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Journal articles on the topic 'Q Science (General) ; QH301 Biology'

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Published: 4 June 2021
Last updated: 6 February 2022

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1

Hardway, Glenn A. "“Q” SWITCHING." Annals of the New York Academy of Sciences 122, no. 2 (December 16, 2006): 608–13. http://dx.doi.org/10.1111/j.1749-6632.1965.tb20241.x.

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2

Crane, F. L. "New functions for coenzyme Q." Protoplasma 213, no. 3-4 (September 2000): 127–33. http://dx.doi.org/10.1007/bf01282150.

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3

Kell, Professor Douglas, and Richard Reece. "Q&A." Biochemist 30, no. 6 (December 1, 2008): 31–32. http://dx.doi.org/10.1042/bio03006031.

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Douglas Kell was Professor of Bioanalytical Science at the University of Manchester and Director of the BBSRC-funded Manchester Centre for Integrative Systems Biology before taking over as Chief Executive of the BBSRC in October 2008. He studied at the University of Oxford and then did research at Aberystwyth University. He joined UMIST (University of Manchester Institute of Science and Technology) in 2002. (UMIST merged with the Victoria University of Manchester to form The University of Manchester in 2004.)
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4

Clarke, Catherine F. "New advances in coenzyme Q biosynthesis." Protoplasma 213, no. 3-4 (September 2000): 134–47. http://dx.doi.org/10.1007/bf01282151.

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5

Carcopino, Xavier, Didier Raoult, Florence Bretelle, Léon Boubli, and Andreas Stein. "Q Fever during Pregnancy." Annals of the New York Academy of Sciences 1166, no. 1 (May 2009): 79–89. http://dx.doi.org/10.1111/j.1749-6632.2009.04519.x.

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6

MARRIE, THOMAS J. "Q Fever in Octogenarians." Annals of the New York Academy of Sciences 590, no. 1 Rickettsiolog (June 1990): 266–70. http://dx.doi.org/10.1111/j.1749-6632.1990.tb42230.x.

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7

Crofts, Antony R. "The Q-cycle – A Personal Perspective." Photosynthesis Research 80, no. 1-3 (2004): 223–43. http://dx.doi.org/10.1023/b:pres.0000030444.52579.10.

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8

Thomson, Jane. "Q&A: Promoting questions and dialogue in school science." Biochemist 32, no. 1 (February 1, 2010): 32–33. http://dx.doi.org/10.1042/bio03201032.

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Getting teenagers to ask good questions in science is not as easy as one would think. Many able pupils seem happy to passively absorb information without asking many questions, and to some extent the teacher might be forgiven for making the best of it by skipping through the syllabus, merrily ticking off learning objectives without losing too much sleep. While most teachers would agree that this way of learning science is not exactly ideal, questions concerning how to get pupils to become more inquisitive about science and how to foster a climate of questioning in lessons have been stagnating in the ether of secondary schools' prep rooms across the land for some time.
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9

Alshehri, Noura, and Muhammad Akram. "Generalized Bifuzzy Lie Subalgebras." Scientific World Journal 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/365065.

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We introduce the concept of(γ,δ)-bifuzzy Lie subalgebra, whereγ,δare any two of{∈,q,∈∨q,∈∧q}withγ≠∈∧q, by using belongs to relation(∈)and quasi-coincidence with relation(q)between bifuzzy points and bifuzzy sets and discuss some of its properties. Then we introduce bifuzzy soft Lie subalgebras and investigate some of their properties.
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10

BLONDEAU, J., L. YATES, R. MARTIN, T. MARRIE, P. UKOLI, and A. THOMAS. "Q Fever in Sokoto, Nigeria." Annals of the New York Academy of Sciences 590, no. 1 Rickettsiolog (June 1990): 281–82. http://dx.doi.org/10.1111/j.1749-6632.1990.tb42233.x.

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11

Lenaz, G., Carla Bovina, Cinzia Castelluccio, Marika Cavazzoni, E. Estornell, Romana Fato, J. R. Huertas, et al. "Modes of coenzyme Q function in electron transfer." Protoplasma 184, no. 1-4 (March 1995): 50–62. http://dx.doi.org/10.1007/bf01276901.

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12

Uçar, Faruk. "q-Sumudu Transforms ofq-Analogues of Bessel Functions." Scientific World Journal 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/327019.

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The main purpose of this paper is to evaluateq-Sumudu transforms of a product ofq-Bessel functions. Interesting special cases of theorems are also discussed. Further, the results proved in this paper may find certain applications ofq-Sumudu transforms to the solutions of theq-integrodifferential equations involvingq-Bessel functions. The results may help to extend theq-theory of orthogonal functions.
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13

RAOULT, D., P. Y. LEVY, J. R. HARLÉ, J. ETIENNE, P. MASSIP, F. GOLDSTEIN, M. MICOUD, et al. "Chronic Q Fever: Diagnosis and Follow-Up." Annals of the New York Academy of Sciences 590, no. 1 Rickettsiolog (June 1990): 51–60. http://dx.doi.org/10.1111/j.1749-6632.1990.tb42206.x.

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14

Iranmanesh, Ali, Yaser Alizadeh, and Bahman Taherkhani. "Computing the Szeged and PI Indices of VC5C7[p,q] and HC5C7[p,q] Nanotubes." International Journal of Molecular Sciences 9, no. 2 (February 5, 2008): 131–44. http://dx.doi.org/10.3390/ijms9020131.

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15

Liu, Shu-Sen. "Mitochondrial Q cycle-derived superoxide and chemiosmotic bioenergetics." Annals of the New York Academy of Sciences 1201, no. 1 (July 2010): 84–95. http://dx.doi.org/10.1111/j.1749-6632.2010.05632.x.

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16

RUIZ, CARLOS, JOAQUIN LUNA, and ALVARO DUQUE. "A Filtration of the Space 𝒥= Q ∩ [0,1]." Annals of the New York Academy of Sciences 767, no. 1 (December 27, 2006): 210–16. http://dx.doi.org/10.1111/j.1749-6632.1995.tb55909.x.

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17

RAOULT, DIDIER. "Host Factors in the Severity of Q Fever." Annals of the New York Academy of Sciences 590, no. 1 Rickettsiolog (June 1990): 33–38. http://dx.doi.org/10.1111/j.1749-6632.1990.tb42204.x.

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18

Wang, Zhao-Quan, Xing-Yu Li, Dong-Bao Hu, and Chun-Lin Long. "Cytotoxic garcimultiflorones K–Q, lavandulyl benzophenones from Garcinia multiflora branches." Phytochemistry 152 (August 2018): 82–90. http://dx.doi.org/10.1016/j.phytochem.2018.04.019.

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19

Li, Zhengwen, Mohamed Moalin, Ming Zhang, Lily Vervoort, Alex Mommers, and Guido R. M. M. Haenen. "Delocalization of the Unpaired Electron in the Quercetin Radical: Comparison of Experimental ESR Data with DFT Calculations." International Journal of Molecular Sciences 21, no. 6 (March 16, 2020): 2033. http://dx.doi.org/10.3390/ijms21062033.

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In the antioxidant activity of quercetin (Q), stabilization of the energy in the quercetin radical (Q•) by delocalization of the unpaired electron (UE) in Q• is pivotal. The aim of this study is to further examine the delocalization of the UE in Q•, and to elucidate the importance of the functional groups of Q for the stabilization of the UE by combining experimentally obtained spin resonance spectroscopy (ESR) measurements with theoretical density functional theory (DFT) calculations. The ESR spectrum and DFT calculation of Q• and structurally related radicals both suggest that the UE of Q• is mostly delocalized in the B ring and partly on the AC ring. The negatively charged oxygen groups in the B ring (3′ and 4′) of Q• have an electron-donating effect that attract and stabilize the UE in the B ring. Radicals structurally related to Q• indicate that the negatively charged oxygen at 4′ has more of an effect on concentrating the UE in ring B than the negatively charged oxygen at 3′. The DFT calculation showed that an OH group at the 3-position of the AC ring is essential for concentrating the radical on the C2–C3 double bond. All these effects help to explain how the high energy of the UE is captured and a stable Q• is generated, which is pivotal in the antioxidant activity of Q.
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20

Zhu, Fei, Quan Liu, Hui Wang, Xiaoke Zhou, and Yuchen Fu. "Unregistered Biological Words Recognition by Q-Learning with Transfer Learning." Scientific World Journal 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/173290.

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Unregistered biological words recognition is the process of identification of terms that is out of vocabulary. Although many approaches have been developed, the performance approaches are not satisfactory. As the identification process can be viewed as a Markov process, we put forward a Q-learning with transfer learning algorithm to detect unregistered biological words from texts. With the Q-learning, the recognizer can attain the optimal solution of identification during the interaction with the texts and contexts. During the processing, a transfer learning approach is utilized to fully take advantage of the knowledge gained in a source task to speed up learning in a different but related target task. A mapping, required by many transfer learning, which relates features from the source task to the target task, is carried on automatically under the reinforcement learning framework. We examined the performance of three approaches with GENIA corpus and JNLPBA04 data. The proposed approach improved performance in both experiments. The precision, recall rate, andFscore results of our approach surpassed those of conventional unregistered word recognizer as well as those of Q-learning approach without transfer learning.
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21

PARETSKY, DAVID. "The Biology of Coxiella burnetii and the Pathobiochemistry of Q Fever and Its Endotoxicosis." Annals of the New York Academy of Sciences 590, no. 1 Rickettsiolog (June 1990): 416–21. http://dx.doi.org/10.1111/j.1749-6632.1990.tb42249.x.

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22

Li, Baode, Dachun Yang, and Wen Yuan. "Anisotropic Hardy Spaces of Musielak-Orlicz Type with Applications to Boundedness of Sublinear Operators." Scientific World Journal 2014 (2014): 1–19. http://dx.doi.org/10.1155/2014/306214.

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Letφ:ℝn×[0,∞)→[0,∞)be a Musielak-Orlicz function andAan expansive dilation. In this paper, the authors introduce the anisotropic Hardy space of Musielak-Orlicz type,HAφ(ℝn), via the grand maximal function. The authors then obtain some real-variable characterizations ofHAφ(ℝn)in terms of the radial, the nontangential, and the tangential maximal functions, which generalize the known results on the anisotropic Hardy spaceHAp(ℝn)withp∈(0,1]and are new even for its weighted variant. Finally, the authors characterize these spaces by anisotropic atomic decompositions. The authors also obtain the finite atomic decomposition characterization ofHAφ(ℝn), and, as an application, the authors prove that, for a given admissible triplet(φ,q,s), ifTis a sublinear operator and maps all(φ,q,s)-atoms withq<∞(or all continuous(φ,q,s)-atoms withq=∞) into uniformly bounded elements of some quasi-Banach spacesℬ, thenTuniquely extends to a bounded sublinear operator fromHAφ(ℝn)toℬ. These results are new even for anisotropic Orlicz-Hardy spaces onℝn.
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23

Syah, Yana M., Sjamsul A. Achmad, Emilio L. Ghisalberti, Euis H. Hakim, Lukman Makmur, and Didin Mujahidin. "Artoindonesianins Q–T, four isoprenylated flavones from Artocarpus champeden Spreng. (Moraceae)." Phytochemistry 61, no. 8 (December 2002): 949–53. http://dx.doi.org/10.1016/s0031-9422(02)00366-7.

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24

FAST, STEPHEN H. "The Cardinal Number d and Convergent Sequences in Q." Annals of the New York Academy of Sciences 704, no. 1 Papers on Gen (December 1993): 126–28. http://dx.doi.org/10.1111/j.1749-6632.1993.tb52514.x.

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25

SCRIMGEOUR, E. M., S. I. N. AL-ISMAILY, J. M. ROLAIN, S. H. S. AL-DHAHRY, H. S. EL-KHATIM, and D. RAOULT. "Q Fever in Human and Livestock Populations in Oman." Annals of the New York Academy of Sciences 990, no. 1 (June 2003): 221–25. http://dx.doi.org/10.1111/j.1749-6632.2003.tb07366.x.

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26

BOGÁR, PÁL, JÁNOS A. BERGOU, and MARK HILLERY. "Quantum State Engineering in Pump-coupled High-Q Micromasersa." Annals of the New York Academy of Sciences 755, no. 1 (April 1995): 110–20. http://dx.doi.org/10.1111/j.1749-6632.1995.tb38961.x.

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27

TOKAREVICH, N. K., O. A. FREILYKHMAN, N. M. TITOVA, I. R. ZHELTAKOVA, N. A. RIBAKOVA, and E. V. VOROBEYCHIKOV. "Anthropogenic Effects on Changing Q Fever Epidemiology in Russia." Annals of the New York Academy of Sciences 1078, no. 1 (October 1, 2006): 120–23. http://dx.doi.org/10.1196/annals.1374.018.

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28

Robertson, Miranda. "Q&A: Re-review opt-out and painless publishing." BMC Biology 11, no. 1 (2013): 18. http://dx.doi.org/10.1186/1741-7007-11-18.

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29

McEvoy, Ann L., Derek Greenfield, Mark Bates, and Jan Liphardt. "Q&A: Single-molecule localization microscopy for biological imaging." BMC Biology 8, no. 1 (2010): 106. http://dx.doi.org/10.1186/1741-7007-8-106.

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30

Pavlovic, Miroslav. "Definition and Properties of the Libera Operator on Mixed Norm Spaces." Scientific World Journal 2014 (2014): 1–15. http://dx.doi.org/10.1155/2014/590656.

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We consider the action of the operatorℒg(z)=(1-z)-1∫z1‍f(ζ)dζon a class of “mixed norm” spaces of analytic functions on the unit disk,X=Hα,νp,q, defined by the requirementg∈X⇔r↦(1-r)αMp(r,g(ν))∈Lq([0,1],dr/(1-r)), where1≤p≤∞,0<q≤∞,α>0, andνis a nonnegative integer. This class contains Besov spaces, weighted Bergman spaces, Dirichlet type spaces, Hardy-Sobolev spaces, and so forth. The expressionℒgneed not be defined forganalytic in the unit disk, even forg∈X. A sufficient, but not necessary, condition is that∑n=0∞‍|g^(n)|/(n+1)<∞. We identify the indicesp,q,α, andνfor which1∘ℒis well defined onX,2∘ℒacts fromXtoX,3∘the implicationg∈X⇒∑n=0∞‍|g^(n)|/(n+1)<∞holds. Assertion2∘extends some known results, due to Siskakis and others, and contains some new ones. As an application of3∘we have a generalization of Bernstein’s theorem on absolute convergence of power series that belong to a Hölder class.
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31

He, X. H., W. R. Horwath, R. J. Zasoski, Z. Aanderud, and C. S. Bledsoe. "Nitrogen sink strength of ectomycorrhizal morphotypes of Quercus douglasii, Q. garryana, and Q. agrifolia seedlings grown in a northern California oak woodland." Mycorrhiza 18, no. 1 (September 25, 2007): 33–41. http://dx.doi.org/10.1007/s00572-007-0150-5.

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32

Seymour, Roger S., Vanya Bosiocic, Edward P. Snelling, Prince C. Chikezie, Qiaohui Hu, Thomas J. Nelson, Bernhard Zipfel, and Case V. Miller. "Cerebral blood flow rates in recent great apes are greater than in Australopithecus species that had equal or larger brains." Proceedings of the Royal Society B: Biological Sciences 286, no. 1915 (November 13, 2019): 20192208. http://dx.doi.org/10.1098/rspb.2019.2208.

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Brain metabolic rate (MR) is linked mainly to the cost of synaptic activity, so may be a better correlate of cognitive ability than brain size alone. Among primates, the sizes of arterial foramina in recent and fossil skulls can be used to evaluate brain blood flow rate, which is proportional to brain MR. We use this approach to calculate flow rate in the internal carotid arteries ( Q ˙ ICA ) , which supply most of the primate cerebrum. Q ˙ ICA is up to two times higher in recent gorillas, chimpanzees and orangutans compared with 3-million-year-old australopithecine human relatives, which had equal or larger brains. The scaling relationships between Q ˙ ICA and brain volume ( V br ) show exponents of 1.03 across 44 species of living haplorhine primates and 1.41 across 12 species of fossil hominins. Thus, the evolutionary trajectory for brain perfusion is much steeper among ancestral hominins than would be predicted from living primates. Between 4.4-million-year-old Ardipithecus and Homo sapiens , V br increased 4.7-fold, but Q ˙ ICA increased 9.3-fold, indicating an approximate doubling of metabolic intensity of brain tissue. By contrast, Q ˙ ICA is proportional to V br among haplorhine primates, suggesting a constant volume-specific brain MR.
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33

Wang, XiLe, XiaoLu Xiong, Stephen Graves, John Stenos, and BoHai Wen. "Protein array of Coxiella burnetii probed with Q fever sera." Science China Life Sciences 56, no. 5 (May 2013): 453–59. http://dx.doi.org/10.1007/s11427-013-4472-6.

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34

HAMZIĆ, S., E. BESLAGIĆ, and Š. ZVIZDIĆ. "Significance of Q Fever Serologic Diagnosis in Clinically Suspect Patients." Annals of the New York Academy of Sciences 990, no. 1 (June 2003): 365–68. http://dx.doi.org/10.1111/j.1749-6632.2003.tb07392.x.

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35

VOROBEYCHIKOV, E. V., G. M. KURTZER, A. Z. VASILENKO, and O. P. MISNIKOV. "Probabilistic Evaluation of Aspirating Doses of a Q Fever Pathogen." Annals of the New York Academy of Sciences 990, no. 1 (June 2003): 743–50. http://dx.doi.org/10.1111/j.1749-6632.2003.tb07454.x.

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36

MARRIE, THOMAS J. "A Comparison of Q Fever Endocarditis with Native Valve Endocarditis." Annals of the New York Academy of Sciences 590, no. 1 Rickettsiolog (June 1990): 61–67. http://dx.doi.org/10.1111/j.1749-6632.1990.tb42207.x.

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37

HAMZIC, S., E. BESLAGIC, and S. ZVIZDIC. "Serotesting of Human Q Fever Distribution in Bosnia and Herzegovina." Annals of the New York Academy of Sciences 1078, no. 1 (October 1, 2006): 133–36. http://dx.doi.org/10.1196/annals.1374.022.

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38

BESLAGIC, E., S. HAMZIC, O. BESLAGIC, and S. ZVIZDIC. "Public Health Problem of Zoonoses with Emphasis on Q Fever." Annals of the New York Academy of Sciences 1078, no. 1 (October 1, 2006): 203–5. http://dx.doi.org/10.1196/annals.1374.094.

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39

Li, Zhengwen, Mohamed Moalin, Ming Zhang, Lily Vervoort, Erik Hursel, Alex Mommers, and Guido R. M. M. Haenen. "The Flow of the Redox Energy in Quercetin during Its Antioxidant Activity in Water." International Journal of Molecular Sciences 21, no. 17 (August 21, 2020): 6015. http://dx.doi.org/10.3390/ijms21176015.

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Most studies on the antioxidant activity of flavonoids like Quercetin (Q) do not consider that it comprises a series of sequential reactions. Therefore, the present study examines how the redox energy flows through the molecule during Q’s antioxidant activity, by combining experimental data with quantum calculations. It appears that several main pathways are possible. Pivotal are subsequently: deprotonation of the 7-OH group; intramolecular hydrogen transfer from the 3-OH group to the 4-Oxygen atom; electron transfer leading to two conformers of the Q radical; deprotonation of the OH groups in the B-ring, leading to three different deprotonated Q radicals; and finally electron transfer of each deprotonated Q radical to form the corresponding quercetin quinones. The quinone in which the carbonyl groups are the most separated has the lowest energy content, and is the most abundant quinone. The pathways are also intertwined. The calculations show that Q can pick up redox energy at various sites of the molecule which explains Q’s ability to scavenge all sorts of reactive oxidizing species. In the described pathways, Q picked up, e.g., two hydroxyl radicals, which can be processed and softened by forming quercetin quinone.
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40

G�mez-D�az, C., M. I. Bur�n, F. J. Alca�n, R. Gonz�lez-Ojeda, J. A. Gonz�lez-Reyes, R. I. Bello, M. D. Herman, P. Navas, and J. M. Villalba. "Effect of dietary coenzyme Q and fatty acids on the antioxidant status of rat tissues." Protoplasma 221, no. 1-2 (May 1, 2003): 11–17. http://dx.doi.org/10.1007/s00709-002-0067-y.

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41

Wang, Wenping, Irene Liparulo, Nicola Rizzardi, Paola Bolignano, Natalia Calonghi, Christian Bergamini, and Romana Fato. "Coenzyme Q Depletion Reshapes MCF-7 Cells Metabolism." International Journal of Molecular Sciences 22, no. 1 (December 28, 2020): 198. http://dx.doi.org/10.3390/ijms22010198.

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Mitochondrial dysfunction plays a significant role in the metabolic flexibility of cancer cells. This study aimed to investigate the metabolic alterations due to Coenzyme Q depletion in MCF-7 cells. Method: The Coenzyme Q depletion was induced by competitively inhibiting with 4-nitrobenzoate the coq2 enzyme, which catalyzes one of the final reactions in the biosynthetic pathway of CoQ. The bioenergetic and metabolic characteristics of control and coenzyme Q depleted cells were investigated using polarographic and spectroscopic assays. The effect of CoQ depletion on cell growth was analyzed in different metabolic conditions. Results: we showed that cancer cells could cope from energetic and oxidative stress due to mitochondrial dysfunction by reshaping their metabolism. In CoQ depleted cells, the glycolysis was upregulated together with increased glucose consumption, overexpression of GLUT1 and GLUT3, as well as activation of pyruvate kinase (PK). Moreover, the lactate secretion rate was reduced, suggesting that the pyruvate flux was redirected, toward anabolic pathways. Finally, we found a different expression pattern in enzymes involved in glutamine metabolism, and TCA cycle in CoQ depleted cells in comparison to controls. Conclusion: This work elucidated the metabolic alterations in CoQ-depleted cells and provided an insightful understanding of cancer metabolism targeting.
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42

Li, Yi-Ran, Wen-Jun Xu, Shan-Shan Wei, Wei-Jia Lu, Jun Luo, and Ling-Yi Kong. "Hyperbeanols F-Q, diverse monoterpenoid polyprenylated acylphloroglucinols from the flowers of Hypericum beanii." Phytochemistry 159 (March 2019): 56–64. http://dx.doi.org/10.1016/j.phytochem.2018.12.005.

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43

Silva, Helena G., Rómulo S. Sobral, Alexandre P. Magalhães, Leonor Morais-Cecílio, and M. Manuela R. Costa. "Genome-Wide Identification of Epigenetic Regulators in Quercus suber L." International Journal of Molecular Sciences 21, no. 11 (May 27, 2020): 3783. http://dx.doi.org/10.3390/ijms21113783.

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Modifications of DNA and histones, including methylation and acetylation, are critical for the epigenetic regulation of gene expression during plant development, particularly during environmental adaptation processes. However, information on the enzymes catalyzing all these modifications in trees, such as Quercus suber L., is still not available. In this study, eight DNA methyltransferases (DNA Mtases) and three DNA demethylases (DDMEs) were identified in Q. suber. Histone modifiers involved in methylation (35), demethylation (26), acetylation (8), and deacetylation (22) were also identified in Q. suber. In silico analysis showed that some Q. suber DNA Mtases, DDMEs and histone modifiers have the typical domains found in the plant model Arabidopsis, which might suggest a conserved functional role. Additional phylogenetic analyses of the DNA and histone modifier proteins were performed using several plant species homologs, enabling the classification of the Q. suber proteins. A link between the expression levels of each gene in different Q. suber tissues (buds, flowers, acorns, embryos, cork, and roots) with the functions already known for their closest homologs in other species was also established. Therefore, the data generated here will be important for future studies exploring the role of epigenetic regulators in this economically important species.
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44

HARRISON, ROBERT J., DUC J. VUGIA, and MICHAEL S. ASCHER. "Occupational Health Guidelines for Control of Q Fever in Sheep Research." Annals of the New York Academy of Sciences 590, no. 1 Rickettsiolog (June 1990): 283–90. http://dx.doi.org/10.1111/j.1749-6632.1990.tb42234.x.

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45

CHAO, C. C. "Identification, Cloning, and Expression of Potential Diagnostic Markers for Q Fever." Annals of the New York Academy of Sciences 1063, no. 1 (December 1, 2005): 76–78. http://dx.doi.org/10.1196/annals.1355.010.

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46

MARMION, B. "Q Fever Research Group (QRG), Adelaide: Activities-Exit Summary 1980-2004." Annals of the New York Academy of Sciences 1063, no. 1 (December 1, 2005): 181–86. http://dx.doi.org/10.1196/annals.1355.028.

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47

Zhang, Xuejian, Ting Peng, Xiaoke Shi, Dongmei Fang, Lin Tang, Fang Chen, Fei Wang, Guolin Zhang, and Yinggang Luo. "Diterpenoids caryopterisoids D - Q and iridoid glucoside derivatives caryopterisides F - H from Caryopteris glutinosa." Phytochemistry 180 (December 2020): 112534. http://dx.doi.org/10.1016/j.phytochem.2020.112534.

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48

Nakamura, Yasunori, Tetsuo Takeichi, Kentaro Kawaguchi, and Hiroaki Yamanouchi. "Purification of two forms of starch branching enzyme (Q-enzyme) from developing rice endosperm." Physiologia Plantarum 84, no. 3 (March 1992): 329–35. http://dx.doi.org/10.1111/j.1399-3054.1992.tb04672.x.

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49

Domżalska, Małgorzata, Wiesław Wiczkowski, Aleksandra Szczepkowska, Sylwia Chojnowska, Tomasz Misztal, Fruzsina R. Walter, Maria A. Deli, et al. "Effect of Lipopolysaccharide-Induced Inflammatory Challenge on β-Glucuronidase Activity and the Concentration of Quercetin and Its Metabolites in the Choroid Plexus, Blood Plasma and Cerebrospinal Fluid." International Journal of Molecular Sciences 22, no. 13 (July 1, 2021): 7122. http://dx.doi.org/10.3390/ijms22137122.

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Quercetin-3-glucuronide (Q3GA), the main phase II metabolite of quercetin (Q) in human plasma, is considered to be a more stable form of Q for transport with the bloodstream to tissues, where it can be potentially deconjugated by β-glucuronidase (β-Gluc) to Q aglycone, which easily enters the brain. This study evaluates the effect of lipopolysaccharide (LPS)-induced acute inflammation on β-Gluc gene expression in the choroid plexus (ChP) and its activity in blood plasma, ChP and cerebrospinal fluid (CSF), and the concentration of Q and its phase II metabolites in blood plasma and CSF. Studies were performed on saline- and LPS-treated adult ewes (n = 40) receiving Q3GA intravenously (n = 16) and on primary rat ChP epithelial cells and human ChP epithelial papilloma cells. We observed that acute inflammation stimulated β-Gluc activity in the ChP and blood plasma, but not in ChP epithelial cells and CSF, and did not affect Q and its phase II metabolite concentrations in plasma and CSF, except Q3GA, for which the plasma concentration was higher 30 min after administration (p < 0.05) in LPS- compared to saline-treated ewes. The lack of Q3GA deconjugation in the ChP observed under physiological and acute inflammatory conditions, however, does not exclude its possible role in the course of neurodegenerative diseases.
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Eseberri, Itziar, Claire Laurens, Jonatan Miranda, Katie Louche, Arrate Lasa, Cedric Moro, and Maria P. Portillo. "Effects of Physiological Doses of Resveratrol and Quercetin on Glucose Metabolism in Primary Myotubes." International Journal of Molecular Sciences 22, no. 3 (January 30, 2021): 1384. http://dx.doi.org/10.3390/ijms22031384.

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Phenolic compounds have emerged in recent years as an option to face insulin resistance and diabetes. The central aim of this study was: (1) to demonstrate that physiological doses of resveratrol (RSV) or quercetin (Q) can influence glucose metabolism in human myotubes, (2) to establish whether AMP-activated protein kinase (AMPK) and protein kinase B –PKB- (Akt) pathways are involved in this effect. In addition, the effects of these polyphenols on mitochondrial biogenesis and fatty acid oxidation were analysed. Myotubes from healthy donors were cultured for 24 h with either 0.1 μM of RSV or with 10 μM of Q. Glucose metabolism, such as glycogen synthesis, glucose oxidation, and lactate production, were measured with D[U-14C]glucose. β-oxidation using [1–14C]palmitate as well as the expression of key metabolic genes and proteins by Real Time PCR and Western blot were also assessed. Although RSV and Q increased pgc1α expression, they did not significantly change either glucose oxidation or β-oxidation. Q increased AMPK, insulin receptor substrate 1 (IRS-1), and AS160 phosphorylation in basal conditions and glycogen synthase kinase 3 (GSK3β) in insulin-stimulated conditions. RSV tended to increase the phosphorylation rates of AMPK and GSK3β. Both of the polyphenols increased insulin-stimulated glycogen synthesis and reduced lactate production in human myotubes. Thus, physiological doses of RSV or Q may exhibit anti-diabetic actions in human myotubes.
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