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Relevant bibliographies by topics / QacA

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Journal articles

Academic literature on the topic 'QacA'

Author: Grafiati

Published: 6 September 2023

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Journal articles on the topic "QacA"

1

Bayer, A. S., L. I. Kupferwasser, M. H. Brown, et al. "Low-Level Resistance of Staphylococcus aureus to Thrombin-Induced Platelet Microbicidal Protein 1 In Vitro Associated with qacA Gene Carriage Is Independent of Multidrug Efflux Pump Activity." Antimicrobial Agents and Chemotherapy 50, no. 7 (2006): 2448–54. http://dx.doi.org/10.1128/aac.00028-06.

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ABSTRACT Thrombin-induced platelet microbial protein 1 (tPMP-1), a cationic antimicrobial polypeptide released from thrombin-stimulated rabbit platelets, targets the Staphylococcus aureus cytoplasmic membrane to initiate its microbicidal effects. In vitro resistance to tPMP-1 correlates with survival advantages in vivo. In S. aureus, the plasmid-carried qacA gene encodes a multidrug transporter, conferring resistance to organic cations (e.g., ethidium [Et]) via proton motive force (PMF)-energized export. We previously showed that qacA also confers a tPMP-1-resistant (tPMP-1r) phenotype in vitr

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2

Kawai, Mako, Sakuo Yamada, Ai Ishidoshiro, Yoshihiro Oyamada, Hideaki Ito, and Jun-ichi Yamagishi. "Cell-wall thickness: possible mechanism of acriflavine resistance in meticillin-resistant Staphylococcus aureus." Journal of Medical Microbiology 58, no. 3 (2009): 331–36. http://dx.doi.org/10.1099/jmm.0.004184-0.

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Acriflavine resistance in the clinical meticillin-resistant Staphylococcus aureus isolate KT24 was found not to be mediated by multidrug efflux pumps encoded by qacA/B, smr, qacE, qacG, qacH, qacJ or norA. Early uptake and accumulation of ethidium bromide in MRSA KT24 was significantly lower than that in a susceptible strain, although the efflux rates were similar. Therefore, a permeability barrier in MRSA KT24 may be the conceivable mechanism of acriflavine resistance. Interestingly, it was found that MRSA KT24 had a significantly thickened cell wall, and that cell-wall thickness increased gr

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3

He, Gui-Xin, Michael Landry, Huizhong Chen, et al. "Detection of benzalkonium chloride resistance in community environmental isolates of staphylococci." Journal of Medical Microbiology 63, no. 5 (2014): 735–41. http://dx.doi.org/10.1099/jmm.0.073072-0.

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We isolated a total of 653 strains from 64 community environmental samples in Massachusetts, USA. Among these isolates, 9.65 % (63 strains) were benzalkonium chloride (BC)-resistant staphylococci. All BC-resistant strains were collected from surfaces upon which antibacterial wipes or antibacterial sprays containing 0.02–0.12 % BC had frequently been used in the fitness centres. However, isolates from surfaces upon which antibacterial wipes or antibacterial sprays had not been used were all sensitive to BC. All BC-resistant strains were also resistant to erythromycin, penicillin and ampicillin.

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4

Nakaminami, Hidemasa, Norihisa Noguchi, and Masanori Sasatsu. "Fluoroquinolone Efflux by the Plasmid-Mediated Multidrug Efflux Pump QacB Variant QacBIII in Staphylococcus aureus." Antimicrobial Agents and Chemotherapy 54, no. 10 (2010): 4107–11. http://dx.doi.org/10.1128/aac.01065-09.

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ABSTRACT Plasmids that carry the multidrug efflux genes qacA and qacB are widely distributed in methicillin-resistant Staphylococcus aureus (MRSA). Although the QacA and QacB proteins are similar to each other, their respective substrate specificities may differ. We investigated the variability and structure-function relationships of QacA and QacB in MRSA isolates. The amino acid sequences of 7 QacA and 25 QacB proteins showed that QacB was present in three variants, designated QacBII, QacBIII, and QacBIV, that were different from the prototypic QacB variant encoded by plasmid pSK23, which was

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5

Bjorland, Jostein, Terje Steinum, Marianne Sunde, Steinar Waage, and Even Heir. "Novel Plasmid-Borne Gene qacJ Mediates Resistance to Quaternary Ammonium Compounds in Equine Staphylococcus aureus, Staphylococcus simulans, and Staphylococcus intermedius." Antimicrobial Agents and Chemotherapy 47, no. 10 (2003): 3046–52. http://dx.doi.org/10.1128/aac.47.10.3046-3052.2003.

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ABSTRACT We identified a novel plasmid-borne gene (designated qacJ) encoding resistance to quaternary ammonium compounds (QACs) in three staphylococcal species associated with chronic infections in four horses. qacJ was located on a 2,650-bp plasmid (designated pNVH01), a new member of the pC194 family of rolling-circle replication plasmids. The 107-amino-acid protein, QacJ, showed similarities to known proteins of the small multidrug resistance family: Smr/QacC (72.5%), QacG (82.6%), and QacH (73.4%). The benzalkonium chloride MIC for a qacJ-containing recombinant was higher than those for ot

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6

Ergun, Y., Z. Cantekin, K. Gurturk, H. Solmaz, IH Ekin, and D. Ozturk. "Distribution of antiseptic resistance genes in Staphylococcus spp. from bovine mastitis." Veterinární Medicína 62, No. 4 (2017): 200–203. http://dx.doi.org/10.17221/265/2015-vetmed.

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The purpose of this study was the determination of antiseptic resistance genes (qacA/B and qacC) from staphylococcal mastitis in cattle in various regions of Turkey. In total, 283 isolates (Burdur: 36, Hatay: 47 and Van: 200) were studied, and the antiseptic resistance genes were detected using simplex PCR. The distribution of the qacA/B and qacC genes, mediating resistance against quaternary ammonium compounds, was found to vary among the different isolates. The qacA/B genes were found in three of the Burdur isolates, six of the Hatay isolates and seven of the Van isolates. The qacC gene was

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7

Et al., Saber. "Detection a New Antiseptic Resistant Variant of qac Gene in Some Multi Drug Resistant Staphylococcus aureus Isolated from Different Clinical Sources." Baghdad Science Journal 16, no. 3 (2019): 0571. http://dx.doi.org/10.21123/bsj.2019.16.3.0571.

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The increasing use of antiseptic compounds creates selective pressure cause emergence of antiseptic resistance among Staphylococcus aureus .Resistance mechanism of antiseptic is driven mainly by multi drug resistant (MDR) efflux protein.Sixty five isolates of S.aureuswere collected from different clinical sources and subjected to 11 antibiotics most of them are recognized by efflux systems as extruded substrates. Range of efflux activity was estimated using cartwheel method. Simultaneous discrimination of antiseptic coding genes (qacA/B, smr and norA)as well as nuc and mecA genes among multidr

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8

Paulsen, Ian T., Melissa H. Brown, and Ronald A. Skurray. "Characterization of the Earliest KnownStaphylococcus aureus Plasmid Encoding a Multidrug Efflux System." Journal of Bacteriology 180, no. 13 (1998): 3477–79. http://dx.doi.org/10.1128/jb.180.13.3477-3479.1998.

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ABSTRACT The staphylococcal qacB-encoding multidrug resistance plasmid pSK156, isolated from a clinical strain dating from 1951, was characterized. Comparison of the regions flanking qacB with other qacA- and qacB-encoding plasmids provided insights into the evolution and dissemination of these multidrug efflux genes and led to the detection of the earliest known copy of the insertion sequence IS257.

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9

Sidhu, Maan Singh, Even Heir, Truls Leegaard, Karianne Wiger та Askild Holck. "Frequency of Disinfectant Resistance Genes and Genetic Linkage with β-Lactamase Transposon Tn552 among Clinical Staphylococci". Antimicrobial Agents and Chemotherapy 46, № 9 (2002): 2797–803. http://dx.doi.org/10.1128/aac.46.9.2797-2803.2002.

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ABSTRACT A total of 61 strains of Staphylococcus aureus and 177 coagulase-negative staphylococcal strains were isolated from the blood of patients with bloodstream infections and from the skin of both children under cancer treatment and human immunodeficiency virus-positive patients. The MIC analyses revealed that 118 isolates (50%) were resistant to quaternary ammonium compound-based disinfectant benzalkonium chloride (BC). The frequencies of resistance to a range of antibiotics were significantly higher among BC-resistant staphylococci than among BC-sensitive staphylococci. Of 78 BC-resistan

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10

Kiley, John L., Dana M. Blyth, Dana M. Blyth, et al. "543. Biocide Resistance Genes in Klebsiella spp. Infections from Trauma Patients in Iraq and Afghanistan." Open Forum Infectious Diseases 6, Supplement_2 (2019): S259. http://dx.doi.org/10.1093/ofid/ofz360.612.

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Abstract Background Biocides play an integral role in infection control. Paralleling concern about rising incidence of multidrug-resistant (MDR) organisms is a concern for resistance to biocides. In small studies, several genes involved in the production of efflux pump proteins have been identified as markers of biocide resistance in Klebsiella spp., namely cepA, qacA, qacE, qac∆E, and acrA. This study aimed to analyze the Klebsiella spp. isolates of a previously defined military trauma group with a high incidence of MDR organisms for the presence of these genes and their correlation with othe

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