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Dissertations / Theses on the topic 'Pyridine. Heterocyclic chemistry'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Walji, Dhiran. "A radical approach towards the synthesis of novel pyridine and pyrimidine based heterocycles." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=62164.

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2

Dincoflaz, Yasemin. "The Synthesis Of 6- And 7- Membered Heterocyclic Ring Systems Fused To Pyridine Ring." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615579/index.pdf.

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The synthesis of the nitrogen containing heterocyclic compounds is one of the leading research areas throughout the organic chemistry due to their significant activities in biological systems. Among the various biologically active molecules, pyridine-fused ring systems are of prime importance on the grounds of their proven clinical roles. The coupling reactions with 6-membered heterocyclic compounds and diazepines gave rise to new pharmalogical compounds in recent years. Therefore, our object was the synthesis of pyridine-fused 6- and 7-membered heterocycles. Starting from bromopyridine, two d

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3

Tittle, James Alfred. "Ab Initio Studies of High Temperature Pyrolysis Mechanisms in Heterocyclic Nitrogen-Containing Compounds." Digital Commons @ East Tennessee State University, 2000. https://dc.etsu.edu/etd/21.

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The decomposition mechanisms of various coal constituents undergoing pyrolysis are of great concern in environmental circles (especially those coal constituents containing nitrogen). Most methods of burning coal that are efficient involve doing so at high temperatures. This invariably results in a large portion of non-combusting coal being heated to high temperatures also causing pyrolysis of the original coal constituents. The end result of such pyrolysis is the production of a number of noxious gaseous products. If we are to design methods of reducing the amount of toxins that are produced f

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4

Byrichetti, Kiranmai. "Synthesis and Structure of a Substituted Pyridazine." TopSCHOLAR®, 2011. http://digitalcommons.wku.edu/theses/1080.

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Pyridazines are heterocyclic compounds with an N-N bond in their ring structure. Heterocyclic aromatic compounds are of great interest as a result of their novel properties and commercial applications. Our current research is focused on the potential role of pyridazines in next generation electronic devices that utilize organics as the semiconducting material. The synthesis of 5, 6-fused ring pyridazines beginning from fulvenes (Scheme 1) is described herein. These fused heterocycles will serve as synthetic models and building blocks for potential organic or organometallic conducting polymers.

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5

Lansakara, Ashabha Indrashika. "Intramolecular cyclizations of alkyl pyridines & alkylidene dihydropyridines as synthetic intermediates toward synthesis of bis(piperidine) alkaloids." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/2105.

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Nature provides fascinating and complicated molecular structures which offer synthetic organic chemists amazing opportunities for the design of new strategies for natural product synthesis. Among these, nitrogen containing aza-heterocycles are of unparalleled importance in natural product, bioorganic, and medicinal chemistry. Pyridine and its derivatives in particular are the most common aza-heterocycles encountered in natural products, medicinal and materials chemistry. Pyridine derivatives also serve as precursors to fun

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6

Raux, Elizabeth A. "Synthesis of Selective 5-HT6 and 5-HT7 Receptor Antagonists." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/chemistry_theses/32.

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The development of novel selective 5-HT6 and 5-HT7 receptor antagonists is an ever-growing area of interest among medicinal chemists. The potential of developing a therapeutic agent useful as an antipsychotic or antidepressant, as well as the possibility to develop a drug for Alzheimer’s disease and obesity has led to an increase in synthesis of possible lead compounds. The synthesis of unfused biheteroaryl derivatives is described within. The derivatives have been evaluated for binding affinity at 5-HT2A, 5-HT6 and 5-HT7 receptors. The most potent 5-HT6 receptor antagonists include a benzene

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7

Fernandez, Beatriz. "New functionalisation chemistry of 2- and 4-pyridones and related heterocycles." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/21685.

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New methodology for the synthesis of several 4H-pyrido[1,2-a]pyrimidin-4-ones has been developed from commercially available 2-aminopyridines and β-oxo esters catalysed by Montmorillonite under solvent-free conditions in good yields. This methodology was expanded for the synthesis of 4H-pyrimido[1,2-a]pyrimidin-4-one derivatives from 2-aminopyrimidine and different β-keto esters. The new methodology for the synthesis of N-alkylated 6-methyl 2-pyridones and N-alkylated 2-methyl 4-pyridones, from commercially available starting materials was developed. For the synthesis of N-alkylated 6-methyl 2

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8

Pchalek, Karin Chemistry Faculty of Science UNSW. "Design and synthesis of new ligands and heterocycles from activated indoles." Awarded by:University of New South Wales. School of Chemistry, 2004. http://handle.unsw.edu.au/1959.4/20584.

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For the purpose of incorporating indoles into organometallic complexes for catalysis, as well as in the generation of new heterocyclic systems, various reactions have been carried out at C2, C6 and C7 of the indole system. In order to achieve this, 3-substituted 4,6-dimethoxyindoles and 6-hydroxy- 4-methoxyindoles were necessary as starting materials. Consequently, a lithium-bromide-templated one-pot procedure for the synthesis of some 3-substituted 4,6-dimethoxyindoles and a selective demethylation procedure for 3-substituted 6-hydroxy-4-methoxyindoles were developed. Various kinds of novel

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9

Joshi, Madhur Satish. "Elaboration of azine and azole anhydrobases via intra- and intermolecular cyclizations for heterocycle construction." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5788.

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Aza-heterocycles such as pyridines, imidazoles, piperidines, etc. are ubiquitous structural motifs found in various natural products and pharmacologically active compounds. Thus, they are of unparalleled importance to synthetic, medicinal, and materials chemists. Despite their structural significance, organic transformations available for the functionalization of these heterocycles remain underdeveloped. The development of several synthetic methods to construct aza-heterocyclic building blocks is described in this thesis, which, in turn, should facilitate the assembly of more elaborate framewo

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10

Greenwood, Jeremy Robert. "Pyridazinediones and amino acid receptors: theoretical studies, design, synthesis, and evaluation of novel analogues." University of Sydney, Department of Pharmacology, 1999. http://hdl.handle.net/2123/394.

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http://www.pharmacol.usyd.edu.au/thesis This thesis is primarily concerned with a class of chemical compounds known as pyridazinediones, being 6-membered aromatic rings containing two adjacent nitrogen atoms (pyridazine), doubly substituted with oxygen. In particular, the work focuses on pyridazine-3,6-diones, derivatives of maleic hydrazide (1). Understanding of the chemistry of these compounds is extended, using theoretical and synthetic techniques. This thesis is also concerned with two very important classes of receptors which bind amino acids in the brain: firstly, the inhibitory GABA re

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11

Abou, Hamdan Hussein. "Synthèse de nouveaux agents anticancéreux." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF012.

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Les cancers représentent un problème majeur de santé public d'où la nécessité de rechercher de nouvelles classes de médicaments. Parmi les pistes pour développer de nouveaux traitements, deux ont retenu notre attention et celle de nos collaborateurs : la modulation de l’épissage par des composés comme le NVS-SM2, et l’inhibition de l’oncogène KRAS par des dérivés de produits naturels, les flavaglines. Dans ce contexte, nous avons développé la première synthèse robuste du NVS-SM2, qui peut satisfaire la demande globale de cet agent pour examiner en détail son potentiel thérapeutique dans différ

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12

Chartoire, Anthony. "Synthèse et fonctionnalisation des furo[3,2-b]- et [2,3-c]pyridines par voie organométallique." Thesis, Nancy 1, 2010. http://www.theses.fr/2010NAN10081/document.

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Le travail décrit dans ce mémoire concerne l'étude de la métallation régiosélective de deux bicycles fusionnés complexes : les furo[3,2-b]- et [2,3-c]pyridines. L'influence de la nature du système basique sur le cours de la réaction et sur la régiosélectivité de la lithiation a été étudiée avec différentes bases : n-BuLi, LTMP, LDA et [n-BuLi/LiDMAE]. D'un point de vue fondamental, cette étude nous a permis d'établir quelques règles pour la fonctionnalisation des hétérocycles complexes, ce qui nous a conduit à l'obtention efficace et rapide d'une vaste chimiothèque de furo[3,2-b]- et [2,3-c]py

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13

Halut, Desportes Sabine. "Etude de complexes du MG2+ avec le méthanol et la pyridine par diffraction des rayons X et spectroscopie vibrationnelle." Paris 6, 1986. http://www.theses.fr/1986PA066408.

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Synthèse et caractérisation de differents complexes solides. Structures de MG CH3OH6 BR::(2), (MGPY::(4)CL::(2)), (MGPY::(4)BR::(2))PY::(2) (MG(H::(2)O)::(4)PY::(2))CL::(2), (MG(H::(2)O)::(3)PY::(3)) BR::(2)PY::(2) ET (MG(H::(2)O)::(2)PY::(4))I::(2)PY::(2). Analyse des spectres IR de M(ROH)::(6) X::(2), M(ROH)::(4)X::(2) (AVEC M = MG,CA; R = CH::(3),C::(2)H::(5); X = CL,BR) ET DE MG(PY)::(4) CL::(2) ET M(PY)::(4)X::(2)PY::(2) (M = CA,MG)

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14

Jasselin-Hinschberger, Adeline. "Polyfonctionnalisations sélectives par voie organométallique en série furopyridines : développement de procédés séquentiels et "one-pot" originaux." Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0163/document.

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Le travail décrit dans ce mémoire concerne l'étude de la métallation régiosélective d’un bicycle fusionné: la furo[3,2-B]pyridine. L'influence de la nature du système basique sur le cours de la réaction et sur la régiosélectivité de la lithiation a été étudiée avec différentes bases : n-BuLi, LiTMP, LiDA et [n-BuLi/LiDMAE]. D'un point de vue fondamental, cette étude nous a permis d'établir quelques règles pour la fonctionnalisation des furopyidines, ce qui nous a conduit à l'obtention efficace et rapide d'une vaste chimiothèque de furo[3,2-B]pyridines polyfonctionnalisées et refonctionnalisabl

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15

"Synthesis of novel benzimidazole derivatives and their platinum (II) complexes." Thesis, 2010. http://hdl.handle.net/10413/2614.

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Benzimidazole and its derivatives have attracted many organic chemists due to their interesting biological activities. These include activities against viruses such as, HIV, RNA, herpes (HSV-1), influenza, and cytomegalovirus (HCMV); antimicrobial and antitumor activities. Even though a lot of research has been conducted on the synthesis of benzimidazoles, factors such as, drug resistance present a need for synthesis of more structural analogues of these compounds. In chapter three, the synthesis of 2-aryl-1Hbenzimidazoles (46a-c) and 2-aryl-1-arylmethyl-1H-benzimidazoles (49a-d) is described.

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16

Cai, Cuifang. "The preparation of heterocycles by [2+2+2] cyclization and inverse electron demand Dels-Alder reactions of arynes with 1,2,4-triazines." Thesis, 2017. https://hdl.handle.net/2144/27298.

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Transition metal mediated [2 + 2 + 2] cyclizations have been well researched over the past several years. As a well-developed methodology, [2 + 2 + 2] chemistry has been employed as a major pathway to various carbo- and heterocyclic synthetic targets. Numerous transition metals have been applied as catalysts for these cyclizations. Previous work in our group developed cobalt(I) catalyzed inter- and intramolecular [2 + 2 + 2] cyclizations of two alkynes and a nitrile, leading to the preparation of tetrahydro-naphthyridines. Pyridazines could be generated if the cyclization could be accomplished

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17

Pelletier, Guillaume. "Synthèse stéréosélective de pipéridines et activation électrophile chimiosélective d’amides en présence de dérivés de la pyridine." Thèse, 2013. http://hdl.handle.net/1866/10512.

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L’importance des produits naturels dans le développement de nouveaux médicaments est indéniable. Malheureusement, l’isolation et la purification de ces produits de leurs sources naturelles procure normalement de très faibles quantités de molécules biologiquement actives. Ce problème a grandement limité l’accès à des études biologiques approfondies et/ou à une distribution sur une grande échelle du composé actif. Par exemple, la famille des pipéridines contient plusieurs composés bioactifs isolés de sources naturelles en très faible quantité (de l’ordre du milligramme). Pour pallier à ce problè

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18

Régnier, Sophie. "Synthèse efficace d'hétérocycles azotés par activation d'amides engendrée par l'anhydride trifluorométhanesulfonique." Thèse, 2016. http://hdl.handle.net/1866/18658.

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Les hétérocycles azotés sont d’une importance considérable dans le domaine pharmaceutique. En effet, ces composés se retrouvent dans de nombreuses structures bioactives brevetées dans les dernières années. Malgré l’utilité de ces motifs, leur synthèse nécessite souvent plusieurs étapes ou encore l’utilisation de matériaux de départ fonctionnalisés. Le présent mémoire décrit de nouvelles méthodologies pour accéder à ces structures de façon douce, chimiosélective et efficace par l’activation d’amides avec l’anhydride trifluorométhanesulfonique. Dans un premier temps, une méthode en deux étapes

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