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Journal articles on the topic 'Pyrido[1'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Cablewski, Teresa, Erin J. Carter, Craig L. Francis, Andris J. Liepa, and Michael V. Perkins. "N,N-Dialkyl-N′-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. III. Pyrido- and Pyridazo-Fused [1,2,4,6]Thiatriazine Dioxides." Australian Journal of Chemistry 60, no. 2 (2007): 105. http://dx.doi.org/10.1071/ch06367.

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N,N-Dialkyl-N′-chlorosulfonylchloroformamidines 1 reacted with 2-aminopyridines 2 to give novel pyrido[1,2-b][1,2,4,6]thiatriazine dioxides 3 and pyrido[2,1-c][1,2,4,6]thiatriazine dioxides 4. Reaction of 1 with 3-aminopyridazines 5 afforded pyridazo[3,2-c][1,2,4,6]thiatriazine dioxides 6 and a pyridazo[2,3-b][1,2,4,6]thiatriazine dioxide 7. The compounds 6 and 7 are derivatives of new ring systems.

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2

Refat, Hala M., and Khaled S. Mohamed. "Efficient and convenient synthesis of pyrido [2,1-b]benzothiazole, pyrimidopyrido[2,1-b]benzothiazole and benzothiazolo[3,2-a][1,8]naphthyridine derivatives." Heterocyclic Communications 21, no. 4 (2015): 219–24. http://dx.doi.org/10.1515/hc-2015-0018.

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AbstractNew 3-aryl-pyrido[2,1-b][1,3]benzothiazole derivatives 2a–e were synthesized in excellent yields via the reaction of benzothiazoleacetonitrile (1) with different aromatic aldehydes. The treatment of 2-(benzo[d]thiazol-2-yl)-3-(pyridin-4-yl)acrylonitrile (6) with malononitrile afforded 1-amino-3-(pyridin-4-yl)-3H-pyrido[2,1-b][1,3]benzothiazole-2,4-dicarbonitrile (7), which was allowed to react with a variety of reagents to provide pyrimido[5′,4′:5,6]pyrido[2,1-b][1,3]benzothiazole 8, 9 and [1,3]benzothiazolo[3,2-a][1,8]naphthyridine 10, 15 derivatives. All synthesized products were con

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3

Khan, Muhammad Naeem, Misbahul Ain Khan, Noreen Aslam, Pir Bakhsh Khan, and Ehsan ul Haq. "Tetracyclic Heteroaromatic Systems-Synthesis of Ethoxycarbonylphenylpyrido[3',2':5,6] Thiopyranoquinolines." Pakistan Journal of Scientific & Industrial Research Series A: Physical Sciences 64, no. 3 (2021): 191–94. http://dx.doi.org/10.52763/pjsir.phys.sci.64.3.2021.191.194.

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7-benzylideneamino-5H-thiochromeno[2,3-b]pyridin-5-ones and 9-benzylideneamino-5H-thio- chromeno[2,3-b]pyridin-5-ones, on reaction with ethyl pyruvate to afford 1-ethoxycarbonyl-3-phenyl-12H- pyrido[3',2':5,6]thiopyrano[3,2-f]quinoline-12-ones and 4-ethoxycarbonyl-2-phenyl-7H- pyrido[3',2':5,6]thiopyrano[3,2-h]quinoline-7-ones respectively by the two different methods. These products were precipitated by addition of ethanol, water (1:1), were purified by recrystalizing from appropriate solvents and were characterized from their IR, 1H-NMR, mass spectra and elemental analysis data.

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4

Yegorova, Tatyana, Bogdan Barnych, and Zoia Voitenko. "Reaction of pyrido[2,1-a]isoindole with 1,4-naphtoquinone and study of the product by spectroscopic methods." French-Ukrainian Journal of Chemistry 4, no. 2 (2016): 33–39. http://dx.doi.org/10.17721/fujcv4i2p33-39.

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Key role of the electronic structure of condensed isoindols in the way of the rearrangement was shown. Influence of the dienophile manifests in the requirement of the cyclic form of the dienophile itself. In the reaction of pyrido[2,1-a]isoindole with naphtoquinone rearrangement product of the first type was obtained and its structure was proven by spectral methods. Spectral criteria for the rearranged adducts of the first type for the pyrido[2,1-a]isoindole in the 13C NMR spectra were established. Products of reactions with naphthoquinone, 4-fluoro-, 2,5-difluorophenylmaleimides were isolated

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5

Tomashenko, Olesya A., Alexander F. Khlebnikov, Ivan P. Mosiagin, et al. "A new heterocyclic skeleton with highly tunable absorption/emission wavelength via H-bonding." RSC Advances 5, no. 115 (2015): 94551–61. http://dx.doi.org/10.1039/c5ra17755c.

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A new heterocyclic system, pyrido[2,1-a]pyrrolo[3,2-c]isoquinoline, showing stimuli responsive fluorescence, was synthesized via Pd-catalyzed intramolecular cyclization of 1-[1-benzyl-2-(2-bromophenyl)-1H-pyrrol-3-yl]pyridin-1-ium bromides.

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6

Abhishek, S. Saxena, Goel Atul, and Ji Ram Vishnu. "A convenient and expwitious synthesis of annulated N, S-heterocycles." Journal of Indian Chemical Society Vol. 80, Apr 2003 (2003): 311–18. https://doi.org/10.5281/zenodo.5839578.

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Medicinal Chemistry Division, Central Drug Research ln$titute, Lucknow-226 001, India E-mail : vjiram@yahoo.com_ Fax: 91-522-223405 <em>Manuscript received 19 September 2002</em> A convenient synthesis of titiett[2,3-<em>b</em>]pyridines (3), thieno[3,2-<em>c</em>]pxridines (4), pyrazolo[3,4-<em>b</em>]ipyridines (6), thieno[2,3- <em>d</em>]pyrimidines (9), pyridoll,2-althienol2,3-dlpyrimidines (11), pyrido[1,2-<em>a</em>]pyrimido141,51 : 4,5[thien:o[2,3-<em>d</em>]pyrimidines (12), pyrido[1,2-<em>a</em>]pyrimido[4,5-<em>d</em>]pyiimidines (13) and pyrazolor[3,4-<em>d</em>]pyrimido[1,2-a]pyrim

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7

Li, Ting, Zhen Wang, Mingliang Zhang, Hui-Jun Zhang та Ting-Bin Wen. "Rh/Cu-catalyzed multiple C–H, C–C, and C–N bond cleavage: facile synthesis of pyrido[2,1-a]indoles from 1-(pyridin-2-yl)-1H-indoles and γ-substituted propargyl alcohols". Chemical Communications 51, № 31 (2015): 6777–80. http://dx.doi.org/10.1039/c5cc01412c.

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The Rh/Cu-catalyzed synthesis of pyrido[2,1-a]indoles from 1-(pyridin-2-yl)-1H-indoles and γ-substituted propargyl alcohols involving multiple C–H, C–C, and C–N bond cleavage and construction is presented.

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8

Ma, Xingling, Lei Liu, Na Cao, Qiaogen Zou, Kaihe Xiong, and Pingkai Ouyang. "Isolation and Structural Elucidation of Palbociclib’s Eight Process-Related Impurities: Two Identified as New Compounds." Journal of AOAC INTERNATIONAL 99, no. 3 (2016): 638–48. http://dx.doi.org/10.5740/jaoacint.15-0251.

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Abstract Palbociclib is the first U.S. Food and Drug Administration-approved cyclin-dependent kinase inhibitor indicated in combination with letrozole for the treatment of breast cancer. Development of a selective method for the determination of any impurities contained in this drug is significantly important to ensure the quality and safety of palbociclib. In this study, a reliable reversed-phase HPLC method for the separation and determination of eight potential impurities was developed and validated. The structures of two new compounds and six other process-related impurities were character

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9

Tank, Manishkumar Jinabhai, Navinkumar A. Kucha, Chirag G. Naik, Tina R. Barot, and G. M. Malik. "Adamantane-pyrido[2,3-d]pyrimidine Derivatives; Synthesis, Characterization and Investigation of Antimicrobial Study." Oriental Journal Of Chemistry 39, no. 2 (2023): 393–402. http://dx.doi.org/10.13005/ojc/390219.

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Target molecules based on Adamantane-pyrido[2,3-d]pyrimidine derivatives were prepared. Adamantane-pyrido[2,3-d]pyrimidine series using N-(hydroxyadamantan-1-yl)-5-(2,4-substitutedphenyl)-2-Methyl-4-Oxo-7-(2-oxo-2H-Chromen-3-yl)pyrido[2,3-d]Pyrimidine-3(4H)carboxamide (6a-j) was synthesized by reaction between 3-(2-chloroacetyl)-5-(2,4-substitutedphenyl)-2-Methyl-7-(2-Oxo-2H-Chromen-3-yl) pyrido[2,3-d]pyrimidin-4(3H)-one (5a-j) and 3-aminoadamantan-1-ol. These derivatives of Adamantane-pyrido[2,3-d]Pyrimidine were investigated in vitro for their biological characteristics against the strains w

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10

Mohareb, R. M., and S. M. Fahmy. "Cyanothioacetamide in Heterocyclic Synthesis: A New Approach for the Synthesis of 2-Pyridothione and 2-Pyridazinothione Derivatives." Zeitschrift für Naturforschung B 41, no. 1 (1986): 105–9. http://dx.doi.org/10.1515/znb-1986-0122.

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Abstract Cyanothioacetamide (1) undergoes self condensation to give 4,6-diamino-3-cyano-2-pyrido-thione (2). The latter was utilised in synthesis of pyrido[2,3-c]pyrazole, pyrido[2,3-d]pyrim idine, bis-(pyridothione derivatives) through reaction with hydrazine hydrate, ethoxycarbonyl isothio-cyanate and cinnamonitrile derivatives. Also 1 undergoes self dimerisation to give 13, the latter form the pyridazine derivative on coupling with benzenediazonium chloride.

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11

Isakhanyan, A. U., N. Z. Hakobyan, Z. A. Hovasyan, et al. "Synthesis and effect of substituted pyrido[2,3-<i>d</i>]pyrimidine-2,4-diones on <i>In Vitro </i>tumor dna methylation." Журнал общей химии 93, no. 4 (2023): 525–30. http://dx.doi.org/10.31857/s0044460x23040042.

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Reaction of 3-diethylamino-1-aryl-, 3-diethylamino-1-aryl-2-phenyl(4-halophenyl)propane-1-ones hydrochlorides with 6-amino-1,3-dimethyluracil results in heterocyclization products, namely 1,3-dimethyl-7-aryl-5,6dihydro-1 H -pyrido[2,3- d ]pyrimidine-2,4-diones, 1,3-dimethyl-7-aryl-6-phenyl(4-halophenyl)-5,6-dihydro1 H -pyrido[2,3- d ]pyrimidine-2,4-diones and 1,3-dimethyl-7-aryl-6-phenyl-(4-halophenyl)-1 H -pyrido[2,3- d ] pyrimidine-2,4-diones. The effect of the synthesized compounds in vitro tumor DNA methylation was studied.

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12

Tiwari, Sangeeta, Ashok K. Yadav, and A. K. Mishra. "Some New Pyrido[2,3-d]pyridimines and their Nucleoside of Biological Importance." E-Journal of Chemistry 7, s1 (2010): S85—S92. http://dx.doi.org/10.1155/2010/812567.

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Chalcones (I) reacted with malanonitrile and ammonium acetate yielded 2-amino-3-cyano-4,6-disubstituted pyridines (II) in excellent yield. 4-Amino-5,7-disubstituted pyrido [2,3-d]pyrimidine-2(1H)-thiones (III), 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidines (IV) and 4-imino-3,5,7-trisubstituted pyrido[2,3-d]pyrimidin-2(1H)-ones (V) have been synthesized by the condensation of compound (II) with thiourea, formamide and arylisocynate respectively. The ribofuranosidesviz. 4-amino-5,7-disubstituted-1- [2',3',5'-tri-o-benzoyl-β,D-ribofuranosyl]pyrido[2,3-d]pyrimidine-2-(1H)-thiones (VI) and 4-i

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13

Sun, Yi, Wenfei Huang, Zhiqiang Li, Tao Wang, and Jin Luo. "Design, synthesis, and herbicidal activity of novel 2-(arylamino)-5-methyl-4-methylene-7-(methylthio)-4H-pyrido[4,3-d][1,3]oxazine-8-carbonitrile derivatives." Journal of Chemical Research 43, no. 3-4 (2019): 119–23. http://dx.doi.org/10.1177/1747519819845771.

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A series of 5-methyl-4-methylene-7-methylthio-2-arylmino-4 H-pyrido[4,3- d][1,3]oxazine-8-carbonitrile derivatives were synthesized via tandem aza-Wittig and annulation reactions with { N-[3-acetyl-5-cyano-2-methyl-6-(methylthio)pyridin-4-yl]imino}triphenylphosphorane and aryl isocyanate in dry dichloromethane. Their structures were clearly confirmed by infrared, 1H NMR, 13C NMR, high-resolution mass spectrometry, and X-ray single-crystal diffraction. All newly synthesized compounds were screened for herbicidal activities against monocotyledonous and dicotyledonous plants. The results indicate

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14

Lystsova, Ekaterina A., Alexander S. Novikov, Maksim V. Dmitriev, Andrey N. Maslivets, and Ekaterina E. Khramtsova. "Approach to Pyrido[2,1-b][1,3]benzothiazol-1-ones via In Situ Generation of Acyl(1,3-benzothiazol-2-yl)ketenes by Thermolysis of Pyrrolo[2,1-c][1,4]benzothiazine-1,2,4-triones." Molecules 28, no. 14 (2023): 5495. http://dx.doi.org/10.3390/molecules28145495.

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Acyl(imidoyl)ketenes are highly reactive heterocumulenes that enable diversity-oriented synthesis of various drug-like heterocycles. Such ketenes, bearing heterocyclic substituents, afford angularly fused pyridin-2(1H)-ones in their [4+2]-cyclodimerization reactions. We have utilized this property for the development of a new synthetic approach to pharmaceutically interesting pyrido[2,1-b][1,3]benzothiazol-1-ones via the [4+2]-cyclodimerization of acyl(1,3-benzothiazol-2-yl)ketenes generated in situ. The thermal behaviors of 3-aroylpyrrolo[2,1-c][1,4]benzothiazine-1,2,4-triones and 3-benzoylpy

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15

Agarwal, Alka, Shiv K. Agarwal, Som Nath Singh, Nigar Fatma, and R. K. Chatterjee. "Structure-Antifilarial Activity Relationship of 5/6/7/8-Mono-or Disubstituted 1H/1-Phenyl-9H-pyrido[3,4-b]indoles -A New Class of Potential Filaricides." Zeitschrift für Naturforschung C 49, no. 7-8 (1994): 526–30. http://dx.doi.org/10.1515/znc-1994-7-821.

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Antifilarial activity of 5/6/7/8-mono-or disubstituted 1 H /1-phenyl-9H -pyrido[3,4-b]indoles (I) has been described. The 1,6-and 8 -substituted 9H-pyrido[3,4-b]indoles (I) elicited interesting filaricidal activity against Litomosoides carinii and Acanthocheilonema viteae in rodent hosts

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16

Hamama, Wafaa S., Mohamed A. Ismail, Hana’a A. Al-Saman, and Hanafi H. Zoorob. "Convenient Selective Synthesis of Substituted Pyrido[2,3-d]pyrimidones and Annulated Derivatives." Zeitschrift für Naturforschung B 62, no. 1 (2007): 104–10. http://dx.doi.org/10.1515/znb-2007-0115.

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The reaction of 6-aminouracil (1) with the appropriate α,β -unsaturated ketones, gave the corresponding pyrido[2,3-d]pyrimidin-2,4-diones 3, 6, 8 and 10, respectively. Treatment of 1 with salicylaldehyde, 6-carboethoxy-3,5-diphenyl-2-cyclohexenone (13) or 2,6- bis(phenylmethylidene)cyclohexanone (15) afforded the corresponding pyrimido[4,5-d]quinoline- 2,4-diones 12, 14 and 16, respectively. Furthermore, a pyrido[2,3-d]pyrimidine incorporating 3,2’- bis(quinoline) derivative 18 was synthesized. Annulation of pyrido[2,3-d]pyrimidine with pyrazole or imidazole moieties was achieved via reaction

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17

Alshaye, Najla A., Al-Shimaa Badran, and Magdy A. Ibrahim. "Linear and Angular Heteroannulated Pyridines Tethered 6-Hydroxy-4,7-Dimethoxybenzofuran: Synthesis and Antimicrobial Activity." Molecules 29, no. 18 (2024): 4496. http://dx.doi.org/10.3390/molecules29184496.

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2-Chloropyridine-3-carbonitrile derivative 1 was utilized as a key precursor to build a series of linear and angular annulated pyridines linked to a 6-hydroxy-4,7-dimethoxybenzofuran moiety. Reaction of substrate 1 with various hydrazines afforded pyrazolo[3,4-b]pyridines. Treatment of substrate 1 with 1,3-N,N-binucleophiles including 3-amino-1,2,4-triazole, 5-amino-1H-tetrazole, 3-amino-6-methyl-1,2,4-triazin-5(4H)-one and 2-aminobenzimidazole produced the novel angular pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrimidine, pyrido[3,2-e][1,2,4]tetrazolo[1,5-a]pyrimidine, pyrido[3′,2′:5,6] pyrimido[2,

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18

Danyliuk, Ivanna, and Mykhailo Vovk. "SYNTHETIC APPROACHES TO HYDROGENIZED PYRIDYL[b]AZEPINE AND THEIR BENZENELYLATED ANALOGUES." Ukrainian Chemistry Journal 86, no. 8 (2020): 101–10. http://dx.doi.org/10.33609/2708-129x.86.8.2020.101-110.

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Pyrido[b]azepines are represented in the literature by four types of isomeric structures: pyrido[3,2-b] azepines, pyrido[2,3-b]azepines, pyrido[3,4-b] azepines and pyrido[4,3-b ]azepines. They belong to the structural analogues of 1-benzazepine - an attractive class of heterocycles with a strong pharmacological profile. They are also used as important molecular platforms in the construction of bioactive compounds. Analysis of the literature has shown that compounds that contain the pyrido[b]azepine fragment demonstrate antiviral, antimicrobial, and antitumor activity. They are knownas effectiv

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19

Bhaskar, J. Udaya, G. Srinivasa Rao, Pranab Chatterjee, D. K. Sahoo, S. Srinivasa Rao, and B. Pulla Rao. "Synthesis, Characterization and Antibacterial Activity of Some Novel Pyrido[2,3-b]indole, Morpholine and Chalcone Hybrid Compounds." Asian Journal of Chemistry 36, no. 11 (2024): 2598–602. http://dx.doi.org/10.14233/ajchem.2024.32585.

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In present investigation, a novel series of (E)-3-(2-morpholino-9H-pyrido[2,3-b]indol-3-yl)-1-phenylprop-2-en-1-one and its derivatives (5a-f) were synthesized by condensation reaction from the final intermediate, 2-morpholino-9H-pyrido[2,3-b]indol-3-carbaldehyde (4). The synthesis of the title compounds commenced from commercially available 21H-indol-2-amine (1) and by involving N-(1H-indol-2-yl)-acetamide (2) and 2-chloro-9H-pyrido[2,3-b]indole-3-carbaldehyde (3) as reactive intermediates. The chemical structure of synthesized compounds was characterized by IR, 1H NMR, mass spectral data and

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20

Arbain, D., LT Byrne, MV Sargent, BW Skelton, and AH White. "The Alkaloids of Picrasma javanica: Further Studies." Australian Journal of Chemistry 43, no. 2 (1990): 433. http://dx.doi.org/10.1071/ch9900433.

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The structures of two β- carboline alkaloids previously isolated from Picrasma javanica Bl . ( Simarubaceae ) are revised to 1-ethenyl-4-methoxy-9H-pyrido[3,4-b]indol-8-ol (8-hydroxydehydrocrenatine) (5) and 1-ethyl-4-methoxy-9H-pyrido[3,4-b]indol-8-ol (8-hydroxycrenatine) (6), chiefly on the grounds of a single-crystal X-ray structural determination of the former compound.

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21

Arbain, D., and MV Sargent. "The Alkaloids of Picrasma javanica." Australian Journal of Chemistry 40, no. 9 (1987): 1527. http://dx.doi.org/10.1071/ch9871527.

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Extraction of Picrasma javanica B1. (Simarubaceae) has yielded two new P- carboline alkaloids,1-ethenyl-4-methoxy-9 H- pyrido-[3,4-blindol-5-ol (5-hydroxydehydrocrenatine) (4) and l-ethyl-4-methoxy-9H-pyrido[3,4-blindol-5-ol (5-hydroxycrenatine) (5), the structures of which follow from their spectroscopic properties. In addition, the known alkaloids crenatine (2) and dehydrocrenatine (1) were isolated. Attempts to synthesize 1-ethyl-4,5-dimethoxy-9-methyl-9 Hpyrido [3,4-blindole(6) are described.

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22

Abdel-Hafez, Shams H., Ragaa A. Ahmed, Mohamed A. Abdel-Azim, and Khairy M. Hassan. "Selenium containing Heterocycles: Part 1. Synthesis of Some New Substituted Pyrido[3′,2′:4,5]selenolo[3,2-d]pyrimidines and Related Fused Tetracyclic Systems." Journal of Chemical Research 2007, no. 10 (2007): 580–84. http://dx.doi.org/10.3184/030823407x25506.

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New series of selenolo[2,3- b]pyridine, pyrido[3′,2′:4,5]selenolo[3,2- d]pyrimidine, 7,8-dihydro-2,4-dimethylpyrrolo [1,2- a]pyrido[3′,2′:4,5]selenolo[3,2- d]pyrimidin-10(6 H)-one and 7,9-dimethylpyrido[3′,2′:4,5]selenolo[3,2- d][1,2,4] triazolo[4,3- c]pyrimidine derivatives were synthesised from 3-cyano-4,6-dimethylpyridine-2(1 H)-selenone (1). Spectroscopic (IR, 1H, MS) of the newly synthesised compounds are reported.

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23

Koreňová, Anna, Alžbeta Krutošíková, Jaroslav Kováč, and Stanislav Celec. "Synthesis and reactions of furo[3,2-c]pyridine derivatives." Collection of Czechoslovak Chemical Communications 52, no. 1 (1987): 192–98. http://dx.doi.org/10.1135/cccc19870192.

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The synthesis of a new type of condensed heterocycle pyrido[3',4':4,5]furo[3,2-b]indole (V) and 1,2,4-triazolo[4'',3'':1',2']pyrido[3',4':4,5]furo[3,2-b]indoles (IX) is described and the substitution nucleophilic reaction with 2-(2-nitrophenyl)-4-chlorofuro[3,2-c]pyridine (X) is presented.

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24

Fulop, Ferenc. "Syntheses and Transformations of Azeto[2,1-a]- and -[2,1- b]isoquinolines and Azeto[1' ,2':1,2]pyrido[3,4-b]indoles." Current Organic Chemistry 3, no. 1 (1999): 1–24. http://dx.doi.org/10.2174/1385272803666220130205000.

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The syntheses, transformations and some of the biological features of azeto[2,1-a] and -[2,1-b]isoquinolines and azeto[1',2':1,2]pyrido[3,4-b]indoles are reviewed. Both angularly and linearly fused azetidine derivatives of isoquinolines are known. As concerns the related pyridoindoles, only the angularly fused azeto[1',2':1,2]pyrido[3,4-b]indoles have been prepared and investigated. The most interesting and characteristic transformations of azetoisoquinolines and azeto[1',2':1,2]pyrido[3,4-b]indoles are the ring enlargement reactions; these result, for example, in eight-membered ring derivati

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25

Tsuchiya, Hironori. "Comparative Effects ofα-,β-, andγ-Carbolines on Platelet Aggregation and Lipid Membranes". Journal of Toxicology 2011 (2011): 1–9. http://dx.doi.org/10.1155/2011/151596.

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Cigarette smoking and alcohol consumption possibly affect platelet functions. To verify the hypothesis that someα-,β-, andγ-carboline components in cigarette smoke and alcoholic beverages may change platelet aggregability, their effects on human platelets were determined by aggregometry together with investigating their membrane effects by turbidimetry. Carbolines inhibited platelet aggregation induced by five agents with the potency being 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole > 3-amino-1-methyl-5H-pyrido[4,3-b]indole > 1-methyl-9H-pyrido[3,4-b]indole. The most potent 3-amino-1,4-d

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26

Graf, Franziska, Lena Koehler, Torsten Kniess, Frank Wuest, Birgit Mosch, and Jens Pietzsch. "Cell Cycle Regulating Kinase Cdk4 as a Potential Target for Tumor Cell Treatment and Tumor Imaging." Journal of Oncology 2009 (2009): 1–12. http://dx.doi.org/10.1155/2009/106378.

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The cyclin-dependent kinase (Cdk)-cyclin D/retinoblastoma (pRb)/E2F cascade, which controls the G1/S transition of cell cycle, has been found to be altered in many neoplasias. Inhibition of this pathway by using, for example, selective Cdk4 inhibitors has been suggested to be a promising approach for cancer therapy. We hypothesized that appropriately radiolabeled Cdk4 inhibitors are suitable probes for tumor imaging and may be helpful studying cell proliferation processes in vivo by positron emission tomography. Herein, we report the synthesis and biological, biochemical, and radiopharmacologi

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Nguyen, Chi Hung, Émile Bisagni, and Jean-Marc Lhoste. "Synthèse de dérivés N-5 substitués des 5H-pyrido[4,3-b]benzo[f]indoles, isomères des 6H-pyrido[4,3-b]carbazoles (ellipticines)." Canadian Journal of Chemistry 64, no. 3 (1986): 545–51. http://dx.doi.org/10.1139/v86-087.

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2-Lithio dérivatives of 1-alkyl-4-chloropyrrolo[3,2-c]pyridines react with acetophenones, giving the corresponding tertiary alcohols. After déhydration into 1,1-diarylethylenes and subsequent reduction to 1,1 -diarylethanes, the synthesis of 1-chloro-5-alkyl-5H-pyrido[4,3-b]benzo[f]indoles was achieved either by direct cyclization with dichloromethylmethylether plus stannic chloride or by formylation and cyclodehydration with polyphosphoric acid. Finally, the substitution of the chlorine atom with dialkylaminoalkylamines leads to 1-amino substituted 5-alkyl-5H-pyrido[4,3-b]benzo[f]indoles, iso

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Kalyana Sundar, J., S. Natarajan, S. Chitra, et al. "Spectral Analysis and Crystal Structures of 4-(4-Methylphenyl)-6-Phenyl-2,3,3a, 4-Tetrahydro-1H-Pyrido[3,2,1-jk]Carbazole and 4-(4-Methoxyphenyl)-6-Phenyl-2,3,3a, 4-Tetrahydro-1H-Pyrido[3,2,1-jk]Carbazole." ISRN Organic Chemistry 2011 (April 17, 2011): 1–7. http://dx.doi.org/10.5402/2011/541082.

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The crystal structures of 4-(4-methylphenyl)-6-phenyl-2,3,3a,4-tetrahydro-1H-pyrido[3,2,1-jk]carbazole (IIa) and 4-(4-methoxyphenyl)-6-phenyl-2,3,3a,4-tetrahydro-1H-pyrido[3,2,1-jk]carbazole (IIb) were elucidated by single crystal X-ray diffraction. Compound (IIa), C28H25N, crystallizes in the triclinic system, space group P-1, with a=8.936(2) Å,b=10.490(1) Å,c=11.801(1) Å,α=102.69(5)°, β=103.27(3)°,γ=93.80(1)°, and Z=2. The compound (IIb), C28H25NO, crystallizes in the monoclinic system, space group P21/a, with a=11.376(5) Å,b=14.139(3) Å,c=13.237(4) Å,β=97.41(3)°, and Z=4. In both the struct

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Tber, Zahira, Mohammed Loubidi, Jabrane Jouha, et al. "Pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amines as Potential Cytotoxic Agents against Human Neuroblastoma." Pharmaceuticals 14, no. 8 (2021): 750. http://dx.doi.org/10.3390/ph14080750.

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We report herein the evaluation of various pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amines as potential cytotoxic agents. These molecules were obtained by developing the multicomponent Groebke–Blackburn–Bienaymé reaction to yield various pyrido[2′,1′:2,3]imidazo[4,5-c]quinolines which are isosteres of ellipticine whose biological activities are well established. To evaluate the anticancer potential of these pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amine derivatives in the human neuroblastoma cell line, the cytotoxicity was examined using the WST-1 assay after 72 h drug exposure. A clon

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30

Min, Lijing, Wei Liang, Joanna Bajsa-Hirschel, et al. "Synthesis, Herbicidal Activity, Mode of Action, and In Silico Analysis of Novel Pyrido[2,3-d]pyrimidine Compounds." Molecules 28, no. 21 (2023): 7363. http://dx.doi.org/10.3390/molecules28217363.

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Natural products are a main source of new chemical entities for use in drug and pesticide discovery. In order to discover lead compounds with high herbicidal activity, a series of new pyrido[2,3-d] pyrimidine derivatives were designed and synthesized using 2-chloronicotinic acid as the starting material. Their structures were characterized with 1H NMR, 13C NMR and HRMS, and the herbicidal activities against dicotyledonous lettuce (Lactuca sativa), field mustard (Brassica campestris), monocotyledonous bentgrass (Agrostis stolonifera) and wheat (Triticum aestivum) were determined. The results in

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Jarończyk, Małgorzata, Sławomir Ostrowski, and Jan Cz Dobrowolski. "On Integral INICS Aromaticity of Pyridodiazepine Constitutional Isomers and Tautomers." Molecules 28, no. 15 (2023): 5684. http://dx.doi.org/10.3390/molecules28155684.

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The structure, energetics, and aromaticity of c.a. 100 constitutional isomers and tautomers of pyrido[m,n]diazepines (m = 1, 2; n = 2, 3, 4, 5; m ≠ n) were studied at the B3LYP/cc-pVTZ level. The pyrido[1,3]diazepines appear the most, while pyrido[2,4]diazepines are the least stable (ca. 26 kcal/mol). In the pyrido[1,n]diazepine group (n = 2–5), the [1,5] isomers are higher in energy by ca. 4.5 kcal/mol and the [1,4] ones by ca. 7 kcal/mol, and the pyrido[1,2]diazepines are the least stable (ca. 20 kcal/mol). All the most stable pyrido[1,n]diazepines have N-atoms near the ring’s junction bond

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32

Lahmidi, Sanae, El Hassane Anouar, Walid Ettahiri, et al. "Nanoarchitectonics and Molecular Docking of 4-(Dimethylamino)Pyridin-1-Ium 2-3 Methyl-4-Oxo-Pyri-Do[1,2-a]Pyrimidine-3-Carboxylate." Crystals 13, no. 9 (2023): 1333. http://dx.doi.org/10.3390/cryst13091333.

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A retro-Claisen reaction of 1-(4-oxo-4H-pyrido [1,2-a]pyrimidin-3-yl)butane-1,3-dione, 3, in the presence of potassium hydroxide and 4-dimethylamino-pyridine has been carried out, leading to 4-(dimethylamino)pyridin-1-ium 2-methyl-4-oxo-pyrido [1,2-a]pyrimidine-3-carboxylate 5. A plausible mechanism explaining the formation of the title compound has been proposed. A single-crystal X-ray diffraction analysis confirms the crystal structure of the isolated organic salt (5). In the crystal, the title compound adopts a layered structure where there are stacks of cations and anions formed by slipped

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33

Gad-Elkareem, Mohamed A. M., Azza M. Abdel-Fattah, and Mohamed A. A. Elneairy. "Pyrazolo[3,4-b]pyridine in heterocyclic synthesis: synthesis of new pyrazolo[3,4-b]pyridines, imidazo[1',2':1,5]pyrazolo[3,4-b]pyridines, and pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidines." Canadian Journal of Chemistry 85, no. 9 (2007): 592–99. http://dx.doi.org/10.1139/v07-089.

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Pyrazolo[3,4-b]pyridine derivatives 7 and 9 were synthesized via the reaction of 3-amino-1H-pyrazolo-[3,4-b]pyridine derivative 2 with ω-bromoacetophenones. Reaction of 7 and 9 with Ac2O afforded the imidazo[1',2':1,5]py razolo[3,4-b]pyridine derivative 8 and pyrazolo[3,4-b]pyridine derivative 10, respectively. Reaction of 2 with chloroacetonitrile followed by DMF-DMA gave imidazo[1',2':1,5]pyrazolo[3,4-b]pyridines 4 and 5, respectively. Acetyl acetone and 1,1-dicyano-2,2-dimethylthioethene were reacted with 2 to afford the pyrido[2',3':3,4]pyrazolo-[1,5-a]-pyrimidines 11 and 14, respectively.

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34

Heinicke, J., B. R. Aluri, M. S. S. Adam, and P. G. Jones. "Novel Benzo-and Pyrido-Anellated 1, 3-Azaphospholes." Phosphorus, Sulfur, and Silicon and the Related Elements 183, no. 2-3 (2008): 779–82. http://dx.doi.org/10.1080/10426500701807905.

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35

Gadde, Satyanarayana, Yun Cheuk Leung, Mohan Bhadbade, Belamy B. Cheung, David StC Black, and Naresh Kumar. "Synthesis of a Novel Library of 1-Substituted Pyrido[1,2-a]benzimidazoles." Australian Journal of Chemistry 73, no. 12 (2020): 1208. http://dx.doi.org/10.1071/ch20173.

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The reactivity and synthesis of new analogues of pyrido[1,2-a]benzimidazoles have been explored. Twenty-three derivatives bearing phenoxy, thiophenoxy, aniline, and aryl groups at the 1-position were successfully synthesised in 25–91% yield, via nucleophilic substitution, Buchwald–Hartwig amination, and Suzuki coupling type processes. Solvent free synthetic protocols were employed to achieve the nucleophilic substitution of anilines with electron donating groups or moderately electron withdrawing groups on a sterically demanding intermediate (7a). An unusual polycyclic heterocycle was identifi

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36

Burova, O. A., N. M. Smirnova, and T. S. Safonova. "Pyrido[2,3-d]pyrimidines. 1. Acylation of 2,4,5-trioxo-7-amino-8H-pyrido [2,3-d]pyrimidines." Chemistry of Heterocyclic Compounds 26, no. 6 (1990): 677–80. http://dx.doi.org/10.1007/bf00756423.

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37

HERMECZ, I. "ChemInform Abstract: Chemistry of Pyrido[1,2-b][1,2]oxazines, Pyrido[1,2-b][1,2]thiazines, Pyrido[1,2-b]pyridazines, and Their Benzologues. Part 1." ChemInform 29, no. 11 (2010): no. http://dx.doi.org/10.1002/chin.199811301.

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38

Bobowski, George. "2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indoles.II. Reversible transformation of 1-alkyl-2-(4,9-dihydro-3H-pyrido[3,4-b]indol-1-yl)cyclohexanol into 1-alkylidene-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indoles." Journal of Heterocyclic Chemistry 24, no. 2 (1987): 473–79. http://dx.doi.org/10.1002/jhet.5570240232.

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39

N., K. MANDAL, SINHA R., and P. BANERJEE K. "Synthesis and Biological Activity of some Pyrido-2-carboxamido-pyrazoline and -isoxazoline Derivatives." Journal of Indian Chemical Society Vol. 63, Feb 1986 (1986): 221–22. https://doi.org/10.5281/zenodo.6241442.

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P. G. Department of Chemistry, Bhagalpur University, Bhagalpur-812 007 <em>Manuscript received 1 July 1985, accepted 2 December 1985</em> 2-Acetoacetamidopyridine on condensation with aromatic aldehydes yielded the corresponding pyrido-2-carboxamido-<em>α</em>,<em>β</em>-unsaturated ketones which on heating with hydrazine hydrate/phenylhydrazine and hydroxylamine hydrochloride gate the corresponding pyrido-2-carboxamido pyrazoline and isoxazoline derivatives. The biological activity of some representative compounds were tested.

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40

Shakoori, Alireza, John B. Bremner, Mohammed K. Abdel-Hamid, Anthony C. Willis, Rachada Haritakun, and Paul A. Keller. "Further exploration of the heterocyclic diversity accessible from the allylation chemistry of indigo." Beilstein Journal of Organic Chemistry 11 (April 15, 2015): 481–92. http://dx.doi.org/10.3762/bjoc.11.54.

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Diversity-directed synthesis based on the cascade allylation chemistry of indigo, with its embedded 2,2’-diindolic core, has resulted in rapid access to new examples of the hydroxy-8a,13-dihydroazepino[1,2-a:3,4-b']diindol-14(8H)-one skeleton in up to 51% yield. Additionally a derivative of the novel bridged heterocycle 7,8-dihydro-6H-6,8a-epoxyazepino[1,2-a:3,4-b']diindol-14(13H)-one was produced when the olefin of the allylic substrate was terminally disubstituted. Further optimisation also produced viable one-pot syntheses of derivatives of the spiro(indoline-2,9'-pyrido[1,2-a]indol)-3-one

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41

Abu-Hashem, Ameen Ali, and Sami A. Al-Hussain. "Design, Synthesis, Antimicrobial Activity, and Molecular Docking of Novel Thiazoles, Pyrazoles, 1,3-Thiazepinones, and 1,2,4-Triazolopyrimidines Derived from Quinoline-Pyrido[2,3-d] Pyrimidinones." Pharmaceuticals 17, no. 12 (2024): 1632. https://doi.org/10.3390/ph17121632.

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Background: Recently, pyrido[2,3-d] pyrimidine, triazolopyrimidine, thiazolopyrimidine, quinoline, and pyrazole derivatives have gained attention due to their diverse biological activities, including antimicrobial, antioxidant, antitubercular, antitumor, anti-inflammatory, and antiviral effects. Objective: The synthesis of new heterocyclic compounds including 5-quinoline-pyrido[2,3-d] pyrimidinone (1–2, 4, 6–7), 6-quinoline-pyrido[2,3-d]thiazolo[3,2-a]pyrimidinone (3, 5, 8–10), 1,2,4-triazole-6-quinoline-pyrido[2,3-d]thiazolo[3,2-a]pyrimidinone (11–13), and pyrido[2,3-d]thiazolo[3,2-a]pyrimidi

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42

Iwata, Satoru, and Kiyoshi Tanaka. "Electrochemical properties of pyrido[1′,2′:1,2]imidazo[4,5-b]pyrazine and pyrido[1′,2′:1,2]imidazo[4,5-b]quinoxaline derivatives." Journal of Heterocyclic Chemistry 35, no. 4 (1998): 939–41. http://dx.doi.org/10.1002/jhet.5570350426.

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43

Tantawy, Eman S., Mohamed S. Nafie, Hesham A. Morsy, Hassan A. El-Sayed, Ahmed H. Moustafa, and Samar M. Mohammed. "Synthesis of novel bioactive pyrido[2,3-d]pyrimidine derivatives with potent cytotoxicity through apoptosis as PIM-1 kinase inhibitors." RSC Advances 14, no. 16 (2024): 11098–111. http://dx.doi.org/10.1039/d4ra00902a.

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44

Abuelizz, Hatem A., Hanan A. A. Taie, Mohamed Marzouk, and Rashad Al-Salahi. "Synthesis and antioxidant activity of 2-methylthio-pyrido[3,2-e][1,2,4] triazolo[1,5-a]pyrimidines." Open Chemistry 17, no. 1 (2019): 823–30. http://dx.doi.org/10.1515/chem-2019-0092.

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AbstractA series of 2-methylthio-pyrido-triazolopyrimidines (1-17) were prepared by the reaction of dimethyl-N-cyanoimidodithiocarbonate with hydrazinopyridine carboxylic acid as starting reactants. Their chemical structures were affirmed with HREI-MS, IR and NMR analyses. The target compounds (1-17) were evaluated for their antioxidant activity using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ferric reduction antioxidant power (FRAP) and reducing power capability (RPC). The results revealed that some pyrido-triazolopyrimidines showed good activity as antioxidant agents, in part

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45

Jubete, Guillem, Raimon Puig de la Bellacasa, Roger Estrada-Tejedor, Jordi Teixidó, and José I. Borrell. "Pyrido[2,3-d]pyrimidin-7(8H)-ones: Synthesis and Biomedical Applications." Molecules 24, no. 22 (2019): 4161. http://dx.doi.org/10.3390/molecules24224161.

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Pyrido[2,3-d]pyrimidines (1) are a type of privileged heterocyclic scaffolds capable of providing ligands for several receptors in the body. Among such structures, our group and others have been particularly interested in pyrido[2,3-d]pyrimidine-7(8H)-ones (2) due to the similitude with nitrogen bases present in DNA and RNA. Currently there are more than 20,000 structures 2 described which correspond to around 2900 references (half of them being patents). Furthermore, the number of references containing compounds of general structure 2 have increased almost exponentially in the last 10 years.

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46

Belaroussi, R., A. Ejjoummany, A. El Hakmaoui, M. Akssira, G. Guillaumet, and S. Routier. "Three successive and regiocontroled palladium cross-coupling reactions to easily synthesize novel series of 2,4,6-tris(het)aryl pyrido[1′,2′:1,5]pyrazolo[3,4-d]pyrimidines." RSC Advances 8, no. 2 (2018): 732–41. http://dx.doi.org/10.1039/c7ra12246b.

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47

B.V.S, Suneel Kumar, Jagarlapudi A. R. P. Sarma, and Lakshmi Narasu. "3D-QSAR studies on Pyrido[2,3-d]pyrimidine Derivatives as Fibroblast Growth Factor Receptor 1 Inhibitors: Application of Molecular Field Analysis (MFA)." International Journal of Drug Design and Discovery 2, no. 4 (2024): 619–32. https://doi.org/10.37285/ijddd.2.4.2.

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Three-dimensional quantitative structure–activity relationship (3D-QSAR) models were developed for 77 pyrido[2,3-d]pyrimidines derivatives, inhibiting fibroblast growth factor receptor 1 (FGFR1). The QSAR model was developed using 56 compounds and its predictive ability was assessed using a test set of 21 compounds. The predictive 3D-QSAR models have conventional r2 values of 0.920 for MFA and the cross-validated coefficient r2cv values of 0.884 for MFA. The results of 3D-QSAR methodologies provide a powerful tool directed to the design of potent and selective pyrido[2,3-d]pyrimidines inhibito

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48

Domány, György, Csaba Szántay, Mária Bihari, and István Schön. "New Pyrimido[1′,6′:1,2]pyrido[3,4-b]indoles." Synthetic Communications 23, no. 13 (1993): 1787–94. http://dx.doi.org/10.1080/00397919308011278.

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49

KUNICK, C., and A. LINK. "ChemInform Abstract: Synthesis of Pyrido(3,4-d) (1)benzazepines." ChemInform 26, no. 45 (2010): no. http://dx.doi.org/10.1002/chin.199545199.

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50

Hassaneen, Huwaida M. E., Enas M. Awad, and Hamdi M. Hassaneen. "Studies with 6,7-Dimethoxy-3,4-dihydroisoquinolin-1-yl-acetonitrile: Novel Syntheses of 1-Azolyl- and Pyridoisoquinolines." Zeitschrift für Naturforschung B 62, no. 1 (2007): 111–16. http://dx.doi.org/10.1515/znb-2007-0116.

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The reaction of 3,4-dihydroisoquinolin-1-yl-acetonitrile with DMFDMA afforded the enaminonitrile 5. Compound 5 was reacted with 2-aminobenzimidazole to yield 4-amino-3-(dihydroisoquinolin- 1-yl)-benzo[4,5]imidazo[1,2-a]pyrimidine (11) and with acetonitrile derivatives to afford pyrido[2,1- a]isoquinolines (15a - g).

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