Relevant bibliographies by topics / Pyrrolizidines

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Pyrrolizidines'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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Journal articles on the topic "Pyrrolizidines"

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Jurczak, Janusz, Marcin Lindner, and Antoni Krasiński. "Facile, Stereocontrolled Synthetic Route towards Bis-functionalised Pyrrolizidines." Synthesis 50, no. 21 (2018): 4295–300. http://dx.doi.org/10.1055/s-0037-1609582.

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A simple and convenient method for the synthesis of bis-functionalised pyrrolizidines starting from readily available N-Cbz-l-prolinal is described. This aldehyde was converted within two concise steps to the corresponding aminoepoxides, which were separately subjected to regioselective cyclisation induced by a reductive cleavage of the Cbz protecting group. The versatile and concise strategy holds great potential for practical application in the straightforward preparation of pyrrolizidine-based drugs and natural products.
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Reddy, Marri Sameer, Nandigama Satish Kumar, and L. Raju Chowhan. "Heterogeneous graphene oxide as recyclable catalyst for azomethine ylide mediated 1,3 dipolar cycloaddition reaction in aqueous medium." RSC Advances 8, no. 62 (2018): 35587–93. http://dx.doi.org/10.1039/c8ra06714g.

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Graphene oxide (GO) catalyzed regio and diastereoselective synthesis of spiro-indenoquinoxaline pyrrolizidines and spiro-oxindoles pyrrolizidines is described with good substrate scope and yield using azomethine ylide under aq. EtOH condition at RT.
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Nájera, Carmen, and José Miguel Sansano. "Synthesis of pyrrolizidines and indolizidines by multicomponent 1,3-dipolar cycloaddition of azomethine ylides." Pure and Applied Chemistry 91, no. 4 (2019): 575–96. http://dx.doi.org/10.1515/pac-2018-0710.

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Abstract Different multicomponent 1,3-dipolar cycloadditions (1,3-DC) of cyclic α-amino acid derivatives with aldehydes and dipolarophiles have been described as efficient and simple methodologies for the synthesis of the pyrrolidine unit of pyrrolizidines and indolizidines. When free cyclic α-amino acids are used, a thermal promoted decarboxylative process generates in situ the corresponding non-stabilized azomethine ylides, which afforded the corresponding pyrrolizidines and indolizidines with a hydrogen in the bicyclic units. This methodology has been employed to the synthesis of complex sy
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Egorov, Victor A., Lidiya S. Khasanova, Fanuza A. Gimalova, Alexander N. Lobov, and Mansur S. Miftakhov. "Straightforward synthesis of pyrrolizidines." Mendeleev Communications 27, no. 2 (2017): 163–65. http://dx.doi.org/10.1016/j.mencom.2017.03.019.

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Massicot, Fabien, Gatien Messire, Alexis Vallée, Jean-Luc Vasse, Sandrine Py, and Jean-Bernard Behr. "Regiospecific formation of sugar-derived ketonitrone towards unconventional C-branched pyrrolizidines and indolizidines." Organic & Biomolecular Chemistry 17, no. 29 (2019): 7066–77. http://dx.doi.org/10.1039/c9ob01419e.

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Coelho, Fernando, Kristerson de Luna Freire, and Cláudio Tormena. "Heck Reaction on Morita-Baylis-Hillman Adducts: Diastereoselective Synthesis of Pyrrolizidinones and Pyrrolizidines." Synlett 2011, no. 14 (2011): 2059–63. http://dx.doi.org/10.1055/s-0030-1261161.

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Klipkov, Anton, Igor Gerus, and Alexander Sorochinsky. "Synthesis of fluorinated pyrrolizidine, indolizidine and quinolizidine derivatives." Ukr. Bioorg. Acta 2022, Vol. 17, N1 17, no. 1 (2022): 22–39. http://dx.doi.org/10.15407/bioorganica2022.01.022.

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This review provides literature data dealing with the synthesis of fluorinated pyrrolizidines, indolizidines, and quinolizidines. Synthesis of trifluoromethylated derivatives requires to use of commercially available building blocks bearing pre-installed trifluoromethyl group or synthetic trifluoromethylated templates incorporating a chiral auxiliary as starting materials. On the other hand, nucleophilic or radical difluoromethylation followed by cyclization reactions using different types of stable and readily available difluoromethylating agents was established as an efficient approach for t
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Samala, Srinivas, Do Hyun Ryu, Choong Eui Song, and Eun Jeong Yoo. "Multicomponent dipolar cycloadditions: efficient synthesis of polycyclic fused pyrrolizidinesviaazomethine ylides." Organic & Biomolecular Chemistry 17, no. 7 (2019): 1773–77. http://dx.doi.org/10.1039/c8ob02463d.

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Biswas, Rayhan G., and Vinod K. Singh. "Direct enantioselective synthesis of pyrrolizidines." Tetrahedron Letters 69 (April 2021): 152954. http://dx.doi.org/10.1016/j.tetlet.2021.152954.

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Shahrestani, Naeimeh, Hormoz Khosravi, Khosrow Jadidi, Behrouz Notash, and Soheila Naderi. "Organocatalytic synthesis of enantiopure spiro acenaphthyl-pyrrolizidine/pyrrolidines: justifying the regioselectivity based on a distortion/interaction model." Organic & Biomolecular Chemistry 17, no. 29 (2019): 7013–24. http://dx.doi.org/10.1039/c9ob01197h.

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An efficient organocatalytic synthesis of chiral spiroacenaphthyl-pyrrolidines/pyrrolizidines with high regio- and diastereoselectivity (up to 99%) with exact specification of the absolute configuration is described for the first time.
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Dissertations / Theses on the topic "Pyrrolizidines"

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Joãoa, Heidi. "Synthesis of pyrrolobenzothiadiazepines, pyrrolizidines and indoles." Thesis, University of Huddersfield, 2014. http://eprints.hud.ac.uk/id/eprint/23691/.

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In this thesis, novel syntheses of analogues of pyrrolobenzodiazepines (PBDs) are described. These compounds are of great interest as synthetic targets due to their potential medical properties. The first process involved is the intramolecular 1,3‐dipolar cycloaddition between the azide and imine present to form the PBD core, a process that occurs via cycloaddition and extrusion of nitrogen. An azide to nitrile cycloaddition was also explored. As an extension to azide work, a series of 2‐azidobenzenesulfonamides with homoallylic substituents were investigated as precursors in aza‐Prins reactio
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Freire, Kristerson Reinaldo de Luna. "Síntese assimétrica de pirrolizidinonas e pirrolizidinas substituídas a partir da reação de Morita-Baylis-Hillman." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250256.

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Orientador: Fernando Antônio Santos Coelho<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-18T09:19:04Z (GMT). No. of bitstreams: 1 Freire_KristersonReinaldodeLuna_D.pdf: 11850497 bytes, checksum: e314153107dd07d9368b43666918d973 (MD5) Previous issue date: 2011<br>Resumo: As glicosidases regulam uma grande variedade de processos biológicos, incluindo a catálise, degradação, e biossíntese de oligossacarídeos e glicoconjugados. Inibidores eficientes dessas enzimas podem ser aplicados para o tratamento de várias doenças ou dis
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Tyrrell, Andrew J. "Approaches to the synthesis of bioactive pyrrolizidines." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497131.

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Choi, Joong-Kwon. "Synthesis of pyrrolizidine alkaloids /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487259125219504.

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Ryan, Edward Thomas. "The determination of the partition coefficients for a variety of pyrrolizidine alkaloids and the relationship of these values to the anti-tumor activity of the alkaloids." Thesis, Georgia Institute of Technology, 1988. http://hdl.handle.net/1853/27574.

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Bonetti, Sandra J. "Studies on the isolation and biotransformation of pyrrolizidine alkaloids and related bioactive compounds." Diss., Georgia Institute of Technology, 1988. http://hdl.handle.net/1853/30244.

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Despinoy, Xavier Luc Marie. "A pyrrolizin-3-one route to naturally occurring pyrrolizidines." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/14764.

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The initial aim of this thesis was to apply and extend the chemistry of pyrrolizin-3-one ring systems to the synthesis of naturally occurring pyrrolizidine alkaloids. The methods of synthesis of unsubstituted-, 1-monosubstituted-, 7-monosubstituted- and 1,7-disubstituted pyrrolizidin-3-ones have been reviewed. Many pyrrolizin-3-ones have been synthesised by Flash Vacuum Pyrolysis (FVP) of propenoate ester derivatives or Meldrum's acid derivatives. A new synthetic route to pyrrolizin-3-ones substituted at the 1-position by electron-withdrawing groups has been developed by FVP of Wittig condensa
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Fortune, Grady Thomas Jr. "Structure-activity relationships in semisynthetic pyrrolizidine alkaloid antitumor agents." Diss., Georgia Institute of Technology, 1989. http://hdl.handle.net/1853/27371.

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Asibal, Clarita Florendo. "Isolation and structural elucidation of pyrrolizidine alkaloids from four plant sources." Diss., Georgia Institute of Technology, 1987. http://hdl.handle.net/1853/30246.

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Sibley, A. William. "Slaframine, australines and castanospermines." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363593.

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Books on the topic "Pyrrolizidines"

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International Program on Chemical Safety, International Labour Organisation, and United Nations Environment Programme, eds. Pyrrolizidine alkaloids health and safety guide. World Health Organization, 1989.

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M, Rizk A., ed. Naturally occurring pyrrolizidine alkaloids. CRC Press, 1991.

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Máčel, Mirka. On the evolution of the diversity of pyrrolizidine alkaloids: The role of insects as selective forces. Universiteit Leiden, 2003.

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Hol, Wilhelmina Hermina Geertruida. The role of pyrrolizidine alkaloids from Senecio jacobaea in the defence against fungi. Universiteit Leiden, 2003.

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Otten, Martina Gisela. Enantioselektive Synthese von Pyrrolizidin-Derivaten. [s.n.], 1994.

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Huizing, Hindrik Jan. Phytochemistry, systematics and biogenesis of pyrrolizidine alkaloids of Symphytum taxa. Krips Repro, 1985.

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Janowitz, Agnes Klara Gretel. Aufbau von Pyrrolizidin-, Indolizidin- und Chinolizidin-Ringgerüsten: Synthese von Xenovenin. Zentralstelle der Studentenschaft, 1994.

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Mauz, Joachim Christoph. Vorkommen und Genotoxizität von Pyrrolizidin-Alkaloiden in Petasites hybridus L. und die Entfernung der Alkaloide aus Arzneipflanzenextrakten. [s.n.], 1987.

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Chemistry and toxicology of pyrrolizidine alkaloids. Academic Press, 1986.

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World Health Organization (WHO). Pyrrolizidine Alkaloids. World Health Organization, 1988.

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Book chapters on the topic "Pyrrolizidines"

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Mroczek, T., and K. Glowniak. "Pyrrolizidine Alkaloids." In Natural Products in the New Millennium: Prospects and Industrial Application. Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-015-9876-7_1.

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Liu, Dongyou. "Pyrrolizidine Alkaloids." In Handbook of Foodborne Diseases. CRC Press, 2018. http://dx.doi.org/10.1201/b22030-104.

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Lukefahr, Steven D., James I. McNitt, Peter R. Cheeke, and Nephi M. Patton. "Toxins in feeds." In Rabbit production, 10th ed. CABI, 2022. http://dx.doi.org/10.1079/9781789249811.0009.

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Abstract This chapter describes the sources, composition, mode of action, clinical signs, diagnosis and treatment of poisoning in rabbits due to different types of toxins, including goitrogens, gossypol, lectins, mimosine, mycotoxins, nitrates, oxalates, pyrrolizidine alkaloids, saponins, trypsin inhibitors, urea, poisonous plants, pesticides and herbicides.
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Westendorf, J. "Pyrrolizidine Alkaloids — General Discussion." In Adverse Effects of Herbal Drugs. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-49340-9_16.

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Westendorf, J. "Pyrrolizidine Alkaloids — Cynoglossum officinale." In Adverse Effects of Herbal Drugs. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-49340-9_17.

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Westendorf, J. "Pyrrolizidine Alkaloids — Petasites Species." In Adverse Effects of Herbal Drugs. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-49340-9_18.

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Westendorf, J. "Pyrrolizidine Alkaloids — Senecio Species." In Adverse Effects of Herbal Drugs. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-49340-9_19.

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Westendorf, J. "Pyrrolizidine Alkaloids — Symphytum Species." In Adverse Effects of Herbal Drugs. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-49340-9_20.

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Westendorf, J. "Pyrrolizidine Alkaloids — Tussilago farfara." In Adverse Effects of Herbal Drugs. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-49340-9_21.

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Segall, H. J., D. W. Wilson, M. W. Lamé, D. Morin, and C. K. Winter. "Metabolism of Pyrrolizidine Alkaloids." In Handbook of Natural Toxins. CRC Press, 2024. https://doi.org/10.1201/9781003573760-3.

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Conference papers on the topic "Pyrrolizidines"

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Scaramal, João P. S., Kristerson R. Luna-Freire, and and Fernando Coelho. "Substrate-controlled Asymmetric Morita-Baylis-Hillman Reaction: an Approach to the Synthesis of Pyrrolizidinones and Pyrrolizidines." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_20131014152540.

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Goti, Andrea, Valentina Fedi, and Alberto Brandi. "A Straightforward Route to Enantiopure Pyrrolizidines by Cycloaddition to Pyrroline N-Oxides Derived from the Chiral Pool." In The 1st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1997. http://dx.doi.org/10.3390/ecsoc-1-02011.

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Santos, Airam O., José Tiago Menezes Correia, and Silvio Cunha. "Synthesis of pyrrolizidines, indolizidines and pyrroloazepines through formal aza-[3+3] and aza-[3+2] cycloadditions of enaminones with maleic anhydride and maleimides." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0315-1.

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Schrenk, D. "Provisional relative potency factors for pyrrolizidine alkaloids – scientifically justified?" In Phytotherapiekongress 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1697263.

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Krause, Julius, Nanina Tron, Georg Maier, et al. "Detection of pyrrolizidine alkaloid containing herbs using hyperspectral imaging in the short-wave infrared." In OCM 2021 - 5th International Conference on Optical Characterization of Materials. KIT Scientific Publishing, 2021. http://dx.doi.org/10.58895/ksp/1000128686-5.

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Plants containing pyrrolizidine alkaloids (PA) are unwanted contaminants in consumer products such as herbal tea due to their toxicity to humans. The detection of these plants or their components using hyperspectral imaging was investigated, with focus on application in sensor-based sorting. For this, 431 hyperspectral images of leafs from three common herbs (peppermint, lemon balm, stinging nettle) and the poisonous common groundsel were acquired. By using a convolutional neural network, a mean F1 score of 0.89 was obtained for the classification of all four plant products based on the indivi
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Ober, Dietrich. "Repeated evolution of insect adaptations to toxic pyrrolizidine alkaloids of plants." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.94260.

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Song, Zijing, Yisheng He, and Ge Lin. "Pyrrolizidine alkaloids induced obstructive pulmonary disease more than pulmonary vascular diseases." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.539980.

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Pan, Yueyang, Jiang MA, and Ge Lin. "Investigation of hepatotoxicity of structurally diverse pyrrolizidine alkaloids in zebrafish model." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.536800.

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Rutz, L., L. Gao, and D. Schrenk. "Structure-dependent cytotoxicity of different pyrrolizidine alkaloids in primary rat hepatocytes." In Phytotherapiekongress 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1697293.

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Hadi, NS A., E. E. Bankoglu, O. Kelber, H. Sievers, and H. Stopper. "Studies on mechanism of genotoxicity of selected pyrrolizidine alkaloids in HepG2 cells." In GA – 69th Annual Meeting 2021, Virtual conference. Georg Thieme Verlag, 2021. http://dx.doi.org/10.1055/s-0041-1736986.

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Reports on the topic "Pyrrolizidines"

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Pereboom, D. P. K. H., I. Elbers, M. de Nijs, and P. P. J. Mulder. Proficiency test for pyrrolizidine alkaloidsin food matrices : EURLPT-MP07 (2022). Wageningen Food Safety Research, 2023. http://dx.doi.org/10.18174/585165.

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Pereboom, D. P. K. H., M. de Nijs, J. G. J. Mol, and P. P. J. Mulder. Research study for pyrrolizidine alkaloids in alfalfa and herbal tea : EURLPT-MP02 (2019). Wageningen Food Safety Research, 2021. http://dx.doi.org/10.18174/545714.

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