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Relevant bibliographies by topics / Pyrrolo-Pyrimidine

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Academic literature on the topic 'Pyrrolo-Pyrimidine'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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Journal articles on the topic "Pyrrolo-Pyrimidine"

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Popa, Marcel Mirel, Emilian Georgescu, Mino R. Caira, et al. "Indolizines and pyrrolo[1,2-c]pyrimidines decorated with a pyrimidine and a pyridine unit respectively." Beilstein Journal of Organic Chemistry 11 (June 26, 2015): 1079–88. http://dx.doi.org/10.3762/bjoc.11.121.

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The three possible structural isomers of 4-(pyridyl)pyrimidine were employed for the synthesis of new pyrrolo[1,2-c]pyrimidines and new indolizines, by 1,3-dipolar cycloaddition reaction of their corresponding N-ylides generated in situ from their corresponding cycloimmonium bromides. In the case of 4-(3-pyridyl)pyrimidine and 4-(4-pyridyl)pyrimidine the quaternization reactions occur as expected at the pyridine nitrogen atom leading to pyridinium bromides and consequently to new indolizines via the corresponding pyridinium N-ylides. However, in the case of 4-(2-pyridyl)pyrimidine the steric h

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2

Selvakumar, Balaraman, and Kuppanagounder P. Elango. "Synthesis of Non-Glutamate-Type Pyrrolo[2,3-d]Pyrimidines via Direct Aminocarbonylation of Aryl Halides Using Solid Co2(CO)8 as a CO Source and Their Antibacterial Activity." Journal of Chemical Research 41, no. 4 (2017): 230–34. http://dx.doi.org/10.3184/174751917x14894997017658.

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The synthesis of pyrrolo[2,3-d]pyrimidine derivatives by direct aminocarbonylation was demonstrated using solid Co2(CO)8 as a CO source in an autoclave at elevated temperature by reacting an aryl halide scaffold with a variety of amines. Using this method, 12 non-glutamate-type pyrrolo[2,3-d]pyrimidine analogues were prepared. Some compounds exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria.

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Rogerio, Kamilla Rodrigues, Cedric Stephan Graebin, Luiza Helena Pinto Domingues, et al. "Novel Quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione Derivatives Against Chloroquine-resistant Plasmodium falciparum." Current Topics in Medicinal Chemistry 20, no. 2 (2020): 99–110. http://dx.doi.org/10.2174/1568026619666191019100711.

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Introduction: In this work DHPMs were combined with the quinoline nucleus to obtain new quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione compounds with improved antiplasmodial activity as well as decreased cytotoxicity. Nineteen quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione derivatives connected by a linker group to quinolone ring moieties with different substituents were synthesized and assayed against P. falciparum. Materials and Methods: Nineteen quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione derivatives connected by a linker group to quinoline ring moieties with different substituents were syn

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4

Zhou, Jing, Zhengtong Mao, Haokun Pan, and Xingxian Zhang. "Pd-Catalyzed highly selective and direct ortho C–H arylation of pyrrolo[2,3-d]pyrimidine derivatives." Organic Chemistry Frontiers 7, no. 2 (2020): 324–28. http://dx.doi.org/10.1039/c9qo01312a.

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Pd-Catalyzed one-pot direct ortho C–H arylation of pyrrolo[2,3-d]pyrimidine derivatives is reported. This protocol provides a variety of biphenyl-containing pyrrolo[2,3-d]pyrimidines in good to excellent yields.

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Mao, Zhengtong, Min Liu, Gaoyang Zhu, Jing Zhou, and Xingxian Zhang. "Transition-metal-free highly regioselective C–H acetoxylation of pyrrolo[2,3-d]pyrimidine derivatives." Organic Chemistry Frontiers 7, no. 18 (2020): 2696–702. http://dx.doi.org/10.1039/d0qo00702a.

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Transition-metal-free catalyzed direct C(sp<sup>2</sup>)–H acetoxylation of pyrrolo[2,3-d]pyrimidine derivatives is reported. This protocol provides a variety of acetoxylated pyrrolo[2,3-d]pyrimidines in good to excellent yields.

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Soto-Acosta, Ruben, Eunkyung Jung, Li Qiu, Daniel J. Wilson, Robert J. Geraghty, and Liqiang Chen. "4,7-Disubstituted 7H-Pyrrolo[2,3-d]pyrimidines and Their Analogs as Antiviral Agents against Zika Virus." Molecules 26, no. 13 (2021): 3779. http://dx.doi.org/10.3390/molecules26133779.

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Discovery of compound 1 as a Zika virus (ZIKV) inhibitor has prompted us to investigate its 7H-pyrrolo[2,3-d]pyrimidine scaffold, revealing structural features that elicit antiviral activity. Furthermore, we have demonstrated that 9H-purine or 1H-pyrazolo[3,4-d]pyrimidine can serve as an alternative core structure. Overall, we have identified 4,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidines and their analogs including compounds 1, 8 and 11 as promising antiviral agents against flaviviruses ZIKV and dengue virus (DENV). While the molecular target of these compounds is yet to be elucidated, 4,7-di

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Cawrse, Brian M., Nia’mani M. Robinson, Nina C. Lee, Gerald M. Wilson, and Katherine L. Seley-Radtke. "Structural and Biological Investigations for a Series of N-5 Substituted Pyrrolo[3,2-d]pyrimidines as Potential Anti-Cancer Therapeutics." Molecules 24, no. 14 (2019): 2656. http://dx.doi.org/10.3390/molecules24142656.

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Pyrrolo[3,2-d]pyrimidines have been studied for many years as potential lead compounds for the development of antiproliferative agents. Much of the focus has been on modifications to the pyrimidine ring, with enzymatic recognition often modulated by C2 and C4 substituents. In contrast, this work focuses on the N5 of the pyrrole ring by means of a series of novel N5-substituted pyrrolo[3,2-d]pyrimidines. The compounds were screened against the NCI-60 Human Tumor Cell Line panel, and the results were analyzed using the COMPARE algorithm to elucidate potential mechanisms of action. COMPARE analys

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Muzychka, Lyubov, Iryna Yaremchuk, Iryna Yaremchuk, and Oleg Smolii. "7-Substituted pyrrolo[2,3-d]pyrimidines for the synthesis of new 1-deazapyrimido[1,2,3-cd]purines." French-Ukrainian Journal of Chemistry 5, no. 2 (2017): 15–23. http://dx.doi.org/10.17721/fujcv5i2p15-23.

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Few examples of new heterocyclic 1-deazapyrimido[1,2,3-cd]purine derivatives were synthesized by intramolecular cyclization of methyl 7-(oxiran-2-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylates. The latter were obtained by iodolactonization of 7-allylpyrrolo[2,3-d]pyrimidine-6-carboxylic acids.

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El Kaïm, Laurent, Laurence Grimaud, and Simon Wagschal. "Toward Pyrrolo[2,3-d]pyrimidine Scaffolds." Journal of Organic Chemistry 75, no. 15 (2010): 5343–46. http://dx.doi.org/10.1021/jo100759b.

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Han, Yong Nam, and Myung Sook Chung. "A pyrrolo-pyrimidine alkaloid fromGlycyrrhiza uralensis." Archives of Pharmacal Research 13, no. 1 (1990): 103–4. http://dx.doi.org/10.1007/bf02857843.

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Dissertations / Theses on the topic "Pyrrolo-Pyrimidine"

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Xu, Kuiying. "Pyrrolo[2,3-d]pyrimidine, Pyrazolo[3,4-d]pyrimidine and Triazolo[4,5-d]pyrimidine nucleosides and oligonucleotides: Synthesis, physical properties and base-pairing = Pyrrolo[2,3-d]pyrimidin, Pyrazolo[3,4-d]pyrimidin und Triazolo[4,5-d]pyrimidin nucleoside und oligonucleotide: Synthese, physikalische Eigenschaften und Basenpaarung /." Osnabrück, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254557.

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KOURANY, LEFOLL ELLY, and Mary Païs. "Phloeodictines : nouvelles substances antibiotiques de type pyrrolo 1,2-a pyrimidine isolees de l'eponge neo-caledonienne phloeodictyon sp." Paris 11, 1992. http://www.theses.fr/1992PA112119.

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Une nouvelle famille de derives guanidiniques antibiotiques contenant au minimum 27 composes de type 6-hydroxy 1,2,3,4 tetrahydro-pyrrolo 1,2-a pyrimidinium, mis en evidence pour la premiere fois dans le domaine des substaces naturelles, a ete isolee de l'eponge neo-caledonienne phloeodictyon sp. Ces composes, denommes phloeodictines appartiennent a trois groupes a, b et c differant entre eux par la presence d'une double liaison #7#,#8 et/ou d'une chaine -s-(ch#2)#2-c=nh(nh#2) en position 7. La structure des phloeodictines a et b, obtenues sous forme pure, a ete determinee essentiellement grac

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Gilson, Pauline. "Caractérisation in vitro et in vivo de nouveaux agents pyrrolo-pyrimidine ciblant les microtubules pour le traitement des cancers." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV037.

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CARACTERISATION IN VITRO ET IN VIVO DE NOUVEAUX AGENTS PYRROLO-PYRIMIDINE CIBLANT LES MICROTUBULES POUR LE TRAITEMENT DES CANCERSEn dépit de l’émergence des thérapies ciblées et de l’immunothérapie, la chimiothérapie reste un gold-standard pour le traitement de nombreux cancers. Parmi les agents chimiothérapeutiques conventionnels, les poisons du fuseau interférant avec la dynamique des microtubules (taxanes, vinca-alcaloïdes) sont très largement utilisés. Cependant, leurs nombreux effets indésirables et l’émergence de chimiorésistance limitent leur efficacité et soulignent la nécessité d’iden

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LIOU, AN-SYUN, and 劉安訓. "Design and Synthesis of Pyrrolo[3,2-d]pyrimidine-based Derivatives as Potential Agents for Alzheimer’s Disease." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/twum5f.

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Brouillette, Yann. "Synthèse et fonctionnalisation sur support solide des aminopyrroles carboxylates." Thèse, 2005. http://hdl.handle.net/1866/16768.

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Books on the topic "Pyrrolo-Pyrimidine"

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Scott, Andrew William. Preparation of fluorinated pyrrolo[2,3-d]pyrimidine. University of Birmingham, 1995.

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Book chapters on the topic "Pyrrolo-Pyrimidine"

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Caravatti, G., J. Brüggen, E. Buchdunger, et al. "Pyrrolo[2,3-d]pyrimidine and Pyrazolo[3,4-d]pyrimidine Derivatives as Selective Inhibitors of the EGF Receptor Tyrosine Kinase." In Anticancer Agents. American Chemical Society, 2001. http://dx.doi.org/10.1021/bk-2001-0796.ch014.

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Gangjee, A., J. Yang, J. J. McGuire, and R. L. Kisliuk. "Effect of Bridge Truncation of Classical 2,4-Diamino-5-Substituted Furo [2,3-d] Pyrimidine and 2-Amino-4-Oxo-6-Substituted Pyrrolo [2,3-d] Pyrimidine on Antifolate Activity." In Chemistry and Biology of Pteridines and Folates. Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0945-5_75.

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3

Tominaga, Y. "[8π+3π]-Cycloaddition Reaction of a Pyrrolo[1,2-c]pyrimidine with 1,3-Dibromo-1,3-diphenylacetone." In Six-Membered Hetarenes with Two Unlike or More than Two Heteroatoms and Fully Unsaturated Larger-Ring Heterocycles. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-017-01679.

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van der Westhuyzen, Aletta E., Liliya V. Frolova, Alexander Kornienko, and Willem A. L. van Otterlo. "The Rigidins: Isolation, Bioactivity, and Total Synthesis—Novel Pyrrolo[2,3- d ]Pyrimidine Analogues Using Multicomponent Reactions." In The Alkaloids: Chemistry and Biology. Elsevier, 2018. http://dx.doi.org/10.1016/bs.alkal.2017.12.003.

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Conference papers on the topic "Pyrrolo-Pyrimidine"

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Dekhne, Aamod, Khushbu Shah, Gregory S. Ducker, et al. "Abstract 2992: Cellular pharmacodynamics of mitochondrial one-carbon metabolism-targeting 5-substituted pyrrolo[3,2-d]pyrimidine antifolates." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2992.

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Dekhne, Aamod, Khushbu Shah, Gregory S. Ducker, et al. "Abstract 2992: Cellular pharmacodynamics of mitochondrial one-carbon metabolism-targeting 5-substituted pyrrolo[3,2-d]pyrimidine antifolates." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2992.

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Gangjee, Aleem, Sai Zhao, Lei Wang, et al. "Abstract 3823: 2-Methyl-6-substituted pyrrolo[2,3-d]pyrimidine classical antifolates as selective folate receptor substrates, glycinamide ribonucleotide formyltransferase inhibitors and antitumor agents." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3823.

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Dekhne, Aamod S., Gregory S. Ducker, Josephine Frühauf, et al. "Abstract 3980: Dual targeting mitochondrial and cytosolic one-carbon metabolism via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine antifolates." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-3980.

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Desmoulin, Sita Kugel, Lei Wang, Larry Tait, et al. "Abstract 2528: Therapeutic targeting of a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by PCFT." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-2528.

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Gangjee, Aleem, Lalit Kumar, Christina Cherian, Steven Orr, Erika Etnyre, and Larry H. Matherly. "Abstract 4765: Synthesis and evaluation of nonclassical 6-substituted pyrrolo[2,3-d]pyrimidine antifolates: Role of terminal amino acid moiety in membrane transport and antitumor activity." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4765.

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Cherian, Christina, Sita Kugel Desmoulin, Lei Wang, et al. "Abstract 3826: Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3826.

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Ning, Changwen, Aamod Dekhne, Md Junayed Nayeen, et al. "Abstract 4794: Targeting mitochondrial and cytosolic one carbon metabolism of pancreatic adenocarcinoma via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine analogs." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-4794.

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Ning, Changwen, Aamod Dekhne, Md Junayed Nayeen, et al. "Abstract 4794: Targeting mitochondrial and cytosolic one carbon metabolism of pancreatic adenocarcinoma via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine analogs." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-4794.

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Cherian, Christina, Yiqiang Wang, Shermaine Mitchell-Ryan та ін. "Abstract 5493: Tumor-targeting with novel non-benzoyl 6-substituted pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition ofde novopurine nucleotide biosynthesis." У Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5493.

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