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Journal articles on the topic 'Pyridopyridazine'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Wojcicka, Anna, and Anna Nowicka-Zuchowska. "Synthesis and Biological Activity of Pyridopyridazine Derivatives: A Mini Review." Mini-Reviews in Organic Chemistry 16, no. 1 (2018): 3–11. http://dx.doi.org/10.2174/1570193x15666180220155119.

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This review presents most of the literature data about synthesis and biological activity of pyridopyridazine derivatives. There are six structural isomers of the bicyclic ring system containing pyridine moiety condensed with pyridazine nucleus. Pyridopyridazine derivatives show antitumor, antibacterial, analgesic and diuretics activities. The derivatives have been identified as the selective phosphodiesterase 5 and phosphodiesterase 4 inhibitors. Pyridopyridazines are novel class of GABA-A receptor benzodiazepine binding site ligands. Some of pyrido[3,2-c]pyridazine derivatives possess mollusc

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2

Asif, Mohammad. "Biological Potential and Chemical Properties of Pyridine and Piperidine Fused Pyridazine Compounds: Pyridopyridazine a Versatile Nucleus." Asian Journal of Chemistry and Pharmaceutical Sciences 1, no. 1 (2016): 29. http://dx.doi.org/10.18311/ajcps/2016/7693.

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Pyridopyridazine compounds are important nitrogen atom containing heterocyclic compounds due to their pharmacological versatility. This heterocycle system characterized a structural feature for different types of bioactive compounds that exhibiting various types of biological activities which make it an attractive scaffold for the design and development of new drug molecules. This article provided information about the pharmacological properties of pyridopyridazines derivatives.

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3

Ibrahim, Mohamed A., Ahmed H. Elmenoufy, Mohamed Elagawany, Mohammed M. Ghoneim, and Alaa Moawad. "“Pyridopyridazine”: A Versatile Nucleus in Pharmaceutical Field." Journal of Biosciences and Medicines 03, no. 10 (2015): 59–66. http://dx.doi.org/10.4236/jbm.2015.310008.

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4

Ji, Xiaoying, Koichi Kondo, Yoshio Aramaki, and Larry J. Kricka. "Effect of Enhancers on the Pyridopyridazine-Peroxide-HRP Reaction." Journal of Bioluminescence and Chemiluminescence 11, no. 1 (1996): 1–7. http://dx.doi.org/10.1002/(sici)1099-1271(199601)11:1<1::aid-bio389>3.0.co;2-2.

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5

Akçay, Sevilay, Mahmut Ülger, Fatma Kaynak Onurdağ, and Yasemin Dündar. "Study on Synthesis and Biological Activity of Some Pyridopyridazine Derivatives." Acta Chimica Slovenica 65, no. 4 (2018): 932–38. http://dx.doi.org/10.17344/acsi.2018.4590.

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6

M., A. HASSAN, and F. M. FAHMY A. "Synthesis and Structure Determination of 6-Chloro-1,2,4-triazolo[ 4,3-b ]pyrido[2,3-d] and [3,2-d]pyridazines." Journal of Indian Chemical Society Vol. 66, Feb 1989 (1989): 120–21. https://doi.org/10.5281/zenodo.6303568.

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Faculty of Science, Assint University (Qena), Egypt Faculty of Science, Ain Shams University, Egypt <em>Manuscript received 18 April 1988, accepted 12 October 1988</em> 5,8-Dichloropyrido[2,3-<em>d</em>)pyridazine when treated with hydrazine hydrate gave a mixture of 5-chloro-8-hydrazino- and 8-chloro-5-hydrazinopyrido[2,3-<em>d</em>]pyridazines wbich when allowed to react with formic acid gave 6-chloro-1,2,4-triazolo[4,3-<em>b</em>)pyrido- (2,3-<em>d</em>) and [3,2-<em>d</em>]pyridazines.

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7

HUSSEIN, A. M., A. A. ATALLA, and A. M. K. EL-DEAN. "ChemInform Abstract: Novel Synthesis of Pyridopyridazine, Pyrrolopyridazine and Some Pyridazine Derivatives." ChemInform 27, no. 14 (2010): no. http://dx.doi.org/10.1002/chin.199614169.

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8

BHARDWAJ, GAUTAM, SURESH KUMAR, and RAJIV KUMAR TONK. "Anticancer and Antimicrobial Screening of Novel Pyrazolo[2,3-c]pyridopyridazine Analogues: Synthesis, Spectral Characterization, Molecular Docking and Dynamics Studies." Asian Journal of Chemistry 35, no. 11 (2023): 2837–44. http://dx.doi.org/10.14233/ajchem.2023.30477.

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A major threat in cancer management is the development of drug resistance and gene mutations. Serine threonine kinases like DYRK1A pathway are potential targets for cancer therapies. In this work, a new series of seven pyrazolo[2,3-c]pyridopyridazine analogs were synthesized and characterized by spectroscopic methods. Three compounds were evaluated for in-vitro anticancer activity following 60 cell lines protocol of NCI, USA and for antimicrobial activity against Gram-negative and Gram-positive bacteria. All the compounds exhibited moderate to good antibacterial activity, while compounds 4a, 4

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9

El-Sayed, A. Youssef, and Fathi A. Abu-Shanab. "Spectrophotometric and derivative spectrophotometric determination of palladium(II) using pyridopyridazine dithione in the presence of non-ionic surfactant." Mikrochimica Acta 129, no. 3-4 (1998): 225–31. http://dx.doi.org/10.1007/bf01244745.

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10

Selvakumar, Periasamy, Sathiah Thennarasu, and Asit Baran Mandal. "Synthesis of Novel Pyridopyridazin-3(2H)-one Derivatives and Evaluation of Their Cytotoxic Activity against MCF-7 Cells." ISRN Medicinal Chemistry 2014 (April 22, 2014): 1–7. http://dx.doi.org/10.1155/2014/410716.

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A series of pyridopyridazin-3(2H)-one derivatives was synthesized in two facile steps. Mannich-type three-component condensation afforded the 2,6-diaryl piperidin-4-one derivatives, which underwent intramolecular cyclization in the presence of hydrazine or phenylhydrazine to yield the corresponding pyridopyridazin-3(2H)-one derivatives. All the derivatives of pyridopyridazin-3(2H)-one, except 3e and 3f, showed moderate activity against human breast adenocarcinoma (MCF-7) cells. The higher degree of inhibition of MCF-7 cell proliferation shown by 2a–2f indicates the significance of the amide pr

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11

Zheng, Xiaoyan, Congyu Ke, Sichang Wang, and Shenlin Huang. "Concise synthesis of pyridopyridazines." Tetrahedron Letters 149 (October 2024): 155263. http://dx.doi.org/10.1016/j.tetlet.2024.155263.

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12

Al-Zaydi, Khadijah M., and Mohamed H. Elnagdi. "Pyridopyridazines, Benzimidazolopyrimidines Triazolopyrimidines, 9-Oxo-2,3,6,7-tetraazabicyclo[3.3.1]nona-3,7-diene and Aroylcinnolines from 2-Arylhydrazono-3-oxopropanals." Zeitschrift für Naturforschung B 59, no. 6 (2004): 721–25. http://dx.doi.org/10.1515/znb-2004-0615.

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The reaction of the 2-arylhydrazonopropanal 3a with 2-amino1,1,3-tricyanopropene 4 afforded the pyridopyridazines 6. On the other hand, reaction of 3b with 4 afforded 7. Compounds 3a,b also condensed with 2-aminobenzimidazole and 3(5)-amino-1,2,4-triazole to yield azolopyrimidines 10 and 13. Refluxing compounds 3a,b in acetic acid in the presence of ammonium acetate afforded 2,3,6,7-tetraaza-bicyclo[3.3.1]nona-3,7-diene 14 and aroylcinnoline 15 respectively.

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13

Elnagdi, Mohamed Hilmy, Nadia Sobhy Ibrahim, Fathy Mohamed Abdelrazek, and Ayman Wahba Erian. "New routes to 1,3,4-oxadiazoles, 1,3,4-oxadiazolopyridines, and pyridopyridazines." Liebigs Annalen der Chemie 1988, no. 9 (1988): 909–11. http://dx.doi.org/10.1002/jlac.198819880917.

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14

Youssef, Mohamed Salah K., Amin F. Fahmy, Mohamed S. Abdel Halim, Mamdouh A. Hassan, and Jürgen Sauer. "SYNTHESIS OF ISOMERIC PYRIDOOXAZINONES, PYRIDOPYRIDAZINES AND TRIAZOLOPYRIDOPYRIDAZINES FROMo-AROYLPYRIDINECARBOXYLIC ACIDS." Organic Preparations and Procedures International 37, no. 3 (2005): 247–56. http://dx.doi.org/10.1080/00304940509354954.

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15

Kricka, L. J. "Selected strategies for improving sensitivity and reliability of immunoassays." Clinical Chemistry 40, no. 3 (1994): 347–57. http://dx.doi.org/10.1093/clinchem/40.3.347.

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Abstract Selected recent advances in immunoassay are reviewed. Development has continued on new labels (beta-lactamase, pyrophosphatase, luciferases, photoproteins, pyridopyridazines, europium cryptates, metal carbonyl complexes, porphines, phosphors) and label-detection methods (e.g., chemiluminescence assays, thermometric assays, NADP(+)- and FADP-based coupled assays). Various methods have been explored to increase assay sensitivity, including label amplification via catalyzed reporter deposition (peroxidase label) and immuno-polymerase chain reaction (DNA label). The focus of new immunoass

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16

Malinowski, Zbigniew, Dariusz Sroczyński, and Aleksandra K. Szcześniak. "Synthesis of Some Novel N-Substituted Phthalazinone and Pyridopyridazinone Derivatives." Synthetic Communications 45, no. 15 (2015): 1743–50. http://dx.doi.org/10.1080/00397911.2015.1025282.

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17

Kaizerman, Jacob A., Wade Aaron, Songzhu An, et al. "Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines." Bioorganic & Medicinal Chemistry Letters 20, no. 15 (2010): 4607–10. http://dx.doi.org/10.1016/j.bmcl.2010.06.006.

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18

Elmasry, Ghada F., Enayat E. Aly, Fadi M. Awadallah, and Samir M. El-Moghazy. "Design and synthesis of novel PARP-1 inhibitors based on pyridopyridazinone scaffold." Bioorganic Chemistry 87 (June 2019): 655–66. http://dx.doi.org/10.1016/j.bioorg.2019.03.068.

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19

Tynebor, Robert M., Meng-Hsin Chen, Swaminathan R. Natarajan та ін. "Synthesis and biological activity of pyridopyridazin-6-one p38α MAP kinase inhibitors. Part 2". Bioorganic & Medicinal Chemistry Letters 22, № 18 (2012): 5979–83. http://dx.doi.org/10.1016/j.bmcl.2012.07.035.

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20

Tynebor, Robert M., Meng-Hsin Chen, Swaminathan R. Natarajan, et al. "Synthesis and biological activity of pyridopyridazin-6-one p38 MAP kinase inhibitors. Part 1." Bioorganic & Medicinal Chemistry Letters 21, no. 1 (2011): 411–16. http://dx.doi.org/10.1016/j.bmcl.2010.10.128.

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21

Huestis, Malcolm P., Matthew R. Durk, Charles Eigenbrot, et al. "Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor." ACS Medicinal Chemistry Letters 12, no. 5 (2021): 791–97. http://dx.doi.org/10.1021/acsmedchemlett.1c00063.

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22

Fadda, Ahmed A., Ramy Rabie, Samir Bondock, and Hassan A. Etman. "Derivational, Structural, and Biological Studies of Some New Pyrazolyl, Isoxazolyl, Pyrimidinyl, Pyridazinyl, and Pyridopyridazinyl from 4-Substituted Antipyrine." Journal of Heterocyclic Chemistry 54, no. 2 (2016): 1304–10. http://dx.doi.org/10.1002/jhet.2707.

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23

Kobayashi, Satoru, Tomoki Furuya, Takashi Otani, and Takao Saito. "A novel and facile stereocontrolled synthetic method for polyhydro-quinolines and pyridopyridazines via a diene-transmissive Diels–Alder reaction involving inverse electron-demand hetero Diels–Alder cycloaddition of cross-conjugated azatrienes." Tetrahedron 64, no. 41 (2008): 9705–16. http://dx.doi.org/10.1016/j.tet.2008.07.102.

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24

Sako, M. "Pyridopyridazines." ChemInform 36, no. 17 (2005). http://dx.doi.org/10.1002/chin.200517275.

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25

DUNN, A. D. "ChemInform Abstract: THE SYNTHESIS OF PYRROLOPYRIDINES AND PYRIDOPYRIDAZINES." Chemischer Informationsdienst 16, no. 12 (1985). http://dx.doi.org/10.1002/chin.198512227.

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26

Youssef, Mohamed Salah K., Amin F. Fahmy, Mohamed S. Abdel Halim, and Mamdouh A. Hassan. "Synthesis of Isomeric Pyridooxazinones, Pyridopyridazines and Triazolopyridopyridazines from o-Aroylpyridinecarboxylic Acids." ChemInform 36, no. 42 (2005). http://dx.doi.org/10.1002/chin.200542171.

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27

ELNAGDI, M. H., N. S. IBRAHIM, F. M. ABDELRAZEK, and A. W. ERIAN. "ChemInform Abstract: New Routes to 1,3,4-Oxadiazoles, 1,3,4-Oxadiazolopyridines, and Pyridopyridazines." ChemInform 19, no. 49 (1988). http://dx.doi.org/10.1002/chin.198849176.

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28

Kulkarni, Vithal M., and Sujit Bhansali. "3D-QSAR of p38-α mitogen-activated protein kinase inhibitors: pyridopyridazin-6-ones (part 1)." Research and Reports in Medicinal Chemistry, October 2013, 29. http://dx.doi.org/10.2147/rrmc.s50737.

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29

Jain, Akhlesh K., Keerti Mishra та Suresh Thareja. "In Silico Docking of Anti Cancerous Drugs with β-Cyclodextrin polymer as a Prominent Approach to Improve the Bioavailability". Anti-Cancer Agents in Medicinal Chemistry 20 (13 жовтня 2020). http://dx.doi.org/10.2174/1871520620666201013145725.

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Background: β-Cyclodextrin, a cyclic oligosaccharides having 7 macrocyclic ring of glucose sub units usually linked together by ɑ-1,4 glycosidic bond, bears characteristic chemical structure, with exterior portion as hydrophilic to impart water solubility and interior cavity as hydrophobic, for hosting the hydrophobic molecules. Objective: In the present work binding affinities and interactions between various anti-cancerous drugs and β-cyclodextrin using molecular docking simulations was examined for the bioavailability enhancement of cytotoxic drugs through improved solubility for the treatm

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30

Al-Zaydi, Khadijah M., and Mohamed H. Elnagdi. "Pyridopyridazines, Benzimidazolopyrimidines, Triazolopyrimidines, 9-Oxo-2,3,6,7-tetraazabicyclo[3.3.1]nona-3,7-diene and Aroylcinnolines from 2-Arylhydrazono-3-oxopropanals." ChemInform 35, no. 41 (2004). http://dx.doi.org/10.1002/chin.200441040.

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31

Kulkarni, Vithal M., and Sujit Bhansali. "Pharmacophore generation, atom-based 3D-QSAR, docking, and virtual screening studies of p38-α mitogen activated protein kinase inhibitors: pyridopyridazin-6-ones (part 2)." Research and Reports in Medicinal Chemistry, December 2013, 1. http://dx.doi.org/10.2147/rrmc.s50738.

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32

Kobayashi, Satoru, Tomoki Furuya, Takashi Otani, and Takao Saito. "ChemInform Abstract: A Novel and Facile Stereocontrolled Synthetic Method for Polyhydro-quinolines and Pyridopyridazines via a Diene-Transmissive Diels-Alder Reaction Involving Inverse Electron-Demand Hetero Diels-Alder Cycloaddition of Cross-Conjugated Azatrienes." ChemInform 40, no. 11 (2009). http://dx.doi.org/10.1002/chin.200911157.

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