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Relevant bibliographies by topics / Quadruplex binding proteins

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Academic literature on the topic 'Quadruplex binding proteins'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Quadruplex binding proteins"

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Brázda, Václav, Jiří Červeň, Martin Bartas, Nikol Mikysková, Jan Coufal, and Petr Pečinka. "The Amino Acid Composition of Quadruplex Binding Proteins Reveals a Shared Motif and Predicts New Potential Quadruplex Interactors." Molecules 23, no. 9 (2018): 2341. http://dx.doi.org/10.3390/molecules23092341.

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The importance of local DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, G-quadruplexes are perhaps the most well-characterized to date, and their presence has been demonstrated in many genomes, including that of humans. G-quadruplexes are selectively bound by many regulatory proteins. In this paper, we have analyzed the amino acid composition of all seventy-seven described G-quadruplex binding proteins of Homo sapiens. Our comparison with amino acid frequencies in all human proteins and specific protein subsets

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Volná, Adriana, Martin Bartas, Jakub Nezval, Vladimír Špunda, Petr Pečinka, and Jiří Červeň. "Searching for G-Quadruplex-Binding Proteins in Plants: New Insight into Possible G-Quadruplex Regulation." BioTech 10, no. 4 (2021): 20. http://dx.doi.org/10.3390/biotech10040020.

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G-quadruplexes are four-stranded nucleic acid structures occurring in the genomes of all living organisms and viruses. It is increasingly evident that these structures play important molecular roles; generally, by modulating gene expression and overall genome integrity. For a long period, G-quadruplexes have been studied specifically in the context of human promoters, telomeres, and associated diseases (cancers, neurological disorders). Several of the proteins for binding G-quadruplexes are known, providing promising targets for influencing G-quadruplex-related processes in organisms. Nonethel

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Heddi, Brahim, Vee Vee Cheong, Herry Martadinata, and Anh Tuân Phan. "Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide–quadruplex complex." Proceedings of the National Academy of Sciences 112, no. 31 (2015): 9608–13. http://dx.doi.org/10.1073/pnas.1422605112.

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Four-stranded nucleic acid structures called G-quadruplexes have been associated with important cellular processes, which should require G-quadruplex–protein interaction. However, the structural basis for specific G-quadruplex recognition by proteins has not been understood. The DEAH (Asp-Glu-Ala-His) box RNA helicase associated with AU-rich element (RHAU) (also named DHX36 or G4R1) specifically binds to and resolves parallel-stranded G-quadruplexes. Here we identified an 18-amino acid G-quadruplex-binding domain of RHAU and determined the structure of this peptide bound to a parallel DNA G-qu

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Sun, Zhi-Yin, Xiao-Na Wang, Sui-Qi Cheng, Xiao-Xuan Su, and Tian-Miao Ou. "Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction." Molecules 24, no. 3 (2019): 396. http://dx.doi.org/10.3390/molecules24030396.

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G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of genome. G-quadruplexes have been proved to be involved in the regulation of replication, DNA damage repair, and transcription and translation of oncogenes or other cancer-related genes. Therefore, targeting G-quadruplexes has become a novel promising anti-tumor strategy. Different kinds of small molecules targeting the G-quadruplexes have been designed, synthesized, and identified as potential anti-tumor agents, including molecules directly bind to the G-quadruplex and molecules interfering with the bin

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Wu, Guanhui, Luying Chen, Kristen Huseman, et al. "Abstract 2756: Custom G4 DNA microarray can determine large-scale binding selectivity of small molecules and proteins to oncogene G-quadruplexes." Cancer Research 83, no. 7_Supplement (2023): 2756. http://dx.doi.org/10.1158/1538-7445.am2023-2756.

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Abstract G-quadruplexes are novel DNA secondary structures that are formed in guanine-rich genomic regions with functional importance in cancers, such as human telomeres and oncogene promoters. G-quadruplexes adopt globular structures distinct from duplex B-DNA and their structural diversity suggests specific recognition. G-quadruplexes have become attractive drug targets because they provide a means of addressing otherwise undruggable targets. As one example, MYC is an important oncogene that is difficult to target by traditional drug design; however, its regulation involves a promoter G-quad

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Bhadane, Rajendra, Rupali Bhadane, and Dhananjay Meshram. "Insights of potential G-quadruplex sequences in telomeres and proto-oncogenes." Archive of Oncology 21, no. 3-4 (2013): 118–24. http://dx.doi.org/10.2298/aoo1304118b.

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Guanine rich sequences have the ability to fold into stable 4 stranded structures called G-quadruplex under physiological concentrations of Na+ or K+. G-quadruplexes are found in telomeres, being stable structures under the control of telomerase binding proteins. They are also identified throughout the genome and are enriched in promoter regions of protein coding genes, upstream and downstream of the transcription initiation sites. A number of these promoter quadruplexes have been investigated for several proto-oncogenes. The formation of these quadruplexes can lead to chemical intervention of

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Traczyk, Anna, Chong Wai Liew, David James Gill, and Daniela Rhodes. "Structural basis of G-quadruplex DNA recognition by the yeast telomeric protein Rap1." Nucleic Acids Research 48, no. 8 (2020): 4562–71. http://dx.doi.org/10.1093/nar/gkaa171.

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Abstract G-quadruplexes are four-stranded nucleic acid structures involved in multiple cellular pathways including DNA replication and telomere maintenance. Such structures are formed by G-rich DNA sequences typified by telomeric DNA repeats. Whilst there is evidence for proteins that bind and regulate G-quadruplex formation, the molecular basis for this remains poorly understood. The budding yeast telomeric protein Rap1, originally identified as a transcriptional regulator functioning by recognizing double-stranded DNA binding sites, was one of the first proteins to be discovered to also bind

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Brázda, Václav, Lucia Hároníková, Jack Liao, and Miroslav Fojta. "DNA and RNA Quadruplex-Binding Proteins." International Journal of Molecular Sciences 15, no. 10 (2014): 17493–517. http://dx.doi.org/10.3390/ijms151017493.

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Shu, Huiling, Rongxin Zhang, Ke Xiao, Jing Yang, and Xiao Sun. "G-Quadruplex-Binding Proteins: Promising Targets for Drug Design." Biomolecules 12, no. 5 (2022): 648. http://dx.doi.org/10.3390/biom12050648.

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G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with the potential to form G4s are abundant in regulatory regions of the genome including telomeres, promoters and 5′ non-coding regions, indicating they fulfill important genome regulatory functions. Generally, G4s perform various biological functions by interacting with proteins. In recent years, an increasing number of G-quadruplex-binding proteins have been identified with biochemical experiments. G4-binding proteins are involved in vital cellular processes such as telomere maintenance, DNA replication, gen

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Izumi, Hiroto, and Keiko Funa. "Telomere Function and the G-Quadruplex Formation are Regulated by hnRNP U." Cells 8, no. 5 (2019): 390. http://dx.doi.org/10.3390/cells8050390.

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We examine the role of the heterogenous ribonucleoprotein U (hnRNP U) as a G-quadruplex binding protein in human cell lines. Hypothesizing that hnRNP U is associated with telomeres, we investigate what other telomere-related functions it may have. Telomeric G-quadruplexes have been fully characterized in vitro, but until now no clear evidence of their function or in vivo interactions with proteins has been revealed in mammalian cells. Techniques used were immunoprecipitation, DNA pull-down, binding assay, and Western blots. We identified hnRNP U as a G-quadruplex binding protein. Immunoprecipi

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Dissertations / Theses on the topic "Quadruplex binding proteins"

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Ray, Sujay. "Interactions of DNA binding proteins with G-Quadruplex structures at the single molecule level." Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1415185457.

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Lee, Sang C., Jack Zhang, Josh Strom, et al. "G-Quadruplex in the NRF2 mRNA 5′ Untranslated Region Regulates De Novo NRF2 Protein Translation under Oxidative Stress." AMER SOC MICROBIOLOGY, 2017. http://hdl.handle.net/10150/622753.

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Inhibition of protein synthesis serves as a general measure of cellular consequences of chemical stress. A few proteins are translated selectively and influence cell fate. How these proteins can bypass the general control of translation remains unknown. We found that low to mild doses of oxidants induce de novo translation of the NRF2 protein. Here we demonstrate the presence of a G-quadruplex structure in the 5' untranslated region (UTR) of NRF2 mRNA, as measured by circular dichroism, nuclear magnetic resonance, and dimethylsulfate footprinting analyses. Such a structure is important for 5'-

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Tassinari, Martina. "G-quadruplexes in the HIV-1 LTR promoter: targeting and binding proteins." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3424965.

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G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that may form in G-rich sequences and regulate key biological processes. We have previously identified three mutually exclusive and functionally significant G4s in the unique long terminal repeat (LTR) promoter of the human immunodeficiency virus type 1 (HIV-1): their formation decreases viral transcription, with an effect that is enhanced by the presence of the cellular protein nucleolin and G4 ligands. Given that most available G4 binders display yet insufficient selectivity towards different G4s, we explored the possi

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Le, Bras Morgane. "Rôle des protéines de liaison à l'ARN hnRNP H et hnRNP F dans les régulations traductionnelles dans les glioblastomes." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30277.

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Le glioblastome multiforme (GBM) est une tumeur cérébrale extrêmement agressive associée à un mauvais pronostic. C'est pourquoi, il apparaît nécessaire d'identifier les mécanismes moléculaires participant au développement des GBM ainsi qu'à leurs résistances aux traitements afin de développer de nouvelles approches thérapeutiques. Récemment, il a été montré que les régulations traductionnelles jouent un rôle fondamental dans les propriétés agressives du GBM. Les protéines de liaison à l'ARN (RBP) sont des acteurs majeurs de ces régulations dont l'expression/activité est altérée dans les GBM. L

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Patel, Sachin Dinesh. "Studies on a designed G-quadruplex binding protein that inhibits human telomerase." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620939.

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Bourdon, Sebastien. "Régulation des ARN G-Quadruplexes par les protéines de liaison à l'ARN et leur interaction avec les N6-Méthyladénosines dans les cellules du cancer." Electronic Thesis or Diss., Université de Toulouse (2023-....), 2024. http://www.theses.fr/2024TLSES129.

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Le développement du cancer et la réponse aux traitements sont associés à des variations de la régulation post-transcriptionnelle qui entraîne une modification du protéome qualitativement et/ou quantitativement. La régulation post-transcriptionnelle implique des protéines de liaison à l’ARN (RBP), interagissant avec des éléments cis comme les séquences, les modifications ou les structures de l’ARN. Parmi ces éléments cis, les structures non-canoniques nommées ARN G-Quadruplexes (RG4), et les modifications N6-Méthyladénosines (m6A), jouent un rôle critique dans le modelage post-transcriptionnel

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Pipier, Angélique. "Etudes des G-quadruplexes : impact de la stabilisation par des ligands en tant qu'agents anti-cancéreux et identification des protéines associées régulant leur métabolisme." Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30118.

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Les G-quadruplexes (ou G4) sont des structures non canoniques des acides nucléiques formées à partir de séquences riches en guanines. Les G4 sont des structures stables, présentes sur l'ensemble du génome et qui peuvent adopter différentes conformations. La formation des G4 peut réguler, de façon positive ou négative, différents processus cellulaires tels que la transcription, la réplication, les transactions des ARN et les mécanismes mitochondriaux. L'ensemble de ces processus nécessite le recrutement de protéines capables de moduler la formation de ces structures. Certaines protéines, telles

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Jurisinec, Ashley. "Quadruplex stabilising Pt(II) complexes." Thesis, 2019. http://hdl.handle.net/1959.7/uws:57519.

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G-Quadruplex DNA (QDNA) motifs have been observed to form in various important regions of the human genome, contributing to cellular processes such as gene expression, DNA replication, and telomere maintenance. The relevance of these processes to cancer cell function and proliferation has drawn recent attention towards QDNA as a therapeutic target. This project contributes to the field by synthesising several heteroleptic platinum(II) complexes for the purpose of stabilising QDNA.A total of twelve novel heteroleptic complexes were synthesised, based on previously reported homoleptic bis-phenan

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Chen, Chien-Han, and 陳建漢. "Development of Credible Molecular Probes to Identify Pregnenolone-Binding Proteins and Site-Selectively Alkylate G-Quadruplex DNA." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/86330457034233765253.

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博士<br>國立臺灣大學<br>化學研究所<br>104<br>The work presented here consists of two parts: Section I describes that pregnenolone (P5) was equipped with benzophenone photoreactive group and biotin tag at C7 position in ether linkage to explore P5-binding proteins in the stage of embryonic development of the zebrafish. Various spacer lengths and orientations of P5-photoaffinity probes had been employed to investigate the influences on the activity of in vitro tubulin polymerization. With the preservation of the biological functions as P5, P5-NBPN was used to label P5-binding proteins from zebrafish embryo l

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Lin, Shiao-Han, and 林筱涵. "Ⅰ Synthesis and Application of Photoaffinity Probes : Identification of Pregnenolone Binding Proteins and Study of G-Quadruplex Helicase Ⅱ Synthesis of Telomere-Directed DNA Alkylating Agents Based on Prodrug Concept." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/85135478497642171722.

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碩士<br>國立臺灣大學<br>化學研究所<br>101<br>The development of proteomics has opened up new horizons for the research of many diseases and drugs invention. Meanwhile, the related technology of affinity-based probes (AfBPs) provides more direct evidence about the mediation and regulation of protein in physiological condition. The actions of AfBPs are mainly based on molecular recognition, with the introducing of photoreactive groups (PGs) to achieve the specific covalent modification on protein. With the directing of different substrate, allowing scientists for the corresponding binding protein studies to

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Book chapters on the topic "Quadruplex binding proteins"

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Simon, Philipp, Philipp Schult, and Katrin Paeschke. "Binding and Modulation of G-Quadruplex DNA and RNA Structures by Proteins." In Handbook of Chemical Biology of Nucleic Acids. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-9776-1_102.

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Simon, Philipp, Philipp Schult, and Katrin Paeschke. "Binding and Modulation of G-quadruplex DNA and RNA Structures by Proteins." In Handbook of Chemical Biology of Nucleic Acids. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-1313-5_102-1.

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Oyoshi, Takanori. "Characterization of G-Quadruplex DNA- and RNA-Binding Protein." In Long Noncoding RNAs. Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-55576-6_4.

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Lee, Chun-Ying, Christina McNerney, and Sua Myong. "G-Quadruplex and Protein Binding by Single-Molecule FRET Microscopy." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9666-7_18.

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Di Luzio, Francesco, Alessandro Paiardini, Federica Colonnese, Antonello Rosato, and Massimo Panella. "A Deep Neural Network for G-Quadruplexes Binding Proteins Classification." In Advances in Computational Intelligence. Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-43085-5_41.

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Kim, Min-Jeong, Pil Joong Chung, Tae-Ho Lee, Tae-Hoon Kim, Baek Hie Nahm, and Yeon-Ki Kim. "Convenient Determination of Protein-Binding DNA Sequences Using Quadruple 9-Mer-Based Microarray and DsRed-Monomer Fusion Protein." In Methods in Molecular Biology. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-292-2_4.

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McRae, Ewan K. S., David E. Davidson, and Sean A. McKenna. "2D Saturation Transfer Difference NMR for Determination of Protein Binding Sites on RNA Guanine Quadruplexes." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0680-3_9.

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Kharel, Prakash, and Pavel Ivanov. "Identification of bona fide RNA G-quadruplex binding proteins." In Methods in Enzymology. Elsevier, 2023. http://dx.doi.org/10.1016/bs.mie.2023.12.001.

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