Academic literature on the topic 'Pyrrolidine derivatives'

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Journal articles on the topic "Pyrrolidine derivatives"

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Smolobochkin, Andrey V., Almir S. Gazizov, Rakhymzhan A. Turmanov, Dinara S. Abdullaeva, Alexander R. Burilov, and Michail A. Pudovik. "N-Phosphorylated Pyrrolidines: An Overview of Synthetic Approaches." Synthesis 52, no. 15 (2020): 2162–70. http://dx.doi.org/10.1055/s-0039-1690889.

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Organophosphorus pyrrolidine derivatives possessing P–N bonds are a promising yet underexplored class of compounds. In this short review we overview the general approaches to these compounds described so far, with a special emphasis on their asymmetric synthesis.1 Introduction2 Synthesis of Pyrrolidine-Based P(III) Derivatives3 Synthesis of Pyrrolidine-Based P(V) Derivatives3.1 Phosphorylation of Pyrrolidines with P(V) Acid Chlorides3.2 Phosphorylation of Pyrrolidines with P(V) Acid Esters3.3 Syntheses via the Atherton–Todd Reaction3.4 Oxidation of Pyrrolidine-Based P(III) Derivatives4 Synthes
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Pfund, Emmanuel, and Thierry Lequeux. "Synthesis of Fluoropyrrolidines and (Fluoroalkyl)pyrrolidines." Synthesis 49, no. 17 (2017): 3848–62. http://dx.doi.org/10.1055/s-0036-1589078.

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Pyrrolidines and their derivatives are of great interest in medicinal chemistry and organic synthesis. Fluoropyrrolidines and (fluoroalkyl)pyrrolidines have been utilized in the preparation of medicinal drugs and also as organocatalysts. The synthesis of such compounds is achieved through the fluorination of pyrrolidine derivatives or by multistep synthesis from already containing fluoroalkyl precursors.1 Introduction1.1 General Interest of Fluorine-Containing Pyrrolidines1.2 Fluoroalkylpyrrolidines and the Gauche Effect2 Fluoropyrrolidines2.1 3-Fluoropyrrolidines2.2 3,3- and 3,4-Difluoropyrro
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Sarbu, Laura Gabriela, Catalin Neculai Lungu, Ion Sandu, Paul Chirita, and Lucian Gabriel Bahrin. "Synthesis of 2-Pyrrolydinyl-1,3-Dithiolium Derivatives from Propiophenones." Revista de Chimie 70, no. 4 (2019): 1311–14. http://dx.doi.org/10.37358/rc.19.4.7116.

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Novel bromo-substituted 4-(2-hydroxyaryl)-5-methyl-2-(pyrrolidin-1-yl)-1,3-dithiol-2-ylium perchlorates have been synthesized by the heterocondensation of the corresponding 1-(2-hydroxyaryl)-1-oxopropan-2-yl dithiocarbamates. The latter compounds have been obtained from the reaction of the corresponding substituted a-bromopropiophenones with pyrrolidinium pyrrolidine-1-carbodithioate. The mesoionic 4-(2-pyrrolidinyl-1,3-dithiol-2-ylium-4-yl)phenolates have been obtained from the corresponding 1,3-dithiolium perchlorates under weak basic conditions. These compounds were characterized by NMR and
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Zubrickė, Irma, Ilona Jonuškienė, Kristina Kantminienė, Ingrida Tumosienė, and Vilma Petrikaitė. "Synthesis and In Vitro Evaluation as Potential Anticancer and Antioxidant Agents of Diphenylamine-Pyrrolidin-2-one-Hydrazone Derivatives." International Journal of Molecular Sciences 24, no. 23 (2023): 16804. http://dx.doi.org/10.3390/ijms242316804.

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The title compounds were synthesized by the reaction of 5-oxo-1-(4-(phenylamino)phenyl)pyrrolidine-3-carbohydrazide with various aldehydes bearing aromatic and heterocyclic moieties and acetophenones, and their cytotoxicity was tested via MTT assay against human triple-negative breast cancer MDA-MB-231, human melanoma IGR39, human pancreatic carcinoma Panc-1, and prostate cancer cell line PPC-1. Furthermore, the selectivity of compounds towards cancer cells compared to fibroblasts was also investigated. Four compounds were identified as the most promising anticancer agents out of a series of p
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Möhrle, Hans, and Johannes Berlitz. "Oxidation 2-substituierter Pyrrolidine und Piperidine als Nicotinanaloga / Oxidation of 2-substituted Pyrrolidines and Piperidines as Nicotine Analogues." Zeitschrift für Naturforschung B 63, no. 8 (2008): 985–92. http://dx.doi.org/10.1515/znb-2008-0811.

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The oxidation of nicotine (1) with Hg(II)-EDTA follows the direction to the α-methylene group of the pyrrolidine part and results in a two-step dehydrogenation to lactam 3. The same course is observed with the aromatic or heteroaromatic 2-substituted compounds 4 - 7 to give the pyrrolidones 8 - 11. In contrast, the 2-methyl- or 2-methylaryl-substituted pyrrolidines 12 - 14 are attacked at the α-methine group with only a two-electron withdrawal and give rise to the iminium derivatives 15 - 17. These salts as well as the corresponding enamines show, after addition of D2O, exchange phenomena in t
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Hou, Qinglin, Yaoyao You, Xinluo Song, Yingxia Wang, Ke Chen та Haifei Wang. "Endo-Selective Construction of Spiro-[butyrolactone-pyrrolidine] via Ag(I)/CAAA-Amidphos-Catalyzed 1,3-Dipolar Cycloaddition between Azomethine Ylides and α-Methylene-γ-Butyrolactone". Catalysts 10, № 1 (2019): 28. http://dx.doi.org/10.3390/catal10010028.

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Construction of spirocyclic pyrrolidines bearing a spiro quaternary stereocenter is an enormous challenge in synthetic organic chemistry. In this report, we introduce a Ag(I)/CAAA-amidphos-catalyzed enantioselective 1,3-dipolar cycloaddition between azomethine ylides and α-methylene-γ-butyrolactone as an effective strategy for the construction of excellent endo-selective spiro-[butyrolactone-pyrrolidine] derivatives. Meanwhile, the catalytic system was also successfully applied in the three-component one-pot reaction of azomethine ylides formed in situ under the action of N,N′-diisopropylcarbo
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Wang, Yali, Jian Xiao, Aiguo Meng, and Chunyan Liu. "Multivalent Pyrrolidine Iminosugars: Synthesis and Biological Relevance." Molecules 27, no. 17 (2022): 5420. http://dx.doi.org/10.3390/molecules27175420.

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Recently, the strategy of multivalency has been widely employed to design glycosidase inhibitors, as glycomimetic clusters often induce marked enzyme inhibition relative to monovalent analogs. Polyhydroxylated pyrrolidines, one of the most studied classes of iminosugars, are an attractive moiety due to their potent and specific inhibition of glycosidases and glycosyltransferases, which are associated with many crucial biological processes. The development of multivalent pyrrolidine derivatives as glycosidase inhibitors has resulted in several promising compounds that stand out. Herein, we comp
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Syal, V. K., U. Becker, R. Elsebrock, and M. Stockhausen. "Dielectric Spectroscopy of Binary Liquid Mixtures of Methanol with Morpholine, Pyrrolidine and some of their Derivatives." Zeitschrift für Naturforschung A 52, no. 8-9 (1997): 675–77. http://dx.doi.org/10.1515/zna-1997-8-921.

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Abstract Dielectric spectra (up to 72 GHz) have been measured at 20 °C for mixtures of methanol and one of the following substances: morpholine, N-methyl morpholine, N-cyano morpholine, pyrrolidine and N-cyano pyrrolidine. The composition dependence of the relaxation parameters shows close similarities for the morpholines and, on the other hand, for the pyrrolidines, which indicates that a structure breaking effect on methanol is exerted by the former but not by the latter group of substances.
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Smolobochkin, Andrey, Almir Gazizov, Nurbol Appazov, Oleg Sinyashin, and Alexander Burilov. "Progress in the Stereoselective Synthesis Methods of Pyrrolidine-Containing Drugs and Their Precursors." International Journal of Molecular Sciences 25, no. 20 (2024): 11158. http://dx.doi.org/10.3390/ijms252011158.

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The presented review systematizes and summarizes the data on the synthesis of pyrrolidine derivatives, which are precursors for obtaining drugs. Based on the analysis of published data, the most promising directions in the synthesis of biologically active compounds containing a pyrrolidine ring are identified. Stereoselective synthesis methods are classified based on the source of the pyrrolidine ring. The first group includes methods that use a pyrrolidine ring as the starting compound. The second group combines stereoselective methods of cyclization of acyclic starting compounds, which lead
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Betti, Nadia A., Redha Ib Hussain, and Sahar Ab Kadhem. "Synthesis of Some New Derivatives of Pyrrolidine-2-one and Studying Their Antibacterial Potentials." Engineering and Technology Journal 38, no. 3B (2020): 128–41. http://dx.doi.org/10.30684/etj.v38i3b.706.

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New derivatives of pyrrolidine-2-one have been synthesized through lactamization of γ –butyrolactone (GBL) by hydrazine hydrate (80%), ethylene diamine and ethanol amine to afford compounds (1-aminopyrrolidin-2-one), (1-(2-aminoethyl)pyrrolidine-2-one) and (1-(2-hydroxyethyl)pyrrolidine-2-one), respectively. Compound (1-aminopyrrolidin-2-one) underwent several reactions to synthesize the rest of these derivatives. All synthesized compounds were approved by their FT-IR, 1H-NMR and some by Mass spectra. The biological activities of these derivatives were evaluated against Escherichia coli and St
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Dissertations / Theses on the topic "Pyrrolidine derivatives"

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Hunter, Darren F. A. "Synthesis of bioactive pyrrolidine and piperidinone derivatives from carbohydrates." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418528.

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Vries, Ton René. "Chiral cyclic derivatives of C2-symmetrical butanedioic acids." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 1996. http://irs.ub.rug.nl/ppn/29767627X.

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Hindle, Neil. "Amino sugars and their glycosides." Thesis, University of Oxford, 1995. http://ora.ox.ac.uk/objects/uuid:78ab400f-4a4c-47bb-9d18-1b3bef205044.

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This thesis describes approaches to the transformation of simple carbohydrates into a polyhydroxylated pyrrolidine and the formation of its glucosides. Chapter one describes the synthesis of the naturally occurring pyrrolidine 2,5-dideoxy-2,5-imino-D-mannitol. Synthesised from di-O-isopropylidene-D-glucose, the key steps are the introduction of nitrogen at C-5 with retention of configuration. Then cyclisation of the nitrogen onto the C-2 position with inversion to form the pyrrolidine ring. Reduction of the aldehyde furnished the polyhydroxylated heterocycle in 3.4% yield over 16 steps. The sy
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Kumar, G. S. "Chemical studies on pyrrolidine derivatives: synthesis of bulgecinine and aminomethyl prolyl peptide nucleic acids." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2006. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2515.

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Ericsson, Cecilia. "Synthesis of Tetrahydrofuran and Pyrrolidine Derivatives Utilising Radical Reactions : Organochalcogenides in Reductive, Carbonylative and Group-Transfer Cyclisation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4018.

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Chaudhry, Humayun Iqbal. "An evaluation of the performance and mechanistic action of the costabiliser N-phenyl-3-acetyl pyrrolidine-2,4-dione and its derivatives in poly(vinyl chloride)." Thesis, Manchester Metropolitan University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311051.

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Eroksuz, Serap. "A New P-fam-silver Catalyst For Asymmetric 1,3-dipolar Cycloaddition Reactions Of Azomethine Ylides." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609801/index.pdf.

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In this study new twelve phosphorus based chiral ligands were synthesized and characterized. Then the catalytic activity of these chiral ligands was tested with Cu(II) and Ag(I) salts in asymmetric 1,3-dipolar cycloaddition reactions of azomethine ylides. This method provides the synthesis of different pyrrolidine derivatives with up to four stereogenic centers. Pyrrolidine derivatives are found in the structure of many biologically active natural compounds and drugs. Therefore the asymmetric synthesis of these compounds is highly important and many groups are involved in this area. As the pre
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Koyuncu, Hasan. "Fam-zinc Catalyzed Asymmetric 1,3-dipolar Cycloaddition Reactions Of Azomethine Ylides And Fam-titanium Catalyzed Enantioselective Alkynylation Of Aldehydes." Phd thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/2/12608783/index.pdf.

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In the first part of this study, four new chiral ligands (FAM) were synthesized and used in catalytic amounts in asymmetric 1,3-dipolar cycloaddition reactions of azomethine ylides. This method leads to the synthesis of chiral pyrrolidines, which are found in the structure of many biologically active natural compounds and drugs. It was found that using 10 mol% of one of these chiral ligands with different dipolarophiles (dimethyl maleate, dimethyl fumarate, methyl acrylate, tert-butyl acrylate, and Nmethylmaleimide), pyrrolidine derivatives could be synthesized in up to 94% yield and 95% ee.
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Corruble, Aline. "Amidures de lithium dérivés de 3-aminopyrrolidines : de nouveaux inducteurs chiraux pour l'alkylation d'aldéhydes par des organolithiens." Rouen, 1997. http://www.theses.fr/1997ROUES007.

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Les amidures de lithium de 3-aminopyrrolidines chirales, synthétisées avec une pureté énantiomérique élevée (>90 %) à partir de la 1-benzyl-3(S)-aminopyrrolidine ou de la 4-hydroxy-(l)-proline, ont été testés comme nouveaux ligands chiraux dans la condensation énantiosélective d'organolithiens sur des aldéhydes aromatiques. L'étude de cette réaction a montré l'importance de l'encombrement du substituant de l'azote en position 3. Ainsi l'excès énantiomérique de l'alcool dérivé de l'ortho-tolualdéhyde et du n-butyllithium passe de 49% avec l'amidure de la 1-benzyl-3-(S)-benzylaminopyrrolidine à
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Chichaoui, Ilhame. "Expériences concernant l'évolution chimique des alcaloïdes : des structures pyridiniques aux structures pyrrolidiniques." Rouen, 1993. http://www.theses.fr/1993ROUES039.

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La majeure partie de ce travail est consacrée à l'étude expérimentale d'une hypothèse concernant l'évolution chimique entre deux classes d'alcaloïdes, les composés pyridiniques et les composés N-méthyl pyrrolidiniques. Le premier chapitre consiste en un rappel bibliographique succinct des expériences de la chimie prébiotique. Dans le deuxième chapitre, est décrite une voie de corrélation en quatre étapes entre les familles de produits naturels étudiés. Cette synthèse est basée sur la chimie des énamines hétérocycliques et des sels d'iminiums α bromés correspondants. Le composé pyridinique init
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Books on the topic "Pyrrolidine derivatives"

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Cavanna, Andrea E. Levetiracetam, piracetam, and brivaracetam. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198791577.003.0008.

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Levetiracetam is a third-generation antiepileptic drug characterized by a wide range of antiepileptic indications, with a very good interaction profile in polytherapy. Levetiracetam has an acceptable behavioural tolerability profile, but limited potential for psychiatric uses. Behavioural adverse events (irritability and emotional lability) are often reported by patients with epilepsy taking levetiracetam; psychotic symptoms and episodes of severe aggression have occasionally been reported. Initial reports suggesting a possible role for levetiracetam in the treatment of bipolar depression and
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Book chapters on the topic "Pyrrolidine derivatives"

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Faigl, F., E. Kovács, G. Turczel, et al. "Novel Methods for the Stereoselective Synthesis of Oxetane, Azetidine and Pyrrolidine Derivatives." In IFMBE Proceedings. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-23508-5_352.

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Matsuyama, Kenji, Choichiro Miyazaki, and Masataka Ichikawa. "Development of a Pyrrolidinone Derivative (Cyclic GABA) for Modulating Brain Glutamate Transmission." In Advances in Behavioral Biology. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5727-8_17.

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Kojima, Hiroshi, Shinichi Kawajiri, Takeo Sakurai, and Terukiyo Yamasaki. "Effect of DM-9384, a New Pyrrolidone Derivative, on Passive Avoidance and Cerebral Choline Acetyltransferase Activity in Rats." In Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5847-3_74.

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Kameyama, Tsutomu, Toshitaka Nabeshima, Keiko Tohyama, Shin-ichi Ogawa, Kenshi Murase, and Sei-ichi Ishihara. "Dm-9384, a Pyrrolidone Derivative, Ameliorates Basal Forebrain Lesion-Induced Amnesia and Inhibits Cycloheximide-Induced Decrease in the Number of GABA and Acetylcholine Receptors." In Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5847-3_75.

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Fellows, Linda E., Geoffrey C. Kite, Robert J. Nash, Monique S. J. Simmonds, and Anthony M. Scofield*. "Distribution and biological activity of alkaloidal glycosidase inhibitors from plants." In Nitrogen Metabolism of Plants. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780198577522.003.0016.

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Abstract Alkaloidal glycosidase inhibitors (AG Is), which have been reported to occur in many species of higher plants, bacteria and fungi, are probably widespread in nature. They belong to five different chemical structural types, namely polyhydroxylated derivatives of piperidine, pyrrolidine, pyrroline, octahydroindolizine, and pyrrolizidine. Certain of the simpler piperidine and pyrrolidine derivatives bear an obvious structural resemblance to 1-deoxy monosaccharides, with the ring oxygen replaced by nitrogen. The orientation of hydroxy groups on the more complex bicyclic structures also su
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Raissi, Hanen, Imen Chérif, Hajer Ayachi, et al. "Structure-Property Relationships in Benzofurazan Derivatives: A Combined Experimental and DFT/TD-DFT Investigation." In Density Functional Theory - Recent Advances, New Perspectives and Applications [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.99246.

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In this work we seek to understand and to quantify the reactivity of benzofurazan derivatives toward secondary cyclic amines, like pyrrolidine, piperidine and morpholine, acting as nucleophile groups in SNAr reactions. For this aim, physico-chemical and structural descriptors were determined experimentally and theoretically using the DFT/B3LYP/6-31+ g (d,p) methodology. Thus, different 4-X-7-nitrobenzofurazans (X = OCH3, OC6H5 and Cl) and products corresponding to the electrophilic aromatic substitution by pyrrolidine, piperidine and morpholine, were investigated. Particularly, the HOMO and LU
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Taber, Douglass F. "C–N Ring Construction: The Fujii/Ohno Synthesis of (–)-Quinocarcin." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0056.

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Tsutomu Katsuki of Kyushu University devised (Org. Lett. 2012, 14, 4658) a Ru catalyst for the enantioselective aziridination of vinyl ketones such as 1. David W.C. MacMillan of Princeton University added (J. Am. Chem. Soc. 2012, 134, 11400) 3 to the alkene 4 under single electron conditions to give 5 with high stereocontrol. Barry M. Trost of Stanford University effected (J. Am. Chem. Soc. 2012, 134, 4941) the Pd-catalyzed addition of 7 to an imine 6 to give the pyrrolidine 8. More recently, he used (J. Am. Chem. Soc. 2013, 135, 2459) this approach to construct pyrrolidines containing defined
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Christie, William W. "Mass spectrometry of fatty acid derivatives." In Applications of Modern Mass Spectrometry in Plant Science Research. Oxford University PressOxford, 1996. http://dx.doi.org/10.1093/oso/9780198549659.003.0013.

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Abstract The potential of mass spectrometry (MS) for the identification of fatty acids of natural origin has been evident for many years. However, until relatively recently there were few reports of structural analyses on real samples containing unsaturated fatty acids as opposed to model compounds. The topic has been the subject of several reviews (Minnikin 1978; Schmitz and Klein 1986; Jensen and Gross 1987; Murphy 1993). The main problem has been the location of double bonds, although there have also been difficulties with ring structures or branch-points. There are three general approaches
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Taber, Douglass. "New Methods for the Stereoselective Construction of N-Containing Rings." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0053.

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Several methods have been reported for the stereocontrolled preparation of pyrrolidine and piperidine derivatives. Alison J. Frontier of the University of Rochester has observed (Organic Lett. 2007, 9, 4939) that hydrogenation of acyl pyrroles such as 1 gave good control not just around the ring, but also on the sidechain. Chi-Ming Che of the University of Hong Kong has devised ( J. Am. Chem. Soc. 2007, 129, 5828) a catalyst that converted amides such as 3 into the cyclized product 4, also with high diastereocontrol. Jean Ollivier of the Université de Paris-Sud, following the Sato procedure, h
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Geidel, E., K. Krause, J. Kindler, and H. Förster. "Exploring the sites of adsorbed pyrrolidine derivatives in Y zeolites by joined infrared spectroscopic and computer simulation studies." In Studies in Surface Science and Catalysis. Elsevier, 1997. http://dx.doi.org/10.1016/s0167-2991(97)80603-9.

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Conference papers on the topic "Pyrrolidine derivatives"

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A.V., Firsova, Polovinkina M.A., Grigoriev V.A., Osipova V.P., and Kudryavtsev K.V. "EFFECT OF NEW PHENOL DERIVATIVES WITH PYRROLIDINE FRAGMENT ON THE REPRODUCTIVE PROPERTIES OF STURGEON GAMETES." In II INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE "DEVELOPMENT AND MODERN PROBLEMS OF AQUACULTURE" ("AQUACULTURE 2022" CONFERENCE). DSTU-Print, 2022. http://dx.doi.org/10.23947/aquaculture.2022.154-156.

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The influence of new phenolic derivatives of pyrrolidine on the quality of native sturgeon sperm and on the fertility of eggs was assessed in comparison with the well-known antioxidant - ionol. The high efficiency of (L)-1-(2-((1-hydroxynaphthalen-2-yl)thio)acetyl)pyrrolidine-2-carboxylic acid was shown, the addition of this compound increases the time of forward movement of spermatozoa by 2.2 times relative to the control and an increase in the percentage of fertilization and hatching of prelarvae by about 1.5 times. The results obtained indicate the need for additional studies to establish t
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Rinnová, Markéta, and Ivan Rosenberg. "3'-N-phosphonomethyl derivatives of pyrrolidine nucleosides related to L-nucleotides." In XIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199902060.

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Rejman, Dominik, and Radek Pohl. "Synthesis of PME derivatives of nucleobases with conformation locked via pyrrolidine ring." In XVth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112446.

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Половинкина, М. А., В. П. Осипова, Е. Н. Пономарева, К. В. Кудрявцев, and А. В. Великородов. "INFLUENCE OF NEW PHENOLIC DERIVATIVES ON FISH-BREEDING PARAMETERS OF FERTILIZED STERLET CAVIAR." In DEVELOPMENT AND MODERN PROBLEMS OF AQUACULTURE. ООО "ДГТУ-Принт" Адресс полиграфического предприятия 344003 пл Гагарина, зд. 1, 2023. http://dx.doi.org/10.23947/aquaculture.2023.94-97.

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The effect of shielded phenol derivatives in comparison with the water-soluble analog of vitamin E – Trolox, on the activity of sterlet sperm and on the fish-breeding indicators of fertilized sterlet eggs before the cryopreservation process was studied in this work. A positive effect of (L)-1-(2-((1-hydroxyphenyl)thio)acetin)pyrrolidine-2-carboxylic acid on sperm activity indicators has been established, which is expressed in an increase in the proportion of living cells and their lifetime. Evaluation of fish-breeding indicators of sterlet reproductive caviar indicates a greater survival rate
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V.P., Osipova, and Kolyada M.N. "APPLICATION OF NEW GENERATION ANTIOXIDANTS AS CRYOPROTECTORS IN LOWTEMPERATURE PRESERVATION OF STURGEON REPRODUCTIVE CELLS." In II INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE "DEVELOPMENT AND MODERN PROBLEMS OF AQUACULTURE" ("AQUACULTURE 2022" CONFERENCE). DSTU-Print, 2022. http://dx.doi.org/10.23947/aquaculture.2022.103-105.

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The paper presents the results of a study of the cryoprotective activity of a new generation of antioxidants – hybrid multifunctional phenolic derivatives during low-temperature preservation of sturgeon reproductive cells. It has been shown that the addition of phosphorus-containing sterically hindered phenol, pyrrolidine and thioacetamide phenolic derivatives to the basic modified Stein cryoprotective medium, makes it possible to increase the low cryoresistance of sturgeon sperm: the level of lipid peroxidation decreases, cell motility improves, and the fertility of defrosted sperm increases.
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Vongsaysy, Uyxing, Bertrand Pavageau, Laurent Servant, and Hany Aziz. "Pyrrolidinone derivatives as processing additives for solution processed organic solar cells." In SPIE Organic Photonics + Electronics, edited by Zakya H. Kafafi, Paul A. Lane, and Ifor D. W. Samuel. SPIE, 2014. http://dx.doi.org/10.1117/12.2061381.

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Rizbayeva, T., A. Smolobochkin, A. Gazizov, A. Burilov, and M. Pudovik. "THE INTERACTION OF 4,4-DIETHOXYBUTAN-1-AMINE DERIVATIVES WITH C-NUCLEOPHILES. SYNTHESIS OF NOVEL 2-SUBSTITUTED PYRROLIDINES." In Chemistry of nitro compounds and related nitrogen-oxygen systems. LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m751.aks-2019/197-198.

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