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Journal articles on the topic 'Q-Absorbance Ratio method'

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Published: 5 June 2025

Last updated: 2 August 2025

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1

Kamal, Shah, and Mishra Pradeep. "Simultaneous estimation of metoprolol tartrate and amlodipine besylate by absorbance ratio method." Journal of Indian Chemical Society Vol. 96, Jun 2019 (2019): 711–15. https://doi.org/10.5281/zenodo.5647923.

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Institute of Pharmaceutical Research, GLA University, 17 Km Stone, NH-2, Mathura-Delhi Road, P.O. Chaumuhan, Mathura-281 406, Uttar Pradesh, India <em>E-mail</em>: kamal0603@gmail.com, pmishra51@rediffmail.com <em>Manuscript received online 30 January 2019, revised 25 April 2019, accepted 07 May 2019</em> A simple and cost-effective spectrophotometric method is developed for the determination of metoprolol tartrate and amlodipine besylate in bulk drug and tablets. In the present case the method developed based on absorbance ratio method (Q method). Absorbance ratio method uses the ratio of abs

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2

Atole, Dipali M., and Hrishikesh H. Rajput. "ULTRAVIOLET SPECTROSCOPY AND ITS PHARMACEUTICAL APPLICATIONS- A BRIEF REVIEW." Asian Journal of Pharmaceutical and Clinical Research 11, no. 2 (2018): 59. http://dx.doi.org/10.22159/ajpcr.2018.v11i2.21361.

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Rapid and easy analytical methods are needed due to increasing number of multicomponent formulations, biotherapeutic products and samples of complex matrix in que. Number of Ultraviolet (UV) spectrophotometric methods used for these purpose. Different types of UV spectrometric methods developed on the basis of principle of additivity, absorbance difference, processing absorption spectra. The aim of this review is to present information on simultaneous equation method, difference spectrophotometry, derivative spectrophotometry, absorbance ratio spectra, derivative ratio spectra, successive rati

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3

Kuntala, Sri Vidya, Priyanka Amula, Priyanka Adepu, Varshini Boini, and A. Ravi kiran. "Simultaneous Estimation of Luliconozole and Methyl Paraben in Pharmaceutical Formulation by UV Spectroscopy using Absorption Ratio Method." YMER Digital 21, no. 07 (2022): 69–83. http://dx.doi.org/10.37896/ymer21.07/05.

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For the simultaneous quantification of luliconazole (LUZU) and methyl paraben (MP) in formulation, a straightforward, precise UV spectrophotometric approach was developed and validated. The method was developed using absorbance ratio method. For luliconazole and methyl paraben, the absorbance was measured at 297 nm and 274 nm, respectively. The method was discovered to be linear, sensitive, exact and accurate. ICH guidelines were followed in developing the procedure. Keywords: Q- absorbance ratio method, methyl paraben, luliconazole, and UV spectrophotometric method.

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4

Preeti, Sudhir Bobade, and Baburaoji Ganorkar Saurabh. "Establishing Pharmaceutical Brand Variability for Bisoprolol Fumarate and Hydrochlorothiazide Combinations: As an applied Q-absorbance Spectrophotometry." Pharmaceutical Methods 8, no. 1 (2017): 01–05. https://doi.org/10.5281/zenodo.14854486.

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The amalgamation of a unique spectrophotometric technique and principle concept of studying variations in pharmaceutical brands as a contrivance for simultaneous determination of the highly marketed combination of Bisoprolol fumarate and Hydrochlorothiazide  is established  hereby. The commercial purpose of marketing same drugs or drug combinations by different names creates scope for such analysis. Hence an accurate, precise and sensitive Q-Absorbance ratio UV-spectrophotometric method has been developed  and validated for the  simultaneous estimation o

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5

Sai, Krishna Guduru Praveen Kumar Dasari. "Method Development, Validation And Stability Indicating Studies Of Olmesartan Medoxomil In Bulk And Pharmaceutical Dosage Form By UV-Spectroscopy." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 611–16. https://doi.org/10.5281/zenodo.10968588.

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Development of UV spectrophotometric method for the estimation of Olmesartan medoxomil was done by Q-Absorbance ratio method and area under curve method and stability indicating studies using methanol as solvent. In the present research, we have made an attempt to develop a simple, specific, accurate, precise and reproducible method for the estimation of Olmesartan medoxomil in dosage form by UV spectrophotometric method. The method includes area under curve method (Method I) and Q- absorbance Ratio method (Method II). The wavelength is 243 nm of the drug were selected for Method I, and for Q-

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6

Naimuddin, Riyazuddin Saiyed, C. Jain Vineet, Dedania Zarana, K. Patel Harshad, and C. Patel Rajendrakumar. "Development and validation of UV spectroscopic Q-absorbance ratio method for zonisamide and aripirazole in synthetic mixture." World Journal of Biology Pharmacy and Health Sciences 13, no. 2 (2023): 266–76. https://doi.org/10.5281/zenodo.8026889.

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A simple, specific, accurate and precise Q-Absorbance ration spectrophotometric method was developed and validated for estimation of Zonisamide and Aripirazole in Synthetic Mixture. Zonisamide and Aripirazole showed and iso-absorptive point at 230.50nm in Distilled water. The second wavelength used was 240.60nm which is λmax of Aripirazole in distilled water. The concentration of the drugs was determined by using ratio of absorbance at iso-absorptive point (λ1 =240.60 nm) and at the λmax of Aripirazole (λ2 =230.50 nm). This method is linear for both drugs; in range

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7

Patil, Pooja A., Hasumati A. Raj, and Gautam B. Sonara. "Q-ABSORBANCE RATIO SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF ATENOLOL AND IVABRADINE HYDROCHLORIDE IN SYNTHETIC MIXTURE." Pharmaceutical and Biological Evaluations 3, no. 2 (2016): 224–30. https://doi.org/10.5281/zenodo.51066.

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Objective: It describes Simultaneous estimation of simple, accurate, precise, robust and economical Q-Absorbance ratio spectrophotometric method for Atenolol and Ivabradine HCl in synthetic mixture. Objective of the study was to deliver information related to Ivabradine HCl and Atenolol combination’s analytical method. Methods: Absorbance ratio method for the ratio of absorbance at two selected wavelengths, one which is an iso-absorbtive point and other being the λ-max of one of the two components. Atenolol and Ivabradine HCl showed an iso-absorbtive point at 286.40 nm in methanol

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8

Jhanwar, Bharat, Bhupendra Singh, Geetanjali Saini, and Surajpal Verma. "METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF LEVOSULPIRIDE AND RABEPRAZOLE SODIUM: A NEW ANALYTICAL Q-ABSORBANCE RATIO APPROACH." Asian Journal of Pharmaceutical and Clinical Research 10, no. 16 (2017): 22. http://dx.doi.org/10.22159/ajpcr.2017.v10s4.21331.

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Objective: The aim of the study was to develop a precise, accurate, and rapid ultraviolet spectrophotometric method for simultaneous estimation of levosulpiride (LEVO) and rabeprazole sodium (RBS) in the binary mixture and to validate the method as per ICH guidelines.Method: Estimation of LEVO and RBS was performed by Q-absorbance method. Analysis was performed using the ratio of absorbance at two selected wavelengths, one at iso-absorptive point and other is the absorbance maxima of any one of the components. Single scan spectrum and the overlain spectrum conclude that absorbance maxima of LE

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9

D.NAGAVALLI and R.SHANMUGAVEL. "Simultaneous Equation, Absorbance Ratio and First Order Derivative Methods for the Estimation of Atorvastatin Calcium and Fenofibrate in Solid Dosage Form." International Journal of Innovative Science and Research Technology 8, no. 2 (2023): 457–61. https://doi.org/10.5281/zenodo.7659258.

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Three simple, precise, accurate, specific and reproducible spectrophotometric methods, requiring no prior separation, have been developed for the simultaneous estimation of atrovastatin calcium (ATV) and fenofibrate (FEN) in combined dosage form. Quantitative estimation of these drugs in marketed brands of the tablet was carried out using simultaneous equation, absorbance ratio and first order derivative methods. In the simultaneous equation method ATV and FEN have absorbance maxima at 247 and 289 nm respectively in methanol. Second method employs Q absorbance analysis using 254 nm (Isobestic

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Ee How, Gan, and Venkata Subrahmanya Lokesh Bontha. "SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF DAPAGLIFLOZIN AND SAXAGLIPTIN IN FIXED DOSE COMBINATION (FDC) BY Q-ABSORBANCE RATIO METHOD." INDIAN DRUGS 57, no. 11 (2021): 63–75. http://dx.doi.org/10.53879/id.57.11.12657.

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A simple Q-absorbance ratio method have been developed for the determination of dapagliflozin (DAPA) and saxagliptin (SAXA) in fixed dose combination (FDC) using UV-Visible spectrophotometer. In this method, the UV spectra of DAPA and SAXA were overlaid to obtain wavelength at isosbestic point (λiso) of 217.6 nm and at absorption maximum (λmax) of DAPA at 224.2 nm, which are involved in the formation of Q-absorbance equation. Validation of method was done according to ICH guidelines. DAPA and SAXA obeyed Beers law in the concentration range of 2-25 µg/mL and 5-25 µg/mL, respectively. Good accu

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11

Devang, Tandel* Kalpana Patel Margi Patel Vaishali Thakkar Tejal Gandhi. "Ecofriendly Q-Absorbance Ratio Spectrophotometric Method for Simultaneous Quantification of Rifampicin and Quercetin in Liquisolid Dosage Form." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1443–57. https://doi.org/10.5281/zenodo.15034396.

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A sensitive, quick, precise, accurate, robust, and ecofriendly Q- absorption ratio spectrophotometric technique was developed and validated for estimation of Rifampicin and Quercetin in two dissolution media pH - 6.8 phosphate buffer and 0.1 M Hydrochloric acid and successfully applied for estimation of liquisolid formulation. Rifampicin and Quercetin showed an iso-absorptive point at 420 and 411 nm in pH - 6.8 phosphate buffer and 0.1 M Hydrochloric acid respectively. The second wavelength used was 368 and 367 nm which is λmax of Quercetin in pH - 6.8 phosphate buffer and 0.1 M Hydroch

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12

Jadhav, Monika L., Manoj V. Girase, Shripad K. Tidme, and Manish S. Junagade. "Development and Validation of Spectrophotometric Methods for Simultaneous Estimation of Valsartan and Hydrochlorothiazide in Tablet Dosage Form." International Journal of Spectroscopy 2014 (January 9, 2014): 1–6. http://dx.doi.org/10.1155/2014/873819.

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Two UV-spectrophotometric methods have been developed and validated for simultaneous estimation of valsartan and hydrochlorothiazide in a tablet dosage form. The first method employed solving of simultaneous equations based on the measurement of absorbance at two wavelengths, 249.4 nm and 272.6 nm, λmax for valsartan and hydrochlorothiazide, respectively. The second method was absorbance ratio method, which involves formation of Q-absorbance equation at 258.4 nm (isoabsorptive point) and also at 272.6 nm (λmax of hydrochlorothiazide). The methods were found to be linear between the range of 5–

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13

Arpitha, G., D. B. Shubha, H. B. Chinthana, and S. Brunda. "Simultaneous determination and validation of Aceclofenac and cyclobenzaprine hydrochloride by area under curve and q-absorbance ratio methods in bulk and pharmaceutical formulations." World Journal of Biology Pharmacy and Health Sciences 17, no. 1 (2024): 006–13. https://doi.org/10.5281/zenodo.11244404.

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A simple, accurate, rapid and UV spectrophotometric methods has been developed for the simultaneous estimation of Aceclofenac (ACF) and Cyclobenzaprine hydrochloride (CBP) in bulk and combined tablet dosage form. The methods employed were(A) Area under curve and (B) Q-absorbance ratio method. Method- A involves measurement of peak area in the wavelength range 271-281 nm and 220-230 nm for ACF and CBP respectively. In Method B two wavelengths 276 nm, λ max of Aceclofenac and 257 nm, the isobestic point were selected. In both the methods linearity was found in the concentration range of 6

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14

Bhusari, Sachin, Bharti Gotmare, and Pravin Wakte. "SIMULTANEOUS ESTIMATION OF DOXORUBICIN AND HYDROXYCHAVICOL IN BULK AND PHARMACEUTICAL FORMULATION BY Q-ABSORPTION RATIO METHOD." INDIAN DRUGS 57, no. 02 (2020): 51–58. http://dx.doi.org/10.53879/id.57.02.11873.

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A simple, rapid, accurate, precise and economical UV-spectrophotometric method has been developed and validated for simultaneous estimation of doxorubicin hydroxychavicol (DOXO) and OH-CHV in a pharmaceutical formulation. It is based on the Q-analysis UV Spectrophotometric method. The absorption spectra of DOXO and OH-CHV were obtained over the range of 200-800 nm, and the absorption maxima were determined. Multiple calibration standards were prepared for both the drugs separately and absorbances were recorded at respective absorption maxima. Calibration curves were plotted and the linear resp

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15

Patil, Pooja A., Hasumati A. Raj, and Gautam B. Sonara. "Q-Absorbance Ratio Spectrophotometric method for simultaneous determination of Atenolol and Ivabradine HCl in synthetic mixture." Asian Journal of Research in Pharmaceutical Science 6, no. 1 (2016): 27. http://dx.doi.org/10.5958/2231-5659.2016.00004.7.

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16

Naimuddin Riyazuddin Saiyed, Vineet C Jain, Zarana Dedania, Harshad K Patel, and Rajendrakumar C. Patel. "Development and validation of UV spectroscopic Q-absorbance ratio method for zonisamide and aripirazole in synthetic mixture." World Journal of Biology Pharmacy and Health Sciences 13, no. 2 (2023): 266–76. http://dx.doi.org/10.30574/wjbphs.2023.13.2.0043.

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A simple, specific, accurate and precise Q-Absorbance ration spectrophotometric method was developed and validated for estimation of Zonisamide and Aripirazole in Synthetic Mixture. Zonisamide and Aripirazole showed and iso-absorptive point at 230.50nm in Distilled water. The second wavelength used was 240.60nm which is λmax of Aripirazole in distilled water. The concentration of the drugs was determined by using ratio of absorbance at iso-absorptive point (λ1 =240.60 nm) and at the λmax of Aripirazole (λ2 =230.50 nm). This method is linear for both drugs; in range 10-30 μg/ml at λ1 R2 = 0.996

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17

Ali, Diyar Salahuddin. "Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations." Journal of Analytical Methods in Chemistry 2023 (January 17, 2023): 1–14. http://dx.doi.org/10.1155/2023/5107317.

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Simple, accurate, precise, and cost-effective chemometric techniques for the measurement of candesartan cilexetil and hydrochlorothiazide in synthetic mixtures were improved and validated. H-point standard addition, Q-absorption ratio, and correction absorbance spectrophotometric techniques were utilized for the simultaneous determination of both medicines in real pharmaceutical formulations. A new calibration approach was implemented based on chemical H-point standards. This approach was developed to resolve significantly overlapping spectra of two analytes and provide direct correction of bo

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18

Rahul, Rajan R. S.1* Anitha Thomas2. "Simultaneous Estimation Of Rosuvastatin Calcium And Ezetimibe In Their Combined Tablet Dosage Form By Absorbance Ratio Method." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 180–86. https://doi.org/10.5281/zenodo.13646983.

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A simple, accurate, precise, and economical Q-absorbance ratio UV-spectrophotometric method was developed and validated for simultaneous estimating Rosuvastatin Calcium and Ezetimibe in combined tablet dosage form. The solvent used was a 1:1 t mixture of Isopropyl alcohol and distilled water. Two wavelengths 244nm (λmax of Rosuvastatin Calcium) and 240nm (Isoabsorptive point) were selected to estimate Rosuvastatin Calcium and Ezetimibe for the Q-Absorbance ratio method. The drug concentration was determined using the ratio of absorbance at the iso-absorptive point (λ1 = 240 nm) a

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19

Pandey, Gitu, and Brahmeshwar Mishra. "A New Analytical Q-Absorbance Ratio Method Development and Validation for Simultaneous Estimation of Lamivudine and Isoniazid." ISRN Spectroscopy 2013 (December 16, 2013): 1–5. http://dx.doi.org/10.1155/2013/912376.

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A new UV spectrophotometric absorption ratio method was developed and validated for the simultaneous estimation of lamivudine and isoniazid. The method involved Q-absorption ratio analysis using two wavelengths, with one being the λmax of lamivudine (272 nm, λ2) and the other being the isoabsorptive point of both drugs (246 nm, λ1). Beer’s law was obeyed in the concentration range between 5 and 30 µg/mL for both lamivudine and isoniazid. The results of analysis have been validated statistically and by recovery studies as per ICH guidelines. The accuracy ranged between 99.65 and 101.91% and San

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20

Bhavyasri, Dr Khagga, Samreen Begum, D. Suchitra, V. Narmada, and Dr Mogilli Sumakanth. "Estimation of Repaglinide and Metformin HCls from Pharmaceutical Formulation by Q-Absorbance Ratio Method Using UV Spectrophotometer." International Journal of Pharma and Bio Sciences 15, no. 1 (2024): 64–72. http://dx.doi.org/10.22376/ijpbs.2024.15.1.p64-72.

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Utkoor, Umesh Kumar, Prashanthi Malyala, Yaku Gugulothu, and Chandra Rekha Kasigari. "VALIDATED UV- SPECTROPHOTOMETRIC METHODS FOR THE SIMULTANEOUS ESTIMATION OF DEXTROMETHORPHAN AND CETRIZINE." Journal of Advanced Scientific Research 13, no. 03 (2022): 133–40. http://dx.doi.org/10.55218/jasr.202213321.

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Using UV Spectrophotometric methods, a simple, precise and accurate approach is devised and verified for the simultaneous assessment of Dextromethorphan (DEX) and Cetrizine (CET) in combined dosage form. The approach 1 is the Dual wavelength method, which was developed, evaluates the difference in the absorbance of mixtures at wavelengths where single drugs have the same absorbance and vice versa. Approach 2 is a mean-centered ratio method that relies on the production of calibration by dividing the spectra of one substance by the spectra of the other. Approach 3 is a derivative spectrum metho

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22

Patel, Ushma B., and Paresh U. Patel. "DEVELOPMENT AND VALIDATION OF Q-ABSORBANCE RATIO METHOD FOR SIMULTANEOUS DETERMINATION OF ROFLUMILAST AND SALMETEROL IN SYNTHETIC MIXTURE." International Research Journal of Pharmacy 7, no. 1 (2016): 58–61. http://dx.doi.org/10.7897/2230-8407.07110.

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23

Patel, Chiragkumar B., and Satish A. Patel. "DEVELOPMENT AND VALIDATION OF Q-ABSORBANCE RATIO METHOD FOR SIMULTANEOUS ESTIMATION OF VALSARTAN AND NIFEDIPINE IN SYNTHETIC MIXTURE." International Research Journal of Pharmacy 7, no. 1 (2016): 62–65. http://dx.doi.org/10.7897/2230-8407.07111.

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24

Mashru, Rajashree, and Nirupa Koshti. "Development and validation of UV-Spectrophotometric and RP-HPLC method for simultaneous estimation of Metformin and Doxycycline in bulk and synthetic mixture." Journal of Drug Delivery and Therapeutics 11, no. 4-S (2021): 26–35. http://dx.doi.org/10.22270/jddt.v11i4-s.4964.

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A simple, rapid, sensitive, accurate and precise UV spectrophotometric and isocratic RP-HPLC method have been developed for simultaneous estimation of Metformin and Doxycycline in bulk and synthetic mixture. Spectrophotometric estimation was done by two methods. First method was Q-absorbance ratio method, where two wavelengths 236 nm (λmax of Metformin) and 248 nm (Iso-absorptive point) were used. The second method was first derivative method. In this method the zero-crossing point of Metformin was selected at 282 nm and for Doxycycline, it was 232 nm. The solvent used was methanol in both the

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Lotfy, Hayam Mahmoud, Yasmin Mohamed Fayez, Adel Magdy Michael, and Christine Kamal Nessim. "Evaluation of the Efficiency of Smart Stability-Indicating Spectrophotometric Methods Based on Mathematical and Statistical Processing of the Obtained Results Via Different Manipulating Pathways." Current Pharmaceutical Analysis 16, no. 2 (2020): 186–200. http://dx.doi.org/10.2174/1573412914666181017144323.

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Background: Smart different stability-indicating spectrophotometric methods have been established for the assay of chlordiazepoxide and clidinium bromide without the intervention of alkaline degradate of clidinium via various and different manipulating pathways without previous separation steps. Objective: The specificity of the established methods was inspected by analysing mixtures of cited drugs in the existence of the alkali-induced degradation product. Methods: These methods were employed either on scanned zero-order absorption spectra using absorbance subtraction, dual wavelength and Q-a

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Vishal, Sambhaji Sutar1* Nitin Anandrao Kamble2. "Phytochemical Screening And Gc-Ms Analysis Of Ocimum Sanctum, Amaranthus Viridis, And Cystone." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 258–70. https://doi.org/10.5281/zenodo.13694788.

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A simple, accurate, precise, and economical Q-absorbance ratio UV-spectrophotometric method was developed and validated for simultaneous estimating Rosuvastatin Calcium and Ezetimibe in combined tablet dosage form. The solvent used was a 1:1 t mixture of Isopropyl alcohol and distilled water. Two wavelengths 244nm (λmax of Rosuvastatin Calcium) and 240nm (Isoabsorptive point) were selected to estimate Rosuvastatin Calcium and Ezetimibe for the Q-Absorbance ratio method. The drug concentration was determined using the ratio of absorbance at the iso-absorptive point (λ1 = 240 nm) a

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27

Jain, Mayur S., Sunil R. Bavaskar, Shashikant D. Barhate, and Jintendra D. Fegade. "SIMULTANEOUS UV SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF CEFADROXIL AND PROBENECID IN TABLET DOSAGE FORM." International Journal of Drug Regulatory Affairs 1, no. 3 (2018): 19–23. http://dx.doi.org/10.22270/ijdra.v1i3.116.

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Two methods for simultaneous estimation of Cefadroxil and Probenecid in combined tablet dosage form have been developed. The first UV spectrophotometric method was a determination using the simultaneous equation method at 233 nm and 247 nm. The second UV spectrophotometric method is the Q – analysis (absorption ratio) method, which involves the formation of absorbance equation at 242 nm (Isobestic point) and at 247 nm the maximum absorption of Probenecid . The linearity ranges for Cefadroxil and Probenecid both were 10-60μg/ml respectively. The accuracy of the methods was assessed by recovery

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Rana, onika A., and Hasumati A. Raj. "Q Absorbance Ratio Method of Levosulpiride and 2-Methoxy 5-Sulfamoylbenzoyl Benzoic Acid Methyl Ester in Their Synthetic Mixture." Asian Journal of Pharmaceutical Analysis 5, no. 2 (2015): 67. http://dx.doi.org/10.5958/2231-5675.2015.00011.3.

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Kajal, Kumrawat, and Tiwari Archana. "Simultaneous Estimation of Sacubitril and Valsartan Combination of Drug in Tablet Dosage Form Using Hydrotropy by UV Spectrophotometry." International Journal of Pharmaceutical Sciences and Medicine 7, no. 1 (2022): 1–23. http://dx.doi.org/10.47760/ijpsm.2022.v07i01.001.

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Sacubitril/valsartan, traded under the brand name Entresto between others, is a fixed-dose combination medication for use heart failure. Sacubitril is a neprilysin inhibitor (A prodrug) and is used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure. It is anti - hypertensive drug. Valsartan is an Angiotensin Receptor Blocker (ARB) that may be used to treat a variety of cardiac conditions including hypertension, diabetic nephropathy and heart failure. Two UV-spectrophotometric methods have been developed and validated for simultaneou

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Swetha, Yarramsetti, Elphine Prabahar A., and Rao Nadendla Rama. "Multiple Method Development and Validation for Simultaneous Estimation of Chlorzoxazone and Nimesulide in Bulk and Pharmaceutical Dosage Form." International Journal of Trend in Scientific Research and Development 3, no. 2 (2019): 944–48. https://doi.org/10.31142/ijtsrd21503.

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A simple, precise and accurate multiple analytical method has been developed for the simultaneous estimation of Chlorzoxazone and Nimesulide in bulk and tablet formulations by reversed phase liquid chromatographic and UV Visible spectrophotometric techniques. The chromatographic separation was achieved on C18 analytical column. A mixture of Methanol 0.1 Ortho phosphoric acid 75 25 was used as mobile phase, at a flow rate of 1mL min and detection wavelength at 295 nm. The retention time of Chlorzoxazone and Nimesulide was found to be 4.69 and 5.45 min respectively. The linear dynamic ranges for

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Attia, Khalid A. M., Nasr M. A. El-Abassawi, Ragab A. M. Said, Ahmed El-Olemy, and Sherif Ramzy. "Comparative Study Between Zero-Order Spectra-Processing and Ratio Spectra-Manipulating Methods Applied for the Determination of Isoxsuprine Hydrochloride in the Presence of Its Oxidative Degradation Product." Journal of AOAC INTERNATIONAL 100, no. 6 (2017): 1739–46. http://dx.doi.org/10.5740/jaoacint.16-0296.

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Abstract Four accurate, precise, and validated stability-indicating spectrophotometric methods handling either zero-order spectra or ratio spectra have been developed and compared for the analysis of isoxsuprine hydrochloride (ISX) in the presence of its oxidative degradation product. The first two methods processed zero-order spectra, namely graphical absorbance ratio or Q-Analysis and area under the curve, whereas the third and fourth methods manipulated ratio spectra, namely the ratio difference spectrophotometric method and derivative ratio. The proposed methods showed good linearity in th

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Arpitha G, Shubha D B, Chinthana H B, and Brunda S. "Simultaneous determination and validation of Aceclofenac and cyclobenzaprine hydrochloride by area under curve and q-absorbance ratio methods in bulk and pharmaceutical formulations." World Journal of Biology Pharmacy and Health Sciences 17, no. 1 (2024): 006–13. http://dx.doi.org/10.30574/wjbphs.2024.17.1.0502.

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A simple, accurate, rapid and UV spectrophotometric methods has been developed for the simultaneous estimation of Aceclofenac (ACF) and Cyclobenzaprine hydrochloride (CBP) in bulk and combined tablet dosage form. The methods employed were(A) Area under curve and (B) Q-absorbance ratio method. Method- A involves measurement of peak area in the wavelength range 271-281 nm and 220-230 nm for ACF and CBP respectively. In Method B two wavelengths 276 nm, λ max of Aceclofenac and 257 nm, the isobestic point were selected. In both the methods linearity was found in the concentration range of 6-30 µg/

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Shivani, Herma* Kiran Rathod Dr. Chintankumar Tank Denisha Meghnathi Himanshu Parmar Pritesh Odedara. "Unraveling Complexity: A Critical Review of UV Spectrophotometric Methods for Multicomponent Analysis." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 588–602. https://doi.org/10.5281/zenodo.15591790.

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Spectroscopy is a scientific method that analyses the interaction of matter with light or electromagnetic radiation. It can be divided into atomic, molecular, absorption, and electronic levels, with UV spectroscopy being the most widely used for analysing various compounds. UV spectrophotometric methods use the principle of additivity and absorbance to record and mathematically process absorption spectra of standard solutions and sample solutions. This process leads to electron excitation, causing transitions between energy levels. Multicomponent analysis is a growing challenge in modern chemi

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Sharma, Pushpendra, Srinivasarao Kosanam, and Surendra Singh Rao. "Development and Validation of Q-Absorbance Ratio by UV-Spectrophotometric Method for Simultaneous Estimation of Metformin and Empagliflozin in Bulk and Combined Dosage Form." Journal of Drug Delivery and Therapeutics 11, no. 2-S (2021): 14–18. http://dx.doi.org/10.22270/jddt.v11i2-s.4624.

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Advantages of simultaneous stability studies are the identification of new degradation products, to understand mutual induction and/or inhibition of rates of degradation and to analyze the degradation products of both drugs. Various ultraviolet spectroscopic and high performance liquid chromatographic assay methods were reported for the estimation of metformin, sitagliptin, pioglitazone, glimepiride and simvastatin individually and in combination with other drugs. All the above reported methods were based on the estimation of metformin, sitagliptin, pioglitazone, glimepiride and simvastatin al

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Gadge, Sonali S., Ashish D. Nakod, Vaishali P. Wasnik, et al. "Development and Validation of Q-absorbance Ratio method for Simultaneous Estimation of Teniligliptin hydrobromide and Metformin HCl in Multicomponent Dosage Form." Asian Journal of Pharmaceutical Analysis 9, no. 4 (2019): 215. http://dx.doi.org/10.5958/2231-5675.2019.00036.x.

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Deshmukh, Madhuri, Sachin Bhusari, and Pravin Wakte. "Development and Validation of Q-Absorbance Ratio Spectrophotometric Method for the Simultaneous Estimation of Ciprofloxacin and Ornidazole; in Combined Pharmaceutical Dosage." Journal of Drug Delivery and Biotherapeutics 1, no. 2 (2023): 1–15. http://dx.doi.org/10.61920/jddb.v1i02.32.

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Thakur, Bhumika, Shiv Kumar Kushawaha, Vinay Pandit, Mahendra Singh Ashawat, and Pravin Kumar. "Formulation and Evaluation of Fixed Dose Combination Tablets of Antifungal Drugs for Candida albicans Resistant to Fluconazole." Journal of Drug Delivery and Therapeutics 10, no. 2 (2020): 26–36. http://dx.doi.org/10.22270/jddt.v10i2.3905.

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Background: The emergence of Candida albicans strains resistant to fluconazole (FLZ) had raised interest on combining other antifungals with FLZ. In vitro and clinical studies had indicated synergistic interaction between terbinafine and FLZ against strains resistant to FLZ and improved therapeutic efficacy. Objective: Formulation and evaluation of fixed dose combination (FDC) tablets of terbinafine HCl (TH) and FLZ for avoidance of resistance and improved therapeutic efficacy against C. albicans infections. Method: The compatibility of TH and FLZ together and with excipients was determined by

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SHIROLE, Prathamesh, Dhanashree SANAP, and Kisan JADHAV. "Development and validation of Q-absorbance ratio spectrophotometric method for simultaneous estimation of ondansetron HCl and esomeprazole magnesium in bulk and formulation." Journal of Research in Pharmacy 27(6), no. 27(6) (2023): 2522–29. http://dx.doi.org/10.29228/jrp.545.

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Simoes, M., and L. Almeida. "DEVELOPMENT AND VALIDATION OF A UV SPECTROPHOTOMETRIC Q-ABSORBANCE RATIO METHOD FOR SIMULTANEOUS ESTIMATION OF EPERISONE HYDROCHLORIDE AND ACECLOFENAC IN BULK AND TABLET DOSAGE FORM." INDIAN DRUGS 55, no. 11 (2018): 50–56. http://dx.doi.org/10.53879/id.55.11.11327.

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A simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method has been developed for the simultaneous estimation of eperisone hydrochloride and aceclofenac in combined dosage form. The solvent used was methanol:water (70:30 v/v). The iso-absorptive point was found to be 269.5 nm. Calibration curves were linear over a concentration range of 6-21 μg/ml for eperisone hydrochloride and 8-28 μg/mL for aceclofenac, respectively. The developed method was validated as per International Conference on Harmonization (ICH) guidelines for various parameters such as linearity, preci

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Fasurová, N., and L. Pospíšilová. "Spectroscopic characteristics of humates isolated from different soils." Soil and Water Research 6, No. 3 (2011): 147–52. http://dx.doi.org/10.17221/21/2010-swr.

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&nbsp; Spectral characterisation of soil humic substances is one of the important methods for their quality identification. In this work, two optical methods (UV-VIS and SFS) were used. The absorbance in the spectral range of 300&ndash;700 nm was measured using spectrometer Varian Cary 50 Probe. Fluorescence (SFS) in the range of 255&ndash;655&nbsp;nm was performed by spectrofluorimeter Aminco Bowman. Five Czech soil humates samples (Leptic Cambisol, Haplic Cambisol, Eutric Cambisol 1-arable soil, Eutric Cambisol 2-grassland, Haplic Chernozem) were compared. The basic soil prop

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Bhusari, Sachin Shivling, Shreya Hiralal Waghmare, and Pravin Shridhar Wakte. "DEVELOPMENT AND VALIDATION OF Q-ABSORBANCE RATIO SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF RIFAMPICIN AND ITS BIOENHANCER; 3, 5'-DIHYDROXYFLAVONE-7-O-B-D-GALACTURONIDE-4'-O-B-D-GLUCOPYRANOSIDE; IN BULK AND FORMULATION." Journal of Pharmaceutical & Scientific Innovation 8, no. 5 (2019): 182–88. http://dx.doi.org/10.7897/2277-4572.085152.

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Li, Jiancheng, and Weijie Sun. "PS02.060: EXPLORATION OF RADIOSENSITIVITY-RELATED LNCRNA IN ESOPHAGEAL CANCER STEM CELL." Diseases of the Esophagus 31, Supplement_1 (2018): 137–38. http://dx.doi.org/10.1093/dote/doy089.ps02.060.

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Abstract Background Esophageal cancer stem cells are the most radiation-resistant cells, to study radiosensitivity with esophageal cancer stem cells is a better method, Previously study was only the relevant microRNA research, so we explore radiosensitivity-related LncRNA in esophageal cancer stem cell. Methods The Eca109 cells were divided into tumor sphere cells group and adherent cells group by using suspended and adherent culture. Differences in stem cell characteristics of two groups were compared by CD44 positive expression rate, CCK8 cell proliferation and plate cloning formation. Using

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Faizan, Sayeed*. "FORMULATION AND EVALUATION OF TIME DEPENDENDT RELEASE OF MONTELUKAST TABLETS BY USING MINI TABLET TECHNOLOGY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2550–62. https://doi.org/10.5281/zenodo.1219739.

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Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma, chronic asthma attacks and to relive symptoms of seasonal allergies. The main drawback of conventional Montelukast formulation is that it undergoes hepatic first pass metabolism. Thus, it shows plasma or biological half-life 2.5 to 5.5 hrs, thereby decreasing bioavailability upto 64%. The present work describes such delivery system, which will improve the biological half-life as well as bioavailability of Montelukast. This makes Montelukast a suitable candidate for incorporation in sustained-r

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Paul, K. John, Jeeno Jose, A. R. Shivashankara, Cleeta Rebeiro, and Dania P. Johnson. "Evaluating the thrombolytic property of Juniperus Sabina tincture using spectrophotometry." Journal of Integrated Standardized Homoeopathy 6 (September 9, 2023): 31–38. http://dx.doi.org/10.25259/jish_20_2023.

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Objectives: We aimed to explore the thrombolytic property of Juniperus Sabina by measuring the absorbance level of released haemoglobin (Hb) during clot lysis. Materials and Methods: Approximately 0.3 mL of blood was added to four 15 mL centrifuge tubes and blood clots were allowed to form naturally. The clots were incubated for 45 min and washed with normal saline. Using a visible spectrophotometer, the absorbance of Hb was recorded at five wavelengths: 405, 416, 541, 576 and 580 nm. Lyophilised recombinant streptokinase (SK) was used as standard control. J. Sabina mother tincture (83.28% v/v

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Ashritha, V. V. S., N. Usharani, Soudamini Alekhacharan, B. Alekhya, and R. Venkatesh. "Development of Validated Q-absorbance Ratio, Derivative Spectrophotometric and Stability indicating RP-HPLC methods for the simultaneous estimation of Losartan Potassium & Hydrochlorothiazide in Pharmaceutical Dosage Form and comparison of the results by ANOVA." Research Journal of Pharmacy and Technology 12, no. 6 (2019): 2687. http://dx.doi.org/10.5958/0974-360x.2019.00449.9.

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Fernandes, Samantha, Celina Nazareth, and Bhakti Naik. "Simultaneous Analysis of Cilnidipine and Nebivolol by Absorbance Correction Method and Q Absorption Ratio Method." Research Journal of Pharmacy and Technology, July 24, 2023, 3213–18. http://dx.doi.org/10.52711/0974-360x.2023.00528.

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Two novel UV spectrophotometric methods have been developed for the simultaneous estimation of cilnidipine (CIL) and nebivolol hydrochloride (NBV) in combined dosage form. Method I was based on absorbance correction principle while method II was Q absorption ratio method. For absorbance correction method, λmax of CIL 242.6nm was chosen as λ1, as NBV shows nil absorbance at this wavelength and 280.6nm, the λmaxof NBV was chosen as λ2 , as both the drugs showed satisfactory absorbance at this wavelength. Beer’s law was obeyed in the concentration range of 4-48μg/mL and 4-100μg/mL for cilnidipine

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PROMA MUKHERJEE, DEBARUPA DUTTA CHAKRABORTY, PRITHVIRAJ CHAKRABORTY, BHUPENDRA SHRESTHA, and NIHAR RANJAN BHUYAN. "DIFFERENT ULTRAVIOLET SPECTROSCOPIC METHODS: A RETROSPECTIVE STUDY ON ITS APPLICATION FROM THE VIEWPOINT OF ANALYTICAL CHEMISTRY." Asian Journal of Pharmaceutical and Clinical Research, September 7, 2021, 1–11. http://dx.doi.org/10.22159/ajpcr.2021.v14i9.42172.

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In routine practice, some simple and rapid analytical methods are needed for the assessment of formulations containing multiple elements, complex matrix system and for biotherapeutic products. There are several methods available for ultraviolet (UV) spectrophotometry that rely on the concept of absorbance difference, absorbance spectra, and additivity, also included in the list are simultaneous equation method, Q-absorbance ratio method, derivative spectrophotometry, ratio derivative spectra, successive ratio-derivative spectra, absorption and absorptivity factor method, and difference spectro

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Sawant, Ramesh L. Bharat Anjali V.* Tanpure Kallyani D. and Jadhav Kalyani A. "Spectroscopic methods for the simultaneous estimation of theophylline and furosemide." March 13, 2023. https://doi.org/10.5281/zenodo.7729095.

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The simple, sensitive and specific U.V. spectrophotometric methods were developed for simultaneous determination of theophylline (THE) and furosemide (FUR) in synthetic mixture. Spectrophotometric studies were carried out using double beam JASCO U.V. spectrophotometer with methanol as solvent. The present work includes two methods: method A- simultaneous equation method and method B-absorbance ratio method. Wavelength selected are 272 nm for THE and 275 nm for FUR respectively. In both the methods linearity were observed in the concentration range of 5-30 µg/ml and 5-35 µg/ml for T

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Sawant, Ramesh L. Bharat Anjali V.* Tanpure Kallyani D. and Jadhav Kallyani A. "Spectroscopic methods for the simultaneous estimation of theophylline and furosemide." March 14, 2023. https://doi.org/10.5281/zenodo.7731967.

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The simple, sensitive and specific U.V. spectrophotometric methods were developed for simultaneous determination of theophylline (THE) and furosemide (FUR) in synthetic mixture. Spectrophotometric studies were carried out using double beam JASCO U.V. spectrophotometer with methanol as solvent. The present work includes two methods: method A- simultaneous equation method and method B-absorbance ratio method. Wavelength selected are 272 nm for THE and 275 nm for FUR respectively. In both the methods linearity were observed in the concentration range of 5-30 µg/ml and 5-35 µg/ml for T

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S, Prasanth S., Anjitha A. A, Athulya K. K, Anziya P R, and Anziya P. R. "Q-ABSORBANCE RATIO AND VIERODT’S SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF FAMOTIDINE AND OMEPRAZOLE." International Journal of Pharmaceutics and Drug Analysis, April 4, 2023, 9–16. http://dx.doi.org/10.47957/ijpda.v11i1.529.

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Famotidine and omeprazole are the drugs used in the treatment of gastrointestinal disorders. The current work is an analytical method for the simultaneous determination of famotidine and omeprazole and is based on the Q-absorption method and Vierodt’s method. These two methods depend on the isosbestic point and the ?max of one of the two components. The isosbestic point was found to be 295 nm in ethanol. 287nm and 301nm are the ?max of famotidine and omeprazole respectively. The method is validated as per ICH guidelines.

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