Relevant bibliographies by topics / Pyrrole-hydrazide

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Academic literature on the topic 'Pyrrole-hydrazide'

Author: Grafiati
Published: 4 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Pyrrole-hydrazide"

1

Torosyan, S. A., Z. F. Nuriakhmetova, F. A. Gimalova, and M. S. Miftakhov. "Synthesis of new 1,3,4-oxadiazole and 1,2,3-triazole derivatives based on thieno[3,2-<i>b</i>]pyrrolecarboxylic acid." Журнал органической химии 59, no. 2 (2023): 266–70. http://dx.doi.org/10.31857/s0514749223020143.

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Starting from 4-benzylthieno[3,2- b ]pyrrole-5-carboxylic acid hydrazide and 4-(2-propyn-1-yl)thieno[3,2- b ]pyrrole-5-carboxylic acid methyl ester new 1,3,4-oxadiazole and 1,2,4-triazole derivatives were obtained.
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2

Mateev, Emilio, and Maya Georgieva. "Biological evaluation, molecular docking and DFT calculations of pyrrole-based derivatives as dual acting AChE/MAO-B inhibitors." Pharmacia 70, no. 4 (2023): 1019–26. http://dx.doi.org/10.3897/pharmacia.70.e113014.

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Considering the complex pathophysiology of Alzheimer’s disease (AD), the multitarget ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target strategy. Thus, six pyrrole-based compounds were evaluated for their dual monoamine oxidase type B (MAO-B) and acetylcholinesterase (AChE) inhibitory capacities. Most of the compounds revealed good AChE activities at 10 µM concentrations. 5d most potently inhibited AChE with 75%, while the hydrazide 5 demonstrated blocking effect of 51% at 10 µM concentrations. However, li
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3

Mateev, Emilio, and Maya Georgieva. "Biological evaluation, molecular docking and DFT calculations of pyrrole-based derivatives as dual acting AChE/MAO-B inhibitors." Pharmacia 70, no. (4) (2023): 1019–26. https://doi.org/10.3897/pharmacia.70.e113014.

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Considering the complex pathophysiology of Alzheimer's disease (AD), the multitarget ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target strategy. Thus, six pyrrole-based compounds were evaluated for their dual monoamine oxidase type B (MAO-B) and acetylcholinesterase (AChE) inhibitory capacities. Most of the compounds revealed good AChE activities at 10 µM concentrations. 5d most potently inhibited AChE with 75%, while the hydrazide 5 demonstrated blocking effect of 51% at 10 µM concentrations. However, li
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4

Mateev, Emilio, Muhammed Tilahun Muhammed, Ali Irfan, Shubham Sharma, Maya Georgieva, and Alexander Zlatkov. "Hydrazide-hydrazones as novel antioxidants - in vitro, molecular docking and DFT studies." Pharmacia 71 (October 16, 2024): 1–8. http://dx.doi.org/10.3897/pharmacia.71.e133114.

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The pathogenesis of many diseases, such as obesity, depression, cancer, cataract, and neurodegenerative diseases, is related to the generation of reactive oxygen species (ROS). Structures possessing radical-scavenging properties act as antioxidants and they could prevent the progression of the aforementioned diseases. Therefore, the current work was focused on the resynthesis and the antioxidant evaluation of 13 hydrazide-hydrazones. Two in vitro tests - DPPH and ABTS, were applied for the determination of the antioxidant capacities. The free-radical scavenging assays displayed that the hydraz
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5

Mateev, Emilio, Muhammed Muhammed Tilahun, Ali Irfan, Shubham Sharma, Maya Georgieva, and Alexander Zlatkov. "Hydrazide-hydrazones as novel antioxidants - in vitro, molecular docking and DFT studies." Pharmacia 71 (October 16, 2024): 1–8. https://doi.org/10.3897/pharmacia.71.e133114.

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The pathogenesis of many diseases, such as obesity, depression, cancer, cataract, and neurodegenerative diseases, is related to the generation of reactive oxygen species (ROS). Structures possessing radical-scavenging properties act as antioxidants and they could prevent the progression of the aforementioned diseases. Therefore, the current work was focused on the resynthesis and the antioxidant evaluation of 13 hydrazide-hydrazones. Two <i>in vitro</i> tests - DPPH and ABTS, were applied for the determination of the antioxidant capacities. The free-radical scavenging assays displayed that the
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6

Mateev, Emilio, Valentin Karatchobanov, Marjano Dedja, et al. "Novel Pyrrole Derivatives as Multi-Target Agents for the Treatment of Alzheimer’s Disease: Microwave-Assisted Synthesis, In Silico Studies and Biological Evaluation." Pharmaceuticals 17, no. 9 (2024): 1171. http://dx.doi.org/10.3390/ph17091171.

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Considering the complex pathogenesis of Alzheimer’s disease (AD), the multi-target ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target strategy. Thus, one novel pyrrole-based hydrazide (vh0) and four corresponding hydrazide–hydrazones (vh1-4) were synthesized by applying highly efficient MW-assisted synthetic protocols. The synthetic pathway provided excellent yields and reduced reaction times under microwave conditions compared to conventional heating. The biological assays indicated that most of the novel
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7

Mateev, Emilio, Ali Irfan, Alexandrina Mateeva, Magdalena Kondeva-Burdina, Maya Georgieva, and Alexander Zlatkov. "In silico and in vitro screening of pyrrole-based Hydrazide-Hydrazones as novel acetylcholinesterase inhibitors." Pharmacia 71 (February 5, 2024): 1–7. http://dx.doi.org/10.3897/pharmacia.71.e114120.

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Virtual screening is emerging as a highly applied technique and gained prominence as widely used method for the search and identification of potential hits, significantly reducing the time needed to discover novel and effective compounds compared to high-throughput screening. Recently, the superiority of simulations with multiple programs compared to a single software docking has been discussed. The aim of this work was to apply consensus docking, molecular mechanics/generalized Born surface area (MM/GBSA) free binding energy recalculations, and in vitro evaluations on an in-house dataset of r
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8

Mateev, Emilio, Ali Irfan, Alexandrina Mateeva, Magdalena Kondeva-Burdina, Maya Georgieva, and Alexander Zlatkov. "In silico and in vitro screening of pyrrole-based Hydrazide-Hydrazones as novel acetylcholinesterase inhibitors." Pharmacia 71, no. () (2024): 1–7. https://doi.org/10.3897/pharmacia.71.e114120.

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Virtual screening is emerging as a highly applied technique and gained prominence as widely used method for the search and identification of potential hits, significantly reducing the time needed to discover novel and effective compounds compared to high-throughput screening. Recently, the superiority of simulations with multiple programs compared to a single software docking has been discussed. The aim of this work was to apply consensus docking, molecular mechanics/generalized Born surface area (MM/GBSA) free binding energy recalculations, and <i>in vitro</i> evaluations on an in-house datas
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9

Tzankova, Diana, Lily Peikova, Stanislava Vladimirova, and Maya Georgieva. "Development and validation of RP-HPLC method for stability evaluation of model hydrazone, containing a pyrrole ring." Pharmacia 66, no. (3) (2019): 127–34. https://doi.org/10.3897/pharmacia.66.e47035.

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RP-HPLC method with UV detection was developed and validated for determination of the chemical stability and stability in close to physiological conditions of a model pyrrole hydrazone ethyl 5-(4-bromophenyl)-1-(1-(2-(4-hydroxy-3-methoxybenzylidene) hydrazineyl)-4-methyl-1-oxopentan-2-yl)-2-methyl-1H-pyrrole-3-carboxylate (D_5d), containing susceptible to hydrolysis hydrazone group. The evaluated substance was subjected to the influence of a variety of pH , representing the main physiological values of 37°C and corresponding pH values in the stomach (pH 2.0), blood (pH 7.4) and small intestine
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10

Vladimirova, Stanislava, Rossitsa Hristova, and Ivan Iliev. "Synthesis, Cytotoxicity and Antiproliferative Effect of New Pyrrole Hydrazones." Molecules 29, no. 23 (2024): 5499. http://dx.doi.org/10.3390/molecules29235499.

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Novel pyrrole-based carbohydrazide (1) and hydrazones (1A–D) were synthesized, characterized, and subjected to spectroscopic studies. The hydrazones were obtained by reacting a pyrrole hydrazide with substituted pyrrole aldehydes. The initial carbohydrazide was prepared by selective hydrazinolysis of the obtained N-pyrrolylcarboxylic acid ethyl ester. The biological activity of the newly synthesized compounds was investigated in vitro on a panel of tumor and non-tumor cell lines. Mouse embryonic fibroblasts BALB 3T3 clone A31 were used in the safety test (BALB 3T3 NRU-assay). Antiproliferative
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Book chapters on the topic "Pyrrole-hydrazide"

1

Taber, Douglass F. "Heteroaromatic Construction: The Jia Synthesis of (-)- cis -Clavicipitic Acid." In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0065.

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Simultaneously, Aaran Aponick of the University of Florida (Organic Lett. 2009, 11, 4624) and Shuji Akai of the University of Shizuoka (Organic Lett. 2009, 11, 5002) reported the Au-mediate conversion of a propargylic diol such as 1 to the furan 2. Pyrroles can also be prepared using the same protocol. Jason K. Sello of Brown University developed (Organic Lett. 2009, 11, 2984) the direct aldol condensation of an acetoacetate 3 with the protected 1,3-dihydroxy acetone 4 to give 5, the methyl ester of a methylenomycin furan (MMF) bacterial-signaling molecule from Streptomyces coelicolor. Nobuhar
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Taber, Douglass. "Heterocycle Construction: The Chang Synthesis of Louisianin C." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0069.

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It has been known for some time that an acid chloride 1 can be added to an alkyne 2 to give the β-chloro enone. Yasushi Tsuji of Kyoto University found (J. Am. Chem. Soc. 2009, 131, 6668) that with an Ir catalyst, the condensation of 1 with 2 could be directed to the furan 3. Huanfeng Jiang of the South China University of Technology described (Organic Lett. 2009, 11, 1931) a complementary route to furans, Cu-mediated condensation of a propargyl alcohol 4 with the diester 5 to give 6. Bruce A. Arndtsen of McGill University developed (Organic Lett. 2009, 11, 1369) an approach to pyrroles such a
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