Academic literature on the topic 'Pyridopyridazine'

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Journal articles on the topic "Pyridopyridazine"

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Wojcicka, Anna, and Anna Nowicka-Zuchowska. "Synthesis and Biological Activity of Pyridopyridazine Derivatives: A Mini Review." Mini-Reviews in Organic Chemistry 16, no. 1 (2018): 3–11. http://dx.doi.org/10.2174/1570193x15666180220155119.

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This review presents most of the literature data about synthesis and biological activity of pyridopyridazine derivatives. There are six structural isomers of the bicyclic ring system containing pyridine moiety condensed with pyridazine nucleus. Pyridopyridazine derivatives show antitumor, antibacterial, analgesic and diuretics activities. The derivatives have been identified as the selective phosphodiesterase 5 and phosphodiesterase 4 inhibitors. Pyridopyridazines are novel class of GABA-A receptor benzodiazepine binding site ligands. Some of pyrido[3,2-c]pyridazine derivatives possess mollusc
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Asif, Mohammad. "Biological Potential and Chemical Properties of Pyridine and Piperidine Fused Pyridazine Compounds: Pyridopyridazine a Versatile Nucleus." Asian Journal of Chemistry and Pharmaceutical Sciences 1, no. 1 (2016): 29. http://dx.doi.org/10.18311/ajcps/2016/7693.

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Pyridopyridazine compounds are important nitrogen atom containing heterocyclic compounds due to their pharmacological versatility. This heterocycle system characterized a structural feature for different types of bioactive compounds that exhibiting various types of biological activities which make it an attractive scaffold for the design and development of new drug molecules. This article provided information about the pharmacological properties of pyridopyridazines derivatives.
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Ibrahim, Mohamed A., Ahmed H. Elmenoufy, Mohamed Elagawany, Mohammed M. Ghoneim, and Alaa Moawad. "“Pyridopyridazine”: A Versatile Nucleus in Pharmaceutical Field." Journal of Biosciences and Medicines 03, no. 10 (2015): 59–66. http://dx.doi.org/10.4236/jbm.2015.310008.

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Ji, Xiaoying, Koichi Kondo, Yoshio Aramaki, and Larry J. Kricka. "Effect of Enhancers on the Pyridopyridazine-Peroxide-HRP Reaction." Journal of Bioluminescence and Chemiluminescence 11, no. 1 (1996): 1–7. http://dx.doi.org/10.1002/(sici)1099-1271(199601)11:1<1::aid-bio389>3.0.co;2-2.

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Akçay, Sevilay, Mahmut Ülger, Fatma Kaynak Onurdağ, and Yasemin Dündar. "Study on Synthesis and Biological Activity of Some Pyridopyridazine Derivatives." Acta Chimica Slovenica 65, no. 4 (2018): 932–38. http://dx.doi.org/10.17344/acsi.2018.4590.

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M., A. HASSAN, and F. M. FAHMY A. "Synthesis and Structure Determination of 6-Chloro-1,2,4-triazolo[ 4,3-b ]pyrido[2,3-d] and [3,2-d]pyridazines." Journal of Indian Chemical Society Vol. 66, Feb 1989 (1989): 120–21. https://doi.org/10.5281/zenodo.6303568.

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Faculty of Science, Assint University (Qena), Egypt Faculty of Science, Ain Shams University, Egypt <em>Manuscript received 18 April&nbsp;1988, accepted 12 October 1988</em> 5,8-Dichloropyrido[2,3-<em>d</em>)pyridazine when treated with&nbsp;hydrazine hydrate gave a mixture of 5-chloro-8-hydrazino- and 8-chloro-5-hydrazinopyrido[2,3-<em>d</em>]pyridazines wbich&nbsp;when&nbsp;allowed to react with formic acid gave 6-chloro-1,2,4-triazolo[4,3-<em>b</em>)pyrido- (2,3-<em>d</em>) and [3,2-<em>d</em>]pyridazines.
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HUSSEIN, A. M., A. A. ATALLA, and A. M. K. EL-DEAN. "ChemInform Abstract: Novel Synthesis of Pyridopyridazine, Pyrrolopyridazine and Some Pyridazine Derivatives." ChemInform 27, no. 14 (2010): no. http://dx.doi.org/10.1002/chin.199614169.

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BHARDWAJ, GAUTAM, SURESH KUMAR, and RAJIV KUMAR TONK. "Anticancer and Antimicrobial Screening of Novel Pyrazolo[2,3-c]pyridopyridazine Analogues: Synthesis, Spectral Characterization, Molecular Docking and Dynamics Studies." Asian Journal of Chemistry 35, no. 11 (2023): 2837–44. http://dx.doi.org/10.14233/ajchem.2023.30477.

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A major threat in cancer management is the development of drug resistance and gene mutations. Serine threonine kinases like DYRK1A pathway are potential targets for cancer therapies. In this work, a new series of seven pyrazolo[2,3-c]pyridopyridazine analogs were synthesized and characterized by spectroscopic methods. Three compounds were evaluated for in-vitro anticancer activity following 60 cell lines protocol of NCI, USA and for antimicrobial activity against Gram-negative and Gram-positive bacteria. All the compounds exhibited moderate to good antibacterial activity, while compounds 4a, 4
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El-Sayed, A. Youssef, and Fathi A. Abu-Shanab. "Spectrophotometric and derivative spectrophotometric determination of palladium(II) using pyridopyridazine dithione in the presence of non-ionic surfactant." Mikrochimica Acta 129, no. 3-4 (1998): 225–31. http://dx.doi.org/10.1007/bf01244745.

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Selvakumar, Periasamy, Sathiah Thennarasu, and Asit Baran Mandal. "Synthesis of Novel Pyridopyridazin-3(2H)-one Derivatives and Evaluation of Their Cytotoxic Activity against MCF-7 Cells." ISRN Medicinal Chemistry 2014 (April 22, 2014): 1–7. http://dx.doi.org/10.1155/2014/410716.

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A series of pyridopyridazin-3(2H)-one derivatives was synthesized in two facile steps. Mannich-type three-component condensation afforded the 2,6-diaryl piperidin-4-one derivatives, which underwent intramolecular cyclization in the presence of hydrazine or phenylhydrazine to yield the corresponding pyridopyridazin-3(2H)-one derivatives. All the derivatives of pyridopyridazin-3(2H)-one, except 3e and 3f, showed moderate activity against human breast adenocarcinoma (MCF-7) cells. The higher degree of inhibition of MCF-7 cell proliferation shown by 2a–2f indicates the significance of the amide pr
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Book chapters on the topic "Pyridopyridazine"

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"Pyridopyridazines (Update 2012)." In Knowledge Updates 2012/2, edited by Aitken, Carreira, Li, Oestreich, Weinreb, and Yus. Georg Thieme Verlag, 2012. http://dx.doi.org/10.1055/sos-sd-116-00717.

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"Product Class 18: Pyridopyridazines." In Category 2, Hetarenes and Related Ring Systems, edited by Yamamoto and Shinkai. Georg Thieme Verlag, 2004. http://dx.doi.org/10.1055/sos-sd-016-01336.

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"7.2. Pyridodiazines: 7.2.1. Pyridopyridazines (I)." In Hetarenes IV, edited by Ernst Schaumann. Georg Thieme Verlag, 1998. http://dx.doi.org/10.1055/b-0035-118190.

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"7.2. Pyridodiazines: 7.2.1. Pyridopyridazines (II)." In Hetarenes IV, edited by Ernst Schaumann. Georg Thieme Verlag, 1998. http://dx.doi.org/10.1055/b-0035-118191.

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"7.2. Pyridodiazines: 7.2.1. Pyridopyridazines (III)." In Hetarenes IV, edited by Ernst Schaumann. Georg Thieme Verlag, 1998. http://dx.doi.org/10.1055/b-0035-118192.

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"7.2. Pyridodiazines: 7.2.1. Pyridopyridazines (IV)." In Hetarenes IV, edited by Ernst Schaumann. Georg Thieme Verlag, 1998. http://dx.doi.org/10.1055/b-0035-118193.

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Conference papers on the topic "Pyridopyridazine"

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Salaheldin, Abdellatif, Lígia Rodrigues, and Ana Oliveira-Campos. "Heterocyclic Synthesis with Nitriles: Synthesis of Pyridazine and Pyridopyridazine Derivatives." In The 11th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2007. http://dx.doi.org/10.3390/ecsoc-11-01319.

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