Relevant bibliographies by topics / Pyrrolo[3,2-d]pyrimidine

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Pyrrolo[3,2-d]pyrimidine'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Pyrrolo[3,2-d]pyrimidine"

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Cawrse, Brian M., Nia’mani M. Robinson, Nina C. Lee, Gerald M. Wilson, and Katherine L. Seley-Radtke. "Structural and Biological Investigations for a Series of N-5 Substituted Pyrrolo[3,2-d]pyrimidines as Potential Anti-Cancer Therapeutics." Molecules 24, no. 14 (2019): 2656. http://dx.doi.org/10.3390/molecules24142656.

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Pyrrolo[3,2-d]pyrimidines have been studied for many years as potential lead compounds for the development of antiproliferative agents. Much of the focus has been on modifications to the pyrimidine ring, with enzymatic recognition often modulated by C2 and C4 substituents. In contrast, this work focuses on the N5 of the pyrrole ring by means of a series of novel N5-substituted pyrrolo[3,2-d]pyrimidines. The compounds were screened against the NCI-60 Human Tumor Cell Line panel, and the results were analyzed using the COMPARE algorithm to elucidate potential mechanisms of action. COMPARE analys
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Javahershenas, Ramin, and Jabbar Khalafy. "A new synthesis of pyrrolo[3,2-d]pyrimidine derivatives by a one-pot, three-component reaction in the presence of L-proline as an organocatalyst." Heterocyclic Communications 24, no. 1 (2018): 37–41. http://dx.doi.org/10.1515/hc-2017-0187.

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Abstract A one-pot, three-component reaction of 4-hydroxycoumarin, arylglyoxals, and 6-aminouracil or 1,3-dimethyl-6-aminouracil in the presence of L-proline as an organocatalyst in acetic acid under reflux conditions provided a series of new pyrrolo[3,2-d]pyrimidine derivatives in good yields.
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He, Ping, Jing Wu, Yang-Gen Hu, et al. "Efficient and Selective Construction of Pyrrolo[3,2-d]pyrimidine Derivatives." Bulletin of the Korean Chemical Society 35, no. 2 (2014): 617–21. http://dx.doi.org/10.5012/bkcs.2014.35.2.617.

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He, Ping, Jing Wu, Yang-Gen Hu, et al. "ChemInform Abstract: Efficient and Selective Construction of Pyrrolo[3,2-d]pyrimidine Derivatives." ChemInform 45, no. 37 (2014): no. http://dx.doi.org/10.1002/chin.201437180.

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Zeng, Qing, Demin Ren, Xingliang Fu, and Xiaofang Li. "Synthesis of Spiro[Pyrrolo[2,1-b][1,3]Benzothiazole-3,2′-[1,3]Thiazolo[3,2-a] Pyrimidine] via Cycloaddition Reactions." Journal of Chemical Research 42, no. 5 (2018): 260–63. http://dx.doi.org/10.3184/174751918x15260567362969.

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The 1,3-dipolar cycloaddition reaction of ethyl-5-aryl-2-[( Z)-2-methoxy-2-oxoethylidene]-7-methyl-3-oxo-3,5-dihydro-2 H-thiazolo[3,2- a] pyrimidine-6-carboxylates and azomethine ylide, which was generated in situ by the reaction of N-4-methoxyphenacylbenzothiazolium bromides and triethylamine, yielded novel 6′-ethyl-2-methyl-5′-aryl-1-(4-methoxybenzoyl)-7-methyl-3′-oxo-1,2-dihydro-5 H-spiro[pyrrolo[2,1- b][1,3]benzothiazole-3,2′-[1,3]thiazolo[3,2- a]pyrimidine]-2,6′-dicarboxylates in moderate yields. The structures of all of the products were characterised by NMR, IR, HRMS spectrometry, toget
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Taylor, Edward C., and Wendy B. Young. "Pyrrolo[3,2-d]pyrimidine Folate Analogs: "Inverted" Analogs of the Cytotoxic Agent LY231514." Journal of Organic Chemistry 60, no. 24 (1995): 7947–52. http://dx.doi.org/10.1021/jo00129a040.

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Cupps, Thomas L., Dean S. Wise, and Leroy B. Townsend. "A novel three-step synthesis of a pyrrolo[3,2-d]pyrimidine C-nucleoside." Journal of Organic Chemistry 51, no. 7 (1986): 1058–64. http://dx.doi.org/10.1021/jo00357a021.

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Salaheldin, Abdellatif M. "Enaminonitriles in Heterocyclic Synthesis: Novel Synthesis of 3-Aminopyrroles and Pyrrolo[3,2-d]pyrimidine Derivatives." Zeitschrift für Naturforschung B 63, no. 5 (2008): 564–70. http://dx.doi.org/10.1515/znb-2008-0514.

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Several new 3-aminopyrrole derivatives have been synthesized from 3-substituted amino-2-phenylacrylonitriles using Thorpe-Ziegler cyclization. These substituted pyrroles are readily converted into 5H-pyrrolo[3,2-d]pyrimidines (9-deazapurines).
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Majumdar, K. C., and Shovan Mondal. "An expedient approach for the synthesis of pyrrolo[3,2-d]pyrimidines (9-deazaxanthines) and furo[3,2-d]pyrimidine via radical cyclization." Tetrahedron 65, no. 46 (2009): 9604–8. http://dx.doi.org/10.1016/j.tet.2009.09.059.

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El Kaïm, Laurent, Laurence Grimaud, and Simon Wagschal. "Toward Pyrrolo[2,3-d]pyrimidine Scaffolds." Journal of Organic Chemistry 75, no. 15 (2010): 5343–46. http://dx.doi.org/10.1021/jo100759b.

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Dissertations / Theses on the topic "Pyrrolo[3,2-d]pyrimidine"

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Xu, Kuiying. "Pyrrolo[2,3-d]pyrimidine, Pyrazolo[3,4-d]pyrimidine and Triazolo[4,5-d]pyrimidine nucleosides and oligonucleotides: Synthesis, physical properties and base-pairing = Pyrrolo[2,3-d]pyrimidin, Pyrazolo[3,4-d]pyrimidin und Triazolo[4,5-d]pyrimidin nucleoside und oligonucleotide: Synthese, physikalische Eigenschaften und Basenpaarung /." Osnabrück, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254557.

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Fossey, Christine. "Synthèse de nucléosides pyrimidiniques à visée antivirale (anti-sida) possédant un aglycone original : la thiéno (3,2-d) pyrimidine-2, 4-dione." Caen, 1992. http://www.theses.fr/1992CAEN4047.

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LIOU, AN-SYUN, and 劉安訓. "Design and Synthesis of Pyrrolo[3,2-d]pyrimidine-based Derivatives as Potential Agents for Alzheimer’s Disease." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/twum5f.

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Bambuch, Vítězslav. "C-Substituce polohy 7 pyrrolo[3,2-d ]pyrimidinů pomocí cross-coupling reakcí." Master's thesis, 2006. http://www.nusl.cz/ntk/nusl-366022.

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Brouillette, Yann. "Synthèse et fonctionnalisation sur support solide des aminopyrroles carboxylates." Thèse, 2005. http://hdl.handle.net/1866/16768.

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Marcotte, Félix-Antoine. "Synthèse et fonctionnalisation des 4-aminopyrrole-2-carboxylates." Thèse, 2004. http://hdl.handle.net/1866/14349.

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Books on the topic "Pyrrolo[3,2-d]pyrimidine"

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Scott, Andrew William. Preparation of fluorinated pyrrolo[2,3-d]pyrimidine. University of Birmingham, 1995.

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Book chapters on the topic "Pyrrolo[3,2-d]pyrimidine"

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Caravatti, G., J. Brüggen, E. Buchdunger, et al. "Pyrrolo[2,3-d]pyrimidine and Pyrazolo[3,4-d]pyrimidine Derivatives as Selective Inhibitors of the EGF Receptor Tyrosine Kinase." In Anticancer Agents. American Chemical Society, 2001. http://dx.doi.org/10.1021/bk-2001-0796.ch014.

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Gangjee, A., J. Yang, J. J. McGuire, and R. L. Kisliuk. "Effect of Bridge Truncation of Classical 2,4-Diamino-5-Substituted Furo [2,3-d] Pyrimidine and 2-Amino-4-Oxo-6-Substituted Pyrrolo [2,3-d] Pyrimidine on Antifolate Activity." In Chemistry and Biology of Pteridines and Folates. Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0945-5_75.

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Sircar, J. C., C. R. Kostlan, R. B. Gilbertsen, M. K. Dong, and W. A. Cetenko. "Pyrrolo[3,2-D]Pyrimidines, a New Class of Purine Nucleoside Phosphorylase (PNP) Inhibitors as Potential T-Cell Selective Immunosuppressive Agents." In Advances in Experimental Medicine and Biology. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4899-2638-8_9.

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"2H-Pyrrolo[3,4-b]quinoline to 4H-1-Benzothieno[3,2-d]-1,3-oxazine." In Substance Index Cyclic Compounds VIII, Tricyclic compounds II, edited by Büchel, Falbe, Hagemann, et al. Georg Thieme Verlag, 2000. http://dx.doi.org/10.1055/b-0035-114889.

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van der Westhuyzen, Aletta E., Liliya V. Frolova, Alexander Kornienko, and Willem A. L. van Otterlo. "The Rigidins: Isolation, Bioactivity, and Total Synthesis—Novel Pyrrolo[2,3- d ]Pyrimidine Analogues Using Multicomponent Reactions." In The Alkaloids: Chemistry and Biology. Elsevier, 2018. http://dx.doi.org/10.1016/bs.alkal.2017.12.003.

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Conference papers on the topic "Pyrrolo[3,2-d]pyrimidine"

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Dekhne, Aamod, Khushbu Shah, Gregory S. Ducker, et al. "Abstract 2992: Cellular pharmacodynamics of mitochondrial one-carbon metabolism-targeting 5-substituted pyrrolo[3,2-d]pyrimidine antifolates." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2992.

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Dekhne, Aamod, Khushbu Shah, Gregory S. Ducker, et al. "Abstract 2992: Cellular pharmacodynamics of mitochondrial one-carbon metabolism-targeting 5-substituted pyrrolo[3,2-d]pyrimidine antifolates." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2992.

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Dekhne, Aamod S., Gregory S. Ducker, Josephine Frühauf, et al. "Abstract 3980: Dual targeting mitochondrial and cytosolic one-carbon metabolism via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine antifolates." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-3980.

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Ning, Changwen, Aamod Dekhne, Md Junayed Nayeen, et al. "Abstract 4794: Targeting mitochondrial and cytosolic one carbon metabolism of pancreatic adenocarcinoma via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine analogs." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-4794.

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Ning, Changwen, Aamod Dekhne, Md Junayed Nayeen, et al. "Abstract 4794: Targeting mitochondrial and cytosolic one carbon metabolism of pancreatic adenocarcinoma via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine analogs." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-4794.

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Gangjee, Aleem, Khushbu Shah, Nicholas Dybdal-Hargreaves, Susan Mooberry, Anja Bastian, and Michael Ihnat. "Abstract 4857: Design and biological evaluation of substituted pyrrolo[3,2-d]pyrimidines as dual acting RTK and microtubule targeting agents." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4857.

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Soudy, Christelle, Emma Stanway, Bhavisha Patel та ін. "Abstract LB-99: Identification and characterization of small molecule thieno[3,2-d]pyrimidine inhibitors of Protein Kinase C iota (PKCι)". У Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-lb-99.

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Gangjee, Aleem, Sai Zhao, Lei Wang, et al. "Abstract 3823: 2-Methyl-6-substituted pyrrolo[2,3-d]pyrimidine classical antifolates as selective folate receptor substrates, glycinamide ribonucleotide formyltransferase inhibitors and antitumor agents." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3823.

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Desmoulin, Sita Kugel, Lei Wang, Larry Tait, et al. "Abstract 2528: Therapeutic targeting of a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by PCFT." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-2528.

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Shah, Khushbu, Aleem Gangjee, Roheeth Pavana, Dybdal-Hargreaves F. Nicholas, and Susuan Mooberry. "Abstract 3657: Preclinical evaluation of water-soluble pyrrolo[3,2-d]pyrimidines as single agents with tubulin and multiple receptor tyrosine kinase inhibition and as antitumor agents." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-3657.

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