Relevant bibliographies by topics / Pyridazinone Synthesis

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Pyridazinone Synthesis'

Author: Grafiati
Published: 4 June 2021
Last updated: 2 February 2022

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Journal articles on the topic "Pyridazinone Synthesis"

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Deeb, Ali, Besher Bayoumy, Fathy Yasine, and Rida Fikry. "Pyridazine Derivatives and Related Compounds, Part 4. Pyrrolo[2,3-c]pyridazines and Furo[2,3-c]pyndazines, Synthesis and Some Reactions." Zeitschrift für Naturforschung B 47, no. 3 (March 1, 1992): 418–23. http://dx.doi.org/10.1515/znb-1992-0320.

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Ethyl 5-amino-3,4-diphenyl-7H-pyrrolo[2,3-c]pyridazine-6-carboxylate (1), ethyl 5-aminofuro[ 2,3-c]pyridazine-6-carboxylate (2) and 5-aminofuro[2,3-c]pyridazine-6-carboxamide (3), are obtained from 4-cyano-5,6-diphenyl-3(2H)-pyridazinone. 5-Acetamido and 5-chloroacetamido derivatives prepared from 1, undergo cyclization on heating to form 2-substituted pyridazino[4',3':4,5]pyrrolo[3,2-d]oxazin-4(5H)-one (5a, b). The reaction of 1 and 2 with hydrazine gave 6-carbohydrazide derivatives (7 a, b). Compound 3 undergoes condensation with acetyl chloride, chloroacetyl chloride, benzoyl chloride, formamide and carbon disulphide to furnish the corresponding pyrimido[4',5' :4,5]furo[2,3-c]pyridazin-4(3 H)-one derivatives. The reaction of 1 with o-aminophenol gave 3,4-diphenyl-11-oxo-10,11-dihydro-12H -pyridazino[ 4',3' :4,5]pyrrolo[3,2-b][1,5]benzoxazepine.
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Rimaz, Mehdi, Jabbar Khalafy, and Peyman Najafi Moghadam. "A Regioselective One-Pot, Three Component Synthesis of 6-Aryl-4-cyano-3(2H)-pyridazinones in Water." Australian Journal of Chemistry 63, no. 9 (2010): 1396. http://dx.doi.org/10.1071/ch09602.

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A series of 4-cyano-3(2H)-pyridazinones bearing different aryl substituents in the 6-position of the pyridazinone ring was synthesized regioselectively using a novel efficient one-pot three component reaction of alkyl 2-cyanoacetates with arylglyoxals in the presence of hydrazine hydrate at room temperature in water.
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Hovakimyan, S. A., A. V. Babakhanyan, V. S. Voskanyan, V. E. Karapetian, G. A. Panosyan, and S. T. Kocharian. "Synthesis of Pyridazinone Derivatives." Chemistry of Heterocyclic Compounds 40, no. 8 (August 2004): 1047–51. http://dx.doi.org/10.1023/b:cohc.0000046696.37815.62.

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Tao, Jing. "Synthesis of Aldehyde Hydrazones Containing Pyridazinone." Advanced Materials Research 361-363 (October 2011): 2008–11. http://dx.doi.org/10.4028/www.scientific.net/amr.361-363.2008.

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The reaction of 1,4,5,6-tetrahydro-6-pyridazinone-3-carboxylic acid hydrazides (1) and 1,6-dihydro-6-pyridazinone-3-carboxylic acid hydrazides (2) with four kind of substituted 3-formyl chromones (3a-3d) and five kind of 1-phenyl-3-aryl-4-formylpyrazoles (3e-3i) afforded the new compounds aldehyde hydrazones (4a-4i) and (5a-5i). Their structures were established by IR, 1H NMR and elemental analysis.
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Asif, Mohammad. "Some Conventional and Convenient Process for Functionalization of 6-Phenyl-4,5-Dihydropyridazinone Compounds." Asian Journal of Chemistry and Pharmaceutical Sciences 1, no. 1 (November 21, 2016): 41. http://dx.doi.org/10.18311/ajcps/2016/8375.

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The pyridazinone derivatives, particularly those bearing substituted different group or atom at a different position, have attracted considerable attention due to their characteristic pharmacological and other anticipated activities. These activities promoted the synthesis of a large number of substituted pyridazinone derivatives in order to explore the usefulness of this heterocyclic system. In the present review, various synthetic methods have been studied for the synthesis of substituted pyridazinone derivatives. The behaviour of the pyridazinone toward formaldehyde/piperidine, ethyl chloroacetate, chloroacetic acid, benzene sulfonyl chloride, bromine/acetic acid and aromatic aldehydes has also been studied. However, the reactions of the chloro derivative resulting from the reaction of pyridazinone with phosphorus oxychloride (POCl<sub>3</sub>). The behavior of chloropyridazine toward hydrazines, thiourea, sodium azide, anthranilic acid, aromatic amines and sulfa compounds have also been taken into consideration. Thethiopyridazinone derivativeswere prepared from the reaction of pyridazinone with phosphorus pentasulphide (P<sub>2</sub>S<sub>5</sub>). All the structures of were established on the based of spectroscopic data.<p> </p><p><strong> </strong></p>
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Wasfy, Ashraf A. F., Mohamed M. H. Arief, Mahassen S. Amine, Shafey G. Donia, and Aly A. Aly. "γ-Oxo Carboxylic Acids in Heterocyclic Synthesis, III. Synthesis of Biologically Active 4-Benzylamino-6-(5,5-dioxodibenzothiophen- 2-yl)-2,3,4,5-tetrahydropyridazin-3-ones." Zeitschrift für Naturforschung B 57, no. 6 (June 1, 2002): 668–76. http://dx.doi.org/10.1515/znb-2002-0613.

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α-Benzylamino-β-(5,5-dioxodibenzothiophen-2-carbonyl)propionic acid (1) has been synthesized by treating the corresponding β-aroylacrylic acid with benzylamine in dry benzene. On treatment with hydrazine hydrate the keto acid 1 furnishes the corresponding pyridazinone derivative 2. The behaviour of 2 towards carbon electrophiles, namely, ethyl chloroacetate, acrylonitrile, formaldehyde and secondary amines (under Mannich reaction conditions), aromatic aldehydes and carbon nucleophiles, namely, POCl3/PCl3 and P2S5 has been investigated. The 3-chloropyridazine derivative 13 reacts with hydrazine hydrate to give the 3-hydrazino derivative 14. On treatment with ethyl acetoacetate and/or acetylacetone the hydrazine 14 undergoes cyclization to afford pyrazolone derivative 16 and 3-(3,5-dimethylpyrazol- 1-yl)pyridazine derivative 17, respectively. On reaction with acetylhydrazine in boiling butanol and/or sodium azide in DMF the 3-chloropyridazine derivative 13 affords the triazolo[4,3-b]pyridazine 18 and the tetrazolo[1,5-b]pyridazine 19, respectively. The anti-microbial activity of the synthesized derivatives has been investigated.
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Samanta, Kartick Chandra, Mohd Asif, Pooja, Vikas Garg, Priyanka Sharma, and Ravinder Singh. "Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant Activity." E-Journal of Chemistry 8, no. 1 (2011): 245–51. http://dx.doi.org/10.1155/2011/873470.

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6-Phenyl(3᾽-imino-benzylidene)-2,3,4,5-tetrahydro pyridazin-3-one derivatives were synthesized from 6-(3᾽-aminophenyl)-2,3,4,5-tetrahydro pyridazin-3-one by reaction with different aldehydes. The respective pyridazinone was prepared by cyclization of appropriateβ-(aminophenyl) propionic acid with hydrazine hydrate. The pyridazinone derivatives were tested for anticonvulsant activity by MES (maximal electro shock) method and found that few of them have shown significant anticonvulsant activity.
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Ismail, Magda M. F., Dalia H. S. Soliman, Mona H. Abd Elmoniem, and Ghehad A. R. Abdel Jaleel. "Synthesis, Molecular Modeling of Novel Substituted Pyridazinones and their Vasorelaxant Activities." Medicinal Chemistry 17, no. 2 (December 30, 2020): 171–86. http://dx.doi.org/10.2174/1573406416666200327191100.

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Background: Hypertension, one of the most common cardiovascular diseases that can cause coronary disease, stroke, myocardial infarction, and sudden death, it is the major contributor to cardiac failure as well as renal insufficiency. Objectives: As there are many cardio-active pyridazinone-base derivatives in clinical use, therefore, we aimed to synthesize a new series of pyridazin-3-ones and evaluate their vasorelaxant activity. Methods: A new series of synthesized compounds were carried out first by the synthesis of 6- flouroarylpyridazinones by cyclization of 3-(4-flourobenzoyl) propionic acid with hydrazine hydrate or arylhydrazines to provide the corresponding pyridazinone derivatives 2a-d. Mannich reaction was performed using morpholine or piperidine formaldehyde to obtain compounds 3a,b. On the other hand, reaction of 2a with various chloroacetamide intermediates, in dimethylformamide and potassium carbonate as a catalyst, afforded the target compounds 5a-c. The aromatic acid hydrazide intermediates 6a-g were prepared in 50-90% yield, by reacting to the prepared esters with hydrazine hydrate under reflux in ethanol. The two compounds 8a,b were prepared via condensation of 7a,b with ethyl chloroacetate in dry acetone. Finally, the target 2,4,6-trisubstituted pyridazinones 9a-c derivatives were obtained by the reaction of 7a with the appropriate aromatic aldehyde or substituted acetophenones. The new compounds were then evaluated for their vasorelaxant properties using isolated thoracic rat aortic rings. In addition, a homology model was built and molecular modeling simulation of these compounds into the active sites of the newly created α1a-adrenoceptor model was performed in order to predict and rationalize their affinities toward this receptor. Results: Among these compounds; 5a was the most potent, it exhibited approximately two-times the activity of prazosin (IC50 = 0.250, 0.487 mmol, respectively) also, fourteen compounds were more potent than prazosin.
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TAKAYA, MASAHIRO. "Studies on Pyridazinone Derivatives. XI. Synthesis and Antifungal Activity of Amino Derivatives of Pyridazinone." YAKUGAKU ZASSHI 107, no. 10 (1987): 819–22. http://dx.doi.org/10.1248/yakushi1947.107.10_819.

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HUSAIN, ASIF, AFTAB AHMAD, ANIL BHANDARI, and VEERMA RAM. "SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF PYRIDAZINONE DERIVATIVES." Journal of the Chilean Chemical Society 56, no. 3 (2011): 778–80. http://dx.doi.org/10.4067/s0717-97072011000300013.

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Dissertations / Theses on the topic "Pyridazinone Synthesis"

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Greenwood, Jeremy R. (Jeremy Robert) 1971. "Pyridazinediones and amino acid receptors theoretical studies, design, synthesis and evaluation of novel analogues." [Sydney : J. Greenwood], 1999. http://www.pharmacol.usyd.edu.au/thesis.

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Title from title screen. Interactive three dimensional molecular data and multiple colour images. Text presented in Hypertext Markup Language (.htm); images in standard formats (.jpg, .gif); molecules presented mostly as Cambridge Protein Data Bank format (.pdb); some molecules presented in alternative X.Mol cartesian co-ordinates format (.xyz); search facility in PERL script. Includes bibliographical references. Text, numeric and representational data System requirements: for text, any standard web browser on any platform, Netscape 2.x or higher, Internet Explorer 3.x or higher; for molecular structures, viewer such as Rasmol or preferably MDL's Chemscape Chime; for search facility , an appropriately configured web server. Links to all required software for browsing on various platforms are included in the software directory in the thesis. Mode of access: World Wide Web.
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Greenwood, Jeremy Robert. "Pyridazinediones and amino acid receptors: theoretical studies, design, synthesis, and evaluation of novel analogues." University of Sydney, Department of Pharmacology, 1999. http://hdl.handle.net/2123/394.

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http://www.pharmacol.usyd.edu.au/thesis This thesis is primarily concerned with a class of chemical compounds known as pyridazinediones, being 6-membered aromatic rings containing two adjacent nitrogen atoms (pyridazine), doubly substituted with oxygen. In particular, the work focuses on pyridazine-3,6-diones, derivatives of maleic hydrazide (1). Understanding of the chemistry of these compounds is extended, using theoretical and synthetic techniques. This thesis is also concerned with two very important classes of receptors which bind amino acids in the brain: firstly, the inhibitory GABA receptor, which binds g-aminobutyric acid (GABA) (2) in vivo, and for which muscimol (3) is an agonist of the GABAA subclass; secondly, Excitatory Amino Acid (EAA) receptors, which bind glutamate (4) in vivo, and in particular the AMPA subclass, for which (S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) (5) is an agonist. The connection between pyridazinediones and amino acid receptors is the design, synthesis, and evaluation of structures based on pyridazinediones as potential GABA and EAA receptor ligands. Techniques of theoretical chemistry, molecular modelling, synthetic chemistry, and in vitro pharmacology are used to explore pyridazine-3,6-dione derivatives as ligands.
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Moniot, Aurélie. "Etude des effets anti-inflammatoires et anti-cancéreux de nouvelles molécules agrosourcées à motif pyridazinone Synthesis and biological evaluation of pyridazinone derivatives as potential antiinflammatory agents Osteoinductive Material to Fine-Tune Paracrine Crosstalk of Mesenchymal Stem Cells With Endothelial Cells and Osteoblasts." Thesis, Reims, 2020. http://www.theses.fr/2020REIMS022.

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L’ostéosarcome est un cancer primitif rare de l’os dont les approches thérapeutiques actuelles sont encore malheureusement insuffisantes pour espérer une totale guérison, et pour lequel la recherche de nouvelles molécules efficaces est constante. De plus, après exérèse de la tumeur, le défaut généré peut nécessiter de recourir à des matériaux aidant la reconstruction osseuse. Or le potentiel inflammatoire de ces matériaux est bien documenté. Les inhibiteurs de phosphodiestérase de type 4, parmi lesquels des molécules à motif pyridazinone, ont d’ores et déjà fait leurs preuves en tant qu’agents anti-cancéreux et anti-inflammatoires dans un certain nombre de modèles cellulaires. L’objectif de ce travail a été d’évaluer les effets anti-cancéreux et anti-inflammatoires de nouvelles molécules à motif pyridazinone dérivant de précurseurs agrosourcées. Les effets anti-inflammatoires ont été validés sur la production cytokinique, le potentiel migratoire et le maintien des capacités phagocytaires des neutrophiles primaires humains in vitro et dans un modèle murin d’inflammation in vivo. Ces molécules ont également montré leur potentiel thérapeutique dans des modèles d’ostéosarcomes in vitro où elles sont en capacité de bloquer la prolifération et la migration cellulaire tout en induisant l’apoptose des cellules cancéreuses. In vivo ces molécules sont capables de ralentir la progression tumorale et de maintenir la qualité minérale osseuse. Les résultats obtenus indiquent que ces nouvelles molécules à motif pyridazinone pourraient s’intégrer dans des polythérapies pour leurs potentiels thérapeutiques à la fois anti-cancéreux et anti-inflammatoire
Osteosarcoma is a rare primary bone cancer for which current therapeutic approaches are unfortunately insufficient to provide a total cure. So the need for new molecules development is constant. In addition, after tumor excision, bone defect may require materials to fill and support bone rebuilding. The inflammatory potential of such materials is well documented. Phosphodiesterase type 4 inhibitors, including pyridazinone-scaffold based molecules, have already proven themselves as anti-cancer and anti-inflammatory agents in a number of in vitro models. The goal of this work was to assess the anti-cancer and anti-inflammatory effects of new pyridazinone-scaffold based molecules derived from agrosourced precursors. Anti-inflammatory effects have been assessed on cytokine production, migratory potential and the phagocytic abilities of human primary neutrophils in vitro and in an in vivo model of inflammation in mice. These molecules have also shown their therapeutic potential in in vitro osteosarcoma models where they decreased cell proliferation and migration while inducing apoptosis in cancer cells. In vivo, these molecules were able to decrease tumor growth and maintain mineral bone quality. These results indicated that new pyridazinone scaffold-based molecules might be integrated into a multi-therapy, both for their anti-cancer and anti-inflammatory therapeutic potential
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Byrichetti, Kiranmai. "Synthesis and Structure of a Substituted Pyridazine." TopSCHOLAR®, 2011. http://digitalcommons.wku.edu/theses/1080.

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Pyridazines are heterocyclic compounds with an N-N bond in their ring structure. Heterocyclic aromatic compounds are of great interest as a result of their novel properties and commercial applications. Our current research is focused on the potential role of pyridazines in next generation electronic devices that utilize organics as the semiconducting material. The synthesis of 5, 6-fused ring pyridazines beginning from fulvenes (Scheme 1) is described herein. These fused heterocycles will serve as synthetic models and building blocks for potential organic or organometallic conducting polymers. Our goal was to modify the route of Snyder et al. previously reported for the direct synthesis of pyridazine 2. This required improved synthesis of fulvene 1 and higher yields of 5. Additionally, a thorough analysis of the x-ray data was obtained to better understand the 3D aspects of this compound (pyridazine 2).This route was quite general and features an efficient and convenient synthesis. Single crystal X-ray analysis confirms the molecular structure of pyridazine 2. Full synthesis and characterization of newly formed pyridazine 2 and Fulvene 1 are reported.
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Greenwood, Jeremy R. "Pyridazinediones and amino acid receptors theoretical studies, design, synthesis and evaluation of novel analogues /." [Sydney : J. Greenwood], 1999. http://www.pharmacol.usyd.edu.au/thesis.

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Thesis (Ph. D.)--Dept. of Pharmacology, University of Sydney, 1999.
Title from title screen. Interactive three dimensional molecular data and multiple colour images. Text presented in Hypertext Markup Language (.htm); images in standard formats (.jpg, .gif); molecules presented mostly as Cambridge Protein Data Bank format (.pdb); some molecules presented in alternative X. Mol cartesian co-ordinates format (.xyz); search facility in PERL script. Includes bibliographical references. A printed form was produced with limited features as a Faculty requirement; may also be issued in CD-ROM.
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Moreau, Stéphane. "5-benzyl-6-methyl-pyridazines fonctionnalisees et systemes bicycliques condenses : syntheses, etudes pharmacologiques et modelisation moleculaire." Clermont-Ferrand 1, 1996. http://www.theses.fr/1996CLF1PP03.

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Mernari, Bouchaïb. "Complexes binucléaires de dérivés de la pyridazine ou du pyrazole synthèses, structures cristallines et interactions magnétiques /." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37607939k.

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Thomas, Jaron Michael. "On Metal synthesis of Some Substituted Rhenium and Manganese Complexes." TopSCHOLAR®, 2012. http://digitalcommons.wku.edu/theses/1225.

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Heterocyclic organic and organometallic compounds (i.e. polypyrrole), and their derivatives, have been of great interest for conductive polymers due to their novel properties and environmental stability as compared to their non-aromatic analogs (i.e. polyacetylene). Our current interest focus upon the potential role of metal ligand bound pyridazines as the next generation of electronic devices that utilize the metal ligands bound to organics as the semiconducting material. Pyridazine is a 6-membered aromatic ring with two adjacent nitrogen atoms. These are promising candidates for a variety of materials and commercial applications; but they are difficult to get a metal ligand to fuse to the aromatic ring. Our recent efforts focused in attaching Rhenium and Manganese ligands/substituents (process in which is called doping) that would cause oxidation to occur to our polymer making it a p-type polymer. Since p-type polymers charge carriers leave a vacancy that does not delocalize completely. This vacancy (known as a hole) or a radical cation that only partially delocalizes over several monomeric units causing them to be structurally deformed. This deformed structure is at a higher energy than that of an undoped polymer. Typical carriers in organic semiconductors are holes and electrons in a π-orbital. So when these molecules of π-conjugated systems have a π-bond overlap (or π- stacking), electrons can move via these π-electron clouds overlapping thus causing an electrical current. Our worked focused on the synthesis of pyridazines and their organometallic rhenium complexes and polymer research. Several aryl-substituted 5,6-fused pyridazines have been synthesized but none have been documented until this study. The main goal of the research was to fully characterize the general synthesis of furan containing organometallic complexes, [M(CO)3{η5-1,2-C5H3(CC4H3ON)(CC4H3ON)}] (M = Re or Mn) (4B). We successfully characterized the ability to attach a metal organic ligand to pyridazine though IR and NMR. However, when attempts were made to recrystallize our product, we yielded an orange-brown, block like crystal of 1,2- C5H3(CC4H3ONH)(CC4H3ON) (5) in which our metal ligand group fell off and we were left with pyridazine and inorganics. Though, we successfully got an X-ray characterization and electronic studies of compound 5 which are reported herein.
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Scott, Joseph Brian. "Synthesis and Characterization of Some Rhenium Complexes." TopSCHOLAR®, 2009. http://digitalcommons.wku.edu/theses/114.

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Plastics or polymers are thought to behave oppositely from metals. Ideally, polymers behave as insulators while metals conduct electricity. Shirakawa and coworkers discovered conductive polymers in 1977.1 These conductor polymers have been extensively studied, discovering that charge transfer oxidative doping of polyacteylene could increase its conductivity by 12 orders of magnitude. Polyacetylene, although showing promise as an organic conductor, because it is highly air-sensitive and oxidizes when exposed to molecular oxygen, therefore making this an unattractive use for commercial products. Attention has been focused on heterocylic aromatic polymers such as polythiophene and polypyrrole, in efforts to produce conductive polymers that are air-stable, tractable, and have a low band gap. The lone-pair electrons of the sulfur and nitrogen atoms tend to stabilize the positive charges of the p-doped polymers through resonance. 2 By using Shirakawas’ idea of using polypyrrole as the focus point of our research and expanding upon that by the addition of a rhenium metal to an organic compound, (1,2-C5H3(CNR)2) and this should offer some new and interesting chemical properties. These new properties are; new optical properties, new electronic properties, improved physical properties, and a reversible electrochemical shift. This research will help in the field of organometallic semiconductors in applications such as OLED’s, and electrochromic windows.3-6
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Mykhaylychenko, Sergiy. "Study of perfluoroketene dithioacetals and N,S-acetals for the synthesis of fluorinated acyclic and heterocyclic compounds." Rouen, 2008. http://www.theses.fr/2008ROUES066.

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Les dithioacétals de perfluorocétènes sont des « synthons » simples et polyvalents pour la synthèse d'une large variété de composés fluorés acycliques et cycliques. Des transformations efficaces et directes des g-lactones a,b-insaturées en g-lactames et en pyridazin-3-ones substitués par un groupement 2,2,2-trifluoroéthyle ont été effectuées, à partir d'amines primaires et d'hydrazines variées et des dithioacétals de perfluorocétènes. La structure de tous les nouveaux composés a été assignée en utilisant les données de RMN (19F, 1H, 13C), d'IR et de MS et par diffraction des rayons X. Les réactions des polyfluorothioamides N-monosubstitués avec des réactifs organolithiums ont été étudiées. Dans le cas des polyfluorothioamides N,N-disubstitués, les N,S-acétals ont été obtenus. Les propriétés chimiques des N,S-acétals de perfluorocétènes, incluant les réactions d'oxydation et de chloration, ont été étudiées. La réaction d'oxydation des N,S-acétals de perfluorocétènes avec l'hydroperoxyde de tertbutyle a conduit à la formation d'un a-hydroperfluoroamide. La chloration des N,S-acétals de perfluorocétènes avec le chlorure de sulfuryle a donné des a-chloroperfluoroamides ; cette méthode s'est avérée une nouvelle approche pour la synthèse des composés polyfluorés a-chlorés optiquement actifs. Les mécanismes possibles pour ces transformations ont été discutés
Perfluoroketene dithioacetals are simple and highly versatile building-blocks for the synthesis of various fluorinated acyclic and heterocyclic compounds. Efficient and straightforward transformation of a,b-unsaturated g-lactones into 2,2,2-trifluoroethyl substituted γ-lactams and pyridazin-3-ones was performed, starting from a variety of primary amines or hydrazines and perfluoroketene dithioacetatals. The structures of all new compounds were ascribed using NMR (19F, 1H, 13C), IR, MS data and X-ray diffraction analysis. The possible mechanisms for the formation of γ-lactams and pyridazin-3-ones are also presented. The reactions of N-monosubstituted polyfluorothioamides with alkyllithium reagents were studied. In the case of N,N-disubstituted perfluorothioamides N,S-acetals were obtained. Some chemical properties of perfluoroketene-N,S-acetals, including oxidation and chlorination reactions, were investigated. Oxidation reaction of perfluoroketene-N,S-acetals with t-butylhydroperoxide led to a formation of a-hydroperfluoroamides. Chlorination of perfluoroketene-N,S-acetals with sulfuryl chloride gave a-chloroperfluoroamides; this method proved to be a new approach in the synthesis of polyfluorinated a-chloro optically active compounds. The possible mechanisms for these transformations are discussed
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Books on the topic "Pyridazinone Synthesis"

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Cinnolines and phthalazines: Supplement 2. Hoboken, N.J: Wiley, 2005.

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Book chapters on the topic "Pyridazinone Synthesis"

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Amoo, Victor E., Charles R. Harrison, George P. Lahm, Patrick D. Lowder, Thomas M. Stevenson, Jeffrey K. Long, Rafael Shapiro, et al. "Pyridazine Insecticides: Synthesis and Biological Activity." In ACS Symposium Series, 156–65. Washington, DC: American Chemical Society, 2001. http://dx.doi.org/10.1021/bk-2002-0800.ch015.

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Joule, J. A., K. Mills, and G. F. Smith. "The diazines: pyridazine, pyrimidine and pyrazine: reactions and synthesis." In Heterocyclic Chemistry, 189–224. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-3222-8_11.

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Shaner, Dale L., Laurine M. Speltz, and Stephen S. Szucs. "Synthesis and Herbicidal Activity of Pyridazines Based on 3-Chloro-4-methyl-6-[m-(trifluoromethyl)phenyl]pyridazine." In ACS Symposium Series, 24–35. Washington, DC: American Chemical Society, 1987. http://dx.doi.org/10.1021/bk-1987-0355.ch003.

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Lee, Seung Hee, Won Hee Han, Hyun Seo Shin, and Sang Jin Lee. "Synthesis of Phosphorescent Platinum Complexes with 3-Aryl Pyridazine as Prominent Emitting Materials in Organic Light-Emitting Device." In Key Engineering Materials, 1006–10. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-958-x.1006.

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Unger, Thomas A. "Pyridazines pyridazinones pyridazinediones." In Pesticide Synthesis Handbook, 518. Elsevier, 1996. http://dx.doi.org/10.1016/b978-081551401-5.50406-8.

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Harris, P. A. "10.24.5 Product Subclass 5: Pyridazino[1,6-a]indoles and Related Benzo-Fused Ring Systems." In Science of Synthesis: Knowledge Updates 2021/3. Stuttgart: Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/sos-sd-110-02114.

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AbstractThe synthesis of pyridazino[1,6-a]indoles, as well as the related indolo[1,2-b]cinnolines and indolo[2,1-a]phthalazines, are reviewed in this chapter. The most utilized methods to access pyridazino[1,6-a]indoles involve annulation of 1H-indol-1-amine derivatives.
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Wu, Xiao-Feng, and Zechao Wang. "Synthesis of Pyridazine." In Transition Metal Catalyzed Pyrimidine, Pyrazine, Pyridazine and Triazine Synthesis, 73–77. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-809378-8.00004-3.

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Hilmy Elnagdi, Mohamed, Nouria A. Al-Awadi, and Ismail Abdelshafy Abdelhamid. "Chapter 1 Recent Developments in Pyridazine and Condensed Pyridazine Synthesis." In Advances in Heterocyclic Chemistry, 1–43. Elsevier, 2009. http://dx.doi.org/10.1016/s0065-2725(08)00201-8.

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Wu, Xiao-Feng, and Zechao Wang. "Synthesis of Pyrimidine." In Transition Metal Catalyzed Pyrimidine, Pyrazine, Pyridazine and Triazine Synthesis, 5–54. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-809378-8.00002-x.

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Wu, Xiao-Feng, and Zechao Wang. "Synthesis of Pyrazine." In Transition Metal Catalyzed Pyrimidine, Pyrazine, Pyridazine and Triazine Synthesis, 55–71. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-809378-8.00003-1.

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Conference papers on the topic "Pyridazinone Synthesis"

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El Rayes, Samir M. "Convenient Synthesis and Antimicrobial Activity of Some Novel Pyridazinone Bearing Triazole Moieties." In The 14th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2010. http://dx.doi.org/10.3390/ecsoc-14-00493.

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Mátyus, Péter, Olivér Éliás, Lázló Károlyházy, Géza Stájer, Veronika Harmath, and Orsolya Barabás. "Ring Closure Reactions of 4-Chloro-5-hydroxyalkylamino-6-nitro-3(2H)- pyridazinones: Synthesis of Novel Pyridazino-Fused Ring Systems." In The 4th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01820.

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Salaheldin, Abdellatif, Lígia Rodrigues, and Ana Oliveira-Campos. "Heterocyclic Synthesis with Nitriles: Synthesis of Pyridazine and Pyridopyridazine Derivatives." In The 11th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2007. http://dx.doi.org/10.3390/ecsoc-11-01319.

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Schnell, Barbara, and Thomas Kappe. "Rearrangement of Heterocycles via-2-oxoketenes: Synthesis and Rearrangement Reactions of Cross-Conjugated Mesomeric Pyridazino[2,3-a]pyrimidine." In The 4th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01844.

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Hosmane, Ramachandra, and Huan-Ming Chen. "Synthesis of 1-(2'-Deoxy-γ-D-ribofuranosyl)-1H-imidazo[4,5-d]pyridazine-4,7(5 H,6H)-dion: a Potentially Beneficial Building Block for Antisense Applications." In The 4th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01926.

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Hosmane, Ramachandra, and Huan-Ming Chen. "Synthesis of 1-(2'-O-Methyl-γ -D-Ribofuranosyl)-1H-imidazo[4,5-d]pyridazine-4,7(5H,6H)-dion: an Attractive Building Block for Antisense and Triple-helical Applications." In The 4th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01925.

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Troitskaya-Markova, Nadezhda, Olga Vlasova, and Oleg Rakitin. "4,5-DIOXO-4,5-DIHYDRO-4Λ4,5Λ4-BIS([1,2,5]OXADIAZOLO)[3,4-с:3',4'-e]PYRIDAZINE AS A SYNTHETIC EQUIVALENT OF 4,4'-DINITROSO-3,3'-BI(1,2,5-OXADIAZOLE)." In Chemistry of nitro compounds and related nitrogen-oxygen systems. LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m779.aks-2019/305-307.

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