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Relevant bibliographies by topics / Pyruvate kinase M2 (PKM2) / Dissertations / Theses

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Dissertations / Theses on the topic 'Pyruvate kinase M2 (PKM2)'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Gao, Xueliang. "Nuclear Pyruvate Kinase M2 Functional Study in Cancer Cells." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/biology_diss/89.

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Cancer cells take more glucose to provide energy and phosphoryl intermediates for cancer progression. Meanwhile, energy-provider function of mitochondria in cancer cells is disrupted. This phenomenon is so-called Warburg effect, which is discovered over eighty years ago. The detail mechanisms for Warburg effect are not well defined. How glycolytic enzymes contribute to cancer progression is not well known. PKM2 is a glycolytic enzyme dominantly localized in the cytosol, catalyzing the production of ATP from PEP. In this study, we discovered that there were more nuclear PKM2 expressed in highly

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2

Bahr, Brigham L. "Different Expression of Placental Pyruvate Kinase M2 in Normal, Preeclamptic, and Intrauterine Growth Restriction Pregnancies." BYU ScholarsArchive, 2014. https://scholarsarchive.byu.edu/etd/3901.

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This thesis will be organized into two chapters discussing the placental expression of two proteins, pyruvate kinase M2 (PKM2) and heat shock protein 27 (HSP 27), in human placentas. Understanding the mechanisms of placental metabolism in healthy and diseased placentas helps us understand how placenta disorders occur and how we can treat these disorders. The goal is to investigate these proteins to gain an understanding of their roles in placental disorders and help decrease maternal and fetal mortality rates. Chapter one covers the background of pyruvate kinase M2 (PKM2) in cancer and embryon

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3

Kimball, Rebecca Lutz. "The Role of Hypoxia on Pyruvate Kinase M2, mammalian Target of Rapamycin, Mitochondrial Function, and Cell Invasion in the Trophoblast." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/5723.

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This thesis will be organized into two chapters discussing the role of hypoxia in the human placenta. The goal of this thesis is to characterize pyruvate kinase M2, mammalian target of rapamycin, mitochondrial function, and cell invasion in hypoxic conditions in the trophoblast. Understanding the mechanisms of placental metabolism can lead to further treatments for placental diseases. Chapter one covers the background of intrauterine growth restriction, hypoxia, placental metabolism, and pyruvate kinase M2 (PKM2). Little is currently understood about the role of the mitochondria in placental d

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4

Mitchell, Rosie. "The regulation of human M2 pyruvate kinase." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/21690.

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Pyruvate kinase catalyses the final step in glycolysis and is responsible for net ATP production. There are four pyruvate kinase isoforms expressed in humans; LPYK, RPYK, M1PYK and M2PYK. The allosteric enzyme M2PYK plays an important role in cancer cell metabolism and is subject to complex regulation by numerous naturally occurring small-molecule metabolites. Post-translational modifications have also been found to play a key role in the regulation of M2PYK, among these cysteine oxidation. This thesis describes the production and characterisation of M2PYK cysteine point mutants in order to in

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5

Hasan, Diya [Verfasser]. "Hypoxic regulation and selective silencing of pyruvate kinase isoforms PKM1 and PKM2 by siRNA / Diya Hasan." Gießen : Universitätsbibliothek, 2012. http://d-nb.info/1064024580/34.

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6

Dayton, Talya Lucia. "Examining the roles of the pyruvate kinase isoforms, PKMI1 and PKM2, in systemic metabolism and tumor development." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104176.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2016.<br>Cataloged from PDF version of thesis. Vita.<br>Includes bibliographical references.<br>Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of pyruvate kinase, and PKM2 expression is closely linked to embryogenesis, tissue regeneration, and cancer. PKM1 expression, on the other hand, is restricted mostly to skeletal muscle, heart, and brain. To interrogate the functional requirement for PKM1 or PKM2 during development and tissue homeostasis, we generated germline PKM1 (Pkm1-/-) o

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7

Kumar, Y. "Clinical review and experimental evaluation of tumour M2-pyruvate kinase in pancreatic cancer." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/17418/.

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The treatment of pancreatic cancer is challenging. Patients are often beyond curative surgical therapy and palliative treatment with chemotherapy provides limited benefit. New markers of cancer activity and therapeutic targets are required. This thesis has firstly reviewed the available literature on Tumour M2-PK, a dimeric form of M2 isoenzyme of pyruvate kinase, in GI cancer and carried out a meta-analysis of the clinical data on pancreatic cancer. Experimental work evaluated the measurement of M2-pyruvate kinase in human pancreatic cancer cell lines with altered microenvironment (hypoxia, a

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8

Zaccaro, Cristina <1987&gt. "Evaluation of Tumor M2 Pyruvate Kinase and Endocannabinoid System Expression in Colorectal Preneoplastic and Neoplastic Lesions: Possible Use for non Invasive Diagnosis." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7357/.

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Colorectal cancer (CRC) is a multistep process that goes through adenoma-carcinoma sequence. Many forms of CRC may be prevented by routine control, which can detect precancerous neoplasm before they undergo malignant transformation (123). For this reasons we hypothesized that a combination of simple faecal tests, may help to identify patients with higher risk of adenomas and/or CRC. The aim of this study is to clarify whether FOBT, enzyme Tumor M2-PK and endocannabinoid system molecules (CB1, CB2, FAAH), could represent diagnostic non-invasive markers, alone or in combination, for early diagno

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9

Lavik, Andrew R. "The Role of Inositol 1,4,5-Trisphosphate Receptor-Interacting Proteins in Regulating Inositol 1,4,5-Trisphosphate Receptor-Dependent Calcium Signals and Cell Survival." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1448532307.

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10

Dharaneeswaran, Harita. "Pyruvate kinase M2 (PKM2), a glycolytic enzyme, is required to maintain vascular barrier function." Thesis, 2017. https://hdl.handle.net/2144/23713.

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RATIONALE - Metabolic enzymes, like pyruvate kinase M2 (PKM2), play an essential role in altering endothelial cell (EC) phenotypes and behavior. Extensive research has elucidated the function of PKM2, a rate-limiting glycolytic enzyme, in the context of cancer cells and in activated immune cells, but its role in EC biology is only newly emerging. Recent findings show PKM2 acts as a key regulator of angiogenesis. Where exogenous circulating PKM2 induces EC cell proliferation leading to increased tumor angiogenesis and growth. Also, PKM2 deficient ECs exhibit decreased proliferation and migratio

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11

Li, Liangwei. "Extracellular Pyruvate Kinase M2 regulates tumor angiogenesis." 2014. http://scholarworks.gsu.edu/biology_diss/141.

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Pyruvate kinase M2 (PKM2) has been studied for decades on its role in cancer metabolism. Recently, PKM2 is highlighted again for its new function: promoting gene transcription by acting as a protein kinase. Moreover, the PKM2 levels in patient circulation have been used as a diagnostic marker for many types of cancers. However, it remains unclear whether PKM2 in blood circulation has any physiological or pathological function. In my dissertation, I demonstrate that PKM2 released from cancer cells facilitates tumor growth by promoting tumor angiogenesis. Our experiments show that PKM2 promotes

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12

Chung, Yi, and 鍾怡. "The role of Pyruvate Kinase M2 in Chronic myelogenous Leukemia progression." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/52516784838481385354.

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碩士<br>國立陽明大學<br>醫學生物技術暨檢驗學系<br>104<br>Chronic myelogenous leukemia (CML) is a type of cancer that begins in certain bone marrow blood-forming cells. It is a form of leukemia characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. We used the gene set enrichment analysis (GSEA) study and found an important glycolytic enzyme, Pyruvate kinase M2 (PKM2) that regulates the gene pattern and is correlated with the leukemia stem cell (LSC) population (Lin- CD34 -/+) in CML microarray result. PKM2 is a gly

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13

Zhang, Yinwei. "Functions of Extracellular Pyruvate Kinase M2 in Tissue Repair and Regeneration." 2016. http://scholarworks.gsu.edu/biology_diss/166.

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Pyruvate kinase M2 (PKM2) is a glycolytic enzyme expressed in highly proliferating cells. Studies of PKM2 have been focused on its function of promoting cell proliferation in cancer cells. Our laboratory previously discovered that extracellular PKM2 released from cancer cells promoted angiogenesis by activating endothelial cell proliferation and migration. PKM2 activated endothelial cells through integrin αvβ3. Angiogenesis and myofibroblast differentiation are key processes during wound healing. In this dissertation, I demonstrate that extracellular PKM2 released from activated neutrophils pr

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14

Liu, Hsin-Yi, and 劉欣怡. "Nuclear pyruvate kinase M2 induces tumor repopulation to strive against glucose depletion stress." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/84908354611254268179.

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碩士<br>國立臺灣大學<br>生化科學研究所<br>103<br>The reprogramming of cancer metabolism is recognized as the Warburg effect, which demonstrates that cancer cells rely on aerobic glycolysis for energy generation. However, cancer cells are generally glucose deprived due to rapid proliferation and poor vascularization, hence cancer cells are forced to cope with glucose depletion stress and survive. Previous studies revealed that cancer cells manipulate the Warburg effect, gluconeogenesis pathway, migration ability, ER stress and cancer stem cell phenotypes in response to glucose depletion. Focus on the correlat

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15

Shih, Pei-Yu, and 施姵妤. "Influence of anti-colorectal cancer phytochemicals on Pyruvate Kinase M2 in SW620 cell line." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/52208736256195282884.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>101<br>Colorectal cancer (CRC) is the most common cancer in Taiwan and the incidence of CRC was dramatically raised during the past few decades. Recent studies demonstrated that pyruvate kinase M2 (PKM2) is the predominant PK isoform in tumor and supports growth advantage in tumorigenesis. In the cytoplasm, high activity PKM2 helps to generate enough energy and low activity PKM2 satisfies the anabolic demands of macromolecular biosynthesis. In addition to well-established role in the metabolic reprogramming in the cytoplasm, PKM2 is also shown to participate in regul

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16

Chen, Ju-Hsuan, and 陳儒萱. "Hepatitis B Virus Large Surface Protein Promotes Warburg Effect through Binding to Pyruvate Kinase Isoenzyme M2." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/577z8n.

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