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Journal articles on the topic 'Pyrazolines isoxazoles'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Kidwai, Mazaahir, Shuchi Kukreja, and Ruby Thakur. "K2CO3-Mediated Regioselective Synthesis of Isoxazoles and Pyrazolines." Letters in Organic Chemistry 3, no. 2 (2006): 135–39. http://dx.doi.org/10.2174/157017806775224170.

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2

Solankee, Anjani, and Riki Tailor. "Synthesis, Characterisation and Biological Screening of s-Triazine Based Chalcones and its Derivatization into Phenyl Pyrazolines, Isoxazoles." International Letters of Chemistry, Physics and Astronomy 47 (February 2015): 109–19. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.47.109.

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Heterocyclic derivatives such as phenyl pyrazolines and isoxaxoles were prepared from s - triazine based chalcones. Chalcones (A1 - A5) are synthesised by the reaction of compound (V) with various aromatic aldehydes. Moreover, further reaction of chalcones with phenyl hydrazine hydrochloride and hydroxylamine hydrochloride in the presence of alkali gives phenyl pyrazolines (A6 - A10) and isoxazoles (A11 - A15) derivatives respectively. The structures of the newly synthesised compounds were confiremed by spectroscopic (IR, 1H NMR, 13C NMR) and elemental analysis. All the newly synthesised compo

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3

Solankee, Anjani, and Riki Tailor. "Synthesis, Characterisation and Biological Screening of s-Triazine Based Chalcones and its Derivatization into Phenyl Pyrazolines, Isoxazoles." International Letters of Chemistry, Physics and Astronomy 47 (February 24, 2015): 109–19. http://dx.doi.org/10.56431/p-jy3j82.

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Heterocyclic derivatives such as phenyl pyrazolines and isoxaxoles were prepared from s - triazine based chalcones. Chalcones (A1 - A5) are synthesised by the reaction of compound (V) with various aromatic aldehydes. Moreover, further reaction of chalcones with phenyl hydrazine hydrochloride and hydroxylamine hydrochloride in the presence of alkali gives phenyl pyrazolines (A6 - A10) and isoxazoles (A11 - A15) derivatives respectively. The structures of the newly synthesised compounds were confiremed by spectroscopic (IR, 1H NMR, 13C NMR) and elemental analysis. All the newly synthesised compo

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4

Muna, A. Othman Salem, A. A. Mageed Hana, S. Muftah Huda, F. El Ezabi Reda та A. Khaled Fayrouz. "Synthesis and characterization of some new heterocyclic compounds from α, β- unsaturated carbonyl system". Synthesis and characterization of some new heterocyclic compounds from α, β- unsaturated carbonyl system 3, № 1 (2021): 56–63. https://doi.org/10.36811/ojpsr.2021.110015.

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An efficient and facile one pot synthesis of 3,4-dihydropyrimidinones (Belinelli compound) from furfural, acetylacetone and urea under solvent free conditions was performed, resulted in promising yield. These compounds reacted with benzaldehyde and furfural to give the corresponding chalcones. Chalcones are used to synthesize several derivatives like pyrazolines isoxazoles and pyrimidines having different heterocyclic ring systems. https://www.raftpubs.com/ojpsr-pharmaceutical-science-and-research/articles/ojpsr_raft1015.php

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5

D., H. Vyas, D. Tala S., F. Dhaduk M., D. Akbari J., and S. Joshi H. "Synthesis, antitubercular and antimicrobial activities of some new pyrazoline and isoxazole derivatives." Journal of Indian Chemical Society Vol. 84, Nov 2007 (2007): 1140–44. https://doi.org/10.5281/zenodo.5824658.

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Department of Chemistry, Saurashtra University, Rajkot-360 005, Gujarat, India <em>E-mail </em>: drhsjoshi49@gmail.com <em>Manuscript received 23 November 2006, revised 6 June 2007, accepted 17 August 2007</em> Cyclocondensation of hydrazine hydrate with (2<em>E</em>)-1-(3,5 dibromo-4-methoxyphenyl)-3-aryl-prop-2-en-1-ones (1a-j) in glacial acetic acid afford corresponding 1-acetyl-3-(3,5-dibromo-4-methoxyphenyl)-5-aryl-4,5-dihydro-1<em>H</em>-pyrazoles (2a-j). While the compounds 1a-j on reaction with hydroxylamine hydrochloride in presence of acetic acid and sodium acetate to give 3-(3,

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6

SHAH, M., P. PATEL, S. KORGAOKAR, and H. PAREKH. "ChemInform Abstract: Synthesis of Pyrazolines, Isoxazoles and Cyanopyridines as Potential Antimicrobial Agents." ChemInform 28, no. 13 (2010): no. http://dx.doi.org/10.1002/chin.199713029.

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7

Abbas Bukhari, Syed, Ibrahim Jantan, Lam Wai, Nordin Lajis, Faridah Abbas, and Malina Jasamai. "Synthesis and Effects of Pyrazolines and Isoxazoles on the Phagocytic Chemotaxis and Release of Reactive Oxygen Species by Zymosan Stimulated Human Neutrophils." Medicinal Chemistry 9, no. 8 (2013): 1091–98. http://dx.doi.org/10.2174/1573406411309080011.

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8

Nancy, Sakshi Chaudhary, Deepak Kumar, and Archana. "Synthesis and Anti-inflammatory Activity of Newer Indolyl Pyrazolines and Indolyl Isoxazolines." Asian Journal of Organic & Medicinal Chemistry 7, no. 1 (2022): 79–83. http://dx.doi.org/10.14233/ajomc.2022.ajomc-p365.

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Various 5-substituted aryl-3-(2′-carboxy-5′-methoxyindolyl)-2-pyrazolines (9-15) and 5-substituted aryl-3-(2′-carboxy-5′-methoxyindolyl)isoxazolines (16-22) have been synthesized by the cyclization of compounds 1-(2′-carboxyl-5′-methoxyindolyl-3-arylidenyl chalcones (2-8) by treating them with hydrazine hydrate/glacial acetic acid and hydroxylamine hydrochloride/2% NaOH, respectively and TLC checked for their purity. Structure of all these newly synthesized compounds was characterized by elemental (C, H, N) analysis and IR and 1H NMR spectroscopy. All the synthesized compounds were tested for

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9

Saroja, T., R. M. Ezhilarasi, V. Selvamani, and S. Mahalakshmi. "Synthesis, Characterization and In-Silico Analysis of New 2-Pyrazolines." Journal of Scientific Research 13, no. 1 (2021): 183–94. http://dx.doi.org/10.3329/jsr.v13i1.46995.

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Heterocyclic compounds such as pyrazolines, pyrimidines, oxazole and isoxazole exhibit different pharmacological activities. The current study involves synthesis of new 2-pyrazolines. The synthesis involves the cyclocondensation reaction of substituted chalcones with (4-fluorophenylthio)acetic acid hydrazide (FTAH) under reflux. The chalcones (C1-C7 / 1a-1g) were synthesized from the reaction of substituted acetophenone with substituted benzaldehyde and FTAH was prepared from 4-fluro thiophenol. New 2-pyrazolines were obtained in good yields (60-70 %). All the compounds were characterized by F

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10

Saroja, T., R. M. Ezhilarasi, V. Selvamani, and S. Mahalakshmi. "Synthesis, Characterization and In-Silico Analysis of New 2-Pyrazolines." Journal of Scientific Research 13, no. 1 (2021): 183–94. http://dx.doi.org/10.3329/jsr.v13i1.46995.

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Heterocyclic compounds such as pyrazolines, pyrimidines, oxazole and isoxazole exhibit different pharmacological activities. The current study involves synthesis of new 2-pyrazolines. The synthesis involves the cyclocondensation reaction of substituted chalcones with (4-fluorophenylthio)acetic acid hydrazide (FTAH) under reflux. The chalcones (C1-C7 / 1a-1g) were synthesized from the reaction of substituted acetophenone with substituted benzaldehyde and FTAH was prepared from 4-fluro thiophenol. New 2-pyrazolines were obtained in good yields (60-70 %). All the compounds were characterized by F

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11

FAWI, M., and EL-LATIF ABD. "A Study on 1-Phenyl-3-methyl-5-chloropyrazole-4-carboxaldehyde. Synthesis of fused Pyrazole, Isoxazole, Pyrimidine and Pyridine-[2,3-d]pyrazoline Derivatives." Journal of Indian Chemical Society Vol. 71, Oct 1994 (1994): 631–33. https://doi.org/10.5281/zenodo.5896706.

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Chemistry Department, Aswan Faculty of Science, Aswan, Egypt <em>Manuscript received 28 February 1992, revised 29 March 1993, accepted 30 July 1993</em> A Study on 1-Phenyl-3-methyl-5-chloropyrazole-4-carboxaldehyde. Synthesis of fused Pyrazole, Isoxazole, Pyrimidine and Pyridine-[2,3-<em>d</em>]pyrazoline Derivatives.

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12

Hu, Xiao-Qiang, Guoqiang Feng, Jia-Rong Chen, et al. "PhI(OAc)2-mediated functionalisation of unactivated alkenes for the synthesis of pyrazoline and isoxazoline derivatives." Organic & Biomolecular Chemistry 13, no. 11 (2015): 3457–61. http://dx.doi.org/10.1039/c5ob00029g.

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13

Venkateshwarlu, G., E. Rajanarendar, C. J. Rao, and A. Krishna Murty. "SYNTHESIS OF ISOXAZOLYL 2-PYRAZOLINES." Organic Preparations and Procedures International 20, no. 4 (1988): 401–4. http://dx.doi.org/10.1080/00304948809355883.

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14

Padmavathi, V., R. P. Sumathi, N. Chandrasekhar Babu, and D. Bhaskar Reddy. "1,3-Dipolar Cycloaddition of Dipolar Reagents to Bifunctional Olefins in the Presence of Chloramine-T (CAT)." Journal of Chemical Research 23, no. 10 (1999): 610–11. http://dx.doi.org/10.1177/174751989902301012.

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2-Pyrazolines and 2-isoxazolines are prepared by the reaction of araldehyde hydrazones and araldoximes with bifunctional olefins in the presence of chloramine-T, which also functions as a reagent for aromatization of the former.

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15

Kamel, M. M., K. Z. Gadalla, W. S. El-Hamouly, and M. T. El-Wassimi. "Some Reactions with 4-(p-CinnamoylaniIino)quinolines." Zeitschrift für Naturforschung B 40, no. 5 (1985): 661–63. http://dx.doi.org/10.1515/znb-1985-0517.

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Abstract For possible biological activity, the title compounds were prepared and allowed to condense with hydrazine hydrate, phenyl hydrazine, hydroxylamine HCl, urea and thiourea to give the pyrazolines 3, isoxazolines 4, oxo and thioxopyrimidines 5, respectively.

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16

M.D., ANKHIWALA, and V. HATHI M. "Synthesis and Antibacterial Activity of some 1-Phenyl-3,5- diaryl-2-pyrazolines and 3,5-Diaryl-2-isoxazolines." Journal of Indian Chemical Society Vol. 71, Sep 1994 (1994): 587–89. https://doi.org/10.5281/zenodo.5896364.

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Department of Chemistry, R. R. Mehta College of Science, Palanpur-385 002 <em>Manuscript received 12 August 1991, revised 28 June 1993, accepted 30 June 1993</em> Synthesis and Antibacterial Activity of some 1-Phenyl-3,5-diaryl-2-pyrazolines and 3,5-Diaryl-2-isoxazolines.

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17

Journal, Baghdad Science. "Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents." Baghdad Science Journal 13, no. 3 (2016): 568–77. http://dx.doi.org/10.21123/bsj.13.3.568-577.

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In this paper some chalcones (C1-C8) are prepared based on the reaction of one mole of substituted acetophenone with one mole of substituted benzaldehydes in the presence of (40%) sodium hydroxide as a base. Pyrazolines (P1–P8) are prepared from the reaction of chalcones (C1-C8) with hydrazine hydrate. Isoxazoline (I1-I8) is prepared from the reaction of chalcones (C1-C8) with hydroxyl amine hydrochloride in the presence of (10%) sodium hydroxide as a base. These compounds are characterized by using various physical and spectral methods. The compounds are screened for their in vitro antibacter

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18

Reddy, D. Bhaskar, A. Somasekhar Reddy, and A. Padmaja. "Synthesis of Novel Spiro Tetrahydrothiapyrano-Isoxazolines and Pyrazolines." Synthetic Communications 29, no. 24 (1999): 4433–42. http://dx.doi.org/10.1080/00397919908086607.

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19

Leitão, Emília P. T. "Chalcones: Retrospective Synthetic Approaches and Mechanistic Aspects of a Privileged Scaffold." Current Pharmaceutical Design 26, no. 24 (2020): 2843–58. http://dx.doi.org/10.2174/1381612826666200403124259.

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This review summarizes the synthetic methodologies used in the last 25 years for the synthesis of chalcones, which are a class of flavonoids having a 1,3-diphenyl-2-propene-1-one backbone. These compounds are considered a hot topic in the field of medicinal chemistry, due to their pharmacological activity and because they are important precursors for the synthesis of heterocyclic compounds with therapeutic applications such as: flavones, flavanones, isoxazolines, benzothiazepines, pyrimidines and pyrazolines derivatives.

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20

B. jadhav, S., R. A. shastri, K. V. gaikwad, and S. V. gaikwad. "Synthesis and Antimicrobial Studies of Some Novel Pyrazoline and Isoxazoline Derivatives." E-Journal of Chemistry 6, s1 (2009): S183—S188. http://dx.doi.org/10.1155/2009/361564.

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A new series of 1H-3-(4’-substituted phenyl)-5-(6’’-methoxy napthaline)-2-pyrazolines (4a-e) and 1H-3-(4’-substituted phenyl)-5-(6’’-methoxynapthaline)-2-isoxazolines (5a-e) were synthesized by reacting 1-(4’-substituted phenyl)-3-(6’’-methoxynapthaline)-2-propene-1-one (3a-e) with hydrazine hydrate and hydroxylamine hydrochloride respectively. All these compounds were characterized by means of their IR,1H NMR, spectroscopic data and microanalysis. All the synthesized products were evaluated for their antimicrobial activity. All the compounds exhibited significant to moderate antimicrobial act

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21

A., H. SIDDIQUI, SATYANARAYANA Y., and SRINIVAS and K. RAJESHWAR M. "Synthesis of Azasteroids with Pyrazoline and lsoxazoline Rings." Journal of Indian Chemical Society Vol. 69, Dec 1992 (1992): 846–48. https://doi.org/10.5281/zenodo.6032514.

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Department of Chemistry, Nizam College, Hyderabad-500 001 <em>Manuscript received 17 June 1992, accepted 21 September 1992</em> 17-Oxo-5-androsten-3<em>β-</em>YI acetate (1) on reaction with dimethyl oxalate afforded the glyoxalate, 16-carbomethoxycarbonyl17-oxo-5-androsten-3<em>β</em>-YI acetate (2) which on reaction with hydrazine hydrate, phenylhydrazine and hydroxyl amine hydrochloride gave the corresponding 3<em>β</em>-acetoxy-5'-carbomethoxyandrost-5-en [17,16-c] pyrazole (3), 3<em>β</em>-acetoxy-5'-carbomethoxy-1'-phenylandrost-5-en [1

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22

Idrees Ibrahim, Hala. "Synthesis of some new heterocyclic compounds by High- Speed,Microwaveirradiation and pharmacological evaluation." Tikrit Journal of Pharmaceutical Sciences 9, no. 2 (2023): 338–55. http://dx.doi.org/10.25130/tjphs.2013.9.2.17.338.355.

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A series of substituted chalcones (1-4) were synthesized and used to prepare some new membered heterocyclic compounds (Pyrimidinones)(5-12) by their condensation with urea and thiourea, and four membered heterocyclic compounds (Pyrazolines) (13-16) by their condensation with 2,4-dinitrophenyl hydrazine also, four membered heterocyclic compounds (isoxazolines) (17-20) by their condensation with aminohydroxide hydrochloride. All reactions were carried out under microwave irradiation (MW1) is described. The synthesized compounds are characterized by FTIR and C.H.N analysis. We also study the biol

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23

Al-Bogami, Abdullah S., Hamad Z. Alkhathlan, and Tamer S. Saleh. "Microwave Enhanced Green Synthesis of 2-Pyrazolines, Isoxazolines and Cyclohexenones." Asian Journal of Chemistry 25, no. 11 (2013): 6427–33. http://dx.doi.org/10.14233/ajchem.2013.15070.

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24

A., H. SIDDIQUI, SATYANARAYANA Y., SRINIVAS M., and RAJESHWAR K. "Synthesis of Azasteroids with Pyrazoline and lsoxazoline Rings." Journal of Indian Chemical Society Vol. 69, Dec 1992 (1992): 846–48. https://doi.org/10.5281/zenodo.6117378.

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Department of Chemistry, Nizam College, Hyderabad-500 001  <em>Manuscript received 17 June 1992, accepted 21 September 1992</em> 17-0xo-5-androsten-3<em>β</em>-yl acetate (1) on reaction with dimethyl oxalate afforded the glyoxalate, 16-carbomethoxycarbonyl-17-oxo-5-androsten-3<em>β-</em>yl acetate (2) which on reaction with hydrazine hydrate, phenylhydrazine and hydroxyl amine hydrochloride gave the corresponding 3<em>β</em>-acetoxy-5'-carbomethoxyandrost-5-en [17,16-<em>c</em>] pyrazole (3), 3<em>β</em>-acetoxy-5'-carbomethoxy-1'-

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25

S., K. Sahu, Afzal Azam Md., Benerjee M., et al. "Synthesis and biological evaluation of 3-(phthalimidomethyl)-4- (5-substituted isoxazoline and pyrazoline) substituted benzanilides." Journal of Indian Chemical Society Vol. 84, Oct 2007 (2007): 1011–15. https://doi.org/10.5281/zenodo.5827044.

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University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar-75 I 005, Orissa, India <em>E-mail</em>: tutu_kh@yahoo.com Department of Pharmaceutical Chemistry, 1. S. S. College of Pharmacy, Ootacamund-643 00 I, Tamilnadu, India Department of Chemistry, Berhampur University, Berhampur-760 00 I, Orissa, India <em>Manuscript received 4 May 2006, revised 24 May 2007, accepted 20 July 2007</em> 3-Phthalimidomethylbcnzoic acids 2 were prepared by treating <em>N</em>-hydroxymethylphthalimidc 1 with substituted benzoic acids. The corresponding acid chlorides 3 were

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26

M., D. ANKHIWALA. "Studies in Spiro-heterocycles. Synthesis and Antimicrobial Activities of some New Spiro(indolin-3,5' -pyrazolin)-1 '·phenyl-2-ones and Spiro(indolin-3,5'-isoxazolin)-2-ones·." Journal of Indian Chemical Society Vol. 67, May 1990 (1990): 432–34. https://doi.org/10.5281/zenodo.6279807.

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Department of Chemistry, R. R. Mehta College of Science Palanpur-385 002 Manuscript received 28 April 1989. revised 6 September 1989 accepted 4 January 1990 Studies in Spiro-heterocycles. Synthesis and Antimicrobial Activities of some New Spiro(indolin-3,5' -pyrazolin)-1 '·phenyl-2-ones and Spiro(indolin-3,5'-isoxazolin)-2-ones· 

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27

Luo, Zhigang, Zhengyong Liu, Guanglong Zhang, Jiexin Ye та Zhuohong Yang. "Synthesis and Phototoxic Activity of Isoxazole and Pyrazoline Derivatives Containingα-Terthiophene". Chinese Journal of Organic Chemistry 34, № 2 (2014): 392. http://dx.doi.org/10.6023/cjoc201308008.

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28

S., K. Sahu, Afzal Azam Md., Banerjee M., Choudhury P., Sutradhar S., and K. Misro P. "Synthesis and biological evaluation of 3-(phthalimidoethyl)-4-(5-substituted isoxazoline and pyrazoline) substituted benzanilides." Journal of Indian Chemical Society Vol. 86, May 2009 (2009): 498–503. https://doi.org/10.5281/zenodo.5810178.

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University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar-751 005, Orissa, India J. S. S. College of Pharmacy, Ootacamund-643 001, Tamilnadu, India Department of Chemistry, Berhampur University, Berhampur-760 007. Orissa, India <em>E-mail</em> : tutu_ kh@yahoo. com <em>Manuscript received 16 March 2008, revised 15 October 2008, accepted 11 February 2009</em> 3-Phthalimidoethyl benzoic acids 2a-g were prepared by treating <em>N</em>-hydroxy-ethylphthalimide 1 with substituted benzoic acids. The corresponding acid chlorides 3a-g were condensed with 4-aminoacetophenone in th

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29

Zhang, Tao, Mengya Dong, Jianjiang Zhao, Xiaofang Zhang, and Xiangdong Mei. "Synthesis and antifungal activity of novel pyrazolines and isoxazolines derived from cuminaldehyde." Journal of Pesticide Science 44, no. 3 (2019): 181–85. http://dx.doi.org/10.1584/jpestics.d19-028.

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30

Wei, Qiang, Jia-Rong Chen, Xiao-Qiang Hu, Xiao-Chen Yang, Bin Lu, and Wen-Jing Xiao. "Photocatalytic Radical Trifluoromethylation/Cyclization Cascade: Synthesis of CF3-Containing Pyrazolines and Isoxazolines." Organic Letters 17, no. 18 (2015): 4464–67. http://dx.doi.org/10.1021/acs.orglett.5b02118.

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31

Abdula, Ahmed Mutanabbi, Ghazwan Ali Salman, and Hamid H. Mohammed. "Comparative Study on Conventional and Ultrasound Irradiation Promoted Synthesis of 2,3-Disubstitutedquinoxaline Derivatives." Al-Mustansiriyah Journal of Science 28, no. 3 (2018): 141. http://dx.doi.org/10.23851/mjs.v28i3.207.

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A series of ten chalcone-substituted quinoxalines (4a-e), (3a-e) starting from 1-(phenylquinoxalin-2-yl)ethanone and 1-(3-methylquinoxalin-2-yl)ethanone have been synthesized using conventional heating and ultrasound-assisted methods. Furthermore, novel of five quinoxaline derivatives including pyrazoline, isoxazole, pyrimidin-2-one, N-acylpyrazoline and pyridin-2-one moieties were also prepared from the reaction of chalcone compound 4a with different cyclization reagents using the same strategy. The structures of all synthesized compounds were established on the basis of FT-IR, 1H-NMR and 13C

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32

Kanar Muthanna Alawad, Monther Faisal Mahdi, and Ayad M.R. Raauf. "Molecular Docking study, and In vitro Evaluation of Antitumor Activity of Some New Isoxazoline and Pyrazoline Derivatives of Nabumetone against breast cancer cell line (MCF-7)." Al Mustansiriyah Journal of Pharmaceutical Sciences 22, no. 3 (2022): 24–34. http://dx.doi.org/10.32947/ajps.v22i3.886.

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A variety of new pyrazolines, isoxazolines, and amide derivatives were designed, synthesized, and tested in vitro for their cytotoxic potential against the breast cancer cell line MCF-7. Nabumetone is a prodrug that is used as non-steroidal anti-inflammatory drug  (NSAID). Before synthesis, the Molecular docking program (GOLD suite v. 5.7.1) was used to evaluate the selectivity for ER-α receptor, which demonstrated good agreement with the in vitro findings. Specifically, compounds 1e and 2e that target the ER- α receptor had the greatest PLP fitness values of (75.61 and 73.36), res

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33

Bhosle, Manisha R., Jyotirling R. Mali, Umesh R. Pratap, and Ramrao A. Mane. "An Efficient Synthesis of New Pyrazolines and Isoxazolines Bearing Thiazolyl and Etheral Pharmacophores." Bulletin of the Korean Chemical Society 33, no. 6 (2012): 2012–16. http://dx.doi.org/10.5012/bkcs.2012.33.6.2012.

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34

Radhika, T., A. Vijay, B. V. Harinadha, and B. Madhavareddy. "Design, Synthesis, Molecular Docking Studies, and Biological Evaluation of Pyrazoline Incorporated Isoxazole Derivatives." Russian Journal of Bioorganic Chemistry 46, no. 3 (2020): 429–37. http://dx.doi.org/10.1134/s1068162020030152.

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35

Chen, Yu, Yulin Lam, and Yee-Hing Lai. "Solid-Phase Synthesis of Pyrazolines and Isoxazolines with Sodium Benzenesulfinate as a Traceless Linker." Organic Letters 5, no. 7 (2003): 1067–69. http://dx.doi.org/10.1021/ol0340888.

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36

Wei, Qiang, Jia-Rong Chen, Xiao-Qiang Hu, Xiao-Chen Yang, Bin Lu, and Wen-Jing Xiao. "ChemInform Abstract: Photocatalytic Radical Trifluoromethylation/Cyclization Cascade: Synthesis of CF3-Containing Pyrazolines and Isoxazolines." ChemInform 47, no. 5 (2016): no. http://dx.doi.org/10.1002/chin.201605144.

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37

Lebed, Pavlo S., Johan Fenneteau, Yong Wu, Janine Cossy, and Pavel K. Mykhailiuk. "Synthesis of N -Nitroso CHF2 -Pyrazolines and Their Transformation into CHF2 -Isoxazolines and -Pyrazoles." European Journal of Organic Chemistry 2017, no. 41 (2017): 6114–20. http://dx.doi.org/10.1002/ejoc.201700803.

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38

Wu, Xiao-Bao, Quan Gao, Jun-Jie Fan, et al. "Anionic Chiral Co(III) Complexes Mediated Asymmetric Halocyclization─Synthesis of 5-Halomethyl Pyrazolines and Isoxazolines." Organic Letters 23, no. 23 (2021): 9134–39. http://dx.doi.org/10.1021/acs.orglett.1c03456.

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39

Nagy, Edith, and Salvatore D. Lepore. "Alkyne Cycloadditions Mediated by Tetrabutylammonium Fluoride: A Unified and Diversifiable Route to Isoxazolines and Pyrazolines." Organic Letters 19, no. 14 (2017): 3695–98. http://dx.doi.org/10.1021/acs.orglett.7b01401.

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40

Bhosle, Manisha R., Amarsinh R. Deshmukh, Savita Pal, Arvind K. Srivastava, and Ramrao A. Mane. "Synthesis of new thiazolylmethoxyphenyl pyrimidines and antihyperglycemic evaluation of the pyrimidines, analogues isoxazolines and pyrazolines." Bioorganic & Medicinal Chemistry Letters 25, no. 11 (2015): 2442–46. http://dx.doi.org/10.1016/j.bmcl.2015.03.068.

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41

Badadhe, P. V., N. M. Chavan, P. G. Mandhane, R. S. Joshi, D. R. Nagargoje, and C. H. Gill. "ChemInform Abstract: Synthesis and Characterization of Some Novel Isoxazolines and Pyrazolines as Potent Antimicrobial Agents." ChemInform 42, no. 40 (2011): no. http://dx.doi.org/10.1002/chin.201140124.

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42

Fu, Xiaolan, Peng Huang, Guangyuan Zhou, Yinqiao Hu, and Dewen Dong. "Divergent synthesis of fully substituted isoxazoles and spiro-fused pyrazolin-5-ones from cyclopropyl oximes." Tetrahedron 67, no. 34 (2011): 6347–51. http://dx.doi.org/10.1016/j.tet.2011.05.136.

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43

Zelenin, K. N., M. Yu Malov, A. Yu Ershov, et al. "Synthesis and structure of 5-hydrazino- and 5-hydroxyamino-3-aryl-2-pyrazolines and-2-isoxazolines." Chemistry of Heterocyclic Compounds 25, no. 7 (1989): 772–79. http://dx.doi.org/10.1007/bf00472749.

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44

ERSHOV, A. YU. "ChemInform Abstract: Reaction of 5-Amino-2-isoxazolines and 5-Amino-2-pyrazolines with Phenyl Isothiocyanate." ChemInform 27, no. 27 (2010): no. http://dx.doi.org/10.1002/chin.199627153.

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45

Bano, Sameena, Mohammad Sarwar Alam, Kalim Javed, Mridu Dudeja, Ayan Kumar Das, and Abhijeet Dhulap. "Synthesis, biological evaluation and molecular docking of some substituted pyrazolines and isoxazolines as potential antimicrobial agents." European Journal of Medicinal Chemistry 95 (May 2015): 96–103. http://dx.doi.org/10.1016/j.ejmech.2015.03.031.

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46

Fu, Xiaolan, Peng Huang, Guangyuan Zhou, Yinqiao Hu, and Dewen Dong. "ChemInform Abstract: Divergent Synthesis of Fully Substituted Isoxazoles and Spirofused Pyrazolin-5-ones from Cyclopropyl Oximes." ChemInform 42, no. 52 (2011): no. http://dx.doi.org/10.1002/chin.201152126.

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47

Gil-Ordóñez, Marta, Camille Aubry, Cristopher Niño, Alicia Maestro, and José M. Andrés. "Squaramide-Catalyzed Asymmetric Mannich Reaction between 1,3-Dicarbonyl Compounds and Pyrazolinone Ketimines: A Pathway to Enantioenriched 4-Pyrazolyl- and 4-Isoxazolyl-4-aminopyrazolone Derivatives." Molecules 27, no. 20 (2022): 6983. http://dx.doi.org/10.3390/molecules27206983.

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A series of N-Boc ketimines derived from pyrazolin-5-ones have been used as electrophiles in enantioselective Mannich reactions with different 1,3-dicarbonyl compounds. This method provides a direct pathway to access the 4-amino-5-pyrazolone derivatives bearing a quaternary substituted stereocenter and containing two privileged structure motifs, the β-diketone and pyrazolinone substructures. The adducts were obtained in excellent yields (up to 90%) and enantioselectivities (up to 94:6 er) by employing a very low loading of 2 mol% of a quinine-derived bifunctional squaramide as an organocatalys

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48

Hockstedler, Amy N., Beatrice A. Edjah, Saajid Z. Azhar, et al. "13C NMR spectroscopy of heterocycles: 1-phenyl-3-aryl/t-butyl-5-arylpyrazoles." Heterocyclic Communications 23, no. 2 (2017): 125–31. http://dx.doi.org/10.1515/hc-2017-0034.

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AbstractA series of chalcones 1–12 were converted to pyrazolines (1Pi–12Pi) by reaction with phenylhydrazine followed by DDQ oxidation to produce the corresponding pyrazoles (1Pz–12Pz). Three 1-phenyl-3-t-butyl-5-arylpyrazoles (13Pz–15Pz) were synthesized using an analogous approach. Molecular modeling studies predicted the 5-aryl group of the pyrazoles for both series to have a torsion angle of 52°–54° whereas the 1-phenyl group was predicted to have 35°–37° torsion angles. The 3-aryl group was predicted to be essentially coplanar (−3°) with the pyrazole system in the first series. 13C NMR da

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Azarifar, Davood, Kaveh Khosravi, and Rahman Ali Veisi. "An efficient oxidation of 2-pyrazolines and isoxazolines by bis-bromine-1,4-diazabicyclo[2.2.2]octane complex (DABCO-Br2)." Arkivoc 2010, no. 9 (2010): 178–84. http://dx.doi.org/10.3998/ark.5550190.0011.917.

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Dofe, Vidya S., Aniket P. Sarkate, Shailee V. Tiwari, et al. "Ultrasound assisted synthesis of tetrazole based pyrazolines and isoxazolines as potent anticancer agents via inhibition of tubulin polymerization." Bioorganic & Medicinal Chemistry Letters 30, no. 22 (2020): 127592. http://dx.doi.org/10.1016/j.bmcl.2020.127592.

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