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Relevant bibliographies by topics / Pyrrolizidine alkaloid

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Academic literature on the topic 'Pyrrolizidine alkaloid'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Pyrrolizidine alkaloid"

1

Nickisch-Rosenegk, Eva von, Dietrich Schneider, and Michael Wink. "Time-Course of Pyrrolizidine Alkaloid Processing in the Alkaloid Exploiting Arctiid Moth, Creatonotos transiens." Zeitschrift für Naturforschung C 45, no. 7-8 (1990): 881–94. http://dx.doi.org/10.1515/znc-1990-7-822.

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Abstract The processing of dietary pyrrolizidine alkaloids by larvae and adults of the arctiid moth Creatonotos transiens was studied in time-course experiments: In larvae, pyrrolizidine alkaloid uptake is quickly followed by the transformation of the alkaloids into their N-oxides. Further- more, if 7 S-heliotrine is applied, a stereochemical inversion of the hydroxyl group at C 7 to 7 R-heliotrine can be observed within 48 h of feeding. The rate of this biotransformation is substantially higher in males which use the 7 R-form later as a precursor for the biosynthesis of 7 R-hydroxydanaidal, a

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Kopp, Thomas, Mona Abdel-Tawab, and Boris Mizaikoff. "Core Imprinting: An Alternative and Economic Approach for Depleting Pyrrolizidine Alkaloids in Herbal Extracts." Planta Medica International Open 7, no. 01 (2020): e26-e33. http://dx.doi.org/10.1055/a-1121-4868.

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AbstractDue to the high toxicity of pyrrolizidine alkaloids, in 2011, the German Federal Institute of Risk Assessment recommended that their daily intake limit should be no more than 0.007 µg/kg body weight. The risk of ingesting these substances in herbal preparations, either from their inherent presence in plants or through contamination with pyrrolizidine alkaloid-containing weeds, should not be underestimated. A promising molecular imprinted polymer was developed previously to minimise exposure to these compounds. Due to the high costs of the template and the risk of template bleeding, an

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Kopp, Thomas, Mona Abdel-Tawab, Martin Khoeiklang, and Boris Mizaikoff. "Development of a Selective Adsorbing Material for Binding of Pyrrolizidine Alkaloids in Herbal Extracts, Based on Molecular Group Imprinting." Planta Medica 85, no. 13 (2019): 1107–13. http://dx.doi.org/10.1055/a-0961-2658.

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AbstractPyrrolizidine alkaloids are secondary plant constituents that became a subject of public concern because of their hepatotoxic, pneumotoxic, genotoxic, and cytotoxic effects. Due to disregardful harvesting and/or contamination with pyrrolizidine alkaloid-containing plants, there is a high risk of ingesting these substances with plant extracts or natural products. The limit for the daily intake was set to 0.007 µg/kg body weight. If contained in an extract, cleanup methods may help to minimize the pyrrolizidine alkaloid concentration. For this purpose, a material for depleting pyrrolizid

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Kopp, Thomas, Liesa Salzer, Mona Abdel-Tawab, and Boris Mizaikoff. "Efficient Extraction of Pyrrolizidine Alkaloids from Plants by Pressurised Liquid Extraction – A Preliminary Study." Planta Medica 86, no. 01 (2019): 85–90. http://dx.doi.org/10.1055/a-1023-7419.

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AbstractPyrrolizidine alkaloids and their corresponding pyrrolizidine alkaloid-N-oxides are secondary plant constituents that became the subject of public concern due to their hepatotoxic, pneumotoxic, genotoxic, and cytotoxic effects. In contrast to the well-established analytical separation and detection methods, only a few studies have investigated the extraction of pyrrolizidine alkaloids/pyrrolizidine alkaloid-N-oxides from plant material. In this study, we have applied pressurized liquid extraction with the aim of evaluating the effect of various parameters on the recovery of pyrrolizidi

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El-Shazly, Assem. "Pyrrolizidine Alkaloid Profiles of Some Senecio Species from Egypt." Zeitschrift für Naturforschung C 57, no. 5-6 (2002): 429–33. http://dx.doi.org/10.1515/znc-2002-5-604.

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Alkaloid profiles of two Egyptian Senecio species (Senecio aegyptius var. discoideus and S. desfontainei) in addition to a cultivated species (S. cineraria) were studied using capillary GLC and GLC-mass spectrometry with respect to pyrrolizidine alkaloids (PAs). Four alkaloids were identified in S. aegyptius var. discoideus, 8 in S. desfontainei and 13 in S. cineraria. Some of these alkaloids have not been reported from these plants. The alkaloidal pattern of different plant organs (flowers, leaves, stem, root) were also investigated. Senecionine has been found to be a one of the major alkaloi

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Edgar, J. A., H. J. Lin, C. R. Kumana, and M. M. T. Ng. "Pyrrolizidine Alkaloid Composition of Three Chinese Medicinal Herbs, Eupatorium cannabinum, E. japonicum and Crotalaria assamica." American Journal of Chinese Medicine 20, no. 03n04 (1992): 281–88. http://dx.doi.org/10.1142/s0192415x92000291.

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The pyrrolizidine alkaloid composition of three Chinese herbs, "pei lan", "cheng gan cao" and "zi xiao rong" identified respectively as Eupatorium cannabinum, Eupatorium japonicum (Compositae) and Crotalaria assamica (Leguminosae), were studied by fast atom bombardment mass spectrometry and gas chromatography-electron impact mass spectrometry. Viridiflorine, cynaustraline, amabiline, supinine, echinatine, rinderine and isomers of these alkaloids were found in the Eupatorium species. Monocrotaline was the only pyrrolizidine alkaloid detected in the Crotalaria species.

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Lin, Ge, and Mengbi Yang. "Biotransformation of Pyrrolizidine alkaloid N-Oxide to hepatotoxic Pyrrolizidine alkaloid." Drug Metabolism and Pharmacokinetics 34, no. 1 (2019): S58—S59. http://dx.doi.org/10.1016/j.dmpk.2018.09.205.

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8

Hungerford, Natasha L., Steve J. Carter, Shalona R. Anuj, et al. "Analysis of Pyrrolizidine Alkaloids in Queensland Honey: Using Low Temperature Chromatography to Resolve Stereoisomers and Identify Botanical Sources by UHPLC-MS/MS." Toxins 11, no. 12 (2019): 726. http://dx.doi.org/10.3390/toxins11120726.

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Pyrrolizidine alkaloids (PAs) are a diverse group of plant secondary metabolites with known varied toxicity. Consumption of 1,2-unsaturated PAs has been linked to acute and chronic liver damage, carcinogenicity and death, in livestock and humans, making their presence in food of concern to food regulators in Australia and internationally. In this survey, honey samples sourced from markets and shops in Queensland (Australia), were analysed by high-resolution Orbitrap UHPLC-MS/MS for 30 common PAs. Relationships between the occurrence of pyrrolizidine alkaloids and the botanical origin of the ho

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Chen, Xue-Peng, Lie-Feng Ma, and Zha-Jun Zhan. "A New Pyrrolizidine Alkaloid from Penicillium Expansum." Journal of Chemical Research 41, no. 2 (2017): 93–94. http://dx.doi.org/10.3184/174751917x14858862342142.

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A new pyrrolizidine alkaloid with an unusual O-bridge, named penexpandine, was isolated from the cultures of Penicillium expansum ACCC 30904, together with two known alkaloids, communesins A and B. The structure of the new compound was established by detailed analyses of the spectroscopic data, especially 1D- and 2D-NMR and HR-ESI-MS

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Chizzola, Remigius. "Pyrrolizidine Alkaloids in Adenostyles alliariae and A. glabra from the Austrian Alps." Natural Product Communications 10, no. 7 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000710.

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The alkaloid content of Adenostyles alliariae and A. glabra (Asteraceae) has been evaluated. Both species contain toxic macrocyclic unsaturated pyrrolizidine alkaloids with seneciphylline as the main compound accounting for more than 90% of the alkaloid fraction in all above ground plant parts. Further alkaloids were spartioidine, acetyl-senciphylline and senecionine. Inflorescences showed the highest alkaloid contents with 21.1 and 13.4 mg/g in A. alliariae and A. glabra, respectively. Stems and leaves had 2–3 times lower contents. Therefore, these Adenostyles species must be considered as hi

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Dissertations / Theses on the topic "Pyrrolizidine alkaloid"

1

Fortune, Grady Thomas Jr. "Structure-activity relationships in semisynthetic pyrrolizidine alkaloid antitumor agents." Diss., Georgia Institute of Technology, 1989. http://hdl.handle.net/1853/27371.

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Faulkner, Jerome Ralph. "INTERMEDIATE STEPS OF LOLINE ALKALOID BIOSYNTHESIS." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/209.

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Epichloë species and their anamorphs, Neotyphodium species, are fungal endophytes that inhabit cool-season grasses and often produce bioprotective alkaloids. These alkaloids include lolines, which are insecticidal and insect feeding deterrents. Lolines are exo-1-aminopyrrolizidines with an oxygen bridge between carbons 2 and 7, and are usually methylated and formylated or acetylated on the 1-amine. In previously published studies lolines were shown to be derived from the amino acids L-proline and L-homoserine. In addition the gene cluster involved in loline-alkaloid biosynthesis has also been

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Fleischmann, Thomas John. "Semisynthetic pyrrolizidine alkaloid antitumor agents and the toxic component of eupatorium rugosum." Diss., Georgia Institute of Technology, 1987. http://hdl.handle.net/1853/30343.

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Bhardwaj, Minakshi. "FORMATION OF THE ETHER BRIDGE IN THE LOLINE ALKALOID BIOSYNTHETIC PATHWAY." UKnowledge, 2017. http://uknowledge.uky.edu/chemistry_etds/75.

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Lolines are specialized metabolites produced by endophytic fungi, such as Neotyphodium and Epichloë species, that are in symbiotic relationships with cool-season grasses. Lolines are vital for the survival of the grasses because their insecticidal and antifeedant properties protect the plant from insect herbivory. Although lolines have various bioactivities, they do not have any concomitant antimammalian activities. Lolines have complex structures that are unique among naturally occurring pyrrolizidine alkaloids. Lolines have four contiguous stereocenters, and they contain an ether bridge conn

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Davis, Jonathan C. "Section one : photochemical methodologies towards the pyrrolizidine and indolizidine alkaloid skeleta; section two; synthesis of novel leukotriene photoaffinity labels." Thesis, University of Reading, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360717.

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Kruse, Lars Hendrik [Verfasser], Dietrich [Akademischer Betreuer] Ober, and Axel [Gutachter] Scheidig. "A multifaceted approach to identify unknown enzymes of pyrrolizidine alkaloid biosynthesis / Lars Hendrik Kruse ; Gutachter: Axel Scheidig ; Betreuer: Dietrich Ober." Kiel : Universitätsbibliothek Kiel, 2017. http://d-nb.info/1210925060/34.

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Kruse, Lars Hendrik Verfasser], Dietrich [Akademischer Betreuer] [Ober, and Axel [Gutachter] Scheidig. "A multifaceted approach to identify unknown enzymes of pyrrolizidine alkaloid biosynthesis / Lars Hendrik Kruse ; Gutachter: Axel Scheidig ; Betreuer: Dietrich Ober." Kiel : Universitätsbibliothek Kiel, 2017. http://nbn-resolving.de/urn:nbn:de:gbv:8-diss-211136.

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8

Dener, Jeffrey Mark. "Part I, the enantioselective synthesis of pyrrolizidine alkaloids using alpha-acylamino radical cyclizations ; Part II, the enantioselective synthesis of the indolizidine alkaloid (-)-swainsonine using an alpha-acylamino radical cyclization /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487591658176567.

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9

Vevers, William F. "Deoxynivalenol : toxicological profile and potential for reducing cereal grain contamination using bacterial additives in fermented animal feed." Thesis, University of Plymouth, 2015. http://hdl.handle.net/10026.1/4305.

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Deoxynivalenol (DON) contamination of grain destined for animal feeds is a major toxicological risk to monogastrics and is suspected of restricting productivity in ruminants. Whereas bacterial additives have been developed that can detoxify DON in the rumen and lower intestine, there are currently no commercial inoculants able to perform this task in crimped grain (CG) silage, a regionally important method of moist grain preservation based on homo- and heterofermentative lactic acid bacteria or chemical additives. Determining whether this ensiling process alongside the action of detoxifying ba

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Choi, Joong-Kwon. "Synthesis of pyrrolizidine alkaloids /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487259125219504.

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Books on the topic "Pyrrolizidine alkaloid"

1

Chemistry and toxicology of pyrrolizidine alkaloids. Academic Press, 1986.

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2

Hol, Wilhelmina Hermina Geertruida. The role of pyrrolizidine alkaloids from Senecio jacobaea in the defence against fungi. Universiteit Leiden, 2003.

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3

Máčel, Mirka. On the evolution of the diversity of pyrrolizidine alkaloids: The role of insects as selective forces. Universiteit Leiden, 2003.

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4

Deyo, James A. Immunotoxicity of the pyrrolizidine alkaloid monocrotaline in C57B1/6 mice. 1991.

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5

Chung, Woon-Gye. Comparative metabolism of the pyrrolizidine alkaloid senecionine in rat and guinea pig. 1993.

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6

Gray, Diane R. Bacterial 16S ribosomal DNA analysis of pyrrolizidine alkaloid detoxifying enrichments from the ovine rumen. 1998.

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7

World Health Organization (WHO). Pyrrolizidine Alkaloids. World Health Organization, 1988.

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Pyrrolizidine alkaloids. World Health Organization, 1988.

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M, Rizk A., ed. Naturally occurring pyrrolizidine alkaloids. CRC Press, 1991.

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Pyrrolizidine Alkaloids Health and Safety Guide. World Health Organization, 1989.

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Book chapters on the topic "Pyrrolizidine alkaloid"

1

Neuman, Manuela G. "Pyrrolizidine Alkaloid-Induced Toxicity to the Liver." In Natural Products. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_92.

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Buhler, Donald R., Cristobal L. Miranda, Bogdan Kedzierski, and Ralph L. Reed. "Mechanisms for Pyrrolizidine Alkaloid Activation and Detoxification." In Advances in Experimental Medicine and Biology. Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4684-5877-0_75.

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Bober, Mary A., Mark J. Kurth, Larry A. Milco, David M. Roseman, R. Bryan Miller, and Henry J. Segal. "A Pyrrolizidine Alkaloid Enzyme-Linked Immunosorbent Assay Detection Strategy." In ACS Symposium Series. American Chemical Society, 1990. http://dx.doi.org/10.1021/bk-1990-0451.ch016.

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Ralphs, M. H., and D. N. Ueckert. "Other Toxic Pyrrolizidine Alkaloid-Containing Plants: Importance, Distribution, and Control." In Noxious Range Weeds. CRC Press, 2021. http://dx.doi.org/10.1201/9780429046483-43.

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Huxtable, R. J., R. Bowers, A. R. Mattocks, and M. Michnicka. "Sulfur Conjugates as Putative Pneumotoxic Metabolites of the Pyrrolizidine Alkaloid, Monocrotaline." In Advances in Experimental Medicine and Biology. Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4684-5877-0_76.

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Yan, Chong Chao, and Ryan J. Huxtable. "Effect of Taurine on Toxicity of the Pyrrolizidine Alkaloid Monocrotaline in Rats." In Advances in Experimental Medicine and Biology. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-0182-8_33.

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de Boer, Nico J. "Pyrrolizidine alkaloid distribution in Senecio jacobaea rosettes minimises losses to generalist feeding." In Proceedings of the 10th International Symposium on Insect-Plant Relationships. Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-017-1890-5_21.

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Hasal, Steve J., Yun Sun, Chong Chao Yan, Klaus Brendel, and Ryan J. Huxtable. "Effects of Taurine in Precision-Cut Liver Slices Exposed to the Pyrrolizidine Alkaloid, Retrorsine." In Advances in Experimental Medicine and Biology. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4899-0117-0_10.

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Sun, Y., S. J. Hasal, C. C. Yan, K. Brendel, and R. J. Huxtable. "Pyrrolizidine Alkaloid-Induced Depletion of Taurine from Rat Liver In Vivo and In Vitro." In Advances in Experimental Medicine and Biology. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4899-0117-0_9.

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Liu, Dongyou. "Pyrrolizidine Alkaloids." In Handbook of Foodborne Diseases. CRC Press, 2018. http://dx.doi.org/10.1201/b22030-104.

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Conference papers on the topic "Pyrrolizidine alkaloid"

1

Schrenk, D. "Provisional relative potency factors for pyrrolizidine alkaloids – scientifically justified?" In Phytotherapiekongress 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1697263.

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Ober, Dietrich. "Repeated evolution of insect adaptations to toxic pyrrolizidine alkaloids of plants." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.94260.

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Rutz, L., L. Gao, and D. Schrenk. "Structure-dependent cytotoxicity of different pyrrolizidine alkaloids in primary rat hepatocytes." In Phytotherapiekongress 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1697293.

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Hadi, NSA, EE Bankoglu, O. Kelber, H. Sievers, and H. Stopper. "Studies on mechanism of genotoxicity of selected pyrrolizidine alkaloids in HepG2 cells in vitro." In Jubiläumskongress Phytotherapie 2021 Leib und Magen – Arzneipflanzen in der Gastroenterologie 50 Jahre Gesellschaft für Phytotherapie. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1731499.

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Haas, M., K. Wirachowski, JH Küpper, D. Schrenk, and J. Fahrer. "Structure-dependent genotoxicity and cytotoxicity of eleven pyrrolizidine alkaloids in CYP3A4-proficient human liver cells." In Jubiläumskongress Phytotherapie 2021 Leib und Magen – Arzneipflanzen in der Gastroenterologie 50 Jahre Gesellschaft für Phytotherapie. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1731472.

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Schenk, A., B. Siewert, S. Toff, and J. Drewe. "Determination of 34 pyrrolizidine alkaloids (PA) as contaminants in various plant extracts using UHPLC-ToF-HRMS." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608497.

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Forsch, K., B. Siewert, L. Disch, M. Unger, and J. Drewe. "In vitro screening of acute hepatic cytotoxicity of pyrrolizidine alkaloids in human and rodent hepatic cell lines." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608451.

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Reports on the topic "Pyrrolizidine alkaloid"

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Pereboom, D. P. K. H., M. de Nijs, J. G. J. Mol, and P. P. J. Mulder. Research study for pyrrolizidine alkaloids in alfalfa and herbal tea : EURLPT-MP02 (2019). Wageningen Food Safety Research, 2021. http://dx.doi.org/10.18174/545714.

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