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Dissertations / Theses on the topic 'QD Organic Chemistry 241-441'

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Published: 4 June 2021
Last updated: 8 February 2022

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1

Oguzkaya, Funda. "Synthesis Of Macromolecular Catalyst Systems And Applications." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613565/index.pdf.

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SYNTHESIS OF MACROMOLECULAR CATALYST SYSTEMS AND APPLICATIONS Oguzkaya, Funda PhD., Department of Chemistry Supervisor: Prof. Dr. Cihangir Tanyeli September 2011, 144 pages The thesis mainly proposed to design macromolecular catalyst systems. Such catalysts should follow the way of &quot<br>Green Chemistry&quot<br>with including no metallic ions and have also the ability of reusability. Hence, nitroxide chemistry was chosen as the key point. Catalysts were synthesized with surely including TEMPO as the functional part as the most preferable nitroxide derivative. As a skeleton, norbornene
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2

Duygu, Arife Nese. "Synthesis Of Camptothecin Derivatives." Phd thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12606302/index.pdf.

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This study presents synthetic studies on camptothecin, a potent antitumor agent in order to improve its stability and solubility without reducing its activity. The study consists of the modification of camptothecin at 20-OH position a new strategy for the targeted and controlled release of the drug and modification at C-7 position to overcome the stability and solubility problems of the free drug. In the first part of the study, the 20-OH functional group of camptothecin was replaced with an unsymmetrical benzoin derivative that is able to release the drug under photolysis at 350 nm. The new
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3

Demirci, Sema. "Synthesis Of Heteroaryl Substituted Dihydrofuran And Dihydropyran Derivatives By Green Chemistry Approach." Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/2/12610966/index.pdf.

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The thesis subject is mainly involved in Green Chemistry approach. Thiophene, furan and pyridine carboxaldehydes were chosen as starting compounds and vinylation and allylation with Grignard reaction afforded the corresponding racemic heteroaryl substituted allylic and homoallylic alcohols. Subsequent resolution with enzymes (PS-Amano II, Lipozym and Novazym 435) gave enantiomerically enriched alcohols with the e.e. values varied between 65 and 99%. The absolute configurations of all substrates are known. As a result of O-allylation with the common procedure formed the feasible carbon backbone
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4

Emrullahoglu, Mustafa. "Novel Annulation Reactions For The Synthesis Of Substituted Pyrroles Darzens Reaction Of Acyl Phosphonates With &amp." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12610338/index.pdf.

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In the first part of this thesis, it is aimed to develope methods for the synthesis of trisubstituted pyrrrole derivatives. 2-Aminopyrrroles, alkoxy and sulfonyl substittitued pyrrole derivatives as well as pirolinones show interesting biological activities and are precursor of well know drugs. Although there is a number of methods for the synthesis of pyrroles, the synthesis of 2-aminopyrroles is limited to few works and is not widely known. Therefore, it is still an important goal in organic chemistry to improve methods for the synthesis of multifunctionalized pyrrole derivatives and pyrroli
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5

Isik, Murat. "Synthesis Of Various Camphor-based Chiral Pyridine Derivatives." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12605824/index.pdf.

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Chiral aromatic nitrogen heterocycles are finding many applications in asymmetric organic synthesis, particularly as ligands in the preparation of chiral metal complexes. Since camphor-based chiral auxiliaries are known to be especially effective, a number of pyridines fused to the camphor skeleton have been reported. It is well known that nicotinic acid and its derivatives exhibiting qualitatively the biological activity of nicotinamide, which acts as an electron acceptor in many biological redox reactions. In connection to our works, we attempted to develop short and convenient way to prepar
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6

Pinar, Ayse Nur. "Reaction Of Propargyl Aldehydes With Hydrazinium Salts: Synthesis Of Ferrocenyl And Phenyl Substituted Pyrazoles." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609769/index.pdf.

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Pyrazoles have been focus of a large number of investigations in the design and synthesis of novel biologically active agents that show remarkable medicinal activities. Although pyrazoles have been studied for over a century as an important class of heterocyclic compounds, they still continue to attract considerable attention due to the wide range of medicinal activities they possess. Recent studies have shown that combination of a ferrocenyl unit with structural features of pyrazoles can lead to products with enhanced or/and unexpected biological activity since several ferrocene derivatives h
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7

Karahan, Emrah. "Synthesis Of Furopyrrolone And Furopyridazinone Derivatives: A New Class Of Compounds." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12612937/index.pdf.

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ABSTRACT SYNTHESIS OF FUROPYRROLONE AND FUROPYRIDAZINONE DERIVATIVES: A NEW CLASS OF COMPOUNDS Karahan, Emrah M.Sc., Department of Chemistry Supervisor: Prof. Dr. Metin Balci February 2011, 102 pages Furopyrrolone has a bicyclic structure consisting of furan and a pyrrolone ring. It is isoelectronic with isoindolinone which is also a heterocyclic organic compound. It has a bicyclic structure, consisting of a benzene ring fused to a five-membered nitrogen containing pyrrolone ring. Pyrrolones, pyrrolidines, pyrrolidinones, pyridazines and pyridazinones are precursors to many pharmaceutic
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8

Kilikli, Ahmet Alper. "Development Of New Synthetic Methodologies For Indole Derivatives: Chemistry Of Homophthalic Acid." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12611521/index.pdf.

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Synthesizing nitrogen containing heterocyclic compounds is one of the leading research areas throughout the organic chemistry due to their significant activities on biological systems. Among the various biologically active molecules, indole derivatives are of prime importance on the grounds of their proven clinical roles. Objective of this study is to synthesize new indole derivatives those may contribute treatment of several diseases like their analogues via a recently developed synthetic methodology. Besides this, another objective is to observe and discuss effects of two different substitue
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9

Ozcan, Sevil. "Development Of New Synthetic Methodologies For The Synthesis Of Unusual Isocoumarin And Indole Derivatives:the Chemistry Of Homophthalic Acid." Phd thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/3/12608197/index.pdf.

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Many heterocyclic compounds containing nitrogen, oxygen and sulfur show wide range of physiological activities and their synthesis has always been attracted the interest of chemists. The aim of this research is to develop new synthetic methodologies leading to the synthesis of new derivatives of isocoumarines, indoles, isoquinolines, benzodiazepinones and quinazolines, which have been found to show important biological activities. Starting from homophthalic acid and bishomophthalic acid the corresponding acyl azides were proposed to be synthesized, which then would be used for the synthesis of
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10

Yilmaz, Mahmut Deniz. "Light Harvesting And Efficient Energy Transfer In Boron Dipyrrin (bodipy) Functionalized Perylene Diimide Dyads." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/2/12607376/index.pdf.

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An antenna for light harvesting is an organized multicomponent system in which several chromophoric molecular species absorb the incident light and channel the excitation energy to a common acceptor component. In this study, Click chemistry has been successfully applied in the synthesis of a bay region tetraboron dipyrrin (BODIPY) appended perylenediimide (PDI). This light-harvesting molecule presents a large cross section for the absorption of light in the visible region. Excitation energy is efficiently channeled to the perylenediimide core. This novel antenna system is the first demonstrati
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11

Kutuk, Ilker. "Design And Synthesis Of Near-ir Emitting Fluorescent Chemosensors For Transition Metal Ions." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12609561/index.pdf.

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Supramolecular chemistry is an emerging field of chemistry which has attracted much attention in recent years as a result of its broad applicability in many areas. Thus, the design of functional supramolecular systems is strongly in demand in this field. For this purpose, we have developed near-IR emitting ratiometric fluorescent chemosensors for transition metal ions. Judicious placement of dithiodioxaazamacrocycles on the BODIPY chromophore generates this chemosensor which is selective for Hg(II) ions and both absorption and emission spectra display large changes that would allow ratiometr
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12

Cakmak, Yusuf. "Phenylethynyl-bodipy Oligomers: Bright Dyes And Fluorescent Building Blocks." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12609893/index.pdf.

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Supramolecular chemistry is an emerging field of chemistry which has attracted much attention in recent years as a result of its broad applicability in many areas. Thus, the design of functional supramolecular systems is strongly in demand in this field. For this purpose, we have developed novel phenylethynyl-BODIPY oligomer series which have absorption and emission maxima at the red part of the visible region of electromagnetic spectrum. Careful design to assemble the decyl groups to the system allowed us to dissolve the molecules in organic solvents easily. That`s why, not only we could char
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13

Gumus, Selcuk. "Investigation Of Novel Topological Indices And Their Applications In Organic Chemistry." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/2/12611019/index.pdf.

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Numerical descriptors, beginning with Wiener, and then named topological indices by Hosoya, have gained gradually increasing importance along with other descriptors for use in QSAR and QSPR studies. Being able to estimate the physical or chemical properties of a yet nonexistent substance as close as possible is very important due to huge consumption of time and money upon direct synthesis. In addition, one may face safety problem as in the case of explosives. There have been almost hundred topological indices so far in the chemical graph theory literature. However, there is no topological inde
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14

Kapakli, Fadile. "New Strategy For The Synthesis Of Chiral N-substituted-3,4-dialkoxypyrrole From 2,5-dihydro-2,5-dimethoxyfuran." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/3/12607334/index.pdf.

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NEW STRATEGY FOR THE SYNTHESIS OF CHIRAL N-SUBSTITUTED-3,4-DIALKOXYPYRROLE FROM 2,5-DIHYDRO-2,5-DIMETHOXYFURAN KAPAKLI, FADiLE M.S., Department of Chemistry Supervisor : Prof. Dr. Cihangir Tanyeli July 2006, 80 pages Pyrroles are very valuable class of substances which have wide usage area in organic synthesis. In this study, chiral 3,4-dialkoxy-N-substituted pyrrole derivatives were synthesized. These compounds are widely used as building blocks for the synthesis of natural compounds that have focused on heterocyclic rings in their structures. In addition, chiral pyrrole derivatives can
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15

Atalar, Taner. "Molecular Design Of Some Potential Explosives." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12610318/index.pdf.

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With existing energetic materials, the on going demand from the user for increased performance with reduced vulnerability induces the synthesis of novel explosives. The need to control costs ensured that theoretical methods can help to eliminate any poor candidates due to performance and safety problems. Thus, this study is aimed to design of some potential high explosive molecules which have high detonation properties and are also insensitive. Presently 65 molecules were studied and 54 of them were handled for the first time in the literature. The detonation properties have been evaluated wit
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16

Atilgan, Serdar. "A Sensitive And Selective Ratiometric Near Ir Fluorescent Probes For Zinc And Mercury Ions Based On The Distyryl-bodipy Fluorophore." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12610842/index.pdf.

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Near-IR dyes that absorb and emit in the red visible or near-IR region have attracted great interest in the fields of medicinal chemistry and biochemistry for the last few decades. This interest is due to the multiple notes of metal ions in biological and enviromental processes. Therefore the development of cation selective and sensitive sensors have been a hot subject for many researchers. Consequently, fluorescence based sensors are the most efficient and favorable ones among its counterparts in the field of sensor research. In this study, we have targeted to synthesize BODIPY based near-IR
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17

Kokturk, Mustafa. "Synthesis Of Ferrocenylidene Cyclopentenediones." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12606316/index.pdf.

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SYNTHESIS OF FERROCENYLIDENE CYCLOPENTENEDIONES K&ouml<br>kt&uuml<br>rk, Mustafa M.S., Department of Chemistry Supervisor: Assoc. Prof. Dr. Metin Zora August 2005, 83 pages 2-Arylidine-4-cyclopentene-1,3-diones are known to be antitumor agents. Incorporation of the essential structures of such compounds with a ferrocene moiety instead of an aryl group could provide subtances with enhanced antitumor activities since some ferrocene derivatives have already proved to be active against a number of tumors. Thus, we have investigated the squarate-based synthesis of 2-ferrocenylidene-4-cyclope
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18

Gunay, Neset Batuhan. "Studies Directed Towards The Synthesis Of Imatinib Mesylate ((gleevec), 4-(4-methyl-piperazin-1- Ylmethyl)-n-[4- Methyl-3-(4-pyridin-3-yl-pyrimidin-2- Ylamino)-phenyl]- Benzamide Methanesulfonate) Analogs." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12610181/index.pdf.

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Imatinib mesylate is indicated for the treatment of chronic myeloid leukemia (CML) and unresectable and/or metastatic malignant gastrointestinal stromal tumors (GIST). By the application of this anticancer drug, problems occurs in terms of stability and activity. Computer assisted design (CAD) works showed that the modification of the B and C part molecule can increase the effectivity of the drug. The new derivatives of the drug will be obtained to change some part of the B and C segments. The total synthesis of a new imatinib mesylate will be done and the activity tests are going to be determ
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19

Karabiyikoglu, Sedef. "Synthesis Of Ferrocenyl Substituted Pyrazoles By Sonogashira And Suzuki-miyaura Cross-coupling Reactions." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12612139/index.pdf.

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Pyrazoles constitute one of the most important classes of heterocyclic compounds due to their interesting chemical and biochemical features. Researchers have studied many pyrazole containing structures for almost over a century in order to investigate the various biological activities possessed by these molecules. A new and important trend in these studies is to produce ferrocenyl substituted pyrazoles since ferrocene attracts considerable interest in the research field of organometallic and bioorganometallic chemistry because of its valuable chemical characteristics like high stability, low t
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20

Yazicioglu, Emre Yusuf. "Development Of Novel Asymmetric Catalysts For Various Transformations And Investigation Of A Rearrangement Reaction." Phd thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612536/index.pdf.

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A new class of pyridine and sulfur containing chiral compounds are synthesized. Camphor sulfonyl chloride is chosen as a valuable chiral starting compound. In our synthetic strategy, sulfonylchloride moiety is first reduced to corresponding thiol compound by using triphenylphosphine and then the resultant thiol will be converted to various alkyl, aryl substituted derivatives. The second part of our strategy includes the pyridine ring construction on the carbonyl side of camphor with the formation of &beta<br>-hydroxymethylene moiety followed by further reaction with various enamines. The resul
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21

Sezer, Serdar. "Remote Control Of The Diastereoselectivity In The Pauson." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613908/index.pdf.

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In this thesis, an intramolecular Pauson-Khand reaction of chiral enynes derived from homoallyl, allyl and homopropargyl alcohols is described. For this purpose, 2-heteroaryl substituted homoallyl, allyl and homopropargyl alcohols are easily and efficiently resolved through enzymatic resolution in a high ee (91-99%) with a known stereochemistry. Each enantiomerically enriched enyne derived from homoallyl and homopropargyl alcohols affords the conformationally most stable diastereomeric cyclopenta[c]pyran ring system as a sole product, whereas enantiomerically enriched enynes derived from allyl
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22

Akkoca, Hasan Ufuk. "Synthesis Of Bifunctional 2-aminodmap/prolinamide Organocatalysts And Their Use In Asymmetric Michael Reaction To Afford Warfarin." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12613984/index.pdf.

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In the first part of this thesis, the construction of the novel bifunctional proline-(1R,2R)-2-aminoDMAP organocatalyst backbone is described. Target compound has both Lewis base and Br&oslash<br>nsted acid catalaphoric sites. The Lewis base site is synthesized via selective mono-N-pyridilization of trans-(1R,2R)-cyclohexane-1,2-diamine by Cu catalysis and Br&oslash<br>nsted acid site is subsequently introduced by anchoring L-proline unit. In the second part, catalytic activities of organocatalysts are tested in asymmetric Michael addition reaction between a cyclic 1,3-dicarbonyl compound 4-hy
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23

Icli, Burcak. "Towards Autonomous Molecular Machines: Switching Coupled To An Oscillating Reaction." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/2/12608749/index.pdf.

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We have designed and synthesized a bistable pseudo-rotaxane carrying a fluorescent boradiazaindacene (BODIPY) unit. The intensity of the emission signal is dependent on the position of the cucurbituril (CB7) unit over the axle component. Thus, pH modulated switching of the CB7 wheel is accompanied by significant changes in the emission spectrum. Additionally, a thiosulfate-sulfite-iodate oscillating reaction which generates large amplitude pH oscillations can be carried out in the same solution. In such a solution, in response to changing pH, the position of the wheel component seems to change
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24

Dost, Zeynep. "Efficient Synthesis Of Novel Near Ir Emitting Distyrylboradiazaindacene Sensitizers For Photodynamic Therapy." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/2/12607377/index.pdf.

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Photodynamic therapy (PDT) is a noninvasive method of treating malignant tumors and age-related macular degeneration. Current practice of PDT is limited to a few functionalized porphyrins, however these compounds are not considered to be ideal drugs for use in PDT. Among the limitations, the most prominent is the low extinction coefficient of porphyrins in the body&amp<br>#8217<br>s therapeutic window. Therefore, there is a significant impetus to develop novel and better efficiency sensitizers for use in PDT. Boradiazaindacenes (BODIPY dyes or difluoroboradipyrrines) are well known fluorescent
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25

Kucukdisli, Murat. "Asymmetric Synthesis Of Chiral Camphor Fused Pyridine Type Novel Organocatalysts." Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/12610790/index.pdf.

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Chiral pyridines as organocatalysts have been used in asymmetric organic synthesis in recent years. The asymmetric synthesis of camphor fused pyridine type novel organocatalysts were perfomed starting from cheap and easily available natural (+)-camphor. Using camphor fused pyridine skeleton, six organocatalysts 29, 32, 33, 38, 40, and 41were successfully synthesized. The first four nucleophilic and Lewis base catalysts 29, 32, and 33 are different P-oxides and P,N-dioxides which were tested in allylation of aldehydes via allyltrichlorosilane. L-proline amide 38 and D-proline amide 40 can be n
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26

Sumer, Burak. "Synthesis Of 1,2-amino Alcohols Having Tertiary Alcohol Moiety." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607276/index.pdf.

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An applicable method for the racemic synthesis of 1,2-amino alcohols having tertiary alcohol moiety was developed. This method can be used as a general method for the synthesis of various 1,2-amino alcohols with various tertiary alcohol moieties by changing chloroacetone with different monohalo ketones, and with different aryl halides or alkyl halides. The resultant racemic 1,2-aminoe alcohols were tried to resolve by using various hydrolase type enzymes under different conditions by changing the parameters i.e. solvent, temperature and substrate: enzyme ratios. Finally, poorly resolved amino
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27

Bicer, Isil. "Chemoenzymatic Functionalization Of Cyclic 1,2-diketones." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607293/index.pdf.

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Chiral hydroxylated cyclopentane derivatives are important structural units in many biologically active compounds and are also important synthons for the asymmetric synthesis of natural products. Synthesis of these types of compounds in optically pure form found increased interest in pharmaceutical chemistry. For this purpose 5-acetoxy-3-methyl-2-methoxy-2-cyclopentene-1-one and 5-acetoxy-3-ethyl-2-methoxy-2-cyclopentene-1-one were acetoxylated using manganese (III) acetate at a&rsquo<br>positions. Enzyme catalyzed enantioselective hydrolysis of hydrolyzed acetoxy derivatives gives the corresp
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28

Akpinar, Handan. "Design And Synthesis Of Functional Molecular Squares." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607452/index.pdf.

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Self-assembly has big importance in synthesizing supramolecular structures. Highly fluorescent molecular squares with boradiazaindacene (BODIPY) building blocks were obtained via usage of metal driven self-asembly. The boradiazaindacene units were connected with the Pd(II) complex unit enforcing a near-90 degree angle between the building blocks. Thus, we believe we have the first example of BODIPY carrying fluorescent squares. With collective experience in BODIPY chemistry in our group, we may have the first example of functionalizable molecular square. Self-assembled light harvesting systems
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29

Atilgan, Serdar. "Water Soluble Distyryl-boradiazaindacenes As Efficient Photosensitizers For Photodynamic Therapy." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607601/index.pdf.

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Photodynamic therapy (PDT) is an emerging treatment modality for a range of disease classes, both cancerous and noncancerous. This has brought about an active pursiut of new PDT agents that can be optimized for the unique set of photophysical characteristics that are required for a succesful clinical agent. There are many reported or commercially available photosensitizers, but most have limitations, such as low photostability, or a limited usable range of solvent conditions. In this study, we introduced a novel class of extended conjugation water soluble boradiazaindacene dyes which are effi
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30

Erdem, Mine. "Asymmetric Synthesis Of Norbornene Based 1,4-aminoalcohol Derivatives And Applications In Asymmetric Diethylzinc Reactions." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/12608318/index.pdf.

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The asymmetric synthesis of chiral norbornene based 1,4-aminoalcohols and their applications in asymmetric diethylzinc addition reactions was perfomed starting from meso-anhydride 50. The desymmetrization of this meso-anhydride 50 was done by the usage of quinine or quinidine cinchona alkaloids with very high enantiomeric excess values (up to 98% ee) and chemical yields. The Quinidine-mediated desymmetrization of meso-anhydride 50 with methanol gave (2R,3S)-(+)-cis-monoester 51. The amination of this resulting compound with HMPTA was performed and by keeping the amine group constant, the amido
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31

Kaya, Nihal. "The Synthesis Of Hydroxymethyl Containing Cyclitol Derivatives." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12611063/index.pdf.

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Cyclitols have attracted a great deal of attention in recent years because of diverse biological activities exhibited by them and also synthetic usefulness in the synthesis of other natural compounds or pharmaceuticals. The presence of hydroxymethyl groups in many cyclitols units building natural products is also attracting a remarkable attention. In this study, novel synthetic strategies leading to cyclitol derivatives including hydroxymethyl groups were investigated and the syntheses of bis-homoinositol derivative 127 and hydroxymethyl containing conduritol derivative 137 were achieved succ
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32

Babiz, Hakan. "A New Method For Synthesis Of Aziridine 2-phosphonates And Their Biological Activities." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612595/index.pdf.

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A systematic study was carried out for the synthesis of aziridine 2-phosphonates by using two methods. First method is the classical Gabriel-Cromwell reaction and the second one is the modified version of Gabriel-Cromwell reaction which was developed in this thesis. In the first method, vinyl phosphonate was used as the starting material, then it was brominated to get 1,2-dibromoethyl phosphonate. HBr elimination from this compound, then reaction with different primary amines gave desired aziridinyl phosphonates in good yields. In the second method, easily available acetyl phosphonate was u
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33

Berk, Mujde. "Development Of New Synthetic Methodologies For Isoquinolone And Isoindolinone Derivatives." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12612145/index.pdf.

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ABSTRACT DEVELOPMENT OF NEW SYNTHETIC METHODOLOGIES FOR ISOQUINOLONE AND ISOINDOLINONE DERIVATIVES M&uuml<br>jde, Berk M.Sc., Department of Chemistry Supervisor: Prof. Dr. Metin Balci July 2010, 146 pages Due to the wide range of physiological activities, heterocycles containing nitrogen and oxygen have always attracted the interest of chemists. The objective of this research is to develop new synthetic routes to the synthesis of isoquinolone and isoindolinone derivatives starting from 2-(2-carboxyethyl)benzoic acid and homophthalic acid, respectively. The half ester produced from 2-(2-carboxy
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34

Subasi, Nuriye Tuna. "Novel Synthetic Methodologies For Heeocycles As Building Blocks In Drug Synthesis." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613028/index.pdf.

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Nitrogen containing heterocycles have always constituted a subject of great interest due to their wide presence in biologically important compounds so the development of efficient methods for the preparation of pyrrole derivatives and formation of new pyrrole-based heterocyclic compounds are an attractive goal in heterocyclic chemistry. In this study, starting from dimethoxytetrahydrofurane and amino acid esters, unsubstituted pyrrole derivatives, and treatment of amino acid esters with convenient chloroenones 1,2-disubstituted and 1,2,4-trisubstituted pyrrole derivatives were synthesized with
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35

Dengiz, Cagatay. "Acyl Azides: Application To The Synthesis Of Various Heterocycles." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613892/index.pdf.

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Pyrazoles, isoindolinones, benzodizepinones and dihydroquinolinones are very important heterocycles for their biological properties. Many pharmaceutical agents include these units as core structures. Reactive molecules such as acyl azides, free radicals and formyl groups are used as key step reactants in these studies. Regiospesific hydrolysis and esterifications are used to reach target starting materials. Two different methodology are used for critical ring closure steps. Benzodiazepinones, and isoindolinones are obtained by base mediated ring closure reactions whereas thionyl chloride media
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36

Ekmekci, Zeynep. "Development Of New Synthetic Methodologies For Aminocyclitols." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613906/index.pdf.

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Aminocyclitols are cyclitols in which at least one of the hydroxyl groups is exchanged with an amino functional group. In turn, they constitute a wide group of natural products with interesting biological properties and are widely distributed throughout. In particular, antibiotics containing an aminocyclitol unit have stimulated the development of synthetic methodologies in the search for analogues with enhanced pharmacological profiles. In this study, three different methods were applied to synthesize diaminoconduritol derivative 202. In the first method, 1,2,3,6-tetraphthalic anhydrate (196)
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37

Ergun, Merve. "Development Of New Synthetic Methodologies For Furan Fused Heterocycles." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615337/index.pdf.

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Furopyranones and furopyrrolones are furan-fused bicyclic heterocycles containing pyranone and pyrrolone framework respectively. Many natural products and pharmaceutical agents include these core structures. In this study, new synthetic methodologies were developed for the synthesis of furopyranone and furopyrrolone derivatives. In the first section of this thesis, methyl 2-(2-methoxy-2-oxoethyl)-3-furoate was hydrolyzed forming 2-(carboxymethyl)-3-furoic acid which underwent intramolecular cyclization reaction using two different methodologies forming furopyranone derivatives. In the second p
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38

Eymur, Serkan. "Development Of Novel Catalytic Methodologies For Carboncarbon Bond Construction." Phd thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12615303/index.pdf.

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Addition reactions of nucleophilic trifluoromethyltrimethylsilane (CF3TMS) to acyl phosphonates were investigated. Various acyl phosphonates reacted readily with CF3TMS in the presence of K2CO3 to give 1-alkyl-2,2,2-trifluoro-1-trimethylsilyloxyethylphosphonate in 70-90% yields. When benzoyl phosphonates were used as starting material, after addition of CF3, the formed alcoholate undergoes phosphonatephosphate rearrangement to form the acyl anion, followed by elimination of F- to give 1-aryldifluoroethenyl phosphates in 87-97% yields. The proline&ndash<br>thiourea host&ndash<br>guest complex
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39

Isbasar, Gullu Ceyda. "Distyryl-boradiazaindacenes As Red And Nir Switches." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/3/12608419/index.pdf.

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Two novel distyryl-boradiazaindacene dyes with dimethylaminophenyl and pyridyl appendages, display opposite spectral shifts on protonation with trifluoroacetic acid in organic solvents. This bidirectional switching of the dyes can be shown to be directly related to ICT donor and acceptor characteristics of the dyes. Thus, it has been demonstrated that the switching behavior of the red to NIR emitting dyes can be altered by simple structural modifications.
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40

Camur, Yakup. "A Computational Study On Nitrotriazine Derivatives." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12609362/index.pdf.

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In this study, all possible mono, di and trinitro-substituted triazine compounds as potential candidates for high energy density materials (HEDMs) have been investigated by using quantum chemical treatment. Computational chemistry is a valuable tool for estimating the potential candidates for high energy density materials. Geometric features and electronic structures of these nitro-substituted triazines have been systematically studied using ab initio and density functional theory (DFT, B3LYP) at the level of 6-31G(d,p), 6-31+G(d,p), 6-311G(d,p), 6-311+G(d,p), cc-pVDZ. Detonation performance
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41

Sudemen, Burak M. "Addition Of 1,3-dicarbonyl Compounds To The Cycloheptatriene Derivatives." Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/12611245/index.pdf.

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The one electron oxidant Mn(OAc)3 has been used for years for the oxidative addition of 1,3-dicarbonyls to alkenes to give dihydrofuranes. Since cycloheptatriene is in equilibrium with its valance isomer norcaradiene, it will be interesting to study the reaction of CHT derivatives with Mn(OAc)3 in the presence of 1,3-dicarbonyls. In our research, we have observed that unsubstituted cycloheptatriene gave CHT based products. However, when electron withdrawing -CN group was attached to C-7 position of CHT we obtained norcaradiene based products. We have also observed that there exist an equilibri
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42

Sunbul, Murat. "Asymmetric Synthesis Of Norbornene Based 1,4-amino Alcohol Derivatives And Applications In Asymmetric Transformations." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12606174/index.pdf.

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The asymmetric synthesis of cis-1,4-aminoalcohols with norbornene backbone was performed starting with simple and cheap anhydride 30. Quinine-mediated desymmetrization of anhydride 30 with methanol resulted in (2S,3R)-(-)-cis-hemiester 31 (98% e.e.). Chemoselective amination with HMPTA and NH4OH followed by LAH reduction afforded (2S,3R)-(+)-36 and (2S,3R)-(-)-37, respectively. The amidoester (2S,3R)-(-)-32 was transformed into chiral ligand (2S,3R)-(-)-35 with Grignard reaction followed by LAH reduction. The chiral ligands (2S,3R)-(-)-35, (2S,3R)-(+)-36 and (2S,3R)-(-)-37 were subjected to
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43

Turkmen, Yunus Emre. "Novel Studies On The Chemoenzymatic Synthesis Of Polychlorinated Bicyclic Systems And The Synthesis Of C2 And C3 Symmetric Chiral Ligands." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/3/12607340/index.pdf.

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Optically active polychlorinated bicyclic systems are important starting materials for the synthesis of complex target molecules. In the first part of the study, the syntheses of several racemic and meso hexachloronorbornene derivatives were executed successfully, starting from hexachlorocyclopentadiene. The enantio-enriched acetoxymethyl derivative (-)-2 and the hemiester (-)-6 were synthesized in high e.e. values by using several hydrolase type enzymes. The absolute configuration of (-)-2 was determined by transforming it to the corresponding norbornene derivative (-)-7 with known absolut
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44

Bilgic, Bora. "Design And Synthesis Of New Supramolecular Building Blocks Based On Oligo-bodipy Dyes." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/2/12609365/index.pdf.

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We have designed and synthesized a fluorescent, self-assembled molecular square containing a highly fluorescent well known flurophore boradiazaindacene (BODIPY) dye. Pt(II) complexes were used to hold together BODIPY derivatives and give the right angle to form the square structure. Usage of BODIPY fluorophore is very important on such structures because its variety of superior properties. BODIPY is a well studied fluorophore in our group and it is known that this self assembled square can be easily modified to any area of use it is needed.
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45

Yazici, Ceyda. "Synthesis Of 4-iodopyrazole Derivatives." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609750/index.pdf.

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Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The electrophilic cyclization of the acetylenic hydrazones initiated by molecular iodine could provide new ways of synthesizing biologically active 4-iodopyrazole derivatives, which are important precursors for the synthesis of highly substituted pyrazole derivatives. For this reason, we investigated the synthesis of 4-iodopyrazole derivatives, such as 1-aryl- 5-alkyl/aryl-4-iodopyrazoles, star
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46

Akbasoglu, Naime. "Synthesis Of Linkers And Mediators For Electrochemical Reactor Design And Enantiopure Synthon Preparation." Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/12610930/index.pdf.

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The production of enantiopure compounds can be achieved by using dehydrogenases as biocatalysts catalyzing reduction reactions of prochiral compounds such as ketones, aldehydes and nitriles. These dehydrogenases are cofactor dependent enzyme where cofactor is Nicotinamide dinucleotite having some restrictions that limits usage of dehydrogenases in organic synthesis including instability of cofactor in water and high cost. Therefore suitable regeneration method is needed and developed which are enzymatic and electrochemical. We will use an electrochemical approach for the regeneration of reduce
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47

Gumus, Aysegul. "Stereoselective Synthesis Of Cyclopentanoids And Cyclitol Derivatives Originated From Polychlorinated Norbornene Systems." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12611020/index.pdf.

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Optically active polychlorinated norbornene systems are important starting compounds for the synthesis of many complex molecules. The synthetic strategy of this study mainly depends upon the enzymatic resolution of hydroxymethyl-substituted polychlorinated norbornene structures. The enantiomerically enriched acetoxymethyl derivatives were synthesized in high ee values by several lipases. The absolute configuration of tetrachlorinated norbornene system was determined by X-ray analysis. The second part of the thesis involves the ruthenium and cerium-catalyzed oxidation reactions of various poly
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48

Tan, Duygu. "Silicon Tetrachloride Mediated Asymmetric Aldol Addition Reaction." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615396/index.pdf.

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Aldol addition reaction is one of the most important and most studied carbon-carbon bond forming reactions in organic chemistry. Recent studies focused on the catalytic version of this chemistry. Different from the classical Mukaiyama-type aldol reactions, chiral lewis bases have been used as promoters. In the presence of SiCl4, these reactions proceed through a cyclic transition state leading to anti aldol product as a major product with moderate-to-good diastereo and enantioselectivities. Phosphoramide derivatives, BINAPO, BINAPO derivatives, N,N-dioxides and N-oxides have been extensively u
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49

Guliyev, Ruslan. "Rational Design Of Ratiometric Chemosensor Via Modulation Of Energy Donor Efficiency." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12609889/index.pdf.

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Rational design of fluorescent chemosensors is an active area of supramolecular chemistry, photochemistry and photophysics. Ratiometric chemosensors are even more important, as they have an internal system for selfcalibration. In order to develop a new methodology for a ratiometric chemosensor design, we proposed coupling of energy transfer phenomenon to ion sensing. In this study, we targeted energy transfer cassette type chemosensors, where the efficiency of transfer is modulated on the donor side, by metal ion binding which changes the spectral overlap. This work involves the synthesis of a
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50

Altun, Yasemin. "Addition Of Carbonyl Compounds To The Cyclic Olefins: Synthesis Of Cyclitols." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12610117/index.pdf.

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ABSTRACT ADDITION OF CARBONYL COMPOUNDS TO THE CYCLIC OLEFINS: SYNTHESIS OF CYCLITOLS Altun, Yasemin M.S., Department of Chemistry Supervisor: Prof. Dr. Metin Balci October 2008, 160 pages Cyclitols have attracted a great deal of attention in recent years owing to biological activities exhibited by them and also their usefulness in the synthesis of other natural products and pharmaceuticals. Carbasugars are also a derivative of cyclitols and they are cyclic monosaccharide analogues which posses &amp<br>#8211<br>CH2OH group in their structure. In this study, novel synthetic strategies
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