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Dissertations / Theses on the topic 'Pyrrolizidine alkaloid'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Fortune, Grady Thomas Jr. "Structure-activity relationships in semisynthetic pyrrolizidine alkaloid antitumor agents." Diss., Georgia Institute of Technology, 1989. http://hdl.handle.net/1853/27371.

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2

Faulkner, Jerome Ralph. "INTERMEDIATE STEPS OF LOLINE ALKALOID BIOSYNTHESIS." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/209.

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Epichloë species and their anamorphs, Neotyphodium species, are fungal endophytes that inhabit cool-season grasses and often produce bioprotective alkaloids. These alkaloids include lolines, which are insecticidal and insect feeding deterrents. Lolines are exo-1-aminopyrrolizidines with an oxygen bridge between carbons 2 and 7, and are usually methylated and formylated or acetylated on the 1-amine. In previously published studies lolines were shown to be derived from the amino acids L-proline and L-homoserine. In addition the gene cluster involved in loline-alkaloid biosynthesis has also been

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3

Fleischmann, Thomas John. "Semisynthetic pyrrolizidine alkaloid antitumor agents and the toxic component of eupatorium rugosum." Diss., Georgia Institute of Technology, 1987. http://hdl.handle.net/1853/30343.

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4

Bhardwaj, Minakshi. "FORMATION OF THE ETHER BRIDGE IN THE LOLINE ALKALOID BIOSYNTHETIC PATHWAY." UKnowledge, 2017. http://uknowledge.uky.edu/chemistry_etds/75.

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Lolines are specialized metabolites produced by endophytic fungi, such as Neotyphodium and Epichloë species, that are in symbiotic relationships with cool-season grasses. Lolines are vital for the survival of the grasses because their insecticidal and antifeedant properties protect the plant from insect herbivory. Although lolines have various bioactivities, they do not have any concomitant antimammalian activities. Lolines have complex structures that are unique among naturally occurring pyrrolizidine alkaloids. Lolines have four contiguous stereocenters, and they contain an ether bridge conn

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5

Davis, Jonathan C. "Section one : photochemical methodologies towards the pyrrolizidine and indolizidine alkaloid skeleta; section two; synthesis of novel leukotriene photoaffinity labels." Thesis, University of Reading, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360717.

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6

Kruse, Lars Hendrik [Verfasser], Dietrich [Akademischer Betreuer] Ober, and Axel [Gutachter] Scheidig. "A multifaceted approach to identify unknown enzymes of pyrrolizidine alkaloid biosynthesis / Lars Hendrik Kruse ; Gutachter: Axel Scheidig ; Betreuer: Dietrich Ober." Kiel : Universitätsbibliothek Kiel, 2017. http://d-nb.info/1210925060/34.

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7

Kruse, Lars Hendrik Verfasser], Dietrich [Akademischer Betreuer] [Ober, and Axel [Gutachter] Scheidig. "A multifaceted approach to identify unknown enzymes of pyrrolizidine alkaloid biosynthesis / Lars Hendrik Kruse ; Gutachter: Axel Scheidig ; Betreuer: Dietrich Ober." Kiel : Universitätsbibliothek Kiel, 2017. http://nbn-resolving.de/urn:nbn:de:gbv:8-diss-211136.

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8

Dener, Jeffrey Mark. "Part I, the enantioselective synthesis of pyrrolizidine alkaloids using alpha-acylamino radical cyclizations ; Part II, the enantioselective synthesis of the indolizidine alkaloid (-)-swainsonine using an alpha-acylamino radical cyclization /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487591658176567.

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9

Vevers, William F. "Deoxynivalenol : toxicological profile and potential for reducing cereal grain contamination using bacterial additives in fermented animal feed." Thesis, University of Plymouth, 2015. http://hdl.handle.net/10026.1/4305.

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Deoxynivalenol (DON) contamination of grain destined for animal feeds is a major toxicological risk to monogastrics and is suspected of restricting productivity in ruminants. Whereas bacterial additives have been developed that can detoxify DON in the rumen and lower intestine, there are currently no commercial inoculants able to perform this task in crimped grain (CG) silage, a regionally important method of moist grain preservation based on homo- and heterofermentative lactic acid bacteria or chemical additives. Determining whether this ensiling process alongside the action of detoxifying ba

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10

Choi, Joong-Kwon. "Synthesis of pyrrolizidine alkaloids /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487259125219504.

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11

Pereira, Tamara Nishanthi. "Cytotoxic effects of pyrrolizidine alkaloids /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18303.pdf.

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12

Kim, Hea-Young. "Molecular Toxicology of Pyrrolizidine Alkaloids." DigitalCommons@USU, 1994. https://digitalcommons.usu.edu/etd/3910.

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Pyrrolizidine alkaloids are cytotoxic, carcinogenic, and anti-carcinogenic in vivo and in vitro, and they produce many hazardous effects in humans and animals. Pyrrolizidine alkaloids (PAs) also cross-link with DNA and/or protein. However, whether such cross-linking is important to the toxic action of PAs is not known. In addition, the exact mechanism underlying these DNA cross-links or cytotoxicity is also not clear. In three separate studies, I characterized the nature of PA-induced DNA cross-links and the relationships between PA structures and cross-linking potency. In the first study (Cha

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13

Tang, Minyan. "The asymmetric synthesis of polyhydroxylated pyrrolizidine alkaloids." Department of Chemistry - Faculty of Science, 2004. http://ro.uow.edu.au/theses/233.

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Chapter 1 of this thesis is a review of the literature on the structure, biological activities and synthesis of polyhydroxylated 3-hydroxymethylpyrrolizidine alkaloids. This Chapter also outlines he aims of this project, which were to develop a flexible synthesis of the 1,2,7-trihydroxy-3-hydroxymethylpyrroizidine alkaloid australine, and its epimers. Chapter 2 describes model synthetic chemical studies on the synthesis of the pyrrolizidine core structure. The key synthetic steps, the aminolysis reaction of vinyl expoxides with ally1 amine, the ring-closing metathesis of the resulting diene, s

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14

Cooper, Roland Arthur 1963. "Pyrrolizidine alkaloids: Chemical basis of toxicity." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/290581.

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In humans, livestock and experimental animals, pyrrolizidine alkaloids (PAs) are toxic as a consequence of their hepatic metabolism to reactive pyrrolic esters, or dehydroalkaloids (DHAs). Despite their similarity in structures, PAs often vary markedly in their lethality (LD₅₀s) and in the organs in which toxicity is expressed. We have examined whether there are differences in the physicochemical properties of certain DHAs which are associated with differences in patterns of metabolism and toxicity produced by the parent PA. Using a potentiometric method to measure hydrolysis, it was determine

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15

Wild, Stacie Lynn. "Pyrrolizidine alkaloids: Hepatic metabolism and extrahepatic toxicity." Diss., The University of Arizona, 1994. http://hdl.handle.net/10150/186599.

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Pyrrolizidine alkaloids are proposed to be metabolized in the liver to reactive pyrrole species, or dehydroalkaloids. These reactive pyrroles are hypothesized to be responsible for pyrrolizidine alkaloid toxicity. This dissertation research has established that dehydroalkaloids are, in fact, metabolites of pyrrolizidine alkaloids. It was first determined that dehydromonocrotaline is produced during hepatic microsomal metabolism of monocrotaline and that it has the ability to bind in vitro with a synthetic thiol-containing resin, Thiopropyl Sepharose 6B. Similarly, synthetic dehydromonocrotalin

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16

Mitchell, Douglas. "Synthetic studies towards pyrrolizidine and indolizidine alkaloids." Thesis, Sheffield Hallam University, 1992. http://shura.shu.ac.uk/20067/.

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This project was concerned with the synthesis of the pyrrolizidine alkaloids supinidine, trachelanthamidine and isoretronecanol and also synthetic studies towards the indolizidine alkaloid 251D. In all cases, the synthesis began from a cheap, readily-available, simple amino acid, in this case glutamic acid, and proceeded to a suitable monocyclic intermediate which could then undergo an intramolecular Horner-Wittig cyclisation reaction to form the required bicyclic core structure. Subsequent modification reactions then led in the pyrrolizidine series to penultimate precursors of the target alka

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17

Drew, Gail L. "DNA-Protein Cross-Linking by Pyrrolizidine Alkaloids." DigitalCommons@USU, 1997. https://digitalcommons.usu.edu/etd/3919.

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Pyrrolizidine alkaloids (PAs) are natural plant compounds found in hundreds of plant species worldwide and are reported to have cytotoxic, carcinogenic, antimitotic, and gentotoxic activity. PAs are metabolized by the cytochrome P450 (CYP) sytem to the pyrrole or the N-oxide form. They pyrroles are bifunctional electrophillic alkylators that bind cellular nucleophiles such as DNA and proteins and disrupt normal cell processes, including DNA replication and gene transcription, and can cause megalocytosis. The pyrroles dehyrosenecionine (DHSN) and dehydromoncrotaline (DHMO) are among the most po

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18

Affolter, Olena. "Alkaloide aus Alkaloiden enzymatische Funktionalisierung von Tropenonen und deren Anwendung in der Synthese von Pyrrolizidinen." Berlin mbv, 2008. http://d-nb.info/993371027/04.

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19

Bezerra, Denise Aline Casimiro. "Contribuição ao estudo químico de plantas tóxicas do Semiárido: Crotalaria vitelina Ker Gawl e Ipomoea philomega (Vell.) House." Universidade Federal da Paraíba, 2013. http://tede.biblioteca.ufpb.br:8080/handle/tede/6791.

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Made available in DSpace on 2015-05-14T12:59:54Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 7265191 bytes, checksum: 432cedb6fda0226806b02fd0634dfff5 (MD5) Previous issue date: 2013-08-12<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>The poisonous plants to livestock research has been restricted only the identification of poison species, epidemiology and clinical signs. But the active principle of toxic plants are little known and its knowledge its very important to develop preventive methods to poisoning which are responsible by countless cattle deaths. T

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20

Hagan, Desmond Bernard. "Biosynthesis and synthesis of pyrrolizidine alkaloids and analogues." Thesis, University of Glasgow, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284533.

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21

Ryan, Edward Thomas. "The determination of the partition coefficients for a variety of pyrrolizidine alkaloids and the relationship of these values to the anti-tumor activity of the alkaloids." Thesis, Georgia Institute of Technology, 1988. http://hdl.handle.net/1853/27574.

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22

Pink, Jennifer Helen. "Synthesis of fused lactams via N-acyliminium ions." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242373.

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23

Chisholm, Grieg. "Synthesis and biological activity of Pyrrolizidine alkaloids and analogues." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296045.

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24

Matheson, Jane Reid. "Biosynthesis of pyrrolizidine alkaloids and bio-transformations of diamines." Thesis, University of Glasgow, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284519.

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25

Logie, Catherine Gwynedd. "The pyrrolizidine alkaloids of Senecio chrysocoma and Senecio paniculatus." Thesis, Rhodes University, 1996. http://hdl.handle.net/10962/d1005000.

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In order to compare the pyrrolizidine alkaloid content of two closely related species, Senecio chrysocoma and S. paniculatus, nine populations of plants distributed between the two species, were examined. Three novel pyrrolizidine alkaloids, 7ß-angelyl-l-methylene-8∝-pyrrolizidine, 7ß-angelyl-l-methylene-8∝-pyrrolizidine and 7ß-angelyl-l-methyleneSO!-pyrrolizidine-4-oxide, as well as eight known pyrrolizidine alkaloids, 7-angelylhastanecine, 9-angelylhastanecine, 7-angelylplatynecine, 9-angelylplatynecine, 9-angelylplatynecine-4-oxide, sarracine, neosarracine and retrorsine, were isolated and

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26

Rosemann, G. M. (Gertruida Magdalena). "Analysis of pyrrolizidine alkaloids in Crotalaria species by HPLC-MS/MS in order to evaluate related food health risks." Thesis, University of Pretoria, 2007. http://hdl.handle.net/2263/26960.

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Pyrrolizidine alkaloids (PAs) are one of the most significant groups of plant toxins in the world and are an important cause of poisoning in livestock, resulting in significant financial and production losses each year (Kellerman et al. 1996). Pyrrolizidine alkaloids may also enter the human food chain as contaminants of grains, via animal products such as milk, eggs and honey or may be consumed as constituents of herbal medicines (ANZFA 2001). Not all PAs are toxic. Pyrrolizidine alkaloids affecting human health are the esters of 1,2-unsaturated hydroxymethyl dehydropyrrolizidines (DHP). Befo

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27

Huizing, Hindrik J. "Phytochemistry, systematics and biogenesis of pyrrolizidine alkaloids of Symphytum taxa /." [S.l. : s.n.], 1985. http://www.gbv.de/dms/bs/toc/011519487.pdf.

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28

Asibal, Clarita Florendo. "Isolation and structural elucidation of pyrrolizidine alkaloids from four plant sources." Diss., Georgia Institute of Technology, 1987. http://hdl.handle.net/1853/30246.

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29

Abd, Elhady Mohamed Ibrahim Saleh Mohamed. "Transgenic plants as tool to study the evolution of pyrrolizidine alkaloids." [S.l.] : [s.n.], 2006. http://www.digibib.tu-bs.de/?docid=00009619.

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30

Bonetti, Sandra J. "Studies on the isolation and biotransformation of pyrrolizidine alkaloids and related bioactive compounds." Diss., Georgia Institute of Technology, 1988. http://hdl.handle.net/1853/30244.

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31

Grue, Margaret Ruth. "A study of the alkaloid content of the Senecio speciosus/Macrocephalus complex." Thesis, Rhodes University, 1992. http://hdl.handle.net/10962/d1005027.

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The isolation and identification of pyrrolizidine alkaloids from various plant species from 1988 to May 1991 are reviewed and the alkaloids of two indigenous plant species, Senecio speciosus Willd and Senecio macrocephalus DC, were investigated. A brief review of the methods used for isolation and identification of pyrrolizidines is also given. S. speciosus was found to contain two new alkaloids, 7-senecioyl-9-sarracinylheliotridine and 7-isosarracinyl-9- sarracinyl-heliotridine, which were identified using highfield NMR techniques. A number of other alkaloids were tentatively identified using

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32

Nuntawong, Nuchnipa. "Comparative study of pyrrolizidine alkaloids in Heliotropium indicum, H. amplexicaule and H. arborescens." Thesis, Liverpool John Moores University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343131.

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33

Frazier, James Owen. "Intramolecular [4+1] pyrroline annulation as a general method for the synthesis of pyrrolizidine alkaloids." Thesis, Virginia Polytechnic Institute and State University, 1986. http://hdl.handle.net/10919/91092.

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A general methodology for the synthesis of pyrrolizidine alkaloids has been developed. The two key steps in the sequence were the synthesis of the dienic azide system 1 and its regioisomer 2 by utilizing the vinylogous Reformatsky reaction, and the intramolecular additions of the azide moiety across the activated dienes with subsequent pyrolyses to provide the pyrrolizidines of type 3. This study broadened the scope of the vinylogous Reformatsky reaction to include the preparation of alkaloid synthons and introduced the heteroatom equivalent of the carbenoid [4+1] annulation as a method or alk

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34

Yang, Yicheng. "Quantitative analysis and reaction of pyrrolizidine alkaloids and its metabolites by nuclear magnetic resonance spectroscopy." Thesis, London Metropolitan University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542799.

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35

Langel, Dorothee. "Biosynthesis of the unique necic acid moiety in lycopsamine type pyrrolizidine alkaloids a molecular approach." Göttingen Cuvillier, 2008. http://d-nb.info/989861198/04.

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36

Brock, Elizabeth Anne. "Alkaloids from transannular iodoaminations." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:0feddc99-0fde-4dcd-b717-b0c6b0515615.

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This thesis is concerned with the development of transannular iodoamination methodology for the synthesis of pyrrolizidine, indolizidine and tropane alkaloids. Chapter 1 introduces the concept of a ‘transannular cyclisation’ and outlines the utility of such cyclisations in the synthesis of a range of [x.y.z]-azabicyclic alkaloids. Chapter 2 describes the development of a three step lithium amide conjugate addition, ring-closing metathesis and transannular iodoamination protocol for the preparation of the pyrrolizidine scaffold ([3.3.0]-azabicycle). Cyclisation of a hexahydroazocine occurs with

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37

Wang, Linzhu [Verfasser]. "Molekulare Identifizierung und Charakterisierung der Flavin-abhängigen Monooxygenasen in verschiedenen Pyrrolizidin-Alkaloid-adaptierten Insekten / Linzhu Wang." Kiel : Universitätsbibliothek Kiel, 2013. http://d-nb.info/1031190201/34.

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38

Weber, Susanne. "Untersuchungen zur Biosynthese der Pyrrolizidin-Alkaloide vom Lycopsamin-Typ an Wurzelkulturen von Eupatorium clematideum /." Göttingen : Cuvillier, 1998. http://www.gbv.de/dms/bs/toc/241852374.pdf.

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39

Dimande, Alberto Francisco Paulo. "The toxicity of Senecio inaequidens DC." Diss., Electronic thesis, 2007. http://upetd.up.ac.za/thesis/available/etd-05122008-080613/.

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40

Wesseling, Anne-Maria [Verfasser], Dietrich [Akademischer Betreuer] Ober, and Eva [Gutachter] Stukenbrock. "Pyrrolizidine alkaloids and homospermidine synthases in grasses (Poaceae) / Anne-Maria Wesseling ; Gutachter: Eva Stukenbrock ; Betreuer: Dietrich Ober." Kiel : Universitätsbibliothek Kiel, 2017. http://d-nb.info/1236287487/34.

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41

Letsyo, Emmanuel [Verfasser]. "Quantification and Profiling of Pyrrolizidine Alkaloids in Honey, Herbal Medicines and the Tissues of Lappula squarrosa / Emmanuel Letsyo." Göttingen : Cuvillier Verlag, 2017. http://d-nb.info/1143145852/34.

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42

Rösemann, G. M. "Analysis of pyrrolizidine alkaloids in Crotalaria species by HPLC-MS/MS in order to evaluate related food health risks." Electronic thesis, 2006. http://upetd.up.ac.za/thesis/available/etd-08032007-170633/.

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43

Conegero, Leila de Souza. "Estudos visando a sintese de alcaloides pirrolizidinicos e indolizidinicos : aproveitamento da (+)-retronecina e do acido D-isoascorbico." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249280.

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Orientador: Ronaldo Aloise Pilli<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-08-08T05:17:50Z (GMT). No. of bitstreams: 1 Conegero_LeiladeSouza_D.pdf: 3438551 bytes, checksum: 26a173748a7748d7ec479a812badeeb7 (MD5) Previous issue date: 2006<br>Resumo: O trabalho desenvolvido visou a obtenção de alcalóides pirrolizidínicos e indolizidínicos utilizando a (+)-retronecina (1) e o ácido D-isoascórbico (35D) como matérias primas, respectivamente. A retronecina (1) foi isolada da espécie vegetal Senecio brasiliensis. Para a prepar

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44

Becerra, Jimenez Jaime [Verfasser]. "Phytochemical and analytical studies of feed and medicinal plants in relation to the presence of toxic pyrrolizidine alkaloids / Jaime Becerra Jimenez." Bonn : Universitäts- und Landesbibliothek Bonn, 2013. http://d-nb.info/1045276669/34.

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Sandini, Thaísa Meira. "Estudos comportamentais e bioquímicos da exposição perinatal ao Senecio brasiliensis na prole de ratos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-25022013-143518/.

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Senecio brasiliensis, conhecida popularmente como maria-mole, é uma das principais causas de intoxicação em animais de produção, principalmente em eqüinos e bovinos. A toxicidade desta planta ocorre devido à presença dos alcalóides pirrolizidínicos (APs), os quais sofrem biotransformação no fígado gerando como metabólitos tóxicos os pirróis. Além disso, esses compostos tóxicos podem ser transferridos para o homem através de produtos comestíveis de origem animal contaminados ou pelo uso na medicina popular. Até o momento, não há relatos a respeito de seus efeitos tóxicos sobre a prole de animai

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46

Carvalho, José Carlos Borges de. "Estudo químico e biológico das espécies vegetais caboverdianas Echium hypertropicum Webb e Echium stenosiphon Webb subsp. Stenosiphon." Niterói, 2017. https://app.uff.br/riuff/handle/1/3281.

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Submitted by Biblioteca da Faculdade de Farmácia (bff@ndc.uff.br) on 2017-04-04T17:26:03Z No. of bitstreams: 1 Carvalho, José Carlos Borges de [Dissertação, 2013].pdf: 4019706 bytes, checksum: 84b0655827cda5d4ea9ce98d03f1736c (MD5)<br>Made available in DSpace on 2017-04-04T17:26:03Z (GMT). No. of bitstreams: 1 Carvalho, José Carlos Borges de [Dissertação, 2013].pdf: 4019706 bytes, checksum: 84b0655827cda5d4ea9ce98d03f1736c (MD5)<br>Echium hypertropicum Webb e Echium stenosiphon Webb subsp. stenosiphon são arbustos endêmicos de Cabo Verde, usados na medicina popular para o tratamento de dis

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47

Rossi, Fanny. "Vers une valorisation industrielle d’un remède traditionnel pour le traitement des intoxications ciguatériques." Thesis, Polynésie française, 2014. http://www.theses.fr/2014POLF0002/document.

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Malgré leur existence ancienne et leur incidence dans la zone intertropicale, aucun traitement efficace, autre que symptomatique, n’est disponible à l’heure actuelle pour traiter les intoxications ciguatériques. La médecine traditionnelle à base de plantes vient alors au secours des populations. Dans la région du Pacifique, une des plantes les plus utilisées, et présentant des potentialités dans le traitement de la ciguatéra, est Heliotropium foertherianum Diane & Hilger. Toutefois, cette plante, de la famille des Borraginacées, est connue pour produire des alcaloïdes pyrrolizidiniques, co

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48

Kaltner, Florian [Verfasser], Michael [Akademischer Betreuer] Rychlik, Karl-Heinz [Gutachter] Engel, and Michael [Gutachter] Rychlik. "Investigations on Behaviour, Occurrence and Risk Assessment of Toxic Pyrrolizidine Alkaloids in Various Food and Feed Matrices / Florian Kaltner ; Gutachter: Karl-Heinz Engel, Michael Rychlik ; Betreuer: Michael Rychlik." München : Universitätsbibliothek der TU München, 2020. http://d-nb.info/1213447704/34.

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49

Elias, Fabiana. "Avaliação imunotóxica e de imunoteratologia de Senecio brasiliensis: estudo em ratos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-26092012-111803/.

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O presente estudo visou avaliar os possiveis efeitos imunotóxicos e imunoteratogênicos da integerrimina N-óxido presente no resíduo butanólico (RB) do ,Senecio brasiliensis, uma planta hepatotóxica que contém alcalóides pirrolizidínicos (APs). Tem sido relatado o uso de APs como fitoterápicos em todo o mundo e também como contaminantes de pastagens e alimentos, sendo assim responsáveis por intoxicações em animais de produção e humanos; porém, até o momento, não há relatos de sua ação sobre o sistema imune. Assim, após a extração da planta, quantificou-se no RB de Senecio brasiliensis, por meio

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Parizotto, Leíse Herrmann. "Intoxicação experimental por senecio oleosus em frangos de corte." Universidade do Estado de Santa Catarina, 2015. http://tede.udesc.br/handle/handle/931.

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Abstract:

Made available in DSpace on 2016-12-08T16:24:20Z (GMT). No. of bitstreams: 1 PGCA15MA166.pdf: 955554 bytes, checksum: a7513a7a99db2af80031aee98a3385bf (MD5) Previous issue date: 2015-02-20<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Senecio oleosus is a plant of Astereacea family found in the South and Southeast of Brazil. Species of this genus are recognized to produce liver damage in different animal species, including in human. This study aimed to evaluate the toxicity of S. oleosus in poultry (Gallus gallus domesticus). Green leaves of S. oleosus were collected in

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