Log in

Relevant bibliographies by topics / Pyridine derivative / Journal articles

To see the other types of publications on this topic, follow the link: Pyridine derivative.

Journal articles on the topic 'Pyridine derivative'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Pyridine derivative.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Gad-Elkareem, Mohamed A. M., Azza M. Abdel-Fattah, and Mohamed A. A. Elneairy. "Pyrazolo[3,4-b]pyridine in heterocyclic synthesis: synthesis of new pyrazolo[3,4-b]pyridines, imidazo[1',2':1,5]pyrazolo[3,4-b]pyridines, and pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidines." Canadian Journal of Chemistry 85, no. 9 (2007): 592–99. http://dx.doi.org/10.1139/v07-089.

Full text

Abstract:

Pyrazolo[3,4-b]pyridine derivatives 7 and 9 were synthesized via the reaction of 3-amino-1H-pyrazolo-[3,4-b]pyridine derivative 2 with ω-bromoacetophenones. Reaction of 7 and 9 with Ac2O afforded the imidazo[1',2':1,5]py razolo[3,4-b]pyridine derivative 8 and pyrazolo[3,4-b]pyridine derivative 10, respectively. Reaction of 2 with chloroacetonitrile followed by DMF-DMA gave imidazo[1',2':1,5]pyrazolo[3,4-b]pyridines 4 and 5, respectively. Acetyl acetone and 1,1-dicyano-2,2-dimethylthioethene were reacted with 2 to afford the pyrido[2',3':3,4]pyrazolo-[1,5-a]-pyrimidines 11 and 14, respectively.

APA, Harvard, Vancouver, ISO, and other styles

2

Norman, Rebecca E., Michael V. Perkins, Andris J. Liepa, and Craig L. Francis. "N,N-Dialkyl-N′-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. Part X. The First Pyrazolo[1,5-b][1,2,4,6]thiatriazine Derivatives and their Unusual Reactions with Acylating Agents." Australian Journal of Chemistry 66, no. 11 (2013): 1323. http://dx.doi.org/10.1071/ch13282.

Full text

Abstract:

N,N-dialkyl-N′-chlorosulfonyl chloroformamidines 1 underwent a regioselective reaction with 3-aminopyrazoles 2 to produce pyrazolo[1,5-b][1,2,4,6]thiatriazines 3, representatives of a new ring system. Attempted N-acylation of compounds 3 with acetic anhydride (or chloride) and benzoyl chloride in pyridine, only afforded 5-(pyridin-4-yl)-pyrazolo[1,5-b][1,2,4,6]thiatriazine derivatives 11. The analogous reaction with pyridazine led to the corresponding pyridazin-4-yl derivative.

APA, Harvard, Vancouver, ISO, and other styles

3

Abdel-Rahman, Adel A. H., Amira K. F. Shaban, Ibrahim F. Nassar, et al. "Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity." Molecules 26, no. 13 (2021): 3923. http://dx.doi.org/10.3390/molecules26133923.

Full text

Abstract:

New pyridine, pyrazoloyridine, and furopyridine derivatives substituted with naphthyl and thienyl moieties were designed and synthesized starting from 6-(naphthalen-2-yl)-2-oxo-4-(thiophen-2-yl)-1,2-dihydropyridine-3-carbonitrile (1). The chloro, methoxy, cholroacetoxy, imidazolyl, azide, and arylamino derivatives were prepared to obtain the pyridine-‑C2 functionalized derivatives. The derived pyrazolpyridine-N-glycosides were synthesized via heterocyclization of the C2-thioxopyridine derivative followed by glycosylation using glucose and galactose. The furopyridine derivative 14 and the tricy

APA, Harvard, Vancouver, ISO, and other styles

4

Raev, Lyubomir Dimitrov, Ivo Christov Ivanov, and Silviya Georgieva Agontseva. "Addition of some 6-amino-4-aryl-2(1H)-pyridones to phenylisocyanate and related reactions." Zeitschrift für Naturforschung B 74, no. 2 (2019): 191–95. http://dx.doi.org/10.1515/znb-2018-0184.

Full text

Abstract:

AbstractThe Michael addition of enaminoesters to coumarins leads to the formation of the rearranged adduct 1 whose structure has been previously elucidated by X-ray crystallographic analysis. Now, N- and/or O-carbamoylation of the 6-amino-2-pyridone 1 by treatment with phenyl isocyanate in a molar ratio of 1:1 and 1:2 gave N-mono- (2a) or N,O-bis-(phenylcarbamoyl) (3) derivatives, respectively. Further transformations of the corresponding new 2-pyridone derivative 2a into the O-acetyl derivative 2b and the chromeno[3,4-c]pyridine 4 are reported as well.

APA, Harvard, Vancouver, ISO, and other styles

5

Hafez, Hend N., and Abdel-Rahman B. A. El-Gazzar. "Synthesis of Novel Pyridine Bearing Biologically Active Imidiazolyl, Pyrazolyl, Oxa/thiadiazolyl and Urea Derivatives as Promising Anticancer Agents." Current Organic Synthesis 17, no. 1 (2020): 55–64. http://dx.doi.org/10.2174/1570179417666191223163225.

Full text

Abstract:

Background: A novel series of pyridine containing 1,3,4-oxa/thiadiazol derivatives 4a,b, pyrazole derivatives 5-7, thiazole derivatives 9a,b and 17a-c, urea derivatives 12a-c, imidiazole derivative 16, imidazo[1,2-a]pyridine derivatives 18a, b, tetrazole 19, pyrane 20 and pyridine derivatives 21 has been synthesized. Objective: This research aims to synthesize 6-(Trifluoromethyl)-2-[3-(trifluoromethyl)phenyl] amino nicotinohydrazide 2 and 6-(trifluoromethyl)-2-[3-(trifluoromethyl)phenyl]amino pyridin-3-carboaldhyde 15 as key intermediate for the synthesis of novel pyridine derivatives bearing

APA, Harvard, Vancouver, ISO, and other styles

6

Chiassai, Leonardo, Rafael Ballesteros-Garrido, Maria Paz Clares, Enrique García-España, Rafael Ballesteros, and Belén Abarca. "Combining Amines and 3-(2-Pyridyl)-[1,2,3]Triazolo[1,5-a]pyridine: An Easy Access to New Functional Polynitrogenated Ligands." Synthesis 51, no. 21 (2019): 4034–42. http://dx.doi.org/10.1055/s-0037-1611901.

Full text

Abstract:

Triazolopyridine-pyridine amine ligands are easily obtained by means of either thermal- or copper(II)-mediated reactions. Starting from a readily accessible iodo derivative of triazolopyridine-pyridine and different amines, this new family of compounds combines aromatic and aliphatic nitrogen atoms with promising coordinating properties. Furthermore, chemical derivatization of a new triazolopyridine-pyridine diamine compound, N1-[6-([1,2,3]triazolo[1,5-a]pyridin-3-yl)pyridin-2-yl]ethan-1,2-diamine, allows the preparation of several remote-pyridine-containing ligands.

APA, Harvard, Vancouver, ISO, and other styles

7

Grinberga, S., A. Krauze, L. Krasnova, and G. Duburs. "Synthesis of 4-Benzo[1,3]Dioxol-5-Ylthieno-[2,3-b]Pyridines." Latvian Journal of Chemistry 51, no. 1-2 (2012): 143–48. http://dx.doi.org/10.2478/v10161-012-0002-2.

Full text

Abstract:

Synthesis of 4-Benzo[1,3]Dioxol-5-Ylthieno-[2,3-b]Pyridines 4,7-Dihydrothieno[2,3-b]pyridine 4 and thieno[2,3-b]pyridine 6 were obtained by Thorpe-Ziegler cyclization. Mn(OAc)3/acetic acid system had been used for oxidation of 1,4-dihydropyridine 3 to pyridine derivative 5. 6-Carbamoylmethylsulfanyl-1,4-dihydropyridine 3 was prepared by al-kylation of piperidinium 1,4-dihydropyridine-2-thiolate 1 with iodoacet-amide.

APA, Harvard, Vancouver, ISO, and other styles

8

Laxmi, Dandamudi Sri, Suryadevara V. Vardhini, Venkata R. Guttikonda, Mandava V. B. Rao, and Manojit Pal. "Synthesis of 2-substituted Furo[3,2-b]pyridines Under Pd/C-Cu Catalysis Assisted by Ultrasound: Their Evaluation as Potential Cytotoxic Agents." Anti-Cancer Agents in Medicinal Chemistry 20, no. 8 (2020): 932–40. http://dx.doi.org/10.2174/1871520620666200311102304.

Full text

Abstract:

Background: Compounds containing furo[3,2-b]pyridine framework have shown interesting pharmacological properties, including anticancer activities. Though these compounds are generally synthesized via the heteroannulation processes involving acetylenic derivatives, some of them are complex. Objective: The study aimed to explore a series of 2-substituted furo[3,2-b]pyridines for their cytotoxic properties against cancer cell lines in vitro. Methods: We developed a convenient synthesis of 2-substituted furo[3,2-b]pyridines via sequential (i) C-C coupling followed by (ii) C-O bond-forming reaction

APA, Harvard, Vancouver, ISO, and other styles

9

Al-Amiery, A. A., and L. M. Shaker. "Corrosion inhibition of mild steel using novel pyridine derivative in 1 M hydrochloric acid." Koroze a ochrana materialu 64, no. 2 (2020): 59–64. http://dx.doi.org/10.2478/kom-2020-0009.

Full text

Abstract:

AbstractA novel pyridine derivative was synthesized, and its corrosion inhibition effects on mild steel in a 1M hydrochloric acid environment were investigated by gravimetric techniques, The results demonstrated that the inhibitive performance increased with the increasing of inhibitor concentration. At 303, the inhibition efficiency of pyridine derivative 4-hydroxy-3-(pyridin-2-ylaminomethyl)toluene accomplished 96.2% at the inhibitor concentration of 0.005 M. The mechanism of inhibition implicated the forming of a protective layer from inhibitor molecules on the surface of mild steel by a La

APA, Harvard, Vancouver, ISO, and other styles

10

Mohammed, Tiba Ibrahim. "Synthesis of New Azo–Schiff Base Complexes and Study of their Antibacterial Activity." International Journal Papier Advance and Scientific Review 4, no. 1 (2023): 42–56. http://dx.doi.org/10.47667/ijpasr.v4i1.206.

Full text

Abstract:

In this research, we synthesized new azo-schiff base derivatives (4-9). These derivatives of azo compounds (1-3) that synthesized from 4-ethoxyaniline and drivatives of aldehyde such as, 4-aminobenzaldehyde, 4- hydroxybenzaldehyde and 4-ethoxybenzaldehyse to produce azo compounds (1-3). The compounds (1-3) reacted with differents aldehyde such as, isonicotinic hydrazide to produce N'-[(Z)-{3-[(E)-(4-ethoxyphenyl)diazenyl]-4-subs.phenyl}-methylidene]pyridine-4-carbohydrazide derivatives (4-6) and 3-amino pyridine to produce 2-[(E)-(4-ethoxyphenyl)diazenyl]-4-{(E)-[(pyridin-3-yl)imino]-methyl}su

APA, Harvard, Vancouver, ISO, and other styles

11

Gu, Guoliang, and Ming Lu. "A new facile synthesis of dimethyl 4-(2-(2,6-bis(methoxycarbonyl)pyridin-4-yl)vinyl) pyridine-2,6-dicarboxylate." Macedonian Journal of Chemistry and Chemical Engineering 29, no. 2 (2010): 165. http://dx.doi.org/10.20450/mjcce.2010.163.

Full text

Abstract:

A new facile synthesis of pyridine dicarboxylic acid derivative, dimethyl 4-(2-(2,6-bis(methoxycarbonyl)pyridin-4-yl)vinyl)pyridine-2,6-dicarboxylate (DVDPA), from dimethyl 4-(chloromethyl)pyridine-2,6-dicarboxylate (CMDPA) in presence of nitrogen bases has been described. The influences of different base/CMDPA molar ratio and different nitrogen bases were also investigated. The result has shown that the yield could reach 81 % when triethylamine was used and the molar ratio of base/CMDPA was 2.4. The overall yield of title compound via the three-step synthesis starting from dimethyl 4-(hydroxy

APA, Harvard, Vancouver, ISO, and other styles

12

Bedair, A. H., Abd El-Wahab, A. M. El-Agrody, F. M. Ali, A. H. Halawa, and G. M. El-Sherbiny. "Binary heterocyclic systems containing the ethylideneamino linkage: synthesis of some new heterocyclic compounds bearing the naphtho-[2,1-b]furan moiety." Journal of the Serbian Chemical Society 71, no. 5 (2006): 459–69. http://dx.doi.org/10.2298/jsc0605459b.

Full text

Abstract:

Ethylidene hydrazine (4a,b) and thiazolidin-4-one (5) derivatives were synthesized by the reaction of ethylidenethiosemicarbazide derivative (3a) with ?-haloketone/ethyl bromoacetate, respectively. Hetrocyclization of ethylideneacetohydrazide derivative (7) with o-phenolic aldehydes gave the corresponding coumarin derivatives (8,9). The interaction of 7 with acetylacetone afforded the corresponding pyridine derivative (10). Treatment of the arylidene derivative 11b with malononitrile afforded the corresponding pyran derivative (12). The new products 3-12 were subjected to IR, 1H NMR and mass s

APA, Harvard, Vancouver, ISO, and other styles

13

Muttaqin, Fauzan Zein, Taufik Muhammad Fakih, and Hubbi Nashrullah Muhammad. "MOLECULAR DOCKING, MOLECULAR DYNAMICS, AND IN SILICO TOXICITY PREDICTION STUDIES OF COUMARIN, N-OXALYLGLYCINE, ORGANOSELENIUM, ORGANOSULFUR, AND PYRIDINE DERIVATIVES AS HISTONE LYSINE DEMETHYLASE INHIBITORS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 12 (2017): 212. http://dx.doi.org/10.22159/ajpcr.2017.v10i12.19348.

Full text

Abstract:

Objective: Prostate cancer is the second most common cancer in men. One of the efforts in the treatment of prostate cancer is by inhibiting histone lysine demethylase. Derivative compounds of coumarine, N-oxalylglycine, organoselenium, organosulfur, and pyridine have been reported to be active against two types of histone lysine demethylase (KDM) enzymes, KDM4E and KDM5B. This study aims to study the interactions of these derivatives with KDM.Methods: In this study, we performed computational studies, including molecular docking and molecular dynamics (MDs) simulations, and toxicity prediction

APA, Harvard, Vancouver, ISO, and other styles

14

Marchalín, Štefan, and Josef Kuthan. "Synthesis of 3,5-dicyano-4-phenyl-2,6-bis(4-p-terphenylyl)-1,4-dihydropyridine. An attempt at extending the Hantzsch synthesis." Collection of Czechoslovak Chemical Communications 50, no. 9 (1985): 1962–70. http://dx.doi.org/10.1135/cccc19851962.

Full text

Abstract:

The 3-oxopropanenitrile IIIc, prepared from 4-acetyl-p-terphenyl (IV) by the sequence IV → V → VI → IIIc, reacts with benzaldehyde and ammonium acetate in acetic acid to give the Hantzsch 1,4-dihydropyridine VIIc and the corresponding pyridine derivative VIIIc. The alternative cyclocondensation of benzylidene derivative IIc and 3-oxopropanenitrile IIIc in the presence of ammonium acetate exclusively gives the pyridine derivative VIIIc. Rate of thermal and oxidative aromatizations of the 1,4-dihydropyridine derivatives, VIIa → VIIc → VIIIa → VIIIc, decreases in the order VIIc > VIIb > VII

APA, Harvard, Vancouver, ISO, and other styles

15

Mistry, Rakesh N., and K. R. Desai. "Studies on Synthesis of Some Novel Heterocyclic Azlactone Derivatives and Imidazolinone Derivatives and their Antimicrobial Activity." E-Journal of Chemistry 2, no. 1 (2005): 42–51. http://dx.doi.org/10.1155/2005/542938.

Full text

Abstract:

p- Methyl benzoic acid on reaction with phosphorus pentachloride gives p - methyl benzoyl chloride derivative which on condensation with glycine gives p - methyl benzoyl glycine derivative. Now, this p - methyl benzoyl glycine derivative on condensation with various substituted aldehydes gives corresponding substituted 4 - [aryl methylidine] - 2 - [p - methyl phenyl] - oxazole - 5 - one derivatives [1(a-j)]. Further, these derivatives [1(a-j)] on condensation with 4 , 4’ - diamino diphenyl sulphone gives corresponding substituted imidazolinone - dibenzsulphone derivatives [2(a-j)], on condensa

APA, Harvard, Vancouver, ISO, and other styles

16

Nishimura, Takahiro, Ryota Yabe, and Yusuke Ebe. "Iridium-Catalyzed Direct C–H Allylation of Ketimines." Synthesis 53, no. 17 (2021): 3051–56. http://dx.doi.org/10.1055/a-1477-7059.

Full text

Abstract:

AbstractAromatic C–H allylation of N-sulfonyl ketimines with allyl alcohol or allyl phenyl ether as an allyl source is catalyzed by a cationic iridium complex. The presence of a catalytic amount of a pyridine derivative was found to be essential for the reaction. In contrast, direct C–H allylation of ketimines derived from benzophenone derivatives and p-methoxyaniline with allyl phenyl ether proceeded in the absence of pyridine derivatives.

APA, Harvard, Vancouver, ISO, and other styles

17

Demirdogen, Ruken Esra, Tuncay Yeşilkaynak, Tetyana Tishakova, and Fatih Mehmet Emen. "Antibacterial Cellulose Acetate Microfibers Containing Pyridine Derivative Complexes." Chemistry & Chemical Technology 15, no. 2 (2021): 217–25. http://dx.doi.org/10.23939/chcht15.02.217.

Full text

Abstract:

Pyridine (L1) and 2,4-dimethylpyridine (L2) halide complexes of the type of [ML2X2] were prepared and characterized via FT-IR and 1H NMR. The CA microfibers containing complexes were electrospun and investigated via FT-IR. The morphologies of the microfibers were investigated via FE-SEM. Antibacterial activities of the complexes and the fibers were investigated.

APA, Harvard, Vancouver, ISO, and other styles

18

Nogueira, Thais Cristina Mendonça, Lucas dos Santos Cruz, Maria Cristina Lourenço, and Marcus Vinicius Nora de Souza. "Design, Synthesis and Anti-tuberculosis Activity of Hydrazones and N-acylhydrazones Containing Vitamin B6 and Different Heteroaromatic Nucleus." Letters in Drug Design & Discovery 16, no. 7 (2019): 792–98. http://dx.doi.org/10.2174/1570180815666180627122055.

Full text

Abstract:

Background: The term vitamin B6 refers to a set of six compounds, pyridoxine,pyridoxal ,and pyridoxamine and their phosphorylated forms, among which pyridoxal 5´-phosphate (PLP) is the most important and active form acting as a critical cofactor. These compounds are very useful in medicinal chemistry because of their structure and functionalities and are also used in bioinorganic chemistry as ligands for complexation with metals. Methods: In this study, a series of hydrazones 1a-g and N-acylhydrazones 2a-f containing vitamin B6 have been synthesized from commercial pyridoxal hydrochloride and

APA, Harvard, Vancouver, ISO, and other styles

19

Dabaeva, V. V., M. R. Bagdasaryan, E. G. Paronikyan, et al. "Synthesis of new condensed pyrano[4,3-<i>b</i>]pyridines based on ethyl-3-aminopyrano[4,3-<i>b</i>]thieno[3,2-<i>e</i>]pyridine2-carboxylate derivative." Журнал органической химии 59, no. 1 (2023): 119–27. http://dx.doi.org/10.31857/s051474922301010x.

Full text

Abstract:

Methods for the synthesis of new fused pyrano[4,3- b ]pyridine derivatives based on the ethyl-3-amino-pyrano[4,3- b ]thieno[3,2- e ]pyridine-2-carboxylate derivative have been developed. The interaction reactions of the condensed 3-(phenoxycarbonyl)-amino derivative with primary and secondary amines have been studied. It has been established that in the case of primary amines, the reaction is accompanied by cyclization with the formation of fused pyrimidines. However, when secondary amines are used, the structure of the final product depends on the reaction conditions. The antibacterial proper

APA, Harvard, Vancouver, ISO, and other styles

20

Mohareb, R. M., and S. M. Fahmy. "Reaction of Malononitrile and Ethyl Cyanoacetate: a Novel Synthesis of Polyfunctional Pyridine Derivatives." Zeitschrift für Naturforschung B 40, no. 11 (1985): 1537–40. http://dx.doi.org/10.1515/znb-1985-1120.

Full text

Abstract:

Malononitrile reacts with ethyl cyanoacetate to give a polyfunctional substituted pyridine derivative 5. The latter compound reacts with aniline, hydrazines and aromatic aldehydes to give condensated products. The active methylene of 5 couples with benzenediazonium chloride to give the phenylhydrazone derivative which cyclises readily to give a pyrido[2,3-d]pyridazine derivative. 5 reacts with trichloroacetonitrile, and carbon disulphide to give fused heterocyclic derivatives.

APA, Harvard, Vancouver, ISO, and other styles

21

Sozzi, Mattia, Michele R. Chierotti, Roberto Gobetto, et al. "One-Dimensional and Two-Dimensional Zn(II) Coordination Polymers with Ditopic Imidazo[1,5-a]pyridine: A Structural and Computational Study." Molecules 29, no. 3 (2024): 653. http://dx.doi.org/10.3390/molecules29030653.

Full text

Abstract:

Zn(II) coordination polymers are being increasingly studied for their stability and properties. Similarly, there is a growing interest in imidazo[1,5-a]pyridine derivatives, which show great potential in luminescence and pharmaceutical applications. In this work, we successfully synthesized and crystallized three new coordination polymers, using Zn(II) as the metallic node, dicarboxylic acids of different length and nature as linkers, and a linear ditopic imidazo[1,5-a]pyridine derivative, to explore the role of this molecule as a propagator of the dimensionality of the structure or as an anci

APA, Harvard, Vancouver, ISO, and other styles

22

Tepper, Christina, and Gebhard Haberhauer. "Toward unidirectional switches: 2-(2-Hydroxyphenyl)pyridine and 2-(2-methoxyphenyl)pyridine derivatives as pH-triggered pivots." Beilstein Journal of Organic Chemistry 8 (June 29, 2012): 977–85. http://dx.doi.org/10.3762/bjoc.8.110.

Full text

Abstract:

The pH-induced switching process of 2-(2-hydroxyphenyl)pyridine and 2-(2-methoxyphenyl)pyridine derivatives was investigated with the help of UV spectroscopy. Quantum chemical calculations at the B3LYP/6-31G* level of theory were performed to show that in the case of 2-(2-methoxyphenyl)-3-methylpyridine and 2-(2-hydroxyphenyl)-3-methylpyridine the rotation during the switching process proceeds unidirectionally at the molecular level. If a 2-(2-methoxyphenyl)pyridine derivative is fixed to a chiral cyclopeptidic scaffold, a unidirectional progress of the rotation is achieved macroscopically.

APA, Harvard, Vancouver, ISO, and other styles

23

Alghamdi, Adel, Amr S. Abouzied, Abdulwahab Alamri, et al. "Synthesis, Molecular Docking, and Dynamic Simulation Targeting Main Protease (Mpro) of New, Thiazole Clubbed Pyridine Scaffolds as Potential COVID-19 Inhibitors." Current Issues in Molecular Biology 45, no. 2 (2023): 1422–42. http://dx.doi.org/10.3390/cimb45020093.

Full text

Abstract:

Many biological activities of pyridine and thiazole derivatives have been reported, including antiviral activity and, more recently, as COVID-19 inhibitors. Thus, in this paper, we designed, synthesized, and characterized a novel series of N-aminothiazole-hydrazineethyl-pyridines, beginning with a N′-(1-(pyridine-3-yl)ethylidene)hydrazinecarbothiohydrazide derivative and various hydrazonoyl chlorides and phenacyl bromides. Their Schiff bases were prepared from the condensation of N-aminothiazole derivatives with 4-methoxybenzaldehyde. FTIR, MS, NMR, and elemental studies were used to identify

APA, Harvard, Vancouver, ISO, and other styles

24

Hakimi, Mohammad, Zahra Mardani, Keyvan Moeini, Fabian Mohr, Esther Schuh, and Hooshang Vahedi. "Synthesis, Crystallographic and Spectral Characterization of a Cadmium Chloride Complex Containing a Novel Imidazo[1,5-a]Pyridine Derivative." Zeitschrift für Naturforschung B 67, no. 5 (2012): 452–58. http://dx.doi.org/10.5560/znb.2012-0064.

Full text

Abstract:

The reaction between 2-(2-amino-ethylamino)ethanol and pyridine-2-carbaldehyde in a 1 : 3 molar ratio gave 3-(pyridin-2-yl)-1-(pyridin-2-ylmethyl)imidazo[1,5-a]pyridine (PPIP) which was characterized by elemental analysis and spectroscopic methods. The study of CSD-deposited structures revealed that PPIP is a new derivative of imidazo[1,5-a]pyridine. The cadmium chloride complex of this ligand [Cd(PPIP)Cl2][Cd(PPIP)Cl2]ʹ·3H2O (1) was prepared and identified by elemental analysis, FT-IR, Raman and 1H NMR spectroscopy, and single-crystal X-ray diffraction. In the crystal structure of 1, there ar

APA, Harvard, Vancouver, ISO, and other styles

25

Goyal, Rakesh, Mukesh Sharma, Dharmendra Ahuja, and Anurekha Jain. "Synthesis and Evaluation of Aldehyde Derivatives of Sulfonyl Chloride Quinoxaline." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 921–27. http://dx.doi.org/10.22270/jddt.v9i4-a.3142.

Full text

Abstract:

In pyrazine mesomeric interaction between the protonated & neutral nitrogen atoms probably destabilizes the cation.N, N’-diprotonation is very easier for pyrazine Synthesis of 2, 3-diphenylquinoxaline by phenylene-diamine in 16 ml of rectified spirit was added & combine solution was warm in water bath for 30 min. added water until slight colorless persist & allow to cool recrystallize the product in ethanol. Synthesis of 2, 3-diphenylquinoxaline 7-sulfonylchloride (R) using chlorosulfonic acid under ice-cold condition, then Synthesis of 2-hydroxyphenyl-2,3-diphenylquinoxaline-7-sul

APA, Harvard, Vancouver, ISO, and other styles

26

Swamy, M. Kumara, and K. Bhaskar. "Synthesis and Anticancer Activity of Novel Carbohydrazide and Carboxamide Derivatives of Pyridine Fused Heterocyclic Derivatives." Asian Journal of Chemistry 34, no. 10 (2022): 2683–87. http://dx.doi.org/10.14233/ajchem.2022.23875.

Full text

Abstract:

A series of novel carbohydrazide and carboxamide derivatives of hetero-fused pyridine derivatives were synthesized starting from bis-trifluoromethyl containing pyridine 1. Compound 1 on Smiles rearrangement obtained compound 2, then compound 2 on coupling with diethyl ethoxymethylenemalonate (EMME), further reaction with POCl3 and hydrazine hydrate to obtain pyridopyrimidine hydrazide derivatives. This hydrazide derivative reacts with different substituted aromatic aldehydes to produce title carbohydrazide derivatives 6a-h. Pyridopyrimidine carboxylate compound on reaction with aliphatic amine

APA, Harvard, Vancouver, ISO, and other styles

27

El-Hagrassey, Eman A., Ehab Abdel-Latif, and Gamal M. Abdel-Fattah. "Synthesis and efficiency of new pyridine, chromene and thiazole containing compounds as antimicrobial and antioxidant agents." Bulletin of the Chemical Society of Ethiopia 36, no. 1 (2022): 137–48. http://dx.doi.org/10.4314/bcse.v36i1.12.

Full text

Abstract:

ABSTRACT. The versatile scaffold, N'-(2-cyanoacetyl)-2-hydroxybenzohydrazide (3) was utilized in the production of new pyridine, chromene and thiazole derivatives as antimicrobial and antioxidant agents. The synthetic strategy involves the treatment of precursor 3 with various arylidene-malononitrile and 3-aryl-2-cyanoacrylate compounds to furnish substituted pyridines 5 and 7. The interaction of 3 with salicylaldehyde and/or phenyl isothiocyanate followed by cyclization with chloroacetone produced the corresponding 2-imino-2H-chromene-3-carbohydrazide and (thiazol-2-ylidene-acetyl)-salicylic

APA, Harvard, Vancouver, ISO, and other styles

28

Ma, Kuoyan, Liang Cheng, Han-Mou Gau, and Jingsong You. "A new chiral ligand: 2,6-bis[4(S)-isopropyl-1-phenyl-4,5-dihydro-1H-imidazol-2-yl]pyridine." Acta Crystallographica Section E Structure Reports Online 62, no. 4 (2006): o1595—o1597. http://dx.doi.org/10.1107/s1600536806009846.

Full text

Abstract:

The title compound, C29H33N5, is a new chiral bis(imidazolyl)pyridine derivative with a skeleton similar to the bis(oxazolyl)pyridine derivatives, which have been extensively used as ligands in various asymmetric catalytic reactions. The most prominent feature of the present compound is the considerable sp 2 character of N atoms of the imidazoline rings. The substituents at the Nsp 2 atoms can provide a means for tuning the electronic and conformational properties of the compound.

APA, Harvard, Vancouver, ISO, and other styles

29

Suchetan, Parameshwar Adimoole, Revanasiddappa Nadigar Mohan, Vijithkumar, Bandrehalli Siddagangaiah Palakshamurthy, and Swamy Sreenivasa. "6-Chloro-N-(pyridin-4-ylmethyl)pyridine-3-sulfonamide." Acta Crystallographica Section E Structure Reports Online 69, no. 12 (2013): o1765. http://dx.doi.org/10.1107/s1600536813030523.

Full text

Abstract:

In the title sulfonamide derivative, C11H10ClN3O2S, the dihedral angle between the pyridine rings is 46.85 (12)°. The N atom of the chloropyridine ring isantito the N—H bond. In the crystal, molecules are linked through N—H...N hydrogen bonds into zigzag chains parallel to [001] with aC(7) graph-set motif.

APA, Harvard, Vancouver, ISO, and other styles

30

Ryzhkova, Yuliya E., Fedor V. Ryzhkov, Oleg I. Maslov, and Michail N. Elinson. "2,4-Diamino-5-(5-hydroxy-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitrile." Molbank 2023, no. 1 (2023): M1541. http://dx.doi.org/10.3390/m1541.

Full text

Abstract:

5H-Chromeno[2,3-b]pyridines are important compounds with industrial, biological, and medicinal properties. In this short note, the multicomponent reaction of salicylaldehyde, malononitrile dimer, and 2-phenyl-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one in dimethyl sulfoxide at ambient temperature was investigated to give 2,4-diamino-5-(5-hydroxy-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitrile with good yield. The structure of the previously unknown chromeno[2,3-b]pyridine derivative was confirmed by elemental analysis, mass, nuclear magnetic resonan

APA, Harvard, Vancouver, ISO, and other styles

31

Ravinder Kumar, Deepika, Neelam, and Deepika Rani. "Advancements in pyridine-based charge transporting materials for perovskite solar cells." International Journal of Science and Research Archive 15, no. 1 (2025): 1080–86. https://doi.org/10.30574/ijsra.2025.15.1.1079.

Full text

Abstract:

The utilization of pyridine derivatives for their donor-acceptor nature has seen an impressive serge in research community over the globe. As these materials offer a variety of applications, ranging from thermally activated delayed fluorescence, organic solar cells, organic light emitting diodes (OLEDs) to even perovskite solar cells (PSCs). These derivatives are well-established as excellent electron transporting materials (ETMs) with better quantum and current efficiency, mainly due to excellent thermal stability of pyridine-based OLEDs devices. Pyridine derivative based hole transporting ma

APA, Harvard, Vancouver, ISO, and other styles

32

Kostenko, Nataliya, Jochen Gottfriedsen, Liane Hilfert, and Frank T. Edelmann. "A Synthetic Route to Quaternary Pyridinium Salt-Functionalized Silsesquioxanes." International Journal of Polymer Science 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/586594.

Full text

Abstract:

A synthetic route to potentially biocidal silsesquioxanes functionalized by quaternary pyridinium functionalities has been developed.N-Alkylation reactions of the precursor compounds 4-(2-(trimethoxysilyl)ethyl)-pyridine (5) and 4-(2-trichloro-silylethyl)pyridine (6) with iodomethane,n-hexylbromide, andn-hexadecylbromide cleanly afforded the correspondingN-alkylpyridinium salts (7–10). The synthesis of a 4-(2-ethyl)pyridine POSS derivative (2) was achieved by capping of the silsesquioxane trisilanol Cy7Si7O9(OH)3(1) via two different preparative routes. Attempts to use compound2as precursor fo

APA, Harvard, Vancouver, ISO, and other styles

33

Vadla, Balakishan, Naveen Puram, and Sailu Betala. "Novel trifluoromethyl-thieno[2,3-b]pyridine-2-carboxamide and Schiff’s base derivatives and their anticancer activity." Research Journal of Chemistry and Environment 27`, no. 9 (2023): 69–74. http://dx.doi.org/10.25303/2709rjce069074.

Full text

Abstract:

A series of novel trifluoromethyl-thieno[2,3-b] pyridine-2-carboxamide 3a-h and Schiff’s base derivatives 5a-g was prepared starting from 6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carb onitrile 1. Compound 1 on reaction with bromoethyl acetate produced ester derivative 2 on reaction with different amines produced amide derivatives 3. Ester derivative 2 which on reaction with hydrazine hydrate gave hydrazide 4 derivative. Further this compound on reaction with different substituted aromatic aldehydes formed Schiff’s base derivatives 5. All the products 3a-h and 5a-f were screened

APA, Harvard, Vancouver, ISO, and other styles

34

Harnden, MR, and DT Hurst. "The Chemistry of Pyrimidinethiols. III. The Synthesis of Some Substituted Pyrimidinthiols and Some Thiazolo[5,4-D]pyrimidines." Australian Journal of Chemistry 43, no. 1 (1990): 55. http://dx.doi.org/10.1071/ch9900055.

Full text

Abstract:

The preparation of a number of pyrimidinethiols and (substituted) thiopyrimidines has been carried out. The reaction of 5-acetylamino-2-aminopyrimidine-4,6-diol with phosphorus penta -sulfide in pyridine gave 5-amino-2-methylthiazolo[5,4-d]pyrimidine-7-thiol which was used to prepare several additional novel pyrimidine derivatives. Hydrolysis of the 4-carboxymethylthio derivative by using 5M hydrochloric acid gave 2,5-diamino-6-mercaptopyrimidin-4-ol hy -drochloride whilst hydrolysis of 2-methyl-7-methylthiothiazolo[5,4-d]pyrimidin-5-amine gave the corresponding 4-hydroxy derivative. Several 4

APA, Harvard, Vancouver, ISO, and other styles

35

Ismiyati, Nur, Yuli Puspito Rini, Andi Eko Wibowo, and Ratna Asmah Susidarti. "Cytotoxic Activity of 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone on Colon Cancer Cell WiDr." Indonesian Journal of Cancer Chemoprevention 6, no. 1 (2017): 12. http://dx.doi.org/10.14499/indonesianjcanchemoprev6iss1pp12-15.

Full text

Abstract:

Colon cancer is one of the most common death-caused cancer. The high mortality rate indicates that chemotherapy has not overcome cancer disease. Strategies and development of colon cancer treatment should be pursued. Compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone is the 2ʹ,5ʹ-dihydroxychalcone derivative, of which the B ring was substituted with 2-pyridine ring. Chalcone and its derivatives have been reported to have several biological activities, such as cytotoxic, anti-inflammatory, antiHIV, and as a tyrosine kinase inhibitor. The objectives of this research was to determine the

APA, Harvard, Vancouver, ISO, and other styles

36

Holý, Antonín, and Ivan Rosenberg. "Synthesis of isomeric and enantiomeric O-phosphonylmethyl derivatives of 9-(2,3-dihydroxypropyl)adenine." Collection of Czechoslovak Chemical Communications 52, no. 11 (1987): 2775–91. http://dx.doi.org/10.1135/cccc19872775.

Full text

Abstract:

Reaction of 9-(S)-(2,3-dihydroxypropyl)adenine (I) with chloromethanephosphonyl chloride (VII) in pyridine or triethyl phosphate, or with chloromethyl(pyridinio)phosphonate (IX) in pyridine, afforded a mixture of 2'-(IV) and 3'-O-chloromethanephosphonate (V) which were separated on anion exchange resin or alkylsilica gel. Treatment of compounds IV and V with aqueous alkaline hydroxide, followed by deionization, gave 9-(S)-(2-hydroxy-3-phosphonylmethoxypropyl)adenine (VI) and 9-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (III) (HPMPA), respectively. The (R)- and (RS)-forms of III and VI we

APA, Harvard, Vancouver, ISO, and other styles

37

Xu, Bin, Yan Ji, Xueqiong Zhang, Xiaodong Jin, Wenzhong Yang, and Yizhong Chen. "Experimental and theoretical studies on the corrosion inhibition performance of 4-amino-N,N-di-(2-pyridylmethyl)-aniline on mild steel in hydrochloric acid." RSC Advances 5, no. 69 (2015): 56049–59. http://dx.doi.org/10.1039/c5ra09173j.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Amr, Abdel-Galil E. "Synthesis of Some New Linear and Chiral Macrocyclic Pyridine Carbazides as Analgesic and Anticonvulsant Agents." Zeitschrift für Naturforschung B 60, no. 9 (2005): 990–98. http://dx.doi.org/10.1515/znb-2005-0914.

Full text

Abstract:

A series of 2,6-disubstituted pyridine derivatives were prepared from 2,6-diacetylpyridine or 2,6- dicarbonyl pyridine dichloride as starting materials. Reaction of 2,6-diacetylpyridine 1 with hydroxylamine hydrochloride or different aromatic aldehydes afforded the corresponding 2,6-diacetylpyridine dioxime and 2,6-bis-[β -(2-thienyl)acryloyl]pyridine derivatives 2 and 3, respectively. Additionally, N2,N2‘-(pyridine-2,6-dicarbonyl)-L-amino acid hydrazides 5 were prepared starting from 2,6- dicarbonyl pyridine dichloride via the corresponding esters 4. Compound 3 was reacted with hydroxylamine

APA, Harvard, Vancouver, ISO, and other styles

39

Yavari, Issa, Sara Sheikhi, Jamil Sheykhahmadi, Zohreh Taheri, and Mohammad Reza Halvagar. "Ultrasound-Promoted Synthesis of Spirocyclopropanes from Switchable Starting Materials via Azomethine Ylide [3+2]-Cycloaddition." Synthesis 53, no. 12 (2021): 2057–66. http://dx.doi.org/10.1055/a-1370-1884.

Full text

Abstract:

AbstractAn ultrasound-promoted green protocol to access a new series of spirocyclopropanes from indeno[1,2-b]quinoxaline derivatives and azomethine ylides, generated in situ from the iodine-catalyzed reaction of acetophenones as well as of 2-methylquinoline with pyridine in the presence of a base, is described. These transformations proceed via a spirocyclopropanation reaction followed by elimination of pyridine. Clear evidence for the structure of a spirocyclopropane-linked indenoquinoxaline derivative was obtained from single-crystal X-ray analysis. The most important feature of this reactio

APA, Harvard, Vancouver, ISO, and other styles

40

Nassar, Ibrahim F., Wael A. El-Sayed, Tamer I. M. Ragab, Al Shimaa Gamal Shalaby та Ahmed B. M. Mehany. "Design, Synthesis of New Pyridine and Pyrimidine Sugar Compounds as Antagonists Targeting the ERα via Structure-Based Virtual Screening". Mini-Reviews in Medicinal Chemistry 19, № 5 (2019): 395–409. http://dx.doi.org/10.2174/1389557518666180820125210.

Full text

Abstract:

Background: New aryl substituted cyclohepta[b]pyridine and cyclohepta[d]pyrimidine derivatives were synthesized. The sugar hydrazones of the synthesized pyridine and pyrimidine compounds were also prepared. </P><P> Method: In addition, the 1,3,4-oxadiazolyl acyclic C-nucleoside analogs of the pyridine system were prepared. The hemolytic, prebiotic, anticancer and antimicrobial activities of some of the synthesized compounds were also studied. Compounds 10 and 12 showed high activity against MCF-7, HEPG-2 and HCT-116 cell lines with IC50 at range 3.56-8.55 &#181;g/mL. In additio

APA, Harvard, Vancouver, ISO, and other styles

41

Sanad, Sherif M. H., Azza M. Abdel-Fattah, Fawzy A. Attaby, and Mohamed A. A. Elneairy. "Synthesis and characterization of novel bis(pyridine-2(1H)-thiones) and their bis(2-methylsulfanylpyridines) incorporating 2,6-dibromophenoxy moiety." Canadian Journal of Chemistry 97, no. 1 (2019): 53–60. http://dx.doi.org/10.1139/cjc-2017-0721.

Full text

Abstract:

The novel 1,4-bis(2,6-dibromo-4-formylphenoxy)butane (3), prepared from 3,5-dibromobenzaldehyde (1), reacted with different hydrazines 4a–4d and active methylene containing compounds 9a–9d to give the corresponding bis(hydrazones) 5a–5d and bis(cinnamonitriles) 11a–11d, respectively. Both bis(2-cyanoacetic acid hydrazide) derivative 5d and bis(thioacrylamide) derivative 11a were taken as synthetic precursors for the synthesis of the target molecules bis(pyridine-2(1H)-thione) derivative 10 and 13a–13c and their bis(2-methylsulfanylpyridine) derivative 14 and 17a–17c. Another synthetic route wa

APA, Harvard, Vancouver, ISO, and other styles

42

Nong, Xu-Hua, Xiao-Yong Zhang, Xin-Ya Xu, Yun-Lin Sun, and Shu-Hua Qi. "Alkaloids from Xylariaceae sp., a Marine-derived Fungus." Natural Product Communications 9, no. 4 (2014): 1934578X1400900. http://dx.doi.org/10.1177/1934578x1400900407.

Full text

Abstract:

A new pyridine derivative, 5-(2′-hydroxypropyl)pyridin-3-ol (1), with seven known alkaloids, 3-hydroxy-5-methyl-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one (2), penicillenol A1 (3), penicillenol A2 (4), a mixture of quinolactacin A1 (5a) and quinolactacin A2 (5b), and a mixture of quinolactacin C1 (6a) and quinolactacin C2 (6b), were isolated from the culture broth of a marine-derived fungus Xylariaceae sp. SCSGAF0086. Their structures were elucidated by spectroscopic methods. Compound 2 showed weak antimicrobial activity against Bacillus subtilis, and a mixture of 6a and 6b exhibited strong ant

APA, Harvard, Vancouver, ISO, and other styles

43

Alshahrani, Saeed, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, Mar Ríos-Gutiérrez, and Assem Barakat. "Exploring Regio- and Stereoselectivity in [3+2] Cycloaddition: Molecular Electron Density Theory Approach for Novel Spirooxindole-Based Benzimidazole with Pyridine Spacer." Crystals 13, no. 7 (2023): 1085. http://dx.doi.org/10.3390/cryst13071085.

Full text

Abstract:

A new ethylene derivative was synthesized as a precursor for the [3+2] cycloaddition (32CA) reaction to access a novel spirooxindole embodied with benzimidazole with a pyridine spacer. The chalcone derivatives 3a–j is obtained with condensation of the acetyl derivative with aryl aldehydes. The one-pot multi-component reaction of the ethylene derivative, 5-Cl-isatin, and octahydroindole-2-carboxylic acid enables the construction of a highly functionalized quaternary center spirooxindole scaffold in a high chemical yield. A study using the Molecular Electron Density Theory (MEDT) explains the co

APA, Harvard, Vancouver, ISO, and other styles

44

Hammouda, M., A. S. El-Ahl, Y. M. El-Toukhee, and M. A. Metwally. "Reactions of Ketonic Mannich Bases with Malononitrile and Malononitrile dimer." Journal of Chemical Research 2002, no. 2 (2002): 89–94. http://dx.doi.org/10.3184/030823402103171258.

Full text

Abstract:

The reaction of malononitrile with the tertiary Mannich base hydrochloride derived from acetophenone and some related compounds 1, 3, 5 and 7, in piperidine at 50°C afforded the pyrido[1,2-a]pyrimidine derivatives 2, tetrahydronaphthalene derivative 4 substituted quinolines 6 and benzopyran derivatives 8. While the condensation of malononitrile dimer with acetophenone, cyclohexanone and/ or α-tetralone Mannich bases hydrochloride 1, 3 and 9 gave the pyridine, isoquinoline and benzo[f]isoquinoline derivatives 10–12 in moderate to good yield.

APA, Harvard, Vancouver, ISO, and other styles

45

Kwiatkowski, Adam, Erkki Kolehmainen, and Borys Ośmiałowski. "Conformational and Tautomeric Control by Supramolecular Approach in Ureido-N-iso-propyl,N’-4-(3-pyridin-2-one)pyrimidine." Molecules 24, no. 13 (2019): 2491. http://dx.doi.org/10.3390/molecules24132491.

Full text

Abstract:

Ureido-N-iso-propyl,N’-4-(3-pyridin-2-one)pyrimidine (1) and its 2-methoxy pyridine derivative (1Me) has been designed and prepared. The conformational equilibrium in urea moiety and tautomerism in the pyrimidine part have been investigated by variable temperature and 1H NMR titrations as well as DFT quantum chemical calculations. The studied compounds readily associate by triple hydrogen bonding with 2-aminonaphthyridine (A) and/or 2,6-bis(acetylamino)pyridine (B). In 1, the proton is forced to 1,3-tautomeric shift upon stimuli and keeps it position, even when one of the partners in the compl

APA, Harvard, Vancouver, ISO, and other styles

46

Patel, Navin, Sabir Pathan, and Hetal I. Soni. "3,4-Dihydropyrimidin-2(1H)-One Analogues: Microwave irradiated Synthesis with Antimicrobial and Antituberculosis Study." Current Microwave Chemistry 6, no. 1 (2019): 61–70. http://dx.doi.org/10.2174/2213335606666190724093305.

Full text

Abstract:

Background: For rapid and sustainable synthesis, microwave irradiation method is serviceable. This present study deals with the preparation of oxadiazole and pyridine bearing 1,2,3,4- tetrahydro pyrimidine derivatives by microwave irradiation. Objective: The present study aims to carry out rapid synthesis of chloro-acetamides of oxadiazoles of Biginelli product and amino cyano derivative of pyridine by microwave-assisted heating. Our efforts are focused on the introduction of chemical diversity in the molecular framework in order to synthesize pharmacologically interesting compounds. Methods::

APA, Harvard, Vancouver, ISO, and other styles

47

Bender, Tobias, and Paultheo von Zezschwitz. "Total Synthesis of 4-Acetyl-1,3-Dihydroimidazo[4,5-c]Pyridin-2-One, a New Microbial Metabolite from a Streptomyces Species." Natural Product Communications 4, no. 7 (2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400719.

Full text

Abstract:

The structure of a new secondary metabolite from Streptomyces sp. was determined as 4-acetyl-1,3-dihydroimidazo[4,5-c]pyridin-2-one by synthesis of the natural product itself and of the regioisomeric 7-acetylimidazo[4,5-b]pyridine derivative. The former compound was prepared, in 28% overall yield, in a sequence of nitration, reduction, condensation, and Stille reaction of 4-aminopyridine, while the regioisomer was obtained in 5% overall yield by amination, nitration, reduction, condensation, and oxidation of 4-ethylpyridine.

APA, Harvard, Vancouver, ISO, and other styles

48

Ahmed, H. Shamroukh, E. Rashad Aymn, T. Gaballah Samir, A. A. Osman Dalia, I. Hashem Ahmed, and M. E. Abdel-Megeid Farouk. "Synthesis of some N-Acyclic Pyrazolopyrimidine Nucleosides and Pyrazolotriazolopyrimidines." Chemistry Research Journal 5, no. 5 (2020): 89–96. https://doi.org/10.5281/zenodo.13144550.

Full text

Abstract:

<strong>Abstract </strong>Pyrazolo[3,4-<em>d</em>]pyrimidin-4-one derivative <strong>1</strong> was used as a key compound for the preparation of some <em>N</em>-acyclic nucleosides of pyrazolo[3,4-<em>d</em>]pyrimidines <strong>2-5</strong>. Also, the synthesis and structure characterization of pyrazolo[3,4-<em>d</em>]pyrimidin-6-yl-hydrazine derivative <strong>6 </strong>was reported as a key compound for the preparation of pyrazolotriazolopyrimidine derivatives <strong>7</strong>-<strong>9 </strong>under different suitable reaction conditions. Cyclization of the hydrazone derivatives <stron

APA, Harvard, Vancouver, ISO, and other styles

49

Thomas, Mallory E., Lynn D. Schmitt, and Alistair J. Lees. "An Investigation into Anion Sensing of the Molecular Aggregate of 4-(Pyrrol-1-yl)pyridine and Its Derivatives." Molecules 29, no. 23 (2024): 5692. https://doi.org/10.3390/molecules29235692.

Full text

Abstract:

Recently, 4-(pyrrol-1-yl)pyridine has been found to act as a supramolecular chemodosimeter, sensing nitrite ions in an aqueous solution with naked eye detection and a low limit of detection of 0.330 ppm. This work explores the anion-sensing properties of related derivatives, 4-(2,5-dimethyl-pyrrol-1-yl)pyridine and 4-(2,4-dimethyl-pyrrol-1-yl)pyridine, and provides a comparison with the parent compound. These molecules are determined to be effective sensors for nitrite ions with limits of detection of 1.06 ppm and 1.05 ppm, respectively. The high sensitivity and selectivity to nitrite remain e

APA, Harvard, Vancouver, ISO, and other styles

50

Sati, Bhawana, Alka Tyagi, and Anurag. "Newer Coumarin-linked Heterocyclic Hybrids: Design, Synthesis and Biological Assessment as Possible Anti-Alzheimer Drugs." Asian Journal of Chemistry 37, no. 3 (2025): 552–60. https://doi.org/10.14233/ajchem.2025.33211.

Full text

Abstract:

As newer acetyl cholinesterase antagonists which could be effective in Alzheimer’s disease management, derivatives of 4-hydroxycoumarin were prepared. The 2-((2-oxo-2H-chromen-4-yl)oxy)-N-(pyridin-3-yl)acetamide derivative (4c) and 2-((2-oxo-2H-chromen-4-yl)oxy)-N-(pyridin-4-yl)acetamide (4d) showed the maximum AChE inhibition effect (IC50 = 0.957 ± 0.014 and 1.377 ± 0.018 mM, respectively) among the 16 coumarin-derived compounds evaluated against human acetylcholinesterase (hAChE). PHE 338 and HID 447 are responsible for ligand identification and trafficking by creating a polar π-π interactio

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!