Dissertations / Theses on the topic 'Quality materials'
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Postelnicu, Eveline. "Assessing materials quality for high efficiency electricity generation." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111327.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (pages 54-55).
Thermalization losses drastically reduce the efficiency of silicon solar cells. In an age where we need sustainable energy production more than ever, silicon is the best material to target due to its high stake in the sustainable energy market. An organic-inorganic solar cell hybrid of tetracene-covered silicon can reduce thermalization losses through the downconversion process of using a high energy photon to generate two lower energy electron-hole pairs. This occurs through the singlet-triplet fission process that excitons can undertake in tetracene. The effect of the interface quality between tetracene and silicon on successful triplet energy transfer is investigated. RFPCD (Radio Frequency Photoconductive Decay) is used to measure the bulk lifetime as well as the surface recombination lifetime of minority carriers in both n- and p-type Silicon of various doping concentrations. The surface recombination velocity was calculated from the measurement of surface recombination lifetime and analyzed after the silicon underwent RCA clean, RCA clean followed by an HF dip, tungsten nitride ALD, and tetracene evaporation using various combinations of these steps to form appropriate process flows. It was found that the highest surface quality was obtained by the lowest doped wafers. Additionally, similar doping levels were affected similarly by the various processing steps outlined above while the type of dopant did not seem to dictate the surface quality response. Triplet energy transfer was not fully confirmed from tetracene to silicon, but the surface quality turned out to be a very important indication for whether or not this energy transfer could occur.
by Eveline Postelnicu.
S.B.
Horkeby, Filip, and Melanie Larsson. "Quality Assurance of Pressure Equipment Materials and Steelwork." Thesis, Linköpings universitet, Kommunikations- och transportsystem, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-127336.
Full textQuitoriano, Nathaniel Joseph. "High-quality InP on GaAs." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/37370.
Full textIncludes bibliographical references (leaves 173-181).
In addition to traditional telecommunication applications, devices based on InP have received increased attention for high-performance electronics. InP growth on GaAs is motivated by the fact that InP wafers are smaller, more expensive, and utilize older fabrication equipment than GaAs. High-quality InP on GaAs may also serve as a step towards bringing high-quality InP onto the Si platform. Integrating high-quality InP onto bulk GaAs has proven to be challenging, however. While a number of commercial Molecular Beam Epitaxy (MBE) growth foundries offer InP on GaAs for M-HEMT (Metamorphic High-Electron-Mobility Transistor) applications, the successful demonstration of InP-based, minority-carrier devices on bulk GaAs remains elusive. In this work InP on GaAs suitable for minority carrier devices is demonstrated exhibiting a threading dislocation density of 1.2x1 06/cm2 determined by plan-view transmission electron microscopy. To further quantify the quality of this InP on GaAs, a photoluminescence (PL) structure was grown to compare the quality to bulk InP. Comparable room and low (20K) temperature PL was attained. (The intensity from the PL structure grown on the InP on GaAs was -70% of that on bulk InP at both temperatures.)
(cont.) To achieve this, graded buffers in the InGaAs, InGaP, InAlAs and InGaAlAs materials systems were explored. In each of these systems, under certain growth conditions, microscopic compositional inhomogeneities along the growth direction blocked dislocations leading to dislocation densities sometimes > 109/cm2. Using scanning-transmission electron microscopy, composition variations were observed. These composition variations are caused by surface-driven phase separation leading to Ga-rich regions. As the phase separation blocked dislocation glide and led to high threading dislocation densities, conditions for avoiding phase separation were explored and identified. Composition variations could be prevented in InxGal-,As graded buffers grown at 725 °C to yield low dislocation densities of 9x105/cm2 for x < 0.34, accommodating -70% of the lattice mismatch between GaAs and InP. However, further grading to 53% In is required to attain the lattice constant of InP. Compositional grading in the InyGal_yP (0.8 < y < 1.0) materials system was found to accommodate the remaining lattice mismatch with no rise in threading dislocation density by avoiding phase separation.
(cont.) Consequently, to achieve high-quality InP on GaAs a graded buffer in the InGaAs material system was followed by a graded buffer in the InGaP materials system to reach InP. The research to achieve high-quality InP on GaAs diverged into two paths. The first successful path, using graded buffers in different materials systems, was discussed above. The second path involved the deposition of InP at various temperatures on the high-quality Ino.34Gao.66As platform that was developed to determine if InP deposited on the InGaAs platform with 1.2% misfit relaxed controllably without much dislocation nucleation. To the contrary, rampant dislocation nucleation occurred in this highly-strained InP at all temperatures studied. Interestingly, however, the InP was observed to relax via a secondary-slip system, a/2<110>{1 10}. This secondary-slip system has a Burgers vector typical in semiconductors of a/2
(cont.) A critical stress, ec, appears to be required for dislocations to glide via the secondary-slip system otherwise all relaxation occurs by the primary-slip system. For e > ec and at all temperatures studied, both the primary- and secondary-slip systems are active with apparent cross-slip from one system to the other. At low temperatures, nearly all of the relaxation was accomplished through the secondary-slip system, however. The amount of relaxation via the primary- and secondary-slip systems at three different temperatures was quantified; the resulting Arrhenius plot suggests a difference in the activation energy for glide between the two systems is 1.5 eV.
by Nathaniel Joseph Quitoriano.
Ph.D.
Brice, Jeremy. "Pursuing quality wine in South Australia : materials, markets, valuations." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:f8ef1e0d-587e-4985-a088-9a1abdc24379.
Full textRamos, Irene. "Quality perception study in sustainable materials for Volvo Cars." Thesis, Jönköping University, JTH, Industridesign, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-53172.
Full textNewton, Claudia. "Towards sustainable luxury materials selection : measuring the perceived quality of automotive interior materials : innovation report." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/109972/.
Full textKenerson, Jonathan E. "Quality Assurance and Quality Control Methods for Resin Infusion." Fogler Library, University of Maine, 2010. http://www.library.umaine.edu/theses/pdf/KenersonJE2010.pdf.
Full textCerrato, Jose Manuel. "Impact of Piping Materials on Water Quality in Tegucigalpa, Honduras." Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/35030.
Full textMaster of Science
Gallagher, James C. "Synthesis and Investigation of High Quality Materials for Spintronics Applications." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1469141590.
Full textCooper, Mark J. "Evaluation of the quality and promotion of open learning materials." Thesis, Aston University, 1992. http://publications.aston.ac.uk/11930/.
Full textSears, Forest (Forest Orion). "3D print quality in the context of PLA color." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104320.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (page 45).
3D printing is a hot topic in manufacturing and a truly useful tool, but it has limitations. Print quality properties - like raft peelability, dimensional tolerance and surface roughness - are hard to calibrate perfectly. A common material used in fused deposition modeling (FDM) printers is polylactic acid (PLA). One print quality concern is how different colors of PLA print differently under the exact same settings. The inconsistency in print quality by color is bad for designers, students, and engineers who want to rapidly prototype effectively. Analyzing the thermal, chemical and mechanical properties of the different colors of PLA and relating it to the quality of the prints gives the user a chance to calibrate their machine effectively for higher quality prints. The quality of prints are quantified by scoring systems that measure three properties of a print: dimensional tolerance, how easily the raft peels from the print, and the surface roughness. The thermal properties of the different colors of PLA were analyzed using differential scanning calorimetry (DSC) up to 230° C. The integrals of peaks and troughs from the DSC - representing heat absorbed and released by the different colors of PLA - show that each color responds differently to thermal treatment. The mechanical strength of each color was found to be different through uniaxial tensile testing. Yellow and orange filament had high percent crystallinity at -12.1%, while having a high yield stress at 41-45 MPa, and a low yield strain at 6.6%-11% extension. Red and blue filament had low percent crystallinity at ~8.8-10.2%, while having a low yield stress at 33-36 MPa, and a high yield strain at 18%-23% extension. Additionally, Fourier transform infrared spectroscopy (FTIR) analysis determined each PLA color had unique additives. For calibrating printers for reliably high quality prints, crystallinity has a relationship with the amount of material extruded which could factor into qualities like dimensional tolerance and surface finish.
by Forest Sears.
S.B.
Miedl, Michaela. "The effect of raw materials and yeast quality on beer stability." Thesis, Heriot-Watt University, 2010. http://hdl.handle.net/10399/2620.
Full textHerzberg, Tina Sue. "The quality of brailled instructional materials produced in Texas public schools." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1789.
Full textHeim, Timothy Howard. "Impact of Polymeric Plumbing Materials on Drinking Water Quality and Aesthetics." Thesis, Virginia Tech, 2006. http://hdl.handle.net/10919/32260.
Full textThe use of polymer pipes is now very common in home plumbing and other parts of the drinking water distribution system. Many taste and odor complaints in drinking water are known to originate from contact of water with materials. The ability of polymer pipes used in home plumbing to affect drinking water quality and aesthetics was investigated using the Utility Quick Test (UQT). Analysis of water quality and aesthetics were conducted in the absence of disinfectant and the presence of either chlorine or chloramines. A Flavor Profile Analysis (FPA) panel was trained according to Standard Methods 2170B to evaluate the organoleptic characteristics of the samples. Laboratory analyses were performed to determine levels of total organic carbon (TOC), disinfectant residual, pH and to attempt to identify specific volatile organics.
The first part of this study investigated HDPE, cPVC and epoxy lined copper pipes using the UQT method. Both HDPE and epoxy-lined copper had significant effects on water quality and aesthetics during the approximately 10 day exposure of the UQT. HDPE and epoxy-lined copper leached significant amounts of TOC and consumed more disinfectant than controls, but in different amounts. cPVC was the most inert of the materials tested and had the least impact on water quality and did not contribute any significant odor. None of the pipes tested appeared to contribute trihalomethanes to drinking water, but further analysis revealed that the compounds may actually be generated and subsequently sorbed into pipe walls. These data show the effects of newly installed polymeric pipe materials and their potential to impact water quality in differing capacities.
The second part of this study compared the results of the UQT on HDPE, epoxy lined copper, cPVC, PEX-a and PEX-b with the goal of comparing and contrasting how five different polymeric plumbing materials can impact drinking water quality. Results demonstrated the short-term ability of all pipe materials except cPVC to impact water quality and aesthetics. This data could potentially be useful in generating selection criteria for homeowners and plumbing professionals regarding the impact of newly installed plumbing materials.
Master of Science
Sinno, Rami Assem 1964. "Quality assurance for the clinical ferromagnetic seeds project." Thesis, The University of Arizona, 1989. http://hdl.handle.net/10150/276967.
Full textZaklouta, Hadi. "Cost of quality tradeoffs in manufacturing process and inspection strategy selection." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/76133.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (p. 106-108).
In today's highly competitive markets manufacturers must provide high quality products to survive. Manufacturers can achieve higher levels of quality by changing their manufacturing process and/or by product inspection where a multitude of different strategies are often available. Each option has its own cost implications that must also be taken into account. By reconciling the competing objectives of quality maximization and cost minimization, a cost of quality approach serves as a useful framework for comparing available manufacturing process and inspection alternatives. Still, any rigorous comparison requires both a metric as well as a profound understanding of cost of quality tradeoffs. The cost of quality tradeoffs in manufacturing process and inspection strategy selection are examined through a probabilistic cost of quality model explored analytically using a sample set of fundamental inspection strategies (reinspect rejects, reinspect accepts and single inspection) and applied to the case of electric vehicle battery pack assembly. From an expected value point of view a series of parametric sensitivity analyses reveal that complex tradeoffs between manufacturing process, inspection, internal and external failure costs determine the optimal manufacturing process and inspection strategy combination. In general, reinspect rejects minimizes internal failure costs, reinspect accepts minimizes external failure costs and single inspection lies in between while minimizing inspection costs. This thesis illustrates the fact that results are scenario specific and depend on product cost-, manufacturing process and available inspection method attributes. It is also observed that manufacturing process improvement often coincides with a need to change inspection strategy choice, thereby indicating that manufacturing process and inspection strategy selection should not be performed independently of each other. This thesis demonstrates that the traditional expected value approach for evaluating cost of quality implications of manufacturing and inspection is often misleading. Decision tree formulations and discrete event simulations indicate that cost of quality distributions are asymmetric. High internal- and external failure costs, manufacturing process non-conformance rates and inspection method error rates are contributing factors. The alternative metric of expected utility captures decision makers risk aversion to high cost outliers and changes the criteria for optimality and favors inspection strategies and manufacturing processes that minimize external failure events with increasing risk intolerance. In the examined case of electric vehicle battery pack assembly both material- and external failure costs are very high. Analytical and discrete event simulation results indicate that for the given welding process the inspection strategy that minimizes external failure costs is optimal from an expected cost point of view as well as at high degrees of risk aversion. This result is shown to be sensitive to parameters driving the cost and probability of external failure events.
by Hadi Zaklouta.
S.M.
Falch, Eva. "Lipids from residual fish raw materials : Quality assessment by advanced analytical methods." Doctoral thesis, Norwegian University of Science and Technology, Department of Biotechnology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-2263.
Full textGaete-Martinez, Victor. "Optical Measurement of Strang Geometry and Orientation and Their Influence on Oriented Strand Composite Formation Quality." Fogler Library, University of Maine, 2009. http://www.library.umaine.edu/theses/theses.asp?highlight=1&Cmd=abstract&ID=FTY2009-004.
Full textSlagter, Alejandra. "Advanced Inspection of Surface Quality in Continuously Cast Products by Online Monitoring." Thesis, Luleå tekniska universitet, Institutionen för teknikvetenskap och matematik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-70634.
Full textMaher, Tabitha V. "An air quality study of nanomaterials in a manufacturing setting." abstract and full text PDF (free order & download UNR users only), 2006. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1442102.
Full textZhang, Jinsong 1975. "Modeling VOC sorption of building materials and its impact on indoor air quality." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/71107.
Full textIncludes bibliographical references (p. 158-162).
Sorption of volatile organic compounds (VOCs) by building materials can have significant effect on the indoor VOC concentration levels and indoor air quality in buildings. The objective of this study was to investigate experimentally the effects of environmental conditions (temperature, humidity and air velocity) on the sorption rate and capacity of three typical types of building materials (carpet, ceiling tile and painted drywall), and to evaluate existing sorption models with experimental data. A small-scale chamber test system has been developed in this study to conduct sorption tests under different environmental conditions. The sorption data collected were analyzed by three different analysis methods: the integration method, the linear Langmuir model method and the diffusion model method. The results of the integration method indicated that for the painted drywall, the differences among different environmental conditions were so small compared with the experimental uncertainties that no statistically significant environmental effect could be observed at 95% confidence level. The sorption of VOCs on ceiling tile decreased with the increase of the air velocity and temperature, but did not change significantly with the relative humidity. The sink strength of benzaldehyde under high humidity was much stronger than any other conditions. The sorption of VOCs on carpet appeared to be a diffusion-controlled process. With the increase of temperature, the diffusion coefficient increased while the partition coefficient decreased. A higher air velocity increased the sink capacity of dodecane on carpet. The relative humidity had no significant effect on the sorption of VOCs on carpet. Based on the model evaluation conducted in this study, the linear Langmuir model appeared to be suitable for painted drywall and ceiling tile while the diffusion model is more suitable for carpet.
by Jinsong Zhang.
S.M.
Grönlund, Ulla. "Quality improvements in forest products industry : classification of biological materials with inherent variations." Doctoral thesis, Luleå, 1995. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-16899.
Full textGodkänd; 1995; 20070428 (ysko)
Freemantle, Richard James. "Ultrasonic compression wave evaluation of adhered metal sheets and thin sheet materials." Thesis, Keele University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282635.
Full textSamavedam, Srikanth B. (Srikanth Balaji) 1970. "Growth and characterization of high quality relaxed graded silicon germanium layers for integrated photodetectors." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/9586.
Full textIncludes bibliographical references (leaves 137-147).
Silicon germanium layers on silicon substrates (SiGe/Si) are useful for a variety of microelectronics applications. The most successful technique for growing low defect density relaxed SiGe/Si layers is relaxed compositional grading. However, with increasing Ge content in the graded SiGe layers, the following materials concerns need to be addressed-{i) a high surface roughness, (ii) the formation of dislocation pile-ups, (iii) an increase in the threading dislocation density, (iv) tensile strains and micro-cracking due to thermal mismatch, and (v) particulate contamination from germane gas phase nucleation. We have grown relaxed graded SiGe/Si layers using ultra-high vacuum chemical vapor deposition (UHVCVD) at growth temperatures ranging between 500°-900° C and pressures between 30-500 millitorr. The SiGe growth rates at different temperature and Ge content regimes agree with previously proposed theories. By applying both a dislocation blocking criterion and surface roughness effects to graded SiGe/Si structures, we have proposed a model to explain and predict the formation of dislocation pile-ups in graded structures. We have discovered that there is a substantial improvement in the surface roughness and dislocation pile-up density in graded SiGe layers by growing on miscut Si(00l) substrates. It was found that the array of 60° dislocations that usually forms to relieve the misfit stress could transform into a novel lower energy hexagonal dislocation network consisting of all edge dislocations. High resolution X-ray diffraction measurements indicate that there is a decrease in the rate of epilayer tilting in the Ge-rich layers of the graded buffer in agreement with the observed dislocation structure. We have designed an optimized relaxed buffer (ORB) process that allows us to grow high quality Ge layers on Si substrates. By employing a chemical mechanical polishing (CMP) and regrowth step within the epitaxial structure, we have minimized the formation of dislocation pile-ups. Compressive strain has been incorporated into the graded layers to overcome the thermal mismatch problem. The ORB process eliminates dislocation pile-ups, decreases gas-phase nucleation of particles, and eliminates the increase in threading dislocation density. Germanium p-n photodiodes were fabricated to assess the diectronic quality and prove the feasibility of a high quality infrared detector on a Si substrate. The dark current in the diodes was at least two orders of magnitude lower than any previously reported value for Ge photodiodes on Si substrates. Capacitance measurements indicate that the devices are capable of high speed operation. Dislocation filtering experiments were conducted to reduce threading dislocation densities on pattered mesas. It was found that at the strain levels from small compressive mismatch, dislocation nucleation from the mesa edges dominates over dislocation filtering.
by Srikanth B. Samavedam.
Ph.D.
Azari, Dorcheh Kamran. "Investigation of the materials and paste relationships to improve forming process and anode quality." Thesis, Université Laval, 2013. http://www.theses.ulaval.ca/2013/30365/30365.pdf.
Full textKerr, Amanda. "Evaluation and analysis of quality of life picture test materials for persons with dementia." Connect to resource, 2009. http://hdl.handle.net/1811/37274.
Full textGhasemzadeh-Barvarz, Massoud. "Quality control of complex polymer materials using hyperspectral imaging associated with multivariate statistical analysis." Doctoral thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/26025.
Full textIn the first step of this work, maleic anhydride grafted polyethylene (MAPE)/hemp fiber composites with different filler concentration between 0 to 60% were analyzed by NIR imaging. Three chemometrics methods including Partial Least Squares (PLS), Multivariate Curve Resolution (MCR) and Multivariate Image Analysis/Multivariate Image Regression (MIA/MIR) were implemented and compared for predicting mechanical properties as well as mapping chemical compositions and material physical variations. In the second part of this project, a series of complex multilayer films (industrial samples) were investigated using NIR hyperspectral imaging and Multivariate Image Analysis (MIA). The potential and effectiveness of the proposed method for detecting defects caused by missing layer(s) were studied for unprinted and printed films. In the final part, polypropylene (PP)/glass/flax hybrid composites were studied. The effect of composition (fiber content between 0 and 40 vol%), as well as water, thermal and UV aging on mechanical properties was investigated. Then, Scanning Electron Microscopy (SEM) images of unaged hybrid composites were analyzed using texture analysis and multivariate methods. Finally, NIR imaging was implemented on unaged and aged composites to predict their final properties as well as to capture chemical composition and aging variations. In summary, the results show that combining hyperspectral imaging and multivariate statistical methods is a powerful tool for quality control of complex polymer composites. Since the proposed method is rapid and nondestructive, one can implement it for on-line quality control of finished plastic products. On the other hand, texture analysis and multivariate methods can be applied for quantifying the mixing aspects of composites.
Elliott, Lewis Roland. "Physical activity in natural environments : importance of environmental quality, landscape type and promotional materials." Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/22411.
Full textKim, Andrew Y. (Andrew Youngkyu) 1973. "Co-evolution of microstructure and dislocation dynamics in InGaP/GaP : engineering high quality epitaxial transparent substrates." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/9031.
Full textIncludes bibliographical references (p. 253-261).
Graded buffers oflnxGa1-xP on GaP ([Delta]x[lnxGa1-x]P/GaP) can be used to fabricate potentially high performance, epitaxial transparent substrates light-emitting diodes (ETSLEDs ). Practical devices have thus far been limited by poor quality: reports of [Delta]x[lnxGa1-x]P/GaP show sharp declines in device and material quality above x - 0.3. This study revisits the challenge of engineering high-quality [Delta]x[lnxGa1-x]P/GaP grown by metal-organic vapor phase epitaxy. A new planar defect microstructure oriented 10-15° off the (1-10), which we call branch defects, was discovered via transmission electron microscopy. Branch defects feature sharp strain fields and dominate the microstructure. causing dislocation pinning and escalation. Branch defects occur later in growth with increasing temperature; however, they are stronger when formed at higher temperatures. Branch defects do not appear to be directly related to other co-existing microstructures in lnxGa1.xP. In the phase space where branch defects are absent, the intrinsic dislocation dynamics of[Delta]x[lnxGa1-x]P/GaP were explored. Dislocation density decreases exponentially with increasing temperature, supporting a kinetic glide model for graded buffers. Dislocation glide velocities also appear to increase dramatically while grading from GaP to InP. Optimizing the co-evolution of dislocation dynamics and branch defects has achieved dislocation densities of [Delta]x106 cm-2 out to x = 0.54, the highest quality [Delta]x[lnxGa1-x]P/GaP reported to date. Reciprocal space mapping reveals three distinct regimes of crystallographic tilt. Qualitative to semi-quantitative models were developed for each regime to elucidate the changing dislocation dynamics during V x[lnxGai-x]P/GaP growth. Critical reanalysis of earlier reports provides further evidence for the kinetic glide model. Overall, discovery of tilt regimes demonstrates the need for a dynamic approach to tilt analysis. A series of ETS-LEDs with emission wavelengths ranging from 575 to 655 nm was fabricated from optimized [Delta]x[lnxGa1-x]P/GaP and shows continuing good performance for [Delta]x 0.3, in contrast to earlier reports. A second, subtle process optimization to better suppress branch defects increases efficiency 60% and drops spectral width 8 meV. Since self-absorption in [Delta]x [lnxGai-x]P/G
by Andrew Y. Kim.
Ph.D.
Dias, André Luís. "Quality by design e gerenciamento de riscos como estratégias para a construção de um modelo regulatório para medicamentos de base nanotecnológica /." Araraquara, 2017. http://hdl.handle.net/11449/150926.
Full textBanca: Pedro Canísio Binsfeld
Banca: Marco Vinícius Chaud
Banca: Marlus Chorilli
Banca: Beatriz Stringhetti Ferreira Cury
Resumo: A nanotecnologia tem evoluído rapidamente em diversas áreas, incluindo na área farmacêutica. Para produtos sujeitos à regulação sanitária, em especial medicamentos, esta evolução é um desafio regulatório. Embora já existam medicamentos base nanotecnológica disponíveis no mercado, existem importantes lacunas regulatórias que precisam ser preenchidas. Assim, frente à importância e ao impacto deste tema, foi realizada uma pesquisa científica-regulatória de modo a propor bases para a construção de um arcabouço regulatório, em especial para a regulação de medicamentos de base nanotecnológica. Ficou evidente que não existe, a nível mundial, diretrizes únicas para este tipo de regulação, iniciando pela ausência de consenso no conceito de "nanomaterial". Percebe-se como consenso internacional que a complexidade e diversidade que cerca os nanomateriais exigem abordagens diferenciadas daquelas empregadas em produtos tradicionais, requerendo avaliações caso a caso e abordagens para avaliar os novos riscos introduzidos. Dessa forma, este trabalho avaliou as metodologias Quality by Design (QbD) e Gerenciamento de Riscos como alternativas para a construção do modelo regulatório. QbD e Gerenciamento de Riscos facilitam, compilam, direcionam e sistematizam o conhecimento e assim, por meio do desenvolvimento de produtos robustos, seguindo as etapas previstas no QbD, inclusive com a construção e sedimentação do Perfil de Qualidade Alvo do Produto e de Atributos Críticos a Qualidade, constituem... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Nanotechnology has evolved rapidly in diverse areas, which include the pharmaceutical field. For products subject to sanitary regulation, especially drugs, this evolution is a regulatory challenge. Although there are nanotechnological drugs available in the market, there are important regulatory gaps that must be completed. Thus, in view of the importance and impact of the object, a scientific-regulatory research was carried out in order to propose bases for a regulatory framework, particularly for a regulation of nanotechnological drugs. It became clear that there is no a worldwide guidance for this type of regulation, starting with the lack of consensus for the concept of "nanomaterial". It has been noticed as an international consensus that the complexity and diversity surrounding nanomaterials require different approaches from those used in traditional products, demanding case-by-case evaluation and approaches to assess new introduced risks. Thus, this work evaluated Quality by Design (QbD) and Risk Management methodologies as alternatives for the construction of the regulatory model. QbD and Risk Management facilitate, compile, direct and systematize knowledge and thus, through a robust product development, following as expected by QbD steps - including a construction and sedimentation of the Product Target Quality Profile and Critical Quality Attributes - become important tools for building quality in nanotechnology-based drugs. Risk Management, especially the risk anal... (Complete abstract click electronic access below)
Doutor
Copeland, Natalie Suzanne. "Evaluating a wood-strand material for wind erosion control and air quality protection." Online access for everyone, 2007. http://www.dissertations.wsu.edu/Thesis/Fall2007/n_copeland_113007.pdf.
Full textAl-Nakeeb, Ahmed A. R. "An assessment of the effectiveness of Quality Assurance Systems in the construction industry." Thesis, University of South Wales, 2000. https://pure.southwales.ac.uk/en/studentthesis/an-assessment-of-the-effectiveness-of-quality-assurance-systems-in-the-construction-industry(bb4ec2f0-37e6-46dc-85e6-3945cfc1da57).html.
Full textAl-khedher, Mohammad Abdelfatah. "Carbon nanotubes characterization and quality analysis using artificial intelligence." Online access for everyone, 2007. http://www.dissertations.wsu.edu/Dissertations/Spring2007/m_al-khedher_041907.pdf.
Full textKarunaratne, Malintha P. Angelo. "Analysis of alterations in matrix quality at nanoscale in metabolic bone diseases using synchrotron X-ray diffraction." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8490.
Full textDurand, Monique Lucia. "Disinfectants and Plumbing Materials: Effects on the Sensory and Chemical Characteristics of Drinking Water." Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/35861.
Full textMaster of Science
Simington, Maureen Fresquez 1970. "Redefining manufacturing quality control in the electronics industry." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/34709.
Full textAlso available online at the MIT Theses Online homepage
Includes bibliographical references (p. 103).
The most time consuming and capital intensive portion in the assembly of power electronic devices is the test system. A comprehensive test system including functional and stress screening technologies can significantly increase assembly times and more than double the capital investment required in a new assembly line. The primary purpose of the test system is to screen components for early life failures and to verify proper assembly. Determination of key performance characteristics and the resultant test system are developed during the product design phase and are seldom revised after the product has been released to manufacturing. This thesis explores best practices in testing methods and develops new methods to analyze test system performance. Both efforts were conducted in an effort to optimize existing test regimes. Upon completion of the above analyses the existing test sequence was reduced by 50%. This was primarily due to a discovery in the Burn In test cycle which indicated that failures correlated strongly with the on/off cycles inherent in the test sequence. A new test cycle was proposed to accommodate this finding and test results verified the initial hypothesis. Additionally, the summary of best practices identified new forms of product testing including Highly Accelerated Stress Testing (HAST), moving additional product testing into the development phase consequently reducing testing requirements during assembly.
by Maureen Fresquez Simington.
S.M.
Eriksson, Conny. "Roll pass design for improved flexibility and quality in wire rod rolling." Doctoral thesis, KTH, Production Engineering, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-53.
Full textThe thesis treats roll pass design in wire rod rolling of stainless steel for sequences and series built up by two-symmetrical grooves. It is focused on predicting rolling flexibility, also called working range, as well as product quality. For analysing the flexibility a computer program has been developed. The minimum and maximum roll gap and corresponding bar areas for series of grooves including "oval", "round", "false round", "square" and "diamond" shapes are calculated. Six pass designs used in Swedish mills are analysed. Full-scale rolling is compared with laboratory experiments for the square-oval and false round (round)-oval series. The false round-oval series offers the largest working range and that the flexibility is smaller for pass sequences designed for high reductions. The false round-oval series are also acknowledged as a series for high quality steels and are usually better than the square-oval series having a tendency for defect formation. The thesis also includes high-speed rolling of wire rod in blocks. Here interstand tensions are utilised in order to keep the process stable. For obtaining the required dimensional tolerances of the product they are kept as low as possible. However interstand tensions could be used in order to increase the working range and move the product range towards smaller wire cross sections. For analysing this possibility, a narrow spread technology is utilised. At present time a practical problem is referred to the fixed gearings in the common blocks, which require a certain and given level of interstand tensions and corresponding reductions. This problem can however be solved by means of new block design and modern process control technology. Roll stands can be separately driven and controlled at very high speeds. Thus the eight stand blocks can be subdivided into four plus four passes blocks with a cooling line between enabling also higher productivity without violating the product quality because defect formations caused by a too high rolling temperature. The true working range of a series for a specific steel grade is however not only dependent on the possible spectrum of wire dimensions that can be obtained but might also depend on its ability to decrease or eliminate defects such as surface cracks. Thus, the behaviour of artificial V-shaped cracks in the longitudinal direction has been investigated and compared for the square-oval and false round (round)-oval series mentioned above. In agreement with other research works it was established that efficient rolling conditions for reducing the cracks are obtained when the cracks open up at the same time as their depth is reduced. If the V-shaped crack is closed by contact between its oxidized side surfaces the rolling schedule is not optimal for getting a high quality product. A deeper understanding of the experimental results was obtained by means of an FE-analysis
Choi, Ki-Seok. "Service level guarantee in capacitated supply chains." Diss., Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/25583.
Full textMampshe, Mashao Frank. "The experiences of senior educators in the quality assurance of head of departments' teaching materials." Diss., University of Pretoria, 2015. http://hdl.handle.net/2263/52946.
Full textDissertation (MEd)--University of Pretoria, 2015.
Education Management and Policy Studies
MEd
Andersson-Wikström, Alexandra. "Potential Sources of Stormwater Pollutants : Leaching of Metals and Organic Compounds from Roofing Materials." Thesis, Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-46864.
Full textValiderat; 20150715 (global_studentproject_submitter)
Namkoong, Gon. "Molecular beam epitaxy grown III-nitride materials for high-power and high-temperture applications : impact of nucleation kinetics on material and device structure quality." Diss., Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/16426.
Full textAustin, Michael. "An investigation of the processing and reconstruction conditions necessary to optimize the transmissin hologram images formed using conventinal silver halide materials." Thesis, University of Westminster, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.237408.
Full textRobinson, Daniel J. "A Delphi study to examine the quality measurement standards by online instructors using the Quality Matters Rubric as a basis for creating instructional materials." Kent State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=kent1491431111417877.
Full textBevin, Emma, and Matilda Björklund. "Sample quality effects of laser cutting : An empirical study on the heat affected zone and the surface quality in laser cut samples." Thesis, KTH, Materialvetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-277878.
Full textDenna studie har utförts i syfte att undersöka utsträckningen av den värmepåverkade zonen för att kunna använda laserskärning för att skära prover till dragprovning. Ett problem med laserskärning är att metaller absorberar värmeenergin, vilket orsakar förändringar i mikrostrukturen. Denna värmepåverkade zon bör minimeras och avlägsnas från metallen, då det minskar kvalitén på proverna samt på dragprovningen. I denna studie har två material undersökts, det höghållfasta stålet Docol 1000DP och det duplexa rostfria stålet LDX 2101. Stålen skars ut i form av hundben för dragprovning med två olika effekter på lasern 2500 W och 3500 W. Proverna skars ut med olika skärhastigheter, började med lägre hastigheter och ökade sedan tills lasern inte längre kunde skära igenom materialet. Därefter undersöktes både den värmepåverkade zonen och kvaliteten på skärytan. Resultaten från denna studie visade att den värmepåverkade zonen minskar med ökad skärhastighet. Vid skärning i Docol 1000DP med höga skärhastigheter räcker det att avlägsna 0,30 mm för att ta bort den värmepåverkade zonen med marginal. Ingen skillnad i värmepåverkad zon observerades mellan proverna skurna med 2500 W och 3500 W vid skärning med högsta skärhastigheten för varje lasereffekt. Den värmepåverkade zonen i LDX 2101 var mycket liten, i storleksordningen 50 μm, vilket gjorde den svårt att mäta. Slutsatsen gav att det är tillräckligt att avlägsna 0,15 mm för att avlägsna den värmepåverkade zonen med marginal. Ingen skillnad kunde observeras mellan proverna skurna med en lasereffekt på 2500 W eller 3500 W. Gemensamt för båda materialen var att gradbildningen minskade med ökad skärhastighet.
Bäck, Frida. "Influence of bio-coal ash respectively coal structure on coke production and coke quality." Thesis, Luleå tekniska universitet, Industriell miljö- och processteknik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-76180.
Full textWallach, Jeremy C. (Jeremy Cole) 1975. "Solving a corrosion quality problem at a major US automaker." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/34756.
Full textIncludes bibliographical references (leaves 55-56).
This project addresses a corrosion quality problem at an automaker. The problem, hem flange corrosion, involves the appearance of red rust along edges of closure panels (doors, hoods, deck lids, etc) after three to four years in service. This project focuses on finding a solution for a particular new model. The project contains two parts: a technical treatment of hem flange corrosion and an organizational analysis. The technical discussion includes a root-cause analysis, failure analysis of past solution attempts, benefit/cost analysis of potential solutions, and technical recommendations. The organizational discussion examines why this automaker was challenged with implementing a solution.
by Jeremy C. Wallach.
S.M.
M.B.A.
Baliso, Unathi. "Partnering with suppliers for quality improvement." Thesis, Cape Peninsula University of Technology, 2010. http://hdl.handle.net/20.500.11838/1232.
Full textUneven surfaces on national roads that often lead to difficulty and even danger can be extremely hazardous when wet, due to mud and cracks, and also create dust pollution for motorists, pedestrians, residents and business. The continuing use of low quality raw materials in producing hot mix asphalt for national roads, leads to regular maintenance at a very high cost. The quality aggregates (stone that is used to produce asphalt), and the quality of bitumen are often inadequate for the correct composition of hot mix asphalt. The mst important factors affecting initial and long term performance of the highways is the inferior pavement structure and condition, due to poor aggregates (raw material)from suppliers. The performance of asphalt i s largely determined by the characteristics of its constituents, the asphalt binder and aggregates.
Hansson, Peter. "The Sink-Effect in Indoor Materials : Mathematical Modelling and Experimental Studies." Doctoral thesis, KTH, Civil and Architectural Engineering, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3619.
Full textIn this thesis the sink-effect in indoor materials wasstudied using mathematical modelling and experimental studies.The sink-effect is a concept which is commonly used tocharacterise the ability of different indoor materials to sorbcontaminants present in the indoor air. The sorption process ismore or less reversible, i.e. molecules sorbed in materials athigh contaminant concentrations may again be desorbed at lowerconcentrations. Knowledge of the sorption capacity of materialsand the rate at which sorption and desorption takes place is offundamental importance for mathematical simulation of indoorair quality. The aim of this work is to contribute withknowledge about how the sink-effect can be described inmathematical terms and how the interaction parametersdescribing the sorption capacity and sorption/desorptionkinetics can be determined. The work has been of amethodological nature. The procedure has been to set upphysically sound mathematical models of varying complexity andto develop small-scale chamber experiments. Two differentdynamic chamber methods have been used. One is based on amodified standard FLEC-chamber while the other uses a chamberwith two compartments, one on each side of the material. The"twin-compartment" method was designed due to the observationthat the contaminant readily permeated straight through theselected materials, which resulted in uncontrolled radiallosses in the FLEC-chamber. In order to be useful forcomparison between experiments and calculations and parameterfitting, the boundary conditions in the chambers must beprecisely known and controlled. This matter has shown to be themost crucial and difficult problem in the research. A varietyof mathematical models for the sink-effect have been proposed.In some models advanced fluid simulations were used in order totest the influence ofill-defined flow boundary conditions. Theaim of the modelling is to find a formulation with a minimum ofinteraction parameters, which is generally useful, i.e. both insmall-scale laboratory environments and in full-scale like anoffice room. Estimated model parameters are shown to be able toyield a reasonably good fit to experimental data for thesorption process but a less satisfactory fit for the desorptionprocess.
Keywords:sink-effect, sorption, adsorption, diffusion,indoor air quality, volatile organic compounds, VOC,contaminants, building materials
Afonso, João Tomás Felgueiras Gomes. "Quality Control in additive Manufacturing - Capacity Assessment of non-touching methods." Dissertação, 2017. https://hdl.handle.net/10216/105957.
Full textAfonso, João Tomás Felgueiras Gomes. "Quality Control in additive Manufacturing - Capacity Assessment of non-touching methods." Master's thesis, 2017. https://hdl.handle.net/10216/105957.
Full text