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Dissertations / Theses on the topic 'Pyridine nucleotides'

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1

O'Reilly, Michael Terrence Stewart. "Pyridine nucleotide metabolism by porcine haemophili." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=73973.

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2

Graham, François. "Regulation of 5-oxo-ETE synthesis by pyridine nucleotides in aging neutrophils." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116087.

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Neutrophils (polymorphonuclear leukocytes) are short lived granulocytes that playa primordial role in host innate defense against invading pathogens. Freshly isolated neutrophils spontaneously undergo apoptosis when cultured, which is associated with oxidative stress. We found that there is a dramatic shift in the metabolism of the 5-lipoxygenase product 5-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) from its biologically inactive o-oxidation product in freshly isolated neutrophils to the potent granulocyte chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in neutrophils cu
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3

Kirvelaitytė, Dovilė. "Hipertermijos poveikis adenino ir piridino nukleotidų koncentracijai kepenų ląstelėse ir audinyje." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100614_095031-16530.

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Šilumos taikymas įvairioms ligoms gydyti jau buvo naudojamas senovės Egipto, Graikijos, Romos civilizacijose daugiau kaip prieš 2000 m. pr. Šiuo metu hipertermija plačiai taikoma visame pasaulyje gydant vėžį, nes tai pigus ir patogus metodas turintis mažą šalutinį poveikį. Mokslininkai nustatė, kad vėžinės ląstelės greičiau žūsta esant aukštesnei už fiziologinę (41-45°C) temperatūrai, todėl hipertermija, derinama su kitais vėžio gydymo metodais (radioterapija, chemoterapija, imunoterapija ir chirurgija), tampa efektyvesniu metodu. Kadangi yra mažai žinoma apie hipertermijos poveikio mechaniz
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4

Djerada, Zoubir. "Récepteurs P2Y et Cardioprotection : implication du récepteur P2Y11-like dans le préconditionnement pharmacologique induit par le NAADP extracellulaire." Thesis, Reims, 2013. http://www.theses.fr/2013REIMM201.

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L’infarctus du myocarde (IC) représente plus de 15 % de la mortalité mondiale liés aux maladies cardiovasculaires (MC). En absence d’une rapide reperfusion des coronaires occluses, aucune intervention thérapeutique n’est capable de limiter les effets délétères de l’IC. Un des moyens les plus efficaces de la cardioprotection, étudié en recherche, est le préconditionnement cardiaque ischémique (PCI). L’adénosine libérée au cours du PCI active via ces récepteurs P1 les voies de cardioprotection. Des études mettent en évidence également l’implication des purinorécepteurs P2Y dans la cardioprotecti
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5

Buckley, Patrick Anthony. "Structural studies on pyridine nucleotide dependent enzymes." Thesis, University of Sheffield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392543.

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6

Wilson, Heather Louise. "Regulation of calcium mobilisation by pyridine nucleotide metabolites." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298417.

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7

Boonstra, Birgitte. "A study of bacterial soluble pyridine nucleotide transhydrogenases." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621214.

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8

Denicola-Seoane, Ana. "Studies on pyridine nucleotide-dependent processes in Haemophilus influenzae." Diss., Virginia Polytechnic Institute and State University, 1989. http://hdl.handle.net/10919/54514.

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Haemophilus influenzae and related species have a unique requirement for externally-provided NAD; therefore, several pyridine nucleotide-requiring enzymes become important for the survival of these pathogens. Haemophilus influenzae ATP:NMN adenylyltransferase was partially purified 15-fold with a 27% yield using dye affinity chromatography. Affinity chromatography was also used to purify NAD kinase from Haemophilus influenzae, 18-fold with a 32% yield. Substrate specificity studies of these enzymes demonstrated the enzymes to function with 3-acetylpyridine analogs of their respective substrat
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9

Clarke, David Morgan. "Pyridine nucleotide transhydrogenase of Escherichia coli: nucleotide sequence of the pnt gene and characterization of the enzyme complex." Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/27044.

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Based on the rationale that Escherichia coli cells harboring plasmids containing the pnt gene would contain elevated levels of enzyme, three clones were isolated bearing the transhydrogenase gene from the Clarke and Carbon colony bank. The three plasmids were subjected to restriction endonuclease analysis. A 10.4-kilobase restriction fragment which overlapped all three plasmids was cloned into pUC13. Examination of several deletion derivatives of the resulting plasmids and subsequent treatment with exonuclease BAL31 revealed that enhanced transhydrogenase expression was localized within a 3.05
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10

Breidenbach, Carl R. "Phospholipid Dependency of Membrane-Associated Pyridine Nucleotide-Utilizing and Succinate Dehydrogenase Activities of Adult Hymenolepis Diminuta (Cestoda) and Ascaris Suum (Nematoda)." Bowling Green State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1343921911.

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11

Shuler, Elizabeth. "The effects of flavonoids on mitochondrial membrane-associated reduced pyridine nucleotide-utilizing systems of adult Hymenolepis diminuta (cestoda) and Ascaris suum (nematoda)." Bowling Green State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1367950138.

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12

Dammer, Eric B. "Chromatin, SF-1, and CtBP structural and post-translational modifications induced by ACTH/cAMP accelerate CYP17 transcription rate." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26595.

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Thesis (Ph.D)--Biology, Georgia Institute of Technology, 2009.<br>Committee Chair: Marion B. Sewer; Committee Member: Alfred H. Merrill, Jr.; Committee Member: Donald F. Doyle; Committee Member: Dr. Edward T. Morgan; Committee Member: Kirill S. Lobachev. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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13

Glavas, Natalie Ann. "Structural and functional studies of the pyridine nucleotide transhydrogenase of Escherichia coli." Thesis, 1994. http://hdl.handle.net/2429/7065.

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The genes for the E. coli transhydrogenase enzyme have been cloned and sequenced in this lab and overexpressed in the membranes of E. coli (Clarke et al., 1986, Eur. J. Biochem. 158, 647-653). The E. coli transhydrogenase was found to consist of an α subunit (54588 Da) and a β subunit (48691 Da) arranged as an α₂β₂ dimer (Hou et al., 1990, Biochim. Biophys. Acta 1018, 61-66). The transhydrogenase enzyme was studied with respect to topology, location of the active sites, mechanism of proton pumping and mechanism of hydride transfer. The transhydrogenase was purified from E. coli membranes
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14

Howitt, Crispin Alexander. "Pyridine nucleotide dehydrogenases in the cyanobacterium Anabaena PCC 7120 and the chloroplasts of higher plants." Phd thesis, 1995. http://hdl.handle.net/1885/143076.

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15

Li, Zhiqun. "Properties of NadV / NatV proteins in a pyridine nucleotide (NAD⁺) scavenging system encoded by vibriophage KVP40." 2004. http://www.lib.ncsu.edu/theses/available/etd-06292004-210411/unrestricted/etd.pdf.

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