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Dissertations / Theses on the topic 'Pyrrolidine derivatives'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Hunter, Darren F. A. "Synthesis of bioactive pyrrolidine and piperidinone derivatives from carbohydrates." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418528.

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2

Vries, Ton René. "Chiral cyclic derivatives of C2-symmetrical butanedioic acids." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 1996. http://irs.ub.rug.nl/ppn/29767627X.

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3

Hindle, Neil. "Amino sugars and their glycosides." Thesis, University of Oxford, 1995. http://ora.ox.ac.uk/objects/uuid:78ab400f-4a4c-47bb-9d18-1b3bef205044.

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This thesis describes approaches to the transformation of simple carbohydrates into a polyhydroxylated pyrrolidine and the formation of its glucosides. Chapter one describes the synthesis of the naturally occurring pyrrolidine 2,5-dideoxy-2,5-imino-D-mannitol. Synthesised from di-O-isopropylidene-D-glucose, the key steps are the introduction of nitrogen at C-5 with retention of configuration. Then cyclisation of the nitrogen onto the C-2 position with inversion to form the pyrrolidine ring. Reduction of the aldehyde furnished the polyhydroxylated heterocycle in 3.4% yield over 16 steps. The sy

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4

Kumar, G. S. "Chemical studies on pyrrolidine derivatives: synthesis of bulgecinine and aminomethyl prolyl peptide nucleic acids." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2006. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2515.

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5

Ericsson, Cecilia. "Synthesis of Tetrahydrofuran and Pyrrolidine Derivatives Utilising Radical Reactions : Organochalcogenides in Reductive, Carbonylative and Group-Transfer Cyclisation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4018.

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6

Chaudhry, Humayun Iqbal. "An evaluation of the performance and mechanistic action of the costabiliser N-phenyl-3-acetyl pyrrolidine-2,4-dione and its derivatives in poly(vinyl chloride)." Thesis, Manchester Metropolitan University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311051.

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7

Eroksuz, Serap. "A New P-fam-silver Catalyst For Asymmetric 1,3-dipolar Cycloaddition Reactions Of Azomethine Ylides." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609801/index.pdf.

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In this study new twelve phosphorus based chiral ligands were synthesized and characterized. Then the catalytic activity of these chiral ligands was tested with Cu(II) and Ag(I) salts in asymmetric 1,3-dipolar cycloaddition reactions of azomethine ylides. This method provides the synthesis of different pyrrolidine derivatives with up to four stereogenic centers. Pyrrolidine derivatives are found in the structure of many biologically active natural compounds and drugs. Therefore the asymmetric synthesis of these compounds is highly important and many groups are involved in this area. As the pre

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8

Koyuncu, Hasan. "Fam-zinc Catalyzed Asymmetric 1,3-dipolar Cycloaddition Reactions Of Azomethine Ylides And Fam-titanium Catalyzed Enantioselective Alkynylation Of Aldehydes." Phd thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/2/12608783/index.pdf.

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In the first part of this study, four new chiral ligands (FAM) were synthesized and used in catalytic amounts in asymmetric 1,3-dipolar cycloaddition reactions of azomethine ylides. This method leads to the synthesis of chiral pyrrolidines, which are found in the structure of many biologically active natural compounds and drugs. It was found that using 10 mol% of one of these chiral ligands with different dipolarophiles (dimethyl maleate, dimethyl fumarate, methyl acrylate, tert-butyl acrylate, and Nmethylmaleimide), pyrrolidine derivatives could be synthesized in up to 94% yield and 95% ee.

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9

Corruble, Aline. "Amidures de lithium dérivés de 3-aminopyrrolidines : de nouveaux inducteurs chiraux pour l'alkylation d'aldéhydes par des organolithiens." Rouen, 1997. http://www.theses.fr/1997ROUES007.

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Les amidures de lithium de 3-aminopyrrolidines chirales, synthétisées avec une pureté énantiomérique élevée (>90 %) à partir de la 1-benzyl-3(S)-aminopyrrolidine ou de la 4-hydroxy-(l)-proline, ont été testés comme nouveaux ligands chiraux dans la condensation énantiosélective d'organolithiens sur des aldéhydes aromatiques. L'étude de cette réaction a montré l'importance de l'encombrement du substituant de l'azote en position 3. Ainsi l'excès énantiomérique de l'alcool dérivé de l'ortho-tolualdéhyde et du n-butyllithium passe de 49% avec l'amidure de la 1-benzyl-3-(S)-benzylaminopyrrolidine à

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10

Chichaoui, Ilhame. "Expériences concernant l'évolution chimique des alcaloïdes : des structures pyridiniques aux structures pyrrolidiniques." Rouen, 1993. http://www.theses.fr/1993ROUES039.

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La majeure partie de ce travail est consacrée à l'étude expérimentale d'une hypothèse concernant l'évolution chimique entre deux classes d'alcaloïdes, les composés pyridiniques et les composés N-méthyl pyrrolidiniques. Le premier chapitre consiste en un rappel bibliographique succinct des expériences de la chimie prébiotique. Dans le deuxième chapitre, est décrite une voie de corrélation en quatre étapes entre les familles de produits naturels étudiés. Cette synthèse est basée sur la chimie des énamines hétérocycliques et des sels d'iminiums α bromés correspondants. Le composé pyridinique init

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11

Park, Saerom [Verfasser], та Oliver [Akademischer Betreuer] Reiser. "Studies on Reactions of Cyclopropanated Pyrrole: Synthesis of Bis-β-homoproline, Tropane- and Pyrrolidinone-derivatives / Saerom Park ; Betreuer: Oliver Reiser". Regensburg : Universitätsbibliothek Regensburg, 2020. http://d-nb.info/1211556581/34.

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12

Icard, Béatrice. "Approches des mécanismes physiques de formation des membranes polymères asymétriques : RMN et vidéomicroscopie." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10113.

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Ce travail concerne la formation de la porosite dans les membranes polymeres asymetriques elaborees par procede de coagulation. Les membranes ainsi formees admettent une couche dense supportee par une sous-couche poreuse. La derniere est constituee de pores connectes de taille micrometrique et parfois de macropores dont la taille est dix fois superieure. Ces macrovides a forme de goutte allongee sont appeles doigts de gant. Le controle de la formation de cette porosite est un enjeu industriel important car elle fragilise la couche dense. L'etude s'applique essentiellement au systeme ternaire c

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13

Husmann, Ralph [Verfasser]. "Synthesis and application of silylated pyrrolidines enantioselective organocatalytic synthesis of a-trifluoromethyl a-amino acid derivatives and copper-catalyzed multicomponent reactions / Ralph Husmann." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2011. http://d-nb.info/1018190465/34.

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14

張元軍. "Synthesis of N-alkyl Iminoalditol and pyrrolidine derivatives as Glycosidase Inhibitors." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/83759606820380930634.

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碩士<br>國立彰化師範大學<br>化學系<br>97<br>The goals of our research are to synthesize glycosidase inhibitors. The first project is using D-ribose as starting material to synthesize the derivatives of ribopyranoside. We are successful to obtain the target compound methyl 2-C-(5-deoxy-2,3-di-O-isopropylidene-5 morpholinopropylamino-β-D-ribopyranosyl) acetate 7, methyl 2-C-(5-deoxy-2,3-di-O-isopropylidene-5-decylamino-β-Dribopyranosyl) acetate 9, 2-C-(5-deoxy-2,3-di-O-isopropylidene-5-morpholinopropyl amino-β-D-ribopyranosyl)ethanol 8, and 2-C-(5-deoxy-2,3-di-O-isopropylidene-5- decylamino -β-D-ribopyranosy

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15

Braithwaite, Dana Helen. "New methodology for the synthesis of chiral pyrrolidine derivatives from monosaccharides." Thesis, 2014. http://hdl.handle.net/10210/10144.

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M.Sc. (Chemistry)<br>The aim of this study waa to develop new methodology for the synthesis of chiral pyrrolidine derivatives Crom monosaccharides. An overview of the stereoselectlve synthesis of pyrrolldlnes as precursors of natural compounds 11 given, as well as a summary ,of their uses in the synthesis of two groups of biologically active natural compounds and their analogues. A synthetic approach towards a pyrrolidine synthon for an ll-a.za-PG was investigated by means of stereoselective and stereospecific reactions. The ability to incorporate an N-O linkage into the synthon to allow the s

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16

Chih-WeiKo and 柯志威. "Cobalt-Catalyzed Carbon−Carbon Bond Formation: Synthesis and Applications of Enantiopure Pyrrolidine Derivatives." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/25480682267044486358.

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17

Huang, Yu-Chao, and 黃昱超. "The Study on Asymmetric Addition Reaction Catalyzed by Camphorsulfonamide-derived-amine and Pyrrolidine–camphorsulfonamide Derivatives." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/rm8sw7.

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博士<br>國立清華大學<br>化學系<br>102<br>This thesis deals with the application of camphor-derived organocatalyst in asymmetric addition reaction. The fisrt part discusses the asymmetric aldol reaction of 2,2-dimethyl-1,3-dioxan-5-one with aldehydes in the presence of 10 mol% organocatalyst 42 and 20 mol% p-nitrobenzoic acid to give aldol products in good yields with high enatio- and diastereoselectivities. (up to 99% ee, 4:96 dr) The second part deals with the development of camphorsulfonamdie-derived (2S,4R)-4-hydroxy-L-prolinamide 54b as organocatalyst. Catalyst 54b is able to catalyze asymmetric Mi

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18

Teesdale-Spittle, P. H., Klaus Pors, R. Brown, Laurence H. Patterson, and J. A. Plumb. "Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells." 2005. http://hdl.handle.net/10454/3191.

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No<br>A novel series of 1,4-disubstituted aminoanthraquinones were prepared by ipso-displacement of 1,4-difluoro-5,8-dihydroxyanthraquinones by hydroxylated piperidinyl- or pyrrolidinylalkyl-amino side chains. One aminoanthraquinone (13) was further derivatized to a chloropropyl-amino analogue by treatment with triphenylphosphine-carbon tetrachloride. The compounds were evaluated in the A2780 ovarian cancer cell line and its cisplatin-resistant variants (A2780/ cp70 and A2780/MCP1). The novel anthraquinones were shown to possess up to 5-fold increased potency against the cisplatin-resistant ce

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19

YANG, TING-HSUANG, and 楊庭軒. "Design, Synthesis and Evaluation of Novel 2-Pyrrolidone-Fused (2-Oxoindolin-3-ylidene)methylpyrrole Derivatives as Potential Anti-angiogenesis Agents." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/sn5639.

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博士<br>國防醫學院<br>醫學科學研究所<br>106<br>Signaling pathways of VEGFs and PDGFs are crucial in tumor angiogenesis, which is essential in solid tumor progression and metastasis. This study reports our strategy for design and synthesis of a series of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential multi-target tyrosine kinase receptor inhibitors. The target compounds were obtained by condensation of 5-substituted oxindoles with N-substituted 2-pyrrolidone aldehyde 7 in satisfactory yields. Of these, 11, 12, 23 and 24 had the highest potency and, compared to suniti

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