Academic literature on the topic 'Q99720'

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Journal articles on the topic "Q99720"

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Lin, Ying-Chuan, Zachary Beck, Garrett M. Morris, Arthur J. Olson, and John H. Elder. "Structural Basis for Distinctions between Substrate and Inhibitor Specificities for Feline Immunodeficiency Virus and Human Immunodeficiency Virus Proteases." Journal of Virology 77, no. 12 (2003): 6589–600. http://dx.doi.org/10.1128/jvi.77.12.6589-6600.2003.

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ABSTRACT We used feline immunodeficiency virus (FIV) protease (PR) as a mutational framework to define determinants for the observed substrate and inhibitor specificity distinctions between FIV and human immunodeficiency virus (HIV) PRs. Multiple-substitution mutants were constructed by replacing the residues in and around the active site of FIV PR with the structurally equivalent residues of HIV-1 PR. Mutants included combinations of three critical regions (FIV numbering, with equivalent HIV numbering in superscript): I3732V in the active core region; N5546M, M5647I, and V5950I in the flap re
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Usserbayev, Bekbolat, Kulyaisan Sultankulova, Yerbol Burashev, et al. "Genetic Variations of Three Kazakhstan Strains of the SARS-CoV-2 Virus." Viruses 17, no. 3 (2025): 415. https://doi.org/10.3390/v17030415.

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Prompt determination of the etiological agent is important in an outbreak of pathogens with pandemic potential, particularly for dangerous infectious diseases. Molecular genetic methods allow for arriving at an accurate diagnosis, employing timely preventive measures, and controlling the spread of the disease-causing agent. In this study, whole-genome sequencing of three SARS-CoV-2 strains was performed using the Sanger method, which provides high accuracy in determining nucleotide sequences and avoids errors associated with multiple DNA amplification. Complete nucleotide sequences of samples,
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Alshafie, Walaa, Maryam Fotouhi, Riham Ayoubi, et al. "Antibody Characterization Report for Sigma non-opioid intracellular receptor 1." November 4, 2021. https://doi.org/10.5281/zenodo.5644356.

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Head-to-head comparison of available commercial antibodies against Sigma non-opioid intracellular receptor 1 by immunoblot (Western blot), immunoprecipitation and immunofluorescence. The following study was funded in part by Genome Québec's Genomics Integration Program, awarded to the research laboratory of Peter S. McPherson. This work was supported by the ALS-Reproducible Antibody Platform (ALS-RAP), a public-private partnership established by three prominent ALS charities - the ALS Association (USA), the Motor Neurone Disease Association (UK), and th
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Shi, Yumeng, Jiahui Chen, Lei Cai, et al. "Uncovering the Hidden World of Aqueous Humor Proteins for Discovery of Biomarkers for Marfan Syndrome." Advanced Science, December 13, 2023. http://dx.doi.org/10.1002/advs.202303161.

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AbstractEctopia lentis is a hallmark of Marfan syndrome (MFS), a genetic connective tissue disorder affecting 1/5000 to 1/10 000 individuals worldwide. Early detection in ophthalmology clinics and timely intervention of cardiovascular complications can be lifesaving. In this study, a modified proteomics workflow with liquid chromatography‐tandem mass spectrometry (LC‐MS/MS)‐based data‐independent acquisition (DIA) and field asymmetric ion mobility spectrometry (FAIMS) to profile the proteomes of aqueous humor (AH) and lens tissue from MFS children with ectopia lentis is utilized. Over 2300 and
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Movaghar, Arezoo, David Page, Murray Brilliant, and Marsha Mailick. "Advancing artificial intelligence-assisted pre-screening for fragile X syndrome." BMC Medical Informatics and Decision Making 22, no. 1 (2022). http://dx.doi.org/10.1186/s12911-022-01896-5.

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Abstract Background Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and autism, is significantly underdiagnosed in the general population. Diagnosing FXS is challenging due to the heterogeneity of the condition, subtle physical characteristics at the time of birth and similarity of phenotypes to other conditions. The medical complexity of FXS underscores an urgent need to develop more efficient and effective screening methods to identify individuals with FXS. In this study, we evaluate the effectiveness of using artificial intelligence (AI) and electronic h
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Alshafie, Walaa, Maryam Fotouhi, Kathleen Southern, Peter S. McPherson, and Carl Laflamme. "Antibody Characterization Report for Ataxin-2." July 2, 2021. https://doi.org/10.5281/zenodo.5061824.

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Head to head comparison of available commercial antibodies against Ataxin-2 by immunoblot (Western blot), immunoprecipitation and immunofluorescence. The following study was funded in part by Genome Québec's Genomics Integration Program, awarded to the laboratory of Peter S. McPherson. This work is part of the ALS-Reproducible Antibody Platform (ALS-RAP), established as a public-private partnership by three prominent ALS charities - the ALS Association (USA), the Motor Neurone Disease Association (UK), and the ALS Society of Canada.
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Dissertations / Theses on the topic "Q99720"

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ZHONG, Chang-Zhi, та 鍾長志. "Gold(I)- and TfOH-Catalyzed Intramolecular Cyclization Reactions of Enynamides: Synthesis of Fused Bicyclic- and Spiro-γ-Lactams". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/q9972j.

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碩士<br>國立臺灣師範大學<br>化學系<br>104<br>The thesis contains two topics. The first part is the synthesis of bicyclic γ-lactams via gold(I)-catalyzed intramolecular cycloisomerization of six-membered ring 3-enynamides. The second part is the synthesis of spiro-γ-lactams via TfOH-catalyzed intramolecular cycloisomerization of N-tosyl protected 3-(((phenylethynyl)amino)methyl)cyclohex-2-enol. Six-membered ring aryl-substituted 3-enynamides, upon treatment with the gold catalyst, gave a 9-azatricyclo[5.2.1.03,10]decane intermediate, which was spontaneously oxidized to 7-aroyloctahydro-1H-isoindolone in air
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Lin, Hsiu-Ying, and 林秀穎. "The Research of Learning Community for Teachers’ Professional Development and Cooperative Learning for Students’ Learning Achievements in English courses: An Example of a Junior High School in Taipei." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/q9977g.

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碩士<br>國立東華大學<br>教育與潛能開發學系<br>105<br>The purpose of this study is to discuss how to enhance the teacher’s expertise in cooperative learning by co-planning, observing and debriefing. In order to improve the quality of English teaching, teachers encourage students to work in cooperative learning group, and teachers work in cooperative teams to assist students through “student-centered” instruction. The study reveals how learning was experienced by students and to provide a more in-depth reflection in their learning process. The data includes feedback sheets written by students, the researcher
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LIN, SHIOW-FANG, and 林秀芳. "Exploring the Association between Job Burnout and Health Productivity Loss among Health Administrats." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/q9979s.

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碩士<br>國立雲林科技大學<br>工業工程與管理系<br>108<br>The World Health Organization (WHO) has given workplace improvement recommendations to promote the occupational health of employees and improve organizational quality. However, the typical medical industry workplace—with a high degree of division of labour—has a highly complex environment. Faced with the current, dynamic environment in this industry, the work stress experienced by its employees today is greater than in the past, which adversely impacts their health and health-related productivity. In addition, their resultant job burnout has negative effect
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CHENG, CHU-HONG, and 鄭竹竤. "Energy and Exergy Analysis of Zeotropic Mixture Fluids in Transcritical Organic Rankine Cycle." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/q99228.

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碩士<br>國立勤益科技大學<br>機械工程系<br>107<br>The rapid development of industry, energy consumption is increasing day by day, resulting in environmental protection is particularly important. The use of the organic Rankine cycle (ORC) system to recover low-grade thermal energy and extract geothermal heat for power generation can effectively alleviate climate warming. Compared cause the ORC and transcritical organic Rankine cycle (TRC), TRC is gaining attention, TRC has lower exergy loss than ORC. The difference between the transcritical and subcritical systems is the heating process of the working fluid. W
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Yang, Jou-Chun, and 楊柔均. "MicroRNA-194 inhibits epithelial-mesenchymal transition in human breast cancer cells." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/q9978e.

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