation of Flack and Hooft parameters, and by vibrational circular dichroism spectroscopy of its diacetyl derivative 2, while the absolute configuration of the diazomethane addition product, zaluzanin A pyrazoline (3), was determined by evaluation of the 1H NMR chemical shift changes with respect to 1, and confirmed by X-ray diffraction

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29

Badavath, Vishnu Nayak, Alok Kumar, Surender Singh Jadav, Ashok Kumar Pattnaik, Venkatesan Jayaprakash, and Barij Nayan Sinha. "Synthesis and Antidepressant activity of pyrazoline based MAO-inhibitors." JOURNAL OF PHARMACEUTICAL CHEMISTRY 3, no. 1 (2016): 1. http://dx.doi.org/10.14805/jphchem.2016.art45.

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A series of nine 3-(2-hydroxyphenyl)-5-aryl-N-phenyl-4,5-dihydropyrazole-1-carbothioamide derivative s (3a-3i) that were earlier reported as potent rMAO-A inhibitors were evaluated for their antidepressant activity in Porsolt's behavioral despair test (forced swim test) and Tail Suspension test activity, among them, compounds (3e and 3h) were found to have potent antidepressant activity. Reduction in duration of immobility was significant for all the compounds in Porsolts swim test compared with tail suspension test. 3h was further evaluated for anxiolytic activity in Elevated plus maze and wa

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30

Hartwig de Oliveira, Daniela, Fernanda Severo Sabedra Sousa, Paloma Taborda Birmann, et al. "Evaluation of antioxidant activity and toxicity of sulfur- or selenium-containing 4-(arylchalcogenyl)-1H-pyrazoles." Canadian Journal of Physiology and Pharmacology 98, no. 7 (2020): 441–48. http://dx.doi.org/10.1139/cjpp-2019-0356.

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Pyrazoles represent a significant class of heterocyclic compounds that exhibit pharmacological properties. The present study aimed to investigate the antioxidant potential of pyrazol derivative compounds in brain of mice in vitro and the effect of pyrazol derivative compounds in the oxidative damage and toxicity parameters in mouse brain and plasma of mice. The compounds tested were 3,5-dimethyl-1-phenyl-4-(phenylselanyl)-1H-pyrazol (1a), 3,5-dimethyl-4-(phenylselanyl)-1H-pyrazole (2a), 4-((4-methoxyphenyl)selanyl)-3,5-dimethyl-1-phenyl-1H-pyrazole (3a), 4-((4-chlorophenyl)selanyl)-3,5-dimethy

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31

Czaja, Kornelia, Jacek Kujawski, Elżbieta Jodłowska-Siewert, et al. "On the Interactions of Fused Pyrazole Derivative with Selected Amino Acids: DFT Calculations." Journal of Chemistry 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/8124323.

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Due to the increasing prevalence of neoplasms, there is a permanent need for new selective cytostatic compounds. Anticancer drugs can act in different ways, affecting protein expression and synthesis, including disruption of signaling pathways within cells. Continuing our previous research aiming at elucidating the mechanism of pyrazole’s anticancer activity, we carried out in silico studies on the interactions of fused pyrazole derivative with alanine, lysine, glutamic acid, and methionine. The objective of the study is to improve our understanding of the possible interactions of pyrazole der

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32

CHINNAMANAYAKAR, RAJA, and M. R. EZHILARASI. "Synthesis and Characterization of 2-Phenylpyrazoline Derivatives and Evaluation of their Activities against Antimicrobial and Breast Cancer Cell Line in vitro and in silico Studies." Asian Journal of Chemistry 31, no. 6 (2019): 1311–20. http://dx.doi.org/10.14233/ajchem.2019.21915.

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The new series of 2-phenylpyrazoline derivatives (2a-j) were synthesized and evaluated for their antimicrobial, in silico and in vitro anticancer activity was performed by MTT assay using MDA-MB-231 (human breast adenocarcinoma) cell line. The 2-phenylpyrazoline derivatives (2a-j) were obtained by the cyclization of chalcones with phenylhydrazine hydrochloride. Synthesized compounds were confirmed using FT-IR, 1H NMR and 13C NMR spectral data. Molecular docking studies were carried out using Auto Dock Tool version 1.5.6 and Auto dock version 4.2.5.1 docking program. in silico Docking study, co

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33

Feng, Qi, Wenhui Huan, Jiali Wang, et al. "Cocrystal Assembled by Pyrene Derivative and 1,4-Diiodotetrafluorobenzene via a C=O···I Halogen Bond." Crystals 8, no. 10 (2018): 392. http://dx.doi.org/10.3390/cryst8100392.

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Cocrystal formation is a strategy used to modify the solid-state properties of a given molecule. In this study, a new cocrystal assembled by 1,4-Diiodotetrafluorobenzene (1,4-DITFB) and a pyrene derivative, 1-acetyl-3-phenyl-5-(1-pyrenyl)-pyrazoline (APPP), was synthesized. Due to the twisted structure of APPP, the crystal structure is greatly different with some large π-conjugated compounds, which exhibits edge-to-face π-stacked arrangement between 1,4-DITFB and pyrene rings, rather than the face-to-face π-stacked arrangement. Hirshfeld surface analysis and the shift of characteristic vibrati

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34

Moreno, Leydi, Jairo Quiroga, Rodrigo Abonia, Jonathan Ramírez-Prada, and Braulio Insuasty. "Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents." Molecules 23, no. 8 (2018): 1956. http://dx.doi.org/10.3390/molecules23081956.

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A new series of 1,3,5-triazine-containing 2-pyrazoline derivatives (8–11)a–g was synthesized by cyclocondensation reactions of [(4,6-bis((2-hydroxyethyl)amino)-1,3,5-triazin-2-yl)amine]chalcones 7a–g with hydrazine hydrate and derivatives. Chalcones 7a–g were obtained by Claisen-Schmidt condensation between aromatic aldehydes and triazinic derivative 5, which was synthesized in high yield by a microwave-assisted reaction. Seventeen of the synthesized compounds were selected and tested by the US National Cancer Institute (NCI) for their anticancer activity against 58 different human tumor cell

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Elgemeie, Galal H., Shahinaz H. Sayed, and Peter G. Jones. "True symmetry or pseudosymmetry: 5-amino-1-(4-methylphenylsulfonyl)-4-pyrazolin-3-one and a comparison with its 1-phenylsulfonyl analogue." Acta Crystallographica Section C Crystal Structure Communications 69, no. 1 (2012): 90–92. http://dx.doi.org/10.1107/s0108270112049906.

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The title compound, C10H11N3O3S, (I), crystallizes as the NH tautomer. The two rings subtend an interplanar angle of 72.54 (4)°. An intramolecular hydrogen bond is formed from the NH2group to a sulfonyl O atom. The molecular packing involves layers of molecules parallel to thebcplane atx≃ 0, 1etc., with two classical linear hydrogen bonds (amino–sulfonyl and pyrazoline–carbonyl N—H...O) and a further interaction (amino–sulfonyl N—H...O) completing a three-centre system with the intramolecular contact. The analogous phenyl derivative, (II) [Elgemeie, Hanfy, Hopf & Jones (1998).Acta Cryst.C5

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S. AL-Rawi, Muna, Huda A. Hassan, Dheefaf F. Hassan та Ismaeel Y. Majeed. "New Series of Substituted Heterocyclics Derived from α , β – Unsaturated Ketone and Their Cytotoxic Activity Tumor Cell Lines". Oriental Journal of Chemistry 34, № 6 (2018): 2826–31. http://dx.doi.org/10.13005/ojc/340620.

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The aldol condensation of 2-acetylnaphthalene with 9-anthracene carboxaldehyde afforded α, β-unsaturated keton (1) . New heterocyclic compounds containing: cyclohexenone[2], indazole[3], pyrimidinethion [4], thiazolo fused pyrimidine[5], isoxazoline[6], substituted pyrazoline[7]a-d and pyrimidinone[8] rings system were synthesized from α, β-unsaturated keton[1]. Cyclization of [1] with ethylacetoacetate gave the mentioned heterocycle cyclohexanone [2]. The cyclo condensation of [2] with hydrazine gave the new indazole derivative [3]. furthermore, the reation of [1]with thiourea gives thiopyrmi

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37

Pungot, Noor Hidayah, Najwa Amira Mohamad Latif, and Nur Ain Nabilah Ash'ari. "Synthesis of 1-acetyl-3,5-diphenyl-1H-pyrazole from Chalcone." ASM Science Journal 14 (April 2, 2021): 1–6. http://dx.doi.org/10.32802/asmscj.2020.629.

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The synthesis of chalcone has drawn tremendous interest over the past years due to its wide applications in the pharmaceutical and biological sectors. Indeed, this compound is reported to possess a broad spectrum of promising bioactivities, including anti-inflammatory, anti-invasive, antioxidant, antitumor and antibacterial properties. In this work, chalcone 3 was synthesised via Claisen-Schmidt condensation by using a common starting material of benzaldehyde 1 and acetophenone 2 in the presence of alcoholic alkaline base. Subsequently, 3,5-diphenyl-2-pyrazoline 4 intermediate was successfully

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38

Masaret, Ghada S., and Thoraya A. Farghaly. "Synthesis of 8,10-disubstituted-triazoloperimidines from (E)-3-(dimethylamino)-1-(8- phenyl-8H-[1,2,4]triazolo[4,3-a]perimidin-10-yl)prop-2-en-1-one and Their Antimicrobial Activity." Current Organic Synthesis 15, no. 1 (2018): 126–36. http://dx.doi.org/10.2174/1570179414666170601121137.

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Aim and Objective: Enaminones belay to be extremely stable compounds and constitute a versatile group of salutary precursors for the synthesis of enormous classes of organic compounds. So, in this context, we synthesized a new enaminone, namely, (E)-3-(dimethylamino)-1-(8-phenyl-8H-[1,2,4]triazolo[4,3- a]perimidin-10-yl)prop-2-en-1-one (enaminone 2). Materials and Methods: The reaction of enaminone 2 with different types of hydrazonoyl chlorides or hydrazine hydrate afforded new substituted pyrazoles. Also, the reaction of enaminone with 6-amino-2- thioxopyrimidin-4-one in acetic acid under re

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39

El-Naggar, Mohamed, Amira S. Abd El-All, Shweekar I. A. El-Naem, Mohamed M. Abdalla та Huda R. M. Rashdan. "New Potent 5α- Reductase and Aromatase Inhibitors Derived from 1,2,3-Triazole Derivative". Molecules 25, № 3 (2020): 672. http://dx.doi.org/10.3390/molecules25030672.

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This work describes the utility of pyrazole-4-carbaldehyde 1 as starting material for the synthesis of a novel potent series of 5α-reductase and aromatase inhibitors derived from 1,2,3-triazole derivative. Condensation of 1 with active methylene and different amino pyrazoles produced the respective Schiff bases 2–4, 8 and 9. On the other hand, 1 was reacted with ethyl cyanoacetate and thiourea in one-pot reaction to afford the pyrazolo-6- thioxopyridin-2-[3H]-one (10). Moreover, α–β unsaturated chalcone derivative 11 was prepared via the reaction of compound 1 with P-methoxy acetophenone, whic

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Afsah, Elsayed M., Metwally Hammouda, Mona M. Khalifa, and Essam H. Al-shahaby. "Mannich Bases as Synthetic Intermediates: Alkylation of Amines and Diamines with Bis-ketonic Mannich Bases." Zeitschrift für Naturforschung B 63, no. 5 (2008): 577–84. http://dx.doi.org/10.1515/znb-2008-0516.

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The bis-ketonic Mannich base, N,N-bis(β -benzoylethyl)methylamine hydrochloride (1) reacts with primary arylamines and diamines to give ketonic sec-arylamines 3a - e and 4. The piperidines 7a - c were obtained from 1 and primary alkylamines, whereas the 1,4-diazepine derivative 10 was obtained from 1 and ethylenediamine. Treatment of the bis-base 1,4-di[β -(N-morpholino)propionyl]benzene bis(hydrochloride) (11) with primary arylamines gave the corresponding bis-(sec-arylamines) 12a - b, whereas its reaction with ophenylenediamine afforded the bis[1,5-benzodiazepine] ring system 14. The synthes

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Abdelmohsen, Shawkat A., and Talaat I. El Emary. "SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL PYRAZOLO[3,4-b]PYRIDINES AND THEIR SPIRO-HETEROCYCLIC DERIVATIVES." JOURNAL OF ADVANCES IN CHEMISTRY 10, no. 7 (2014): 2901–15. http://dx.doi.org/10.24297/jac.v10i7.6802.

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The present work describes the synthesis of a novel series of heterocyclic moieties derived from 5-acetylpyrazolo[3,4-b]pyridine (1). The formation of chalcones (2a-d) was utilized to synthesize pyrazoline, isoxazoline and pyrimidine derivatives (3-10). Thiosemicarbazone and semicarbazone (11, 17) were utilized to synthesize other new triazolethiones, thiadiazole and selenadiazole derivatives (11-19). Some new spiro derivatives (22-25) were synthesized by the reaction of chalcone (21) of 1 and isatine with hydrazines, hydroxyl amines and thiourea. Also, The reaction of 1 with cyanoacetyl hydra

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Al-Mehizia, Abdulrahman A., Ahmed H. Bakheit, Seema Zargar, Mashooq A. Bhat, Majid Mohammed Asmari, and Tanveer A. Wani. "Evaluation of Biophysical Interaction between Newly Synthesized Pyrazoline Pyridazine Derivative and Bovine Serum Albumin by Spectroscopic and Molecular Docking Studies." Journal of Spectroscopy 2019 (June 16, 2019): 1–12. http://dx.doi.org/10.1155/2019/3848670.

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In this research, the pyrazoline pyridazine derivative 7-methyl-2-phenyl-4-(3,4,5-trimethoxyphenyl)-2H-pyrazolo[3,4-d]pyridazine (5d) was studied for its interaction with bovine serum albumin (BSA). Various spectroscopic techniques along with molecular docking analysis were utilized to understand the mechanism of interaction. The quenching of BSA fluorescence by using investigational drug 5d was the basic principle for the methodology. Spectrofluorometric methods and UV-absorption studies were conducted for exploration of the 5d and BSA binding mechanism. The fluorescence quenching mechanism i

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Ismail, Magda M. F., Amel M. Farrag, and Marwa F. Harras. "Novel 1,3,4-Triaryl Pyrazoles: Synthesis, QSAR Studies and Cytotoxicity against Breast Cancer." Anti-Cancer Agents in Medicinal Chemistry 19, no. 7 (2019): 948–59. http://dx.doi.org/10.2174/1871520619666190207094610.

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Background:The existence of drug-resistance and lack of selectivity encourages scientists to search for novel and more selective cytotoxic agents.Objective:In this work, novel 1,3,4-triarylpyrazole derivatives were synthesized to study their cytotoxicity on MCF7 (human breast Cell Line). In addition, QSAR studies were performed to show the relation between the cytotoxic activity and the structural features of our new synthesized pyrazole derivatives.Methods:Pyrazole-4-carbaldehyde derivative 3 was utilized as a starting material for the preparation of the new pyarazole derivatives. These targe

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Sophy, Mohamed Ahmed Elian, and Mohamed Ahmed Mahmoud Abdel Reheim. "Synthesis of Some New 1, 3, 4-Oxadiazole, Pyrazole, and Pyrimidine Bearing Thienopyrazole Moieties." Current Organic Synthesis 17, no. 8 (2020): 661–70. http://dx.doi.org/10.2174/1570179417999200730215318.

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Aim and Objective: According to the literature survey, pyrazole is a unique template that is associated with several biological activities. This article highlighted the research work of many researchers reported in the literature for synthesis and different pharmacological activities of the pyrazole nucleus. In the present work, pyrazol- 3-one 1 was reacted with cyanoacetic acid hydrazide and elemental sulfur to afford the corresponding thieno[3,2-c]pyrazol-6-carbohydrazide 3 derivatives. The latter compound reacted with some electrophilic reagents such as DMF-DMA, triethylorthoformate, arylid

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Hargunani, Priya, Nikhil Tadge, Mariangela Ceruso, et al. "Aryl-4,5-dihydro-1H-pyrazole-1-carboxamide Derivatives Bearing a Sulfonamide Moiety Show Single-digit Nanomolar-to-Subnanomolar Inhibition Constants against the Tumor-associated Human Carbonic Anhydrases IX and XII." International Journal of Molecular Sciences 21, no. 7 (2020): 2621. http://dx.doi.org/10.3390/ijms21072621.

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A series of new 3-phenyl-5-aryl-N-(4-sulfamoylphenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide derivatives was designed here, synthesized, and studied for carbonic anhydrase (CAs, EC 4.2.1.1) inhibitory activity against the human (h) isozymes I, II, and VII (cytosolic, off-target isoforms), and IX and XII (anticancer drug targets). Generally, CA I was not effectively inhibited, whereas effective inhibitors were identified against both CAs II (KIs in the range of 5.2–233 nM) and VII (KIs in the range of 2.3–350 nM). Nonetheless, CAs IX and XII were the most susceptible isoforms to this class of in

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Lynda, Golea. "Synthesis, DFT, Molecular docking Analysis and Antibacterial, Antioxidant Activities of tri-substituted pyrazoles." ASM Science Journal 16 (July 15, 2021): 1–7. http://dx.doi.org/10.32802/asmscj.2021.696.

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Pyrazole and its derivatives are contemplated crucial compounds in heterocyclic chemistry which are also used extensively in organic synthesis. These cycles are known for their biological and pharmacological activities. The present investigation is in the interest of some synthesized derivatives containing the pyrazole moieties. (5-Hydroxy-3,5-dimethyl-4,5-dihydro-pyrazol-1-yl)-pyridin-4-yl-methanone (1) and Furan-2-yl-(5-hydroxy-3,5-dimethyl-4,5-dihydro-pyrazol-1-yl)-methanone (2) were synthesized by cyclocondensation of the 1,3-dicarbonyl with the hydrazine derivative with a simple and rapid

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Minnelli, Cristina, Emiliano Laudadio, Roberta Galeazzi, et al. "Synthesis, Characterization and Antioxidant Properties of a New Lipophilic Derivative of Edaravone." Antioxidants 8, no. 8 (2019): 258. http://dx.doi.org/10.3390/antiox8080258.

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As part of a program aimed to obtain antioxidants able to interact with cell membrane, edaravone (EdV, 3-methyl-1-phenyl-2-pyrazolin-5-one), a well-known free radical scavenger, has been modified by alkylation at its allylic position (4) with a C-18 hydrocarbon chain, and the increased lipophilicity has been determined towards the interaction with liposomes. The obtained derivative has been studied by means of density functional theory (DFT) methods in order to characterize its lowest energy conformers and predict its antioxidant properties with respect to the parent compound EdV. The in vitro

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48

Addoum, Boutaina, Bouchra El khalfi, Mohamed Idiken, et al. "Synthesis, Characterization of Pyrano-[2,3-c]-Pyrazoles Derivatives and Determination of Their Antioxidant Activities." Iranian Journal of Toxicology 15, no. 3 (2021): 175–94. http://dx.doi.org/10.32598/ijt.15.3.798.1.

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Background: Antioxidants are developed to assist the immune system and overcome oxidative stress, the aggression of cellular constituents due to imbalance between reactive oxygen species and the inner antioxidant system. The main objective of this study was to search for new and potent antioxidants to protect humans against diseases associated with oxidative stress. Methods: In this study, three pyrano-[2,3-c]-pyrazole derivatives were synthesized via Multicomponent Reaction (MCR) approach and were characterized, using a melting point, High-Performance Liquid Chromatography (HPLC), and spectro

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Kisch, Horst. "Transition Metal Complexes of Diazenes, XL [1] Iron Carbonyl Assisted Formation of Bicyclic 1,2-Dihydropyrazol-3-ones from Pyrazolines and Alkynes." Zeitschrift für Naturforschung B 52, no. 8 (1997): 994–96. http://dx.doi.org/10.1515/znb-1997-0820.

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The oxidative degradation of a tricyclic dicarbonyl iron complex substituted at the diazaferrole ring by ester groups ( 1b ) does not lead to a bicyclic 1,2,3-diazepinone derivative, as reported recently for the case of the phenyl substituted compound (1a ), but affords the bicyclic 4-stilbenyl-1,2-dihydropyrazol-3-one 2b as shown by X-ray structural analysis. Since 1b is obtained by reaction of two different alkynes with a hexacarbonyldiiron complex of the cyclic 1,2-diazene, the over-all reaction formally consists of the addition of CO and two alkyne molecules to an N = N function affording

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Mótyán, Gergő, Mohana Krishna Gopisetty, Réka Eleonóra Kiss-Faludy, et al. "Anti-Cancer Activity of Novel Dihydrotestosterone-Derived Ring A-Condensed Pyrazoles on Androgen Non-Responsive Prostate Cancer Cell Lines." International Journal of Molecular Sciences 20, no. 9 (2019): 2170. http://dx.doi.org/10.3390/ijms20092170.

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Regioselective synthesis of novel ring A-fused arylpyrazoles of dihydrotestosterone (DHT) was carried out in two steps under facile reaction conditions. Aldol condensation of DHT with acetaldehyde afforded a 2-ethylidene derivative regio- and stereo-selectively, which was reacted with different arylhydrazines in the presence of iodine via microwave-assisted oxidative cyclization reactions. The 17-keto analogs of steroidal pyrazoles were also synthesized by simple oxidation in order to enlarge the compound library available for pharmacological studies and to obtain structure–activity relationsh

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