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Journal articles on the topic 'Quasi emulsion solvent diffusion method'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Tyagi, Gajendra, and Suresh Choudhary. "Preparation of flutrimazole micro sponge gel by quasi-emulsion solvent diffusion method." Asian Journal of Pharmaceutical Research and Development 12, no. 3 (2024): 43–49. http://dx.doi.org/10.22270/ajprd.v11i3.1393.

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Microsponge containing Flutrimazole drug with six different proportions of Eudragit RS 100 as polymer were obtained successfully using quasi-emulsion solvent diffusion method. Particle size and physical properties of the formulations were examined. Physical properties showed that microsponge formulations MS IV and MS VI exhibited better material efficiency and yield. Two microsponge formulations were prepared as gels in 0.35% w/w carbomer and examined for pH, viscosity, permeability, drug content, in vitro release, antibacterial activity, and in vivo antifungal activity on Rabbit skin. The vis

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2

Maghsoodi, Maryam, and Ali Nokhodchi. "Agglomeration of Celecoxib by Quasi Emulsion Solvent Diffusion Method: Effect of Stabilizer." Advanced Pharmaceutical Bulletin 6, no. 4 (2016): 607–16. http://dx.doi.org/10.15171/apb.2016.075.

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3

Thenge, R. R., M. P. Chandak, and V. S. Adhao. "Spherical Crystallization: A Tool to Improve the Physicochemical Properties of APIs." Asian Journal of Pharmaceutical Research and Development 8, no. 3 (2020): 104–10. http://dx.doi.org/10.22270/ajprd.v8i3.727.

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A greater challenge in solid dosage formulation is the development of spherical agglomerates which increases the solubility and bioavailability of the drug. Spherical crystallization is “An agglomeration process that transforms crystals directly into compact spherical forms during the crystallization process.” Spherical crystallization is the novel agglomeration technique that can transform directly the fine crystals produced in the crystallization process into a spherical shape. Direct Compression of powders is simple and easy way of making tablets. In direct compression of Good Compressibili

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Maghsoodi, Maryam, and Ali Nokhodchi. "Agglomeration of celecoxib by quasi-emulsion solvent diffusion method without stabilizer: effect of good solvent." Pharmaceutical Development and Technology 23, no. 10 (2017): 1037–46. http://dx.doi.org/10.1080/10837450.2016.1270965.

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5

Gaurav, Magar Dr. A. V. Chandewar Dr. M. A. Channawar Satyam Pendor Ashwini Warankar. "Studies On Various Techniques Used for Masking the Bitterness of Drug and Formulation Development." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3223–38. https://doi.org/10.5281/zenodo.15464093.

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The aim of the study was to mask the bitterness of Valsartan by various taste masking techniques. Quasi- emulsion solvent diffusion method, Inclusion complexation and spray drying these methods were used. Eudragit RS 100 and Ethyl Cellulose were used in 1:1, 1:1.5 and 1:2 ratios to create taste masked microsponges using Quasi- emulsion solvent diffusion method. Kneading method was used to formulate Inclusion complexes. β- Cyclodextrin was used as complexing agent. Various ratios of drug and β- Cyclodextrin were tried for taste masking.  Spray drying method was attempted to make

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Sujathan, Ponni, and Umesh Kumar Sharma. "Development and Characterization of Metronidazole Loaded Microsponges for the Management of Diabetic Foot." International Journal of Research and Review 8, no. 10 (2021): 440–57. http://dx.doi.org/10.52403/ijrr.20211059.

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The objective of present work was formulation and evaluation of Metronidazole loaded microsponges for the management of diabetic foot ulcer via topical application and to reduce side effects. The microsponges were prepared by quasi-emulsion solvent diffusion method using different concentrations of Ethyl cellulose and Poly vinyl alcohol. The prepared microsponges were evaluated for particle size analysis, SEM, % production yield, % drug entrapment efficiency, in-vitro drug release studies, DSC and antimicrobial studies. FTIR studies shown that there was no interaction between drug and polymers

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7

Shinde, Jitendra, Rakesh Patel, and Shweta Shriwas. "Formulation and Evaluation of Topical Microsponge Based Gel of Clotrimazole." International Journal of Membrane Science and Technology 10, no. 2 (2023): 2538–48. http://dx.doi.org/10.15379/ijmst.v10i2.2905.

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The study's overarching goal is to develop a novel medication delivery method based on microsponge gel containing clotrimazole. Clotrimazole is poorly absorbed from the gastrointestinal tract (GIT), has a short half-life of only 2 h, & is metabolized into inert molecules by the liver. Therefore, clotrimazole's drug delivery method must be modified for topical application. Microsponge delivery is a novel approach to sustained drug release. Microsponges were made with a polymer solution of Eudragit RS 100 in dichloromethane (DCM) and ethanol (1:1) using a quasi-emulsion solvent diffusion tec

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8

A. Nief, Roaa, and Ahmed A. Hussein. "Preparation and Evaluation of Meloxicam Microsponges as Transdermal Delivery System." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 23, no. 2 (2017): 62–74. http://dx.doi.org/10.31351/vol23iss2pp62-74.

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The aim of present study was to develop gel formulation of microsponges of poorly soluble drug meloxicam (MLX) in order to enhance the release and dissolution of MLX which is the limitation for preparation in topical forms. Also skin delivery is an alternative administration for MLX that can minimize gastrointestinal (GI) side effects and improve patient compliance. The microsponges of MLX were prepared by quasi-emulsion solvent diffusion method. The effects of drug:polymer ratio, stirring time and Eudragit polymer type on the physical characteristics of microsponges were investigated and char

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9

Budarapu, Divya, U. Mohan Kumar, and P. Sravanthi. "Design, Formulation and In-Vitro Evaluation of Ketoconazole Microsponges by Quasi-Emulsion Solvent Diffusion Method." Journal of Drug Delivery and Therapeutics 15, no. 7 (2025): 19–24. https://doi.org/10.22270/jddt.v15i7.7244.

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Ketoconazole-loaded micro sponges were successfully formulated employing the quasi-emulsion solvent diffusion technique, aiming to optimize drug entrapment efficiency and enhance sustain release of the drug. Ethyl cellulose served as the release-retarding polymer, while polyvinyl alcohol (PVA) functioned as the emulsifying agent. Formulations were prepared in varying ratios of drug: PVA: ethyl cellulose to assess the impact of composition on micro sponge properties. The effect of variables including the drug: polymer ratio, emulsifier (PVA) concentration in organic solvent (dichloro methane) w

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10

V., Lakshmi Durga* G. Pavani Priya V. Sai Kishore M. V. Sai Krishna. "PREPARATION AND CHARACTERIZATION OF SPHERICAL AGGLOMERATED CRYSTALS LOADED FAST DISSOLVING TABLETS FOR ENHANCING THE SOLUBILITY OF IBUPROFEN." indo American Journal of Pharmaceutical Sciences 04, no. 05 (2017): 1414–21. https://doi.org/10.5281/zenodo.807176.

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The objective of the present work was to study the effect of different polymers on the solubility and dissolution rate of ibuprofen a poorly water soluble NSAIDs, by spherically agglomeration using methanol, water and dichloromethane as good solvent, poor solvent and bridging liquid, respectively. The quasi-emulsion solvent diffusion technique was used as a method for spherical agglomeration. Spherical agglomeration of ibuprofen were prepared by using polyethylene glycol-4000, polyethylene glycol-6000 and PVP k-30 as water soluble carries proportions like 1:0.5,1:0.75,1:1. The agglomerates wer

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11

Singh, Renuka, Sukhcharn Singh, and D. C. Saxena. "Quasi Emulsion Solvent Diffusion Modification of Underutilized Chenopodium album Starch and its Characterization." Asian Journal of Chemistry 34, no. 2 (2022): 355–60. http://dx.doi.org/10.14233/ajchem.2022.23513.

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The present study was designed to investigate the changes occur on Chenopodium album starch (CAS) after modification through quasi emulsion solvent diffusion (QESD) method. Modification of starch was carried out by HCl (0.1, 0.25, 0.50, 0.75 and 1M) followed by precipitation. The QESD modification significantly reduced the amylose content, water absorption capacity, oil absorption capacity, solubility as well as swelling power of treated starch. Gelatinization behaviour of modified starch showed an increase in pasting temperature. The SEM images showed the formation of regular and spherical sh

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12

Nocent, M., L. Bertocchi, F. Espitalier, M. Baron, and G. Couarraze. "Definition of a Solvent System for Spherical Crystallization of Salbutamol Sulfate by Quasi‐Emulsion Solvent Diffusion (QESD) Method." Journal of Pharmaceutical Sciences 90, no. 10 (2001): 1620–27. http://dx.doi.org/10.1002/jps.1112.

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13

Ré, M. I., and B. Biscans. "Preparation of microspheres of ketoprofen with acrylic polymers by a quasi-emulsion solvent diffusion method." Powder Technology 101, no. 2 (1999): 120–33. http://dx.doi.org/10.1016/s0032-5910(98)00163-6.

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14

Hans, Mansi, Jagdeep Singh Dua, D. N. Prasad, ,. Monika, and Diksha Sharma. "Formulation and Evaluation of Fluconazole Microsponge using Eudragit L 100 by Quasi Emulsion Solvent Diffusion Method." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 366–73. http://dx.doi.org/10.22270/jddt.v9i3-s.2855.

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The aim of the present study is to formulate and evaluate the fluconazole microsponge by using Eudragit L 100. Microsponge was made because they provide controlled as well as target specific release of the drug. Thus study the effect of stirring rate on the formation of microsponge. Microsponge containing Fluconazole were prepared by quasi-emulsion solvent diffusion method at different stirring rate i.e 500, 800, 1000, 1200 and 1500 rpm. Particle size of prepared microsponge was observed in the range of 76.2 to 32.5μm. Scanning electron microscopy revealed the porous, spherical nature of the m

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15

Jaswal, Saloni. "Detail work on formulation development and evaluation of micro sponges gel of clotrimazole for treatment of vaginal fungal infection." Indian Journal of Pharmacy and Pharmacology 10, no. 3 (2023): 204–14. http://dx.doi.org/10.18231/j.ijpp.2023.038.

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Vaginal infection is so widespread that women have to seek medical counseling. In fact, almost 70% of women experience vaginal infections in their life. Vulvovaginal candidiasis is responsible for vaginal infections and Candida albicans is the major agent. Vaginal infections are caused by hormonal changes, negative sexual effects, irrelevant quality of life, high mortality rate, depressive mood and various kind of anxiety.Detail Work on Formulation Development and Evaluation of Micro sponges gel of Clotrimazole for Treatment of Vaginal fungal Infection. The microsponge-based novel delivery sys

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16

Bansode, Ashwini S., Vaishnavi B. Kute, Komal S. Vethekar, et al. "Formulation, development and evaluation of Microsponge loaded Topical Gel of Nystatin." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 451–61. http://dx.doi.org/10.22270/jddt.v9i2-s.2567.

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Nystatin containing microsponge as active constituent (API) in different formulations by changing the proportions of drug (Nystatin), polymer (ethyl cellulose), emulsifier (Poly vinyl alcohol) were obtained successfully using quasi-emulsion solvent diffusion method. These formulations were studied for particle size and physical characterization. Scanning electron microscopy (SEM) images showed the microsponges porous and spherical in shape. The physical characterization showed that microsponge formulation coded by P6 showed a better loading efficiency and production yield. This microsponge for

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17

B, Hema Latha, Manisha E, Harshavardhini G, and Hyma P. "SPHERICAL CRYSTALLIZATION: A TOOL TO IMPROVE SOLUBILITY OF DRUGS." Journal of Advanced Scientific Research 13, no. 11 (2022): 28–34. http://dx.doi.org/10.55218/jasr.2022131105.

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Spherical crystallization is a technique in which crystallization and agglomeration are carried out synchronously in one step to form compact spherical form. The most common methods used in spherical agglomeration are quasi emulsion solvent diffusion method, ammonia diffusion system, neutralization technique and co-agglomeration. It succeeded to improve dissolution property of poorly soluble drugs. This can change drug powder properties such as flowability, wettability, packability, compressibility. It has wider applications in improvement of poorly compressible drugs; it has wider application

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18

Cui, Fude, Mingshi Yang, Yanyan Jiang, et al. "Design of sustained-release nitrendipine microspheres having solid dispersion structure by quasi-emulsion solvent diffusion method." Journal of Controlled Release 91, no. 3 (2003): 375–84. http://dx.doi.org/10.1016/s0168-3659(03)00275-x.

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19

Monika, ,., Jagdeep Singh Dua, D. N. Prasad, Mansi Hans, and Satish Kumari. "Preparation and Characterization of Itraconazole Microsponges using Eudragit RSPO and Study the Effect of Stirring on the Formation of Microsponges." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 451–58. http://dx.doi.org/10.22270/jddt.v9i3-s.2879.

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The purpose of the present study was to prepare and evaluate Itraconazole loaded microsponges using Eudragit for the controlled release of the drug and study the effect of stirring rate on the formation of microsponges. Microsponges containing Itraconazole were prepared by using quasi-emulsion solvent diffusion method at different stirring rate i.e. 500, 800, 1000, 1200 and 1500rpm. Particle size of prepared microsponge was observed in the range of 78.43 to 23.18 µm. Scanning electron microscopy revealed the porous, spherical nature of the microsponges. The production yield, entrapment efficie

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20

Jyoti, Patil* Shamal kadam Pallavi Gaikwad. "Spherical Crystallisation." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 9–14. https://doi.org/10.5281/zenodo.14021375.

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The flow and compressibility characteristics of microcrystalline drug candidates can be improved by using the spherical crystallization technique. Agglomerating solvents, quasi-emulsion solvent diffusion, and ammonia diffusion techniques are employed to achieve spherical crystallization of microcrystals. The direct tableting technique is becoming more important in pharmaceutical manufacturing because it saves money and time. A technique used in particle engineering called spherical agglomeration involves transforming fine crystals into a spherical shape. This improves the powder's size, shape,

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21

Yang, M. "Preparation of sustained-release nitrendipine microspheres with Eudragit RS and Aerosil using quasi-emulsion solvent diffusion method." International Journal of Pharmaceutics 259, no. 1-2 (2003): 103–13. http://dx.doi.org/10.1016/s0378-5173(03)00209-6.

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22

Bhausaheb, Vidhate Samiksha, and Pagire D.M. "Review on Microspheres: A Novel Approach in Drug Delivery System." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 07, no. 12 (2023): 1–11. http://dx.doi.org/10.55041/ijsrem27475.

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A well-designed controlled drug delivery system has the potential to address the limitations of conventional drug therapy and enhance the therapeutic effectiveness of a drug. Microspheres, which are characterized by their particle size being 1-1000 μm, are considered a novel and controlled drug delivery system. The spherical shape of microspheres contributes to their advantageous properties. This review focuses on the utilization of microspheres as a novel drug delivery system. These characteristics can be modified by altering the materials, methods, polymers, or techniques used in the product

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23

Yadav, Vishal, Prakash Jadhav, Shailaja Dombe, Anjali Bodhe, and Pranali Salunkhe. "FORMULATION AND EVALUATION OF MICROSPONGE GEL FOR TOPICAL DELIVERY OF ANTIFUNGAL DRUG." International Journal of Applied Pharmaceutics 9, no. 4 (2017): 30. http://dx.doi.org/10.22159/ijap.2017v9i4.17760.

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Objective: The purpose of present study aims to design novel drug delivery system containing oxiconazole nitrate microsponges and to prepare microsponge gel. Oxiconazole nitrate is an antifungal drug used in the treatment of fungal infection having a poor aqueous solubility, side effects and adverse reactions. The microsponge delivery system is unique technology for controlled release of active agents. Methods: The microsponges were prepared by quasi-emulsion solvent diffusion method by using polymer eudragit S-100 and eudragit L-100. All the formulated microsponges were subjected for various

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24

Kawashima, Y., T. Niwa, T. Handa, H. Takeuchi, T. Iwamoto, and K. Itoh. "Preparation of Controlled-Release Microspheres of Ibuprofen With Acrylic Polymers by a Novel Quasi-Emulsion Solvent Diffusion Method." Journal of Pharmaceutical Sciences 78, no. 1 (1989): 68–72. http://dx.doi.org/10.1002/jps.2600780118.

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25

Adheena Jeby, Adheena Jeby, Ganesh N. S. Ganesh N S, Adlin Jino Nesalin Adlin Jino Nesalin, and Vineeth Chandy. "Unlocking the potential of microsponges: A versatile andfuturistic approach to oral drug delivery." International Journal of Pharmaceutical Research and Applications 10, no. 1 (2025): 1059–68. https://doi.org/10.35629/4494-100110591068.

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Oral administration is widely regarded as the most practical and commonly used method for delivering medications. However, drugs with short half-lives and rapid gastrointestinal absorption are swiftly cleared from the bloodstream, necessitating frequent dosing. To address these challenges, oral controlled-release formulations have been developed. Among the innovative approaches in drug delivery systems, the Microsponge Delivery System (MDS) has gained significant attention.MDS consists of highly cross-linked, porous polymeric microspheres capable of entrapping a wide range of active compounds.

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26

Anjali, Bhansali Dr. A. Chandewar Dr. Madhuri Channawar Ashwini warnkar Anisha kohale. "Design And Chacterization of Novel Topical Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2915–25. https://doi.org/10.5281/zenodo.15450341.

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The present study focuses on the design and characterization of a novel topical drug delivery system incorporating Vitex negundo extract through microsponge technology followed by gel formulation. Vitex negundo, known for its potent anti-inflammatory and antimicrobial properties, and microsponges via the quasi-emulsion solvent diffusion technique, employing ethyl cellulose as the polymer and polyvinyl alcohol as the stabilizer. The prepared microsponges were characterized for particle size, surface morphology, entrapment efficiency, and thermal stability using techniques such as, scanning elec

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27

Jicky, T. Panicker Sojan Abraham Joshua Bineesha K. B. Julie E. James Shaiju S. Dharan. "Formulation And In Vitro Evaluation Of Gastroretentive Ranitidine Floating Microsponges." British Journal of BioMedical Research 03, no. 04 (2019): 965–82. https://doi.org/10.24942/bjbmr.2019.532.

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Ranitidine hydrochloride (BCS class III) is mainly used for the treatment of gastric ulcer and esophagititis, but its low bioavailability leads to shorter half-life. The aim of this research work is to formulate ranitidine floating micro sponges to improve the gastric residence time and sustained release action. Ranitidine floating micro sponges were prepared by quasi emulsion solvent diffusion method using the polymers ethyl cellulose, eudragit S and eudragit RS and their combination to produce six formulations (F1 – F6). FTIR reports confirmed the absence of incompatibilities between t

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28

Yang, M., F. Cui, Y. Fan, et al. "Effect of three types of additives in poor solvent on preparation of sustained-release nitrendipine microspheres by the quasi-emulsion solvent diffusion method." Journal of Drug Delivery Science and Technology 15, no. 2 (2005): 129–35. http://dx.doi.org/10.1016/s1773-2247(05)50017-0.

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29

Vidya K P, E. Gopinath, Ganesh N. S, J Adlin Jino Nesalin, and Vineeth Chandy. "Unveiling the potential of microsponges: Enhancing oral bioavailability." World Journal of Biology Pharmacy and Health Sciences 17, no. 2 (2024): 405–14. http://dx.doi.org/10.30574/wjbphs.2024.17.2.0085.

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Oral medication administration is widely recognized as the most practical and widely used method. Medications with a short half-life and easy absorption in the gastrointestinal tract are quickly removed by the bloodstream. To avoid these issues, oral controlled-release formulations have been created. There are a ton of novel formulation approaches in the realm of medication delivery systems. One new novel approach that is becoming increasingly well-liked these days is the usage of microsponges. A wide variety of active chemicals can be entrapped by the highly cross-linked, porous, polymeric st

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Vidya, K. P., Gopinath E., N. S. Ganesh, Adlin Jino Nesalin J, and Chandy Vineeth. "Unveiling the potential of microsponges: Enhancing oral bioavailability." World Journal of Biology Pharmacy and Health Sciences 17, no. 2 (2024): 405–14. https://doi.org/10.5281/zenodo.11297472.

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Oral medication administration is widely recognized as the most practical and widely used method. Medications with a short half-life and easy absorption in the gastrointestinal tract are quickly removed by the bloodstream. To avoid these issues, oral controlled-release formulations have been created. There are a ton of novel formulation approaches in the realm of medication delivery systems. One new novel approach that is becoming increasingly well-liked these days is the usage of microsponges. A wide variety of active chemicals can be entrapped by the highly cross-linked, porous, polymeric st

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31

Anju, Tomar* Dr. Narendra Mandoria Kamlesh Dashora Aashish Singh. "Microsponge: A Stable Microscopic Polymeric Delivery System." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 210–23. https://doi.org/10.5281/zenodo.14800431.

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Microsponge is polymeric delivery system and a drug carrier which have tiny microscopic structure with a larger porous surface. These are micro-sized particle with average diameter of 5-30 micron. The pores of a microsponge are used for entrapment of drug.  These are newer technologies which have been used to control the release of medicament from formulation and also it precises the drug in targeted delivery. Microsponges have several advantages like improved stability, extended release, improved bioavailability and précised drug targeting makes it a better carrier for drug than t

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Saboo, Shweta, and Yogesh Bhise. "Microsponge: An Innovative and Novel Strategy for Drug Delivery System." Der Pharma Chemica 16, no. 1 (2024): 13. https://doi.org/10.4172/0975-413X.16.1.211-223.

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The microsponge approach has become a highly competitive and rapidly evolving technology. They are porous, highly cross-linked, polymeric microspheres that can be efficiently incorporated into topical drug delivery systems for the purpose of release and retention of dosage form on the skin over a long period of time. Furthermore, they may modify drug release, enhance stability, improve patient compliance and reduce side effects. microsponge systems are non-toxic, non-irritating, non-mutagenic and non-allergenic. In general, there are multiple methods used to manufacture microsponges, such as t

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Shukla, Mukesh Kumar, and Abadhesh Kumar Niranjan. "Floating Microsponge: An Emerging Drug Delivery System." Journal of Drug Delivery and Therapeutics 12, no. 4-S (2022): 264–69. http://dx.doi.org/10.22270/jddt.v12i4-s.5553.

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Floating microsponges are a method to extend gastric residence time, there with the aid of using concentrated on site-responsive medicament liberate withinside the top GIT for locally or systemic effect. Gastro retentive dosage forms (GRDFs) are getting utilized from a totally long term to enhance treatment with numerous main medications. Floating microsponge significantly enhances the therapy of stomach with the aid of using liberating the medication locally and for that reason used for medication selecting at specific organ. This may be sustained over an extended period of time. Floating dru

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Neha, Sodiyal* Mayank Yadav Ranjit Shah. "Formulation And Evaluation Of Clotrimazole And Ketoconazole Combination Loaded Microsponge Gel Using Different Polymers For Topical Drug Delivery." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 1420–26. https://doi.org/10.5281/zenodo.13854311.

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A microsponge delivery system (MDS) is highly crosslinked, porous, polymeric, microsphere, polymeric system made up of porous microspheres that can store a variety of active substance and then release them gradually and in reaction to a trigger on the skin.  Microsponge has ability to retain in skin cell and prevent the dose dumping in blood circulation, which may cause side effects. Ketoconazole and clotrimazole have broad spectrum antifungal which shows fungi active static activity.  Ketoconazole loaded microsponge will be prepare by the quasi-emulsion solvent diffusion method usin

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35

Borawake, Payal D., Arumugam Kauslya, Jitendra V. Shinde, and Rajashree S. Chavan. "Microsponge as an Emerging Technique in Novel Drug Delivery System." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 171–82. http://dx.doi.org/10.22270/jddt.v11i1.4492.

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Numbers of developments are implemented in drug delivery system to achieve the goals of optimized efficacy, cost effectiveness of therapy. One of the latest, novel and highly evolving technologies is microsponge drug delivery system which gives controlled release and site specific delivery of active ingredients. They are highly cross linked, porous and polymeric microspheres with size range of 5-300µm. This system is emerging as valuable option for topical delivery of drugs due to characteristics like decreased side effects, improved stability, better formulation flexibility, superior product

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36

Bhagat, N. B., A. V. Yadav, P. R. Mastud, and R. A. Khutale. "An Overview of Optimization of Spherical Crystallisation Process." International Journal of Pharmaceutical Sciences and Nanotechnology 6, no. 4 (2013): 2203–9. http://dx.doi.org/10.37285/ijpsn.2013.6.4.2.

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In this article we describe the optimizing parameters in the process of spherical crystallisation. Particle engineering of active pharmaceutical agents is an innovative area of research in pharmaceutical industry because of several advantages. Spherical crystallization is one of the particle engineering technique in which drug directly gets crystallized and agglomerated into spherical shape. The spherical crystals can be obtained by different methods like solvent change, Quasi-emulsion droplet, ammonia diffusion and neutralisation. The optimization of process of spherical crystallization is im

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Patel, S. S., M. R. Patel, and M. J. Patel. "Formulation and Evaluation of Microsponge Based Nicorandil Sustained Released Tablet." Journal of Scientific Research 9, no. 3 (2017): 285–96. http://dx.doi.org/10.3329/jsr.v9i3.31193.

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The aim of the present work was to develop once-daily sustained release microsponges formulations of Nicorandil, a potent potassium channel opener used in cardiovascular diseases and it has low oral bioavailability (70%) and half-life 1 h. So, it is good candidate for sustained release formulations based on microsponge technology. The microsponges were prepared by using quasi-emulsion solvent diffusion method. Scanning Electron Microscopy (SEM) revealed that the microsponges of nicorandil with Eudragit - RSPO and HPMC K100M were smooth, porous, glossy and discrete spherical. The actual drug co

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Puglia, Carmelo, Debora Santonocito, Teresa Musumeci, et al. "Nanotechnological Approach to Increase the Antioxidant and Cytotoxic Efficacy of Crocin and Crocetin." Planta Medica 85, no. 03 (2018): 258–65. http://dx.doi.org/10.1055/a-0732-5757.

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AbstractCrocin and crocetin are two interesting constituents of saffron (Crocus sativus) that possess important biological activities. Their use as therapeutic agents is strongly compromised by a scarce stability, poor absorption, and low bioavailability. Therefore, to improve these unfavorable features, the aim of the present work has been to apply a nanotechnological approach based on the formulation of solid lipid nanoparticles containing crocin and crocetin. Solid lipid nanoparticles were formulated according to crocin and crocetin chemical properties, using a variation of the quasi-emulsi

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V.PavanKumar*, and V.Saikishore. "DESIGN AND DEVELOPMENT OF SPHERICAL AGGLOMERATED CRYSTALS LOADED FAST DISSOLVING TABLETS FOR ENHANCING THE SOLUBILITY OF IBUPROFEN." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 08 (2018): 8230–36. https://doi.org/10.5281/zenodo.1407516.

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The main focus of this work was to enhance the solubility and bioavailability of Ibuprofen by using spherical crystallization technique. This technique was developed by Kawashima and their coworkers in 1986, by which crystallization and agglomeration can be carried out at once in a single step to convert crystals straight into compressed spherical form. Spherical agglomerates were obtained by the quasi-emulsion solvent diffusion method, in which ibuprofen was dissolved in the mixture of methanol (good solvent), dichloromethane (bridging liquid) and poor solvent (distilled water containing poly

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SANO, Akimitsu, Takeo KURIKI, Yoshiaki KAWASHIMA, Hirofumi TAKEUCHI, Tomoaki HINO, and Toshiyuki NIWA. "Particle design of tolbutamide by the spherical crystallization technique. III. Micromeritic properties and dissolution rate of tolbutamide spherical agglomerates prepared by the quasi-emulsion solvent diffusion method and the solvent change method." CHEMICAL & PHARMACEUTICAL BULLETIN 38, no. 3 (1990): 733–39. http://dx.doi.org/10.1248/cpb.38.733.

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Zakeri-Milani, Parvin, Ziba Islambulchilar, Fatemeh Majidpour, Ensieh Jannatabadi, Farzaneh Lotfipour, and Hadi Valizadeh. "A study on enhanced intestinal permeability of clarithromycin nanoparticles." Brazilian Journal of Pharmaceutical Sciences 50, no. 1 (2014): 121–29. http://dx.doi.org/10.1590/s1984-82502011000100012.

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The main objective of the present study was to determine the permeability of clarithromycin (CLA)-PLGA nanoparticles using single-pass intestinal perfusion technique in rats. Clarithromycin nanoparticles were prepared by nano-precipitation according to the modified quasi emulsion solvent diffusion technique and evaluated for their physicochemical characteristics. Permeability coefficients (Peff) in anaesthetized rats were determined at 3 different concentrations. Drug solution or suspensions in PBS was perfused through a cannulated jejunal segment and samples were taken from outlet tubing at d

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MUJAHID KHAN, Vicky kumar, Vivek Tiwari, Yadav Rahul Rajnath, and Faizan Altaf. "Design development and evaluation of controlled release micro-sponge drug delivery system." GSC Biological and Pharmaceutical Sciences 31, no. 2 (2025): 071–84. https://doi.org/10.30574/gscbps.2025.31.2.0178.

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The present study focuses on the design, development, and evaluation of a controlled release micro-sponge drug delivery system for Nimesulide, aimed at enhancing therapeutic efficacy and reducing dosing frequency. Micro-sponges were prepared using the quasi-emulsion solvent diffusion method, a simple and reproducible technique that enables the formation of porous polymeric microspheres. Ethyl cellulose was employed as the polymer matrix due to its biocompatibility and sustained release properties. Pre-formulation studies confirmed the physicochemical suitability of Nimesulide for micro-sponge

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Mithlesh, pal, and pratap singh Tej. "Formulation and evaluation of Budesonide loaded Microsponges for colon drug delivery." International Journal for Research Trends and Innovation 7, no. 9 (2022): 742–68. https://doi.org/10.5281/zenodo.11351972.

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Drug targeting to specific sites creates a challenging task for the formulation designer. These problems may be solved by the formulating the vesicular carrier system with in micro size range. Microsponges is microtechnology based formulation which offers controlled release of drug at the target site. Budesonide is a glucocorticoid steroid used for the treatment of several colonic diseases like chron’s disease, ulcerative disease and colon cancer. The low water solubility and poor bioavailability of budesonide is the challenging problem facing by the formulation scientist. It can be over

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K.Ashok, *. and M.V. Nagabhushanam. "DESIGN AND EVALUATION OF SPHERICAL AGGLOMERATED CRYSTALS LOADED FAST DISOLVING TABLETS FOR ENHANCING THE SOLUBILITYOF MEFENAMIC ACID." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 4610–16. https://doi.org/10.5281/zenodo.1069481.

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The objective of the present work was to study the effect of different polymers on the solubility and dissolution rate of Mefenamic acid a poorly water soluble NSAIDs, by spherically agglomeration using methanol, water and dichloromethane as good solvent, poor solvent and bridging liquid, respectively. The quasi-emulsion solvent diffusion technique was used as a method for spherical agglomeration. Spherical agglomeration of Mefenamic acid were prepared by using Poloxomer -F338 and Gelucire 48/16 in the ratio of 1:0.5,1:0.75,1:1. The agglomerates were subjected to various physicochemical evalua

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M.Suresh, babu *. and T. E. Gopala Krishna murthy. "DESIGN AND CHARACTERIZATION OF SPHERICAL AGGLOMERATED CRYSTALS LOADED FAST DISOLVING TABLETS FOR ENHANCING THE SOLUBILITY OF SIMVASTATIN." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 04, no. 12 (2017): 5002–8. https://doi.org/10.5281/zenodo.1408036.

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In the present work an attempt was done to study the effect of different carriers on the solubility and dissolution rate of Simvastatin poorly water soluble drug, by spherically agglomeration using N,N-dimethylformamide, water and chloroform as good solvent, poor solvent and bridging liquid, respectively. The quasi-emulsion solvent diffusion technique was used as a method for spherical agglomeration. Spherical agglomeration of Simvastatin were prepared by using Poloxomer -F338 and Gelucire 48/16 in the ratio of 1:0.5,1:0.75,1:1. The agglomerates were subjected to various physicochemical evalua

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Tyagi Gajendra, Choudhary Suresh, and Kalra Naresh. "Formulation of microsponges of anti-fungal drugs and their pharmacokinetic and in vitro analysis." Tropical Journal of Pharmaceutical and Life Sciences 11, no. 2 (2024): 24–44. http://dx.doi.org/10.61280/tjpls.v11i2.158.

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Microsponges are uniform, spherical, porous polymeric microspheres having myriad interconnected voids of particle size range 5-300 μm. These microsponges have the capacity to entrap a wide range of active ingredients such as emollients, fragrances, essential oils, sunscreens and anti-infective, etc. and then release them onto the skin over a time in response to a trigger. Microsponge Delivery System (MDS) can be used to resolve the problem associated with these conventional approaches. The drug entrapped microsponges can be incorporated into a formulated product, such as a gel, cream, liquid o

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Vishwakarma, Rinki, and Harshal Tare. "Evaluation of Insulin Loaded Microspheres for Oral Delivery." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 04 (2023): 1489–96. http://dx.doi.org/10.25258/ijddt.13.4.56.

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Microsphere-based colon-specific medication delivery devices should improve bioactive chemical administration and residence periods. In the first step, insulin microspheres were made using Eudragit RL 100 and L-100 by quasi-emulsion solvent diffusion. Microspheres were made since prior research showed that colon tissue macrophages could take up drug carrier systems with a molecular weight of 956 m or less. The uptake process allows accurate medication delivery to the specified site. Microspheres’ longer residence time than conventional drug delivery methods may allow dosage reduction and thera

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Kranti, Kumar Bajpai, B. Puranik Sangamesh, Saraswat Rohit, Sharma Ritu, and Sharma Prashant. "Design Development and Evaluation of Acyclovir Loaded Compressed Microsponge." International Journal of Engineering Research & Science 6, no. 9 (2020): 24–37. https://doi.org/10.5281/zenodo.4090921.

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<strong>Abstract</strong><strong>—</strong> The Microsponge Drug Delivery System (MDS) is a patented technology has been successively used for the controlled release of topical agents which consist of macro porous beads, typically 10-25 microns in a diameter, which are loaded with active agent. Allowing a sustained flow of substances out of the sphere, the outer surface is typically porous, This system can suspend or entrap a wide variety of substances, and incorporated into a formulated product such as a liquid, gel, cream, or powder. The Microsponge shows time mode release when applied

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Sareen, Rashmi, Kavita Nath, Nitin Jain, and K. L. Dhar. "Curcumin Loaded Microsponges for Colon Targeting in Inflammatory Bowel Disease: Fabrication, Optimization, andIn Vitroand Pharmacodynamic Evaluation." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/340701.

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The present study was aimed to develop and optimize the microsponges of curcumin for colon specific drug delivery in a view to bypass the upper gastrointestinal tract (GIT) for enhanced therapeutic effect. Microsponges were developed by quasi emulsion solvent diffusion method using 32full factorial design. Prepared microsponges were optimized in order to analyze the effects of independent variables (volume of ethanol and Eudragit L100) on the encapsulation efficiency, particle size, and drug release. The optimized formulation was subjected toin vivostudy using acetic acid induced colitis model

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Kamble, Srushti, Gangotri Yadav, and Ashish Jain. "Formulation and Evaluation of Terbinafine Hydro-chloride Loaded Microsponges Gel." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 16, no. 6 (2023): 7038–48. http://dx.doi.org/10.37285/ijpsn.2023.16.6.3.

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Background: Microsponges are porous, polymeric microspheres employed for sustained topical treatment. They may modify the release pattern, lessen adverse effects, and improve stability. Terbinafine HCL is a fungicidal allylamine derivative with a wide range of antifungal activity. It is used to treat various skin disorders like ringworm, athlete’s foot, and jock itch. Objective: The aim of the current study focuses on the development of terbinafine HCL microsponges that will release the drug in a sustained pattern to prevent side effects and then put those microsponges into a gel. Method: The

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