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Relevant bibliographies by topics / Pyrrolo pyrimidinone

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Academic literature on the topic 'Pyrrolo pyrimidinone'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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Journal articles on the topic "Pyrrolo pyrimidinone"

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Mohamed, Mosaad, Ramdan El-Domany, and Rania Abd El-Hameed. "Synthesis of certain pyrrole derivatives as antimicro-bial agents." Acta Pharmaceutica 59, no. 2 (2009): 145–58. http://dx.doi.org/10.2478/v10007-009-0016-9.

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Synthesis of certain pyrrole derivatives as antimicro-bial agentsIn an effort to establish new pyrroles and pyrrolo[2,3-d] pyrimidines with improved antimicrobial activity we report here the synthesis andin vitromicrobiological evaluation of a series of pyrrole derivatives. A series of new 2-aminopyrrole-3-carbonitriles (1a-d) were synthesized from the reaction of benzoin, primary aromatic amines and malononitrile, from which a number of pyrrole derivatives (2a-dto5a-d) and pyrrolo[2,3-d]pyrimidines (6a-dto10a, d) were synthesized. Thein vitroantimicrobial testing of the synthesized compounds

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B, S. a. l. i. e. v. a. G., J. u. m. a. e. v. a. M. E, K. h. o. l. i. k. o. v. T. S, A. i. s. a. H. A, and B. o. z. o. r. o. v. K. h. A. "SYNTHESIS, ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORY ACTIVITY OF NOVEL TRICYCLIC 1-PHENYL-1,6,7,8-TETRAHYDRO-4H- PYRAZOLO[3,4-d]PYRROLO[1,2-a]PYRIMIDIN-4-ONE." 2022-yil, 3-son (133/1) ANIQ FANLAR SERIYASI 1, no. 125/2 (2021): 1–7. http://dx.doi.org/10.59251/2181-1296.v1.1252.948.

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A convenient synthesis of novel tricyclic annulated pyrimidinone, namely 1-phenyl- 1,6,7,8-tetrahydro-4 H -pyrazolo[3,4- d ]pyrrolo[1,2- a ]pyrimidin-4-one was described herein. Cyclization was provided via A-ring modification of deoxyvasicinone (natural product). Biological activities of this compound reveal promising acetylcholinesterase inhibitory activity of 82.48±0.76 %, while showed moderate butyrylcholinesterase inhibitory activity

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Huynh, Van Truong, and Huu Hiep Nguyen. "Bioactive Compounds of Bacillus subtilis strain B237 isolated from the endophytic bacteria in Houttuynia cordata Thunb by Gas Chromatography-Mass Spectrometry." Pharmaceutical and Chemical Journal 7, no. 4 (2020): 1–7. https://doi.org/10.5281/zenodo.13955164.

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To identify some compounds by GC-MS from the biologically active compounds have been identified in hexane-acetone, acetone-methanol and ethyl acetate organic solvents. The determination of bioactive chemical compounds is based on peak area, retention time, molecular weight and molecular formula. From the endophytic bacteria of <em>Houttuynia cordata </em>Thunb from <em>Bacillus subtilis </em>strain B237 having antibacterial activity against <em>Staphylococcus aureus</em> from people’s furuncles. <em>Houttuynia cordata </em>Thunb was collected in Kien Giang province, bacteria were isolate

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Panda, Ashish Kumar, Ruchi Bharti, Ajay Thakur, Monika Verma, and Renu Sharma. "Microwave-Assisted Multicomponent Synthesis of Pyrrolo [2, 3-d] Pyrimidinone Derivatives and Their DFT Calculations." Der Pharma Chemica 15, no. 3 (2023): 10. https://doi.org/10.5281/zenodo.13318888.

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Herein we have reported a green and environmentally benign methodology for synthesizing novel pyrrolo[2,3-d] pyrimidine derivatives under microwave-assisted reaction conditions. The desired product was obtained with an excellent yield (80-90%) within 30 minutes only. The characteristic features of this protocol were the use of green reaction conditions, high atom economy, less reaction time, excellent yields, no use of specific purification processes, no column chromatography, etc. Later, theoretical studies like DFT were also performed on each newly synthesized product (4a-e) using B3LYP (Bec

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Ruchi, Bharti, and Ashish Kumar Panda. "Microwave-Assisted Multicomponent Synthesis of Pyrrolo [2, 3-d] Pyrimidinone Derivatives and Their DFT Calculations." DER PHARMA CHEMICA 15, no. 3 (2023): 10. https://doi.org/10.4172/0975-413X.15.3.52-61.

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Herein we have reported a green and environmentally benign methodology for synthesizing novel pyrrolo[2,3-d] pyrimidine derivatives under microwave-assisted reaction conditions. The desired product was obtained with an excellent yield (80-90%) within 30 minutes only. The characteristic features of this protocol were the use of green reaction conditions, high atom economy, less reaction time, excellent yields, no use of specific purification processes, no column chromatography, etc. Later, theoretical studies like DFT were also performed on each newly synthesized product (4a-e) using B3LYP (Bec

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Panda, Ashish Kumar, Bharti Ruchi, Ajay Thakur, Monika Verma, and Renu Sharma. "Microwave-Assisted Multicomponent Synthesis of Pyrrolo [2, 3-d] Pyrimidinone Derivatives and Their DFT Calculations." Der Pharma Chemica 15, no. 3 (2023): 10. https://doi.org/10.5281/zenodo.10951900.

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Herein we have reported a green and environmentally benign methodology for synthesizing novel pyrrolo[2,3-d] pyrimidine derivatives under microwave-assisted reaction conditions. The desired product was obtained with an excellent yield (80-90%) within 30 minutes only. The characteristic features of this protocol were the use of green reaction conditions, high atom economy, less reaction time, excellent yields, no use of specific purification processes, no column chromatography, etc. Later, theoretical studies like DFT were also performed on each newly synthesized product (4a-e) using B3LYP (Bec

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Vaskevych, Alla, Nataliia Savinchuk, and Mykhailo Vov. "Synthesis of pyrrolo(pyrido)[1,2-a]quinazolinones and their benzoannulated analogues: An overview." Current Chemistry Letters 14, no. 3 (2025): 507–32. https://doi.org/10.5267/j.ccl.2025.3.005.

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Angular pyrrolo(pyrido)[1,2-a]quinazolinones, being structurally isomeric to linear pyrrolo(pyrido)[2,1-b]quinazolinone alkaloids, are attractive molecular systems for both synthetic transformations and targeted biomedical research. The pyrrolo(pyrido)[1,2-a]quinazolinone scaffold has proven to be quite effective in the search for compounds with a wide range of pharmacological activities, e.g. anti-inflammatory, antioxidant, antibacterial, antiarrhythmic, and inhibitors of important biotargets. The present review summarises the methods for the synthesis of pyrrolo(pyrido)[1,2-a]quinazolinones

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Bernáth, Gábor, Ferenc Csende, Zsolt Böcskei, Pál Sohár, and Géza Stájer. "Preparation of Cycloalkano[c]pyridazinoens and Cycloalkane-condensed Pyrrolo[1,2-a]imidazolone, -pyrimidinone and -[1,3]diazepinone Stereoisomers." HETEROCYCLES 45, no. 2 (1997): 323. http://dx.doi.org/10.3987/com-96-7673.

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Tretyakov, N. A., M. V. Dmitriev, and A. N. Maslivets. "Synthesis of spiro(pyrrol-2,5'-pyrrolo[2,3-<i>d</i>]pyrimidine)2',4',5,6'-tetraones by the reaction of pyrrolo[2,1-<i>c</i>][1,4]oxazinetriones with 6-aminopyrimidine-2,4-diones." Журнал органической химии 59, no. 2 (2023): 180–86. http://dx.doi.org/10.31857/s0514749223020039.

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8-Aroyl-3,4-dihydro-1 H -pyrrolo[2,1- c ][1,4]oxazine-1,6,7-triones react with 6-aminopyrimidine-2,4(1 H ,3 H )diones to form 3-aroyl-4-hydroxy-1-(2-hydroxyalkyl)spiro(pyrrole-2,5'-pyrrolo[2,3- d ]pyrimidine)2',4',5,6'(1 H ,1' H ,3' H ,7' H )-tetraones, the structure of which was confirmed by X-ray diffraction analysis.

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Song, Buer, Zarifa Murtazaeva, Lifei Nie, et al. "Pyrrolopyrimidines: Design, Synthesis and Antitumor Properties of Novel Tricyclic Pyrrolo [2,3-d]pyrimidine Derivatives." Molecules 30, no. 14 (2025): 2917. https://doi.org/10.3390/molecules30142917.

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The pyrrolo[2,3-d]pyrimidine (7-deazapurine) scaffold is a unique heterocyclic system included in the composition of most nucleotides. In this study, series of the pyrrolo[2,3-d]pyrimidine-imines and 3-halo-substituted pyrrolo[2,3-d]pyrimidines were designed and prepared in high yields. Condensed pyrimidines are obtained via carbonyl-amine condensation and carbon-halogen bond formation. Pyrrolo[2,3-d]pyrimidine-imines containing a bromine substituent at position C-4 of the phenyl ring and azepine side-ring exhibited superior antitumor activity on the colon cancer HT-29 cell line; IC50 values w

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Dissertations / Theses on the topic "Pyrrolo pyrimidinone"

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Drexler, Johannes [Verfasser]. "Neue Zytostatische Nukleoside : Syntheserouten zu Trifluormethylierten Pyrrolo[2,3-d]pyrimidinen / Johannes Drexler." Konstanz : Bibliothek der Universität Konstanz, 2015. http://d-nb.info/1088797377/34.

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Xu, Kuiying. "Pyrrolo[2,3-d]pyrimidine, Pyrazolo[3,4-d]pyrimidine and Triazolo[4,5-d]pyrimidine nucleosides and oligonucleotides: Synthesis, physical properties and base-pairing = Pyrrolo[2,3-d]pyrimidin, Pyrazolo[3,4-d]pyrimidin und Triazolo[4,5-d]pyrimidin nucleoside und oligonucleotide: Synthese, physikalische Eigenschaften und Basenpaarung /." Osnabrück, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254557.

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KOURANY, LEFOLL ELLY, and Mary Païs. "Phloeodictines : nouvelles substances antibiotiques de type pyrrolo 1,2-a pyrimidine isolees de l'eponge neo-caledonienne phloeodictyon sp." Paris 11, 1992. http://www.theses.fr/1992PA112119.

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Une nouvelle famille de derives guanidiniques antibiotiques contenant au minimum 27 composes de type 6-hydroxy 1,2,3,4 tetrahydro-pyrrolo 1,2-a pyrimidinium, mis en evidence pour la premiere fois dans le domaine des substaces naturelles, a ete isolee de l'eponge neo-caledonienne phloeodictyon sp. Ces composes, denommes phloeodictines appartiennent a trois groupes a, b et c differant entre eux par la presence d'une double liaison #7#,#8 et/ou d'une chaine -s-(ch#2)#2-c=nh(nh#2) en position 7. La structure des phloeodictines a et b, obtenues sous forme pure, a ete determinee essentiellement grac

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Gilson, Pauline. "Caractérisation in vitro et in vivo de nouveaux agents pyrrolo-pyrimidine ciblant les microtubules pour le traitement des cancers." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV037.

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CARACTERISATION IN VITRO ET IN VIVO DE NOUVEAUX AGENTS PYRROLO-PYRIMIDINE CIBLANT LES MICROTUBULES POUR LE TRAITEMENT DES CANCERSEn dépit de l’émergence des thérapies ciblées et de l’immunothérapie, la chimiothérapie reste un gold-standard pour le traitement de nombreux cancers. Parmi les agents chimiothérapeutiques conventionnels, les poisons du fuseau interférant avec la dynamique des microtubules (taxanes, vinca-alcaloïdes) sont très largement utilisés. Cependant, leurs nombreux effets indésirables et l’émergence de chimiorésistance limitent leur efficacité et soulignent la nécessité d’iden

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Ejjoummany, Abdelaziz. "Design et fonctionnalisation d’hétérocycles originaux de type bicycliques [5-5] et tricycliques [6-5-6] à visée thérapeutique potentielle." Thesis, Orléans, 2020. http://www.theses.fr/2020ORLE3141.

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L’accès à de nouveaux composés hétérocycliques originaux biologiquement actifs, constitue l’un des principaux objectifs de notre groupe de recherche. Dans ce contexte, les travaux de cette thèse ont pour but principal, la conception de trois nouvelles familles de composés hétérocycliques contenant un motif pyrazolique susceptibles de présenter des activités biologiques, à savoir les pyrido[1',2':1,5]pyrazolo[4,3-d]pyrimidine, les pyrrolo[3,4-c]pyrazoles et les pyrazolo[5,1-b]thiazoles. Ce manuscrit est essentiellement dédié à un travail de méthodologie décrivant les différentes voies d’accès à

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Aquino, Estefania da Costa. "Aplicação de 5-bromo-1,1,1-trifluor-4-metoxipent-3-en-2-ona na síntese de pirróis, pirazóis, pirimidinas e 1,2,3-triazóis." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/4275.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>This thesis reports the synthesis of various series of trifluoromethyl substituted nitrogenated heterocycles, such as pyrroles, pyrazoles, pyrimidines and 1,2,3-triazoles, exploiting the synthetic versatility of 5-bromo-1,1,1-trifluoro-4-methoxypent-3-en-2-one in reactions with nitrogenated nucleophiles. In this way, synthesis of a novel series of 4-amino-3-trifluoromethyl-1H-N-substituted pyrroles was performed through two reaction steps. In the first stage is an addition reaction of primary or secondary amine in the 4-position

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LIOU, AN-SYUN, and 劉安訓. "Design and Synthesis of Pyrrolo[3,2-d]pyrimidine-based Derivatives as Potential Agents for Alzheimer’s Disease." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/twum5f.

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You-JyunChen and 陳柚鈞. "Adsorption and Reactions of Pyrrole and Pyrimidine on Cu(100) and O/Cu(100)." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/57svrv.

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Brouillette, Yann. "Synthèse et fonctionnalisation sur support solide des aminopyrroles carboxylates." Thèse, 2005. http://hdl.handle.net/1866/16768.

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Books on the topic "Pyrrolo pyrimidinone"

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Scott, Andrew William. Preparation of fluorinated pyrrolo[2,3-d]pyrimidine. University of Birmingham, 1995.

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Eland, John H. D., and Raimund Feifel. Conjugated and aromatic molecules. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198788980.003.0006.

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In the vast majority of conjugated and aromatic molecules, the outermost occupied orbitals are either of π‎ character or non-bonding lone pairs belonging to heteroatoms. These are the orbitals from which double ionisation gives rise to most of the distinct bands that can be discerned in their spectra. Double photoionisation spectra of ethylene, butadiene, pyrrole, furan, thiophene, benzene, hexafluorobenzene, toluene, pyridine, pyrazine, pyrimidine, pyridazine, naphthalene, azulene, quinoline, biphenyl, TDME, iron pentacarbonyl, ferrocene, and TMPPD are presented with analysis where possible.

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Book chapters on the topic "Pyrrolo pyrimidinone"

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Caravatti, G., J. Brüggen, E. Buchdunger, et al. "Pyrrolo[2,3-d]pyrimidine and Pyrazolo[3,4-d]pyrimidine Derivatives as Selective Inhibitors of the EGF Receptor Tyrosine Kinase." In Anticancer Agents. American Chemical Society, 2001. http://dx.doi.org/10.1021/bk-2001-0796.ch014.

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Gangjee, A., J. Yang, J. J. McGuire, and R. L. Kisliuk. "Effect of Bridge Truncation of Classical 2,4-Diamino-5-Substituted Furo [2,3-d] Pyrimidine and 2-Amino-4-Oxo-6-Substituted Pyrrolo [2,3-d] Pyrimidine on Antifolate Activity." In Chemistry and Biology of Pteridines and Folates. Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0945-5_75.

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Kumari, K. Meena, L. Yamini, and M. Vijjulatha. "Study about 3D QSAR of Pyrrolo Pyrimidine and Thieno Pyrimidines as Human Thymidylate Synthase Inhibitors." In Current Topics on Chemistry and Biochemistry Vol. 8. B P International (a part of SCIENCEDOMAIN International), 2023. http://dx.doi.org/10.9734/bpi/ctcb/v8/9000f.

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Tominaga, Y. "[8π+3π]-Cycloaddition Reaction of a Pyrrolo[1,2-c]pyrimidine with 1,3-Dibromo-1,3-diphenylacetone." In Six-Membered Hetarenes with Two Unlike or More than Two Heteroatoms and Fully Unsaturated Larger-Ring Heterocycles. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-017-01679.

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van der Westhuyzen, Aletta E., Liliya V. Frolova, Alexander Kornienko, and Willem A. L. van Otterlo. "The Rigidins: Isolation, Bioactivity, and Total Synthesis—Novel Pyrrolo[2,3- d ]Pyrimidine Analogues Using Multicomponent Reactions." In The Alkaloids: Chemistry and Biology. Elsevier, 2018. http://dx.doi.org/10.1016/bs.alkal.2017.12.003.

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Conference papers on the topic "Pyrrolo pyrimidinone"

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Dekhne, Aamod, Khushbu Shah, Gregory S. Ducker, et al. "Abstract 2992: Cellular pharmacodynamics of mitochondrial one-carbon metabolism-targeting 5-substituted pyrrolo[3,2-d]pyrimidine antifolates." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2992.

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Dekhne, Aamod, Khushbu Shah, Gregory S. Ducker, et al. "Abstract 2992: Cellular pharmacodynamics of mitochondrial one-carbon metabolism-targeting 5-substituted pyrrolo[3,2-d]pyrimidine antifolates." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2992.

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Gangjee, Aleem, Sai Zhao, Lei Wang, et al. "Abstract 3823: 2-Methyl-6-substituted pyrrolo[2,3-d]pyrimidine classical antifolates as selective folate receptor substrates, glycinamide ribonucleotide formyltransferase inhibitors and antitumor agents." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3823.

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Dekhne, Aamod S., Gregory S. Ducker, Josephine Frühauf, et al. "Abstract 3980: Dual targeting mitochondrial and cytosolic one-carbon metabolism via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine antifolates." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-3980.

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Desmoulin, Sita Kugel, Lei Wang, Larry Tait, et al. "Abstract 2528: Therapeutic targeting of a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by PCFT." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-2528.

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Gangjee, Aleem, Lalit Kumar, Christina Cherian, Steven Orr, Erika Etnyre, and Larry H. Matherly. "Abstract 4765: Synthesis and evaluation of nonclassical 6-substituted pyrrolo[2,3-d]pyrimidine antifolates: Role of terminal amino acid moiety in membrane transport and antitumor activity." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4765.

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Cherian, Christina, Sita Kugel Desmoulin, Lei Wang, et al. "Abstract 3826: Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3826.

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Ning, Changwen, Aamod Dekhne, Md Junayed Nayeen, et al. "Abstract 4794: Targeting mitochondrial and cytosolic one carbon metabolism of pancreatic adenocarcinoma via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine analogs." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-4794.

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Ning, Changwen, Aamod Dekhne, Md Junayed Nayeen, et al. "Abstract 4794: Targeting mitochondrial and cytosolic one carbon metabolism of pancreatic adenocarcinoma via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine analogs." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-4794.

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Wilson, Mike R., Manasa P. Ravindraa, Adrianne Wallace-Povirk, et al. "Abstract 4791: Targeting ovarian cancer with novel 6-substituted pyrrolo [2,3-d] pyrimidine fluorinated antifolates via cellular uptake by folate receptor á and the proton-coupled folate transporter." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4791.

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