Relevant bibliographies by topics / Pyridazines

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Pyridazines'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Pyridazines"

1

Sepsey Für, Csilla Sepsey, Gergő Riszter, Áron SzigetvárI, et al. "Novel Ring Systems: Spiro[Cycloalkane] Derivatives of Triazolo- and Tetrazolo-Pyridazines." Molecules 26, no. 8 (2021): 2140. http://dx.doi.org/10.3390/molecules26082140.

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In orderto synthesize new pyridazine derivatives anellated with different nitrogen heterocyclic moieties, spiro[cycloalkane]pyridazinones were transformed into the corresponding thioxo derivatives via a reaction with phosphorus pentasulfide. The reaction of the formed 2,3-diazaspiro[5.5] undec-3-ene-1-thiones with hydrazine provided the corresponding 1-hydrazono-2,3-diazaspiro[5.5] undec-3-ene, whose diazotization led to the desired spiro[cyclohexane-1,8′-tetrazolo[1,5-b]pyridazines. The reaction of dihydropyridazinethiones with benzhydrazide afforded the corresponding 7H-spiro[[1,2,4]triazolo
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M., Sumakanth, V. Malla Reddy, V. S. H. Krishnan, and B. S. Sastry. "Synthesis of Some New Imidazo[1,2-b] Pyridazines." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 1 (2009): 471–76. http://dx.doi.org/10.37285/ijpsn.2009.2.1.14.

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Several 2,6-diaryl-imidazo[1,2-b]pyridazines (5 & 7) were prepared from 3-amino-6-aryl-pyridazines (3) which in turn were obtained from the corresponding 6-aryl-pyridazine-3(2H)-ones(1) via., 6-aryl-pyridazin-3(2H)-thiones (2) as intermediates, by a reaction with an appropriate a-halocarbonyl compounds (4) or a-haloacyl carbamates (6) in a suitable solvent at reflux temperature. The resulted products were characterized by their physical, analytical and spectral data.
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Barlin, GB, LP Davies, PW Harrison, NW Jacobsen, and AC Willis. "Imidazo[1,2-b]Pyridazines. XVI. Synthesis and Central Nervous System Activities of Some 6-(Chloro, Alkylthio, Phenylthio, Benzylthio or Pyridinylmethylthio)-3-(unsubstituted, benzamidomethyl or methoxy)-2-(styryl or benzoyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 47, no. 11 (1994): 1989. http://dx.doi.org/10.1071/ch9941989.

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Some 6-( chloro, alkylthio, phenylthio, benzylthio or pyridinylmethylthio )-3-( unsubstituted , benzamidomethyl or methoxy )-2-styrylimidazo[1,2-b] pyridazines and 6-chloro-3-( unsubstituted and benzamidomethyl )-2-benzoylimidazo[1,2-b] pyridazines have been prepared and tested for their ability to displace [3H]diazepam from rat brain plasma membranes. The structures of 6-chloro-2-benzoyl[and 6-fluoro-2-(4′-tolyl)] imidazo [1,2-b] pyridazine have been confirmed by X-ray analyses. The reactions of 6-methylthio(and 6-phenylthio)pyridazin-3-amines with 3-bromo-1-phenylpropane-1,2-dione also have
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Mohammad, Asif, Abida, and Tauquir Alam Md. "Diverse chemical and biological potentials of various pyridazine and pyridazinone derivatives." Chemistry International 5, no. 3 (2019): 206–31. https://doi.org/10.5281/zenodo.2525555.

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A series of heterocyclic compounds incorporating pyridazine moiety were for diverse biological activities. Pyridazines and pyridazinones derivatives showed wide spectrum of biological activities such as vasodialator, cardiotonic, anticonvulsant, antihypertensive, antimicrobial, anti-inflammatory, analgesic, anti-feedant, herbicidal,  and various other biological, agrochemical and industrial chemical activities. The results illustrated that the synthesized pyridazine/pyridazine compounds have diverse and significant biological activities. Mechanistic insights into the biological properties
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Barlin, GB. "Imidazo[1,2-B]Pyridazines. I. Some 3-Alkoxy-6-Halogeno-2-Phenyl-(and 4′-Substituted Phenyl)Imidazo[1,2-B]Pyridazines and 3-Methoxy-2,6-Diphenylimidazo[1,2-B]Pyridazine." Australian Journal of Chemistry 39, no. 11 (1986): 1803. http://dx.doi.org/10.1071/ch9861803.

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A series of 3-alkoxy-6-halogeno-2-phenyl(and 4′-substituted phenyl) imidazo [1,2-b] pyridazines (1) and 3-methoxy-2,6- diphenylimidazo [1,2-b] pyridazine have been prepared from the relevant pyridazin-3-amines and arylglyoxals, followed by O- alkylation of the corresponding imidazo [1,2-b]pyridazin-3(5H)-ones with diazoalkanes. 6- Chloro-3-methoxy-2-phenylimidazo[2,1-a] phthal-azine was prepared similarly.
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Barlin, GB, LP Davies, SJ Ireland, and JK Zhang. "Imidazo[1,2-b]pyridazines. XIV. Syntheses and Central Nervous System Activities of Some 6-(Methoxy-, dimethoxy-, methylenedioxy-, chloro- and fluoro-)-3-alkoxy-2-phenyl(and substituted phenyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 46, no. 3 (1993): 353. http://dx.doi.org/10.1071/ch9930353.

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Syntheses are reported for 28 new 3-alkoxy-6-(3′-methoxy-,3′,4′-dimethoxy, 3′,4′-methylene-dioxy-, 2′- and 4′-chloro- and 4′-fluoro-benzylamino)-2-phenyl(and substituted phenyl) imidazo -[1,2-b] pyridazines from the corresponding 6-substituted pyridazin-3-amine 2-oxides with α- bromoacetophenones, followed by alkylation of the intermediate 3-hydroxyimidazo[1,2-b] pyridazines. In tests of the ability of these compounds to displace [3H]diazepam from rat brain membrane, 3-(2′-ethoxyethoxy)-6(3′-methoxybenzylamino)-2-phenyl- and 6(3′,4′-methylenedioxybenzylamino )-2-(3″,4″-methylenedioxyphenyl)-3-
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Kazimierczuk, Zygmunt, Jarosław Kamiński, and Flavio Meggio. "Studies on Improved Synthesis of 2'-Deoxyribonucleosides of Pyridazine Derivatives." Collection of Czechoslovak Chemical Communications 71, no. 6 (2006): 889–98. http://dx.doi.org/10.1135/cccc20060889.

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A number of 2'-deoxyribonucleosides of halogenated pyridazine derivatives were prepared by glycosylation of their respective potassium or DBU salts in acetone. The reaction yielded predominatly β-anomers that could be purified by simple crystallization or column chromatography. Of the studied pyridazines and deoxynucleosides, only 4-bromo-6-chloropyridazin-3-one and 6-chloro-2-(2'-deoxyribofuranosyl)pyridazin-3-one showed modest inhibition of CK2 kinase.
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Schmitt, Martine, Jean-Jacques Bourguignon, Gordon B. Barlin, and Les P. Davies. "Imidazo[1,2-b]pyridazines. XXIV Syntheses of Some 3-(Variously Substituted) Imidazo[1,2-b] pyridazines, 6-Substituted 2-Benzoyl- imidazo[1,2-b]pyridazines and Pyrimido[1,2-b]pyridazin- 5-ium-3-olates and their Interaction with Central and Mitochondrial Benzodiazepine Receptors." Australian Journal of Chemistry 50, no. 8 (1997): 779. http://dx.doi.org/10.1071/c97030.

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The syntheses of some ethyl 2-{2′-aryl-6′-(chloro, iodo and methoxy)imidazo[1,2-b]pyridazin-3′-yl}-2-(acetoxy, acylamino, hydroxy and methoxy)acetates, 6-methyl-2-(p-tolyl)- and 6-chloro-2-(4′-chlorophenyl)-3-trimethylammoniomethylimidazo[1,2-b]pyridazine iodides (and reactions thereof), 2-benzoyl 6-substituted imidazo[1,2-b]pyridazines and 7-(methoxy, chloro and phenylthio)-2-phenylpyrimido-[1,2-b]pyridazin-5-ium-3-olates are reported. The ability of these compounds to displace [3H]diazepam from rat forebrain membrane [central benzodiazepine receptor (BZR)] and rat kidney membrane [mitochondr
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Deeb, Ali, Besher Bayoumy, Fathy Yasine, and Rida Fikry. "Pyridazine Derivatives and Related Compounds, Part 4. Pyrrolo[2,3-c]pyridazines and Furo[2,3-c]pyndazines, Synthesis and Some Reactions." Zeitschrift für Naturforschung B 47, no. 3 (1992): 418–23. http://dx.doi.org/10.1515/znb-1992-0320.

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Ethyl 5-amino-3,4-diphenyl-7H-pyrrolo[2,3-c]pyridazine-6-carboxylate (1), ethyl 5-aminofuro[ 2,3-c]pyridazine-6-carboxylate (2) and 5-aminofuro[2,3-c]pyridazine-6-carboxamide (3), are obtained from 4-cyano-5,6-diphenyl-3(2H)-pyridazinone. 5-Acetamido and 5-chloroacetamido derivatives prepared from 1, undergo cyclization on heating to form 2-substituted pyridazino[4',3':4,5]pyrrolo[3,2-d]oxazin-4(5H)-one (5a, b). The reaction of 1 and 2 with hydrazine gave 6-carbohydrazide derivatives (7 a, b). Compound 3 undergoes condensation with acetyl chloride, chloroacetyl chloride, benzoyl chloride, form
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Barlin, GB, LP Davies, SJ Ireland, and JK Zhang. "Imidazo[1,2-b]pyridazines. XI. Syntheses and Central Nervous System Activities of Some 6-(N-Benzyl-N-methylamino)-3-methoxy-2-phenyl(and substituted phenyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 45, no. 4 (1992): 751. http://dx.doi.org/10.1071/ch9920751.

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Syntheses are reported for 196-(N-benzyl-N-methylamino )-3-methoxy-2-phenyl(and substituted phenyl or pyridinyl ) imidazo [1,2-b] pyridazines from 6-(N-benzyl-N-methylamino)pyridazin-3- amine 2-oxide. The ability of each of these compounds to displace [3H]diazepam from rat brain membrane preparations was measured and the IC50 values (or percentage displacements) are reported and discussed. 6-(N-Benzyl-N-methylamino )-3-methoxy-2-phenylimido[1,2-b]pyridine was about half as active as its 6-bemylamino analogue, and the most active compound was 6-(N-benzyl-N-methylamino )-2-(2'-fluorophenyl)-3-me
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Dissertations / Theses on the topic "Pyridazines"

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Schaack, Claudine. "Amino-3 pyridazines présentant un intérêt thérapeutique." Strasbourg 1, 1985. http://www.theses.fr/1985STR10475.

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DESMARTIN, VINCENT. "Synthese et activite cholinergique d'imidazo(1,2-b)pyridazines." Strasbourg 1, 1994. http://www.theses.fr/1994STR15050.

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Vaccarella, Graziano. "Synthesis and activity of pyridazine analogues of the excitatory neurotransmitter, glutamic acid." Thesis, The University of Sydney, 1998. https://hdl.handle.net/2123/27573.

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The synthesis and pharmacological assessment of novel pyridazine analogues of the neurotransmitter glutamic acid was the focus of this investigation. The project aimed to prepare agents for selective activation of the AMPA receptor subtype. The proposition investigated was that the six-membered pyridazine ring with an acidic hydroxyl group would provide a versatile carboxylic acid bioisostere and these compounds would be amenable to further derivatisation.
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Bécart-Verhaeghe, Françoise. "Contribution à l'étude du mécanisme moléculaire d'action de la minaprine synthèse d'amino-3 pyridazines fonctionnalisées en 4 et d'imidazo [1,2-b] pyridazines /." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb376027254.

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Heard, Peter John. "Dynamic NMR studies on some stereochemically non-rigid transition metal complexes of azines." Thesis, University of Exeter, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385695.

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Cannon, Benjamin Tyree. "Thiophene and Derivatives for Use in Pyridazines and Thiapentalenes." TopSCHOLAR®, 2015. http://digitalcommons.wku.edu/theses/1476.

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This thesis introduces the idea of Band Theory and how it can be used to describe a solid-state materials ability to carry an electrical charge. Next, this thesis defines what makes a material a conductor, semiconductor, or insulator. Semiconductors are attracting interest in chemistry, as well as in the manufacturing of consumer electronics, because of their ability to carry a charge, without the risk of short-circuiting like traditional conductors.1,4 Organic semiconductors, which behave differently than traditional semiconductors, are of particular interest because they offer mechanical fle
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Becart-Verhaeghe, Françoise. "Contribution à l'étude du mecanisme moleculaire d'action de la minaprine : synthese d'amino-3 pyridazines fonctionnalisees en position 4 et d'imidazo-(1,2-b) pyridazines." Strasbourg 1, 1987. http://www.theses.fr/1987STR13235.

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Ezzili, Cyrine. "Voies d'accès aux imidazo[1,2-b]pyridazines par synthèse parallèle." Paris 11, 2005. http://www.theses.fr/2005PA112371.

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Mon projet de thèse porte sur la découverte de nouvelles voies d’accès aux imidazo[1,2-b]pyridazines. Ce travail a été réalisé dans le cadre d’une convention de type CIFRE entre les laboratoires Fournier et le CEA. Le but qui m’a été fixé limite mon projet à l’utilisation de voies de synthèse adaptées à la chimie combinatoire permettant de produire une chimiothèque de quelques centaines de composés. Nous avons étudié trois stratégies de synthèse. La première stratégie se base sur la cyclisation de Tschitschibabin. Cette réaction consiste en la condensation d’une aminopyridazine et d’un dérivé
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MORIN, ISABELLE. "3-aryl as-triazines : bioisosterie avec les 6-aryl pyridazines." Université Louis Pasteur (Strasbourg) (1971-2008), 1991. http://www.theses.fr/1991STR13021.

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Un examen comparatif de bioisosteres potentiels de derives pyridaziniques (pyrazines, pyrimidines, 1,3,4-thiadiazoles, et 1,2,4-triazines) a ete realise. Les structures etablies par diffraction aux rayons x suivies de calculs semi-empiriques ont mis en evidence l'importance du moment dipolaire comme critere de differenciation entre ces differents systemes heterocycliques. Le systeme as-triazinique, predit comme devant etre bioequivalent des pyridazines a ete plus particulierement etudie. Sur le plan chimique, des ameliorations ont ete apportees a leur synthese au depart de derives d'hippurate
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Merlier, Josiane. "Synthèse et étude pharmacologique d'une série d'amino-3 pyridazines anticonvulsivantes." Strasbourg 1, 1988. http://www.theses.fr/1988STR13224.

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Books on the topic "Pyridazines"

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Mayer, Michael. Farbe und Konstitution bei H-Chelaten der Pyrazinreihe: Präparative und spektroskopische Untersuchungen. Hartung-Gorre, 1985.

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Güven, Alâettin. Potentially tautomeric pyridazino (4,5-b) indolones. University of East Anglia, 1992.

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A, Graf Josef. Struktur-Funktionsbeziehungen zwischen Lipidmatrix und Pigment-Protein-Komplexen in Thylakoidmembranen: Physiologische und fluoreszenzspektroskopische Untersuchungen zur Wirkung von Pyridazinonen, Cytokininen und Cerulenin bei Petunia hybrida. [Biologisches Institut der Universität Stuttgart], 1987.

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Taylor, Edward C., Peter Wipf, and Desmond J. Brown. Supplement 1, Pyridazines. Wiley-Interscience, 1999.

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Castle, Raymond N. Pyridazines. Wiley & Sons, Incorporated, John, 2009.

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The pyridazines. Wiley, 2000.

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Tétényi, Péter. Polymers and Pyridazines. Jenny Stanford Publishing, 2019. http://dx.doi.org/10.1201/9780429296468.

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Tétényi, Péter. Polymers and Pyridazines. Jenny Stanford Publishing, 2019.

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Tétényi, Péter. Polymers and Pyridazines. Jenny Stanford Publishing, 2019.

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Tétényi, Péter. Polymers and Pyridazines. Jenny Stanford Publishing, 2019.

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Book chapters on the topic "Pyridazines"

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Li, Jie Jack, and Minmin Yang. "Pyridazines." In Drug Discovery with Privileged Building Blocks. CRC Press, 2021. http://dx.doi.org/10.1201/9781003190806-22.

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Mason, James W., and Duane L. Aldous. "The Pyridazinones, Alkoxy- and Aryloxy-Pyridazines, and Related Compounds." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186985.ch2.

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Lenhert, Anne G., and Raymond N. Castle. "Physical Properties of Pyridazines." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186985.ch1.

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Tiŝler, M., and B. Stanovnik. "Sulfur Compounds of Pyridazines." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186985.ch9.

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Shaner, Dale L., Laurine M. Speltz, and Stephen S. Szucs. "Synthesis and Herbicidal Activity of Pyridazines Based on 3-Chloro-4-methyl-6-[m-(trifluoromethyl)phenyl]pyridazine." In ACS Symposium Series. American Chemical Society, 1987. http://dx.doi.org/10.1021/bk-1987-0355.ch003.

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Itai, Takanobu. "PyridazineN-Oxides." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186985.ch8.

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South, Michael S., Terri L. Jakuboski, Michael J. Miller, et al. "Synthesis and Structure-Activity/Selectivity Studies of Novel Heteroaryloxy, Aryloxy, and Aryl Pyridazines as Bleaching Herbicides." In ACS Symposium Series. American Chemical Society, 1998. http://dx.doi.org/10.1021/bk-1998-0686.ch012.

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Demaison, J. "410 C4H4N2 Pyridazine." In Asymmetric Top Molecules. Part 2. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-10400-8_158.

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Winkelmann, Jochen. "Self-diffusion coefficient of pyridazine." In Diffusion in Gases, Liquids and Electrolytes. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-540-73735-3_102.

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Lenhert, Anne G., and Raymond N. Castle. "Pyridazine Aldehydes, Ketones, and Alcohols." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186985.ch4.

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Conference papers on the topic "Pyridazines"

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Mátyus, Péter, Olivér Éliás, Lázló Károlyházy, Géza Stájer, Veronika Harmath, and Orsolya Barabás. "Ring Closure Reactions of 4-Chloro-5-hydroxyalkylamino-6-nitro-3(2H)- pyridazinones: Synthesis of Novel Pyridazino-Fused Ring Systems." In The 4th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01820.

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Wright, Austin. "Microwave Assisted Synthesis of Tri-substituted Pyridazine Exploration." In GS4 Student Scholars Symposium 2016. Georgia Southern University, 2016. https://doi.org/10.20429/gs4.2016.022.

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Salaheldin, Abdellatif, Lígia Rodrigues, and Ana Oliveira-Campos. "Heterocyclic Synthesis with Nitriles: Synthesis of Pyridazine and Pyridopyridazine Derivatives." In The 11th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2007. http://dx.doi.org/10.3390/ecsoc-11-01319.

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Titov, I. Yu, V. S. Stroylov, O. V. Stroganov, F. N. Novikov, I. V. Svitanko, and G. G. Chilov. "NOVEL 5,6,7,8-TETRAHYDROPYRAZINO[2,3-c]PYRIDAZINE3-CARBOXAMIDE DERIVATIVES AS DUAL ALK/NUAK1 INHIBITORS." In MedChem-Russia 2021. Издательство Волгоградского государственного медицинского университета, 2022. http://dx.doi.org/10.19163/medchemrussia2021-2022-25.

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Sudibyo, Usman, Muhamad Akrom, Harun Al Azies, et al. "QSPR model for predicting inhibition capacities of pyridazine-based corrosion inhibitors on mild steel." In THE 4TH MATERIALS RESEARCH SOCIETY OF INDONESIA (MRS-ID) MEETING. AIP Publishing, 2025. https://doi.org/10.1063/5.0240898.

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Salim, Muath Bani, and Reza Nekovei. "Designing of PCBM Derivative using Pyridazine Compound for More Efficient Bulk Heterojunction Organic Solar Cell." In 2021 IEEE 48th Photovoltaic Specialists Conference (PVSC). IEEE, 2021. http://dx.doi.org/10.1109/pvsc43889.2021.9519059.

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Floresta, Giuseppe, Letizia Crocetti, Chiara Zagni, and Agostino Cilibrizzi. "Pyridazin-3(2H)-one as New FABP4 Inhibitors Suggested by Molecular Growing Experiments." In ECMC 2022. MDPI, 2022. http://dx.doi.org/10.3390/ecmc2022-13445.

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Franich, Andjela, Ivana Vasić, Snežana Rajković, et al. "CYTOTOXICITY OF CATIONIC DINUCLEAR PLATINUM(II) COMPLEXES IN AN EXPERIMENTAL MODEL OF MOUSE COLON CANCER." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.293f.

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The series of nine dinuclear platinum(II) complexes, [{Pt(L)Cl}2(μ-X)]2+ (where L is two NH3 or bidentantly coordinated diamine ligand – ethylenediamine, en; (±)-1,2-propylenediamine, 1,2-pn; isobutylenediamine, ibn; trans-(±)-1,2-diaminocyclohexane, dach; 1,3-propylenediamine, 1,3-pd; 2,2- dimethyl-1,3-propylenediamine, 2,2-diMe-1,3-pd; (±)-1,3-pentanediamine,1,3-pnd, and X is a bridging pyrazine (pz) or pyridazine (pydz) ligand) have been synthesized and characterized. The antitumor potential of these complexes against CT26 cells were determined by in vitro and in vivo assays. A murine model
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Tarby, Christine M., Liqi He, Brian E. Fink, et al. "Abstract 5417: The identification of BMS-595, an orally active imidazo[1,2-b]pyridazine CK2 inhibitor with in vivo anti-tumor activity." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5417.

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Schnell, Barbara, and Thomas Kappe. "Rearrangement of Heterocycles via-2-oxoketenes: Synthesis and Rearrangement Reactions of Cross-Conjugated Mesomeric Pyridazino[2,3-a]pyrimidine." In The 4th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01844.

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