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Journal articles on the topic 'Pyrazoline-5- one derivatives'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

N., Hariraj1* N. Kannappan2 Siju.E.N3. "Synthesis of certain Pyrazoline 5-One Derivatives of 6-Methyl Nicotinicacid and Evaluation of their Antimicrobial activities." Journal of Pharma Research 1, no. 2 (2012): 16–17. https://doi.org/10.5281/zenodo.1098657.

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<strong><em>ABSTRACT</em></strong> <em>Pyrazolines are known to possess a wide variety of biological activities. Due to the wide range of biological activities that Pyrazolines posses, it was our aim to prepare pyrazolin-5-one derivatives containing substituted Nicotinic acid and to explore, their therapeutic advantage. Among the six newly synthesized pyrazoline-5-one derivatives MPZ-1 showed promising antimicrobial activity even at a concentration 250mcg/disc. and MPZ-2 showed moderate antimicrobial activity at a concentration 500mcg/disc.</em> <strong><em>Keywords: </em></strong><em>Pyrazoli

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2

Gineinah, Magdy. "6-, 7- AND 8-(5-ARY L-1-PHENYL-2-PYRAZOLIN-3-LY)IMIDAZO- AND PYRIMIDO[2,1-b]BENZOTHIAZOLES AS NOVEL ANTICONVULSANT AGENTS." Scientia Pharmaceutica 69, no. 1 (2001): 53–61. http://dx.doi.org/10.3797/scipharm.aut-01-06.

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Some new derivatives of 2-amino-5- and 6-(5-aryl-1-phenyl-2-pyrazolin-3-yl)benzothiazole were synthesized from the corresponding aminophenyl compounds by reaction with KSCN/Br2 to build up the benzothiazole ring. The aminophenyl derivatives of pyrazoline were prepared by cyclization with phenylhydrazine of the appropriate 1,3-diphenyl-2-propen-1-one derivatives obtained from arninoacetophenone and differently substituted aldehydes. However, the newly synthesized 2-aminobenzothiazole derivatives of pyrazoline were subjected to cyclization with ethyl brornopyruvate to afford the formation of 6-

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3

Fatmayanti, Baiq Risma, Ahmad Habibie, and Anselmania Kartini Dhey. "SYNTHESIS OF CHALCONE AND PYRAZOLINE DERIVATIVES WITH ACETOPHENONE AND VERATRALDEHYDE AS PRECURSORS." Medical Sains : Jurnal Ilmiah Kefarmasian 9, no. 3 (2024): 655–64. http://dx.doi.org/10.37874/ms.v9i3.1274.

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Chalcones and pyrazolines are heterocyclic compounds with promising biological and pharmaceutical activities. Chalcone and pyrazoline can be found in different sources, such as natural and synthetic compounds. This study aimed to explore the synthesis of chalcone and pyrazoline derivatives with acetophenone and veratraldehyde as precursors. Chalcone was successfully synthesized through the Claissen-Schmidt reaction between acetophenone and veratraldehyde at room temperature 25-30 ºC and mediated by KOH as a base catalyst for 20 hours. The corresponding substituted pyrazoline derivative was als

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4

Mistry, Rakesh N., and K. R. Desai. "Studies on Synthesis of Some Novel Heterocyclic Chalcone, Pyrazoline, Pyrimidine - 2 - One, Pyrimidine - 2 - Thione,para-Acetanilide Sulphonyl and Benzoyl Derivatives and their Antimicrobial Activity." E-Journal of Chemistry 2, no. 1 (2005): 30–41. http://dx.doi.org/10.1155/2005/953107.

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1, 2 - Dichloro benzene on chlorosulphonation by chlorosulphonic acid gives 1, 2 - [dichloro] - benzene sulphonyl chloride which on condensation withp–amino acetophenone gives 1-[acetyl] - 1’ , 2’ - [dichloro] - dibenz sulphonamide derivative. This derivative undergo condensation with 2,4- dichloro benzaldehyde gives 1- [3” - (sub. phenyl) - 2” - propene - 1” - one] - 1’ , 2’ - [dichloro] - dibenz sulphonamide derivative which on reaction with 99% hydrazine hydrate and glacial acetic acid gives 1-[acetyl]-3- [1’ , 2’ - (dichloro) - dibenz sulphonamide] -5 - [2” , 4” - dichloro phenyl] - 2 - py

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5

Al-Smaisim, Rafah F., Redha E. Al-Bayati, and Abdul Hussain K. Sharba. "Synthesis of New Heterocyclic compounds derived from Pyrazoline-5-one compound." Al Mustansiriyah Journal of Pharmaceutical Sciences 9, no. 1 (2011): 123–31. http://dx.doi.org/10.32947/ajps.v9i1.278.

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In this work new heterocyclic pyrazolin derivatives have been synthesized from diazonium chloride salt of 4-aminobenzoic acid: firstly, Azo compounds were prepared from the reaction of an ethanolic solution of sodium acetate and calculated amount of active methylene compound namely, (ethyl acetoacetate)obtain the corresponding hydrazono derivative (1). Secondly, Cyclocondensation reaction of compound (1) with hydrazine hydrate (2) in boiling ethanol affording the corresponding pyrazoline-5-one. Then compound (2) reacted with thionyl chloride to give the corresponding acid chloride derivative(3

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6

Mervat Mohammed K and Tagreed N-A Omar. "Synthesis, Characterization, Anti-Inflammatory, and Antimicrobial Evaluation of New 2-Pyrazolines Derivatives Derived from Guaiacol." Iraqi Journal of Pharmaceutical Sciences( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 32, Suppl. (2023): 254–61. http://dx.doi.org/10.31351/vol32isssuppl.pp254-261.

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Abstract: Chalcones were used to synthesis series of 2-pyrazoline derivatives and evaluated their antimicrobial and anti-inflammatory activities (E)-1,3-diphenylprop-2-en-1-one (1-5) were synthesized by Claisen-Schmidt Condensation method through the reaction of acetophenone with five various para substituted benzaldehyde in presence of KOH, the reaction monitoring by TLC and the result intermediates were checked by melting point and FT-IR Various 2-Pyrazoline derivatives were prepared by one pot reaction that involved the refluxing of (E)-1,3-diphenylprop-2-en-1-one (1–5) an

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7

Sabah, Rusul Saad, Zahraa S. Al-Garawi, and Mahmoud N. Al-jibouri. "The utilities of pyrazolines encouraged synthesis of a new pyrazoline derivative via ring closure of chalcone, for optimistic neurodegenerative applications." Al-Mustansiriyah Journal of Science 33, no. 1 (2022): 21–31. http://dx.doi.org/10.23851/mjs.v33i1.1067.

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Pyrazolines and their derivatives have been extensively studied as coordinated ligands of high potential applications in diverse chemical and biological systems. This work explores some methods of synthesis of pyrazolines, such as the preparation of pyrazole derivatives via chalcones. It also demonstrates that 2-pyrazoline complexes were biologically active and have had a range of clinical applications. Palladium (II) complex of pyrazole was active as antitumor when tested against murine mammary adenocarcinoma (LM3). Copper (II) and Cobalt (II) complex are biologically active in the living sys

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8

El-Ossaily, Y. A. B., R. M. Zaki, and S. A. Metwally. "Investigation and Synthesis of Some Novel Spiro Heterocycles Related to Indoline Moiety." Journal of Scientific Research 6, no. 2 (2014): 293–307. http://dx.doi.org/10.3329/jsr.v6i2.17590.

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Reactions of indole-2,3-dione 1 with 2-mercaptobenzimidazole, o-phenylenediamine, 2-aminophenol, 2-aminobenzothiazole, 2-aminobenzimidazole and 3-methyl-1-phenyl-2-pyrazolin-5-one were carried out to give compounds spiroindolethiazetobenzimidazole 2, spirobenzimidazole(oxazole)indoline 3a,b, benzothiazol(imidazol) iminoindolinone 4a,b and methyloxoindolylidenepyrazolone 5 respectively. Compound 5 was reacted with 2-aminophenol as well as o-phenylenediamine to give new spirooxazepine and diazepine derivatives 6a,b respectively. Reaction of 5 with nitrogen nucleophiles as well as carbon nucleoph

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9

Yuosra K. Alasadi, Farouq Emam Hawais, and Ahmed A. ALKazmi. "Synthesis and Characterization of Some New Pyrazoline Derivatives Containing Azo Group by One Pot Method." Tikrit Journal of Pure Science 23, no. 3 (2018): 67–74. http://dx.doi.org/10.25130/tjps.v23i3.502.

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This research includes the preparation of some of pyrazoline derivatives containing the azo group by one pot method through the treatment of the compound 2-hydroxy-5-(m-tolyldiazenyl) benzaldehyde with p-chlorob enzylchloride to give the compound(1) using the Williamson reaction. The compound (1) is treated with a series of ketones and with phenylhydrazine in the base medium to give new derivatives of pyrazoline (2-11). The synthesized compounds were characterized by elemental analyses and FT-IR, 1H-NMR, 13C-NMR, 13C-DEPT.

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10

Rathinamanivannan, S., K. Megha, Raja Chinnamanayakar, Ashok Kumar, and M. R. Ezhilarasi. "Synthesis and Characterization of 2-Pyrazoline Derivatives and their in silico and in vitro Studies on Antimicrobial and Anticancer Activities." Asian Journal of Chemistry 31, no. 10 (2019): 2191–96. http://dx.doi.org/10.14233/ajchem.2019.22082.

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The new series of 1-(4,5-dihydro-5-phenyl-3-diphenylpyrazol-1-yl)butan-1-one derivatives were synthesized by cyclization method using biphenyl chalcone with n-butyric acid and hydrazine hydrate. The synthesized 1-(4,5-dihydro-5-phenyl-3-diphenylpyrazol-1-yl)butan-1-one derivatives chemical structures were confirmed from spectral data such as FT-IR, 1H and 13C NMR. 2-Pyrazoline derivatives were docked with bacterial (1UAG) and breast cancer (1OQA) protein. Based on high binding affinity score, the best compound was subjected to in vitro anticancer activity by MTT assay. Also, antimicrobial acti

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11

Abeed, Ahmed A. O., Talaat I. El-Emary, and Mohamed S. K. Youssef. "A Facile Synthesis and Reactions of Some Novel Pyrazole-based Heterocycles." Current Organic Synthesis 16, no. 3 (2019): 405–12. http://dx.doi.org/10.2174/1570179416666181210160908.

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<p>Aim and Objective: This work presents the synthetic capability and the exploitation of 1,3-diphenyl- 1H-pyrazole-4-carboxladehyde 1 and 5-diphenyl pyrazolyl-2-pyrazoline analogue 8 to serve as excellent precursors for the synthesis of substituted indol-2,3-dione, trizolo[3,4-a]benzazoles, thiazolo[2,3- a]benzimidazole-3-one, substituted 2-pyrazoline and pyrazole-substituted-pyrazolines using various reagents. </P><P> Materials and Methods: Using chemicals from Aldrich, Fluka, or Merck, and pure solvents, we apply the synthetic procedures for the synthesis of novel heterocy

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12

Ahmed A. ALKazmi, Farouq Emam Hawais, and Yuosra K. Alasadi. "Synthesis and Characterization of some Pyrazoline derivatives from Chalcones containing azo and ether groups." Tikrit Journal of Pure Science 22, no. 9 (2023): 69–75. http://dx.doi.org/10.25130/tjps.v22i9.877.

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A number of 3-(substituted)-5-(2((4-chlorobenzyl)oxy)-5-(m-tolyldizenyl) pheny l) pyrazoline (3a-j) have been synthesized by benzyloxation of hydroxyl group to give the substrate 2-((4-chlorobenzyl)oxy)-5-(m-tolyldizenyl) benzaldehyde (1). The compound (1) has been treated with different substituted acetophenone to give a new series of chalcone derivatives 1-(substituted)-3-(2-((4-chlorobenzyl)oxy)-5-(m-tolyldiazenyl) phenyl) prop-2-en-1-one (2a-j). The chalcone derivatives have been treated with hydrazine hydrate according to Michael addition reaction to afford a series of new pyrazoline deri

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13

Journal, Baghdad Science. "Synthesis of New Heterocyclic Derivatives from 4-(3, 5-Dimethyl-1-phenyl-1H-pyrazol-4-ylazo)- benzoic acid." Baghdad Science Journal 7, no. 1 (2010): 727–36. http://dx.doi.org/10.21123/bsj.7.1.727-736.

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In this work pyrazolin derivatives were prepared from the diazonium chloride salt of 4-aminobenzoic acid. Azo compounds were prepared from the reaction of an ethanolic solution of sodium acetate and calculated amount of active methylene compound namely, acetyl acetone to obtain the corresponding hydrazono derivative (1). Cyclocondensation reaction of compounds (1) with hydrazine hydrate and phenyl hydrazine in boiling ethanol affording the corresponding pyrazoline-5-one derivatives of 4-aminobenzoic acid (2,3). Then compound (3) was reacted with thionyl chloride to give the corresponding acid

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14

Özdemir, Ahmet, Belgin Sever, and Mehlika Dilek Altıntop. "New Benzodioxole-based Pyrazoline Derivatives: Synthesis and Anticandidal, In silico ADME, Molecular Docking Studies." Letters in Drug Design & Discovery 16, no. 1 (2018): 82–92. http://dx.doi.org/10.2174/1570180815666180326152726.

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Background: Azoles are commonly used in the treatment and prevention of fungal infections. They suppress fungal growth by acting on the heme group of lanosterol 14α-demethylase enzyme (CYP51), thus blocking the biosynthesis of ergosterol. </P><P> Objectives: Due to the importance of pyrazolines in the field of antifungal drug design, we aimed to design and synthesize new pyrazoline-based anticandidal agents. Methods: New pyrazoline derivatives were synthesized via the reaction of 1-(chloroacetyl)-3-(2- thienyl)-5-(1,3-benzodioxol-5-yl)-2-pyrazoline with aryl thiols. These compounds

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15

Kaur, Amandeep, Baljeet Kaur, and Monika Gupta. "SYNTHESIS AND BIOLOGICAL EVALUATION OF 1-SUBSTITUTED-2-THIENYL- 5-(4-CHLOROPHENYL) PYRAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS." INDIAN DRUGS 56, no. 06 (2019): 24–30. http://dx.doi.org/10.53879/id.56.06.11849.

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Cancer is not a single disease, but a large group of diseases characterized by uncontrolled, rapid and pathological proliferation of abnormally transformed cells. Pyrazoline is a five-membered heterocyclic ring having two adjacent nitrogen atoms within the ring. It has only one endocyclic double bond and is basic in nature. The present study involves synthesis of 1-substituted-2-thienyl-5-(4-chlorophenyl) pyrazoline derivatives. The synthesized compounds were subjected to anticancer screening against SK-OV-3 cells line to determine the growth inhibitory effects of the compounds. Amongst all th

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16

Abdollahi-Alibeik, Mohammad, Ali Moaddeli, and Kianoosh Masoomi. "BF3 bonded nano Fe3O4 (BF3/MNPs): an efficient magnetically recyclable catalyst for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives." RSC Advances 5, no. 91 (2015): 74932–39. http://dx.doi.org/10.1039/c5ra11343a.

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1,4-Dihydropyrano[2,3-c]pyrazole derivatives were efficiently synthesized in a simple one-pot three-component reaction of various aldehydes with malononitrile and a 2-pyrazoline-5-one in the presence of BF<sub>3</sub>/MNPs as a novel nanostructured, heterogeneous and reusable catalyst.

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17

Mohammed Qadir, Kale, Hawzhin Yassen Hussein, Marlin Yousef Aziz, et al. "Synthesis, molecular docking study and antibacterial activity of new pyrazoline derivatives." Bulletin of the Chemical Society of Ethiopia 39, no. 5 (2025): 955–66. https://doi.org/10.4314/bcse.v39i5.

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In this study, a new series of pyrazoline compounds with five members was synthesized by cyclization of chalcone derivatives in presence of phenyl hydrazine (3a-i). The development began with 4-hydroxy acetophenone, which was benzylated via Williamson ether synthesis to give 1-(4-(benzyloxy) phenyl)-3-phenylprop-2-en-1-one (1), many derivatives of chalcones (2a-i) were synthesized by Claisen-Schmidt condensation of the compound (1) with substituted benzaldehyde, chalcones undergo cyclization with phenyl hydrazine to give target pyrazoline derivatives. The structure of all newly obtained compou

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18

E. Hawaiz, Farouq, and Mohammad K. Samad. "Synthesis and Spectroscopic Characterization of Some New Biological Active Azo–Pyrazoline Derivatives." E-Journal of Chemistry 9, no. 3 (2012): 1613–22. http://dx.doi.org/10.1155/2012/525940.

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A number of 3-[4-(benzyloxy)-3-(2-Chlorophenylazo)-phenyl]-5-(substituted-phenyl)-1-substituted-2-pyrazolines( 4a-j) and (5a-j) have been synthesized by diazotization of 2-chloroaniline and its coupling reaction with 4-hydroxy acetophenone, followed by benzyloxation of the hydroxyl group to give the substrate [4-benzyloxy-3-(2-chlorophenylazo)-acetophenone (1)].The prepared starting material (1) has been reacted with different substituted benzaldehydes to give a new series of chalcone derivatives 1-[(4-benzyloxy)-3-(2-chloro-phenylazo)-phenyl]-3-(substituted phenyl)-2-propen-1-one (3a-j), in h

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19

V., Nagaraju, Srinivasulu R., Doraswamy K., and Venkata Ramana P. "Synthesis, characterization and antibacterial screening of new pyrazole and pyrazoline-5-one derivatives." Journal of Indian Chemical Society Vol. 88, Feb 2011 (2011): 293–98. https://doi.org/10.5281/zenodo.5773547.

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Department of Chemistry, Sri Krishnadevaraya University, Anantapur-515 003, Andhra Pradesh, India Department of Chemistry, Sri Krishnadevaraya University Post-Graduate Centre, Kurnool-518 002, Andhra Pradesh, India <em>E-mail </em>: ramanapv2103@yahoo.com <em>Manuscript received 21 July 2009, revised 10 May 2010, accepted 07 July 2010</em> A series of N' -(p-toluene sulphonyl)-3-methyl-4-(substituted arylhydrazono)-2-pyrazoline-5-ones and N' -(2- hydroxybenzoyl)-3,5-dimethyl-4-(substituted arylazo)pyrazoles have been synthesized and characterized by chemical analysis, IR and <sup>1</su

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20

Al-Ghulikah, H. A., A. S. El-Azab, M. S. AL-Saleem, M. S. AL-Towayan, and S. A. Al-Issa. "Green synthesis, characterization, biological evaluation and docking study of some pyrazoline and pyrimidine derivatives." Research Journal of Chemistry and Environment 25, no. 12 (2021): 88–97. http://dx.doi.org/10.25303/2512rjce8897.

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Green and classical techniques have been utilized for preparing of a variety of aryl - substituted pyrazoline and pyrimidine derivatives (2-8). Reactions of chalcones 1 with semicarbazide and thiosemicarbazide, nicotinic acid hydrazide and amino guanidine hydrochloride afforded the corresponding N-substituted pyrazoline derivatives 2-5. Pyrimidine derivatives 6-8 were achieved via reaction of chalcone derivatives 1 with several reagents namely: guanidine nitrate, thiourea and 6-amino-2-thioxo-2,3- dihydropyrimidin-4(1H)-one under conventional and ultrasonic conditions. Ultrasonic method was fo

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21

Shailesh, H. Shah, and S. Patel Pankaj. "Synthesis and antimicrobial activity of azetidin-2-one containing pyrazoline derivatives." Journal of Indian Chemical Society Vol. 90, Jun 2013 (2013): 863–66. https://doi.org/10.5281/zenodo.5773732.

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Department of Chemistry, Patel J.B.R. Arts, Patel A.M.R. Commerce & Patel J.D.K.D. Science College, Borsad-388 540, Gujarat, India <em>E-mail </em>: shailchem@yahoo.com Department of Chemistry, Sheth L.H. Science College, Mansa, Gujarat, India <em>Manuscript received online 25 July 2012, revised 26 July 2012, accepted 31 July 2012</em> Pyrazolines are well-known and important nitrogen containing 5-membered heterocyclic compounds and various methods have been worked out for their synthesis. A new series of 3-chloro-1-{ 4-[5-(substituted phenyl)-4,5-dihydropyrazol-3-yl]phenyl}-4-(4-choloroph

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22

B. jadhav, S., R. A. shastri, K. V. gaikwad, and S. V. gaikwad. "Synthesis and Antimicrobial Studies of Some Novel Pyrazoline and Isoxazoline Derivatives." E-Journal of Chemistry 6, s1 (2009): S183—S188. http://dx.doi.org/10.1155/2009/361564.

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A new series of 1H-3-(4’-substituted phenyl)-5-(6’’-methoxy napthaline)-2-pyrazolines (4a-e) and 1H-3-(4’-substituted phenyl)-5-(6’’-methoxynapthaline)-2-isoxazolines (5a-e) were synthesized by reacting 1-(4’-substituted phenyl)-3-(6’’-methoxynapthaline)-2-propene-1-one (3a-e) with hydrazine hydrate and hydroxylamine hydrochloride respectively. All these compounds were characterized by means of their IR,1H NMR, spectroscopic data and microanalysis. All the synthesized products were evaluated for their antimicrobial activity. All the compounds exhibited significant to moderate antimicrobial act

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Altıntop, Mehlika Dilek. "Synthesis, In vitro and In silico Evaluation of a Series of Pyrazolines as New Anticholinesterase Agents." Letters in Drug Design & Discovery 17, no. 5 (2020): 574–84. http://dx.doi.org/10.2174/1570180816666190618111023.

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Background: Pyrazolines, electron-rich nitrogen carriers, are of great importance due to their potential applications for the treatment of many diseases including inflammation, infectious diseases and neurodegenerative disorders. Objectives: The purpose of this work was to synthesize new pyrazoline derivatives and evaluate their anticholinesterase effects. Methods: 1-Aryl-5-[4-(piperidin-1-yl)phenyl]-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazoles (1-7) were synthesized via the treatment of 1-(3,4-dimethoxyphenyl)-3-[4-(piperidin-1-yl)phenyl]prop-2- en-1-one with arylhydrazine hydrochloride d

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Komal, Savaliya, and S. Patel Pankaj. "Synthesis and Biological evaluation Of Some New Benzoyl Pyrazole Derivatives bearing a 6,8-Dibromo-2-methylquinazolin-4-one Moiety." Der Pharma Chemica 14, no. 2 (2022): 6. https://doi.org/10.4172/0975-413X.14.2.1-5.

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A new series of 3-[4-(1-benzoyl-5-(substitutedphenyl)-4,5-dihydro-pyrazol-3-yl)phenyl]-6,8-dibromo-2-methylquinazolin-4-one have been synthesized by the condensation reaction of 6,8-dibromo-3-{4-[5-(substitutedphenyl)-4,5-dihydro-pyrazol-3-yl]phenyl}-2-methylquinazolin-4-one with benzoyl chloride by using pyridine as a solvent. The intermediate have been synthesized by refluxation of 6,8-dibromo-3-{4-[3- (substitutedphenyl)prop-2-enoyl]phenyl}-2-methylquinazolin-4-one (0.01M) and 99% hydrazine hydrate (0.015M) by using ethanol (50ml) as a solvent with various aldehydes. The chemical structures

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Savaliya, Komal, and S. Patel Pankaj. "Synthesis and Biological evaluation Of Some New Benzoyl Pyrazole Derivatives bearing a 6,8-Dibromo-2-methylquinazolin-4-one Moiety." Der Pharma Chemica 14, no. 2 (2022): 6. https://doi.org/10.5281/zenodo.13353950.

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A new series of 3-[4-(1-benzoyl-5-(substitutedphenyl)-4,5-dihydro-pyrazol-3-yl)phenyl]-6,8-dibromo-2-methylquinazolin-4-one have been synthesized by the condensation reaction of 6,8-dibromo-3-{4-[5-(substitutedphenyl)-4,5-dihydro-pyrazol-3-yl]phenyl}-2-methylquinazolin-4-one with benzoyl chloride by using pyridine as a solvent. The intermediate have been synthesized by refluxation of 6,8-dibromo-3-{4-[3- (substitutedphenyl)prop-2-enoyl]phenyl}-2-methylquinazolin-4-one (0.01M) and 99% hydrazine hydrate (0.015M) by using ethanol (50ml) as a solvent with various aldehydes. The chemical structures

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26

D., N. Satyanarayana, K. Ravindranath L., Ravi Sankar T., and Venkata Ramana P. "Electrochemical behaviour of 1-benzenesulfonyl-3-benzenesulfanantido-4-(4'-substituted- arylhydrazono)-2-pyrazolin-5-ones." Journal of India Chemical Society Vol 81, Aug 2004 (2004): 654–59. https://doi.org/10.5281/zenodo.5830003.

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Department of Chemistry, Sri Krishnadevaraya University, Anantapur-515 003, India Department of Chemistry, Sri Krishnadevaraya University Post-Graduate Centre, Kurnool-518 002, India <em>E-mail</em> : ramanapeddakotla@yahoo.co.in         <em>Fax</em>: 91-8518-276183 <em>Manuscript received 4 October 2002. revised 10 December 2003. accepted 10 March 2004</em> The electrochemical behaviour of 1- benzenesulfonyl-3-benzenesulfanamido-4- (4' -substituted-arylhydrazono )-2-pyrazolin-5- ones has been investigated at dme and ge electrodes in buffer solutions of p

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27

Oral, Basak. "The synthesis and antitubercular activity of substituted hydrazone,2-pyrazoline-5-one and 2-isoxazoline-5-one derivatives possessing 1,3,4-thiadiazole moiety." MARMARA PHARMACEUTCAL JOURNAL 3, no. 16 (2012): 222–28. http://dx.doi.org/10.12991/201216402.

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Prabha, B., C. Raja, S. Nathiya, and M. R. Ezhilarasi. "Synthesis, in vitro and in silico Studies of Naphthalene Pyrazoline Prop-2-en-1-one Derivatives." Asian Journal of Chemistry 32, no. 8 (2020): 1849–56. http://dx.doi.org/10.14233/ajchem.2020.22654.

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The synthesized new naphthalene pyrazoline prop-2-en-1-one derivatives (NDPP 1-8) were obtained by the Michael addition reaction of ethyl propanoate, hydrazine hydrate with NPD as a multicomponent scaffold. (E)-1-(naphthalen-3-yl)-3-phenylprop-2-en-1-one (NPD) was formed from 2-acetyl naphthalene and substituted aldehyde via Claisen-Schmidt condensation reaction. The NDPP skeleton structures were confirmed by infrared, 1H & 13C NMR spectral data and elemental analysis. The structure of NDPP compounds was subjected to molecular docking and ADME studies. The result of ADME prediction, compou

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Nagaraju, V., R. Srinivasulu, K. Doraswamy, and P. Venkata Ramana. "ChemInform Abstract: Synthesis, Characterization and Antibacterial Screening of New Pyrazole (VI) and Pyrazoline-5-one Derivatives (III)." ChemInform 43, no. 3 (2011): no. http://dx.doi.org/10.1002/chin.201203106.

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Güniz Küçükgüzel, Ş., Sevim Rollas, Habibe Erdeniz, Muammer Kiraz, A. Cevdet Ekinci, and Aylin Vidin. "Synthesis, characterization and pharmacological properties of some 4-arylhydrazono-2-pyrazoline-5-one derivatives obtained from heterocyclic amines." European Journal of Medicinal Chemistry 35, no. 7-8 (2000): 761–71. http://dx.doi.org/10.1016/s0223-5234(00)90179-x.

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Abdula, Ahmed Mutanabbi, Ghazwan Ali Salman, and Hamid H. Mohammed. "Comparative Study on Conventional and Ultrasound Irradiation Promoted Synthesis of 2,3-Disubstitutedquinoxaline Derivatives." Al-Mustansiriyah Journal of Science 28, no. 3 (2018): 141. http://dx.doi.org/10.23851/mjs.v28i3.207.

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A series of ten chalcone-substituted quinoxalines (4a-e), (3a-e) starting from 1-(phenylquinoxalin-2-yl)ethanone and 1-(3-methylquinoxalin-2-yl)ethanone have been synthesized using conventional heating and ultrasound-assisted methods. Furthermore, novel of five quinoxaline derivatives including pyrazoline, isoxazole, pyrimidin-2-one, N-acylpyrazoline and pyridin-2-one moieties were also prepared from the reaction of chalcone compound 4a with different cyclization reagents using the same strategy. The structures of all synthesized compounds were established on the basis of FT-IR, 1H-NMR and 13C

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32

Maurya, Ram C., and Deen D. Mishra. "Synthesis and physico-chemical studies of some novel mixed-ligand cyanonitrosyl {CrNO}5 complexes of chromium with 2-3-pyrazoline-5-one derivatives." Transition Metal Chemistry 12, no. 6 (1987): 551–52. http://dx.doi.org/10.1007/bf01023847.

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33

Kuecuekguezel, S. Gueniz, Sevim Rollas, Habibe Erdeniz, Muammer Kiraz, A. Cevdet Ekinci, and Aylin Vidin. "ChemInform Abstract: Synthesis, Characterization and Pharmacological Properties of Some 4-Arylhydrazono-2-pyrazoline-5-one Derivatives Obtained from Heterocyclic Amines." ChemInform 31, no. 45 (2000): no. http://dx.doi.org/10.1002/chin.200045136.

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Maurya, R. C., R. Verma, and D. Sutradhar. "Synthesis, Magnetic, and Spectral Studies of Mixed‐Ligand Complexes of Nickel(II) Involving Some Chelating 4‐Oximino‐2‐pyrazoline‐5‐one Derivatives." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 33, no. 3 (2003): 435–51. http://dx.doi.org/10.1081/sim-120019997.

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35

Maurya, R. C., D. O. Mishra, P. K. Trivedi, S. Mukherjee, and D. K. Shrivastara. "Synthesis and Characterization of Some Hovel Pehta-Coordihated Mixed-Ligakd Derivatives of Zinc(II)-bis(Acetylacetone) and-bis(Acetoacetanilide) Chelates with 2/3-Pyrazoline-5-One Derivatives." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 22, no. 4 (1992): 403–14. http://dx.doi.org/10.1080/15533179208020474.

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Maurya, R. C., D. D. Mishra, P. K. Trivedi, and A. Gupta. "Synthesis, Magnetic and Spectral Studies of Some Mixed-Ligand Chelates of Mercury(II) with Acetoacetanilide/o-hydroxyacetophenone and 2/3-Pyrazoline-5-one Derivatives." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 24, no. 1 (1994): 17–28. http://dx.doi.org/10.1080/00945719408000091.

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Maurya, R. C., R. Verma, P. K. Trivedi, and H. Singh. "Synthesis, Magnetic and Spectral Studies of Some Mixed-Ligand Chelates of Bis(2-Hydroxyacetphenonauam)Copper(II) with 2- or 3-Pyrazoline-5-One Derivatives." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 28, no. 2 (1998): 311–29. http://dx.doi.org/10.1080/00945719809351906.

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Maurya, R. C., D. D. Mishra, S. Mukherjee, P. K. Trivedi, and S. K. Jaiswal. "Synthesis and Structural Investigation of Some Mixed-Ligand Cyanonitrosyl {Mo(NO)2}6Complexes of Molybdenum with some 2 or 3-Pyrazoline-5-one Derivatives." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 23, no. 5 (1993): 723–34. http://dx.doi.org/10.1080/15533179308016855.

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Maurya, R. C., D. D. Mishra, and V. Filial. "Synthesis and Characterization of Some Mixed-Ligand Thiocyanato Complexes of Cadmium(II), Mercury(II), Zinc(II) with 2-or 3-Pyrazoline-5-One Derivatives." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 25, no. 1 (1995): 139–50. http://dx.doi.org/10.1080/15533179508218209.

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Maurya, R. C., D. D. Mishra, R. Rathore, and S. Jain. "Synthesis, Magnetic and Spectral Studies of Some Mixed-Ligand Complexes of Copper(II) and Cobalt(II) with Schiff Bases and 2- or 3-Pyrazoline-5-one Derivatives." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 24, no. 3 (1994): 427–39. http://dx.doi.org/10.1080/00945719408000122.

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Maurya, R. C., J. Chourasia, M. H. Martin, S. Roy, A. K. Sharma, and P. Vishwakarma. "Dioxomolybdenum(VI) chelates of bioinorganic, catalytic, and medicinal relevance: Studies on some cis-dioxomolybdenum(VI) complexes involving O, N-donor 4-oximino-2-pyrazoline-5-one derivatives." Arabian Journal of Chemistry 8, no. 3 (2015): 293–306. http://dx.doi.org/10.1016/j.arabjc.2011.01.010.

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42

Maurya, R. C., J. Dubey, and B. Shukla. "A Sincle-Step and Virtually Single Pot Synthesis of some Cynonitrosyl {Mn(NO)2}7Complexes of Manese(O) Involving 2/3-Pyrazoline-5-One Derivatives Directly from Manganate(VII), and Their Characterization." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 28, no. 7 (1998): 1159–71. http://dx.doi.org/10.1080/00945719809349396.

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43

Gil-Ordóñez, Marta, Camille Aubry, Cristopher Niño, Alicia Maestro, and José M. Andrés. "Squaramide-Catalyzed Asymmetric Mannich Reaction between 1,3-Dicarbonyl Compounds and Pyrazolinone Ketimines: A Pathway to Enantioenriched 4-Pyrazolyl- and 4-Isoxazolyl-4-aminopyrazolone Derivatives." Molecules 27, no. 20 (2022): 6983. http://dx.doi.org/10.3390/molecules27206983.

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A series of N-Boc ketimines derived from pyrazolin-5-ones have been used as electrophiles in enantioselective Mannich reactions with different 1,3-dicarbonyl compounds. This method provides a direct pathway to access the 4-amino-5-pyrazolone derivatives bearing a quaternary substituted stereocenter and containing two privileged structure motifs, the β-diketone and pyrazolinone substructures. The adducts were obtained in excellent yields (up to 90%) and enantioselectivities (up to 94:6 er) by employing a very low loading of 2 mol% of a quinine-derived bifunctional squaramide as an organocatalys

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A. Avery, Mitchell, Jae-Chul Jung, and E. Blake Watkins. "Synthesis and Cyclization Reaction of Pyrazolin-5-one Derivatives." HETEROCYCLES 65, no. 1 (2005): 77. http://dx.doi.org/10.3987/com-04-10216.

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Jung, Jae C., E. Blake Watkins, and Mitchell A. Avery. "EFFICIENT SYNTHESIS OF 4-ETHOXYCARBONYL PYRAZOLIN-5-ONE DERIVATIVES." Synthetic Communications 32, no. 24 (2002): 3767–77. http://dx.doi.org/10.1081/scc-120015395.

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46

Liu, Man, Chen-Fei Liu, Jing Zhang, Yan-Jun Xu, and Lin Dong. "Correction: Metal-free tandem reaction synthesis of spiro-cyclopropyl fused pyrazolin-5-one derivatives." Organic Chemistry Frontiers 6, no. 7 (2019): 1064–65. http://dx.doi.org/10.1039/c9qo90021g.

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47

Chauhan, Pankaj, Suruchi Mahajan, and Dieter Enders. "Asymmetric synthesis of pyrazoles and pyrazolones employing the reactivity of pyrazolin-5-one derivatives." Chemical Communications 51, no. 65 (2015): 12890–907. http://dx.doi.org/10.1039/c5cc04930j.

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The various catalytic asymmetric strategies employing organo- and metal-catalysts utilized pyrazolin-5-one derivatives for the synthesis of potentially bioactive enantiopure pyrazoles and pyrazolones are presented.

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48

RAJEEV, JAIN, and K. PARDASANI H. "Synthesis of some New Pyrazole and Pyrazolin-5-one Derivatives of Sulphonamides." Journal of Indian Chemical Society Vol. 68, Jul 1991 (1991): 415–16. https://doi.org/10.5281/zenodo.6158217.

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School of Studies in Chemistry, Jiwaji University, Gwalior-474 011 <em>Manuscript received 17 January 1991, revised 17 June 1991, accepted 26 June 1991</em> Synthesis of some New Pyrazole and Pyrazolin-5-one Derivatives of Sulphonamides.

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Yagi, Kazuo, Akira Numata, Norihiko Mimori, Toshiro Miyake, Kazutaka Arai, and Shigeru Ishii. "Synthesis and insecticidal activity of novel 1,3,4-oxadiazolin-5-one and pyrazolin-5-one derivatives." Pesticide Science 55, no. 2 (1999): 161–65. http://dx.doi.org/10.1002/(sici)1096-9063(199902)55:2<161::aid-ps881>3.0.co;2-m.

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50

C., P. SINGH. "Synthesis of N1-(2-Pyridinecarbony 1)-3-methyl-4(substituted-hydrazono)-2-pyrazolin-5-one." Journal of Indian Chemical Society Vol. 62, Mar 1985 (1985): 222–23. https://doi.org/10.5281/zenodo.6322071.

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Chemical Laboratories, Sahu Jain College, Najibabad-248 763 <em>Manuscript received 27 </em>April <em>1981, accepted 25 February 1985</em> 2-Pyridinecarboxylic acid hydrazide and their derivatives are generally used as antibacterial agent. N<sup>1</sup>-(2-Pyridinecarbonyl)-3-methyl-4-substituted hydrazono)-2-pyrazolin-5-one and their derivatives have been synthesised. Their Rf values, chemical analysis, it and nmr spectra are recorded.

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