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Journal articles on the topic 'Pyridinium compounds – Derivatives (Chemicals)'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

El Kharrat, Salem, Philippe Laurent, Laurent Boiteau, and Hubert Blancou. "Novel Synthesis of Substituted 2-Trifluoromethyl and 2-Perfluoroalkyl N-Arylpyridinium Compounds—Mechanistic Insights." Molecules 24, no. 12 (2019): 2328. http://dx.doi.org/10.3390/molecules24122328.

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We report a new one-pot synthesis of 2-trifluoromethylated/2-perfluoroalkylated N-aryl-substituted pyridiniums, 5,6,7,8-tetrahydroquinoliniums and 6,7,8,9-tetrahydro-5H-cyclohepta[b]-pyridinium compounds starting from an activated β-dicarbonyl analogue (here a perfluoro-alkylated gem-iodoacetoxy derivative), an aromatic amine and a (cyclic or acyclic) ketone. The key step of this multicomponent reaction, involves the formation of a 3-perfluoroalkyl-N,N’-diaryl-1,5-diazapentadiene intermediate, various examples of which were isolated and characterized for the first time, together with investiga

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Wenska, Grazyna, Bohdan Skalski, Stefan Paszyc, and Zofia Gdaniec. "Photochemistry of N-(pyrimidin-2-one-4-yl)pyridinium derivatives. The ring contraction of pyrimidinone into imidazolinone." Canadian Journal of Chemistry 73, no. 12 (1995): 2178–84. http://dx.doi.org/10.1139/v95-270.

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Photochemical reactions (λ > 300 nm) of N-(1-methylpyrimidin-2-one)-and N-(1,5-dimethyl-pyrimidin-2-one)pyridinium chlorides were studied in deoxygenated aqueous solution at various pH's. Only the former compound was found to be reactive under these conditions to give pyrimidine ring contraction photoproducts 1-methyl-4-imidazolin-2-one and 1-methyl-4-imidazolin-2-one-5-carboxyaldehyde, with pH-dependent chemical yields. The photochemical pyrimidine ring contraction reaction does not occur for other photochemically reactive pyrimidin-2-ones bearing 3-methylimidazolium-1,1,2,4-triazol-1-yl,

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3

Montes-González, Ingrid, Ambar M. Alsina-Sánchez, Juan C. Aponte-Santini, Sara M. Delgado-Rivera, and Geraldo L. Durán-Camacho. "Perspectives of ferrocenyl chalcones: synthetic scaffolds toward biomedical and materials science applications." Pure and Applied Chemistry 91, no. 4 (2019): 653–69. http://dx.doi.org/10.1515/pac-2018-0802.

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Abstract Ferrocene and its derivatives constitute versatile and interesting scaffolds for the global chemical enterprise due to its multiple applications that range from biomedical to materials science. Ferrocenyl derivatives are the leading compounds in our research for the syntheses and characterization as well as their potential biological applications. Among them, our recent focus has been in ferrocenyl chalcones as a framework for further derivatization. The proposed modifications consist on the incorporation of heterocyclic moieties into the ferrocenyl chalcone core. This can be afforded

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4

Freitas, Emanuelle Dantas, Celso Fidelis Moura Jr., Jonas Kerwald, and Marisa Masumi Beppu. "An Overview of Current Knowledge on the Properties, Synthesis and Applications of Quaternary Chitosan Derivatives." Polymers 12, no. 12 (2020): 2878. http://dx.doi.org/10.3390/polym12122878.

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Chitosan, a chitin-derivative polysaccharide, known for its non-toxicity, biocompatibility and biodegradability, presents limited applications due to its low solubility in neutral or basic pH medium. Quaternization stands out as an alternative to modify this natural polymer, aiming to improve its solubility over a wide pH range and, consequently, expand its range of applications. Quaternization occurs by introducing a quaternary ammonium moiety onto or outside the chitosan backbone, via chemical reactions with primary amino and hydroxyl groups, under vast experimental conditions. The oldest an

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5

Flieger, Jolanta, and Michał Flieger. "Ionic Liquids Toxicity—Benefits and Threats." International Journal of Molecular Sciences 21, no. 17 (2020): 6267. http://dx.doi.org/10.3390/ijms21176267.

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Ionic liquids (ILs) are solvents with salt structures. Typically, they contain organic cations (ammonium, imidazolium, pyridinium, piperidinium or pyrrolidinium), and halogen, fluorinated or organic anions. While ILs are considered to be environmentally-friendly compounds, only a few reasons support this claim. This is because of high thermal stability, and negligible pressure at room temperature which makes them non-volatile, therefore preventing the release of ILs into the atmosphere. The expansion of the range of applications of ILs in many chemical industry fields has led to a growing thre

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6

Armand, Joseph, Line Boulares, Christian Bellec, and Jean Pinson. "Preparation, chemical and electrochemical reduction of pyrido[2,3-b]quinoxalines and pyrido[3,4-b]quinoxalines." Canadian Journal of Chemistry 66, no. 6 (1988): 1500–1505. http://dx.doi.org/10.1139/v88-242.

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The reaction of 2,3-diaminopyridine with the dimeric 4,5-dimethylcyclohexa-3,5-dien-1,2-dione gives 7,8-dimethylpyrido[2,3-b]quinoxaline, 1, in good yields; in the same way 3,4-diaminopyridine gives the 7,8-dimethylpyrido[3,4-b]quinoxaline 2. The electrochemical reduction of 1 and 2 in hydroorganic medium gives the 5,10-dihydro compounds 6 and 7; 1 and 2 present a single 2e− polarographic wave, in contrast to phenazine which shows two monoelectronic waves. The catalytic hydrogenation of 1 and 2 gives 6 and 7 and does not involve the pyridinic ring as in the case of pyridopyrazines. AlLiH4 does

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7

Cychon, Christine, Ellen Lichte, and Matthias Köck. "The marine sponge Agelas citrina as a source of the new pyrrole–imidazole alkaloids citrinamines A–D and N-methylagelongine." Beilstein Journal of Organic Chemistry 11 (October 29, 2015): 2029–37. http://dx.doi.org/10.3762/bjoc.11.220.

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The chemical investigation of the Caribbean sponge Agelas citrina revealed four new pyrrole–imidazole alkaloids (PIAs), the citrinamines A–D (1–4) and the bromopyrrole alkaloid N-methylagelongine (5). All citrinamines are dimers of hymenidin (6) which was also isolated from this sponge as the major metabolite. Citrinamines A (1) and B (2) are derivatives of the PIA dimer mauritiamine (7), whereas citrinamine C (3) is derived from the PIA dimer nagelamide B (8). Citrinamine D (4) shows an uncommon linkage between the imidazole rings of both monomeric units as it is only observed in the benzocyc

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8

Agbodan, Kokou Agbékonyi, Oudjaniyobi Simalou, Gneiny Whad Tchani, and Koffi Jondo. "Etude de l’influence de la basicité sur l’enthalpie de réaction des sels N-méthoxycarbonyl-(oxy)-pyridiniums." International Journal of Biological and Chemical Sciences 14, no. 4 (2020): 1489–98. http://dx.doi.org/10.4314/ijbcs.v14i4.26.

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Les hétérocycles sont importants, aussi bien dans les domaines biologique, médicinal et thérapeutique (vitamines, hormones, antibiotiques, etc), que dans le secteur industriel et technologique (inhibiteurs de corrosion, colorants, agents stabilisants, pesticides, herbicides. Les chloroformiates ou chlorocarbonates sont les esters dérivés de l’acide chloroformique. La chimie des N-oxydes hétérocycliques (pyridine et N-oxydes) a connu un important développement au cours des dernières années. L’objectif principal du présent travail est l’étude de l’action du métoxycarbonylchloride sur la pyridine

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9

Althagbi, Hanan I., Walied M. Alarif, Khalid O. Al-Footy, and Ahmed Abdel-Lateff. "Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity." Marine Drugs 18, no. 7 (2020): 368. http://dx.doi.org/10.3390/md18070368.

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The curiosity and attention that researchers have devoted to alkaloids are due to their bioactivities, structural diversity, and intriguing chemistry. Marine-derived macrocyclic alkaloids (MDMAs) are considered to be a potential source of drugs. Trabectedin, a tetrahydroisoquinoline derivative, has been approved for the treatment of metastatic soft tissue sarcoma and ovarian cancers. MDMAs displayed potent activities that enabled them to be used as anticancer, anti-invasion, antimalarial, antiplasmodial, and antimicrobial. This review presents the reported chemical structures, biological activ

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10

Urban, Jiří, and Jiří Volke. "1,2,4,6-Substituted Pyridinium Derivatives-Synthesis and Properties." Collection of Czechoslovak Chemical Communications 59, no. 11 (1994): 2545–61. http://dx.doi.org/10.1135/cccc19942545.

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In relation to the investigation of their electrochemical properties we prepared 24 pyridinium derivatives (I, IV, V, VI, VII) with alkyl and aryl substituents in positions 1, 2, 4 and 6, and 19 derivatives with two pyridinium nuclei (II, III, VIII, IX, X) connected by an aliphatic or an aromatic chain. All the compounds were prepared from the corresponding pyrylium derivatives by reacting them with primary amines. The pyrylium derivatives were synthesized by aldolization and acylation followed by cyclization leading to a heteroaromatic pyrylium system. In nucleophilic reactions with amines, t

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11

Gómez-Pérez, Verónica, José Ignacio Manzano, Raquel García-Hernández, Santiago Castanys, Joaquín M. Campos Rosa, and Francisco Gamarro. "4-Amino Bis-Pyridinium Derivatives as Novel Antileishmanial Agents." Antimicrobial Agents and Chemotherapy 58, no. 7 (2014): 4103–12. http://dx.doi.org/10.1128/aac.02481-13.

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ABSTRACTThe antileishmanial activity of a series of bis-pyridinium derivatives that are analogues of pentamidine have been investigated, and all compounds assayed were found to display activity against promastigotes and intracellular amastigotes ofLeishmania donovaniandLeishmania major, with 50% effective concentrations (EC50s) lower than 1 μM in most cases. The majority of compounds showed similar behavior in bothLeishmaniaspecies, being slightly more active againstL. majoramastigotes. However, compound VGP-106 {1,1′-(biphenyl-4,4′-diylmethylene)bis[4-(4-bromo-N-methylanilino)pyridinium] dibr

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12

Foye, William O., Robert W. Jones, Pallab K. Ghoshal, and Bijan Almassian. "Antiradiation compounds. 20. 1-Methylquinolinium(and pyridinium)-2-dithioacetic acid derivatives." Journal of Medicinal Chemistry 30, no. 1 (1987): 57–62. http://dx.doi.org/10.1021/jm00384a010.

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13

Moosavi-Zare, Ahmad Reza, Mohammad Ali Zolfigol, Rasoul Salehi-Moratab, and Ehsan Noroozizadeh. "Synthesis of spiropyran derivatives over 1-(carboxymethyl) pyridinium iodide as nanostructured pyridinium salt under aqueous media." Canadian Journal of Chemistry 95, no. 2 (2017): 194–98. http://dx.doi.org/10.1139/cjc-2016-0374.

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In this work, acetic acid functionalized pyridinium salt, namely 1-(carboxymethyl)pyridinium iodide {[cmpy]I}, has been applied as reusable nanostructured catalyst for green, simple and efficient preparation of spiropyrans by the one-pot domino Knoevenagel–Michael–cyclization reaction of isatin derivatives or acenaphthenquinone, with malononitrile, and 1,3-dicarbonyl compounds under aqueous media. Moreover, 1H and 13C NMR, mass, CHN analysis, Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), thermal gravimetric analysis (TGA), differential thermal gravimetric

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14

Mohamed, Nehal Farouk, Mohamed Ibrahim Abdul Mutalib, Mohammad Azmi Bustam, Jean Marc Leveque, and Mohanad El-Harabawi. "Ecotoxicity of Pyridinium Based Ionic Liquids: A Review." Applied Mechanics and Materials 625 (September 2014): 152–55. http://dx.doi.org/10.4028/www.scientific.net/amm.625.152.

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Ionic Liquids (ILs) are an exciting class of compounds with unique properties that make them attractive for industrial applications. Pyridinium-based ILs have been used in many applications, such as organic synthesis, electrochemical applications, biocatalysis, and polymerization. Although intensive information and data regarding to the physical and thermodynamic properties of ILs have been reported and continuously published, only limited data with regards to the toxicity and ecotoxicity of ILs were reported. Toxicity tests are conducted against many aquatic organisms such as: Guppy fish, Gol

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15

Yu, Tan-Lai, Guo-Xing Wu, Mei Xue, Zhong-Hui Wang, and Yun-Long Fu. "Five monocyclic pyridinium derivative based halo-argentate/cuprate hybrids or iodide salts: influence of composition on photochromic behaviors." Dalton Transactions 47, no. 35 (2018): 12172–80. http://dx.doi.org/10.1039/c8dt02574f.

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16

Czaja, Kornelia, Jacek Kujawski, Radosław Kujawski, and Marek K. Bernard. "DFT investigations on arylsulphonyl pyrazole derivatives as potential ligands of selected kinases." Open Chemistry 18, no. 1 (2020): 857–73. http://dx.doi.org/10.1515/chem-2020-0135.

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AbstractUsing the density functional theory (DFT) formalism, we have investigated the properties of some arylsulphonyl indazole derivatives that we studied previously for their biological activity and susceptibility to interactions of azoles. This study includes the following physicochemical properties of these derivatives: electronegativity and polarisability (Mulliken charges, adjusted charge partitioning, and iterative-adjusted charge partitioning approaches); free energy of solvation (solvation model based on density model and M062X functional); highest occupied molecular orbital (HOMO)–lo

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17

Belguedj, Roumaissa, Sofiane Bouacida, Hocine Merazig, Ali Belfaitah, and Abdelmalek Bouraiou. "1-(2′-Benzimidazolylmethyl)-pyridinium ylide in the one-pot synthesis of indolizine and benzimidazo[1,2-a]pyridine derivatives." Zeitschrift für Naturforschung B 70, no. 8 (2015): 555–61. http://dx.doi.org/10.1515/znb-2015-0016.

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AbstractFour indolizine derivatives were obtained via 1,3-dipolar cycloaddition reaction of 1-(2′-benzimidazolylmethyl)pyridinium ylide with various electron-deficient alkynes. The reaction of this pyridinium N-ylide with dimethyl maleate gave an unexpected methyl 1-oxo-benzimidazo[1,2-a]pyridine-3-carboxylate. The structures of all reported compounds have been examined by X-ray crystallography and NMR spectroscopy.

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18

Tangeti, Venkata Swamy, and K. V. V. V. Satyanarayana. "Synthesis of Sulfonated Dihydrofuropyrazoles Derivatives as Antimicrobial Active Agents." Asian Journal of Chemistry 31, no. 4 (2019): 773–79. http://dx.doi.org/10.14233/ajchem.2019.21623.

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A series of sulfonyl dihydrofuropyrazole derivatives was prepared from one pot multi component condensation of sulfonated β-keto ester, aromatic aldehyde, hydrazine, pyridinium ylide in presence of piperidine catalyst under ethanol solvent conditions and subsequent oxidation of SPh group with MCPBA. All the synthesized compounds were characterized by analytical and spectral techniques and screened in vitro for antimicrobial activity. The activity data revealed that most of the compounds exhibited good to significant activities. Compounds 6b, 6i, 6j, 6k, 6m, 6n exhibited good and broad spectrum

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Silva, Eduarda M. P., Catarina I. V. Ramos, Patrícia M. R. Pereira та ін. "Cationic β-vinyl substitutedmeso-tetraphenylporphyrins: synthesis and non-covalent interactions with a short poly(dGdC) duplex". Journal of Porphyrins and Phthalocyanines 16, № 01 (2012): 101–13. http://dx.doi.org/10.1142/s1088424611004373.

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Several cationic beta-vinyl-pyridinium and beta-vinyl-quinolinium-meso-tetraphenylporphyrin derivatives were synthesized starting from 2-formyl-meso-tetraphenylporphyrin, and the corresponding Zn(II) complex, and different N-alkyl derivatives of 2- and 4-methylpyridine and 2- and 4-methylquinoline. The new compounds were obtained in a one-step process via base catalyzed aldol-type condensation reactions. Electrospray ionization mass spectrometry (ESI-MS) and ultraviolet-visible (UV-vis) spectroscopy were used to investigate the binding mode of the synthesized cationic beta-vinyl-pyridinium and

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Ghosh, Kumaresh, and Anupam Majumdar. "l-Amino acid derived pyridinium-based chiral compounds and their efficacy in chiral recognition of lactate." RSC Advances 5, no. 31 (2015): 24499–506. http://dx.doi.org/10.1039/c5ra00017c.

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A series ofl-amino acid derived pyridinium-based chiral compounds have been designed and synthesized. Among them, somel-valine derivatives show enantioselective recognition ofd-lactate in fluorescence.

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Foretić, Blaženka, Robert Vianello, Dubravka Matković-Čalogović, Dijana Jadreško, and Igor Picek. "Supramolecular inter-ionic charge-transfer complexes between derivatives of pyridinium-4-oxime cations and hexacyanoferrate(ii) anions." New Journal of Chemistry 42, no. 19 (2018): 16115–26. http://dx.doi.org/10.1039/c8nj03066a.

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Mono- and bis-pyridinium-4-oxime compounds are introduced as new electron acceptors for the formation of colored, supramolecular, inter-ionic charge-transfer complexes with hexacyanoferrate(ii) as a donor.

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22

Usta, Asu, and Hacer Taşkıran. "Synthesis and antimicrobial properties of N-substituted derivatives of (E)-2′,3″-thiazachalcones." Zeitschrift für Naturforschung C 70, no. 1-2 (2015): 45–50. http://dx.doi.org/10.1515/znc-2014-4182.

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Abstract N-alkyl substituted 2′,3″-thiazachalcones {3-[(1E)-3-(4-methylthiophene-2-yl)-3-oxoprop-1-en-1-yl]-1-alkyl (C5–12,14) pyridinium bromides} were synthesized by a two-step reaction. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, elemental analysis and mass spectral studies. The synthesized compounds were tested for antibacterial activities and found to be more active against Gram-positive as compared to Gram-negative bacteria.

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Tran, Vy Anh, Nguyen Hai Tai Tran, Long Giang Bach, et al. "Facile Synthesis of Propranolol and Novel Derivatives." Journal of Chemistry 2020 (August 24, 2020): 1–10. http://dx.doi.org/10.1155/2020/9597426.

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Propranolol is one of the first medications of the beta-blocker used for antihypertensive drugs. This study reports the facile route for the synthesis of propranolol and its novel derivatives. Herein, propranolol synthesis proceeded from 1-naphthol and isopropylamine under mild and less toxic conditions. Novel propranolol derivatives were designed by reactions of propranolol with benzoyl chloride, pyridinium chlorochromate, and n-butyl bromide through esterification, oxidation reduction, and alkylation, respectively. The isolation and purity of compounds were conducted using column chromatogra

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Molin, P., P. M. Fresneda, and M. J. Lidón. "Reaction of 2-Functionalized Pyridinium Salts with 1, 3-Dicarbonyl Compounds: Synthesis of Indolizine Derivatives." Synthetic Communications 15, no. 2 (1985): 109–15. http://dx.doi.org/10.1080/00397918508076816.

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Bruvere, Imanta, Egils Bisenieks, Janis Poikans, et al. "Dihydropyridine Derivatives as Cell Growth Modulators In Vitro." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–15. http://dx.doi.org/10.1155/2017/4069839.

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The effects of eleven 1,4-dihydropyridine derivatives (DHPs) used alone or together with prooxidant anticancer drug doxorubicin were examined on two cancer (HOS, HeLa) and two nonmalignant cell lines (HMEC, L929). Their effects on the cell growth (3H-thymidine incorporation) were compared with their antiradical activities (DPPH assay), using well-known DHP antioxidant diludine as a reference. Thus, tested DHPs belong to three groups:(1)antioxidant diludine;(2)derivatives with pyridinium moieties at position 4 of the 1,4-DHP ring;(3)DHPs containing cationic methylene onium (pyridinium, trialkyl

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Ebadi, Mojgan, Mohammad Reza Zolfaghari, Seyyed Soheil Aghaei, et al. "A bio-inspired strategy for the synthesis of zinc oxide nanoparticles (ZnO NPs) using the cell extract of cyanobacterium Nostoc sp. EA03: from biological function to toxicity evaluation." RSC Advances 9, no. 41 (2019): 23508–25. http://dx.doi.org/10.1039/c9ra03962g.

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Cyanobacteria, as one of the largest groups of phototrophic bacteria, have a high potential as an excellent source of fine chemicals and bioactive compounds, including lipid-like compounds, amino acid derivatives, proteins, and pigments.

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Kostenko, Nataliya, Jochen Gottfriedsen, Liane Hilfert, and Frank T. Edelmann. "A Synthetic Route to Quaternary Pyridinium Salt-Functionalized Silsesquioxanes." International Journal of Polymer Science 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/586594.

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A synthetic route to potentially biocidal silsesquioxanes functionalized by quaternary pyridinium functionalities has been developed.N-Alkylation reactions of the precursor compounds 4-(2-(trimethoxysilyl)ethyl)-pyridine (5) and 4-(2-trichloro-silylethyl)pyridine (6) with iodomethane,n-hexylbromide, andn-hexadecylbromide cleanly afforded the correspondingN-alkylpyridinium salts (7–10). The synthesis of a 4-(2-ethyl)pyridine POSS derivative (2) was achieved by capping of the silsesquioxane trisilanol Cy7Si7O9(OH)3(1) via two different preparative routes. Attempts to use compound2as precursor fo

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Shuai, Wen, Wenlong Li, Ying Yin, et al. "Design, synthesis and molecular modeling of isothiochromanone derivatives as acetylcholinesterase inhibitors." Future Medicinal Chemistry 11, no. 20 (2019): 2687–99. http://dx.doi.org/10.4155/fmc-2019-0125.

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Aim: A series of novel isothio- and isoselenochromanone derivatives bearing N-benzyl pyridinium moiety were designed, synthesized and evaluated as acetylcholinesterase (AChE) inhibitors. Results: Most of the target compounds exhibited potent anti-AChE activities with IC50 values in nanomolar ranges. Among them, compound 15a exhibited the most potent anti-AChE activity (IC50 = 2.7 nM), moderate antioxidant activity and low neurotoxicity. Moreover, the kinetic and docking studies revealed that compound 15a was a mixed-type inhibitor, which bounds to peripheral anionic site and catalytic active s

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Giyasov, K., G. S. Turaeva, and H. T. Turaeva. "Biological activity of benzoxazolinone and benzoxazolinthione derivatives." E3S Web of Conferences 258 (2021): 04017. http://dx.doi.org/10.1051/e3sconf/202125804017.

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The article presents the herbicidal, defoliating, fungicidal properties of the synthesized derivatives of benzoxazolinones and benzoxazolinethions. It was shown that 3-alkylbenzoxazolinones, 3-alkyl-6-halobenzoxazolinones and 2-alkylthiobenzoxazoles exhibit herbicidal action during the growing season of plants, and they also cause cotton leaves to drop up to 70%. It was found that 3-alkylbenzoxazolinones and 2-alkylthiobenzoxazoles exhibited fungicidal activity against the pathogen, Fugarium oxyporum and Verticillum dahlia. Among them, 2-methylthiobenzoxazole inhibited spores of the fungi Vert

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Canela-Xandri, Anna, Mercè Balcells, Gemma Villorbina, Paul Christou, and Ramon Canela-Garayoa. "Preparation and Uses of Chlorinated Glycerol Derivatives." Molecules 25, no. 11 (2020): 2511. http://dx.doi.org/10.3390/molecules25112511.

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Crude glycerol (C3H8O3) is a major by-product of biodiesel production from vegetable oils and animal fats. The increased biodiesel production in the last two decades has forced glycerol production up and prices down. However, crude glycerol from biodiesel production is not of adequate purity for industrial uses, including food, cosmetics and pharmaceuticals. The purification process of crude glycerol to reach the quality standards required by industry is expensive and dificult. Novel uses for crude glycerol can reduce the price of biodiesel and make it an economical alternative to diesel. More

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Marketaki, Maria, Eleftherios Touloupakis, Georgios Charalambidis, Marie-Cécile Chalbot, Demetrios F. Ghanotakis, and Athanassios G. Coutsolelos. "Synthesis, RNA binding and nuclease activity of porphyrin-hydroxamic acid derivatives." Journal of Porphyrins and Phthalocyanines 16, no. 09 (2012): 997–1005. http://dx.doi.org/10.1142/s1088424612501088.

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The interaction modes and nuclease activity against RNA of methylpyridiniumyl/phenyl-hydroxamic acid porphyrin adducts have been investigated. These compounds are derived from the tetracationic meso-tetrakis(N-methyl-4-pyridiniumyl)porphyrin (H2TMPyP-4) by replacing one or two pyridinium rings with a phenyl group. This group is bearing an aliphatic chain of three carbon atoms in the para position to a hydroxamic acid. A different interaction mode is observed depending on the number of charges and hydroxamic acid function. The nuclease activity of the porphyrin adducts against RNA has been demo

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Zhang, Shuai, and Liang-Nian He. "Capture and Fixation of CO2 Promoted by Guanidine Derivatives." Australian Journal of Chemistry 67, no. 7 (2014): 980. http://dx.doi.org/10.1071/ch14125.

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Guanidine compounds and their derivatives can be developed as catalysts, additives, or promoters in organic synthesis due to their unique chemical properties, which have attracted much attention in the chemistry and catalysis communities. Particularly, the strong basicity and ease of structural modification allow them to offer wide applications in the field of CO2 capture and conversion. Guanidine compounds modified as ionic liquids or heterogeneous catalysts have also been developed for CO2 capture and conversion. In this context, the latest progress on CO2 capture using guanidine and their d

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Barbera, Vincenzina, Sara Musto, Giuseppe Infortuna, et al. "SERINOL DERIVATIVES FOR THE SUSTAINABLE VULCANIZATION OF DIENE ELASTOMERS." Rubber Chemistry and Technology 91, no. 4 (2018): 701–18. http://dx.doi.org/10.5254/rct.18.81528.

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ABSTRACT 2-amino-1,3-propandiol (serinol) was used as the starting building block of synthetic pathways that led to the preparation of innovative chemicals suitable as ingredients for rubber compounds. Serinol based reactions were performed in the frame of a sustainable process, in the absence of any solvent and catalyst, with aldehydes and ketones, such as acetone, cinnamaldehyde and camphor. The synthesis of either imines or oxazolidines was obtained with high selectivity. Serinol, imine and oxazolidine derivatives of serinol were used as accelerator for the vulcanization of diene rubbers. T

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Barry, Samantha J., Richard M. Carr, Stephen J. Lane, William J. Leavens, Soraya Monté, and Ian Waterhouse. "Derivatisation for liquid chromatography/electrospray mass spectrometry: synthesis of pyridinium compounds and their amine and carboxylic acid derivatives." Rapid Communications in Mass Spectrometry 17, no. 6 (2003): 603–20. http://dx.doi.org/10.1002/rcm.957.

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Sundberg, Richard J., Deepak Dalvie, Joehassin Cordero, and H. A. Musallam. "Carbamate derivatives of 2-arylimidazo[1,2-a]pyridinium salts as acetylcholinesterase inhibitors and protective agents against organophosphorus compounds." Chemical Research in Toxicology 6, no. 4 (1993): 506–10. http://dx.doi.org/10.1021/tx00034a018.

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Igbinosa, Etinosa O., Emmanuel E. Odjadjare, Vincent N. Chigor, et al. "Toxicological Profile of Chlorophenols and Their Derivatives in the Environment: The Public Health Perspective." Scientific World Journal 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/460215.

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Chlorophenol compounds and their derivatives are ubiquitous contaminants in the environment. These compounds are used as intermediates in manufacturing agricultural chemicals, pharmaceuticals, biocides, and dyes. Chlorophenols gets into the environment from a variety of sources such as industrial waste, pesticides, and insecticides, or by degradation of complex chlorinated hydrocarbons. Thermal and chemical degradation of chlorophenols leads to the formation of harmful substances which constitute public health problems. These compounds may cause histopathological alterations, genotoxicity, mut

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37

Goda, Y., A. Kobayashi, K. Fukuda, S. Fujimoto, M. Ike, and M. Fujita. "Development of the ELISAs for detection of hormone-disrupting chemicals." Water Science and Technology 42, no. 7-8 (2000): 81–88. http://dx.doi.org/10.2166/wst.2000.0555.

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Six kinds of enzyme-linked immunosorbent assay (ELISA) systems were developed for the quantitative analysis of hormone-disrupting chemicals (HDCs), such as estrogen (ES: the total amount of estrone (E1), 17 β-estra (E2) and estriol (E3)), E2, bisphenol A (BPA), alkylphenol (AP), phthalate esters (PE) and chlorophenols (CP). To generate specific monoclonal antibodies against BPA, AP, PE, CP, hybridoma cells were produced by the fusion of mouse myeloma cells and spleen cells from mice immunized with carboxylated derivatives, while anti E2 monoclonal antibody was selected from those available on

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Foye, William O. "Sulfur Compounds in Therapy: Radiation-Protective Agents, Amphetamines, and Mucopolysaccharide Sulfation." Annals of Pharmacotherapy 26, no. 9 (1992): 1144–47. http://dx.doi.org/10.1177/106002809202600918.

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OBJECTIVE: Sulfur-containing compounds have been used in the search for whole-body radiation-protective compounds, in the design of amphetamine derivatives that retain appetite-suppressive effects but lack most behavioral effects characteristic of amphetamines, and in the search for the cause of kidney stone formation in recurrently stoneforming patients. METHODS: Organic synthetic procedures were used to prepare radiation-protective compounds having a variety of sulfur-containing functional groups, and to prepare amphetamine derivatives having electron-attracting sulfur functions. In the case

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Lee, Hing-Biu, and Thomas E. Peart. "Organic Contaminants in Canadian Municipal Sewage Sludge. Part I. Toxic or Endocrine-Disrupting Phenolic Compounds." Water Quality Research Journal 37, no. 4 (2002): 681–96. http://dx.doi.org/10.2166/wqrj.2002.046.

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Abstract The occurrence of toxic or endocrine-disrupting chemicals such as nonylphenol ethoxylates (NPEO), 4-nonylphenol (NP), 4-tert-octylphenol (OP), bisphenol A (BPA), triclosan (TCS), pentachlorophenol (PCP), hexachlorophene (HCP), and tetrabromobisphenol A (TBBPA) in 35 sewage sludge samples collected from cities across Canada is documented. Samples were extracted by supercritical carbon dioxide and the phenols were converted into their acetyl derivatives using published methods. The ethoxylates were analyzed by HPLC with a fluorescence detector. The other extracts, after silica gel colum

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Chalbot, Marie-Cécile, Leonidas Gryllos, Kosmas Kefokeris, et al. "DNA-Interaction and nuclease activity of porphyrin-hydroxamic acid derivatives in the presence of lanthanides." Journal of Porphyrins and Phthalocyanines 15, no. 07n08 (2011): 704–17. http://dx.doi.org/10.1142/s1088424611003665.

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The DNA-binding modes and nuclease activity of methylpyridiniumyl/phenyl-hydroxamic acid porphyrin adducts (PHAs) have been studied. These compounds are derived from the tetracationic meso-tetrakis(N-methyl-4-pyridiniumyl)porphyrin (H2TMPyP-4) by replacing one or two pyridinium rings by a phenyl group. A hydroxamic acid function was connected by a polymethylenic chain of 3 to 5 carbon atoms to the meta or para position of the phenyl group. Different DNA-interaction modes were observed depending on the number of charges and hydroxamic acid functions. The nuclease activity in the presence of lan

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Bąchor, Urszula, та Marcin Mączyński. "Selected β2-, β3- and β2,3-Amino Acid Heterocyclic Derivatives and Their Biological Perspective". Molecules 26, № 2 (2021): 438. http://dx.doi.org/10.3390/molecules26020438.

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Heterocyclic moieties, especially five and six-membered rings containing nitrogen, oxygen or sulfur atoms, are broadly distributed in nature. Among them, synthetic and natural alike are pharmacologically active compounds and have always been at the forefront of attention due to their pharmacological properties. Heterocycles can be divided into different groups based on the presence of characteristic structural motifs. The presence of β-amino acid and heterocyclic core in one compound is very interesting; additionally, it very often plays a vital role in their biological activity. Usually, such

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Hřebabecký, Hubert, and Antonín Holý. "Preparation of Thymidine-4'-C-carboxylic Acid and Its Derivatives." Collection of Czechoslovak Chemical Communications 62, no. 7 (1997): 1128–35. http://dx.doi.org/10.1135/cccc19971128.

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3',5'-Di-O-benzoyl-4'-C-hydroxymethylthymidine (3) was prepared in four steps from 3'-O-(tert-butyldimethylsilyl)-4'-C-hydroxymethylthymidine (1). Oxidation of 3 with pyridinium dichromate afforded 3',5'-di-O-benzoylthymidine-4'-C-carboxylic acid (4) which on debenzoylation gave free thymidine-4'-C-carboxylic acid, (3R,2S,5R)-3-hydroxy-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)tetrahydrofuran-2-carboxylic acid, (5). Esterification of acid 5 with diazomethane afforded the methyl ester 6. Its isopropyl ester 7 was obtained by transesterification of the methyl ester 6

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Sypniewski, Stanisław, and Edward Bald. "Ion-pair high-performance liquid chromatography of cysteine and metabolically related compounds in the form of their S-pyridinium derivatives." Journal of Chromatography A 676, no. 2 (1994): 321–30. http://dx.doi.org/10.1016/0021-9673(94)80432-x.

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Helson, Blair. "Naturally derived insecticides: Prospects for forestry use." Forestry Chronicle 68, no. 3 (1992): 349–54. http://dx.doi.org/10.5558/tfc68349-3.

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Much interest exists in using natural chemicals as insecticides. Plants manufacture a vast array of chemicals that help protect them against insect attack. These could serve as sources or models for future insecticides with novel modes of action that are highly effective and safe. Three compounds that are currently receiving much attention are examined for their potential for forestry use in Canada. These compounds are alpha-terthienyl from members of the flowering plant Family, Asteraceae; MK-244, a semi-synthetic analogue of abamectin, which is a natural avermectin compound from the soil mic

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Zhang, Jie, Mingyu Teng, and Dan Li. "Synthesis, characterization, photophysical and DNA photocleavage properties of amphiphilic porphyrins." Journal of Porphyrins and Phthalocyanines 18, no. 03 (2014): 221–30. http://dx.doi.org/10.1142/s1088424613501101.

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A series of amphiphilic porphyrins appended with pyridinium cation and/or polyethylene glycol have been synthesized and fully characterized by 1 H NMR, IR and MALDI-TOF-MS. Their photophysical properties were determined and the singlet oxygen (1 O 2) quantum yields of these compounds are in the range of 0.30–0.61 in CHCl 3 and 0.048–0.18 in Tris buffer. The measured two-photon absorption (TPA) cross-sections σ(2) of these porphyrin derivatives are between 110 and 240 GM. These amphiphilic porphyrins show some photocleavage activities (10%–21%) towards the anionic DNA observed at 100 μM.

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Rojas-Buzo, Sergio, Pilar García-García, and Avelino Corma. "Hf-based metal–organic frameworks as acid–base catalysts for the transformation of biomass-derived furanic compounds into chemicals." Green Chemistry 20, no. 13 (2018): 3081–91. http://dx.doi.org/10.1039/c8gc00806j.

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Molnar, Maja, Melita Lončarić, and Marija Kovač. "Green Chemistry Approaches to the Synthesis of Coumarin Derivatives." Current Organic Chemistry 24, no. 1 (2020): 4–43. http://dx.doi.org/10.2174/1385272824666200120144305.

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This review is a compilation of the green synthetic methods used in the synthesis of coumarin derivatives. Coumarins are a class of compounds with a pronounced wide range of biological activities, which have found their application in medicine, pharmacology, cosmetics and food industry. Their biological activity and potential application are highly dependent on their structure. Therefore, many researchers have been performing the synthesis of coumarin derivatives on a daily basis. High demands for their synthesis often result in an increased generation of different waste chemicals. In order to

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Stratienko, Elena N., Natalia P. Katunina, Fatima N. Tseeva, et al. "COMPARATIVE ANALYSIS OF ACTOPROTECTIVE PROPERTIES OF NEW CHEMICAL COMPOUNDS." Kuban Scientific Medical Bulletin 26, no. 2 (2019): 122–29. http://dx.doi.org/10.25207/1608-6228-2019-26-2-122-129.

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Aim. This study was aimed at searching and investigating new substances among phenylethyl derivatives of 3-hydroxypyridine, which exhibit a high actoprotective activity under the conditions of normoxia and acute hypobaric hypoxia.Materials and methods. New compounds of phenylethyl derivatives of 3-hydroxypyridine under the SC code (n = 23) were investigated in comparison with bemethyl and bromantane. The actoprotective activity of new compounds was assessed in experimental animals using a treadmill running test under the conditions of normoxia and acute hypobaric hypoxia. The studied chemical

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Abidov, Musa T. "Pharmacological aspects of hydrazides and hydrazide derivatives." Health Promotion & Physical Activity 2, no. 3 (2017): 9–21. http://dx.doi.org/10.5604/01.3001.0010.7718.

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Intense search for new antimicrobials, including anti-tuberculosis drugs, is dictated by the phenomenon of bacterial multidrug resistance. Hydrazides are considered the key intermediate and valuable starting material for some novel biologically active compounds. Over 70% of recently reported synthetic hydrazide derivatives are evaluated for antimicrobial and/or antifungal activity. The most frequently applied hydrazide is an anti- tuberculosis drug isoniazid/isonicotinic acid hydrazide (NIH). Hydrazide chemicals are sharing a common functional group characterized by a nitrogen- to-nitrogen cov

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Ji, Hongzhang, Changyue Wu, Min Ni, et al. "In vitro Antichlamydial Activity of 1,2,3,5-Tetrasubstituted Pyrrole Derivatives." Chemotherapy 63, no. 2 (2018): 95–99. http://dx.doi.org/10.1159/000487880.

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Background: Chlamydia is a group of bacterial pathogens distributed worldwide that can lead to serious reproductive and other health problems. The rise of antibiotic-resistant pathogens promotes the development of novel antichlamydial agents. The aim of this study is to assess in vitro antichlamydial activity of our previously synthesized 1,2,3,5- tetrasubstituted pyrroles. Methods: The derivatives were screened for their antichlamydial activity against three Chlamydia strains by calculating IC50 values using concentration-response inhibition data between 1 and 32 μM. The action of the compoun

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