Relevant bibliographies by topics / Pyrrole Synthesis

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Academic literature on the topic 'Pyrrole Synthesis'

Author: Grafiati
Published: 11 December 2022
Last updated: 25 January 2023

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Journal articles on the topic "Pyrrole Synthesis"

1

Mohamed, Mosaad, Ramdan El-Domany, and Rania Abd El-Hameed. "Synthesis of certain pyrrole derivatives as antimicro-bial agents." Acta Pharmaceutica 59, no. 2 (June 1, 2009): 145–58. http://dx.doi.org/10.2478/v10007-009-0016-9.

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Synthesis of certain pyrrole derivatives as antimicro-bial agentsIn an effort to establish new pyrroles and pyrrolo[2,3-d] pyrimidines with improved antimicrobial activity we report here the synthesis andin vitromicrobiological evaluation of a series of pyrrole derivatives. A series of new 2-aminopyrrole-3-carbonitriles (1a-d) were synthesized from the reaction of benzoin, primary aromatic amines and malononitrile, from which a number of pyrrole derivatives (2a-dto5a-d) and pyrrolo[2,3-d]pyrimidines (6a-dto10a, d) were synthesized. Thein vitroantimicrobial testing of the synthesized compounds was carried out against Gram-positive, Gram-negative bacteria and fungi. Some of the prepared compounds, [2-amino-1-(2-methylphenyl)-4,5-diphenyl-1H-pyrrole-3-carbonitriles (1b), 2-amino-3-carbamoyl-1-(3-methylphenyl)-4,5-diphenyl-1H-pyrroles (2b),N-(3-cyano-1-(2-methylphenyl)-4,5-diphenyl-1H-pyrrol-2-yl)-acetamides (3b),N-(3-cyano-1-(3-methylphenyl)-4,5-diphenyl-1H-pyrrol-2-yl)-acetamides (3c), 2-amino-1-(4-methoxyphenyl)-4,5-diphenyl-3-tetrazolo-1H-pyrroles (5d),7-(4-methoxyphenyl)-5,6-diphenyl-7H-pyrrolo [2,3-d]pyrimidin-4(3H)-ones (7d), 7-(3-methylphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-thione (9b) andN-(7-(2-methylphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d] pyrimidine)-N-aryl amines (10a)] showed potent antimicrobial activity.
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Ta, Daniel D., Jeanne M. Favret, and Sergei V. Dzyuba. "Facile Synthesis of Pyrrolyl-Containing Semisquaraines in Water as Precursors for Non-Symmetric Squaraines." Compounds 3, no. 1 (December 28, 2022): 17–26. http://dx.doi.org/10.3390/compounds3010002.

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One-step reactions between squaric acid and pyrroles, such as 3-ethyl-2,4-dimethyl-pyrrole and 1,2,5-trimethylpyrrole, in water provide the corresponding pyrrol-2-yl- and pyrrol-3-yl-containing semisquaraines in high yields. These semisquaraines serve as useful precursors for the synthesis of various non-symmetric pyrrole-containing squaraine dyes.
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Quiclet-Sire, Béatrice, and Samir Zard. "Convergent Routes to Pyrroles Exploiting the Unusual Radical Chemistry of Xanthates – An Overview." Synlett 28, no. 20 (July 21, 2017): 2685–96. http://dx.doi.org/10.1055/s-0036-1590809.

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Convergent routes to a variety of pyrroles involving radical additions of xanthates are described. Emphasis is placed on reactions leading to the formation of 1,4-diketones or 1,4-ketoaldehydes or their synthetic equivalents, which can then be condensed with ammonia or primary amines in a variation of the classical Paal–Knorr synthesis of pyrroles. The modification of pyrroles by direct radical addition is also discussed.1 Introduction2 Earlier Routes to Pyrroles3 The Xanthate Radical Addition–Transfer Process4 Application to Pyrrole Synthesis5 Further Variations6 Direct Modification of Existing Pyrrole Rings7 Outlook and Perspectives
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Menéndez, J., Marco Leonardi, Verónica Estévez, and Mercedes Villacampa. "The Hantzsch Pyrrole Synthesis: Non-conventional Variations and Applications of a Neglected Classical Reaction." Synthesis 51, no. 04 (December 3, 2018): 816–28. http://dx.doi.org/10.1055/s-0037-1610320.

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Pyrrole is one of the most important one-ring heterocycles because of its widespread presence in natural products and unnatural bioactive compounds and drugs in clinical use. The preparation of pyrroles by reaction between primary amines, β-dicarbonyl compounds, and α-halo ketones, known as the Hantzsch pyrrole synthesis, is reviewed here for the first time. In spite of its age and its named reaction status, this method has received little attention in the literature. Recent work involving the use of non-conventional conditions has rejuvenated this classical reaction and this is emphasized in this review. Some applications of the Hantzsch reaction in target-oriented synthesis are also discussed.1 Introduction2 The Conventional Hantzsch Pyrrole Synthesis3 Hantzsch Pyrrole Synthesis under Non-conventional Conditions4 Applications of the Hantzsch Pyrrole Synthesis5 Conclusions
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Iqbal, Sarosh, Hina Rasheed, Rabiya Javed Awan, Ramsha Javed Awan, Asma Mukhtar, and Mark G. Moloney. "Recent Advances in the Synthesis of Pyrroles." Current Organic Chemistry 24, no. 11 (September 11, 2020): 1196–229. http://dx.doi.org/10.2174/1385272824999200528125651.

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: Pyrroles are the most prevalent heterocyclic compounds, which are present as the basic cores in many natural products, such as vitamin B12, bile pigments like bilirubin and biliverdin, the porphyrins of heme, chlorophyll, chlorins, bacteriochlorins, and porphyrinogens. The biological activities of compounds having pyrrole analogs include antimicrobial (antibacterial, antifungal), anti-cancer (anti-cytotoxic, antimitotic), anti-tumor, anti-hyperlipidemic, anti-depressant, anti-inflammatory, antihyperglycemic, antiproliferative, anti-HIV and anti-viral activities. Accordingly, significant attention has been paid to develop competent methods for the synthesis of pyrroles with improved yields in short times. This review gives an overview of different methods for the synthesis of pyrrole using easily available precursors using the following routes. . Synthesis of monosubstituted pyrrole using 2,5-dimethoxyfuran . Synthesis of pyrrole using dialkylacetylene dicarboxylate . Synthesis of pyrroles using β-ketoester . Synthesis of pyrrole using 1,2-dicarbonyl compounds . Synthesis of pyrroles using 1,3-dicarbonyl compounds . Synthesis of pyrroles using 1,3-dicarbonyl, amine, nitro and aldehyde group . Synthesis of pyrroles using 1,4-dicarbonyl compound and amines . Synthesis of pyrrole using enones . Synthesis of pyrroles using moieties having acetylene group
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Gao, Meng, Wenting Zhao, Hongyi Zhao, Ziyun Lin, Dongfeng Zhang, and Haihong Huang. "An efficient and facile access to highly functionalized pyrrole derivatives." Beilstein Journal of Organic Chemistry 14 (April 20, 2018): 884–90. http://dx.doi.org/10.3762/bjoc.14.75.

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A straightforward and one-pot synthesis of pyrrolo[3,4-c]pyrrole-1,3-diones via Ag(I)-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with N-alkyl maleimide, followed by readily complete oxidation with DDQ, has been successfully developed. Further transformation with alkylamine/sodium alkoxide alcohol solution conveniently afforded novel polysubstituted pyrroles in good to excellent yields. This methodology for highly functionalized pyrroles performed well over a broad scope of substrates. It is conceivable that this efficient construction method for privileged pyrrole scaffolds could deliver more active compounds for medicinal chemistry research.
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Chen, Fang, Parveen Akhtar, Leon A. P. Kane-Maguire, and Gordon G. Wallace. "Synthesis and Characterization of Chiral Conducting Polymers Based on Polypyrrole." Australian Journal of Chemistry 50, no. 9 (1997): 939. http://dx.doi.org/10.1071/c96189.

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A range of optically active pyrrole monomers have been synthesized in which a chiral sub- stituent is covalently bonded either to the pyrrole N or C3 ring position, namely (–)-(1R)-4-methyl-N-(1-phenylethyl)pyrrole-3-carboxamide, (+)-(1S)-4-methyl-N-(1-phenylethyl)pyrrole-3-carboxamide, (–)-(1R)-4-methyl-N-(1-naphthylethyl)pyrrole-3-carboxamide, (+)-(1S)-4-methyl-N-(1-naphthylethyl)pyrrole-3-carboxamide, (+)-(2S)-2-(1H-pyrrol-1-yl)propionic acid, (+)-(1S)-N-(1-phenyl-ethyl)pyrrole, and (–)-(1R)-N-(1-phenylethyl)pyrrole. Their chiroptical properties have been established by circular dichroism spectroscopy. Electropolymerization of the three N-substituted pyrrole monomers provided films of chiral conducting polymers, whose electrical and spectroscopic properties are described. Although oxidation of the C3 substituted pyrrole monomers was also facile, electrodeposition was poor and films of the associated polymers could not be obtained.
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Kumar, Anil, Israr Ahmad, and M. Sudershan Rao. "Ytterbium(III) triflate catalyzed synthesis of calix[4]pyrroles in ionic liquids." Canadian Journal of Chemistry 86, no. 9 (September 1, 2008): 899–902. http://dx.doi.org/10.1139/v08-121.

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Ytterbium(III) triflate has been utilized as a mild Lewis-acid catalyst for the synthesis of various calix[4]pyrroles by the condensation of pyrrole with different ketones in ionic liquids. The calix[4]pyrroles were obtained in high yield under ecofriendly, economical, and noncorrosive conditions, and the catalyst was recovered and recycled.Key words: calix[4]pyrrole, ionic liquid, ytterbium triflate.
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Reinus, Brandon, and Sean Kerwin. "A Copper-Catalyzed N-Alkynylation Route to 2-Substituted N-Alkynyl Pyrroles and Their Cyclization into Pyrrolo[2,1-c]oxazin-1-ones: A Formal Total Synthesis of Peramine." Synthesis 49, no. 11 (March 14, 2017): 2544–54. http://dx.doi.org/10.1055/s-0036-1588736.

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Screening of a variety of ligands and reaction conditions for the copper-catalyzed cross-coupling of alkynyl bromides with pyrroles, reveals that the use of the phenanthroline ligand 4,7-dimethoxy-1,10-phenanthroline affords a range of ynpyrroles in good to moderate yields. Furthermore, the utility of these ynpyrroles is demonstrated in the preparation of a series of pyrrolo[2,1-c][1,4]oxazin-1-ones and a formal total synthesis of the pyrrole natural product peramine.
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Portilla Zuniga, Omar Miguel, Angel Gabriel Sathicq, Jose Jobanny Martinez Zambrano, and Gustavo Pablo Romanelli. "Green Synthesis of Pyrrole Derivatives." Current Organic Synthesis 14, no. 6 (September 28, 2017): 865–82. http://dx.doi.org/10.2174/1570179414666161206124318.

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Background: Pyrroles are organic cyclic compounds with an extensive and fascinating chemistry. These compounds have a wide structural variety and they are an important basis in technological development as they can be used as drugs, dyes, catalysts, pesticides, etc. Therefore, the production of these heterocyclic compounds by efficient clean methodologies is a great achievement in contemporary chemistry. In this paper, we show recent green procedures in the synthesis of pyrrole derivatives such as Hantzsch, Knorr and Paal- Knorr syntheses, as well as new eco-friendly synthetic procedures with high efficiency and low environmental impact. Objective: This work focusses on the recent advances in the pyrrole synthesis using clean techniques like ultrasound (US), microwaves (MW), high speed vibration milling (HSVM), catalysts use, solvent replace and other methodologies applied to common reactions to obtain the pyrrole core which follow the green chemistry principles. Conclusion: The main challenge of Green Chemistry is to gradually eliminate the generation of hazardous or harmful materials or replace them with less toxic and safer ones. However, this process must be driven by scientific developments. Its application in the synthesis of heterocyclic compounds such as pyrrole derivatives involves multiple economic and social benefits due to the biological importance of these compounds and their direct impact on the pharmaceutical industry. Although many processes are still under investigation using novel methodologies of green activation such as microwaves, ultrasound and HSVM, as well as synthetic processes in continuous flow and processes at room temperature, promising results such as cost and waste reduction and greater efficiency are achieved.
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Dissertations / Theses on the topic "Pyrrole Synthesis"

1

Millan, Barrios Enrique Jose. "Synthesis and electrochemistry of pyrrole derivatives." Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242418.

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Armitage, Georgina Kate. "The Zav'yalov pyrrole synthesis revisited : some derivatives of 3-hydroxy- and 3-amino-pyrroles." Thesis, University of Huddersfield, 2017. http://eprints.hud.ac.uk/id/eprint/34175/.

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The objective of this study was to investigate the acylative-cyclisation-decarboxylation reactions of enamino acids derived from 1,3-difunctional compounds. Remarkably little is known regarding the generality of these variants of the Zav’yalov pyrrole synthesis, despite their considerable scope for the synthesis of functionalised pyrroles. The cyclisation of diethyl 2-(1-carboxyalkylaminomethylene)malonates provided access to a range of 5-(un)substituted-4-acetoxypyrrole-3-carboxylates. However, in some instances the corresponding 4-ethoxypyrrole-3-carboxylates also accounted for up to 20% of the reaction product. 1-Acetyl-4-ethoxy-5-ethylpyrrole-3-carboxylate was characterised by X-ray crystallography. Some of the (aminomethylene)malonates from bifunctional α-amino acids provided anomalous products. For example, the glutamine-derived enamino malonate gave a 5-acetylpyrrolidin-2-one via a Dakin-West-type reaction. The asparagine-enamino malonate cyclised to 4-acetoxy-1-acetyl-5-cyanomethylpyrrole-3-carboxylate probably via an isosuccinimide intermediate. Several mechanisms for the formation of the pyrrole products have been discussed. A 13C-labelling experiment confirmed that the carboxyl function in the starting material is not incorporated in the product. Evidence for the involvement of a 1,3-oxazolium-5-olate (münchnone) accrued from cyclisation of diethyl 2-(1-carboxymethylaminomethylene)malonate with Ac2O in the presence of dimethyl acetylenedicarboxylate which provided a novel 1-alkenylpyrrole, characterised by X-ray crystallography. An alternative pathway supervenes in the Zav’yalov reaction when α,α-disubstitution of the amino acid prevents münchnone and thus pyrrole formation to afford an N-alkenyloxazolidin-5-one. Novel ethyl 4-(di)acetamido-5-(un)substituted-pyrrole-3-carboxylates and the corresponding 3-carbonitriles have been obtained in good yields via the cyclisation of ethyl 2-(1-carboxyalkylaminomethylene)cyanoacetates and (1-carboxyalkylaminomethylene)malononitriles respectively. Evidence for a different cyclisation pathway, in the former, involving intramolecular acylation of the enaminonitrile moiety was observed. Thus, ethyl (2R*,3S*)-1-acetyl-3-cyano-2,4-diacetoxy-5-methyl-2,3-dihydropyrrole-3-carboxylate was characterised by X-ray crystallography. A wide range of novel 2-alkanoyl- and 2-aroyl-3-(1-carboxyalkylamino)acrylonitriles has been obtained via aminomethylenation of β-ketonitriles. The products from their cyclisations (Ac2O-NEt3) were largely independent of the nature of the acyl group but determined by the substituent in the α-amino acid moiety. The 3-(1-carboxy-1-phenylmethylamino)acrylonitriles provided mixtures of 3-acyl-4-(di)acetamido-5-phenylpyrroles in which the 4-acetamido- derivatives predominated. Contrasting behaviour was displayed by the 3-(1-carboxyalkylamino)acrylonitriles derived from alanine, 2-aminobutyric acid and valine in which the cyclisation followed an unexpected course, via enaminone acylation, to the novel 4-acetoxy-1-acetyl-5-alkylpyrrole-3-carbonitriles in high yields. The acylative cyclisation of the 2-acyl-3-(1-carboxymethylamino)acrylonitriles furnished mixtures of pyrroles. In two cases, 3-acetamido-6-aryl-5-cyanopyran-2-ones, generated by a unique cyclisation pathway were isolated. The structure of the 6-phenyl- derivative was confirmed by unambiguous synthesis. The synthesis and acylative cyclisation of (Z)-2-benzoyl-3-(1-carboxyalkylamino)crotononitriles was investigated. Whereas the 3-(1-carboxyethylamino)- derivative provided 4-acetoxy-1-acetyl-2,5-dimethylpyrrole-3-carbonitrile exclusively, the 3-(1-carboxy-1-phenylmethylamino)crotononitrile afforded a mixture of pyrroles. A remarkable minor component was characterised as 4-acetoxy-1-benzoyl-2-methyl-5-phenylpyrrole-3-carbonitrile, the result of sequential [1,5]-benzoyl migrations of a 3H-pyrrole intermediate. The acylative cyclisation of 3-(1-carboxyalkylamino)-2-tosylacrylonitriles provides access to hitherto unknown 3-diacetamido-4-tosyl- and 3-acetamido-4-tosylpyrroles. Cyclisation of 2-(1-carboxyalkylaminomethylene)dibenzoylmethanes offers an excellent, complementary approach to access 5-(un)substituted-3-benzoyl-4-phenylpyrroles, to the existing tosylmethyl isocyanide-based protocols.
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Ngwerume, Simbarashe. "Gold-multifaceted catalysis approach to pyrrole synthesis." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604293.

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The work presented in this thesis is concerned with the development of novel approaches to the regioselective synthesis of highly substituted pyrroles from simple starting materials. The work detailed herein covers three main research areas: i) A nucleophilic catalysis method for the concise synthesis of substituted NH- or N-Boc-pyrroles, directly from oximes and alkynes; ii) The development of a novel gold-multifaceted catalysis (gold-MFC) method for the regioselective synthesis NH-pyrroles directly from oximes and alkynes, together with a detailed mechanistic investigation which provides an insight into the mechanistic pathway; iii) studies towards an intramolecular macrocyclisation approach towards the synthesis of substituted pyrroles from oximes and alkynes. i) A novel nucleophilic catalysis / microwave irradiation protocol that provides a succinct synthesis of di-, tri, and tetrasubstituted pyrroles in a single operation will be discussed. This one-pot method relies on the use of a nucleophilic catalyst to regioselectively promote the in situ formation of O-vinyloximes from the reaction of oximes and electron deficient alkynes, which after subjection to microwave irradiation afforded the desired pyrroles as single regioisomers. ii) The main body of work in this thesis concerns the development of a novel gold(I)-catalysed method for the regioselective synthesis of highly substituted pyrroles directly from oximes and electron deficient alkynes. This one-pot method was developed via optimisation of two key gold(I)catalysed steps: the formation of O-vinyloximes and rearrangement of preformed O-vinyloximes into the corresponding pyrrole. The cationic gold species was shown to activate multiple mechanistically distinct steps along the reaction pathway and therefore act as a multifaceted catalyst. Notably, this method provides a concise synthesis of di-, tri- and tetrasubstituted pyrroles which contain a functional group handle in the form of an ester at the 3/4-position for further exploitation. The proposed mechanistic pathway is supported by a novel application of the Huisgen cycloaddition click reaction, which was used to probe the relative stability of substituted O-vinyloximes. Further support for the proposed mechanism was provided by high-temperature lH, 2H{lH}, and 13C{lH} NMR experiments. X-ray crystallographic evidence was used to further support the mechanistic hypothesis by confirming the absolute configuration of the oximes, 0- vinyloximes and pyrroles. iii) Preliminary studies into an unprecedented intramolecular pyrrole formation via the direct addition of an oxime to an alkyne are described. ii
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鍾惠玲 and Chung Wai-ling Margaret Chiu. "The synthesis and reactions of 3, 5-diaryl-2, 2-bis(ethoxycarbonyl)-2H-pyrroles." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1986. http://hub.hku.hk/bib/B31230829.

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李思明 and Sze-ming Lee. "An investigation into novel synthetic routes for 3h-pyrroles." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1989. http://hub.hku.hk/bib/B31209257.

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Maeda, Rina. "Synthesis and Evaluation of the Pyrrole-Imidazole Polyamides for Cancer Treatment." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263806.

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付記する学位プログラム名: 京都大学大学院思修館
京都大学
新制・課程博士
博士(総合学術)
甲第23345号
総総博第18号
京都大学大学院総合生存学館総合生存学専攻
(主査)教授 山敷 庸亮, 教授 杉山 弘, 教授 積山 薫
学位規則第4条第1項該当
Doctor of Philosophy
Kyoto University
DGAM
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Mezlova, Marie. "Benzofused thieno[3,2-b]pyrroles-synthesis, electrochemical and spectral behaviour." Paris 7, 2005. http://www.theses.fr/2005PA077212.

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This thesis deals with the synthesis of novel 1,4-diheteropentalene compounds, especially 4H-thieno[3,2-b]indoles and 1H-benzothieno[3,2-b]pyrrole, and the investigation of their electropolymerization. The aim was to prepare new conducting polymers and to determine how the structure of the monomer influences their electrochemical and spectral properties. The investigation can be subdivided into four parts. 1. In the context of the research on 1,4-diheteropentalenes performed in our laboratory in recent years, I have designed and prepared a series of novel thienoindoles and the isomeric benzothienopyrrole. The known synthetic procedure was extended to the preparation of thienoindoles with various electron-donating substituents in the benzene ring. After several unsuccessful synthetic approaches I found a new synthetic route to the thienoindole core. 2. The compounds synthesized are ideal candidates for the preparation of new conducting polymers which can be obtained by their electropolymerization. This hypotesis has already been proved by the polymerization of structurally related thieno[3,2-b]benzomiophenes. Thus, the second part of my research work has been focused on the electrochemical behaviour of the compounds prepared and on the electrosynthesis of polymers. This research work represents the first attempt to polymerize these 1,4-diheteropentalenes. 3. As a consequence with my research on polymer preparation, I have been also engaged in the investigation of their physicochemical and spectral properties. After the appropriate analyses I found that most of the polymers, obtained as films, are electroactive or conducting and consist of an oligomer mixture. Moreover, several exhibit very interesting spectral properties which designate them for applications in electrochromic devices or polymer-based light-emitting diodes. 4. I have also focused on the relationship between the structure of the monomer and the properties of the polymer. Electron-donating groups introduced into the thienoindole core, as well as the order of the pentalenes in the fused heterocycle, change basically the monomer reactivity towards polymerization, and determine the electroactivity and structure of the products. In addition, electron-donating substituents in the benzene ring of thienoindole have an essential influence on the spectral properties of the polymers.
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Lee, BoRa. "The Synthesis of Chemically Well-defined and Biocompatible Oligopyrroles for Tissue Engineering Applications." Phd thesis, Canberra, ACT : The Australian National University, 2016. http://hdl.handle.net/1885/102346.

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The studies described in this Thesis involve the development of syntheses of a wide range of chemically well-defined oligopyrroles for tissue engineering applications. In particular, the outcomes of a detailed investigation into the preparation of certain types of such oligopyrroles are presented using Suzuki-Miyaura cross-coupling reactions as a means for linking pyrrole-based building blocks.
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楊小雯 and Siu-man Yeung. "The synthesis and reactions of 3H-pyrroles bearing methyl and aryl groups." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1991. http://hub.hku.hk/bib/B31210119.

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Sandrin, Franco. "Lewis acid catalyzed reactions of 1-benzyl-2, 5-bis (trimethylsiloxy) pyrrole." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66047.

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Books on the topic "Pyrrole Synthesis"

1

Kawamoto, Yusuke. Synthesis and Biological Evaluation of Pyrrole–Imidazole Polyamide Probes for Visualization of Telomeres. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-6912-4.

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Voro, Tevita N. Synthesis of potentially biologically active indoles and pyrroles. Norwich: Universityof East Anglia, 1990.

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Elsadig, Hwaida Misbah. Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine peptoid oligomer libraries. [Portsmouth]: [University of Portsmouth], 2000.

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Gregson, Stephen John. Design, synthesis and evaluation of novel C2-unsaturated pyrrolo[2,1-c][1,4]benzodiazepines. Portsmouth: University of Portsmouth, School of Pharmacy and Biomedical Sciences, 1998.

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Roberts, David. The synthesis of pyrrolo[4,3,2-de]quinolines and approaches towards hinckdentine A and apparacine. Manchester: University of Manchester, 1996.

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Thompson, Andrew Spencer. Design, synthesis and evaluation of covalent-binding DNA-interactive ligands based on pyrrolo[2,1-c][1,4]benzodiazepines. Portsmouth: University of Portsmouth, School of Pharmacy and Biomedical Sciences, 1992.

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Corcoran, Kathryn Elizabeth. Synthetic approaches to C-ring unsaturated DNA cross-linking pyrrolo[2,1-c][1,4]benzodiazepine dimers. Portsmouth: University of Portsmouth, School of Pharmacy and Biomedical Sciences, 1998.

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Jones, Gary B. Design, synthesis and evaluation of DNA-binding oxazolo[2,3-c][1,4] benzodiazepines and pyrrolo[2,1-c][1,4] benzodiazepines. Portsmouth: Portsmouth Polytechnic, School of Pharmacy and Biomedical Sciences, 1991.

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González, Laura Maritza Calderón. Design, synthesis and evaluation of a scaffold and capping units based on the pyrrolo[2,1c][1,4]benzodiazepines for combinatorial chemistry. Portsmouth: University of Portsmouth, School of Pharmacy and Biomedical Sciences, 2000.

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Wilson, Stuart Craig. Design, synthesis and biological evaluation of a DNA cross-linking antitumour agent based onthe pyrrolo[2,1-c][1,4]benzodiazepine ring system. Portsmouth: University of Portsmouth, Division of Medicinal Chemistry and Natural Products, 1996.

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Book chapters on the topic "Pyrrole Synthesis"

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Li, Jie Jack. "Hantzsch pyrrole synthesis." In Name Reactions, 174. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05336-2_132.

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Li, Jie Jack. "Knorr pyrrole synthesis." In Name Reactions, 222. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05336-2_163.

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Li, Jie Jack. "Hantzsch pyrrole synthesis." In Name Reactions, 302–3. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03979-4_128.

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Li, Jie Jack. "Hantzsch pyrrole synthesis." In Name Reactions, 154. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-04835-1_123.

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Li, Jie Jack. "Knorr pyrrole synthesis." In Name Reactions, 197. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-04835-1_153.

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Li, Jie Jack. "Hantzsch pyrrole synthesis." In Name Reactions, 276. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-01053-8_120.

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Li, Jie Jack. "Paal-Knorr pyrrole synthesis." In Name Reactions, 295. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05336-2_220.

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Li, Jie Jack. "Paal–Knorr pyrrole synthesis." In Name Reactions, 454–55. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03979-4_202.

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Li, Jie Jack. "Paal-Knorr pyrrole synthesis." In Name Reactions, 266. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-04835-1_209.

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Li, Jie Jack. "Paal–Knorr pyrrole synthesis." In Name Reactions, 411–12. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-01053-8_189.

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Conference papers on the topic "Pyrrole Synthesis"

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Assis, Francisco F. de, Timothy J. Brocksom, and Kleber T. de Oliveira. "Synthesis of 3,4-dibromo-1H-pyrrole-2-carbaldehyde: a building block for preparation of tetrabromobacteriochlorins." In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013913103524.

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Raposo, M., Ana Sousa, A. Fonseca, and G. Kirsch. "Synthesis and UV-Visible Properties of Thienyl-Substituted Pyrrole Azo Dyes." In The 8th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2004. http://dx.doi.org/10.3390/ecsoc-8-01949.

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Mohan, G., N. Saichaitanya, S. Murali, N. Bakthavatchala Reddy, Grigory V. Zyryanov, and C. Suresh Reddy. "Ultrasound-assisted PSA catalyzed one-pot green synthesis of pyrazolyl pyrrole derivatives." In PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0018172.

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GORKA, JOANNA, and MIETEK JARONIEC. "SBA-15 TEMPLATING SYNTHESIS AND PROPERTIES OF PYRROLE-BASED ORDERED MESOPOROUS CARBONS." In Proceedings of the 5th International Symposium. WORLD SCIENTIFIC, 2008. http://dx.doi.org/10.1142/9789812779168_0036.

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Wang, Caolin, Yuanbiao Tu, Jiaqian Han, and Yuping Guo. "Synthesis of 1-(2-(piperidin-1-yl)ethyl)-1H-pyrrole-2-carbaldehyde." In 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016). Paris, France: Atlantis Press, 2017. http://dx.doi.org/10.2991/emcm-16.2017.114.

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Ghafuri, Hossein, and Hamid Reza Esmaili Zand. "Basic GO-Imidazolium ionic liquid as a recoverable nanocatalyst for the synthesis of pyrrole derivatives." In The 21st International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2017. http://dx.doi.org/10.3390/ecsoc-21-04866.

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Liu, Gang, Shouzhi Pu, and Congbin Fan. "Efficient synthesis, photochromism, and holographic optical recording of a photochromic diarylethene bearing a pyrrole unit." In Photonics and Optoelectronics Meetings 2009, edited by Masud Mansuripur, Changsheng Xie, and Xiangshui Miao. SPIE, 2009. http://dx.doi.org/10.1117/12.843328.

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Gašparová, Renata, Mária Maliarová, Tatiana Ďurčeková, Filip Kraic, and Ján Titiš. "Synthesis of furo[3,2-b]pyrrole-5-carboxhydrazides and Their Cu, Ni and Co Complexes." In The 15th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2011. http://dx.doi.org/10.3390/ecsoc-15-00568.

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Castro, M. Cidália R., A. Maurício C. Fonseca, M. Belsley, and M. Manuela M. Raposo. "Synthesis and evaluation of NLO properties of π-conjugated donor-acceptor systems bearing pyrrole and thiophene heterocycles." In International Conference on Applications of Optics and Photonics, edited by Manuel F. Costa. SPIE, 2011. http://dx.doi.org/10.1117/12.892124.

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Hussein, Ola, Feras Alali, Ala-Eddin Al Moustafa, and Ashraf Khalil. "Design, Synthesis and Biological Evaluation of Novel Chalcone Analogs as Potential Therapeutic Agents for Castration-Resistant Prostate Cancer." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0179.

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Abstract:
Prostate cancer (PCa) is the second most frequently diagnosed malignancy, as well as a leading cause of cancer-related mortality in men globally. Despite the initial response to hormonal targeted therapy, the majority of patients ultimately progress to a lethal form of the disease, termed as castration-resistant prostate cancer (CRPC), which currently lacks curative therapeutic options and is associated with poor prognosis. Therefore, the development of novel treatment modalities for PCa is urgently needed. Chalcones, also known as 1,3-diphenyl-2-propen-1-ones, are among the highly attractive scaffolds being investigated for their antitumor activities. Three series of 18 cyclic (tetralone-based) and two acyclic chalcone analogs, in which ring B was either substituted with nitrogen mustard or replaced by pyrrole or pyridine heterocyclic rings, were designed, synthesized and evaluated as potential therapies for CRPC. Compounds were synthesized by Claisen-Schmidt condensation reaction, purified using columnchromatography or recrystallization and characterized by 1H-NMR, 13C-NMR and LC-MS. The compounds' in-vitro cytotoxicity was evaluated against three prostate cancer cell lines (PC3, DU145, and LNCaP). Among the tested compounds, OH14, OH19 and OH22 showed potent antiproliferative activities at low micromolar levels with IC50 values ranging between 4.4 and 10 µM against PC3 and DU145 cell lines. Detailed biological studies of the lead molecule OH19 revealed that it significantly induces apoptosis through upregulation of Bax and downregulation of BCL-2. In addition, OH19 potently inhibits colony formation and reduces cell migration of androgen-independent PCa cell lines (PC3 and DU145). The molecular pathway analysis show that the anticancer activity of OH19 is associated with attenuation in the phosphorylation of Akt and ERK. Furthermore, OH19 inhibits blood vessel formation in the chick chorioallantoic membrane (CAM) model as compared to control. These results indicate that OH19 could serve as a potential promising lead molecule for the treatment of CRPC and thus, further in-vitro and invivo studies are warranted.
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Reports on the topic "Pyrrole Synthesis"

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Allcock, Harry R., Jeffrey A. Dodge, Leon S. Van Dyke, and Charles R. Martin. Polyphosphazenes Bearing Polymerizable Pyrrole, Thiophene and Furan Side Groups: Synthesis and Chemical Oxidation. Fort Belvoir, VA: Defense Technical Information Center, April 1992. http://dx.doi.org/10.21236/ada249747.

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Shu, Ching-Fong, and Mark S. Wrighton. Synthesis and Charge Transport Properties of Polymers Derived from Oxidation of 1-H-1'(6-pyrrol-1-yl)-hexyl-4,4'-bipyridinium. Fort Belvoir, VA: Defense Technical Information Center, August 1988. http://dx.doi.org/10.21236/ada198070.

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[Studies of hydrogen-hydrogen and carbon-sulfur bond cleavage; Lewis acid modified molybdenum sulfide complexes; and Syntheses and reactions of pyrrole complexes]. Final report. Office of Scientific and Technical Information (OSTI), January 1998. http://dx.doi.org/10.2172/650154.

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